| 24 Jul 21 | r01    | MFK RužomberokMFK Ružombero | 0 - 0 | FK Senica FK Senica |
| |
| 30 Jul 21 | r02 | ŠKF SereďŠKF Sereď | 2 - 3 | MFK RužomberokMFK Ružombero |
| |
| 13 Aug 21 | r04  | TrencinTrencin | 1 - 1 | MFK RužomberokMFK Ružombero |
| |
| 21 Aug 21 | r05 | MFK RužomberokMFK Ružombero | 0 - 0 | FC Spartak TrnavaFC Spartak Tr |
| |
| 28 Aug 21 | r06 | MFK RužomberokMFK Ružombero | 0 - 0 | MFK Zemplín MichalovceMFK Zemplín M |
| |
| 10 Sep 21 | r07 | ViOn Zlaté MoravceViOn Zlaté Mo | 2 - 2 | MFK RužomberokMFK Ružombero |
| |
| 18 Sep 21 | r08 | MFK RužomberokMFK Ružombero | 1 - 2 | DAC 1904 Dunajská StredaDAC 1904 Duna |
| |
| 22 Sep 21 | r03 | MFK RužomberokMFK Ružombero | 1 - 0 | Slovan BratislavaSlovan Bratis |
| |
| 25 Sep 21 | r09 | MSK ZilinaMSK Zilina | 0 - 2 | MFK RužomberokMFK Ružombero |
| |
| 02 Oct 21 | r10 | MFK RužomberokMFK Ružombero | 4 - 1 | Tatran Liptovský MikulášTatran Liptov |
| |
| 16 Oct 21 | r11 | FK PohronieFK Pohronie | 2 - 2 | MFK RužomberokMFK Ružombero |
| |
| 23 Oct 21 | r12 | FK Senica FK Senica | 0 - 2 | MFK RužomberokMFK Ružombero |
| |
| 30 Oct 21 | r13 | MFK RužomberokMFK Ružombero | 3 - 1 | ŠKF SereďŠKF Sereď |
| |
| 07 Nov 21 | r14 | Slovan BratislavaSlovan Bratis | 1 - 0 | MFK RužomberokMFK Ružombero |
| |
| 19 Nov 21 | r15 | MFK RužomberokMFK Ružombero | 3 - 0 | TrencinTrencin |
| |
| 28 Nov 21 | r16 | FC Spartak TrnavaFC Spartak Tr | 0 - 3 | MFK RužomberokMFK Ružombero |
| |
| 04 Dec 21 | r17 | MFK Zemplín MichalovceMFK Zemplín M | 0 - 3 | MFK RužomberokMFK Ružombero |
| |
| 11 Dec 21 | r18 | MFK RužomberokMFK Ružombero | 1 - 1 | ViOn Zlaté MoravceViOn Zlaté Mo |
| |
| 17 Dec 21 | r19 | DAC 1904 Dunajská StredaDAC 1904 Duna | 0 - 0 | MFK RužomberokMFK Ružombero |
| |
| 14 Feb 22 | r20 | MFK RužomberokMFK Ružombero | 5 - 1 | MSK ZilinaMSK Zilina |
| |
| 19 Feb 22 | r21 | Tatran Liptovský MikulášTatran Liptov | 3 - 2 | MFK RužomberokMFK Ružombero |
| |
| 26 Feb 22 | r22 | MFK RužomberokMFK Ružombero | 1 - 0 | FK PohronieFK Pohronie |
| |
| 04 Mar 22 | r01 | MFK RužomberokMFK Ružombero | 4 - 1 | DAC 1904 Dunajská StredaDAC 1904 Duna |
| |
| 12 Mar 22 | r02 | Slovan BratislavaSlovan Bratis | 1 - 1 | MFK RužomberokMFK Ružombero |
| |
| 20 Mar 22 | r03 | MFK RužomberokMFK Ružombero | 0 - 0 | FC Spartak TrnavaFC Spartak Tr |
| |
| 01 Apr 22 | r04 | MSK ZilinaMSK Zilina | 0 - 2 | MFK RužomberokMFK Ružombero |
| |
| 10 Apr 22 | r05 | ŠKF SereďŠKF Sereď | 1 - 3 | MFK RužomberokMFK Ružombero |
| |
| 15 Apr 22 | r06 | MFK RužomberokMFK Ružombero | 0 - 0 | Slovan BratislavaSlovan Bratis |
| |
| 24 Apr 22 | r07 | FC Spartak TrnavaFC Spartak Tr | 0 - 0 | MFK RužomberokMFK Ružombero |
| |
| 04 May 22 | r08 | MFK RužomberokMFK Ružombero | 3 - 0 | MSK ZilinaMSK Zilina |
| |
| 15 May 22 | r09 | DAC 1904 Dunajská StredaDAC 1904 Duna | 2 - 3 | MFK RužomberokMFK Ružombero |
| |
| 21 May 22 | r10 | MFK RužomberokMFK Ružombero | 3 - 1 | ŠKF SereďŠKF Sereď |
Team 2021-2022 Schedules
DAC 1904 Dunajská Streda
Komárno
Košice
MSK Zilina
Ružomberok
Skalica
Slovan Bratislava
Spartak Trnava
Tatran Prešov
Trenčín
Železiarne Podbrezová
Zemplín Michalovce
League Table
List
Poster
= Banner Image 
= Fanart Image