| 25 Sep 21 | r01        | BandariBandari | 3 - 0 | Mathare UnitedMathare Unite |
| |
| 16 Oct 21 | r02        | Mathare UnitedMathare Unite | 0 - 1 | Ulinzi StarsUlinzi Stars |
| |
| 20 Oct 21 | r03        | SofapakaSofapaka | 1 - 2 | Mathare UnitedMathare Unite |
| |
| 24 Oct 21 | r04        | Nzoia SugarNzoia Sugar | 1 - 2 | Mathare UnitedMathare Unite |
| |
| 31 Oct 21 | r05        | Mathare UnitedMathare Unite | 0 - 6 | Kariobangi SharksKariobangi Sh |
| 06 Nov 21 | r05        | Mathare UnitedMathare Unite | 0 - 1 | Bidco UnitedBidco United |
| |
| 04 Dec 21 | r10        | Mathare UnitedMathare Unite | 0 - 2 | TalantaTalanta |
| 08 Dec 21 | r10        | HomeboyzHomeboyz | 2 - 2 | Mathare UnitedMathare Unite |
| |
| 11 Dec 21 | r11        | Mathare UnitedMathare Unite | 0 - 2 | Nairobi City StarsNairobi City |
| |
| 19 Dec 21 | r12        | Wazito FCWazito FC | 4 - 1 | Mathare UnitedMathare Unite |
| |
| 30 Dec 21 | r18        | TuskerTusker | 4 - 1 | Mathare UnitedMathare Unite |
| |
| 04 Jan 22 | r13        | Mathare UnitedMathare Unite | 0 - 1 | KCBKCB |
| |
| 09 Jan 22 | r14        | GOR MahiaGOR Mahia | 1 - 0 | Mathare UnitedMathare Unite |
| |
| 20 Jan 22 | r08        | AFC LeopardsAFC Leopards | 3 - 1 | Mathare UnitedMathare Unite |
| |
| 23 Jan 22 | r15        | AFC LeopardsAFC Leopards | 1 - 2 | Mathare UnitedMathare Unite |
| |
| 05 Feb 22 | r16        | Mathare UnitedMathare Unite | 0 - 2 | TalantaTalanta |
| |
| 05 Feb 22 | r18        | TalantaTalanta | 0 - 2 | Mathare UnitedMathare Unite |
| |
| 12 Feb 22 | r19        | Mathare UnitedMathare Unite | 1 - 3 | HomeboyzHomeboyz |
| |
| 26 Feb 22 | r13        | Nairobi City StarsNairobi City | 3 - 0 | Mathare UnitedMathare Unite |
| |
| 05 Mar 22 | r18        | Nzoia SugarNzoia Sugar | 0 - 3 | Mathare UnitedMathare Unite |
| 05 Mar 22 | r18        | Mathare UnitedMathare Unite | 0 - 3 | Nzoia SugarNzoia Sugar |
| |
| 09 Mar 22 | r21        | Mathare UnitedMathare Unite | 1 - 1 | Kariobangi SharksKariobangi Sh |
| |
| 09 Mar 22 | r19        | Kariobangi SharksKariobangi Sh | 1 - 1 | Mathare UnitedMathare Unite |
| |
| 13 Mar 22 | r25        | Bidco UnitedBidco United | 2 - 0 | Mathare UnitedMathare Unite |
| |
| 17 Mar 22 | r14        | Mathare UnitedMathare Unite | 2 - 3 | Posta Rangers FCPosta Rangers |
| |
| 03 Apr 22 | r06        | Posta Rangers FCPosta Rangers | 2 - 1 | Mathare UnitedMathare Unite |
| |
| 09 Apr 22 | r08        | Mathare UnitedMathare Unite | 0 - 1 | Vihiga BulletsVihiga Bullet |
| |
| 16 Apr 22 | r24        | Mathare UnitedMathare Unite | 2 - 0 | Vihiga BulletsVihiga Bullet |
| |
| 24 Apr 22 | r15        | Mathare UnitedMathare Unite | - | BandariBandari |
| |
| 30 Apr 22 | r21        | Ulinzi StarsUlinzi Stars | 2 - 0 | Mathare UnitedMathare Unite |
| |
| 06 May 22 | r20        | SofapakaSofapaka | 0 - 2 | Mathare UnitedMathare Unite |
| |
| 21 May 22 | r23        | Wazito FCWazito FC | - | Mathare UnitedMathare Unite |
| |
| 28 May 22 | r24        | TuskerTusker | - | Mathare UnitedMathare Unite |
| |
| 05 Jun 22 | r16        | KCBKCB | - | Mathare UnitedMathare Unite |
| |
| 11 Jun 22 | r17        | Mathare UnitedMathare Unite | - | GOR MahiaGOR Mahia |