| 14 Sep 19 | r02        | Côte d-'Or FCCôte d-'Or FC | 0 - 5 | Mamelodi SundownsMamelodi Sund |
| 14 Sep 19 | r02        | Green EaglesGreen Eagles | 1 - 2 | Primeiro de AgostoPrimeiro de A |
| 14 Sep 19 | r02        | Young AfricansYoung African | 1 - 1 | ZESCO UnitedZESCO United |
| 14 Sep 19 | r02        | FC PlatinumFC Platinum | 1 - 0 | UD SongoUD Songo |
| 14 Sep 19 | r02        | Atlético PetróleosAtlético Petr | 0 - 0 | Kampala Capital City AuthKampala Capit |
| 14 Sep 19 | r02        | Cano SportCano Sport | 0 - 2 | Al Ahly SCAl Ahly SC |
| 14 Sep 19 | r02        | Génération FootGénération Fo | 2 - 1 | Zamalek SCZamalek SC |
| 14 Sep 19 | r02        | JS KabylieJS Kabylie | 2 - 0 | Horoya ACHoroya AC |
| 15 Sep 19 | r02        | Fosa JuniorsFosa Juniors | 0 - 0 | TP MazembeTP Mazembe |
| 15 Sep 19 | r02        | TP Elect-SportTP Elect-Spor | 1 - 1 | Espérance de TunisEspérance de |
| 15 Sep 19 | r02        | Asante KotokoAsante Kotoko | 2 - 0 | Étoile Sportive du SahelÉtoile Sporti |
| 15 Sep 19 | r02        | EnyimbaEnyimba | 0 - 0 | Al-Hilal OmdurmanAl-Hilal Omdu |
| 15 Sep 19 | r02        | ASC KaraASC Kara | 0 - 0 | Vita ClubVita Club |
| 15 Sep 19 | r02        | NouadhibouNouadhibou | 0 - 2 | Wydad CasablancaWydad Casabla |
| 15 Sep 19 | r02        | Al-Nasr SCSCAl-Nasr SCSC | 1 - 3 | Raja CasablancaRaja Casablan |
| 15 Sep 19 | r02        | USM AlgerUSM Alger | 4 - 1 | GOR MahiaGOR Mahia |
| 27 Sep 19 | r02        | Kampala Capital City AuthKampala Capit | 1 - 1 | Atlético PetróleosAtlético Petr |
| 27 Sep 19 | r02        | Mamelodi SundownsMamelodi Sund | 11 - 1 | Côte d-'Or FCCôte d-'Or FC |
| 27 Sep 19 | r02        | Espérance de TunisEspérance de | 2 - 1 | TP Elect-SportTP Elect-Spor |
| 28 Sep 19 | r02        | UD SongoUD Songo | 2 - 4 | FC PlatinumFC Platinum |
| 28 Sep 19 | r02        | ZESCO UnitedZESCO United | 2 - 1 | Young AfricansYoung African |
| 28 Sep 19 | r02        | Al Ahly SCAl Ahly SC | 4 - 0 | Cano SportCano Sport |
| 28 Sep 19 | r02        | Raja CasablancaRaja Casablan | 1 - 1 | Al-Nasr SCSCAl-Nasr SCSC |
| 29 Sep 19 | r02        | GOR MahiaGOR Mahia | 0 - 2 | USM AlgerUSM Alger |
| 29 Sep 19 | r02        | TP MazembeTP Mazembe | 3 - 1 | Fosa JuniorsFosa Juniors |
| 29 Sep 19 | r02        | Vita ClubVita Club | 1 - 0 | ASC KaraASC Kara |
| 29 Sep 19 | r02        | Horoya ACHoroya AC | 2 - 0 | JS KabylieJS Kabylie |
| 29 Sep 19 | r02        | Étoile Sportive du SahelÉtoile Sporti | 3 - 0 | Asante KotokoAsante Kotoko |
| 29 Sep 19 | r02        | Primeiro de AgostoPrimeiro de A | 0 - 1 | Green EaglesGreen Eagles |
| 29 Sep 19 | r02        | Al-Hilal OmdurmanAl-Hilal Omdu | 1 - 0 | EnyimbaEnyimba |
| 29 Sep 19 | r02        | Wydad CasablancaWydad Casabla | 4 - 1 | NouadhibouNouadhibou |
| 24 Oct 19 | r02        | Zamalek SCZamalek SC | 1 - 0 | Génération FootGénération Fo |