| 24 Jan 22 | r16        | Nairobi City StarsNairobi City | 1 - 1 | HomeboyzHomeboyz |
| 05 Feb 22 | r16        | Mathare UnitedMathare Unite | 0 - 2 | TalantaTalanta |
| 06 Feb 22 | r16        | Kenya PoliceKenya Police | 0 - 0 | SofapakaSofapaka |
| 06 Feb 22 | r16        | Posta Rangers FCPosta Rangers | 3 - 1 | GOR MahiaGOR Mahia |
| 12 Feb 22 | r16        | TalantaTalanta | 0 - 1 | Bidco UnitedBidco United |
| 09 Mar 22 | r16        | Ulinzi StarsUlinzi Stars | - | AFC LeopardsAFC Leopards |
| 09 Mar 22 | r16        | Bidco UnitedBidco United | 1 - 1 | Nzoia SugarNzoia Sugar |
| 03 Apr 22 | r16        | Nzoia SugarNzoia Sugar | 0 - 0 | Vihiga BulletsVihiga Bullet |
| 03 Apr 22 | r16        | Kariobangi SharksKariobangi Sh | 2 - 1 | Bidco UnitedBidco United |
| 23 Apr 22 | r16        | Posta Rangers FCPosta Rangers | 3 - 2 | Kariobangi SharksKariobangi Sh |
| 01 May 22 | r16        | AFC LeopardsAFC Leopards | 2 - 1 | KCBKCB |
| 15 May 22 | r16        | HomeboyzHomeboyz | 2 - 1 | KCBKCB |
| 21 May 22 | r16        | GOR MahiaGOR Mahia | 1 - 1 | HomeboyzHomeboyz |
| 22 May 22 | r16        | TuskerTusker | 2 - 2 | Nzoia SugarNzoia Sugar |
| 28 May 22 | r16        | BandariBandari | 0 - 0 | Ulinzi StarsUlinzi Stars |
| 04 Jun 22 | r16        | SofapakaSofapaka | 0 - 1 | BandariBandari |
| 05 Jun 22 | r16        | KCBKCB | - | Mathare UnitedMathare Unite |
| 05 Jun 22 | r16        | TalantaTalanta | 0 - 2 | HomeboyzHomeboyz |
| 12 Jun 22 | r16        | Wazito FCWazito FC | 2 - 0 | Vihiga BulletsVihiga Bullet |