| 09 Sep 22 | Qualifier        | Banjul Hawks FCBanjul Hawks | 0 - 0 | Horoya ACHoroya AC |
| 10 Sep 22 | Qualifier        | Volcan ClubVolcan Club | 1 - 0 | La PasseLa Passe |
| 10 Sep 22 | Qualifier        | Red ArrowsRed Arrows | 0 - 1 | Primeiro de AgostoPrimeiro de A |
| 10 Sep 22 | Qualifier        | MatlamaMatlama | 0 - 3 | Coton Sport FC de GarouaCoton Sport F |
| 10 Sep 22 | Qualifier        | Nyasa Big BulletsNyasa Big Bul | 0 - 2 | Simba SCSimba SC |
| 10 Sep 22 | Qualifier        | ZalanZalan | 0 - 4 | Young AfricansYoung African |
| 10 Sep 22 | Qualifier        | APRAPR | 1 - 0 | US MonastirUS Monastir |
| 10 Sep 22 | Qualifier        | Cape Town CityCape Town Cit | 2 - 0 | AS OtohôAS Otohô |
| 10 Sep 22 | Qualifier        | KMKM FCKMKM FC | 0 - 2 | Al Ahli TripoliAl Ahli Tripo |
| 10 Sep 22 | Qualifier        | Stade MandjiStade Mandji | 2 - 2 | Plateau UnitedPlateau Unite |
| 10 Sep 22 | Qualifier        | Olympic Real de BanguiOlympic Real | 0 - 3 | VipersVipers |
| 10 Sep 22 | Qualifier        | Deportivo MongomoDeportivo Mon | 2 - 0 | DjolibaDjoliba |
| 10 Sep 22 | Qualifier        | NigelecNigelec | 2 - 1 | CO CoyahCO Coyah |
| 10 Sep 22 | Qualifier        | Bo RangersBo Rangers | 0 - 0 | CR BelouizdadCR Belouizdad |
| 11 Sep 22 | Qualifier        | CFFACFFA | 2 - 3 | Royal LeopardsRoyal Leopard |
| 11 Sep 22 | Qualifier        | Kidus GiorgisKidus Giorgis | 2 - 1 | Al-Hilal OmdurmanAl-Hilal Omdu |
| 11 Sep 22 | Qualifier        | Associação Black BullsAssociação Bl | 0 - 3 | Atlético PetróleosAtlético Petr |
| 11 Sep 22 | Qualifier        | Flambeau du CentreFlambeau du C | 1 - 0 | Al-Ittihad TripoliAl-Ittihad Tr |
| 11 Sep 22 | Qualifier        | AS ArtaAS Arta | 1 - 2 | Al-MerrikhAl-Merrikh |
| 11 Sep 22 | Qualifier        | Rivers UnitedRivers United | 3 - 0 | WatangaWatanga |
| 11 Sep 22 | Qualifier        | Coton Sport OuidahCoton Sport O | 1 - 2 | ASEC MimosasASEC Mimosas |
| 11 Sep 22 | Qualifier        | ASC KaraASC Kara | 1 - 1 | NouadhibouNouadhibou |
| 11 Sep 22 | Qualifier        | Gaborone UnitedGaborone Unit | 1 - 0 | Vita ClubVita Club |
| 11 Sep 22 | Qualifier        | Casa SportCasa Sport | 1 - 0 | JS KabylieJS Kabylie |
| 12 Sep 22 | Qualifier        | Rail Club du KadiogoRail Club du | 0 - 1 | Asante KotokoAsante Kotoko |
| 16 Sep 22 | Qualifier        | Horoya ACHoroya AC | - | Banjul Hawks FCBanjul Hawks |
| 16 Sep 22 | Qualifier        | La PasseLa Passe | 0 - 1 | Volcan ClubVolcan Club |
| 16 Sep 22 | Qualifier        | CO CoyahCO Coyah | 0 - 0 | NigelecNigelec |
| 17 Sep 22 | Qualifier        | Al-MerrikhAl-Merrikh | 0 - 0 | AS ArtaAS Arta |
| 17 Sep 22 | Qualifier        | Royal LeopardsRoyal Leopard | 2 - 1 | CFFACFFA |
| 17 Sep 22 | Qualifier        | VipersVipers | 1 - 0 | Olympic Real de BanguiOlympic Real |
| 17 Sep 22 | Qualifier        | Atlético PetróleosAtlético Petr | 2 - 1 | Associação Black BullsAssociação Bl |
| 17 Sep 22 | Qualifier        | Young AfricansYoung African | 5 - 0 | ZalanZalan |
| 17 Sep 22 | Qualifier        | Al Ahli TripoliAl Ahli Tripo | 4 - 0 | KMKM FCKMKM FC |
| 17 Sep 22 | Qualifier        | CR BelouizdadCR Belouizdad | 3 - 0 | Bo RangersBo Rangers |
| 17 Sep 22 | Qualifier        | NouadhibouNouadhibou | 0 - 1 | ASC KaraASC Kara |
| 18 Sep 22 | Qualifier        | Simba SCSimba SC | 2 - 0 | Nyasa Big BulletsNyasa Big Bul |
| 18 Sep 22 | Qualifier        | US MonastirUS Monastir | 3 - 0 | APRAPR |
| 18 Sep 22 | Qualifier        | Vita ClubVita Club | 3 - 1 | Gaborone UnitedGaborone Unit |
| 18 Sep 22 | Qualifier        | AS OtohôAS Otohô | 0 - 0 | Cape Town CityCape Town Cit |
| 18 Sep 22 | Qualifier        | TP Elect-SportTP Elect-Spor | 0 - 2 | Zamalek SCZamalek SC |
| 18 Sep 22 | Qualifier        | Asante KotokoAsante Kotoko | 0 - 1 | Rail Club du KadiogoRail Club du |
| 18 Sep 22 | Qualifier        | Plateau UnitedPlateau Unite | 1 - 0 | Stade MandjiStade Mandji |
| 18 Sep 22 | Qualifier        | Primeiro de AgostoPrimeiro de A | 1 - 1 | Red ArrowsRed Arrows |
| 18 Sep 22 | Qualifier        | ASEC MimosasASEC Mimosas | 2 - 0 | Coton Sport OuidahCoton Sport O |
| 18 Sep 22 | Qualifier        | WatangaWatanga | 1 - 0 | Rivers UnitedRivers United |
| 18 Sep 22 | Qualifier        | Coton Sport FC de GarouaCoton Sport F | 1 - 0 | MatlamaMatlama |
| 18 Sep 22 | Qualifier        | Al-Ittihad TripoliAl-Ittihad Tr | 2 - 1 | Flambeau du CentreFlambeau du C |
| 18 Sep 22 | Qualifier        | Al-Hilal OmdurmanAl-Hilal Omdu | 1 - 0 | Kidus GiorgisKidus Giorgis |
| 18 Sep 22 | Qualifier        | JS KabylieJS Kabylie | 3 - 0 | Casa SportCasa Sport |
| 19 Sep 22 | Qualifier        | DjolibaDjoliba | 5 - 0 | Deportivo MongomoDeportivo Mon |
| 25 Sep 22 | Qualifier        | Zamalek SCZamalek SC | 2 - 0 | TP Elect-SportTP Elect-Spor |
| 07 Oct 22 | Qualifier        | Al-MerrikhAl-Merrikh | 2 - 0 | Al Ahli TripoliAl Ahli Tripo |
| 08 Oct 22 | Qualifier        | Young AfricansYoung African | 1 - 1 | Al-Hilal OmdurmanAl-Hilal Omdu |
| 08 Oct 22 | Qualifier        | ASC KaraASC Kara | 1 - 2 | JS KabylieJS Kabylie |
| 08 Oct 22 | Qualifier        | NigelecNigelec | 0 - 2 | Raja CasablancaRaja Casablan |
| 08 Oct 22 | Qualifier        | Cape Town CityCape Town Cit | 0 - 3 | Atlético PetróleosAtlético Petr |
| 09 Oct 22 | Qualifier        | VipersVipers | 0 - 0 | TP MazembeTP Mazembe |
| 09 Oct 22 | Qualifier        | Royal LeopardsRoyal Leopard | 1 - 1 | Coton Sport FC de GarouaCoton Sport F |
| 09 Oct 22 | Qualifier        | Volcan ClubVolcan Club | 0 - 7 | Mamelodi SundownsMamelodi Sund |
| 09 Oct 22 | Qualifier        | US MonastirUS Monastir | 0 - 1 | Al Ahly SCAl Ahly SC |
| 09 Oct 22 | Qualifier        | Primeiro de AgostoPrimeiro de A | 1 - 3 | Simba SCSimba SC |
| 09 Oct 22 | Qualifier        | Plateau UnitedPlateau Unite | 2 - 1 | Espérance de TunisEspérance de |
| 09 Oct 22 | Qualifier        | Rivers UnitedRivers United | 2 - 1 | Wydad CasablancaWydad Casabla |
| 09 Oct 22 | Qualifier        | ASEC MimosasASEC Mimosas | 0 - 1 | Horoya ACHoroya AC |
| 09 Oct 22 | Qualifier        | DjolibaDjoliba | 2 - 1 | CR BelouizdadCR Belouizdad |
| 09 Oct 22 | Qualifier        | Flambeau du CentreFlambeau du C | 0 - 1 | Zamalek SCZamalek SC |
| 14 Oct 22 | Qualifier        | Atlético PetróleosAtlético Petr | 1 - 0 | Cape Town CityCape Town Cit |
| 14 Oct 22 | Qualifier        | Mamelodi SundownsMamelodi Sund | 8 - 1 | Volcan ClubVolcan Club |
| 14 Oct 22 | Qualifier        | Zamalek SCZamalek SC | 5 - 1 | Flambeau du CentreFlambeau du C |
| 14 Oct 22 | Qualifier        | CR BelouizdadCR Belouizdad | 2 - 0 | DjolibaDjoliba |
| 15 Oct 22 | Qualifier        | TP MazembeTP Mazembe | 0 - 0 | VipersVipers |
| 15 Oct 22 | Qualifier        | Al Ahly SCAl Ahly SC | 3 - 0 | US MonastirUS Monastir |
| 15 Oct 22 | Qualifier        | Espérance de TunisEspérance de | 1 - 0 | Plateau UnitedPlateau Unite |
| 15 Oct 22 | Qualifier        | Raja CasablancaRaja Casablan | 1 - 0 | NigelecNigelec |
| 15 Oct 22 | Qualifier        | Al Ahli TripoliAl Ahli Tripo | 3 - 1 | Al-MerrikhAl-Merrikh |
| 15 Oct 22 | Qualifier        | JS KabylieJS Kabylie | 1 - 1 | ASC KaraASC Kara |
| 16 Oct 22 | Qualifier        | Simba SCSimba SC | 1 - 0 | Primeiro de AgostoPrimeiro de A |
| 16 Oct 22 | Qualifier        | Rail Club du KadiogoRail Club du | 0 - 0 | Vita ClubVita Club |
| 16 Oct 22 | Qualifier        | Horoya ACHoroya AC | 1 - 1 | ASEC MimosasASEC Mimosas |
| 16 Oct 22 | Qualifier        | Coton Sport FC de GarouaCoton Sport F | 2 - 1 | Royal LeopardsRoyal Leopard |
| 16 Oct 22 | Qualifier        | Al-Hilal OmdurmanAl-Hilal Omdu | 1 - 0 | Young AfricansYoung African |
| 16 Oct 22 | Qualifier        | Wydad CasablancaWydad Casabla | 6 - 0 | Rivers UnitedRivers United |
| 20 Oct 22 | Qualifier        | Vita ClubVita Club | 0 - 0 | Rail Club du KadiogoRail Club du |