| 19 Mar 21 | r01   | DroghedaDrogheda | 1 - 0 | Waterford FCWaterford FC |
| |
| 26 Mar 21 | r02 | Waterford FCWaterford FC | 1 - 2 | SligoSligo |
| |
| 03 Apr 21 | r03 | Derry CityDerry City | 1 - 2 | Waterford FCWaterford FC |
| |
| 10 Apr 21 | r04 | Finn Harps FCFinn Harps FC | 2 - 1 | Waterford FCWaterford FC |
| |
| 16 Apr 21 | r05  | Waterford FCWaterford FC | 0 - 1 | BohemiansBohemians |
| |
| 20 Apr 21 | r06 | St PatricksSt Patricks | 1 - 0 | Waterford FCWaterford FC |
| |
| 24 Apr 21 | r07 | Waterford FCWaterford FC | 1 - 0 | Longford TownLongford Town |
| |
| 30 Apr 21 | r08 | Waterford FCWaterford FC | 0 - 3 | DundalkDundalk |
| |
| 03 May 21 | r09 | ShamrockShamrock | 3 - 0 | Waterford FCWaterford FC |
| |
| 08 May 21 | r10 | Waterford FCWaterford FC | 0 - 7 | DroghedaDrogheda |
| |
| 15 May 21 | r11 | SligoSligo | 3 - 0 | Waterford FCWaterford FC |
| |
| 21 May 21 | r12 | Waterford FCWaterford FC | 0 - 1 | Derry CityDerry City |
| |
| 24 May 21 | r13 | Waterford FCWaterford FC | 1 - 2 | Finn Harps FCFinn Harps FC |
| |
| 29 May 21 | r14 | BohemiansBohemians | 3 - 0 | Waterford FCWaterford FC |
| |
| 11 Jun 21 | r15 | DundalkDundalk | 1 - 3 | Waterford FCWaterford FC |
| |
| 18 Jun 21 | r16 | Waterford FCWaterford FC | 1 - 4 | ShamrockShamrock |
| |
| 21 Jun 21 | r17 | Longford TownLongford Town | 1 - 2 | Waterford FCWaterford FC |
| |
| 25 Jun 21 | r18 | Waterford FCWaterford FC | 1 - 1 | St PatricksSt Patricks |
| |
| 02 Jul 21 | r19 | Derry CityDerry City | 2 - 0 | Waterford FCWaterford FC |
| |
| 09 Jul 21 | r20 | Finn Harps FCFinn Harps FC | 0 - 1 | Waterford FCWaterford FC |
| |
| 18 Jul 21 | r21 | Waterford FCWaterford FC | 1 - 0 | SligoSligo |
| |
| 30 Jul 21 | r22 | DroghedaDrogheda | 1 - 2 | Waterford FCWaterford FC |
| |
| 07 Aug 21 | r23 | Waterford FCWaterford FC | 1 - 0 | BohemiansBohemians |
| |
| 13 Aug 21 | r24 | St PatricksSt Patricks | 2 - 1 | Waterford FCWaterford FC |
| |
| 20 Aug 21 | r25 | Waterford FCWaterford FC | 4 - 1 | Longford TownLongford Town |
| |
| 03 Sep 21 | r26 | Waterford FCWaterford FC | 1 - 1 | DundalkDundalk |
| |
| 10 Sep 21 | r27 | ShamrockShamrock | 2 - 0 | Waterford FCWaterford FC |
| |
| 24 Sep 21 | r28 | Waterford FCWaterford FC | 1 - 0 | DroghedaDrogheda |
| |
| 02 Oct 21 | r29 | SligoSligo | 1 - 1 | Waterford FCWaterford FC |
| |
| 15 Oct 21 | r31 | Waterford FCWaterford FC | 4 - 1 | Finn Harps FCFinn Harps FC |
| |
| 25 Oct 21 | r32 | BohemiansBohemians | 1 - 2 | Waterford FCWaterford FC |
| |
| 29 Oct 21 | r33 | DundalkDundalk | 1 - 0 | Waterford FCWaterford FC |
| |
| 02 Nov 21 | r30 | Waterford FCWaterford FC | 2 - 2 | Derry CityDerry City |
| |
| 05 Nov 21 | r34 | Waterford FCWaterford FC | 1 - 3 | ShamrockShamrock |
| |
| 13 Nov 21 | r35 | Longford TownLongford Town | 1 - 1 | Waterford FCWaterford FC |
| |
| 19 Nov 21 | r36 | Waterford FCWaterford FC | 0 - 0 | St PatricksSt Patricks |
| |
| 26 Nov 21 | r00 | Waterford FCWaterford FC | 1 - 2 | UCDUCD |
Team 2021 Schedules
Bohemians
Derry City
Drogheda United
Dundalk
Galway United
Shamrock Rovers
Shelbourne
Sligo Rovers
St Patrick's Athletic
Waterford
League Table
List
Poster
= Banner Image 
= Fanart Image 
= Timeline Details