| 06 Aug 21 | r01   | FC Den BoschFC Den Bosch | 2 - 0 | Helmond SportHelmond Sport |
| 06 Aug 21 | r01 | FC DordrechtFC Dordrecht | 1 - 1 | Jong PSVJong PSV |
| 06 Aug 21 | r01 | FC EindhovenFC Eindhoven | 2 - 2 | FC VolendamFC Volendam |
| 06 Aug 21 | r01 | ExcelsiorExcelsior | 0 - 1 | TOP OssTOP Oss |
| 06 Aug 21 | r01 | SC TelstarSC Telstar | 1 - 1 | FC EmmenFC Emmen |
| 07 Aug 21 | r01 | De GraafschapDe Graafschap | 0 - 3 | Roda JCRoda JC |
| 08 Aug 21 | r01 | ADO Den HaagADO Den Haag | 2 - 0 | Jong AjaxJong Ajax |
| 08 Aug 21 | r01 | VVV-VenloVVV-Venlo | 2 - 2 | NAC BredaNAC Breda |
| 09 Aug 21 | r01  | Jong AZJong AZ | 2 - 1 | Almere City FCAlmere City F |
| 09 Aug 21 | r01 | Jong UtrechtJong Utrecht | 0 - 1 | MVV MaastrichtMVV Maastrich |
| |
| 13 Aug 21 | r02 | Almere City FCAlmere City F | 1 - 1 | Jong UtrechtJong Utrecht |
| 13 Aug 21 | r02 | FC EmmenFC Emmen | 0 - 1 | FC EindhovenFC Eindhoven |
| 13 Aug 21 | r02 | Helmond SportHelmond Sport | 1 - 2 | Jong AZJong AZ |
| 13 Aug 21 | r02 | MVV MaastrichtMVV Maastrich | 1 - 3 | De GraafschapDe Graafschap |
| 13 Aug 21 | r02 | NAC BredaNAC Breda | 2 - 2 | SC TelstarSC Telstar |
| 13 Aug 21 | r02 | TOP OssTOP Oss | 2 - 1 | VVV-VenloVVV-Venlo |
| 13 Aug 21 | r02 | Roda JCRoda JC | 1 - 2 | ExcelsiorExcelsior |
| 13 Aug 21 | r02 | FC VolendamFC Volendam | 1 - 3 | ADO Den HaagADO Den Haag |
| 16 Aug 21 | r02 | Jong AjaxJong Ajax | 1 - 2 | FC DordrechtFC Dordrecht |
| 16 Aug 21 | r02 | Jong PSVJong PSV | 0 - 1 | FC Den BoschFC Den Bosch |
| |
| 20 Aug 21 | r03 | ADO Den HaagADO Den Haag | 1 - 2 | FC EmmenFC Emmen |
| 20 Aug 21 | r03 | FC Den BoschFC Den Bosch | 2 - 3 | Jong AjaxJong Ajax |
| 20 Aug 21 | r03 | FC DordrechtFC Dordrecht | 2 - 2 | Jong UtrechtJong Utrecht |
| 20 Aug 21 | r03 | ExcelsiorExcelsior | 1 - 1 | FC VolendamFC Volendam |
| 20 Aug 21 | r03 | De GraafschapDe Graafschap | 2 - 0 | NAC BredaNAC Breda |
| 20 Aug 21 | r03 | MVV MaastrichtMVV Maastrich | 3 - 2 | Helmond SportHelmond Sport |
| 20 Aug 21 | r03 | SC TelstarSC Telstar | 3 - 4 | Roda JCRoda JC |
| 21 Aug 21 | r03 | VVV-VenloVVV-Venlo | 2 - 1 | Almere City FCAlmere City F |
| 23 Aug 21 | r03 | Jong AZJong AZ | 1 - 0 | TOP OssTOP Oss |
| 23 Aug 21 | r03 | Jong PSVJong PSV | 3 - 2 | FC EindhovenFC Eindhoven |
| |
| 27 Aug 21 | r04 | Jong AjaxJong Ajax | 1 - 2 | ExcelsiorExcelsior |
| 27 Aug 21 | r04 | FC EindhovenFC Eindhoven | 1 - 0 | FC Den BoschFC Den Bosch |
| 27 Aug 21 | r04 | FC EmmenFC Emmen | 0 - 2 | De GraafschapDe Graafschap |
| 27 Aug 21 | r04 | NAC BredaNAC Breda | 3 - 0 | ADO Den HaagADO Den Haag |
| 27 Aug 21 | r04 | Roda JCRoda JC | 3 - 4 | Almere City FCAlmere City F |
| 27 Aug 21 | r04 | Jong UtrechtJong Utrecht | 3 - 0 | SC TelstarSC Telstar |
| 27 Aug 21 | r04 | FC VolendamFC Volendam | 5 - 0 | MVV MaastrichtMVV Maastrich |
| 27 Aug 21 | r04 | VVV-VenloVVV-Venlo | 0 - 1 | Jong AZJong AZ |
| 27 Aug 21 | r04 | Helmond SportHelmond Sport | 1 - 0 | Jong PSVJong PSV |
| 28 Aug 21 | r04 | TOP OssTOP Oss | 3 - 0 | FC DordrechtFC Dordrecht |
| |
| 03 Sep 21 | r05 | FC Den BoschFC Den Bosch | 0 - 5 | ExcelsiorExcelsior |
| 03 Sep 21 | r05 | Helmond SportHelmond Sport | 1 - 0 | FC EmmenFC Emmen |
| 04 Sep 21 | r05 | Almere City FCAlmere City F | 3 - 0 | TOP OssTOP Oss |
| 05 Sep 21 | r05 | MVV MaastrichtMVV Maastrich | 3 - 0 | SC TelstarSC Telstar |
| 05 Sep 21 | r05 | ADO Den HaagADO Den Haag | 4 - 2 | FC EindhovenFC Eindhoven |
| 05 Sep 21 | r05 | FC DordrechtFC Dordrecht | 0 - 1 | VVV-VenloVVV-Venlo |
| |
| 10 Sep 21 | r06 | FC EmmenFC Emmen | 7 - 1 | MVV MaastrichtMVV Maastrich |
| 10 Sep 21 | r06 | ExcelsiorExcelsior | 3 - 1 | FC DordrechtFC Dordrecht |
| 10 Sep 21 | r06 | TOP OssTOP Oss | 3 - 3 | ADO Den HaagADO Den Haag |
| 10 Sep 21 | r06 | SC TelstarSC Telstar | 1 - 1 | Almere City FCAlmere City F |
| 10 Sep 21 | r06 | VVV-VenloVVV-Venlo | 2 - 1 | FC Den BoschFC Den Bosch |
| 10 Sep 21 | r06 | Jong AZJong AZ | 0 - 1 | Jong UtrechtJong Utrecht |
| 10 Sep 21 | r06 | De GraafschapDe Graafschap | 0 - 3 | FC VolendamFC Volendam |
| 10 Sep 21 | r06 | Jong PSVJong PSV | 3 - 1 | Jong AjaxJong Ajax |
| 10 Sep 21 | r06 | Roda JCRoda JC | 0 - 0 | NAC BredaNAC Breda |
| |
| 13 Sep 21 | r05 | Jong AjaxJong Ajax | 6 - 3 | NAC BredaNAC Breda |
| 13 Sep 21 | r05 | Jong AZJong AZ | 2 - 1 | De GraafschapDe Graafschap |
| 13 Sep 21 | r05 | Jong UtrechtJong Utrecht | 2 - 1 | Jong PSVJong PSV |
| 13 Sep 21 | r05 | FC VolendamFC Volendam | 2 - 2 | Roda JCRoda JC |
| |
| 13 Sep 21 | r06 | FC EindhovenFC Eindhoven | 3 - 2 | Helmond SportHelmond Sport |
| |
| 17 Sep 21 | r07 | Almere City FCAlmere City F | 2 - 4 | Jong AjaxJong Ajax |
| 17 Sep 21 | r07 | FC Den BoschFC Den Bosch | 2 - 1 | Jong AZJong AZ |
| 17 Sep 21 | r07 | FC DordrechtFC Dordrecht | 0 - 1 | SC TelstarSC Telstar |
| 17 Sep 21 | r07 | De GraafschapDe Graafschap | 3 - 1 | ExcelsiorExcelsior |
| 17 Sep 21 | r07 | Helmond SportHelmond Sport | 0 - 3 | Jong UtrechtJong Utrecht |
| 17 Sep 21 | r07 | MVV MaastrichtMVV Maastrich | 1 - 0 | FC EindhovenFC Eindhoven |
| 17 Sep 21 | r07 | NAC BredaNAC Breda | 1 - 2 | FC EmmenFC Emmen |
| 17 Sep 21 | r07 | Roda JCRoda JC | 2 - 0 | TOP OssTOP Oss |
| 17 Sep 21 | r07 | FC VolendamFC Volendam | 2 - 1 | VVV-VenloVVV-Venlo |
| 20 Sep 21 | r07 | Jong PSVJong PSV | 0 - 1 | ADO Den HaagADO Den Haag |
| |
| 24 Sep 21 | r08 | ADO Den HaagADO Den Haag | 2 - 0 | Roda JCRoda JC |
| 24 Sep 21 | r08 | Almere City FCAlmere City F | 2 - 2 | FC DordrechtFC Dordrecht |
| 24 Sep 21 | r08 | FC EindhovenFC Eindhoven | 2 - 0 | NAC BredaNAC Breda |
| 24 Sep 21 | r08 | FC EmmenFC Emmen | 2 - 0 | FC Den BoschFC Den Bosch |
| 24 Sep 21 | r08 | ExcelsiorExcelsior | 3 - 0 | Jong PSVJong PSV |
| 24 Sep 21 | r08 | De GraafschapDe Graafschap | 2 - 2 | Jong UtrechtJong Utrecht |
| 24 Sep 21 | r08 | TOP OssTOP Oss | 2 - 3 | FC VolendamFC Volendam |
| 24 Sep 21 | r08 | SC TelstarSC Telstar | 1 - 0 | Jong AZJong AZ |
| 24 Sep 21 | r08 | VVV-VenloVVV-Venlo | 1 - 0 | Helmond SportHelmond Sport |
| 27 Sep 21 | r08 | Jong AjaxJong Ajax | 3 - 1 | MVV MaastrichtMVV Maastrich |
| |
| 01 Oct 21 | r09 | Jong AZJong AZ | 2 - 1 | FC DordrechtFC Dordrecht |
| 01 Oct 21 | r09 | FC Den BoschFC Den Bosch | 0 - 1 | SC TelstarSC Telstar |
| 01 Oct 21 | r09 | Helmond SportHelmond Sport | 3 - 1 | Jong AjaxJong Ajax |
| 01 Oct 21 | r09 | MVV MaastrichtMVV Maastrich | 2 - 6 | ADO Den HaagADO Den Haag |
| 01 Oct 21 | r09 | NAC BredaNAC Breda | 4 - 1 | ExcelsiorExcelsior |
| 01 Oct 21 | r09 | TOP OssTOP Oss | 0 - 3 | De GraafschapDe Graafschap |
| 01 Oct 21 | r09 | Jong PSVJong PSV | 2 - 1 | VVV-VenloVVV-Venlo |
| 01 Oct 21 | r09 | Roda JCRoda JC | 2 - 0 | FC EindhovenFC Eindhoven |
| 01 Oct 21 | r09 | Jong UtrechtJong Utrecht | 0 - 1 | FC EmmenFC Emmen |
| 01 Oct 21 | r09 | FC VolendamFC Volendam | 3 - 2 | Almere City FCAlmere City F |
| |
| 09 Oct 21 | r10 | VVV-VenloVVV-Venlo | 2 - 0 | MVV MaastrichtMVV Maastrich |
| 09 Oct 21 | r10 | FC EmmenFC Emmen | 0 - 1 | ExcelsiorExcelsior |
| 09 Oct 21 | r10 | FC EindhovenFC Eindhoven | 2 - 1 | TOP OssTOP Oss |
| 10 Oct 21 | r10 | ADO Den HaagADO Den Haag | 3 - 2 | FC Den BoschFC Den Bosch |
| 10 Oct 21 | r10 | FC DordrechtFC Dordrecht | 0 - 1 | Helmond SportHelmond Sport |
| 10 Oct 21 | r10 | Almere City FCAlmere City F | 1 - 2 | De GraafschapDe Graafschap |
| |
| 15 Oct 21 | r11 | FC Den BoschFC Den Bosch | 1 - 0 | Almere City FCAlmere City F |
| 15 Oct 21 | r11 | ExcelsiorExcelsior | 3 - 0 | VVV-VenloVVV-Venlo |
| 15 Oct 21 | r11 | De GraafschapDe Graafschap | 0 - 0 | FC EindhovenFC Eindhoven |
| 15 Oct 21 | r11 | Helmond SportHelmond Sport | 0 - 0 | ADO Den HaagADO Den Haag |
| 15 Oct 21 | r11 | MVV MaastrichtMVV Maastrich | 2 - 1 | FC DordrechtFC Dordrecht |
| 15 Oct 21 | r11 | TOP OssTOP Oss | 1 - 2 | FC EmmenFC Emmen |
| 15 Oct 21 | r11 | Jong AjaxJong Ajax | 3 - 1 | Jong UtrechtJong Utrecht |
| 15 Oct 21 | r11 | NAC BredaNAC Breda | 1 - 0 | Jong AZJong AZ |
| 15 Oct 21 | r11 | Roda JCRoda JC | 2 - 2 | Jong PSVJong PSV |
| 15 Oct 21 | r11 | SC TelstarSC Telstar | 1 - 5 | FC VolendamFC Volendam |
| |
| 18 Oct 21 | r10 | Jong AZJong AZ | 1 - 1 | Jong AjaxJong Ajax |
| 18 Oct 21 | r10 | Jong PSVJong PSV | 2 - 3 | SC TelstarSC Telstar |
| 18 Oct 21 | r10 | Jong UtrechtJong Utrecht | 1 - 2 | Roda JCRoda JC |
| 18 Oct 21 | r10 | FC VolendamFC Volendam | 1 - 0 | NAC BredaNAC Breda |
| |
| 22 Oct 21 | r12 | ADO Den HaagADO Den Haag | 0 - 2 | ExcelsiorExcelsior |
| 22 Oct 21 | r12 | Almere City FCAlmere City F | 3 - 5 | Jong PSVJong PSV |
| 22 Oct 21 | r12 | Jong AZJong AZ | 0 - 1 | FC VolendamFC Volendam |
| 22 Oct 21 | r12 | FC DordrechtFC Dordrecht | 3 - 3 | FC Den BoschFC Den Bosch |
| 22 Oct 21 | r12 | FC EindhovenFC Eindhoven | 1 - 3 | Jong AjaxJong Ajax |
| 22 Oct 21 | r12 | NAC BredaNAC Breda | 3 - 0 | MVV MaastrichtMVV Maastrich |
| 22 Oct 21 | r12 | SC TelstarSC Telstar | 2 - 2 | Helmond SportHelmond Sport |
| 22 Oct 21 | r12 | Jong UtrechtJong Utrecht | 2 - 1 | TOP OssTOP Oss |
| 22 Oct 21 | r12 | VVV-VenloVVV-Venlo | 1 - 2 | De GraafschapDe Graafschap |
| 23 Oct 21 | r12 | Roda JCRoda JC | 1 - 2 | FC EmmenFC Emmen |
| |
| 29 Oct 21 | r13 | FC Den BoschFC Den Bosch | 2 - 1 | Jong UtrechtJong Utrecht |
| 29 Oct 21 | r13 | FC EmmenFC Emmen | 1 - 0 | VVV-VenloVVV-Venlo |
| 29 Oct 21 | r13 | De GraafschapDe Graafschap | 1 - 0 | ADO Den HaagADO Den Haag |
| 29 Oct 21 | r13 | FC VolendamFC Volendam | 4 - 2 | FC DordrechtFC Dordrecht |
| 30 Oct 21 | r13 | ExcelsiorExcelsior | 3 - 4 | FC EindhovenFC Eindhoven |
| 30 Oct 21 | r13 | TOP OssTOP Oss | 1 - 3 | NAC BredaNAC Breda |
| 30 Oct 21 | r13 | TOP OssTOP Oss | 1 - 3 | NAC BredaNAC Breda |
| 01 Nov 21 | r13 | Helmond SportHelmond Sport | 1 - 2 | Almere City FCAlmere City F |
| 01 Nov 21 | r13 | Jong AjaxJong Ajax | 3 - 0 | SC TelstarSC Telstar |
| 01 Nov 21 | r13 | Jong PSVJong PSV | 2 - 0 | Jong AZJong AZ |
| |
| 05 Nov 21 | r14 | Jong AZJong AZ | 0 - 1 | MVV MaastrichtMVV Maastrich |
| 05 Nov 21 | r14 | FC Den BoschFC Den Bosch | 2 - 1 | De GraafschapDe Graafschap |
| 05 Nov 21 | r14 | FC DordrechtFC Dordrecht | 2 - 1 | NAC BredaNAC Breda |
| 05 Nov 21 | r14 | Jong PSVJong PSV | 2 - 2 | TOP OssTOP Oss |
| 05 Nov 21 | r14 | Jong UtrechtJong Utrecht | 0 - 6 | FC EindhovenFC Eindhoven |
| 05 Nov 21 | r14 | FC VolendamFC Volendam | 2 - 2 | FC EmmenFC Emmen |
| 05 Nov 21 | r14 | VVV-VenloVVV-Venlo | 1 - 3 | Jong AjaxJong Ajax |
| 05 Nov 21 | r14 | Helmond SportHelmond Sport | 0 - 3 | Roda JCRoda JC |
| 06 Nov 21 | r14 | SC TelstarSC Telstar | 2 - 5 | ExcelsiorExcelsior |
| 07 Nov 21 | r14 | Almere City FCAlmere City F | 1 - 3 | ADO Den HaagADO Den Haag |
| |
| 12 Nov 21 | r15 | TOP OssTOP Oss | 0 - 0 | Helmond SportHelmond Sport |
| 13 Nov 21 | r15 | FC EindhovenFC Eindhoven | 5 - 1 | FC DordrechtFC Dordrecht |
| 14 Nov 21 | r15 | De GraafschapDe Graafschap | 1 - 1 | SC TelstarSC Telstar |
| 14 Nov 21 | r15 | ADO Den HaagADO Den Haag | 2 - 0 | VVV-VenloVVV-Venlo |
| 14 Nov 21 | r15 | ExcelsiorExcelsior | 4 - 4 | Almere City FCAlmere City F |
| |
| 15 Nov 21 | r20 | MVV MaastrichtMVV Maastrich | 0 - 1 | FC Den BoschFC Den Bosch |
| |
| 19 Nov 21 | r16 | Almere City FCAlmere City F | 0 - 2 | MVV MaastrichtMVV Maastrich |
| 19 Nov 21 | r16 | FC Den BoschFC Den Bosch | 1 - 0 | TOP OssTOP Oss |
| 19 Nov 21 | r16 | FC DordrechtFC Dordrecht | 0 - 4 | De GraafschapDe Graafschap |
| 19 Nov 21 | r16 | Helmond SportHelmond Sport | 1 - 5 | ExcelsiorExcelsior |
| 19 Nov 21 | r16 | SC TelstarSC Telstar | 0 - 2 | ADO Den HaagADO Den Haag |
| 19 Nov 21 | r16 | VVV-VenloVVV-Venlo | 2 - 0 | FC EindhovenFC Eindhoven |
| 19 Nov 21 | r16 | Jong AjaxJong Ajax | 4 - 4 | FC VolendamFC Volendam |
| 19 Nov 21 | r16 | FC EmmenFC Emmen | 2 - 0 | Jong PSVJong PSV |
| 19 Nov 21 | r16 | NAC BredaNAC Breda | 1 - 1 | Jong UtrechtJong Utrecht |
| 19 Nov 21 | r16 | Roda JCRoda JC | 2 - 2 | Jong AZJong AZ |
| |
| 22 Nov 21 | r15 | Jong AjaxJong Ajax | 2 - 1 | Roda JCRoda JC |
| 22 Nov 21 | r15 | Jong AZJong AZ | 0 - 0 | FC EmmenFC Emmen |
| 22 Nov 21 | r15 | Jong PSVJong PSV | 0 - 0 | NAC BredaNAC Breda |
| 22 Nov 21 | r15 | Jong UtrechtJong Utrecht | 0 - 1 | FC VolendamFC Volendam |
| |
| 26 Nov 21 | r17 | ADO Den HaagADO Den Haag | 5 - 1 | FC DordrechtFC Dordrecht |
| 26 Nov 21 | r17 | FC EindhovenFC Eindhoven | 1 - 0 | Jong AZJong AZ |
| 26 Nov 21 | r17 | ExcelsiorExcelsior | 2 - 1 | Jong UtrechtJong Utrecht |
| 26 Nov 21 | r17 | De GraafschapDe Graafschap | 1 - 3 | Jong AjaxJong Ajax |
| 26 Nov 21 | r17 | MVV MaastrichtMVV Maastrich | 1 - 2 | Jong PSVJong PSV |
| 26 Nov 21 | r17 | TOP OssTOP Oss | 1 - 1 | SC TelstarSC Telstar |
| 26 Nov 21 | r17 | Roda JCRoda JC | 0 - 0 | VVV-VenloVVV-Venlo |
| 26 Nov 21 | r17 | FC VolendamFC Volendam | 3 - 0 | FC Den BoschFC Den Bosch |
| 27 Nov 21 | r17 | NAC BredaNAC Breda | 1 - 0 | Helmond SportHelmond Sport |
| |
| 29 Nov 21 | r13 | MVV MaastrichtMVV Maastrich | 1 - 1 | Roda JCRoda JC |
| |
| 29 Nov 21 | r17 | FC EmmenFC Emmen | 3 - 0 | Almere City FCAlmere City F |
| |
| 03 Dec 21 | r18 | Almere City FCAlmere City F | 2 - 0 | FC EindhovenFC Eindhoven |
| 03 Dec 21 | r18 | FC Den BoschFC Den Bosch | 0 - 5 | NAC BredaNAC Breda |
| 03 Dec 21 | r18 | FC DordrechtFC Dordrecht | 2 - 5 | Roda JCRoda JC |
| 03 Dec 21 | r18 | Helmond SportHelmond Sport | 1 - 1 | FC VolendamFC Volendam |
| 03 Dec 21 | r18 | MVV MaastrichtMVV Maastrich | 1 - 1 | TOP OssTOP Oss |
| 03 Dec 21 | r18 | SC TelstarSC Telstar | 1 - 3 | VVV-VenloVVV-Venlo |
| 06 Dec 21 | r18 | Jong AjaxJong Ajax | 1 - 0 | FC EmmenFC Emmen |
| 06 Dec 21 | r18 | Jong AZJong AZ | 0 - 2 | ExcelsiorExcelsior |
| 06 Dec 21 | r18 | Jong PSVJong PSV | 2 - 3 | De GraafschapDe Graafschap |
| 06 Dec 21 | r18 | Jong UtrechtJong Utrecht | 1 - 4 | ADO Den HaagADO Den Haag |
| |
| 10 Dec 21 | r19 | ADO Den HaagADO Den Haag | 3 - 2 | Jong AZJong AZ |
| 10 Dec 21 | r19 | FC EindhovenFC Eindhoven | 1 - 1 | SC TelstarSC Telstar |
| 10 Dec 21 | r19 | FC EmmenFC Emmen | 2 - 1 | FC DordrechtFC Dordrecht |
| 10 Dec 21 | r19 | ExcelsiorExcelsior | 2 - 1 | MVV MaastrichtMVV Maastrich |
| 10 Dec 21 | r19 | De GraafschapDe Graafschap | 0 - 1 | Helmond SportHelmond Sport |
| 10 Dec 21 | r19 | NAC BredaNAC Breda | 1 - 1 | Almere City FCAlmere City F |
| 10 Dec 21 | r19 | TOP OssTOP Oss | 1 - 1 | Jong AjaxJong Ajax |
| 10 Dec 21 | r19 | Roda JCRoda JC | 3 - 2 | FC Den BoschFC Den Bosch |
| 10 Dec 21 | r19 | FC VolendamFC Volendam | 3 - 2 | Jong PSVJong PSV |
| 10 Dec 21 | r19 | VVV-VenloVVV-Venlo | 1 - 2 | Jong UtrechtJong Utrecht |
| |
| 17 Dec 21 | r20 | ADO Den HaagADO Den Haag | 4 - 1 | NAC BredaNAC Breda |
| 17 Dec 21 | r20 | SC TelstarSC Telstar | 0 - 0 | Jong PSVJong PSV |
| 17 Dec 21 | r20 | VVV-VenloVVV-Venlo | 2 - 3 | TOP OssTOP Oss |
| 17 Dec 21 | r20 | MVV MaastrichtMVV Maastrich | 0 - 1 | FC EmmenFC Emmen |
| 17 Dec 21 | r20 | Almere City FCAlmere City F | 2 - 3 | FC VolendamFC Volendam |
| 18 Dec 21 | r20 | FC EindhovenFC Eindhoven | 1 - 1 | Roda JCRoda JC |
| 18 Dec 21 | r20 | FC DordrechtFC Dordrecht | 1 - 1 | ExcelsiorExcelsior |
| 20 Dec 21 | r20 | Jong AjaxJong Ajax | 1 - 1 | Helmond SportHelmond Sport |
| 20 Dec 21 | r20 | Jong AZJong AZ | 3 - 3 | FC Den BoschFC Den Bosch |
| 20 Dec 21 | r20 | Jong UtrechtJong Utrecht | 0 - 2 | De GraafschapDe Graafschap |
| |
| 07 Jan 22 | r21 | Helmond SportHelmond Sport | 1 - 2 | FC DordrechtFC Dordrecht |
| 07 Jan 22 | r21 | Roda JCRoda JC | 1 - 0 | MVV MaastrichtMVV Maastrich |
| 08 Jan 22 | r21 | FC Den BoschFC Den Bosch | 0 - 2 | FC EmmenFC Emmen |
| 08 Jan 22 | r21 | NAC BredaNAC Breda | 0 - 0 | FC EindhovenFC Eindhoven |
| 09 Jan 22 | r21 | FC VolendamFC Volendam | 2 - 1 | SC TelstarSC Telstar |
| 09 Jan 22 | r21 | De GraafschapDe Graafschap | 1 - 2 | VVV-VenloVVV-Venlo |
| 10 Jan 22 | r21 | Jong UtrechtJong Utrecht | 0 - 2 | Jong AjaxJong Ajax |
| 10 Jan 22 | r21 | Jong PSVJong PSV | 5 - 1 | Almere City FCAlmere City F |
| |
| 14 Jan 22 | r22 | Almere City FCAlmere City F | 0 - 4 | Roda JCRoda JC |
| 14 Jan 22 | r22 | FC EindhovenFC Eindhoven | 4 - 0 | Jong UtrechtJong Utrecht |
| 14 Jan 22 | r22 | ExcelsiorExcelsior | 0 - 0 | De GraafschapDe Graafschap |
| 14 Jan 22 | r22 | NAC BredaNAC Breda | 0 - 0 | FC VolendamFC Volendam |
| 14 Jan 22 | r22 | SC TelstarSC Telstar | 2 - 1 | MVV MaastrichtMVV Maastrich |
| 14 Jan 22 | r22 | VVV-VenloVVV-Venlo | 1 - 4 | Jong PSVJong PSV |
| 15 Jan 22 | r22 | ADO Den HaagADO Den Haag | 2 - 0 | TOP OssTOP Oss |
| 17 Jan 22 | r22 | FC DordrechtFC Dordrecht | 2 - 0 | Jong AZJong AZ |
| 17 Jan 22 | r22 | Jong AjaxJong Ajax | 2 - 1 | FC Den BoschFC Den Bosch |
| |
| 21 Jan 22 | r23 | Jong AZJong AZ | 2 - 0 | VVV-VenloVVV-Venlo |
| 21 Jan 22 | r23 | FC Den BoschFC Den Bosch | 0 - 2 | FC EindhovenFC Eindhoven |
| 21 Jan 22 | r23 | De GraafschapDe Graafschap | 1 - 0 | Almere City FCAlmere City F |
| 21 Jan 22 | r23 | Helmond SportHelmond Sport | 1 - 3 | TOP OssTOP Oss |
| 21 Jan 22 | r23 | MVV MaastrichtMVV Maastrich | 0 - 1 | FC VolendamFC Volendam |
| 21 Jan 22 | r23 | Jong PSVJong PSV | 3 - 0 | ExcelsiorExcelsior |
| 21 Jan 22 | r23 | Roda JCRoda JC | 5 - 0 | ADO Den HaagADO Den Haag |
| 21 Jan 22 | r23 | Jong UtrechtJong Utrecht | 0 - 4 | FC DordrechtFC Dordrecht |
| 22 Jan 22 | r23 | FC EmmenFC Emmen | 2 - 0 | NAC BredaNAC Breda |
| 23 Jan 22 | r23 | SC TelstarSC Telstar | 1 - 0 | Jong AjaxJong Ajax |
| |
| 24 Jan 22 | r21 | TOP OssTOP Oss | 1 - 0 | Jong AZJong AZ |
| 25 Jan 22 | r21 | ExcelsiorExcelsior | 2 - 3 | ADO Den HaagADO Den Haag |
| |
| 28 Jan 22 | r24 | TOP OssTOP Oss | 2 - 1 | FC Den BoschFC Den Bosch |
| 29 Jan 22 | r24 | ExcelsiorExcelsior | 0 - 1 | FC EmmenFC Emmen |
| 29 Jan 22 | r24 | FC EindhovenFC Eindhoven | 1 - 0 | MVV MaastrichtMVV Maastrich |
| 30 Jan 22 | r24 | VVV-VenloVVV-Venlo | 4 - 2 | FC DordrechtFC Dordrecht |
| 30 Jan 22 | r24 | Almere City FCAlmere City F | 0 - 0 | SC TelstarSC Telstar |
| 30 Jan 22 | r24 | ADO Den HaagADO Den Haag | 0 - 0 | De GraafschapDe Graafschap |
| |
| 04 Feb 22 | r25 | FC DordrechtFC Dordrecht | 2 - 2 | Almere City FCAlmere City F |
| 04 Feb 22 | r25 | FC EmmenFC Emmen | 3 - 1 | TOP OssTOP Oss |
| 04 Feb 22 | r25 | MVV MaastrichtMVV Maastrich | 0 - 5 | VVV-VenloVVV-Venlo |
| 04 Feb 22 | r25 | SC TelstarSC Telstar | 0 - 3 | De GraafschapDe Graafschap |
| 04 Feb 22 | r25 | Jong AjaxJong Ajax | 2 - 1 | Jong AZJong AZ |
| 04 Feb 22 | r25 | NAC BredaNAC Breda | 2 - 2 | Roda JCRoda JC |
| 04 Feb 22 | r25 | Jong PSVJong PSV | 2 - 0 | Helmond SportHelmond Sport |
| 04 Feb 22 | r25 | FC VolendamFC Volendam | 2 - 0 | Jong UtrechtJong Utrecht |
| 06 Feb 22 | r25 | FC Den BoschFC Den Bosch | 0 - 1 | ADO Den HaagADO Den Haag |
| 07 Feb 22 | r25 | FC EindhovenFC Eindhoven | 4 - 1 | ExcelsiorExcelsior |
| |
| 07 Feb 22 | r24 | Jong AjaxJong Ajax | 2 - 0 | Jong PSVJong PSV |
| 07 Feb 22 | r24 | Roda JCRoda JC | 1 - 1 | FC VolendamFC Volendam |
| 07 Feb 22 | r24 | Jong UtrechtJong Utrecht | 3 - 2 | Helmond SportHelmond Sport |
| |
| 11 Feb 22 | r26 | ADO Den HaagADO Den Haag | 2 - 3 | MVV MaastrichtMVV Maastrich |
| 11 Feb 22 | r26 | Almere City FCAlmere City F | 0 - 0 | FC EmmenFC Emmen |
| 11 Feb 22 | r26 | ExcelsiorExcelsior | 6 - 2 | Jong AjaxJong Ajax |
| 11 Feb 22 | r26 | De GraafschapDe Graafschap | 2 - 2 | FC DordrechtFC Dordrecht |
| 11 Feb 22 | r26 | Helmond SportHelmond Sport | 2 - 2 | SC TelstarSC Telstar |
| 11 Feb 22 | r26 | TOP OssTOP Oss | 1 - 2 | FC EindhovenFC Eindhoven |
| 11 Feb 22 | r26 | FC VolendamFC Volendam | 2 - 1 | Jong AZJong AZ |
| 13 Feb 22 | r26 | NAC BredaNAC Breda | 2 - 0 | FC Den BoschFC Den Bosch |
| 13 Feb 22 | r26 | VVV-VenloVVV-Venlo | 1 - 1 | Roda JCRoda JC |
| 14 Feb 22 | r26 | Jong PSVJong PSV | 0 - 2 | Jong UtrechtJong Utrecht |
| |
| 21 Feb 22 | r24 | Jong AZJong AZ | 0 - 2 | NAC BredaNAC Breda |
| |
| 21 Feb 22 | r27 | Jong AjaxJong Ajax | 1 - 3 | Almere City FCAlmere City F |
| 21 Feb 22 | r27 | Jong UtrechtJong Utrecht | 0 - 1 | ExcelsiorExcelsior |
| |
| 25 Feb 22 | r28 | Almere City FCAlmere City F | 0 - 1 | VVV-VenloVVV-Venlo |
| 25 Feb 22 | r28 | Jong AZJong AZ | 1 - 3 | FC EindhovenFC Eindhoven |
| 25 Feb 22 | r28 | FC DordrechtFC Dordrecht | 3 - 1 | MVV MaastrichtMVV Maastrich |
| 25 Feb 22 | r28 | FC EmmenFC Emmen | 2 - 1 | Jong AjaxJong Ajax |
| 25 Feb 22 | r28 | ExcelsiorExcelsior | 2 - 0 | Roda JCRoda JC |
| 25 Feb 22 | r28 | De GraafschapDe Graafschap | 0 - 0 | FC Den BoschFC Den Bosch |
| 25 Feb 22 | r28 | NAC BredaNAC Breda | 3 - 1 | Jong PSVJong PSV |
| 25 Feb 22 | r28 | TOP OssTOP Oss | 4 - 1 | Jong UtrechtJong Utrecht |
| 25 Feb 22 | r28 | FC VolendamFC Volendam | 4 - 1 | Helmond SportHelmond Sport |
| |
| 01 Mar 22 | r22 | FC EmmenFC Emmen | 1 - 2 | Helmond SportHelmond Sport |
| |
| 04 Mar 22 | r29 | ExcelsiorExcelsior | 4 - 0 | FC Den BoschFC Den Bosch |
| 04 Mar 22 | r29 | De GraafschapDe Graafschap | 0 - 0 | Jong AZJong AZ |
| 04 Mar 22 | r29 | Helmond SportHelmond Sport | 1 - 2 | FC EindhovenFC Eindhoven |
| 04 Mar 22 | r29 | MVV MaastrichtMVV Maastrich | 1 - 2 | NAC BredaNAC Breda |
| 04 Mar 22 | r29 | Roda JCRoda JC | 4 - 0 | FC DordrechtFC Dordrecht |
| 04 Mar 22 | r29 | SC TelstarSC Telstar | 2 - 2 | TOP OssTOP Oss |
| 04 Mar 22 | r29 | VVV-VenloVVV-Venlo | 0 - 0 | FC VolendamFC Volendam |
| 07 Mar 22 | r29 | Jong AjaxJong Ajax | 6 - 3 | ADO Den HaagADO Den Haag |
| 07 Mar 22 | r29 | Jong PSVJong PSV | 1 - 3 | FC EmmenFC Emmen |
| 07 Mar 22 | r29 | Jong UtrechtJong Utrecht | 1 - 2 | Almere City FCAlmere City F |
| |
| 07 Mar 22 | r30 | Jong AZJong AZ | 3 - 2 | SC TelstarSC Telstar |
| 11 Mar 22 | r30 | Almere City FCAlmere City F | 3 - 0 | Helmond SportHelmond Sport |
| 11 Mar 22 | r30 | FC Den BoschFC Den Bosch | 3 - 1 | MVV MaastrichtMVV Maastrich |
| 11 Mar 22 | r30 | FC DordrechtFC Dordrecht | 3 - 3 | Jong AjaxJong Ajax |
| 11 Mar 22 | r30 | FC EindhovenFC Eindhoven | 4 - 0 | VVV-VenloVVV-Venlo |
| 11 Mar 22 | r30 | FC EmmenFC Emmen | 2 - 0 | Jong UtrechtJong Utrecht |
| 11 Mar 22 | r30 | NAC BredaNAC Breda | 2 - 0 | De GraafschapDe Graafschap |
| 11 Mar 22 | r30 | TOP OssTOP Oss | 1 - 2 | Roda JCRoda JC |
| 11 Mar 22 | r30 | FC VolendamFC Volendam | 2 - 5 | ExcelsiorExcelsior |
| |
| 14 Mar 22 | r27 | FC Den BoschFC Den Bosch | 3 - 2 | Jong PSVJong PSV |
| 14 Mar 22 | r27 | FC DordrechtFC Dordrecht | 1 - 0 | TOP OssTOP Oss |
| 14 Mar 22 | r27 | FC EmmenFC Emmen | 4 - 1 | FC VolendamFC Volendam |
| 14 Mar 22 | r27 | FC EindhovenFC Eindhoven | 1 - 1 | ADO Den HaagADO Den Haag |
| 14 Mar 22 | r27 | MVV MaastrichtMVV Maastrich | 2 - 3 | Jong AZJong AZ |
| 14 Mar 22 | r27 | Roda JCRoda JC | 2 - 0 | De GraafschapDe Graafschap |
| 14 Mar 22 | r27 | SC TelstarSC Telstar | 1 - 4 | NAC BredaNAC Breda |
| 14 Mar 22 | r27 | Helmond SportHelmond Sport | 0 - 3 | VVV-VenloVVV-Venlo |
| |
| 18 Mar 22 | r31 | ADO Den HaagADO Den Haag | 1 - 1 | FC VolendamFC Volendam |
| 18 Mar 22 | r31 | Jong AjaxJong Ajax | 2 - 2 | FC EindhovenFC Eindhoven |
| 18 Mar 22 | r31 | Almere City FCAlmere City F | 2 - 0 | FC Den BoschFC Den Bosch |
| 18 Mar 22 | r31 | De GraafschapDe Graafschap | 1 - 3 | MVV MaastrichtMVV Maastrich |
| 18 Mar 22 | r31 | Helmond SportHelmond Sport | 4 - 0 | NAC BredaNAC Breda |
| 18 Mar 22 | r31 | TOP OssTOP Oss | 1 - 1 | ExcelsiorExcelsior |
| 18 Mar 22 | r31 | SC TelstarSC Telstar | 1 - 0 | FC DordrechtFC Dordrecht |
| 18 Mar 22 | r31 | Jong UtrechtJong Utrecht | 0 - 1 | Jong AZJong AZ |
| 18 Mar 22 | r31 | Jong PSVJong PSV | 3 - 3 | Roda JCRoda JC |
| 19 Mar 22 | r31 | VVV-VenloVVV-Venlo | 0 - 2 | FC EmmenFC Emmen |
| |
| 21 Mar 22 | r28 | ADO Den HaagADO Den Haag | 2 - 1 | SC TelstarSC Telstar |
| |
| 25 Mar 22 | r32 | FC DordrechtFC Dordrecht | 3 - 1 | ADO Den HaagADO Den Haag |
| 25 Mar 22 | r32 | FC EindhovenFC Eindhoven | 1 - 2 | De GraafschapDe Graafschap |
| 26 Mar 22 | r32 | FC Den BoschFC Den Bosch | 0 - 0 | VVV-VenloVVV-Venlo |
| 26 Mar 22 | r32 | ExcelsiorExcelsior | 3 - 0 | Helmond SportHelmond Sport |
| 27 Mar 22 | r32 | MVV MaastrichtMVV Maastrich | 0 - 3 | Almere City FCAlmere City F |
| 27 Mar 22 | r32 | FC EmmenFC Emmen | 2 - 1 | SC TelstarSC Telstar |
| |
| 01 Apr 22 | r33 | Almere City FCAlmere City F | 3 - 0 | ExcelsiorExcelsior |
| 01 Apr 22 | r33 | FC DordrechtFC Dordrecht | 0 - 1 | FC EindhovenFC Eindhoven |
| 01 Apr 22 | r33 | De GraafschapDe Graafschap | 1 - 1 | FC EmmenFC Emmen |
| 01 Apr 22 | r33 | Helmond SportHelmond Sport | 1 - 2 | MVV MaastrichtMVV Maastrich |
| 01 Apr 22 | r33 | SC TelstarSC Telstar | 1 - 2 | FC Den BoschFC Den Bosch |
| 01 Apr 22 | r33 | VVV-VenloVVV-Venlo | 0 - 5 | ADO Den HaagADO Den Haag |
| 01 Apr 22 | r33 | Jong AZJong AZ | 2 - 0 | Jong PSVJong PSV |
| 01 Apr 22 | r33 | NAC BredaNAC Breda | 0 - 0 | Jong AjaxJong Ajax |
| 01 Apr 22 | r33 | Roda JCRoda JC | 2 - 1 | Jong UtrechtJong Utrecht |
| 01 Apr 22 | r33 | FC VolendamFC Volendam | 1 - 2 | TOP OssTOP Oss |
| |
| 04 Apr 22 | r32 | Jong AjaxJong Ajax | 4 - 1 | TOP OssTOP Oss |
| 04 Apr 22 | r32 | Jong AZJong AZ | 0 - 1 | Roda JCRoda JC |
| 04 Apr 22 | r32 | Jong PSVJong PSV | 2 - 2 | FC VolendamFC Volendam |
| 04 Apr 22 | r32 | Jong UtrechtJong Utrecht | 1 - 0 | NAC BredaNAC Breda |
| |
| 08 Apr 22 | r34 | ADO Den HaagADO Den Haag | 2 - 1 | Helmond SportHelmond Sport |
| 08 Apr 22 | r34 | FC Den BoschFC Den Bosch | 3 - 0 | FC DordrechtFC Dordrecht |
| 08 Apr 22 | r34 | FC EindhovenFC Eindhoven | 3 - 1 | Almere City FCAlmere City F |
| 08 Apr 22 | r34 | FC EmmenFC Emmen | 3 - 0 | Jong AZJong AZ |
| 08 Apr 22 | r34 | ExcelsiorExcelsior | 1 - 4 | SC TelstarSC Telstar |
| 08 Apr 22 | r34 | MVV MaastrichtMVV Maastrich | 2 - 4 | Jong UtrechtJong Utrecht |
| 08 Apr 22 | r34 | NAC BredaNAC Breda | 3 - 1 | VVV-VenloVVV-Venlo |
| 08 Apr 22 | r34 | TOP OssTOP Oss | 2 - 0 | Jong PSVJong PSV |
| 08 Apr 22 | r34 | Roda JCRoda JC | 2 - 2 | Jong AjaxJong Ajax |
| 08 Apr 22 | r34 | FC VolendamFC Volendam | 3 - 1 | De GraafschapDe Graafschap |
| |
| 15 Apr 22 | r35 | FC DordrechtFC Dordrecht | 0 - 1 | FC EmmenFC Emmen |
| 15 Apr 22 | r35 | FC EindhovenFC Eindhoven | 1 - 3 | Jong PSVJong PSV |
| 15 Apr 22 | r35 | De GraafschapDe Graafschap | 1 - 2 | TOP OssTOP Oss |
| 15 Apr 22 | r35 | MVV MaastrichtMVV Maastrich | 1 - 1 | ExcelsiorExcelsior |
| 15 Apr 22 | r35 | Roda JCRoda JC | 5 - 3 | Helmond SportHelmond Sport |
| 15 Apr 22 | r35 | VVV-VenloVVV-Venlo | 3 - 2 | SC TelstarSC Telstar |
| 15 Apr 22 | r35 | Jong AZJong AZ | 0 - 1 | ADO Den HaagADO Den Haag |
| 16 Apr 22 | r35 | FC VolendamFC Volendam | 3 - 1 | Jong AjaxJong Ajax |
| 16 Apr 22 | r35 | Almere City FCAlmere City F | 1 - 2 | NAC BredaNAC Breda |
| 18 Apr 22 | r35 | Jong UtrechtJong Utrecht | 0 - 1 | FC Den BoschFC Den Bosch |
| |
| 19 Apr 22 | r30 | ADO Den HaagADO Den Haag | 2 - 2 | Jong PSVJong PSV |
| |
| 22 Apr 22 | r36 | FC Den BoschFC Den Bosch | 1 - 2 | FC VolendamFC Volendam |
| 22 Apr 22 | r36 | FC EmmenFC Emmen | 2 - 0 | Roda JCRoda JC |
| 22 Apr 22 | r36 | ExcelsiorExcelsior | 3 - 3 | Jong AZJong AZ |
| 22 Apr 22 | r36 | Helmond SportHelmond Sport | 0 - 4 | De GraafschapDe Graafschap |
| 22 Apr 22 | r36 | NAC BredaNAC Breda | 1 - 2 | FC DordrechtFC Dordrecht |
| 22 Apr 22 | r36 | TOP OssTOP Oss | 2 - 3 | Almere City FCAlmere City F |
| 22 Apr 22 | r36 | SC TelstarSC Telstar | 0 - 1 | FC EindhovenFC Eindhoven |
| 24 Apr 22 | r36 | ADO Den HaagADO Den Haag | 1 - 1 | Jong UtrechtJong Utrecht |
| 25 Apr 22 | r36  | Jong AjaxJong Ajax | 6 - 1 | VVV-VenloVVV-Venlo |
| 25 Apr 22 | r36 | Jong PSVJong PSV | 2 - 2 | MVV MaastrichtMVV Maastrich |
| |
| 29 Apr 22 | r37 | ADO Den HaagADO Den Haag | 1 - 0 | Almere City FCAlmere City F |
| 29 Apr 22 | r37 | Jong AZJong AZ | 0 - 1 | Helmond SportHelmond Sport |
| 29 Apr 22 | r37 | FC Den BoschFC Den Bosch | 1 - 0 | Roda JCRoda JC |
| 29 Apr 22 | r37 | FC DordrechtFC Dordrecht | 3 - 2 | FC VolendamFC Volendam |
| 29 Apr 22 | r37 | FC EindhovenFC Eindhoven | 1 - 0 | FC EmmenFC Emmen |
| 29 Apr 22 | r37 | De GraafschapDe Graafschap | 1 - 1 | Jong PSVJong PSV |
| 29 Apr 22 | r37 | MVV MaastrichtMVV Maastrich | 1 - 0 | Jong AjaxJong Ajax |
| 29 Apr 22 | r37 | NAC BredaNAC Breda | 3 - 0 | TOP OssTOP Oss |
| 29 Apr 22 | r37 | SC TelstarSC Telstar | 1 - 3 | Jong UtrechtJong Utrecht |
| 29 Apr 22 | r37 | VVV-VenloVVV-Venlo | 2 - 2 | ExcelsiorExcelsior |
| |
| 06 May 22 | r38 | Jong AjaxJong Ajax | 1 - 1 | De GraafschapDe Graafschap |
| 06 May 22 | r38 | Almere City FCAlmere City F | 0 - 3 | Jong AZJong AZ |
| 06 May 22 | r38 | FC EmmenFC Emmen | 3 - 0 | ADO Den HaagADO Den Haag |
| 06 May 22 | r38 | ExcelsiorExcelsior | 2 - 2 | NAC BredaNAC Breda |
| 06 May 22 | r38 | Helmond SportHelmond Sport | 1 - 1 | FC Den BoschFC Den Bosch |
| 06 May 22 | r38 | TOP OssTOP Oss | 0 - 1 | MVV MaastrichtMVV Maastrich |
| 06 May 22 | r38 | Jong PSVJong PSV | 1 - 1 | FC DordrechtFC Dordrecht |
| 06 May 22 | r38 | Roda JCRoda JC | 4 - 3 | SC TelstarSC Telstar |
| 06 May 22 | r38 | Jong UtrechtJong Utrecht | 2 - 3 | VVV-VenloVVV-Venlo |
| 06 May 22 | r38 | FC VolendamFC Volendam | 2 - 2 | FC EindhovenFC Eindhoven |
Team 2021-2022 Schedules
Almere City
De Graafschap
Den Bosch
Dordrecht
FC Eindhoven
FC Emmen
Helmond Sport
Heracles Almelo
Jong Ajax
Jong AZ
Jong PSV
Jong Utrecht
MVV Maastricht
NAC Breda
RKC Waalwijk
Roda JC
TOP Oss
Vitesse
Volendam
VVV-Venlo
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