| 06 Aug 22 | r01        | Boston United FCBoston United | 3 - 5 | SouthportSouthport |
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| 13 Aug 22 | r02        | SouthportSouthport | 0 - 3 | Peterborough SportsPeterborough |
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| 16 Aug 22 | r03        | SouthportSouthport | 1 - 0 | Darlington F.C.Darlington F. |
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| 20 Aug 22 | r04        | Alfreton TownAlfreton Town | 4 - 0 | SouthportSouthport |
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| 27 Aug 22 | r05        | SouthportSouthport | 0 - 0 | AFC Telford UnitedAFC Telford U |
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| 29 Aug 22 | r06        | AFC FyldeAFC Fylde | 1 - 0 | SouthportSouthport |
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| 03 Sep 22 | r07        | BanburyBanbury | 3 - 1 | SouthportSouthport |
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| 13 Sep 22 | r09        | Chester CityChester City | 1 - 0 | SouthportSouthport |
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| 24 Sep 22 | r10        | SouthportSouthport | 1 - 0 | LeamingtonLeamington |
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| 01 Oct 22 | r11        | SouthportSouthport | 4 - 1 | Bradford Park AvenueBradford Park |
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| 08 Oct 22 | r12        | Gloucester CityGloucester Ci | 3 - 2 | SouthportSouthport |
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| 15 Oct 22 | r38        | Farsley CelticFarsley Celti | 0 - 3 | SouthportSouthport |
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| 22 Oct 22 | r14        | Kidderminster HarriersKidderminster | 0 - 2 | SouthportSouthport |
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| 25 Oct 22 | r15        | Spennymoor Town FCSpennymoor To | 0 - 1 | SouthportSouthport |
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| 29 Oct 22 | r16        | SouthportSouthport | 1 - 4 | Buxton F.C.Buxton F.C. |
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| 05 Nov 22 | r08        | SouthportSouthport | 2 - 1 | ChorleyChorley |
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| 08 Nov 22 | r18        | SouthportSouthport | 2 - 2 | Brackley TownBrackley Town |
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| 12 Nov 22 | r19        | SouthportSouthport | 4 - 0 | Farsley CelticFarsley Celti |
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| 15 Nov 22 | r13        | SouthportSouthport | 1 - 1 | Kings Lynn TownKings Lynn To |
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| 26 Nov 22 | r20        | Kettering TownKettering Tow | 0 - 0 | SouthportSouthport |
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| 03 Dec 22 | r21        | SouthportSouthport | 1 - 1 | Scarborough AthleticScarborough A |
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| 26 Dec 22 | r25        | CurzonCurzon | 1 - 1 | SouthportSouthport |
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| 02 Jan 23 | r26        | SouthportSouthport | 2 - 1 | CurzonCurzon |
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| 07 Jan 23 | r27        | Peterborough SportsPeterborough | 2 - 1 | SouthportSouthport |
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| 14 Jan 23 | r28        | SouthportSouthport | 1 - 2 | AFC FyldeAFC Fylde |
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| 24 Jan 23 | r22        | Blyth SpartansBlyth Spartan | 1 - 0 | SouthportSouthport |
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| 28 Jan 23 | r30        | AFC Telford UnitedAFC Telford U | 1 - 1 | SouthportSouthport |
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| 31 Jan 23 | r24        | Darlington F.C.Darlington F. | 0 - 0 | SouthportSouthport |
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| 04 Feb 23 | r31        | ChorleyChorley | 1 - 2 | SouthportSouthport |
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| 07 Feb 23 | r17        | HerefordHereford | 2 - 0 | SouthportSouthport |
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| 18 Feb 23 | r33        | Buxton F.C.Buxton F.C. | 1 - 0 | SouthportSouthport |
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| 25 Feb 23 | r35        | SouthportSouthport | 0 - 1 | HerefordHereford |
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| 04 Mar 23 | r36        | Brackley TownBrackley Town | 1 - 0 | SouthportSouthport |
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| 07 Mar 23 | r37        | SouthportSouthport | 2 - 1 | Blyth SpartansBlyth Spartan |
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| 14 Mar 23 | r23        | SouthportSouthport | 1 - 1 | Boston United FCBoston United |
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| 18 Mar 23 | r39        | SouthportSouthport | 0 - 0 | Kettering TownKettering Tow |
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| 21 Mar 23 | r29        | SouthportSouthport | 0 - 0 | Alfreton TownAlfreton Town |
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| 25 Mar 23 | r40        | Scarborough AthleticScarborough A | 0 - 1 | SouthportSouthport |
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| 01 Apr 23 | r41        | SouthportSouthport | 0 - 1 | Gloucester CityGloucester Ci |
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| 04 Apr 23 | r32        | SouthportSouthport | 1 - 2 | BanburyBanbury |
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| 07 Apr 23 | r42        | Bradford Park AvenueBradford Park | 2 - 0 | SouthportSouthport |
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| 10 Apr 23 | r43        | SouthportSouthport | 1 - 2 | Chester CityChester City |
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| 15 Apr 23 | r44        | Kings Lynn TownKings Lynn To | 3 - 2 | SouthportSouthport |
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| 18 Apr 23 | r34        | SouthportSouthport | 1 - 3 | Spennymoor Town FCSpennymoor To |
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| 22 Apr 23 | r45        | SouthportSouthport | 1 - 3 | Kidderminster HarriersKidderminster |
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| 29 Apr 23 | r46        | LeamingtonLeamington | 2 - 1 | SouthportSouthport |