| 25 Apr 21 | r01  | Nanjing CityNanjing City | 1 - 1 | Nantong ZhiyunNantong Zhiyu |
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| 01 May 21 | r02 | Nantong ZhiyunNantong Zhiyu | 1 - 0 | KunshanKunshan |
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| 06 May 21 | r03 | Nantong ZhiyunNantong Zhiyu | 2 - 1 | Beijing BSUBeijing BSU |
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| 10 May 21 | r04 | Jiangxi BeidamenJiangxi Beida | 1 - 3 | Nantong ZhiyunNantong Zhiyu |
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| 16 May 21 | r05 | Nantong ZhiyunNantong Zhiyu | 1 - 2 | Chengdu Better CityChengdu Bette |
| |
| 21 May 21 | r06 | Nantong ZhiyunNantong Zhiyu | 3 - 1 | Nanjing CityNanjing City |
| |
| 25 May 21 | r07 | KunshanKunshan | 1 - 1 | Nantong ZhiyunNantong Zhiyu |
| |
| 30 May 21 | r08 | Beijing BSUBeijing BSU | 1 - 2 | Nantong ZhiyunNantong Zhiyu |
| |
| 04 Jun 21 | r09 | Nantong ZhiyunNantong Zhiyu | 3 - 2 | Jiangxi BeidamenJiangxi Beida |
| |
| 09 Jun 21 | r10 | Chengdu Better CityChengdu Bette | 1 - 0 | Nantong ZhiyunNantong Zhiyu |
| |
| 11 Jul 21 | r01 | Nantong ZhiyunNantong Zhiyu | 4 - 3 | Heilongjiang Lava SpringHeilongjiang |
| |
| 16 Jul 21 | r02 | Hangzhou GreentownHangzhou Gree | 1 - 0 | Nantong ZhiyunNantong Zhiyu |
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| 22 Jul 21 | r03 | Nantong ZhiyunNantong Zhiyu | 3 - 0 | Beijing BITBeijing BIT |
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| 27 Jul 21 | r04 | Meizhou HakkaMeizhou Hakka | 2 - 1 | Nantong ZhiyunNantong Zhiyu |
| |
| 31 Jul 21 | r05 | Heilongjiang Lava SpringHeilongjiang | 0 - 0 | Nantong ZhiyunNantong Zhiyu |
| |
| 05 Aug 21 | r06 | Nantong ZhiyunNantong Zhiyu | 1 - 1 | Hangzhou GreentownHangzhou Gree |
| |
| 10 Aug 21 | r07 | Beijing BITBeijing BIT | 0 - 1 | Nantong ZhiyunNantong Zhiyu |
| |
| 15 Aug 21 | r08 | Nantong ZhiyunNantong Zhiyu | 0 - 1 | Meizhou HakkaMeizhou Hakka |
| |
| 05 Sep 21 | r09 | Nantong ZhiyunNantong Zhiyu | 0 - 1 | Guizhou Hengfeng ZhichengGuizhou Hengf |
| |
| 09 Sep 21 | r10 | Zibo CujuZibo Cuju | 0 - 5 | Nantong ZhiyunNantong Zhiyu |
| |
| 13 Sep 21 | r11 | Nantong ZhiyunNantong Zhiyu | 1 - 2 | Wuhan Three TownsWuhan Three T |
| |
| 18 Sep 21 | r12 | Xinjiang Tianshan LeopardXinjiang Tian | 0 - 3 | Nantong ZhiyunNantong Zhiyu |
| |
| 21 Sep 21 | r13 | Guizhou Hengfeng ZhichengGuizhou Hengf | 0 - 2 | Nantong ZhiyunNantong Zhiyu |
| |
| 25 Sep 21 | r14 | Nantong ZhiyunNantong Zhiyu | 4 - 2 | Zibo CujuZibo Cuju |
| |
| 01 Oct 21 | r15 | Wuhan Three TownsWuhan Three T | 2 - 0 | Nantong ZhiyunNantong Zhiyu |
| |
| 05 Oct 21 | r16  | Nantong ZhiyunNantong Zhiyu | 3 - 0 | Xinjiang Tianshan LeopardXinjiang Tian |
| |
| 27 Nov 21 | r17 | Nantong ZhiyunNantong Zhiyu | 4 - 0 | Liaoning Shenyang UrbanLiaoning Shen |
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| 30 Nov 21 | r18 | Suzhou DongwuSuzhou Dongwu | 0 - 1 | Nantong ZhiyunNantong Zhiyu |
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| 04 Dec 21 | r19 | Sichuan JiuniuSichuan Jiuni | 0 - 2 | Nantong ZhiyunNantong Zhiyu |
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| 08 Dec 21 | r20 | Nantong ZhiyunNantong Zhiyu | 1 - 2 | Shaanxi Chang\'an AthletiShaanxi Chang |
| |
| 11 Dec 21 | r21 | Liaoning Shenyang UrbanLiaoning Shen | 0 - 3 | Nantong ZhiyunNantong Zhiyu |
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| 15 Dec 21 | r22 | Nantong ZhiyunNantong Zhiyu | 3 - 1 | Suzhou DongwuSuzhou Dongwu |
| |
| 18 Dec 21 | r23 | Nantong ZhiyunNantong Zhiyu | 2 - 0 | Sichuan JiuniuSichuan Jiuni |
| |
| 21 Dec 21 | r24 | Shaanxi Chang\'an AthletiShaanxi Chang | 1 - 1 | Nantong ZhiyunNantong Zhiyu |
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