| 23 Jul 21 | r01    | TrencinTrencin | 4 - 0 | ViOn Zlaté MoravceViOn Zlaté Mo |
| 24 Jul 21 | r01 | MFK RužomberokMFK Ružombero | 0 - 0 | FK Senica FK Senica |
| 24 Jul 21 | r01 | Tatran Liptovský MikulášTatran Liptov | 1 - 4 | Slovan BratislavaSlovan Bratis |
| 25 Jul 21 | r01 | MFK Zemplín MichalovceMFK Zemplín M | 4 - 1 | DAC 1904 Dunajská StredaDAC 1904 Duna |
| 25 Jul 21 | r01 | MSK ZilinaMSK Zilina | 3 - 0 | ŠKF SereďŠKF Sereď |
| 25 Jul 21 | r01 | FC Spartak TrnavaFC Spartak Tr | 2 - 0 | FK PohronieFK Pohronie |
| |
| 30 Jul 21 | r02 | ŠKF SereďŠKF Sereď | 2 - 3 | MFK RužomberokMFK Ružombero |
| 31 Jul 21 | r02 | FK PohronieFK Pohronie | 2 - 0 | MFK Zemplín MichalovceMFK Zemplín M |
| 31 Jul 21 | r02 | Slovan BratislavaSlovan Bratis | 2 - 0 | TrencinTrencin |
| 01 Aug 21 | r02 | FK Senica FK Senica | 2 - 1 | FC Spartak TrnavaFC Spartak Tr |
| 01 Aug 21 | r02 | ViOn Zlaté MoravceViOn Zlaté Mo | 0 - 1 | MSK ZilinaMSK Zilina |
| 01 Aug 21 | r02 | DAC 1904 Dunajská StredaDAC 1904 Duna | 3 - 1 | Tatran Liptovský MikulášTatran Liptov |
| |
| 06 Aug 21 | r03 | ViOn Zlaté MoravceViOn Zlaté Mo | 1 - 1 | FK Senica FK Senica |
| 07 Aug 21 | r03 | MFK Zemplín MichalovceMFK Zemplín M | 1 - 2 | TrencinTrencin |
| 08 Aug 21 | r03 | MSK ZilinaMSK Zilina | 3 - 1 | FK PohronieFK Pohronie |
| 08 Aug 21 | r03 | ŠKF SereďŠKF Sereď | 1 - 0 | DAC 1904 Dunajská StredaDAC 1904 Duna |
| 09 Aug 21 | r03 | FC Spartak TrnavaFC Spartak Tr | 4 - 0 | Tatran Liptovský MikulášTatran Liptov |
| |
| 13 Aug 21 | r04  | TrencinTrencin | 1 - 1 | MFK RužomberokMFK Ružombero |
| 14 Aug 21 | r04 | Slovan BratislavaSlovan Bratis | 3 - 1 | MFK Zemplín MichalovceMFK Zemplín M |
| 14 Aug 21 | r04 | FK Senica FK Senica | 1 - 1 | DAC 1904 Dunajská StredaDAC 1904 Duna |
| 14 Aug 21 | r04 | FK PohronieFK Pohronie | 1 - 1 | ŠKF SereďŠKF Sereď |
| 15 Aug 21 | r04 | FC Spartak TrnavaFC Spartak Tr | 2 - 0 | ViOn Zlaté MoravceViOn Zlaté Mo |
| 15 Aug 21 | r04 | Tatran Liptovský MikulášTatran Liptov | 2 - 1 | MSK ZilinaMSK Zilina |
| |
| 20 Aug 21 | r05 | ViOn Zlaté MoravceViOn Zlaté Mo | 1 - 0 | FK PohronieFK Pohronie |
| 21 Aug 21 | r05 | MFK RužomberokMFK Ružombero | 0 - 0 | FC Spartak TrnavaFC Spartak Tr |
| 21 Aug 21 | r05 | MFK Zemplín MichalovceMFK Zemplín M | 2 - 1 | Tatran Liptovský MikulášTatran Liptov |
| 22 Aug 21 | r05 | MSK ZilinaMSK Zilina | 3 - 0 | FK Senica FK Senica |
| 22 Aug 21 | r05 | ŠKF SereďŠKF Sereď | 0 - 1 | Slovan BratislavaSlovan Bratis |
| 22 Aug 21 | r05 | DAC 1904 Dunajská StredaDAC 1904 Duna | 1 - 1 | TrencinTrencin |
| |
| 27 Aug 21 | r06 | FK PohronieFK Pohronie | 0 - 3 | DAC 1904 Dunajská StredaDAC 1904 Duna |
| 28 Aug 21 | r06 | MFK RužomberokMFK Ružombero | 0 - 0 | MFK Zemplín MichalovceMFK Zemplín M |
| 28 Aug 21 | r06 | TrencinTrencin | 0 - 0 | ŠKF SereďŠKF Sereď |
| 28 Aug 21 | r06 | Tatran Liptovský MikulášTatran Liptov | 1 - 2 | FK Senica FK Senica |
| 29 Aug 21 | r06 | Slovan BratislavaSlovan Bratis | 4 - 1 | ViOn Zlaté MoravceViOn Zlaté Mo |
| 29 Aug 21 | r06 | FC Spartak TrnavaFC Spartak Tr | 1 - 1 | MSK ZilinaMSK Zilina |
| |
| 10 Sep 21 | r07 | ViOn Zlaté MoravceViOn Zlaté Mo | 2 - 2 | MFK RužomberokMFK Ružombero |
| 11 Sep 21 | r07 | MSK ZilinaMSK Zilina | 1 - 3 | TrencinTrencin |
| 11 Sep 21 | r07 | MFK Zemplín MichalovceMFK Zemplín M | 1 - 2 | FC Spartak TrnavaFC Spartak Tr |
| 11 Sep 21 | r07 | FK Senica FK Senica | 1 - 0 | FK PohronieFK Pohronie |
| 11 Sep 21 | r07 | ŠKF SereďŠKF Sereď | 2 - 0 | Tatran Liptovský MikulášTatran Liptov |
| 12 Sep 21 | r07 | DAC 1904 Dunajská StredaDAC 1904 Duna | 1 - 1 | Slovan BratislavaSlovan Bratis |
| |
| 17 Sep 21 | r08 | FC Spartak TrnavaFC Spartak Tr | 2 - 0 | ŠKF SereďŠKF Sereď |
| 18 Sep 21 | r08 | TrencinTrencin | 3 - 3 | FK Senica FK Senica |
| 18 Sep 21 | r08 | MFK RužomberokMFK Ružombero | 1 - 2 | DAC 1904 Dunajská StredaDAC 1904 Duna |
| 18 Sep 21 | r08 | MFK Zemplín MichalovceMFK Zemplín M | 2 - 1 | ViOn Zlaté MoravceViOn Zlaté Mo |
| 18 Sep 21 | r08 | Tatran Liptovský MikulášTatran Liptov | 5 - 1 | FK PohronieFK Pohronie |
| 19 Sep 21 | r08 | Slovan BratislavaSlovan Bratis | 2 - 2 | MSK ZilinaMSK Zilina |
| |
| 22 Sep 21 | r03 | MFK RužomberokMFK Ružombero | 1 - 0 | Slovan BratislavaSlovan Bratis |
| |
| 24 Sep 21 | r09 | FK PohronieFK Pohronie | 2 - 2 | TrencinTrencin |
| 25 Sep 21 | r09 | MSK ZilinaMSK Zilina | 0 - 2 | MFK RužomberokMFK Ružombero |
| 25 Sep 21 | r09 | FK Senica FK Senica | 0 - 3 | Slovan BratislavaSlovan Bratis |
| 25 Sep 21 | r09 | ŠKF SereďŠKF Sereď | 0 - 1 | MFK Zemplín MichalovceMFK Zemplín M |
| 25 Sep 21 | r09 | ViOn Zlaté MoravceViOn Zlaté Mo | 2 - 2 | Tatran Liptovský MikulášTatran Liptov |
| 26 Sep 21 | r09 | DAC 1904 Dunajská StredaDAC 1904 Duna | 0 - 3 | FC Spartak TrnavaFC Spartak Tr |
| |
| 01 Oct 21 | r10 | DAC 1904 Dunajská StredaDAC 1904 Duna | 4 - 2 | ViOn Zlaté MoravceViOn Zlaté Mo |
| 02 Oct 21 | r10 | MFK Zemplín MichalovceMFK Zemplín M | 1 - 0 | MSK ZilinaMSK Zilina |
| 02 Oct 21 | r10 | ŠKF SereďŠKF Sereď | 2 - 1 | FK Senica FK Senica |
| 02 Oct 21 | r10 | MFK RužomberokMFK Ružombero | 4 - 1 | Tatran Liptovský MikulášTatran Liptov |
| 03 Oct 21 | r10 | Slovan BratislavaSlovan Bratis | 5 - 1 | FK PohronieFK Pohronie |
| 03 Oct 21 | r10 | TrencinTrencin | 0 - 1 | FC Spartak TrnavaFC Spartak Tr |
| |
| 15 Oct 21 | r11 | Tatran Liptovský MikulášTatran Liptov | 2 - 1 | TrencinTrencin |
| 16 Oct 21 | r11 | MSK ZilinaMSK Zilina | 0 - 2 | DAC 1904 Dunajská StredaDAC 1904 Duna |
| 16 Oct 21 | r11 | ViOn Zlaté MoravceViOn Zlaté Mo | 2 - 2 | ŠKF SereďŠKF Sereď |
| 16 Oct 21 | r11 | FK PohronieFK Pohronie | 2 - 2 | MFK RužomberokMFK Ružombero |
| 16 Oct 21 | r11 | FK Senica FK Senica | 1 - 1 | MFK Zemplín MichalovceMFK Zemplín M |
| 17 Oct 21 | r11 | FC Spartak TrnavaFC Spartak Tr | 0 - 3 | Slovan BratislavaSlovan Bratis |
| |
| 22 Oct 21 | r12 | ŠKF SereďŠKF Sereď | 1 - 1 | MSK ZilinaMSK Zilina |
| 23 Oct 21 | r12 | ViOn Zlaté MoravceViOn Zlaté Mo | 0 - 1 | TrencinTrencin |
| 23 Oct 21 | r12 | FK Senica FK Senica | 0 - 2 | MFK RužomberokMFK Ružombero |
| 23 Oct 21 | r12 | FK PohronieFK Pohronie | 0 - 2 | FC Spartak TrnavaFC Spartak Tr |
| 24 Oct 21 | r12 | Slovan BratislavaSlovan Bratis | 4 - 0 | Tatran Liptovský MikulášTatran Liptov |
| 24 Oct 21 | r12 | DAC 1904 Dunajská StredaDAC 1904 Duna | 1 - 0 | MFK Zemplín MichalovceMFK Zemplín M |
| |
| 29 Oct 21 | r13 | FC Spartak TrnavaFC Spartak Tr | 2 - 1 | FK Senica FK Senica |
| 30 Oct 21 | r13 | MFK RužomberokMFK Ružombero | 3 - 1 | ŠKF SereďŠKF Sereď |
| 30 Oct 21 | r13 | MSK ZilinaMSK Zilina | 4 - 1 | ViOn Zlaté MoravceViOn Zlaté Mo |
| 30 Oct 21 | r13 | MFK Zemplín MichalovceMFK Zemplín M | 0 - 2 | FK PohronieFK Pohronie |
| 30 Oct 21 | r13 | Tatran Liptovský MikulášTatran Liptov | 1 - 0 | DAC 1904 Dunajská StredaDAC 1904 Duna |
| 31 Oct 21 | r13 | TrencinTrencin | 2 - 3 | Slovan BratislavaSlovan Bratis |
| |
| 05 Nov 21 | r14 | TrencinTrencin | 4 - 2 | MFK Zemplín MichalovceMFK Zemplín M |
| 06 Nov 21 | r14 | FK Senica FK Senica | 1 - 2 | ViOn Zlaté MoravceViOn Zlaté Mo |
| 06 Nov 21 | r14 | FK PohronieFK Pohronie | 1 - 2 | MSK ZilinaMSK Zilina |
| 06 Nov 21 | r14 | DAC 1904 Dunajská StredaDAC 1904 Duna | 1 - 3 | ŠKF SereďŠKF Sereď |
| 07 Nov 21 | r14 | Slovan BratislavaSlovan Bratis | 1 - 0 | MFK RužomberokMFK Ružombero |
| 07 Nov 21 | r14 | Tatran Liptovský MikulášTatran Liptov | 0 - 2 | FC Spartak TrnavaFC Spartak Tr |
| |
| 19 Nov 21 | r15 | MFK RužomberokMFK Ružombero | 3 - 0 | TrencinTrencin |
| 20 Nov 21 | r15 | DAC 1904 Dunajská StredaDAC 1904 Duna | 1 - 0 | FK Senica FK Senica |
| 20 Nov 21 | r15 | ViOn Zlaté MoravceViOn Zlaté Mo | 0 - 0 | FC Spartak TrnavaFC Spartak Tr |
| 20 Nov 21 | r15 | ŠKF SereďŠKF Sereď | 3 - 1 | FK PohronieFK Pohronie |
| 20 Nov 21 | r15 | MSK ZilinaMSK Zilina | 2 - 2 | Tatran Liptovský MikulášTatran Liptov |
| 21 Nov 21 | r15 | MFK Zemplín MichalovceMFK Zemplín M | 1 - 2 | Slovan BratislavaSlovan Bratis |
| |
| 27 Nov 21 | r16 | TrencinTrencin | 0 - 1 | DAC 1904 Dunajská StredaDAC 1904 Duna |
| 27 Nov 21 | r16 | FK PohronieFK Pohronie | 0 - 2 | ViOn Zlaté MoravceViOn Zlaté Mo |
| 27 Nov 21 | r16 | Tatran Liptovský MikulášTatran Liptov | 0 - 1 | MFK Zemplín MichalovceMFK Zemplín M |
| 28 Nov 21 | r16 | FC Spartak TrnavaFC Spartak Tr | 0 - 3 | MFK RužomberokMFK Ružombero |
| 29 Nov 21 | r16 | Slovan BratislavaSlovan Bratis | 2 - 0 | ŠKF SereďŠKF Sereď |
| 30 Nov 21 | r16 | FK Senica FK Senica | 2 - 2 | MSK ZilinaMSK Zilina |
| |
| 03 Dec 21 | r17 | ViOn Zlaté MoravceViOn Zlaté Mo | 1 - 2 | Slovan BratislavaSlovan Bratis |
| 04 Dec 21 | r17 | MFK Zemplín MichalovceMFK Zemplín M | 0 - 3 | MFK RužomberokMFK Ružombero |
| 04 Dec 21 | r17 | DAC 1904 Dunajská StredaDAC 1904 Duna | 2 - 0 | FK PohronieFK Pohronie |
| 04 Dec 21 | r17 | ŠKF SereďŠKF Sereď | 4 - 2 | TrencinTrencin |
| 04 Dec 21 | r17 | FK Senica FK Senica | 1 - 0 | Tatran Liptovský MikulášTatran Liptov |
| 05 Dec 21 | r17 | MSK ZilinaMSK Zilina | 0 - 1 | FC Spartak TrnavaFC Spartak Tr |
| |
| 10 Dec 21 | r18 | FC Spartak TrnavaFC Spartak Tr | 2 - 0 | MFK Zemplín MichalovceMFK Zemplín M |
| 11 Dec 21 | r18 | MFK RužomberokMFK Ružombero | 1 - 1 | ViOn Zlaté MoravceViOn Zlaté Mo |
| 11 Dec 21 | r18 | TrencinTrencin | 1 - 3 | MSK ZilinaMSK Zilina |
| 11 Dec 21 | r18 | FK PohronieFK Pohronie | 0 - 1 | FK Senica FK Senica |
| 11 Dec 21 | r18 | Tatran Liptovský MikulášTatran Liptov | 1 - 1 | ŠKF SereďŠKF Sereď |
| 12 Dec 21 | r18 | Slovan BratislavaSlovan Bratis | 0 - 0 | DAC 1904 Dunajská StredaDAC 1904 Duna |
| |
| 17 Dec 21 | r19 | DAC 1904 Dunajská StredaDAC 1904 Duna | 0 - 0 | MFK RužomberokMFK Ružombero |
| 18 Dec 21 | r19 | FK Senica FK Senica | 1 - 0 | TrencinTrencin |
| 18 Dec 21 | r19 | ViOn Zlaté MoravceViOn Zlaté Mo | 0 - 1 | MFK Zemplín MichalovceMFK Zemplín M |
| 18 Dec 21 | r19 | ŠKF SereďŠKF Sereď | 0 - 1 | FC Spartak TrnavaFC Spartak Tr |
| 18 Dec 21 | r19 | FK PohronieFK Pohronie | 2 - 2 | Tatran Liptovský MikulášTatran Liptov |
| 19 Dec 21 | r19 | MSK ZilinaMSK Zilina | 1 - 1 | Slovan BratislavaSlovan Bratis |
| |
| 11 Feb 22 | r20 | MFK Zemplín MichalovceMFK Zemplín M | 0 - 1 | ŠKF SereďŠKF Sereď |
| 12 Feb 22 | r20 | Slovan BratislavaSlovan Bratis | 5 - 0 | FK Senica FK Senica |
| 12 Feb 22 | r20 | TrencinTrencin | 3 - 0 | FK PohronieFK Pohronie |
| 12 Feb 22 | r20 | Tatran Liptovský MikulášTatran Liptov | 0 - 0 | ViOn Zlaté MoravceViOn Zlaté Mo |
| 13 Feb 22 | r20 | FC Spartak TrnavaFC Spartak Tr | 1 - 1 | DAC 1904 Dunajská StredaDAC 1904 Duna |
| 14 Feb 22 | r20 | MFK RužomberokMFK Ružombero | 5 - 1 | MSK ZilinaMSK Zilina |
| |
| 18 Feb 22 | r21 | ViOn Zlaté MoravceViOn Zlaté Mo | 2 - 0 | DAC 1904 Dunajská StredaDAC 1904 Duna |
| 19 Feb 22 | r21 | MSK ZilinaMSK Zilina | 2 - 1 | MFK Zemplín MichalovceMFK Zemplín M |
| 19 Feb 22 | r21 | FK PohronieFK Pohronie | 3 - 4 | Slovan BratislavaSlovan Bratis |
| 19 Feb 22 | r21 | FC Spartak TrnavaFC Spartak Tr | 0 - 0 | TrencinTrencin |
| 19 Feb 22 | r21 | Tatran Liptovský MikulášTatran Liptov | 3 - 2 | MFK RužomberokMFK Ružombero |
| 20 Feb 22 | r21 | FK Senica FK Senica | 1 - 2 | ŠKF SereďŠKF Sereď |
| |
| 26 Feb 22 | r22 | ŠKF SereďŠKF Sereď | 2 - 1 | ViOn Zlaté MoravceViOn Zlaté Mo |
| 26 Feb 22 | r22 | Slovan BratislavaSlovan Bratis | 0 - 0 | FC Spartak TrnavaFC Spartak Tr |
| 26 Feb 22 | r22 | MFK RužomberokMFK Ružombero | 1 - 0 | FK PohronieFK Pohronie |
| 26 Feb 22 | r22 | MFK Zemplín MichalovceMFK Zemplín M | 0 - 1 | FK Senica FK Senica |
| 26 Feb 22 | r22 | DAC 1904 Dunajská StredaDAC 1904 Duna | 3 - 1 | MSK ZilinaMSK Zilina |
| 26 Feb 22 | r22 | TrencinTrencin | 2 - 2 | Tatran Liptovský MikulášTatran Liptov |
| |
| 04 Mar 22 | r01 | MFK RužomberokMFK Ružombero | 4 - 1 | DAC 1904 Dunajská StredaDAC 1904 Duna |
| 05 Mar 22 | r01 | MFK Zemplín MichalovceMFK Zemplín M | 1 - 0 | TrencinTrencin |
| 05 Mar 22 | r01 | FK PohronieFK Pohronie | 0 - 1 | ViOn Zlaté MoravceViOn Zlaté Mo |
| 05 Mar 22 | r01 | Tatran Liptovský MikulášTatran Liptov | 2 - 1 | FK SenicaFK Senica |
| 05 Mar 22 | r01 | FC Spartak TrnavaFC Spartak Tr | 0 - 1 | ŠKF SereďŠKF Sereď |
| 06 Mar 22 | r01 | MSK ZilinaMSK Zilina | 2 - 3 | Slovan BratislavaSlovan Bratis |
| |
| 11 Mar 22 | r02 | TrencinTrencin | 2 - 0 | FK PohronieFK Pohronie |
| 12 Mar 22 | r02 | FK SenicaFK Senica | 2 - 1 | MFK Zemplín MichalovceMFK Zemplín M |
| 12 Mar 22 | r02 | ViOn Zlaté MoravceViOn Zlaté Mo | 0 - 1 | Tatran Liptovský MikulášTatran Liptov |
| 12 Mar 22 | r02 | Slovan BratislavaSlovan Bratis | 1 - 1 | MFK RužomberokMFK Ružombero |
| 12 Mar 22 | r02 | ŠKF SereďŠKF Sereď | 1 - 1 | MSK ZilinaMSK Zilina |
| 13 Mar 22 | r02 | DAC 1904 Dunajská StredaDAC 1904 Duna | 1 - 1 | FC Spartak TrnavaFC Spartak Tr |
| |
| 19 Mar 22 | r03 | MSK ZilinaMSK Zilina | 2 - 2 | DAC 1904 Dunajská StredaDAC 1904 Duna |
| 19 Mar 22 | r03 | TrencinTrencin | 4 - 1 | FK SenicaFK Senica |
| 19 Mar 22 | r03 | MFK Zemplín MichalovceMFK Zemplín M | 1 - 0 | ViOn Zlaté MoravceViOn Zlaté Mo |
| 19 Mar 22 | r03 | FK PohronieFK Pohronie | 1 - 1 | Tatran Liptovský MikulášTatran Liptov |
| 19 Mar 22 | r03 | Slovan BratislavaSlovan Bratis | 5 - 1 | ŠKF SereďŠKF Sereď |
| 20 Mar 22 | r03 | MFK RužomberokMFK Ružombero | 0 - 0 | FC Spartak TrnavaFC Spartak Tr |
| |
| 01 Apr 22 | r04 | MSK ZilinaMSK Zilina | 0 - 2 | MFK RužomberokMFK Ružombero |
| 02 Apr 22 | r04 | Tatran Liptovský MikulášTatran Liptov | 0 - 3 | TrencinTrencin |
| 02 Apr 22 | r04 | ViOn Zlaté MoravceViOn Zlaté Mo | 3 - 2 | FK SenicaFK Senica |
| 02 Apr 22 | r04 | MFK Zemplín MichalovceMFK Zemplín M | 1 - 0 | FK PohronieFK Pohronie |
| 02 Apr 22 | r04 | DAC 1904 Dunajská StredaDAC 1904 Duna | 0 - 0 | ŠKF SereďŠKF Sereď |
| 03 Apr 22 | r04 | FC Spartak TrnavaFC Spartak Tr | 0 - 1 | Slovan BratislavaSlovan Bratis |
| |
| 08 Apr 22 | r05 | Tatran Liptovský MikulášTatran Liptov | 3 - 1 | MFK Zemplín MichalovceMFK Zemplín M |
| 09 Apr 22 | r05 | FK SenicaFK Senica | 2 - 1 | FK PohronieFK Pohronie |
| 09 Apr 22 | r05 | FC Spartak TrnavaFC Spartak Tr | 1 - 0 | MSK ZilinaMSK Zilina |
| 10 Apr 22 | r05 | Slovan BratislavaSlovan Bratis | 3 - 1 | DAC 1904 Dunajská StredaDAC 1904 Duna |
| 10 Apr 22 | r05 | ŠKF SereďŠKF Sereď | 1 - 3 | MFK RužomberokMFK Ružombero |
| |
| 15 Apr 22 | r06 | MFK RužomberokMFK Ružombero | 0 - 0 | Slovan BratislavaSlovan Bratis |
| 16 Apr 22 | r06 | FK SenicaFK Senica | 0 - 3 | Tatran Liptovský MikulášTatran Liptov |
| 16 Apr 22 | r06 | FK PohronieFK Pohronie | 1 - 1 | TrencinTrencin |
| 16 Apr 22 | r06 | DAC 1904 Dunajská StredaDAC 1904 Duna | 2 - 0 | MSK ZilinaMSK Zilina |
| 17 Apr 22 | r06 | ŠKF SereďŠKF Sereď | 0 - 2 | FC Spartak TrnavaFC Spartak Tr |
| 18 Apr 22 | r06 | ViOn Zlaté MoravceViOn Zlaté Mo | 1 - 1 | MFK Zemplín MichalovceMFK Zemplín M |
| |
| 23 Apr 22 | r07 | ViOn Zlaté MoravceViOn Zlaté Mo | 0 - 2 | TrencinTrencin |
| 23 Apr 22 | r07 | Tatran Liptovský MikulášTatran Liptov | 1 - 0 | FK PohronieFK Pohronie |
| 23 Apr 22 | r07 | MFK Zemplín MichalovceMFK Zemplín M | 1 - 0 | FK SenicaFK Senica |
| 23 Apr 22 | r07 | MSK ZilinaMSK Zilina | 1 - 1 | ŠKF SereďŠKF Sereď |
| 24 Apr 22 | r07 | FC Spartak TrnavaFC Spartak Tr | 0 - 0 | MFK RužomberokMFK Ružombero |
| 24 Apr 22 | r07 | DAC 1904 Dunajská StredaDAC 1904 Duna | 2 - 0 | Slovan BratislavaSlovan Bratis |
| |
| 26 Apr 22 | r05 | TrencinTrencin | 4 - 3 | ViOn Zlaté MoravceViOn Zlaté Mo |
| |
| 30 Apr 22 | r08 | FK PohronieFK Pohronie | 1 - 2 | MFK Zemplín MichalovceMFK Zemplín M |
| 30 Apr 22 | r08 | TrencinTrencin | 5 - 2 | Tatran Liptovský MikulášTatran Liptov |
| 30 Apr 22 | r08 | FK SenicaFK Senica | 0 - 0 | ViOn Zlaté MoravceViOn Zlaté Mo |
| 30 Apr 22 | r08 | ŠKF SereďŠKF Sereď | 0 - 0 | DAC 1904 Dunajská StredaDAC 1904 Duna |
| 01 May 22 | r08 | Slovan BratislavaSlovan Bratis | 1 - 0 | FC Spartak TrnavaFC Spartak Tr |
| 04 May 22 | r08 | MFK RužomberokMFK Ružombero | 3 - 0 | MSK ZilinaMSK Zilina |
| |
| 13 May 22 | r09 | MFK Zemplín MichalovceMFK Zemplín M | 1 - 2 | Tatran Liptovský MikulášTatran Liptov |
| 14 May 22 | r09 | ViOn Zlaté MoravceViOn Zlaté Mo | 1 - 3 | FK PohronieFK Pohronie |
| 14 May 22 | r09 | FK SenicaFK Senica | 0 - 3 | TrencinTrencin |
| 14 May 22 | r09 | MSK ZilinaMSK Zilina | 1 - 2 | FC Spartak TrnavaFC Spartak Tr |
| 14 May 22 | r09 | ŠKF SereďŠKF Sereď | 0 - 3 | Slovan BratislavaSlovan Bratis |
| 15 May 22 | r09 | DAC 1904 Dunajská StredaDAC 1904 Duna | 2 - 3 | MFK RužomberokMFK Ružombero |
| |
| 21 May 22 | r10 | Slovan BratislavaSlovan Bratis | 2 - 2 | MSK ZilinaMSK Zilina |
| 21 May 22 | r10 | Tatran Liptovský MikulášTatran Liptov | 0 - 2 | ViOn Zlaté MoravceViOn Zlaté Mo |
| 21 May 22 | r10 | TrencinTrencin | 2 - 2 | MFK Zemplín MichalovceMFK Zemplín M |
| 21 May 22 | r10 | FK PohronieFK Pohronie | 1 - 0 | FK SenicaFK Senica |
| 21 May 22 | r10 | FC Spartak TrnavaFC Spartak Tr | 1 - 0 | DAC 1904 Dunajská StredaDAC 1904 Duna |
| 21 May 22 | r10 | MFK RužomberokMFK Ružombero | 3 - 1 | ŠKF SereďŠKF Sereď |
| |
| 24 May 22 | r00 | ŠKF SereďŠKF Sereď | 0 - 2 | MSK ZilinaMSK Zilina |
| 24 May 22 | r00 | DAC 1904 Dunajská StredaDAC 1904 Duna | 4 - 2 | TrencinTrencin |
| 27 May 22 | r00 | DAC 1904 Dunajská StredaDAC 1904 Duna | 2 - 1 | TrencinTrencin |
| 27 May 22 | r00 | TrencinTrencin | 2 - 1 | DAC 1904 Dunajská StredaDAC 1904 Duna |
Team 2021-2022 Schedules
DAC 1904 Dunajská Streda
Dukla Banská Bystrica
Komárno
Košice
Ružomberok
Skalica
Slovan Bratislava
Spartak Trnava
Trenčín
Železiarne Podbrezová
Zemplín Michalovce
Žilina
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