| 09 Aug 21 | r01    | Jong AZJong AZ | 2 - 1 | Almere City FCAlmere City F |
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| 13 Aug 21 | r02 | Almere City FCAlmere City F | 1 - 1 | Jong UtrechtJong Utrecht |
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| 21 Aug 21 | r03 | VVV-VenloVVV-Venlo | 2 - 1 | Almere City FCAlmere City F |
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| 27 Aug 21 | r04 | Roda JCRoda JC | 3 - 4 | Almere City FCAlmere City F |
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| 04 Sep 21 | r05 | Almere City FCAlmere City F | 3 - 0 | TOP OssTOP Oss |
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| 10 Sep 21 | r06 | SC TelstarSC Telstar | 1 - 1 | Almere City FCAlmere City F |
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| 17 Sep 21 | r07 | Almere City FCAlmere City F | 2 - 4 | Jong AjaxJong Ajax |
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| 24 Sep 21 | r08 | Almere City FCAlmere City F | 2 - 2 | FC DordrechtFC Dordrecht |
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| 01 Oct 21 | r09 | FC VolendamFC Volendam | 3 - 2 | Almere City FCAlmere City F |
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| 10 Oct 21 | r10 | Almere City FCAlmere City F | 1 - 2 | De GraafschapDe Graafschap |
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| 15 Oct 21 | r11 | FC Den BoschFC Den Bosch | 1 - 0 | Almere City FCAlmere City F |
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| 22 Oct 21 | r12 | Almere City FCAlmere City F | 3 - 5 | Jong PSVJong PSV |
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| 01 Nov 21 | r13 | Helmond SportHelmond Sport | 1 - 2 | Almere City FCAlmere City F |
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| 07 Nov 21 | r14 | Almere City FCAlmere City F | 1 - 3 | ADO Den HaagADO Den Haag |
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| 14 Nov 21 | r15 | ExcelsiorExcelsior | 4 - 4 | Almere City FCAlmere City F |
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| 19 Nov 21 | r16 | Almere City FCAlmere City F | 0 - 2 | MVV MaastrichtMVV Maastrich |
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| 29 Nov 21 | r17 | FC EmmenFC Emmen | 3 - 0 | Almere City FCAlmere City F |
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| 03 Dec 21 | r18 | Almere City FCAlmere City F | 2 - 0 | FC EindhovenFC Eindhoven |
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| 10 Dec 21 | r19 | NAC BredaNAC Breda | 1 - 1 | Almere City FCAlmere City F |
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| 17 Dec 21 | r20 | Almere City FCAlmere City F | 2 - 3 | FC VolendamFC Volendam |
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| 10 Jan 22 | r21 | Jong PSVJong PSV | 5 - 1 | Almere City FCAlmere City F |
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| 14 Jan 22 | r22 | Almere City FCAlmere City F | 0 - 4 | Roda JCRoda JC |
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| 21 Jan 22 | r23 | De GraafschapDe Graafschap | 1 - 0 | Almere City FCAlmere City F |
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| 30 Jan 22 | r24 | Almere City FCAlmere City F | 0 - 0 | SC TelstarSC Telstar |
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| 04 Feb 22 | r25 | FC DordrechtFC Dordrecht | 2 - 2 | Almere City FCAlmere City F |
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| 11 Feb 22 | r26 | Almere City FCAlmere City F | 0 - 0 | FC EmmenFC Emmen |
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| 21 Feb 22 | r27 | Jong AjaxJong Ajax | 1 - 3 | Almere City FCAlmere City F |
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| 25 Feb 22 | r28 | Almere City FCAlmere City F | 0 - 1 | VVV-VenloVVV-Venlo |
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| 07 Mar 22 | r29 | Jong UtrechtJong Utrecht | 1 - 2 | Almere City FCAlmere City F |
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| 11 Mar 22 | r30 | Almere City FCAlmere City F | 3 - 0 | Helmond SportHelmond Sport |
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| 18 Mar 22 | r31 | Almere City FCAlmere City F | 2 - 0 | FC Den BoschFC Den Bosch |
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| 27 Mar 22 | r32 | MVV MaastrichtMVV Maastrich | 0 - 3 | Almere City FCAlmere City F |
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| 01 Apr 22 | r33 | Almere City FCAlmere City F | 3 - 0 | ExcelsiorExcelsior |
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| 08 Apr 22 | r34 | FC EindhovenFC Eindhoven | 3 - 1 | Almere City FCAlmere City F |
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| 16 Apr 22 | r35 | Almere City FCAlmere City F | 1 - 2 | NAC BredaNAC Breda |
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| 22 Apr 22 | r36 | TOP OssTOP Oss | 2 - 3 | Almere City FCAlmere City F |
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| 29 Apr 22 | r37 | ADO Den HaagADO Den Haag | 1 - 0 | Almere City FCAlmere City F |
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| 06 May 22 | r38 | Almere City FCAlmere City F | 0 - 3 | Jong AZJong AZ |
Team 2021-2022 Schedules
ADO Den Haag
Almere City
De Graafschap
FC Den Bosch
FC Dordrecht
FC Eindhoven
FC Emmen
Helmond Sport
Jong Ajax
Jong AZ
Jong PSV
Jong Utrecht
MVV Maastricht
RKC Waalwijk
Roda JC
SC Cambuur
TOP Oss
VVV-Venlo
Willem II
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