| 24 Jul 21 | r01    | PardubicePardubice | 2 - 2 | KarvinaKarvina |
| |
| 31 Jul 21 | r02 | Sigma OlomoucSigma Olomouc | 3 - 2 | PardubicePardubice |
| |
| 08 Aug 21 | r03  | PardubicePardubice | 1 - 1 | Mlada BoleslavMlada Bolesla |
| |
| 15 Aug 21 | r04 | Banik OstravaBanik Ostrava | 3 - 1 | PardubicePardubice |
| |
| 21 Aug 21 | r05 | PardubicePardubice | 3 - 0 | Bohemians 1905Bohemians 190 |
| |
| 28 Aug 21 | r06 | SlovackoSlovacko | 2 - 1 | PardubicePardubice |
| |
| 11 Sep 21 | r07 | PardubicePardubice | 2 - 2 | LiberecLiberec |
| |
| 17 Sep 21 | r08 | Hradec KrálovéHradec Králov | 2 - 0 | PardubicePardubice |
| |
| 25 Sep 21 | r09 | PardubicePardubice | 0 - 1 | Viktoria PlzenViktoria Plze |
| |
| 02 Oct 21 | r10 | Dynamo České BudějoviceDynamo České | 3 - 1 | PardubicePardubice |
| |
| 17 Oct 21 | r11 | PardubicePardubice | 2 - 4 | Sparta PragueSparta Prague |
| |
| 23 Oct 21 | r12 | PardubicePardubice | 0 - 0 | ZlínZlín |
| |
| 31 Oct 21 | r13 | JablonecJablonec | 1 - 1 | PardubicePardubice |
| |
| 07 Nov 21 | r14 | PardubicePardubice | 0 - 5 | Slavia PragueSlavia Prague |
| |
| 21 Nov 21 | r15 | TepliceTeplice | 1 - 2 | PardubicePardubice |
| |
| 27 Nov 21 | r16 | PardubicePardubice | 1 - 5 | Sigma OlomoucSigma Olomouc |
| |
| 05 Dec 21 | r17 | Mlada BoleslavMlada Bolesla | 2 - 3 | PardubicePardubice |
| |
| 11 Dec 21 | r18 | PardubicePardubice | 0 - 3 | Banik OstravaBanik Ostrava |
| |
| 18 Dec 21 | r19 | Bohemians 1905Bohemians 190 | 1 - 2 | PardubicePardubice |
| |
| 19 Feb 22 | r22 | PardubicePardubice | 0 - 0 | Hradec KrálovéHradec Králov |
| |
| 22 Feb 22 | r20 | PardubicePardubice | 0 - 0 | SlovackoSlovacko |
| |
| 26 Feb 22 | r23 | Viktoria PlzenViktoria Plze | 4 - 0 | PardubicePardubice |
| |
| 05 Mar 22 | r24 | PardubicePardubice | 3 - 3 | Dynamo České BudějoviceDynamo České |
| |
| 09 Mar 22 | r21 | LiberecLiberec | 4 - 1 | PardubicePardubice |
| |
| 13 Mar 22 | r25 | Sparta PragueSparta Prague | 3 - 1 | PardubicePardubice |
| |
| 19 Mar 22 | r26 | ZlínZlín | 4 - 1 | PardubicePardubice |
| |
| 03 Apr 22 | r27 | PardubicePardubice | 1 - 1 | JablonecJablonec |
| |
| 10 Apr 22 | r28 | Slavia PragueSlavia Prague | 4 - 0 | PardubicePardubice |
| |
| 17 Apr 22 | r29 | PardubicePardubice | 2 - 0 | TepliceTeplice |
| |
| 20 Apr 22 | r30 | KarvinaKarvina | 3 - 2 | PardubicePardubice |
| |
| 23 Apr 22 | r01 | JablonecJablonec | 0 - 1 | PardubicePardubice |
| |
| 01 May 22 | r02 | Bohemians 1905Bohemians 190 | 0 - 1 | PardubicePardubice |
| |
| 07 May 22 | r03 | PardubicePardubice | 2 - 0 | KarvinaKarvina |
| |
| 10 May 22 | r04 | PardubicePardubice | 1 - 1 | ZlínZlín |
| |
| 14 May 22 | r05 | TepliceTeplice | 0 - 2 | PardubicePardubice |
Team 2021-2022 Schedules
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Baník Ostrava
Bohemians 1905
Hradec Králové
Jablonec
Mladá Boleslav
Pardubice
Sigma Olomouc
Slavia Prague
Slovácko
Slovan Liberec
Sparta Prague
Teplice
Viktoria Plzeň
Zbrojovka Brno
Zlín
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