| 10 Nov 21 |
r00        | East CarolinaEast Carolina | 70 - 62 | South Carolina StateSouth Carolin |
| 12 Nov 21 |
r00        | College of CharlestonCollege of Ch | 106 - 74 | South Carolina StateSouth Carolin |
| 12 Nov 21 |
r00        | Loyola-MarylandLoyola-Maryla | 75 - 65 | South Carolina StateSouth Carolin |
| 14 Nov 21 |
r00        | South Carolina StateSouth Carolin | 81 - 93 | LipscombLipscomb |
| 17 Nov 21 |
r00        | GeorgiaGeorgia | 76 - 60 | South Carolina StateSouth Carolin |
| 24 Nov 21 |
r00        | South Carolina StateSouth Carolin | 78 - 82 | USC UpstateUSC Upstate |
| 28 Nov 21 |
r00        | South Carolina StateSouth Carolin | 79 - 91 | The CitadelThe Citadel |
| 04 Dec 21 |
r00        | South FloridaSouth Florida | 64 - 65 | South Carolina StateSouth Carolin |
| 11 Dec 21 |
r00        | South Carolina StateSouth Carolin | 66 - 67 | High PointHigh Point |
| 15 Dec 21 |
r00        | DukeDuke | 103 - 62 | South Carolina StateSouth Carolin |
| 18 Dec 21 |
r00        | South Carolina StateSouth Carolin | 90 - 88 | Tennessee StateTennessee Sta |
| 20 Dec 21 |
r00        | The CitadelThe Citadel | 57 - 74 | South Carolina StateSouth Carolin |
| 21 Dec 21 |
r00        | Charleston SouthernCharleston So | 65 - 75 | South Carolina StateSouth Carolin |
| 29 Dec 21 |
r00        | South CarolinaSouth Carolin | P - P | South Carolina StateSouth Carolin |
| 08 Jan 22 |
r00        | South Carolina StateSouth Carolin | 65 - 74 | Coppin StateCoppin State |
| 10 Jan 22 |
r00        | South Carolina StateSouth Carolin | 81 - 88 | Morgan StateMorgan State |
| 22 Jan 22 |
r00        | Maryland-Eastern ShoreMaryland-East | 60 - 69 | South Carolina StateSouth Carolin |
| 25 Jan 22 |
r00        | Delaware StateDelaware Stat | 62 - 64 | South Carolina StateSouth Carolin |
| 29 Jan 22 |
r00        | South Carolina StateSouth Carolin | 69 - 87 | Norfolk StateNorfolk State |
| 01 Feb 22 |
r00        | South Carolina StateSouth Carolin | 58 - 55 | HowardHoward |
| 08 Feb 22 |
r00        | South Carolina StateSouth Carolin | 74 - 68 | North Carolina CentralNorth Carolin |
| 12 Feb 22 |
r00        | Coppin StateCoppin State | 58 - 66 | South Carolina StateSouth Carolin |
| 15 Feb 22 |
r00        | Morgan StateMorgan State | 76 - 66 | South Carolina StateSouth Carolin |
| 19 Feb 22 |
r00        | South Carolina StateSouth Carolin | 70 - 63 | Maryland-Eastern ShoreMaryland-East |
| 22 Feb 22 |
r00        | South Carolina StateSouth Carolin | 79 - 74 | Delaware StateDelaware Stat |
| 26 Feb 22 |
r00        | Norfolk StateNorfolk State | 63 - 59 | South Carolina StateSouth Carolin |
| 01 Mar 22 |
r00        | HowardHoward | 72 - 62 | South Carolina StateSouth Carolin |
| 04 Mar 22 |
r00        | North Carolina CentralNorth Carolin | 67 - 62 | South Carolina StateSouth Carolin |
| 10 Mar 22 |
r00        | Morgan StateMorgan State | 80 - 77 | South Carolina StateSouth Carolin |