| 06 Mar 21 | r00  | Coventry R.F.C.Coventry R.F. | 10 - 9 | Bedford BluesBedford Blues |
| 12 Mar 21 | r00 | Bedford BluesBedford Blues | 33 - 25 | Hartpury University R.F.CHartpury Univ |
| 21 Mar 21 | r00 | Cornish PiratesCornish Pirat | 27 - 12 | Bedford BluesBedford Blues |
| 27 Mar 21 | r00 | Bedford BluesBedford Blues | 20 - 25 | Jersey RedsJersey Reds |
| 17 Apr 21 | r00 | Bedford BluesBedford Blues | 38 - 10 | Richmond F.C.Richmond F.C. |
| 02 May 21 | r00 | Doncaster KnightsDoncaster Kni | 27 - 19 | Bedford BluesBedford Blues |
| 14 May 21 | r00 | Bedford BluesBedford Blues | 17 - 40 | Ealing TrailfindersEaling Trailf |
| 23 May 21 | r00 | Nottingham R.F.C.Nottingham R. | 22 - 20 | Bedford BluesBedford Blues |
| 29 May 21 | r00 | Bedford BluesBedford Blues | 32 - 28 | Ampthill RUFCAmpthill RUFC |
| 25 Sep 21 | r00 | Jersey RedsJersey Reds | 40 - 28 | Bedford BluesBedford Blues |
| 01 Oct 21 | r00 | Bedford BluesBedford Blues | 31 - 23 | Doncaster KnightsDoncaster Kni |
| 09 Oct 21 | r00 | Ampthill RUFCAmpthill RUFC | 34 - 53 | Bedford BluesBedford Blues |
| 23 Oct 21 | r00 | Bedford BluesBedford Blues | 32 - 37 | Richmond F.C.Richmond F.C. |
| 30 Oct 21 | r00 | Hartpury University R.F.CHartpury Univ | 19 - 42 | Bedford BluesBedford Blues |
| 06 Nov 21 | r00 | Bedford BluesBedford Blues | 14 - 50 | Ealing TrailfindersEaling Trailf |
| 20 Nov 21 | r00 | Cornish PiratesCornish Pirat | 39 - 24 | Bedford BluesBedford Blues |
| 27 Nov 21 | r00 | Bedford BluesBedford Blues | 40 - 9 | Nottingham R.F.C.Nottingham R. |
| 04 Dec 21 | r00 | Coventry R.F.C.Coventry R.F. | 15 - 14 | Bedford BluesBedford Blues |
| 11 Dec 21 | r00 | Bedford BluesBedford Blues | 24 - 19 | London ScottishLondon Scotti |
| 26 Dec 21 | r00 | Bedford BluesBedford Blues | 28 - 19 | Jersey RedsJersey Reds |
| 15 Jan 22 | r00 | Bedford BluesBedford Blues | 10 - 20 | Ampthill RUFCAmpthill RUFC |
| 22 Jan 22 | r00 | Richmond F.C.Richmond F.C. | 22 - 19 | Bedford BluesBedford Blues |
| 29 Jan 22 | r00 | Bedford BluesBedford Blues | 10 - 34 | Hartpury University R.F.CHartpury Univ |
| 05 Feb 22 | r00 | Doncaster KnightsDoncaster Kni | 24 - 0 | Bedford BluesBedford Blues |
| 12 Feb 22 | r00 | Ealing TrailfindersEaling Trailf | 19 - 31 | Bedford BluesBedford Blues |
| 19 Feb 22 | r00 | Bedford BluesBedford Blues | 12 - 20 | Cornish PiratesCornish Pirat |
| 27 Feb 22 | r00 | Nottingham R.F.C.Nottingham R. | 22 - 47 | Bedford BluesBedford Blues |
| 11 Mar 22 | r00 | Bedford BluesBedford Blues | 15 - 17 | Coventry R.F.C.Coventry R.F. |
| 19 Mar 22 | r00 | London ScottishLondon Scotti | 21 - 62 | Bedford BluesBedford Blues |
Team 2021-2022 Schedules
Ampthill RUFC
Bedford Blues
Caldy Rugby Football Club
Cambridge RUFC
Chinnor RFC
Cornish Pirates
Coventry R.F.C.
Doncaster Knights
Ealing Trailfinders
Hartpury University R.F.C.
London Scottish
Nottingham R.F.C.
Richmond F.C.
Worcester Warriors
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