| 09 Mar 21 | r01        | Nacional PotosíNacional Poto | 3 - 4 | The StrongestThe Strongest |
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| 13 Mar 21 | r02        | WilstermannWilstermann | 1 - 2 | Nacional PotosíNacional Poto |
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| 29 Mar 21 | r03        | Nacional PotosíNacional Poto | 3 - 2 | Atlético PalmaflorAtlético Palm |
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| 10 Apr 21 | r04        | Always ReadyAlways Ready | 1 - 1 | Nacional PotosíNacional Poto |
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| 24 Apr 21 | r05        | Nacional PotosíNacional Poto | 2 - 1 | Royal PariRoyal Pari |
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| 02 May 21 | r06        | Real PotosiReal Potosi | 1 - 2 | Nacional PotosíNacional Poto |
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| 09 May 21 | r07        | Nacional PotosíNacional Poto | 2 - 1 | Club Deportivo GuabiráClub Deportiv |
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| 13 Jul 21 | r08        | BloomingBlooming | 2 - 1 | Nacional PotosíNacional Poto |
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| 20 Jul 21 | r10        | AuroraAurora | 0 - 0 | Nacional PotosíNacional Poto |
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| 24 Jul 21 | r11        | Nacional PotosíNacional Poto | 0 - 0 | Real TomayapoReal Tomayapo |
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| 30 Jul 21 | r12        | San JoseSan Jose | 0 - 4 | Nacional PotosíNacional Poto |
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| 03 Aug 21 | r13        | Nacional PotosíNacional Poto | 2 - 2 | Real Santa CruzReal Santa Cr |
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| 08 Aug 21 | r14        | Nacional PotosíNacional Poto | 1 - 2 | Independiente PetroleroIndependiente |
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| 12 Aug 21 | r09        | Nacional PotosíNacional Poto | 1 - 1 | BolivarBolivar |
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| 15 Aug 21 | r15        | Oriente PetroleroOriente Petro | 0 - 0 | Nacional PotosíNacional Poto |
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| 18 Aug 21 | r16        | The StrongestThe Strongest | 7 - 0 | Nacional PotosíNacional Poto |
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| 22 Aug 21 | r17        | Nacional PotosíNacional Poto | 0 - 1 | WilstermannWilstermann |
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| 14 Sep 21 | r18        | Atlético PalmaflorAtlético Palm | 0 - 0 | Nacional PotosíNacional Poto |
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| 19 Sep 21 | r19        | Nacional PotosíNacional Poto | 0 - 2 | Always ReadyAlways Ready |
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| 23 Sep 21 | r20        | Royal PariRoyal Pari | 2 - 0 | Nacional PotosíNacional Poto |
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| 26 Sep 21 | r21        | Nacional PotosíNacional Poto | 4 - 2 | Real PotosiReal Potosi |
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| 18 Oct 21 | r22        | Club Deportivo GuabiráClub Deportiv | 3 - 2 | Nacional PotosíNacional Poto |
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| 24 Oct 21 | r23        | Nacional PotosíNacional Poto | 4 - 0 | BloomingBlooming |
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| 28 Oct 21 | r24        | BolivarBolivar | 4 - 2 | Nacional PotosíNacional Poto |
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| 31 Oct 21 | r25        | Nacional PotosíNacional Poto | 0 - 0 | AuroraAurora |
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| 23 Nov 21 | r26        | Real TomayapoReal Tomayapo | 3 - 0 | Nacional PotosíNacional Poto |
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| 26 Nov 21 | r27        | Nacional PotosíNacional Poto | 7 - 1 | San JoseSan Jose |
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| 01 Dec 21 | r28        | Real Santa CruzReal Santa Cr | 1 - 1 | Nacional PotosíNacional Poto |
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| 05 Dec 21 | r29        | Independiente PetroleroIndependiente | 2 - 0 | Nacional PotosíNacional Poto |
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| 10 Dec 21 | r30        | Nacional PotosíNacional Poto | 1 - 0 | Oriente PetroleroOriente Petro |