| 16 Oct 21 | r01   | Hermine Nantes BasketHermine Nante | 91 - 60 | Denain Voltaire BasketDenain Voltai |
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| 23 Oct 21 | r02 | Saint-Vallier Basket DrômSaint-Vallier | 62 - 69 | Hermine Nantes BasketHermine Nante |
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| 29 Oct 21 | r03 | Hermine Nantes BasketHermine Nante | 86 - 100 | Élan ChalonÉlan Chalon |
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| 05 Nov 21 | r04 | ALM Évreux BasketALM Évreux Ba | 118 - 107 | Hermine Nantes BasketHermine Nante |
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| 09 Nov 21 | r05 | Hermine Nantes BasketHermine Nante | 91 - 63 | RouenRouen |
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| 12 Nov 21 | r06 | Alliance Sport AlsaceAlliance Spor | 73 - 87 | Hermine Nantes BasketHermine Nante |
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| 19 Nov 21 | r07 | Hermine Nantes BasketHermine Nante | 84 - 92 | Union Tours Basket MétropUnion Tours B |
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| 04 Dec 21 | r08 | ADA BloisADA Blois | 56 - 68 | Hermine Nantes BasketHermine Nante |
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| 12 Dec 21 | r09 | Hermine Nantes BasketHermine Nante | 77 - 81 | SLUC Nancy BasketSLUC Nancy Ba |
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| 17 Dec 21 | r10 | Hermine Nantes BasketHermine Nante | 82 - 84 | Antibes SharksAntibes Shark |
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| 23 Dec 21 | r11 | UJAP Quimper 29UJAP Quimper | 79 - 98 | Hermine Nantes BasketHermine Nante |
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| 27 Dec 21 | r12 | Hermine Nantes BasketHermine Nante | 84 - 92 | Boulazac Basket DordogneBoulazac Bask |
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| 12 Jan 22 | r13 | AMSBAMSB | 76 - 72 | Hermine Nantes BasketHermine Nante |
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| 14 Jan 22 | r14 | Saint-Chamond BasketSaint-Chamond | 81 - 74 | Hermine Nantes BasketHermine Nante |
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| 28 Jan 22 | r17 | Hermine Nantes BasketHermine Nante | 66 - 90 | Lille Métropole BCLille Métropo |
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| 04 Feb 22 | r18 | Antibes SharksAntibes Shark | 86 - 63 | Hermine Nantes BasketHermine Nante |
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| 11 Feb 22 | r20 | Hermine Nantes BasketHermine Nante | 71 - 66 | ALM Évreux BasketALM Évreux Ba |
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| 19 Feb 22 | r19 | Boulazac Basket DordogneBoulazac Bask | 90 - 82 | Hermine Nantes BasketHermine Nante |
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| 05 Mar 22 | r21 | SLUC Nancy BasketSLUC Nancy Ba | 82 - 56 | Hermine Nantes BasketHermine Nante |
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| 08 Mar 22 | r22 | Hermine Nantes BasketHermine Nante | 63 - 72 | UJAP Quimper 29UJAP Quimper |
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| 11 Mar 22 | r23 | Hermine Nantes BasketHermine Nante | 91 - 71 | JA Vichy-Clermont MétropoJA Vichy-Cler |
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| 18 Mar 22 | r24 | Denain Voltaire BasketDenain Voltai | 73 - 66 | Hermine Nantes BasketHermine Nante |
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| 22 Mar 22 | r15 | Hermine Nantes BasketHermine Nante | 87 - 74 | Saint-Quentin Basket-BallSaint-Quentin |
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| 25 Mar 22 | r25 | Lille Métropole BCLille Métropo | 85 - 87 | Hermine Nantes BasketHermine Nante |
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| 29 Mar 22 | r16 | JA Vichy-Clermont MétropoJA Vichy-Cler | 75 - 81 | Hermine Nantes BasketHermine Nante |
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| 01 Apr 22 | r26 | Hermine Nantes BasketHermine Nante | 69 - 78 | ADA BloisADA Blois |
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| 05 Apr 22 | r27 | Saint-Quentin Basket-BallSaint-Quentin | 70 - 51 | Hermine Nantes BasketHermine Nante |
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| 08 Apr 22 | r28 | Hermine Nantes BasketHermine Nante | 85 - 96 | Saint-Chamond BasketSaint-Chamond |
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| 15 Apr 22 | r29 | RouenRouen | 110 - 74 | Hermine Nantes BasketHermine Nante |
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| 24 Apr 22 | r30 | Hermine Nantes BasketHermine Nante | 82 - 71 | Alliance Sport AlsaceAlliance Spor |
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| 29 Apr 22 | r31 | Union Tours Basket MétropUnion Tours B | 87 - 86 | Hermine Nantes BasketHermine Nante |
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| 04 May 22 | r32 | Hermine Nantes BasketHermine Nante | 74 - 66 | AMSBAMSB |
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| 07 May 22 | r33 | Élan ChalonÉlan Chalon | 86 - 91 | Hermine Nantes BasketHermine Nante |
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| 13 May 22 | r34 | Hermine Nantes BasketHermine Nante | 85 - 71 | Saint-Vallier Basket DrômSaint-Vallier |
Team 2021-2022 Schedules
ADA Blois
Alliance Sport Alsace
ALM Évreux Basket
AMSB
Antibes Sharks
Caen Basket Calvados
Challans Basket
Châlons-Reims
Chorale Roanne Basket
Denain Voltaire Basket
Élan Béarnais
Hermine Nantes Basket
HTV Basket
JA Vichy
Orléans Loiret Basket
Poitiers Basket 86
Rouen Métropole Basket
Saint-Chamond Basket
Stade Rochelais Basket
UJAP Quimper 29
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