| 10 Nov 21 |
r00        | East CarolinaEast Carolina | 70 - 62 | South Carolina StateSouth Carolin |
| 13 Nov 21 |
r00        | East CarolinaEast Carolina | 83 - 71 | CanisiusCanisius |
| 14 Nov 21 |
r00        | East CarolinaEast Carolina | 95 - 79 | Western CarolinaWestern Carol |
| 19 Nov 21 |
r00        | East CarolinaEast Carolina | 74 - 79 | OklahomaOklahoma |
| 20 Nov 21 |
r00        | Old DominionOld Dominion | 60 - 73 | East CarolinaEast Carolina |
| 21 Nov 21 |
r00        | East CarolinaEast Carolina | 67 - 76 | DavidsonDavidson |
| 27 Nov 21 |
r00        | East CarolinaEast Carolina | 70 - 68 | Coppin StateCoppin State |
| 01 Dec 21 |
r00        | East CarolinaEast Carolina | 63 - 62 | Old DominionOld Dominion |
| 04 Dec 21 |
r00        | East CarolinaEast Carolina | 62 - 52 | Gardner-WebbGardner-Webb |
| 08 Dec 21 |
r00        | East CarolinaEast Carolina | 82 - 71 | North Carolina A&TNorth Carolin |
| 17 Dec 21 |
r00        | East CarolinaEast Carolina | 64 - 74 | LibertyLiberty |
| 21 Dec 21 |
r00        | East CarolinaEast Carolina | 68 - 67 | Southern MississippiSouthern Miss |
| 30 Dec 21 |
r00        | East CarolinaEast Carolina | P - P | Wichita StateWichita State |
| 01 Jan 22 |
r00        | South FloridaSouth Florida | P - P | East CarolinaEast Carolina |
| 06 Jan 22 |
r00        | East CarolinaEast Carolina | 88 - 80 | TulaneTulane |
| 08 Jan 22 |
r00        | TempleTemple | 78 - 75 | East CarolinaEast Carolina |
| 13 Jan 22 |
r00        | CincinnatiCincinnati | 79 - 71 | East CarolinaEast Carolina |
| 15 Jan 22 |
r00        | East CarolinaEast Carolina | 72 - 71 | MemphisMemphis |
| 19 Jan 22 |
r00        | East CarolinaEast Carolina | 85 - 92 | UCF KnightsUCF Knights |
| 22 Jan 22 |
r00        | HoustonHouston | 79 - 36 | East CarolinaEast Carolina |
| 28 Jan 22 |
r00        | MemphisMemphis | 71 - 54 | East CarolinaEast Carolina |
| 30 Jan 22 |
r00        | East CarolinaEast Carolina | 59 - 60 | CincinnatiCincinnati |
| 03 Feb 22 |
r00        | East CarolinaEast Carolina | 63 - 71 | TempleTemple |
| 05 Feb 22 |
r00        | TulaneTulane | 86 - 66 | East CarolinaEast Carolina |
| 09 Feb 22 |
r00        | TulsaTulsa | 71 - 73 | East CarolinaEast Carolina |
| 12 Feb 22 |
r00        | East CarolinaEast Carolina | 66 - 80 | Southern MethodistSouthern Meth |
| 18 Feb 22 |
r00        | South FloridaSouth Florida | 57 - 65 | East CarolinaEast Carolina |
| 20 Feb 22 |
r00        | UCF KnightsUCF Knights | 69 - 66 | East CarolinaEast Carolina |
| 24 Feb 22 |
r00        | East CarolinaEast Carolina | 64 - 60 | South FloridaSouth Florida |
| 26 Feb 22 |
r00        | East CarolinaEast Carolina | 64 - 59 | TulsaTulsa |
| 05 Mar 22 |
r00        | Wichita StateWichita State | 70 - 62 | East CarolinaEast Carolina |
| 10 Mar 22 |
r00        | CincinnatiCincinnati | 74 - 63 | East CarolinaEast Carolina |