| 05 Sep 21 | r01  | Lamphun WarriorLamphun Warri | 1 - 0 | Kasetsart FCKasetsart FC |
| |
| 11 Sep 21 | r02 | Kasetsart FCKasetsart FC | 1 - 0 | Ranong UnitedRanong United |
| |
| 15 Sep 21 | r19 | Kasetsart FCKasetsart FC | 0 - 0 | Chiangmai FCChiangmai FC |
| |
| 18 Sep 21 | r04 | Kasetsart FCKasetsart FC | 1 - 2 | Lampang FCLampang FC |
| |
| 26 Sep 21 | r05 | Muangkan UnitedMuangkan Unit | 1 - 2 | Kasetsart FCKasetsart FC |
| |
| 03 Oct 21 | r06 | Kasetsart FCKasetsart FC | 0 - 4 | ChainatChainat |
| |
| 09 Oct 21 | r07 | Navy FCNavy FC | 0 - 0 | Kasetsart FCKasetsart FC |
| |
| 13 Oct 21 | r08 | Kasetsart FCKasetsart FC | 0 - 1 | Phrae UnitedPhrae United |
| |
| 16 Oct 21 | r09 | Trat FCTrat FC | 1 - 0 | Kasetsart FCKasetsart FC |
| 16 Oct 21 | r09 | Trat FCTrat FC | 1 - 0 | Kasetsart FCKasetsart FC |
| |
| 23 Oct 21 | r10 | Kasetsart FCKasetsart FC | 1 - 0 | Nakhon Pathom UnitedNakhon Pathom |
| |
| 30 Oct 21 | r11 | Raj PrachaRaj Pracha | 1 - 1 | Kasetsart FCKasetsart FC |
| |
| 06 Nov 21 | r12 | Kasetsart FCKasetsart FC | 2 - 2 | Udon ThaniUdon Thani |
| |
| 14 Nov 21 | r13 | Rayong FCRayong FC | 1 - 2 | Kasetsart FCKasetsart FC |
| |
| 17 Nov 21 | r14 | Kasetsart FCKasetsart FC | 0 - 2 | Ayutthaya FCAyutthaya FC |
| |
| 21 Nov 21 | r15 | Kasetsart FCKasetsart FC | 1 - 1 | Customs UnitedCustoms Unite |
| |
| 28 Nov 21 | r16  | Sukhothai FCSukhothai FC | 2 - 2 | Kasetsart FCKasetsart FC |
| |
| 05 Dec 21 | r17 | Kasetsart FCKasetsart FC | 2 - 1 | KhonkaenKhonkaen |
| |
| 08 Jan 22 | r18 | Ranong UnitedRanong United | 0 - 0 | Kasetsart FCKasetsart FC |
| |
| 15 Jan 22 | r03 | Chiangmai FCChiangmai FC | 2 - 0 | Kasetsart FCKasetsart FC |
| |
| 22 Jan 22 | r20 | Lampang FCLampang FC | 5 - 1 | Kasetsart FCKasetsart FC |
| |
| 29 Jan 22 | r21 | Kasetsart FCKasetsart FC | 2 - 2 | Muangkan UnitedMuangkan Unit |
| |
| 06 Feb 22 | r22 | ChainatChainat | 3 - 2 | Kasetsart FCKasetsart FC |
| |
| 13 Feb 22 | r23 | Kasetsart FCKasetsart FC | 1 - 0 | Navy FCNavy FC |
| |
| 19 Feb 22 | r24 | Phrae UnitedPhrae United | 0 - 0 | Kasetsart FCKasetsart FC |
| |
| 27 Feb 22 | r25 | Kasetsart FCKasetsart FC | 2 - 0 | Trat FCTrat FC |
| |
| 06 Mar 22 | r26 | Nakhon Pathom UnitedNakhon Pathom | 1 - 0 | Kasetsart FCKasetsart FC |
| |
| 13 Mar 22 | r27 | Kasetsart FCKasetsart FC | 3 - 2 | Raj PrachaRaj Pracha |
| |
| 18 Mar 22 | r28 | Udon ThaniUdon Thani | 1 - 2 | Kasetsart FCKasetsart FC |
| |
| 27 Mar 22 | r29 | Kasetsart FCKasetsart FC | 1 - 1 | Rayong FCRayong FC |
| |
| 03 Apr 22 | r30 | Ayutthaya FCAyutthaya FC | 1 - 1 | Kasetsart FCKasetsart FC |
| |
| 10 Apr 22 | r31 | Customs UnitedCustoms Unite | 2 - 1 | Kasetsart FCKasetsart FC |
| |
| 17 Apr 22 | r32 | Kasetsart FCKasetsart FC | 1 - 4 | Sukhothai FCSukhothai FC |
| |
| 23 Apr 22 | r33 | KhonkaenKhonkaen | 0 - 0 | Kasetsart FCKasetsart FC |
| |
| 30 Apr 22 | r34 | Kasetsart FCKasetsart FC | 0 - 3 | Lamphun WarriorLamphun Warri |
Team 2021-2022 Schedules
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Chanthaburi
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Kasetsart
Khon Kaen United
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Nakhon Pathom United
Nakhonsi United
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Pattani
Pattaya United
Phrae United
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Sisaket United
Songkhla
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