| 14 Aug 21 | r02  | Victoria RosportVictoria Rosp | 0 - 3 | FC 03 Differdange FC 03 Differd |
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| 18 Aug 21 | r01 | Progrès NiederkornProgrès Niede | 3 - 0 | FC 03 Differdange FC 03 Differd |
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| 22 Aug 21 | r03 | FC 03 Differdange FC 03 Differd | 1 - 1 | FolaFola |
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| 29 Aug 21 | r04 | UNA StrassenUNA Strassen | 0 - 1 | FC 03 Differdange FC 03 Differd |
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| 12 Sep 21 | r05 | FC 03 Differdange FC 03 Differd | 0 - 0 | Swift HesperangeSwift Hespera |
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| 19 Sep 21 | r06 | RodangeRodange | 1 - 4 | FC 03 Differdange FC 03 Differd |
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| 22 Sep 21 | r07 | FC 03 Differdange FC 03 Differd | 3 - 0 | RM Hamm BenficaRM Hamm Benfi |
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| 26 Sep 21 | r08 | WiltzWiltz | 2 - 1 | FC 03 Differdange FC 03 Differd |
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| 17 Oct 21 | r09 | FC 03 Differdange FC 03 Differd | 3 - 2 | F91 DudelangeF91 Dudelange |
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| 24 Oct 21 | r10 | Jeunesse EschJeunesse Esch | 0 - 0 | FC 03 Differdange FC 03 Differd |
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| 07 Nov 21 | r11 | FC 03 Differdange FC 03 Differd | 1 - 4 | HostertHostert |
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| 21 Nov 21 | r12 | Racing FC Union LuxembourRacing FC Uni | 3 - 1 | FC 03 Differdange FC 03 Differd |
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| 28 Nov 21 | r13 | FC 03 Differdange FC 03 Differd | 4 - 0 | UT PétangeUT Pétange |
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| 05 Dec 21 | r14 | Mondorf-les-BainsMondorf-les-B | 3 - 3 | FC 03 Differdange FC 03 Differd |
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| 12 Dec 21 | r15 | FC 03 Differdange FC 03 Differd | 4 - 0 | Etzella EttelbruckEtzella Ettel |
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| 06 Feb 22 | r16 | FC 03 Differdange FC 03 Differd | 4 - 0 | Victoria RosportVictoria Rosp |
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| 13 Feb 22 | r17 | FolaFola | 2 - 4 | FC 03 Differdange FC 03 Differd |
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| 20 Feb 22 | r18 | FC 03 Differdange FC 03 Differd | 2 - 1 | UNA StrassenUNA Strassen |
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| 27 Feb 22 | r19 | Swift HesperangeSwift Hespera | 3 - 0 | FC 03 Differdange FC 03 Differd |
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| 06 Mar 22 | r20 | FC 03 Differdange FC 03 Differd | 3 - 0 | RodangeRodange |
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| 13 Mar 22 | r21 | RM Hamm BenficaRM Hamm Benfi | 0 - 1 | FC 03 Differdange FC 03 Differd |
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| 20 Mar 22 | r22 | FC 03 Differdange FC 03 Differd | 3 - 1 | WiltzWiltz |
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| 03 Apr 22 | r23 | F91 DudelangeF91 Dudelange | 1 - 0 | FC 03 Differdange FC 03 Differd |
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| 10 Apr 22 | r24 | FC 03 Differdange FC 03 Differd | 1 - 0 | Jeunesse EschJeunesse Esch |
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| 16 Apr 22 | r25 | HostertHostert | 0 - 0 | FC 03 Differdange FC 03 Differd |
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| 24 Apr 22 | r26 | FC 03 Differdange FC 03 Differd | 4 - 0 | Racing FC Union LuxembourRacing FC Uni |
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| 01 May 22 | r27 | UT PétangeUT Pétange | 1 - 2 | FC 03 Differdange FC 03 Differd |
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| 08 May 22 | r28 | FC 03 Differdange FC 03 Differd | 1 - 0 | Mondorf-les-BainsMondorf-les-B |
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| 15 May 22 | r29 | Etzella EttelbruckEtzella Ettel | 0 - 2 | FC 03 Differdange FC 03 Differd |
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| 22 May 22 | r30 | FC 03 Differdange FC 03 Differd | 2 - 0 | Progrès NiederkornProgrès Niede |
Team 2021-2022 Schedules
Atert Bissen
Differdange 03
F91 Dudelange
Hostert
Jeunesse Canach
Jeunesse Esch
Käerjéng 97
Mamer 32
Mondorf-les-Bains
Progrès Niederkorn
Racing Union Luxembourg
Rodange
Swift Hesperange
UNA Strassen
Union Titus Pétange
Victoria Rosport
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