| 24 Jul 21 | r01    | Tatran Liptovský MikulášTatran Liptov | 1 - 4 | Slovan BratislavaSlovan Bratis |
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| 31 Jul 21 | r02 | Slovan BratislavaSlovan Bratis | 2 - 0 | TrencinTrencin |
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| 14 Aug 21 | r04 | Slovan BratislavaSlovan Bratis | 3 - 1 | MFK Zemplín MichalovceMFK Zemplín M |
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| 22 Aug 21 | r05 | ŠKF SereďŠKF Sereď | 0 - 1 | Slovan BratislavaSlovan Bratis |
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| 29 Aug 21 | r06 | Slovan BratislavaSlovan Bratis | 4 - 1 | ViOn Zlaté MoravceViOn Zlaté Mo |
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| 12 Sep 21 | r07 | DAC 1904 Dunajská StredaDAC 1904 Duna | 1 - 1 | Slovan BratislavaSlovan Bratis |
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| 19 Sep 21 | r08 | Slovan BratislavaSlovan Bratis | 2 - 2 | MSK ZilinaMSK Zilina |
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| 22 Sep 21 | r03  | MFK RužomberokMFK Ružombero | 1 - 0 | Slovan BratislavaSlovan Bratis |
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| 25 Sep 21 | r09 | FK Senica FK Senica | 0 - 3 | Slovan BratislavaSlovan Bratis |
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| 03 Oct 21 | r10 | Slovan BratislavaSlovan Bratis | 5 - 1 | FK PohronieFK Pohronie |
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| 17 Oct 21 | r11 | FC Spartak TrnavaFC Spartak Tr | 0 - 3 | Slovan BratislavaSlovan Bratis |
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| 24 Oct 21 | r12 | Slovan BratislavaSlovan Bratis | 4 - 0 | Tatran Liptovský MikulášTatran Liptov |
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| 31 Oct 21 | r13 | TrencinTrencin | 2 - 3 | Slovan BratislavaSlovan Bratis |
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| 07 Nov 21 | r14 | Slovan BratislavaSlovan Bratis | 1 - 0 | MFK RužomberokMFK Ružombero |
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| 21 Nov 21 | r15 | MFK Zemplín MichalovceMFK Zemplín M | 1 - 2 | Slovan BratislavaSlovan Bratis |
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| 29 Nov 21 | r16 | Slovan BratislavaSlovan Bratis | 2 - 0 | ŠKF SereďŠKF Sereď |
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| 03 Dec 21 | r17 | ViOn Zlaté MoravceViOn Zlaté Mo | 1 - 2 | Slovan BratislavaSlovan Bratis |
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| 12 Dec 21 | r18 | Slovan BratislavaSlovan Bratis | 0 - 0 | DAC 1904 Dunajská StredaDAC 1904 Duna |
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| 19 Dec 21 | r19 | MSK ZilinaMSK Zilina | 1 - 1 | Slovan BratislavaSlovan Bratis |
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| 12 Feb 22 | r20 | Slovan BratislavaSlovan Bratis | 5 - 0 | FK Senica FK Senica |
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| 19 Feb 22 | r21 | FK PohronieFK Pohronie | 3 - 4 | Slovan BratislavaSlovan Bratis |
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| 26 Feb 22 | r22 | Slovan BratislavaSlovan Bratis | 0 - 0 | FC Spartak TrnavaFC Spartak Tr |
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| 06 Mar 22 | r01 | MSK ZilinaMSK Zilina | 2 - 3 | Slovan BratislavaSlovan Bratis |
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| 12 Mar 22 | r02 | Slovan BratislavaSlovan Bratis | 1 - 1 | MFK RužomberokMFK Ružombero |
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| 19 Mar 22 | r03 | Slovan BratislavaSlovan Bratis | 5 - 1 | ŠKF SereďŠKF Sereď |
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| 03 Apr 22 | r04 | FC Spartak TrnavaFC Spartak Tr | 0 - 1 | Slovan BratislavaSlovan Bratis |
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| 10 Apr 22 | r05 | Slovan BratislavaSlovan Bratis | 3 - 1 | DAC 1904 Dunajská StredaDAC 1904 Duna |
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| 15 Apr 22 | r06 | MFK RužomberokMFK Ružombero | 0 - 0 | Slovan BratislavaSlovan Bratis |
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| 24 Apr 22 | r07 | DAC 1904 Dunajská StredaDAC 1904 Duna | 2 - 0 | Slovan BratislavaSlovan Bratis |
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| 01 May 22 | r08 | Slovan BratislavaSlovan Bratis | 1 - 0 | FC Spartak TrnavaFC Spartak Tr |
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| 14 May 22 | r09 | ŠKF SereďŠKF Sereď | 0 - 3 | Slovan BratislavaSlovan Bratis |
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| 21 May 22 | r10 | Slovan BratislavaSlovan Bratis | 2 - 2 | MSK ZilinaMSK Zilina |
Team 2021-2022 Schedules
DAC 1904 Dunajská Streda
Komárno
Košice
MSK Zilina
Ružomberok
Skalica
Slovan Bratislava
Spartak Trnava
Tatran Prešov
Trenčín
Železiarne Podbrezová
Zemplín Michalovce
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List
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