| 16 Feb 22 | r16     | Santos de GuápilesSantos de Guá | 0 - 2 | New York CityNew York City |
| 16 Feb 22 | r16 | SantosSantos | 1 - 0 | CF MontréalCF Montréal |
| 16 Feb 22 | r16 | CD GuastatoyaCD Guastatoya | 0 - 2 | LeonLeon |
| 17 Feb 22 | r16 | Forge FCForge FC | 0 - 1 | Cruz AzulCruz Azul |
| 17 Feb 22 | r16 | Deportivo SaprissaDeportivo Sap | 2 - 2 | PumasPumas |
| 17 Feb 22 | r16 | CavalyCavaly | - | New England Rev.New England R |
| 18 Feb 22 | r16 | ComunicacionesComunicacione | 1 - 0 | Colorado RapidsColorado Rapi |
| 18 Feb 22 | r16 | MotaguaMotagua | 0 - 0 | Seattle Sounders FCSeattle Sound |
| 22 Feb 22 | r16 | New England Rev.New England R | - | CavalyCavaly |
| 23 Feb 22 | r16 | LeonLeon | 1 - 0 | CD GuastatoyaCD Guastatoya |
| 23 Feb 22 | r16 | New York CityNew York City | 4 - 0 | Santos de GuápilesSantos de Guá |
| 24 Feb 22 | r16 | CF MontréalCF Montréal | 3 - 0 | SantosSantos |
| 24 Feb 22 | r16 | Colorado RapidsColorado Rapi | 1 - 0 | ComunicacionesComunicacione |
| 24 Feb 22 | r16 | PumasPumas | 4 - 1 | Deportivo SaprissaDeportivo Sap |
| 25 Feb 22 | r16 | Cruz AzulCruz Azul | 3 - 1 | Forge FCForge FC |
| 25 Feb 22 | r16 | Seattle Sounders FCSeattle Sound | 5 - 0 | MotaguaMotagua |
| |
| 09 Mar 22 | QF | New York CityNew York City | 3 - 1 | ComunicacionesComunicacione |
| 09 Mar 22 | QF | Seattle Sounders FCSeattle Sound | 3 - 0 | LeonLeon |
| 10 Mar 22 | QF  | New England Rev.New England R | 3 - 0 | PumasPumas |
| 10 Mar 22 | QF | Cruz AzulCruz Azul | 1 - 0 | CF MontréalCF Montréal |
| 16 Mar 22 | QF | ComunicacionesComunicacione | 4 - 2 | New York CityNew York City |
| 17 Mar 22 | QF | CF MontréalCF Montréal | 1 - 1 | Cruz AzulCruz Azul |
| 17 Mar 22 | QF | PumasPumas | 3 - 0 | New England Rev.New England R |
| 18 Mar 22 | QF | LeonLeon | 1 - 1 | Seattle Sounders FCSeattle Sound |
| |
| 06 Apr 22 | SF | PumasPumas | 2 - 1 | Cruz AzulCruz Azul |
| 07 Apr 22 | SF | Seattle Sounders FCSeattle Sound | 3 - 1 | New York CityNew York City |
| 13 Apr 22 | SF | Cruz AzulCruz Azul | 0 - 0 | PumasPumas |
| 14 Apr 22 | SF | New York CityNew York City | 1 - 1 | Seattle Sounders FCSeattle Sound |
| |
| 28 Apr 22 | Final | PumasPumas | 2 - 2 | Seattle Sounders FCSeattle Sound |
| 05 May 22 | Final | Seattle Sounders FCSeattle Sound | 3 - 0 | PumasPumas |
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