| 24 Aug 21 | r05        | Tepatitlán FCTepatitlán FC | 2 - 0 | VenadosVenados |
| 25 Aug 21 | r05        | Pumas TabascoPumas Tabasco | 0 - 2 | DoradosDorados |
| 25 Aug 21 | r05        | Tampico MaderoTampico Mader | 1 - 1 | TapatíoTapatío |
| 25 Aug 21 | r05        | TlaxcalaTlaxcala | 0 - 0 | AtlanteAtlante |
| 26 Aug 21 | r05        | CancúnCancún | 3 - 1 | Mineros de ZacatecasMineros de Za |
| 26 Aug 21 | r05        | Raya2Raya2 | 1 - 0 | CelayaCelaya |
| 27 Aug 21 | r05        | MoreliaMorelia | 2 - 1 | Correcaminos UATCorrecaminos |
| 29 Aug 21 | r05        | Leones Negros UDGLeones Negros | 1 - 1 | Alebrijes de OaxacaAlebrijes de |
| 28 Jan 22 | r05        | TlaxcalaTlaxcala | 1 - 0 | VenadosVenados |
| 29 Jan 22 | r05        | Mineros de ZacatecasMineros de Za | 1 - 0 | Tepatitlán FCTepatitlán FC |
| 29 Jan 22 | r05        | Alebrijes de OaxacaAlebrijes de | 1 - 1 | MoreliaMorelia |
| 30 Jan 22 | r05        | Correcaminos UATCorrecaminos | 0 - 2 | Cimarrones de SonoraCimarrones de |
| 30 Jan 22 | r05        | CelayaCelaya | 2 - 1 | Raya2Raya2 |
| 30 Jan 22 | r05        | TapatíoTapatío | 2 - 1 | Tampico MaderoTampico Mader |
| 31 Jan 22 | r05        | CancúnCancún | 1 - 2 | AtlanteAtlante |
| 31 Jan 22 | r05        | DoradosDorados | 0 - 1 | Leones Negros UDGLeones Negros |