| 13 Mar 21 | r02  | Club Deportivo GuabiráClub Deportiv | 3 - 1 | BolivarBolivar |
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| 21 Mar 21 | r01 | BloomingBlooming | 0 - 1 | Club Deportivo GuabiráClub Deportiv |
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| 02 Apr 21 | r03 | AuroraAurora | 2 - 1 | Club Deportivo GuabiráClub Deportiv |
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| 11 Apr 21 | r04 | Club Deportivo GuabiráClub Deportiv | 0 - 2 | Real TomayapoReal Tomayapo |
| |
| 24 Apr 21 | r05 | San JoseSan Jose | 0 - 1 | Club Deportivo GuabiráClub Deportiv |
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| 02 May 21 | r06 | Club Deportivo GuabiráClub Deportiv | 1 - 0 | Real Santa CruzReal Santa Cr |
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| 09 May 21 | r07 | Nacional PotosíNacional Poto | 2 - 1 | Club Deportivo GuabiráClub Deportiv |
| |
| 11 Jul 21 | r08 | Club Deportivo GuabiráClub Deportiv | 1 - 1 | Oriente PetroleroOriente Petro |
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| 18 Jul 21 | r09 | The StrongestThe Strongest | 2 - 1 | Club Deportivo GuabiráClub Deportiv |
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| 22 Jul 21 | r10 | Club Deportivo GuabiráClub Deportiv | 3 - 2 | WilstermannWilstermann |
| |
| 25 Jul 21 | r11 | Atlético PalmaflorAtlético Palm | 2 - 1 | Club Deportivo GuabiráClub Deportiv |
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| 01 Aug 21 | r12 | Club Deportivo GuabiráClub Deportiv | 0 - 0 | Always ReadyAlways Ready |
| |
| 05 Aug 21 | r13 | Royal PariRoyal Pari | 1 - 1 | Club Deportivo GuabiráClub Deportiv |
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| 09 Aug 21 | r14  | Club Deportivo GuabiráClub Deportiv | 3 - 0 | Real PotosiReal Potosi |
| |
| 13 Aug 21 | r15 | Independiente PetroleroIndependiente | 2 - 1 | Club Deportivo GuabiráClub Deportiv |
| |
| 18 Aug 21 | r16 | Club Deportivo GuabiráClub Deportiv | 4 - 2 | BloomingBlooming |
| |
| 22 Aug 21 | r17 | BolivarBolivar | 6 - 0 | Club Deportivo GuabiráClub Deportiv |
| |
| 13 Sep 21 | r18 | Club Deportivo GuabiráClub Deportiv | 4 - 0 | AuroraAurora |
| |
| 18 Sep 21 | r19 | Real TomayapoReal Tomayapo | 1 - 1 | Club Deportivo GuabiráClub Deportiv |
| |
| 21 Sep 21 | r20 | Club Deportivo GuabiráClub Deportiv | 4 - 0 | San JoseSan Jose |
| |
| 27 Sep 21 | r21 | Real Santa CruzReal Santa Cr | 3 - 0 | Club Deportivo GuabiráClub Deportiv |
| |
| 18 Oct 21 | r22 | Club Deportivo GuabiráClub Deportiv | 3 - 2 | Nacional PotosíNacional Poto |
| |
| 23 Oct 21 | r23 | Oriente PetroleroOriente Petro | 2 - 0 | Club Deportivo GuabiráClub Deportiv |
| |
| 26 Oct 21 | r24 | Club Deportivo GuabiráClub Deportiv | 0 - 0 | The StrongestThe Strongest |
| |
| 30 Oct 21 | r25 | WilstermannWilstermann | 2 - 1 | Club Deportivo GuabiráClub Deportiv |
| |
| 20 Nov 21 | r26 | Club Deportivo GuabiráClub Deportiv | 2 - 0 | Atlético PalmaflorAtlético Palm |
| |
| 27 Nov 21 | r27 | Always ReadyAlways Ready | 6 - 1 | Club Deportivo GuabiráClub Deportiv |
| |
| 02 Dec 21 | r28 | Club Deportivo GuabiráClub Deportiv | 3 - 2 | Royal PariRoyal Pari |
| |
| 05 Dec 21 | r29 | Real PotosiReal Potosi | 1 - 3 | Club Deportivo GuabiráClub Deportiv |
| |
| 12 Dec 21 | r30 | Club Deportivo GuabiráClub Deportiv | 2 - 3 | Independiente PetroleroIndependiente |
Team 2021-2022 Schedules
ABB
Always Ready
Aurora
Blooming
Bolívar
Guabirá
GV San José
Independiente Petrolero
Nacional Potosí
Oriente Petrolero
Real Oruro
Real Potosí
Real Tomayapo
San Antonio Bulo Bulo
The Strongest
Universitario de Vinto
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