| 26 Sep 21 | r01  | AFC LeopardsAFC Leopards | 1 - 0 | TuskerTusker |
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| 16 Oct 21 | r02 | KCBKCB | 0 - 0 | AFC LeopardsAFC Leopards |
| 20 Oct 21 | r02 | AFC LeopardsAFC Leopards | 0 - 1 | GOR MahiaGOR Mahia |
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| 24 Oct 21 | r04 | BandariBandari | 2 - 1 | AFC LeopardsAFC Leopards |
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| 29 Oct 21 | r05 | AFC LeopardsAFC Leopards | 0 - 2 | Ulinzi StarsUlinzi Stars |
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| 07 Nov 21 | r06 | SofapakaSofapaka | 1 - 0 | AFC LeopardsAFC Leopards |
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| 04 Dec 21 | r09 | Bidco UnitedBidco United | 1 - 0 | AFC LeopardsAFC Leopards |
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| 09 Dec 21 | r10 | AFC LeopardsAFC Leopards | 1 - 0 | Posta Rangers FCPosta Rangers |
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| 12 Dec 21 | r11 | Vihiga BulletsVihiga Bullet | 1 - 1 | AFC LeopardsAFC Leopards |
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| 19 Dec 21 | r12 | TalantaTalanta | 1 - 1 | AFC LeopardsAFC Leopards |
| 29 Dec 21 | r12 | AFC LeopardsAFC Leopards | 2 - 2 | HomeboyzHomeboyz |
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| 05 Jan 22 | r13 | Nairobi City StarsNairobi City | 0 - 1 | AFC LeopardsAFC Leopards |
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| 09 Jan 22 | r14 | AFC LeopardsAFC Leopards | 1 - 1 | Nzoia SugarNzoia Sugar |
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| 15 Jan 22 | r15 | Kariobangi SharksKariobangi Sh | 3 - 1 | AFC LeopardsAFC Leopards |
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| 20 Jan 22 | r08 | AFC LeopardsAFC Leopards | 3 - 1 | Mathare UnitedMathare Unite |
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| 23 Jan 22 | r15 | AFC LeopardsAFC Leopards | 1 - 2 | Mathare UnitedMathare Unite |
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| 06 Feb 22 | r19 | AFC LeopardsAFC Leopards | 1 - 1 | Bidco UnitedBidco United |
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| 13 Feb 22 | r23 | Posta Rangers FCPosta Rangers | 1 - 3 | AFC LeopardsAFC Leopards |
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| 27 Feb 22 | r19 | Vihiga BulletsVihiga Bullet | 0 - 0 | AFC LeopardsAFC Leopards |
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| 27 Feb 22 | r21 | AFC LeopardsAFC Leopards | 0 - 0 | Vihiga BulletsVihiga Bullet |
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| 06 Mar 22 | r15 | BandariBandari | 2 - 2 | AFC LeopardsAFC Leopards |
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| 06 Mar 22 | r19 | AFC LeopardsAFC Leopards | 2 - 2 | BandariBandari |
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| 09 Mar 22 | r16 | Ulinzi StarsUlinzi Stars | - | AFC LeopardsAFC Leopards |
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| 13 Mar 22 | r24 | AFC LeopardsAFC Leopards | 1 - 1 | SofapakaSofapaka |
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| 03 Apr 22 | r20 | Kenya PoliceKenya Police | 0 - 3 | AFC LeopardsAFC Leopards |
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| 10 Apr 22 | r08 | Wazito FCWazito FC | 1 - 2 | AFC LeopardsAFC Leopards |
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| 18 Apr 22 | r18 | AFC LeopardsAFC Leopards | 1 - 1 | Wazito FCWazito FC |
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| 24 Apr 22 | r25 | TuskerTusker | 2 - 1 | AFC LeopardsAFC Leopards |
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| 24 Apr 22 | r13 | AFC LeopardsAFC Leopards | 2 - 1 | TuskerTusker |
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| 01 May 22 | r16 | AFC LeopardsAFC Leopards | 2 - 1 | KCBKCB |
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| 08 May 22 | r17 | GOR MahiaGOR Mahia | 1 - 1 | AFC LeopardsAFC Leopards |
| 14 May 22 | r17 | AFC LeopardsAFC Leopards | - | Kariobangi SharksKariobangi Sh |
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| 21 May 22 | r22 | AFC LeopardsAFC Leopards | 3 - 2 | TalantaTalanta |
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| 29 May 22 | r14 | HomeboyzHomeboyz | 0 - 2 | AFC LeopardsAFC Leopards |
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| 06 Jun 22 | r22 | AFC LeopardsAFC Leopards | 1 - 1 | Nairobi City StarsNairobi City |
| 12 Jun 22 | r22 | Nzoia SugarNzoia Sugar | 3 - 1 | AFC LeopardsAFC Leopards |
Team 2021-2022 Schedules
AFC Leopards
APS Bomet
Bandari
Bidco United
Gor Mahia
Kakamega Homeboyz
Kariobangi Sharks
KCB
Kenya Police
Mara Sugar
Mathare United
Murang'a Seal
Nairobi United
Nzoia Sugar
Posta Rangers
Shabana
Sofapaka
Tusker
Ulinzi Stars
League Table
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