| 18 Dec 21 | r23        | AshtonAshton | 3 - 0 | Mickleover SportsMickleover Sp |
| 18 Dec 21 | r23        | Basford Utd.Basford Utd. | 2 - 0 | Atherton CollieriesAtherton Coll |
| 18 Dec 21 | r23        | Buxton F.C.Buxton F.C. | 1 - 2 | FC United of ManchesterFC United of |
| 18 Dec 21 | r23        | GainsboroughGainsborough | 2 - 0 | Bamber BridgeBamber Bridge |
| 18 Dec 21 | r23        | Warrington TownWarrington To | 0 - 2 | Scarborough AthleticScarborough A |
| 11 Jan 22 | r23        | Hyde UnitedHyde United | 2 - 3 | MatlockMatlock |
| 25 Jan 22 | r23        | Morpeth TownMorpeth Town | 1 - 1 | StalybridgeStalybridge |
| 25 Jan 22 | r23        | RadcliffeRadcliffe | 0 - 1 | Stafford RangersStafford Rang |
| 25 Jan 22 | r23        | South ShieldsSouth Shields | 3 - 1 | WittonWitton |
| 01 Feb 22 | r23        | Lancaster CityLancaster Cit | 1 - 1 | Grantham TownGrantham Town |
| 05 Mar 22 | r23        | Nantwich TownNantwich Town | 1 - 0 | Whitby TownWhitby Town |