| 08 Aug 21 | r01  | RenovaRenova | 1 - 1 | SkopjeSkopje |
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| 15 Aug 21 | r02 | SkopjeSkopje | 0 - 0 | Bregalnica ŠtipBregalnica Št |
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| 18 Aug 21 | r03 | Makedonija GjPMakedonija Gj | 5 - 1 | SkopjeSkopje |
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| 22 Aug 21 | r04 | SkopjeSkopje | 1 - 0 | PelisterPelister |
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| 28 Aug 21 | r05 | ShkupiShkupi | 4 - 1 | SkopjeSkopje |
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| 12 Sep 21 | r06 | StrugaStruga | 1 - 0 | SkopjeSkopje |
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| 19 Sep 21 | r07 | SkopjeSkopje | 0 - 2 | Shkendija 79Shkendija 79 |
| |
| 26 Sep 21 | r08 | BorecBorec | 0 - 2 | SkopjeSkopje |
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| 02 Oct 21 | r09 | SkopjeSkopje | 0 - 0 | Akademija PandevAkademija Pan |
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| 15 Oct 21 | r10 | RabotnichkiRabotnichki | 0 - 1 | SkopjeSkopje |
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| 24 Oct 21 | r11 | SkopjeSkopje | 2 - 1 | TikvešTikveš |
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| 30 Oct 21 | r12 | SkopjeSkopje | 0 - 0 | RenovaRenova |
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| 06 Nov 21 | r13 | Bregalnica ŠtipBregalnica Št | 2 - 1 | SkopjeSkopje |
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| 20 Nov 21 | r14 | SkopjeSkopje | 1 - 2 | Makedonija GjPMakedonija Gj |
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| 28 Nov 21 | r15 | PelisterPelister | 0 - 0 | SkopjeSkopje |
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| 05 Dec 21 | r16 | SkopjeSkopje | 1 - 3 | ShkupiShkupi |
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| 08 Dec 21 | r17 | SkopjeSkopje | 1 - 0 | StrugaStruga |
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| 12 Dec 21 | r18 | Shkendija 79Shkendija 79 | 1 - 0 | SkopjeSkopje |
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| 13 Feb 22 | r19 | SkopjeSkopje | 1 - 1 | BorecBorec |
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| 20 Feb 22 | r20 | Akademija PandevAkademija Pan | 5 - 0 | SkopjeSkopje |
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| 27 Feb 22 | r21 | SkopjeSkopje | 0 - 1 | RabotnichkiRabotnichki |
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| 05 Mar 22 | r22 | TikvešTikveš | 3 - 0 | SkopjeSkopje |
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| 13 Mar 22 | r23 | Makedonija GjPMakedonija Gj | 1 - 1 | SkopjeSkopje |
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| 19 Mar 22 | r24 | SkopjeSkopje | 0 - 2 | Shkendija 79Shkendija 79 |
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| 03 Apr 22 | r25 | Akademija PandevAkademija Pan | 1 - 2 | SkopjeSkopje |
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| 06 Apr 22 | r26 | SkopjeSkopje | 0 - 0 | ShkupiShkupi |
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| 10 Apr 22 | r27 | StrugaStruga | 1 - 0 | SkopjeSkopje |
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| 17 Apr 22 | r28 | SkopjeSkopje | 1 - 2 | TikvešTikveš |
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| 22 Apr 22 | r29 | RabotnichkiRabotnichki | 0 - 1 | SkopjeSkopje |
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| 01 May 22 | r30 | BorecBorec | 1 - 0 | SkopjeSkopje |
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| 04 May 22 | r31 | SkopjeSkopje | 4 - 2 | PelisterPelister |
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| 08 May 22 | r32 | RenovaRenova | 2 - 0 | SkopjeSkopje |
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| 15 May 22 | r33 | SkopjeSkopje | 4 - 1 | Bregalnica ŠtipBregalnica Št |
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| 22 May 22 | r00 | SkopjeSkopje | 2 - 1 | BelasicaBelasica |
Team 2021-2022 Schedules
Arsimi
Bashkimi
Bregalnica Štip
Shkëndija
Shkëndija Haraçinë
Sileks
Skopje
Struga
Tikvesh
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