| 12 Mar 22 | r02        | Loudoun UnitedLoudoun Unite | 1 - 0 | Indy ElevenIndy Eleven |
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| 19 Mar 22 | r03        | Tampa Bay RowdiesTampa Bay Row | 2 - 0 | Indy ElevenIndy Eleven |
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| 26 Mar 22 | r05        | Louisville CityLouisville Ci | 1 - 1 | Indy ElevenIndy Eleven |
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| 04 Apr 22 | r06        | Indy ElevenIndy Eleven | 1 - 1 | LA Galaxy IILA Galaxy II |
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| 10 Apr 22 | r08        | Rio Grande ValleyRio Grande Va | 1 - 2 | Indy ElevenIndy Eleven |
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| 17 Apr 22 | r09        | Indy ElevenIndy Eleven | 2 - 1 | Atlanta United IIAtlanta Unite |
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| 24 Apr 22 | r11        | Indy ElevenIndy Eleven | 3 - 1 | Orange County SCOrange County |
| 01 May 22 | r11        | Indy ElevenIndy Eleven | 1 - 0 | Hartford AthleticHartford Athl |
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| 15 May 22 | r15        | Memphis 901Memphis 901 | 2 - 1 | Indy ElevenIndy Eleven |
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| 22 May 22 | r16        | Indy ElevenIndy Eleven | 2 - 0 | New York RB IINew York RB I |
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| 28 May 22 | r17        | Indy ElevenIndy Eleven | 1 - 2 | New Mexico UnitedNew Mexico Un |
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| 04 Jun 22 | r18        | Charleston BatteryCharleston Ba | 3 - 4 | Indy ElevenIndy Eleven |
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| 09 Jun 22 | r19        | Miami FCMiami FC | 1 - 1 | Indy ElevenIndy Eleven |
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| 19 Jun 22 | r22        | Colorado SpringsColorado Spri | 4 - 3 | Indy ElevenIndy Eleven |
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| 26 Jun 22 | r23        | San Diego LoyalSan Diego Loy | 5 - 0 | Indy ElevenIndy Eleven |
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| 03 Jul 22 | r24        | Indy ElevenIndy Eleven | 0 - 1 | Miami FCMiami FC |
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| 07 Jul 22 | r25        | Pittsburgh RiverhoundsPittsburgh Ri | 1 - 0 | Indy ElevenIndy Eleven |
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| 10 Jul 22 | r26        | Indy ElevenIndy Eleven | 0 - 1 | Detroit City FCDetroit City |
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| 16 Jul 22 | r27        | New York RB IINew York RB I | 1 - 0 | Indy ElevenIndy Eleven |
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| 24 Jul 22 | r29        | Indy ElevenIndy Eleven | 1 - 1 | Memphis 901Memphis 901 |
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| 31 Jul 22 | r30        | Indy ElevenIndy Eleven | 1 - 3 | Tampa Bay RowdiesTampa Bay Row |
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| 07 Aug 22 | r31        | Indy ElevenIndy Eleven | 0 - 2 | Pittsburgh RiverhoundsPittsburgh Ri |
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| 13 Aug 22 | r33        | Hartford AthleticHartford Athl | 2 - 1 | Indy ElevenIndy Eleven |
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| 21 Aug 22 | r35        | Tulsa RoughnecksTulsa Roughne | 1 - 0 | Indy ElevenIndy Eleven |
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| 28 Aug 22 | r36        | Indy ElevenIndy Eleven | 1 - 0 | San AntonioSan Antonio |
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| 01 Sep 22 | r20        | Indy ElevenIndy Eleven | 2 - 1 | Louisville CityLouisville Ci |
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| 04 Sep 22 | r38        | Detroit City FCDetroit City | 0 - 0 | Indy ElevenIndy Eleven |
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| 11 Sep 22 | r40        | Indy ElevenIndy Eleven | 4 - 3 | Birmingham LegionBirmingham Le |
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| 18 Sep 22 | r41        | Monterey Bay FCMonterey Bay | 5 - 0 | Indy ElevenIndy Eleven |
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| 25 Sep 22 | r43        | Indy ElevenIndy Eleven | 1 - 0 | Loudoun UnitedLoudoun Unite |
| 29 Sep 22 | r43        | Atlanta United IIAtlanta Unite | 0 - 1 | Indy ElevenIndy Eleven |
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| 02 Oct 22 | r44        | Indy ElevenIndy Eleven | 2 - 4 | Tulsa RoughnecksTulsa Roughne |
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| 09 Oct 22 | r45        | Indy ElevenIndy Eleven | 4 - 1 | Charleston BatteryCharleston Ba |
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| 13 Oct 22 | r46        | Birmingham LegionBirmingham Le | 3 - 1 | Indy ElevenIndy Eleven |