| 23 Oct 21 | r19        | TomskTomsk | 2 - 1 | Volgar AstrakhanVolgar Astrak |
| 23 Oct 21 | r19        | Chayka PeschanokopskoyeChayka Pescha | 2 - 1 | Volgar AstrakhanVolgar Astrak |
| 23 Oct 21 | r19        | Neftekhimik NizhnekamskNeftekhimik N | 3 - 1 | Tekstilshchik IvanovoTekstilshchik |
| 23 Oct 21 | r19        | Gazovik OrenburgGazovik Orenb | 2 - 0 | SKA-KhabarovskSKA-Khabarovs |
| 23 Oct 21 | r19        | Akron TolyattiAkron Tolyatt | 2 - 1 | Olimp-DolgoprudnyOlimp-Dolgopr |
| 23 Oct 21 | r19        | Torpedo MoscowTorpedo Mosco | 2 - 1 | FC Yenisey KrasnoyarskFC Yenisey Kr |
| 23 Oct 21 | r19        | Rotor VolgogradRotor Volgogr | 0 - 0 | Alania VladikavkazAlania Vladik |
| 23 Oct 21 | r19        | Fakel VoronezhFakel Voronez | 3 - 2 | Metallurg LipetskMetallurg Lip |
| 23 Oct 21 | r19        | KAMAZ Naberezhnye ChelnyKAMAZ Naberez | 4 - 1 | Spartak-2 MoscowSpartak-2 Mos |
| 23 Oct 21 | r19        | FC Krasnodar-2FC Krasnodar- | 1 - 2 | PFC Kuban KrasnodarPFC Kuban Kra |
| 23 Oct 21 | r19        | Baltika KaliningradBaltika Kalin | 1 - 0 | Veles MoscowVeles Moscow |