| 25 Jul 21 | r01  | Podillya KhmelnytskyiPodillya Khme | 0 - 0 | Obolon-BrovarObolon-Brovar |
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| 02 Aug 21 | r02 | VolynVolyn | 1 - 0 | Podillya KhmelnytskyiPodillya Khme |
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| 08 Aug 21 | r03 | Podillya KhmelnytskyiPodillya Khme | 3 - 0 | VPK-Ahro ShevchenkivkaVPK-Ahro Shev |
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| 13 Aug 21 | r04 | AvanhardAvanhard | 2 - 1 | Podillya KhmelnytskyiPodillya Khme |
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| 23 Aug 21 | r05 | Podillya KhmelnytskyiPodillya Khme | 1 - 0 | Polissya ZhytomyrPolissya Zhyt |
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| 27 Aug 21 | r06 | Kryvbas Kryvyi RihKryvbas Kryvy | 3 - 2 | Podillya KhmelnytskyiPodillya Khme |
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| 04 Sep 21 | r07 | Podillya KhmelnytskyiPodillya Khme | 1 - 1 | Nyva TernopilNyva Ternopil |
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| 12 Sep 21 | r08 | Hirnyk-SportHirnyk-Sport | 0 - 0 | Podillya KhmelnytskyiPodillya Khme |
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| 19 Sep 21 | r09 | Podillya KhmelnytskyiPodillya Khme | 4 - 1 | KreminKremin |
| 19 Sep 21 | r09 | Podillya KhmelnytskyiPodillya Khme | 4 - 1 | MykolaivMykolaiv |
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| 25 Sep 21 | r10 | AhrobiznesAhrobiznes | 0 - 0 | Podillya KhmelnytskyiPodillya Khme |
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| 01 Oct 21 | r11 | Podillya KhmelnytskyiPodillya Khme | 0 - 0 | Olimpik DonetskOlimpik Donet |
| 01 Oct 21 | r11 | Podillya KhmelnytskyiPodillya Khme | 0 - 1 | MynaiMynai |
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| 07 Oct 21 | r12 | Podillya KhmelnytskyiPodillya Khme | 0 - 0 | Alians Lypova DolynaAlians Lypova |
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| 12 Oct 21 | r13 | UzhhorodUzhhorod | 0 - 1 | Podillya KhmelnytskyiPodillya Khme |
| 12 Oct 21 | r13 | UzhhorodUzhhorod | 0 - 1 | Podillya KhmelnytskyiPodillya Khme |
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| 16 Oct 21 | r14 | Podillya KhmelnytskyiPodillya Khme | 0 - 2 | PrykarpattiaPrykarpattia |
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| 24 Oct 21 | r15 | Metalist KharkivMetalist Khar | 3 - 0 | Podillya KhmelnytskyiPodillya Khme |
| 24 Oct 21 | r15 | Metalist KharkivMetalist Khar | 3 - 0 | Podillya KhmelnytskyiPodillya Khme |
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| 31 Oct 21 | r16 | Obolon-BrovarObolon-Brovar | 1 - 0 | Podillya KhmelnytskyiPodillya Khme |
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| 08 Nov 21 | r17 | Podillya KhmelnytskyiPodillya Khme | 2 - 0 | VolynVolyn |
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| 13 Nov 21 | r18 | VPK-Ahro ShevchenkivkaVPK-Ahro Shev | 1 - 0 | Podillya KhmelnytskyiPodillya Khme |
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| 20 Nov 21 | r19 | Podillya KhmelnytskyiPodillya Khme | 2 - 1 | AvanhardAvanhard |
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| 27 Nov 21 | r20 | Polissya ZhytomyrPolissya Zhyt | 1 - 2 | Podillya KhmelnytskyiPodillya Khme |
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| 19 Mar 22 | r21 | Podillya KhmelnytskyiPodillya Khme | - | Kryvbas Kryvyi RihKryvbas Kryvy |
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| 26 Mar 22 | r22 | Nyva TernopilNyva Ternopil | - | Podillya KhmelnytskyiPodillya Khme |
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| 02 Apr 22 | r23 | Podillya KhmelnytskyiPodillya Khme | - | Hirnyk-SportHirnyk-Sport |
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| 09 Apr 22 | r24 | MykolaivMykolaiv | - | Podillya KhmelnytskyiPodillya Khme |
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| 16 Apr 22 | r25 | Podillya KhmelnytskyiPodillya Khme | - | AhrobiznesAhrobiznes |
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| 23 Apr 22 | r26 | MynaiMynai | - | Podillya KhmelnytskyiPodillya Khme |
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| 30 Apr 22 | r27 | Alians Lypova DolynaAlians Lypova | - | Podillya KhmelnytskyiPodillya Khme |
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| 07 May 22 | r28 | Podillya KhmelnytskyiPodillya Khme | - | UzhhorodUzhhorod |
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| 14 May 22 | r29 | PrykarpattiaPrykarpattia | - | Podillya KhmelnytskyiPodillya Khme |
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| 21 May 22 | r30 | Podillya KhmelnytskyiPodillya Khme | - | Metalist KharkivMetalist Khar |
Team 2021-2022 Schedules
Ahrobiznes Volochysk
Bukovyna Chernivtsi
Chernihiv
Chornomorets Odesa
FSC Mariupol
Inhulets Petrove
Livyi Bereh Kyiv
Metalist Kharkiv
Metalurh Zaporizhzhia
Nyva Ternopil
Podillya Khmelnytskyi
Probiy Horodenka
Prykarpattia Ivano-Frankivsk
UCSA Tarasivka
Viktoriya Sumy
Vorskla Poltava
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