| 26 Sep 21 | r01        | AFC LeopardsAFC Leopards | 1 - 0 | TuskerTusker |
| |
| 16 Oct 21 | r02        | KCBKCB | 0 - 0 | AFC LeopardsAFC Leopards |
| 20 Oct 21 | r02        | AFC LeopardsAFC Leopards | 0 - 1 | GOR MahiaGOR Mahia |
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| 24 Oct 21 | r04        | BandariBandari | 2 - 1 | AFC LeopardsAFC Leopards |
| |
| 29 Oct 21 | r05        | AFC LeopardsAFC Leopards | 0 - 2 | Ulinzi StarsUlinzi Stars |
| |
| 07 Nov 21 | r06        | SofapakaSofapaka | 1 - 0 | AFC LeopardsAFC Leopards |
| |
| 04 Dec 21 | r09        | Bidco UnitedBidco United | 1 - 0 | AFC LeopardsAFC Leopards |
| |
| 09 Dec 21 | r10        | AFC LeopardsAFC Leopards | 1 - 0 | Posta Rangers FCPosta Rangers |
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| 12 Dec 21 | r11        | Vihiga BulletsVihiga Bullet | 1 - 1 | AFC LeopardsAFC Leopards |
| |
| 19 Dec 21 | r12        | TalantaTalanta | 1 - 1 | AFC LeopardsAFC Leopards |
| 29 Dec 21 | r12        | AFC LeopardsAFC Leopards | 2 - 2 | HomeboyzHomeboyz |
| |
| 05 Jan 22 | r13        | Nairobi City StarsNairobi City | 0 - 1 | AFC LeopardsAFC Leopards |
| |
| 09 Jan 22 | r14        | AFC LeopardsAFC Leopards | 1 - 1 | Nzoia SugarNzoia Sugar |
| |
| 15 Jan 22 | r15        | Kariobangi SharksKariobangi Sh | 3 - 1 | AFC LeopardsAFC Leopards |
| |
| 20 Jan 22 | r08        | AFC LeopardsAFC Leopards | 3 - 1 | Mathare UnitedMathare Unite |
| |
| 23 Jan 22 | r15        | AFC LeopardsAFC Leopards | 1 - 2 | Mathare UnitedMathare Unite |
| |
| 06 Feb 22 | r19        | AFC LeopardsAFC Leopards | 1 - 1 | Bidco UnitedBidco United |
| |
| 13 Feb 22 | r23        | Posta Rangers FCPosta Rangers | 1 - 3 | AFC LeopardsAFC Leopards |
| |
| 27 Feb 22 | r19        | Vihiga BulletsVihiga Bullet | 0 - 0 | AFC LeopardsAFC Leopards |
| |
| 27 Feb 22 | r21        | AFC LeopardsAFC Leopards | 0 - 0 | Vihiga BulletsVihiga Bullet |
| |
| 06 Mar 22 | r15        | BandariBandari | 2 - 2 | AFC LeopardsAFC Leopards |
| |
| 06 Mar 22 | r19        | AFC LeopardsAFC Leopards | 2 - 2 | BandariBandari |
| |
| 09 Mar 22 | r16        | Ulinzi StarsUlinzi Stars | - | AFC LeopardsAFC Leopards |
| |
| 13 Mar 22 | r24        | AFC LeopardsAFC Leopards | 1 - 1 | SofapakaSofapaka |
| |
| 03 Apr 22 | r20        | Kenya PoliceKenya Police | 0 - 3 | AFC LeopardsAFC Leopards |
| |
| 10 Apr 22 | r08        | Wazito FCWazito FC | 1 - 2 | AFC LeopardsAFC Leopards |
| |
| 18 Apr 22 | r18        | AFC LeopardsAFC Leopards | 1 - 1 | Wazito FCWazito FC |
| |
| 24 Apr 22 | r25        | TuskerTusker | 2 - 1 | AFC LeopardsAFC Leopards |
| |
| 24 Apr 22 | r13        | AFC LeopardsAFC Leopards | 2 - 1 | TuskerTusker |
| |
| 01 May 22 | r16        | AFC LeopardsAFC Leopards | 2 - 1 | KCBKCB |
| |
| 08 May 22 | r17        | GOR MahiaGOR Mahia | 1 - 1 | AFC LeopardsAFC Leopards |
| 14 May 22 | r17        | AFC LeopardsAFC Leopards | - | Kariobangi SharksKariobangi Sh |
| |
| 21 May 22 | r22        | AFC LeopardsAFC Leopards | 3 - 2 | TalantaTalanta |
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| 29 May 22 | r14        | HomeboyzHomeboyz | 0 - 2 | AFC LeopardsAFC Leopards |
| |
| 06 Jun 22 | r22        | AFC LeopardsAFC Leopards | 1 - 1 | Nairobi City StarsNairobi City |
| 12 Jun 22 | r22        | Nzoia SugarNzoia Sugar | 3 - 1 | AFC LeopardsAFC Leopards |