| 07 Mar 21 | r00  | Ampthill RUFCAmpthill RUFC | 17 - 19 | Doncaster KnightsDoncaster Kni |
| 13 Mar 21 | r00 | Ealing TrailfindersEaling Trailf | 54 - 6 | Ampthill RUFCAmpthill RUFC |
| 21 Mar 21 | r00 | Ampthill RUFCAmpthill RUFC | 31 - 15 | Nottingham R.F.C.Nottingham R. |
| 11 Apr 21 | r00 | Coventry R.F.C.Coventry R.F. | 26 - 15 | Ampthill RUFCAmpthill RUFC |
| 18 Apr 21 | r00 | Ampthill RUFCAmpthill RUFC | 43 - 41 | Hartpury University R.F.CHartpury Univ |
| 24 Apr 21 | r00 | Cornish PiratesCornish Pirat | 18 - 20 | Ampthill RUFCAmpthill RUFC |
| 01 May 21 | r00 | Ampthill RUFCAmpthill RUFC | 14 - 29 | Jersey RedsJersey Reds |
| 23 May 21 | r00 | Ampthill RUFCAmpthill RUFC | 31 - 22 | Richmond F.C.Richmond F.C. |
| 29 May 21 | r00 | Bedford BluesBedford Blues | 32 - 28 | Ampthill RUFCAmpthill RUFC |
| 17 Sep 21 | r00 | Nottingham R.F.C.Nottingham R. | 36 - 26 | Ampthill RUFCAmpthill RUFC |
| 25 Sep 21 | r00 | Ampthill RUFCAmpthill RUFC | 21 - 19 | Coventry R.F.C.Coventry R.F. |
| 02 Oct 21 | r00 | London ScottishLondon Scotti | 13 - 22 | Ampthill RUFCAmpthill RUFC |
| 09 Oct 21 | r00 | Ampthill RUFCAmpthill RUFC | 34 - 53 | Bedford BluesBedford Blues |
| 23 Oct 21 | r00 | Jersey RedsJersey Reds | 17 - 17 | Ampthill RUFCAmpthill RUFC |
| 30 Oct 21 | r00 | Ampthill RUFCAmpthill RUFC | 18 - 20 | Doncaster KnightsDoncaster Kni |
| 20 Nov 21 | r00 | Richmond F.C.Richmond F.C. | 36 - 38 | Ampthill RUFCAmpthill RUFC |
| 27 Nov 21 | r00 | Ampthill RUFCAmpthill RUFC | 24 - 39 | Hartpury University R.F.CHartpury Univ |
| 04 Dec 21 | r00 | Ealing TrailfindersEaling Trailf | 54 - 17 | Ampthill RUFCAmpthill RUFC |
| 11 Dec 21 | r00 | Ampthill RUFCAmpthill RUFC | 13 - 26 | Cornish PiratesCornish Pirat |
| 18 Dec 21 | r00 | Ampthill RUFCAmpthill RUFC | 20 - 15 | Nottingham R.F.C.Nottingham R. |
| 26 Dec 21 | r00 | Coventry R.F.C.Coventry R.F. | 26 - 22 | Ampthill RUFCAmpthill RUFC |
| 01 Jan 22 | r00 | Ampthill RUFCAmpthill RUFC | 36 - 17 | London ScottishLondon Scotti |
| 15 Jan 22 | r00 | Bedford BluesBedford Blues | 10 - 20 | Ampthill RUFCAmpthill RUFC |
| 22 Jan 22 | r00 | Ampthill RUFCAmpthill RUFC | 12 - 17 | Jersey RedsJersey Reds |
| 29 Jan 22 | r00 | Doncaster KnightsDoncaster Kni | 19 - 13 | Ampthill RUFCAmpthill RUFC |
| 19 Feb 22 | r00 | Ampthill RUFCAmpthill RUFC | 13 - 8 | Richmond F.C.Richmond F.C. |
| 26 Feb 22 | r00 | Hartpury University R.F.CHartpury Univ | 20 - 21 | Ampthill RUFCAmpthill RUFC |
| 12 Mar 22 | r00 | Ampthill RUFCAmpthill RUFC | 5 - 38 | Ealing TrailfindersEaling Trailf |
| 02 Apr 22 | r00 | Cornish PiratesCornish Pirat | 28 - 28 | Ampthill RUFCAmpthill RUFC |
Team 2021-2022 Schedules
Ampthill RUFC
Bedford Blues
Caldy Rugby Football Club
Cambridge RUFC
Chinnor RFC
Cornish Pirates
Coventry R.F.C.
Doncaster Knights
Ealing Trailfinders
Hartpury University R.F.C.
London Scottish
Nottingham R.F.C.
Richmond F.C.
Worcester Warriors
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