| 15 Jan 22 | r15        | Kariobangi SharksKariobangi Sh | 3 - 1 | AFC LeopardsAFC Leopards |
| 16 Jan 22 | r15        | GOR MahiaGOR Mahia | 2 - 0 | TalantaTalanta |
| 16 Jan 22 | r15        | Vihiga BulletsVihiga Bullet | 1 - 1 | BandariBandari |
| 16 Jan 22 | r15        | Bidco UnitedBidco United | 1 - 1 | SofapakaSofapaka |
| 16 Jan 22 | r15        | KCBKCB | 2 - 3 | HomeboyzHomeboyz |
| 16 Jan 22 | r15        | TuskerTusker | 0 - 1 | Nairobi City StarsNairobi City |
| 16 Jan 22 | r15        | Wazito FCWazito FC | 2 - 1 | Nzoia SugarNzoia Sugar |
| 23 Jan 22 | r15        | AFC LeopardsAFC Leopards | 1 - 2 | Mathare UnitedMathare Unite |
| 23 Jan 22 | r15        | KCBKCB | 2 - 1 | Posta Rangers FCPosta Rangers |
| 12 Feb 22 | r15        | Wazito FCWazito FC | 1 - 2 | SofapakaSofapaka |
| 06 Mar 22 | r15        | Vihiga BulletsVihiga Bullet | 2 - 1 | TalantaTalanta |
| 06 Mar 22 | r15        | BandariBandari | 2 - 2 | AFC LeopardsAFC Leopards |
| 09 Mar 22 | r15        | SofapakaSofapaka | 1 - 1 | GOR MahiaGOR Mahia |
| 13 Mar 22 | r15        | BandariBandari | 2 - 1 | HomeboyzHomeboyz |
| 02 Apr 22 | r15        | KCBKCB | 1 - 1 | TuskerTusker |
| 16 Apr 22 | r15        | TuskerTusker | 0 - 2 | GOR MahiaGOR Mahia |
| 24 Apr 22 | r15        | Mathare UnitedMathare Unite | - | BandariBandari |
| 07 May 22 | r15        | Bidco UnitedBidco United | 0 - 1 | Ulinzi StarsUlinzi Stars |
| 08 May 22 | r15        | Vihiga BulletsVihiga Bullet | 3 - 4 | Kariobangi SharksKariobangi Sh |
| 09 May 22 | r15        | Nairobi City StarsNairobi City | 0 - 1 | Wazito FCWazito FC |
| 15 May 22 | r15        | Wazito FCWazito FC | 0 - 1 | Nzoia SugarNzoia Sugar |
| 21 May 22 | r15        | Bidco UnitedBidco United | 0 - 1 | Kenya PoliceKenya Police |
| 29 May 22 | r15        | GOR MahiaGOR Mahia | 2 - 3 | Nairobi City StarsNairobi City |