| 31 Jul 21 | r01   | Kelty HeartsKelty Hearts | 2 - 0 | CowdenbeathCowdenbeath |
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| 07 Aug 21 | r02 | Stirling AlbionStirling Albi | 1 - 3 | Kelty HeartsKelty Hearts |
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| 14 Aug 21 | r03 | ForfarForfar | 2 - 2 | Kelty HeartsKelty Hearts |
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| 21 Aug 21 | r04 | Kelty HeartsKelty Hearts | 1 - 0 | Edinburgh CityEdinburgh Cit |
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| 28 Aug 21 | r05 | StenhousemuirStenhousemuir | 1 - 4 | Kelty HeartsKelty Hearts |
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| 11 Sep 21 | r06 | Kelty HeartsKelty Hearts | 1 - 1 | Elgin CityElgin City |
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| 18 Sep 21 | r07 | Albion RoversAlbion Rovers | 0 - 3 | Kelty HeartsKelty Hearts |
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| 25 Sep 21 | r08 | Kelty HeartsKelty Hearts | 1 - 0 | StranraerStranraer |
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| 02 Oct 21 | r09 | Kelty HeartsKelty Hearts | 2 - 1 | Annan AthleticAnnan Athleti |
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| 15 Oct 21 | r10 | Edinburgh CityEdinburgh Cit | 2 - 3 | Kelty HeartsKelty Hearts |
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| 30 Oct 21 | r11 | Kelty HeartsKelty Hearts | 1 - 1 | Stirling AlbionStirling Albi |
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| 06 Nov 21 | r12 | CowdenbeathCowdenbeath | 0 - 1 | Kelty HeartsKelty Hearts |
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| 13 Nov 21 | r13 | Kelty HeartsKelty Hearts | 1 - 0 | ForfarForfar |
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| 20 Nov 21 | r14 | Kelty HeartsKelty Hearts | 2 - 0 | StenhousemuirStenhousemuir |
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| 11 Dec 21 | r16 | Kelty HeartsKelty Hearts | 6 - 1 | Albion RoversAlbion Rovers |
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| 18 Dec 21 | r17 | StranraerStranraer | 0 - 4 | Kelty HeartsKelty Hearts |
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| 26 Dec 21 | r18 | Annan AthleticAnnan Athleti | 5 - 1 | Kelty HeartsKelty Hearts |
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| 08 Jan 22 | r20 | Stirling AlbionStirling Albi | 0 - 3 | Kelty HeartsKelty Hearts |
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| 15 Jan 22 | r21 | Kelty HeartsKelty Hearts | 2 - 2 | Edinburgh CityEdinburgh Cit |
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| 25 Jan 22 | r15 | Elgin CityElgin City | 2 - 0 | Kelty HeartsKelty Hearts |
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| 29 Jan 22 | r23 | Kelty HeartsKelty Hearts | 3 - 2 | StranraerStranraer |
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| 05 Feb 22 | r24 | Kelty HeartsKelty Hearts | 4 - 0 | Elgin CityElgin City |
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| 19 Feb 22 | r26 | ForfarForfar | 1 - 0 | Kelty HeartsKelty Hearts |
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| 22 Feb 22 | r19 | Kelty HeartsKelty Hearts | 1 - 0 | CowdenbeathCowdenbeath |
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| 26 Feb 22 | r27 | Kelty HeartsKelty Hearts | 3 - 1 | Annan AthleticAnnan Athleti |
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| 05 Mar 22 | r28 | CowdenbeathCowdenbeath | 0 - 1 | Kelty HeartsKelty Hearts |
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| 08 Mar 22 | r25 | StenhousemuirStenhousemuir | 0 - 1 | Kelty HeartsKelty Hearts |
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| 12 Mar 22 | r29 | Kelty HeartsKelty Hearts | 3 - 1 | Albion RoversAlbion Rovers |
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| 16 Mar 22 | r22 | Albion RoversAlbion Rovers | 0 - 0 | Kelty HeartsKelty Hearts |
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| 19 Mar 22 | r30 | Elgin CityElgin City | 0 - 0 | Kelty HeartsKelty Hearts |
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| 26 Mar 22 | r31 | Kelty HeartsKelty Hearts | 1 - 0 | StenhousemuirStenhousemuir |
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| 01 Apr 22 | r32 | Edinburgh CityEdinburgh Cit | 1 - 1 | Kelty HeartsKelty Hearts |
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| 09 Apr 22 | r33 | Kelty HeartsKelty Hearts | 1 - 1 | Stirling AlbionStirling Albi |
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| 16 Apr 22 | r34 | StranraerStranraer | 0 - 3 | Kelty HeartsKelty Hearts |
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| 23 Apr 22 | r35 | Kelty HeartsKelty Hearts | 1 - 1 | ForfarForfar |
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| 30 Apr 22 | r36 | Annan AthleticAnnan Athleti | 1 - 2 | Kelty HeartsKelty Hearts |
Team 2021-2022 Schedules
Annan Athletic
Clyde
Dumbarton
Edinburgh City
Elgin City
Forfar Athletic
Kelty Hearts
Stirling Albion
Stranraer
The Spartans
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