| 01 Dec 21 | QF        | Tampico MaderoTampico Mader | 2 - 2 | MoreliaMorelia |
| 01 Dec 21 | QF        | Leones Negros UDGLeones Negros | 1 - 0 | CelayaCelaya |
| 02 Dec 21 | QF        | Tepatitlán FCTepatitlán FC | 0 - 1 | DoradosDorados |
| 03 Dec 21 | QF        | VenadosVenados | 0 - 2 | AtlanteAtlante |
| 04 Dec 21 | QF        | MoreliaMorelia | 0 - 2 | Tampico MaderoTampico Mader |
| 05 Dec 21 | QF        | DoradosDorados | 1 - 0 | Tepatitlán FCTepatitlán FC |
| 05 Dec 21 | QF        | AtlanteAtlante | 0 - 0 | VenadosVenados |
| 05 Dec 21 | QF        | CelayaCelaya | 3 - 0 | Leones Negros UDGLeones Negros |
| 27 Apr 22 | QF        | Mineros de ZacatecasMineros de Za | 3 - 3 | MoreliaMorelia |
| 27 Apr 22 | QF        | Cimarrones de SonoraCimarrones de | 1 - 3 | Alebrijes de OaxacaAlebrijes de |
| 29 Apr 22 | QF        | AtlanteAtlante | 2 - 0 | Leones Negros UDGLeones Negros |
| 29 Apr 22 | QF        | CancúnCancún | 0 - 1 | CelayaCelaya |
| 29 Apr 22 | QF        | MoreliaMorelia | 2 - 2 | Mineros de ZacatecasMineros de Za |
| 30 Apr 22 | QF        | Alebrijes de OaxacaAlebrijes de | 0 - 0 | Cimarrones de SonoraCimarrones de |
| 01 May 22 | QF        | Leones Negros UDGLeones Negros | 1 - 2 | AtlanteAtlante |
| 02 May 22 | QF        | CelayaCelaya | 2 - 1 | CancúnCancún |