| 19 Feb 22 | r01     | Mushuc Runa SCMushuc Runa S | 1 - 2 | Universidad Católica del Universidad C |
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| 27 Feb 22 | r02 | 9 de Octubre9 de Octubre | 2 - 0 | Mushuc Runa SCMushuc Runa S |
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| 05 Mar 22 | r03 | Técnico UniversitarioTécnico Unive | 1 - 3 | Mushuc Runa SCMushuc Runa S |
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| 12 Mar 22 | r04 | Mushuc Runa SCMushuc Runa S | 4 - 2 | CumbayáCumbayá |
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| 20 Mar 22 | r05 | Mushuc Runa SCMushuc Runa S | 1 - 1 | Barcelona SCBarcelona SC |
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| 03 Apr 22 | r06 | Orense SCOrense SC | 0 - 0 | Mushuc Runa SCMushuc Runa S |
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| 09 Apr 22 | r07 | Mushuc Runa SCMushuc Runa S | 1 - 2 | Delfin SCDelfin SC |
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| 16 Apr 22 | r08 | GualaceoGualaceo | 3 - 2 | Mushuc Runa SCMushuc Runa S |
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| 21 Apr 22 | r09 | Mushuc Runa SCMushuc Runa S | 0 - 0 | CSD MacaráCSD Macará |
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| 24 Apr 22 | r10 | LDU QuitoLDU Quito | 3 - 2 | Mushuc Runa SCMushuc Runa S |
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| 30 Apr 22 | r11 | Mushuc Runa SCMushuc Runa S | 2 - 0 | Guayaquil City FCGuayaquil Cit |
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| 08 May 22 | r12 | EmelecEmelec | 4 - 0 | Mushuc Runa SCMushuc Runa S |
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| 14 May 22 | r13 | Mushuc Runa SCMushuc Runa S | 1 - 1 | SD AucasSD Aucas |
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| 23 May 22 | r14 | Independiente del ValleIndependiente | 0 - 1 | Mushuc Runa SCMushuc Runa S |
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| 28 May 22 | r15 | Mushuc Runa SCMushuc Runa S | 1 - 0 | Deportivo CuencaDeportivo Cue |
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| 09 Jul 22 | r01 | Universidad Católica del Universidad C | 2 - 1 | Mushuc Runa SCMushuc Runa S |
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| 17 Jul 22 | r02 | Mushuc Runa SCMushuc Runa S | 3 - 1 | 9 de Octubre9 de Octubre |
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| 24 Jul 22 | r03 | Mushuc Runa SCMushuc Runa S | 0 - 0 | Técnico UniversitarioTécnico Unive |
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| 31 Jul 22 | r04 | CumbayáCumbayá | 1 - 1 | Mushuc Runa SCMushuc Runa S |
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| 08 Aug 22 | r05 | Barcelona SCBarcelona SC | 4 - 1 | Mushuc Runa SCMushuc Runa S |
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| 13 Aug 22 | r06 | Mushuc Runa SCMushuc Runa S | 1 - 1 | Orense SCOrense SC |
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| 28 Aug 22 | r08 | Mushuc Runa SCMushuc Runa S | 2 - 0 | GualaceoGualaceo |
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| 04 Sep 22 | r09 | CSD MacaráCSD Macará | 3 - 0 | Mushuc Runa SCMushuc Runa S |
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| 10 Sep 22 | r10 | Mushuc Runa SCMushuc Runa S | 1 - 2 | LDU QuitoLDU Quito |
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| 20 Sep 22 | r11 | Guayaquil City FCGuayaquil Cit | 4 - 1 | Mushuc Runa SCMushuc Runa S |
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| 25 Sep 22 | r07 | Delfin SCDelfin SC | 0 - 0 | Mushuc Runa SCMushuc Runa S |
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| 02 Oct 22 | r12 | Mushuc Runa SCMushuc Runa S | 0 - 0 | EmelecEmelec |
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| 09 Oct 22 | r13 | SD AucasSD Aucas | 0 - 0 | Mushuc Runa SCMushuc Runa S |
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| 17 Oct 22 | r14 | Mushuc Runa SCMushuc Runa S | 0 - 1 | Independiente del ValleIndependiente |
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| 22 Oct 22 | r15 | Deportivo CuencaDeportivo Cue | 3 - 1 | Mushuc Runa SCMushuc Runa S |
Team 2022 Schedules
Aucas
Barcelona SC
Delfín
Deportivo Cuenca
Emelec
Guayaquil City
Independiente del Valle
LDU Quito
Leones
Libertad FC
Macará
Manta
Mushuc Runa
Orense
Técnico Universitario
Universidad Católica del Ecuador
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List
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