| 20 Sep 20 | r01  | Floriana FCFloriana FC | 2 - 1 | Gżira UnitedGżira United |
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| 27 Sep 20 | r02 | Hibernians FCHibernians FC | 3 - 1 | Floriana FCFloriana FC |
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| 01 Oct 20 | r03 | Floriana FCFloriana FC | 3 - 2 | Sirens FCSirens FC |
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| 16 Oct 20 | r04 | Santa Lucia FCSanta Lucia F | 2 - 1 | Floriana FCFloriana FC |
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| 21 Oct 20 | r05 | Floriana FCFloriana FC | 1 - 0 | Senglea AthleticSenglea Athle |
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| 25 Oct 20 | r06 | Gudja UnitedGudja United | 1 - 2 | Floriana FCFloriana FC |
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| 22 Nov 20 | r08 | Balzan FCBalzan FC | 0 - 0 | Floriana FCFloriana FC |
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| 29 Nov 20 | r09 | Floriana FCFloriana FC | 0 - 2 | Mosta FCMosta FC |
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| 06 Dec 20 | r10 | VallettaValletta | 0 - 3 | Floriana FCFloriana FC |
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| 13 Dec 20 | r12 | Floriana FCFloriana FC | 0 - 1 | SliemaSliema |
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| 19 Dec 20 | r13 | Ħamrun SpartansĦamrun Sparta | 3 - 1 | Floriana FCFloriana FC |
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| 22 Dec 20 | r07 | Floriana FCFloriana FC | 2 - 5 | BirkirkaraBirkirkara |
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| 10 Jan 21 | r15 | Floriana FCFloriana FC | 0 - 0 | Zejtun CorinthiansZejtun Corint |
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| 13 Jan 21 | r11 | Tarxien RainbowsTarxien Rainb | 2 - 2 | Floriana FCFloriana FC |
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| 16 Jan 21 | r16 | Gżira UnitedGżira United | 4 - 1 | Floriana FCFloriana FC |
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| 23 Jan 21 | r17 | Floriana FCFloriana FC | 1 - 1 | Hibernians FCHibernians FC |
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| 27 Jan 21 | r14 | Floriana FCFloriana FC | 1 - 2 | Lija AthleticLija Athletic |
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| 30 Jan 21 | r18 | Sirens FCSirens FC | 2 - 1 | Floriana FCFloriana FC |
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| 05 Feb 21 | r19 | Floriana FCFloriana FC | 1 - 1 | Santa Lucia FCSanta Lucia F |
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| 13 Feb 21 | r20 | Senglea AthleticSenglea Athle | 0 - 2 | Floriana FCFloriana FC |
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| 20 Feb 21 | r21 | Floriana FCFloriana FC | 1 - 0 | Gudja UnitedGudja United |
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| 27 Feb 21 | r22 | BirkirkaraBirkirkara | 2 - 0 | Floriana FCFloriana FC |
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| 06 Mar 21 | r23 | Floriana FCFloriana FC | 0 - 0 | Balzan FCBalzan FC |
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| 13 Mar 21 | r24 | Mosta FCMosta FC | - | Floriana FCFloriana FC |
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| 03 Apr 21 | r25 | Floriana FCFloriana FC | - | VallettaValletta |
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| 11 Apr 21 | r26 | Floriana FCFloriana FC | - | Tarxien RainbowsTarxien Rainb |
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| 17 Apr 21 | r27 | SliemaSliema | - | Floriana FCFloriana FC |
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| 24 Apr 21 | r28 | Floriana FCFloriana FC | - | Ħamrun SpartansĦamrun Sparta |
Team 2020-2021 Schedules
Birkirkara
Floriana
Gżira United
Ħamrun Spartans
Hibernians
Marsaxlokk
Mosta
Naxxar Lions
Sliema Wanderers
Tarxien Rainbows
Valletta
Żabbar St Patrick
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