| 03 Oct 21 | r15        | TomskTomsk | 1 - 3 | Alania VladikavkazAlania Vladik |
| 03 Oct 21 | r15        | Chayka PeschanokopskoyeChayka Pescha | 1 - 3 | Alania VladikavkazAlania Vladik |
| 03 Oct 21 | r15        | Gazovik OrenburgGazovik Orenb | 2 - 1 | Spartak-2 MoscowSpartak-2 Mos |
| 03 Oct 21 | r15        | Metallurg LipetskMetallurg Lip | 1 - 1 | SKA-KhabarovskSKA-Khabarovs |
| 03 Oct 21 | r15        | Volgar AstrakhanVolgar Astrak | 0 - 1 | Veles MoscowVeles Moscow |
| 03 Oct 21 | r15        | Rotor VolgogradRotor Volgogr | 1 - 1 | Torpedo MoscowTorpedo Mosco |
| 03 Oct 21 | r15        | Akron TolyattiAkron Tolyatt | 1 - 0 | PFC Kuban KrasnodarPFC Kuban Kra |
| 03 Oct 21 | r15        | Fakel VoronezhFakel Voronez | 3 - 0 | Tekstilshchik IvanovoTekstilshchik |
| 03 Oct 21 | r15        | KAMAZ Naberezhnye ChelnyKAMAZ Naberez | 2 - 0 | FC Krasnodar-2FC Krasnodar- |
| 03 Oct 21 | r15        | Neftekhimik NizhnekamskNeftekhimik N | 2 - 3 | FC Yenisey KrasnoyarskFC Yenisey Kr |
| 03 Oct 21 | r15        | Baltika KaliningradBaltika Kalin | 1 - 1 | Olimp-DolgoprudnyOlimp-Dolgopr |