| 08 Aug 21 | r01   | ADO Den HaagADO Den Haag | 2 - 0 | Jong AjaxJong Ajax |
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| 16 Aug 21 | r02  | Jong AjaxJong Ajax | 1 - 2 | FC DordrechtFC Dordrecht |
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| 20 Aug 21 | r03 | FC Den BoschFC Den Bosch | 2 - 3 | Jong AjaxJong Ajax |
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| 27 Aug 21 | r04 | Jong AjaxJong Ajax | 1 - 2 | ExcelsiorExcelsior |
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| 10 Sep 21 | r06 | Jong PSVJong PSV | 3 - 1 | Jong AjaxJong Ajax |
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| 13 Sep 21 | r05 | Jong AjaxJong Ajax | 6 - 3 | NAC BredaNAC Breda |
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| 17 Sep 21 | r07 | Almere City FCAlmere City F | 2 - 4 | Jong AjaxJong Ajax |
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| 27 Sep 21 | r08 | Jong AjaxJong Ajax | 3 - 1 | MVV MaastrichtMVV Maastrich |
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| 01 Oct 21 | r09 | Helmond SportHelmond Sport | 3 - 1 | Jong AjaxJong Ajax |
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| 15 Oct 21 | r11 | Jong AjaxJong Ajax | 3 - 1 | Jong UtrechtJong Utrecht |
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| 18 Oct 21 | r10 | Jong AZJong AZ | 1 - 1 | Jong AjaxJong Ajax |
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| 22 Oct 21 | r12 | FC EindhovenFC Eindhoven | 1 - 3 | Jong AjaxJong Ajax |
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| 01 Nov 21 | r13 | Jong AjaxJong Ajax | 3 - 0 | SC TelstarSC Telstar |
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| 05 Nov 21 | r14 | VVV-VenloVVV-Venlo | 1 - 3 | Jong AjaxJong Ajax |
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| 19 Nov 21 | r16 | Jong AjaxJong Ajax | 4 - 4 | FC VolendamFC Volendam |
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| 22 Nov 21 | r15 | Jong AjaxJong Ajax | 2 - 1 | Roda JCRoda JC |
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| 26 Nov 21 | r17 | De GraafschapDe Graafschap | 1 - 3 | Jong AjaxJong Ajax |
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| 06 Dec 21 | r18 | Jong AjaxJong Ajax | 1 - 0 | FC EmmenFC Emmen |
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| 10 Dec 21 | r19 | TOP OssTOP Oss | 1 - 1 | Jong AjaxJong Ajax |
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| 20 Dec 21 | r20 | Jong AjaxJong Ajax | 1 - 1 | Helmond SportHelmond Sport |
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| 10 Jan 22 | r21 | Jong UtrechtJong Utrecht | 0 - 2 | Jong AjaxJong Ajax |
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| 17 Jan 22 | r22 | Jong AjaxJong Ajax | 2 - 1 | FC Den BoschFC Den Bosch |
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| 23 Jan 22 | r23 | SC TelstarSC Telstar | 1 - 0 | Jong AjaxJong Ajax |
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| 04 Feb 22 | r25 | Jong AjaxJong Ajax | 2 - 1 | Jong AZJong AZ |
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| 07 Feb 22 | r24 | Jong AjaxJong Ajax | 2 - 0 | Jong PSVJong PSV |
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| 11 Feb 22 | r26 | ExcelsiorExcelsior | 6 - 2 | Jong AjaxJong Ajax |
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| 21 Feb 22 | r27 | Jong AjaxJong Ajax | 1 - 3 | Almere City FCAlmere City F |
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| 25 Feb 22 | r28 | FC EmmenFC Emmen | 2 - 1 | Jong AjaxJong Ajax |
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| 07 Mar 22 | r29 | Jong AjaxJong Ajax | 6 - 3 | ADO Den HaagADO Den Haag |
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| 11 Mar 22 | r30 | FC DordrechtFC Dordrecht | 3 - 3 | Jong AjaxJong Ajax |
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| 18 Mar 22 | r31 | Jong AjaxJong Ajax | 2 - 2 | FC EindhovenFC Eindhoven |
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| 01 Apr 22 | r33 | NAC BredaNAC Breda | 0 - 0 | Jong AjaxJong Ajax |
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| 04 Apr 22 | r32 | Jong AjaxJong Ajax | 4 - 1 | TOP OssTOP Oss |
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| 08 Apr 22 | r34 | Roda JCRoda JC | 2 - 2 | Jong AjaxJong Ajax |
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| 16 Apr 22 | r35 | FC VolendamFC Volendam | 3 - 1 | Jong AjaxJong Ajax |
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| 25 Apr 22 | r36  | Jong AjaxJong Ajax | 6 - 1 | VVV-VenloVVV-Venlo |
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| 29 Apr 22 | r37 | MVV MaastrichtMVV Maastrich | 1 - 0 | Jong AjaxJong Ajax |
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| 06 May 22 | r38 | Jong AjaxJong Ajax | 1 - 1 | De GraafschapDe Graafschap |
Team 2021-2022 Schedules
ADO Den Haag
Almere City
De Graafschap
FC Den Bosch
FC Dordrecht
FC Eindhoven
FC Emmen
Helmond Sport
Jong Ajax
Jong AZ
Jong PSV
Jong Utrecht
MVV Maastricht
RKC Waalwijk
Roda JC
SC Cambuur
TOP Oss
VVV-Venlo
Willem II
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