| 01 Jan 22 | r25        | Basford Utd.Basford Utd. | 0 - 1 | Grantham TownGrantham Town |
| 01 Jan 22 | r25        | Buxton F.C.Buxton F.C. | 2 - 3 | Stafford RangersStafford Rang |
| 01 Jan 22 | r25        | Hyde UnitedHyde United | 1 - 4 | Mickleover SportsMickleover Sp |
| 01 Jan 22 | r25        | Lancaster CityLancaster Cit | 0 - 0 | Atherton CollieriesAtherton Coll |
| 01 Jan 22 | r25        | Morpeth TownMorpeth Town | 2 - 0 | Whitby TownWhitby Town |
| 01 Jan 22 | r25        | RadcliffeRadcliffe | 3 - 3 | FC United of ManchesterFC United of |
| 01 Jan 22 | r25        | South ShieldsSouth Shields | 1 - 0 | Scarborough AthleticScarborough A |
| 01 Jan 22 | r25        | Warrington TownWarrington To | 4 - 1 | Bamber BridgeBamber Bridge |
| 01 Mar 22 | r25        | Nantwich TownNantwich Town | 1 - 0 | WittonWitton |
| 05 Mar 22 | r25        | AshtonAshton | 2 - 1 | StalybridgeStalybridge |
| 05 Mar 22 | r25        | GainsboroughGainsborough | 1 - 2 | MatlockMatlock |