| 24 Jul 21 | r01    | Hradec KrálovéHradec Králov | 1 - 1 | Bohemians 1905Bohemians 190 |
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| 01 Aug 21 | r02 | Bohemians 1905Bohemians 190 | 1 - 2 | Viktoria PlzenViktoria Plze |
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| 08 Aug 21 | r03  | JablonecJablonec | 2 - 2 | Bohemians 1905Bohemians 190 |
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| 14 Aug 21 | r04 | Bohemians 1905Bohemians 190 | 1 - 1 | Sparta PragueSparta Prague |
| |
| 21 Aug 21 | r05 | PardubicePardubice | 3 - 0 | Bohemians 1905Bohemians 190 |
| |
| 29 Aug 21 | r06 | Bohemians 1905Bohemians 190 | 4 - 2 | TepliceTeplice |
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| 11 Sep 21 | r07 | ZlínZlín | 1 - 3 | Bohemians 1905Bohemians 190 |
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| 19 Sep 21 | r08 | Bohemians 1905Bohemians 190 | 1 - 5 | Slavia PragueSlavia Prague |
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| 25 Sep 21 | r09 | Banik OstravaBanik Ostrava | 4 - 1 | Bohemians 1905Bohemians 190 |
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| 02 Oct 21 | r10 | Bohemians 1905Bohemians 190 | 2 - 0 | Sigma OlomoucSigma Olomouc |
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| 16 Oct 21 | r11 | Mlada BoleslavMlada Bolesla | 4 - 1 | Bohemians 1905Bohemians 190 |
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| 23 Oct 21 | r12 | SlovackoSlovacko | 1 - 0 | Bohemians 1905Bohemians 190 |
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| 06 Nov 21 | r14 | LiberecLiberec | 2 - 1 | Bohemians 1905Bohemians 190 |
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| 20 Nov 21 | r15 | Bohemians 1905Bohemians 190 | 3 - 1 | Dynamo České BudějoviceDynamo České |
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| 27 Nov 21 | r16 | Viktoria PlzenViktoria Plze | 6 - 0 | Bohemians 1905Bohemians 190 |
| |
| 01 Dec 21 | r13 | Bohemians 1905Bohemians 190 | 3 - 0 | KarvinaKarvina |
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| 05 Dec 21 | r17 | Bohemians 1905Bohemians 190 | 1 - 2 | JablonecJablonec |
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| 12 Dec 21 | r18 | Sparta PragueSparta Prague | 5 - 1 | Bohemians 1905Bohemians 190 |
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| 18 Dec 21 | r19 | Bohemians 1905Bohemians 190 | 1 - 2 | PardubicePardubice |
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| 05 Feb 22 | r20 | TepliceTeplice | 1 - 0 | Bohemians 1905Bohemians 190 |
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| 12 Feb 22 | r21 | Bohemians 1905Bohemians 190 | 1 - 0 | ZlínZlín |
| |
| 20 Feb 22 | r22 | Slavia PragueSlavia Prague | 1 - 0 | Bohemians 1905Bohemians 190 |
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| 26 Feb 22 | r23 | Bohemians 1905Bohemians 190 | 0 - 2 | Banik OstravaBanik Ostrava |
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| 05 Mar 22 | r24 | Sigma OlomoucSigma Olomouc | 0 - 0 | Bohemians 1905Bohemians 190 |
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| 12 Mar 22 | r25 | Bohemians 1905Bohemians 190 | 2 - 2 | Mlada BoleslavMlada Bolesla |
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| 19 Mar 22 | r26 | Bohemians 1905Bohemians 190 | 1 - 2 | SlovackoSlovacko |
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| 03 Apr 22 | r27 | KarvinaKarvina | 1 - 1 | Bohemians 1905Bohemians 190 |
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| 09 Apr 22 | r28 | Bohemians 1905Bohemians 190 | 0 - 0 | LiberecLiberec |
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| 17 Apr 22 | r29 | Dynamo České BudějoviceDynamo České | 2 - 1 | Bohemians 1905Bohemians 190 |
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| 20 Apr 22 | r30 | Bohemians 1905Bohemians 190 | 1 - 1 | Hradec KrálovéHradec Králov |
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| 23 Apr 22 | r01 | TepliceTeplice | 2 - 2 | Bohemians 1905Bohemians 190 |
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| 01 May 22 | r02 | Bohemians 1905Bohemians 190 | 0 - 1 | PardubicePardubice |
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| 07 May 22 | r03 | ZlínZlín | 1 - 4 | Bohemians 1905Bohemians 190 |
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| 10 May 22 | r04 | JablonecJablonec | 1 - 1 | Bohemians 1905Bohemians 190 |
| |
| 14 May 22 | r05 | Bohemians 1905Bohemians 190 | 4 - 0 | KarvinaKarvina |
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| 19 May 22 | r00 | SFC OpavaSFC Opava | 0 - 1 | Bohemians 1905Bohemians 190 |
| 22 May 22 | r00 | Bohemians 1905Bohemians 190 | 2 - 0 | SFC OpavaSFC Opava |
Team 2021-2022 Schedules
Artis Brno
Baník Ostrava
Bohemians 1905
Hradec Králové
Jablonec
Mladá Boleslav
Pardubice
Sigma Olomouc
Slavia Prague
Slovácko
Slovan Liberec
Sparta Prague
Teplice
Viktoria Plzeň
Zbrojovka Brno
Zlín
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