| 14 Aug 21 | r01        | Fortuna Düsseldorf IIFortuna Düsse | 2 - 1 | Sportfreunde LotteSportfreunde |
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| 21 Aug 21 | r02        | Wegberg-BeeckWegberg-Beeck | 1 - 2 | Fortuna Düsseldorf IIFortuna Düsse |
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| 25 Aug 21 | r03        | Fortuna Düsseldorf IIFortuna Düsse | 3 - 1 | RödinghausenRödinghausen |
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| 28 Aug 21 | r04        | Rot Weiss AhlenRot Weiss Ahl | 1 - 1 | Fortuna Düsseldorf IIFortuna Düsse |
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| 11 Sep 21 | r06        | StraelenStraelen | 1 - 1 | Fortuna Düsseldorf IIFortuna Düsse |
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| 15 Sep 21 | r07        | Fortuna Düsseldorf IIFortuna Düsse | 1 - 2 | Wuppertaler SVWuppertaler S |
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| 19 Sep 21 | r08        | Fortuna KölnFortuna Köln | 0 - 0 | Fortuna Düsseldorf IIFortuna Düsse |
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| 25 Sep 21 | r09        | Bonner SCBonner SC | 0 - 3 | Fortuna Düsseldorf IIFortuna Düsse |
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| 02 Oct 21 | r10        | Fortuna Düsseldorf IIFortuna Düsse | 4 - 0 | VfB HombergVfB Homberg |
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| 09 Oct 21 | r11        | Preußen MünsterPreußen Münst | 2 - 0 | Fortuna Düsseldorf IIFortuna Düsse |
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| 15 Oct 21 | r12        | Fortuna Düsseldorf IIFortuna Düsse | 5 - 1 | Schalke 04 IISchalke 04 II |
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| 23 Oct 21 | r13        | Lippstadt 08Lippstadt 08 | 5 - 2 | Fortuna Düsseldorf IIFortuna Düsse |
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| 27 Oct 21 | r05        | Fortuna Düsseldorf IIFortuna Düsse | 3 - 3 | Rot-Weiss EssenRot-Weiss Ess |
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| 31 Oct 21 | r14        | Fortuna Düsseldorf IIFortuna Düsse | 2 - 2 | Rot-Weiß OberhausenRot-Weiß Ober |
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| 06 Nov 21 | r15        | KFC Uerdingen 05KFC Uerdingen | 1 - 1 | Fortuna Düsseldorf IIFortuna Düsse |
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| 21 Nov 21 | r17        | FC Koln IIFC Koln II | 1 - 1 | Fortuna Düsseldorf IIFortuna Düsse |
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| 26 Nov 21 | r18        | Fortuna Düsseldorf IIFortuna Düsse | 3 - 0 | AachenAachen |
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| 08 Dec 21 | r16        | Fortuna Düsseldorf IIFortuna Düsse | 2 - 4 | WiedenbrückWiedenbrück |
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| 14 Dec 21 | r20        | Sportfreunde LotteSportfreunde | 3 - 1 | Fortuna Düsseldorf IIFortuna Düsse |
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| 18 Dec 21 | r21        | Fortuna Düsseldorf IIFortuna Düsse | 1 - 3 | Wegberg-BeeckWegberg-Beeck |
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| 02 Feb 22 | r19        | Mgladbach IIMgladbach II | 0 - 3 | Fortuna Düsseldorf IIFortuna Düsse |
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| 06 Feb 22 | r24        | Rot-Weiss EssenRot-Weiss Ess | 4 - 1 | Fortuna Düsseldorf IIFortuna Düsse |
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| 12 Feb 22 | r25        | Fortuna Düsseldorf IIFortuna Düsse | 0 - 4 | StraelenStraelen |
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| 15 Feb 22 | r23        | Fortuna Düsseldorf IIFortuna Düsse | 1 - 1 | Rot Weiss AhlenRot Weiss Ahl |
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| 27 Feb 22 | r27        | Fortuna Düsseldorf IIFortuna Düsse | 1 - 1 | Fortuna KölnFortuna Köln |
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| 05 Mar 22 | r28        | Fortuna Düsseldorf IIFortuna Düsse | 1 - 2 | Bonner SCBonner SC |
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| 12 Mar 22 | r29        | VfB HombergVfB Homberg | 0 - 2 | Fortuna Düsseldorf IIFortuna Düsse |
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| 16 Mar 22 | r22        | RödinghausenRödinghausen | 4 - 1 | Fortuna Düsseldorf IIFortuna Düsse |
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| 20 Mar 22 | r30        | Fortuna Düsseldorf IIFortuna Düsse | 0 - 1 | Preußen MünsterPreußen Münst |
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| 25 Mar 22 | r31        | Schalke 04 IISchalke 04 II | 0 - 4 | Fortuna Düsseldorf IIFortuna Düsse |
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| 02 Apr 22 | r32        | Fortuna Düsseldorf IIFortuna Düsse | 1 - 4 | Lippstadt 08Lippstadt 08 |
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| 08 Apr 22 | r33        | Rot-Weiß OberhausenRot-Weiß Ober | 2 - 1 | Fortuna Düsseldorf IIFortuna Düsse |
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| 13 Apr 22 | r26        | Wuppertaler SVWuppertaler S | 0 - 2 | Fortuna Düsseldorf IIFortuna Düsse |
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| 16 Apr 22 | r34        | Fortuna Düsseldorf IIFortuna Düsse | 1 - 0 | KFC Uerdingen 05KFC Uerdingen |
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| 23 Apr 22 | r35        | WiedenbrückWiedenbrück | 3 - 1 | Fortuna Düsseldorf IIFortuna Düsse |
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| 29 Apr 22 | r36        | Fortuna Düsseldorf IIFortuna Düsse | 0 - 1 | FC Koln IIFC Koln II |
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| 06 May 22 | r37        | AachenAachen | 3 - 1 | Fortuna Düsseldorf IIFortuna Düsse |
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| 14 May 22 | r38        | Fortuna Düsseldorf IIFortuna Düsse | 0 - 0 | Mgladbach IIMgladbach II |