| 03 Sep 21 | r01  | Trat FCTrat FC | 2 - 0 | Nakhon Pathom UnitedNakhon Pathom |
| |
| 12 Sep 21 | r02 | Nakhon Pathom UnitedNakhon Pathom | 1 - 1 | Lampang FCLampang FC |
| |
| 15 Sep 21 | r03 | Nakhon Pathom UnitedNakhon Pathom | 1 - 1 | Raj PrachaRaj Pracha |
| |
| 19 Sep 21 | r04 | Navy FCNavy FC | 2 - 3 | Nakhon Pathom UnitedNakhon Pathom |
| |
| 26 Sep 21 | r05 | Nakhon Pathom UnitedNakhon Pathom | 2 - 2 | Udon ThaniUdon Thani |
| |
| 03 Oct 21 | r06 | Ayutthaya FCAyutthaya FC | 2 - 2 | Nakhon Pathom UnitedNakhon Pathom |
| |
| 09 Oct 21 | r07 | Nakhon Pathom UnitedNakhon Pathom | 1 - 4 | Rayong FCRayong FC |
| |
| 13 Oct 21 | r08 | KhonkaenKhonkaen | 1 - 0 | Nakhon Pathom UnitedNakhon Pathom |
| |
| 17 Oct 21 | r09 | Nakhon Pathom UnitedNakhon Pathom | 4 - 4 | Customs UnitedCustoms Unite |
| |
| 23 Oct 21 | r10 | Kasetsart FCKasetsart FC | 1 - 0 | Nakhon Pathom UnitedNakhon Pathom |
| |
| 31 Oct 21 | r11 | Nakhon Pathom UnitedNakhon Pathom | 0 - 0 | Lamphun WarriorLamphun Warri |
| |
| 07 Nov 21 | r12 | Sukhothai FCSukhothai FC | 2 - 1 | Nakhon Pathom UnitedNakhon Pathom |
| |
| 13 Nov 21 | r13 | Nakhon Pathom UnitedNakhon Pathom | 0 - 1 | ChainatChainat |
| |
| 17 Nov 21 | r14 | Muangkan UnitedMuangkan Unit | 1 - 2 | Nakhon Pathom UnitedNakhon Pathom |
| |
| 20 Nov 21 | r15  | Nakhon Pathom UnitedNakhon Pathom | 1 - 2 | Ranong UnitedRanong United |
| |
| 28 Nov 21 | r16 | Chiangmai FCChiangmai FC | 1 - 0 | Nakhon Pathom UnitedNakhon Pathom |
| |
| 04 Dec 21 | r17 | Nakhon Pathom UnitedNakhon Pathom | 2 - 1 | Phrae UnitedPhrae United |
| |
| 08 Jan 22 | r18 | Lampang FCLampang FC | 1 - 1 | Nakhon Pathom UnitedNakhon Pathom |
| |
| 16 Jan 22 | r19 | Raj PrachaRaj Pracha | 2 - 1 | Nakhon Pathom UnitedNakhon Pathom |
| |
| 22 Jan 22 | r20 | Nakhon Pathom UnitedNakhon Pathom | 3 - 2 | Navy FCNavy FC |
| |
| 29 Jan 22 | r21 | Udon ThaniUdon Thani | 0 - 4 | Nakhon Pathom UnitedNakhon Pathom |
| |
| 06 Feb 22 | r22 | Nakhon Pathom UnitedNakhon Pathom | 0 - 0 | Ayutthaya FCAyutthaya FC |
| |
| 12 Feb 22 | r23 | Rayong FCRayong FC | 0 - 0 | Nakhon Pathom UnitedNakhon Pathom |
| |
| 19 Feb 22 | r24 | Nakhon Pathom UnitedNakhon Pathom | 1 - 0 | KhonkaenKhonkaen |
| |
| 27 Feb 22 | r25 | Customs UnitedCustoms Unite | 0 - 1 | Nakhon Pathom UnitedNakhon Pathom |
| |
| 06 Mar 22 | r26 | Nakhon Pathom UnitedNakhon Pathom | 1 - 0 | Kasetsart FCKasetsart FC |
| |
| 13 Mar 22 | r27 | Lamphun WarriorLamphun Warri | 3 - 1 | Nakhon Pathom UnitedNakhon Pathom |
| |
| 19 Mar 22 | r28 | Nakhon Pathom UnitedNakhon Pathom | 1 - 0 | Sukhothai FCSukhothai FC |
| |
| 25 Mar 22 | r29 | ChainatChainat | 3 - 0 | Nakhon Pathom UnitedNakhon Pathom |
| |
| 03 Apr 22 | r30 | Nakhon Pathom UnitedNakhon Pathom | 4 - 4 | Muangkan UnitedMuangkan Unit |
| |
| 09 Apr 22 | r31 | Ranong UnitedRanong United | 0 - 1 | Nakhon Pathom UnitedNakhon Pathom |
| |
| 16 Apr 22 | r32 | Nakhon Pathom UnitedNakhon Pathom | 1 - 2 | Chiangmai FCChiangmai FC |
| |
| 23 Apr 22 | r33 | Phrae UnitedPhrae United | 1 - 1 | Nakhon Pathom UnitedNakhon Pathom |
| |
| 30 Apr 22 | r34 | Nakhon Pathom UnitedNakhon Pathom | 1 - 1 | Trat FCTrat FC |
Team 2021-2022 Schedules
Bangkok
Chainat Hornbill
Chanthaburi
Chiangmai United
Kasetsart
Khon Kaen United
Mahasarakham
Nakhon Pathom United
Nakhonsi United
Nongbua Pitchaya
Pattani
Pattaya United
Phrae United
Police Tero
Rasisalai United
Sisaket United
Songkhla
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