| 14 Aug 21 | r01        | Hyde UnitedHyde United | 0 - 1 | Atherton CollieriesAtherton Coll |
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| 17 Aug 21 | r02        | Bamber BridgeBamber Bridge | 4 - 1 | Hyde UnitedHyde United |
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| 21 Aug 21 | r03        | MatlockMatlock | 2 - 1 | Hyde UnitedHyde United |
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| 24 Aug 21 | r04        | Hyde UnitedHyde United | 3 - 0 | Grantham TownGrantham Town |
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| 28 Aug 21 | r05        | Hyde UnitedHyde United | 2 - 1 | FC United of ManchesterFC United of |
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| 30 Aug 21 | r06        | Mickleover SportsMickleover Sp | 3 - 2 | Hyde UnitedHyde United |
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| 07 Sep 21 | r07        | Nantwich TownNantwich Town | 0 - 2 | Hyde UnitedHyde United |
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| 11 Sep 21 | r08        | Hyde UnitedHyde United | 1 - 2 | South ShieldsSouth Shields |
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| 14 Sep 21 | r09        | Hyde UnitedHyde United | 1 - 0 | Stafford RangersStafford Rang |
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| 25 Sep 21 | r10        | Whitby TownWhitby Town | 1 - 0 | Hyde UnitedHyde United |
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| 28 Sep 21 | r11        | Hyde UnitedHyde United | 2 - 2 | Morpeth TownMorpeth Town |
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| 05 Oct 21 | r13        | WittonWitton | 4 - 2 | Hyde UnitedHyde United |
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| 09 Oct 21 | r14        | Hyde UnitedHyde United | 0 - 1 | Lancaster CityLancaster Cit |
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| 12 Oct 21 | r15        | Hyde UnitedHyde United | 1 - 3 | RadcliffeRadcliffe |
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| 16 Oct 21 | r12        | Basford Utd.Basford Utd. | 2 - 0 | Hyde UnitedHyde United |
| 16 Oct 21 | r12        | Basford Utd.Basford Utd. | 2 - 0 | Hyde UnitedHyde United |
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| 23 Oct 21 | r17        | Hyde UnitedHyde United | 3 - 2 | Scarborough AthleticScarborough A |
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| 06 Nov 21 | r18        | Warrington TownWarrington To | 1 - 0 | Hyde UnitedHyde United |
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| 13 Nov 21 | r16        | Buxton F.C.Buxton F.C. | 3 - 0 | Hyde UnitedHyde United |
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| 20 Nov 21 | r19        | Hyde UnitedHyde United | 2 - 1 | AshtonAshton |
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| 04 Dec 21 | r21        | Hyde UnitedHyde United | 1 - 0 | Nantwich TownNantwich Town |
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| 11 Dec 21 | r22        | South ShieldsSouth Shields | 1 - 2 | Hyde UnitedHyde United |
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| 21 Dec 21 | r20        | GainsboroughGainsborough | 1 - 1 | Hyde UnitedHyde United |
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| 27 Dec 21 | r24        | StalybridgeStalybridge | 1 - 1 | Hyde UnitedHyde United |
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| 01 Jan 22 | r25        | Hyde UnitedHyde United | 1 - 4 | Mickleover SportsMickleover Sp |
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| 11 Jan 22 | r23        | Hyde UnitedHyde United | 2 - 3 | MatlockMatlock |
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| 15 Jan 22 | r27        | Stafford RangersStafford Rang | 0 - 0 | Hyde UnitedHyde United |
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| 22 Jan 22 | r28        | Hyde UnitedHyde United | 1 - 2 | Whitby TownWhitby Town |
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| 29 Jan 22 | r29        | Hyde UnitedHyde United | 1 - 2 | Buxton F.C.Buxton F.C. |
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| 05 Feb 22 | r30        | Scarborough AthleticScarborough A | 1 - 1 | Hyde UnitedHyde United |
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| 08 Feb 22 | r31        | RadcliffeRadcliffe | 3 - 2 | Hyde UnitedHyde United |
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| 12 Feb 22 | r32        | Hyde UnitedHyde United | 2 - 1 | Warrington TownWarrington To |
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| 19 Feb 22 | r33        | Morpeth TownMorpeth Town | 2 - 2 | Hyde UnitedHyde United |
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| 26 Feb 22 | r34        | Hyde UnitedHyde United | 0 - 1 | Basford Utd.Basford Utd. |
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| 05 Mar 22 | r26        | Atherton CollieriesAtherton Coll | 0 - 1 | Hyde UnitedHyde United |
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| 12 Mar 22 | r35        | Lancaster CityLancaster Cit | 0 - 0 | Hyde UnitedHyde United |
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| 19 Mar 22 | r36        | Hyde UnitedHyde United | 3 - 2 | WittonWitton |
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| 26 Mar 22 | r37        | Hyde UnitedHyde United | 1 - 0 | GainsboroughGainsborough |
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| 02 Apr 22 | r38        | AshtonAshton | 0 - 3 | Hyde UnitedHyde United |
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| 09 Apr 22 | r39        | Hyde UnitedHyde United | 0 - 4 | Bamber BridgeBamber Bridge |
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| 16 Apr 22 | r40        | Grantham TownGrantham Town | 2 - 0 | Hyde UnitedHyde United |
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| 18 Apr 22 | r41        | Hyde UnitedHyde United | 2 - 2 | StalybridgeStalybridge |
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| 23 Apr 22 | r42        | FC United of ManchesterFC United of | 0 - 2 | Hyde UnitedHyde United |