| 19 Mar 21 | r01   | DroghedaDrogheda | 1 - 0 | Waterford FCWaterford FC |
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| 27 Mar 21 | r02 | St PatricksSt Patricks | 2 - 1 | DroghedaDrogheda |
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| 03 Apr 21 | r03 | DroghedaDrogheda | 1 - 1 | Finn Harps FCFinn Harps FC |
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| 10 Apr 21 | r04 | Longford TownLongford Town | 0 - 4 | DroghedaDrogheda |
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| 16 Apr 21 | r05  | Derry CityDerry City | 1 - 1 | DroghedaDrogheda |
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| 20 Apr 21 | r06 | DroghedaDrogheda | 0 - 1 | ShamrockShamrock |
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| 24 Apr 21 | r07 | DundalkDundalk | 2 - 1 | DroghedaDrogheda |
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| 30 Apr 21 | r08 | DroghedaDrogheda | 1 - 1 | SligoSligo |
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| 03 May 21 | r09 | DroghedaDrogheda | 1 - 1 | BohemiansBohemians |
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| 08 May 21 | r10 | Waterford FCWaterford FC | 0 - 7 | DroghedaDrogheda |
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| 14 May 21 | r11 | DroghedaDrogheda | 3 - 1 | St PatricksSt Patricks |
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| 21 May 21 | r12 | Finn Harps FCFinn Harps FC | 0 - 1 | DroghedaDrogheda |
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| 24 May 21 | r13 | DroghedaDrogheda | 4 - 1 | Longford TownLongford Town |
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| 28 May 21 | r14 | DroghedaDrogheda | 1 - 2 | Derry CityDerry City |
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| 12 Jun 21 | r15 | SligoSligo | 1 - 2 | DroghedaDrogheda |
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| 18 Jun 21 | r16 | BohemiansBohemians | 5 - 0 | DroghedaDrogheda |
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| 21 Jun 21 | r17 | DroghedaDrogheda | 0 - 1 | DundalkDundalk |
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| 25 Jun 21 | r18 | ShamrockShamrock | 1 - 1 | DroghedaDrogheda |
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| 02 Jul 21 | r19 | DroghedaDrogheda | 3 - 1 | Finn Harps FCFinn Harps FC |
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| 10 Jul 21 | r20 | Longford TownLongford Town | 1 - 1 | DroghedaDrogheda |
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| 16 Jul 21 | r21 | St PatricksSt Patricks | 2 - 0 | DroghedaDrogheda |
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| 30 Jul 21 | r22 | DroghedaDrogheda | 1 - 2 | Waterford FCWaterford FC |
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| 06 Aug 21 | r23 | Derry CityDerry City | 3 - 0 | DroghedaDrogheda |
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| 15 Aug 21 | r24 | DroghedaDrogheda | 0 - 1 | ShamrockShamrock |
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| 20 Aug 21 | r25 | DundalkDundalk | 1 - 2 | DroghedaDrogheda |
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| 03 Sep 21 | r26 | DroghedaDrogheda | 0 - 0 | SligoSligo |
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| 10 Sep 21 | r27 | DroghedaDrogheda | 3 - 2 | BohemiansBohemians |
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| 24 Sep 21 | r28 | Waterford FCWaterford FC | 1 - 0 | DroghedaDrogheda |
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| 01 Oct 21 | r29 | DroghedaDrogheda | 0 - 1 | St PatricksSt Patricks |
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| 15 Oct 21 | r31 | DroghedaDrogheda | 2 - 0 | Longford TownLongford Town |
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| 24 Oct 21 | r32 | DroghedaDrogheda | 1 - 0 | Derry CityDerry City |
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| 29 Oct 21 | r33 | SligoSligo | 2 - 0 | DroghedaDrogheda |
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| 01 Nov 21 | r30 | Finn Harps FCFinn Harps FC | 0 - 0 | DroghedaDrogheda |
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| 04 Nov 21 | r35 | DroghedaDrogheda | 0 - 1 | DundalkDundalk |
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| 07 Nov 21 | r34 | BohemiansBohemians | 2 - 1 | DroghedaDrogheda |
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| 19 Nov 21 | r36 | ShamrockShamrock | 2 - 1 | DroghedaDrogheda |
Team 2021 Schedules
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Derry City
Drogheda United
Dundalk
Galway United
Shamrock Rovers
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Sligo Rovers
St Patrick's Athletic
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