| 15 Oct 21 | r01        | RouenRouen | 68 - 92 | Antibes SharksAntibes Shark |
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| 23 Oct 21 | r02        | Élan ChalonÉlan Chalon | 71 - 62 | RouenRouen |
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| 29 Oct 21 | r03        | RouenRouen | 59 - 76 | Denain Voltaire BasketDenain Voltai |
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| 05 Nov 21 | r04        | RouenRouen | 72 - 96 | Saint-Chamond BasketSaint-Chamond |
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| 09 Nov 21 | r05        | Hermine Nantes BasketHermine Nante | 91 - 63 | RouenRouen |
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| 14 Nov 21 | r06        | RouenRouen | 97 - 89 | Union Tours Basket MétropUnion Tours B |
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| 20 Nov 21 | r07        | UJAP Quimper 29UJAP Quimper | 105 - 64 | RouenRouen |
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| 03 Dec 21 | r08        | RouenRouen | 75 - 95 | Boulazac Basket DordogneBoulazac Bask |
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| 12 Dec 21 | r09        | ALM Évreux BasketALM Évreux Ba | 79 - 80 | RouenRouen |
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| 18 Dec 21 | r10        | ADA BloisADA Blois | 78 - 72 | RouenRouen |
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| 23 Dec 21 | r11        | RouenRouen | 69 - 92 | Saint-Vallier Basket DrômSaint-Vallier |
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| 27 Dec 21 | r12        | RouenRouen | 85 - 84 | SLUC Nancy BasketSLUC Nancy Ba |
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| 11 Jan 22 | r13        | Lille Métropole BCLille Métropo | 86 - 77 | RouenRouen |
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| 21 Jan 22 | r15        | AMSBAMSB | 74 - 68 | RouenRouen |
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| 25 Jan 22 | r16        | RouenRouen | 81 - 85 | Alliance Sport AlsaceAlliance Spor |
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| 28 Jan 22 | r17        | Saint-Quentin Basket-BallSaint-Quentin | 80 - 77 | RouenRouen |
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| 04 Feb 22 | r18        | Saint-Vallier Basket DrômSaint-Vallier | 94 - 88 | RouenRouen |
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| 08 Feb 22 | r19        | RouenRouen | 81 - 84 | ADA BloisADA Blois |
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| 11 Feb 22 | r20        | RouenRouen | 103 - 92 | Élan ChalonÉlan Chalon |
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| 04 Mar 22 | r21        | Alliance Sport AlsaceAlliance Spor | 90 - 75 | RouenRouen |
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| 08 Mar 22 | r22        | RouenRouen | 84 - 90 | Saint-Quentin Basket-BallSaint-Quentin |
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| 12 Mar 22 | r23        | Union Tours Basket MétropUnion Tours B | 93 - 74 | RouenRouen |
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| 15 Mar 22 | r14        | RouenRouen | 95 - 104 | JA Vichy-Clermont MétropoJA Vichy-Cler |
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| 18 Mar 22 | r24        | RouenRouen | 81 - 91 | Lille Métropole BCLille Métropo |
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| 25 Mar 22 | r25        | Saint-Chamond BasketSaint-Chamond | 91 - 69 | RouenRouen |
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| 01 Apr 22 | r26        | RouenRouen | 81 - 88 | ALM Évreux BasketALM Évreux Ba |
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| 05 Apr 22 | r27        | Denain Voltaire BasketDenain Voltai | 96 - 68 | RouenRouen |
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| 09 Apr 22 | r28        | Boulazac Basket DordogneBoulazac Bask | 96 - 97 | RouenRouen |
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| 15 Apr 22 | r29        | RouenRouen | 110 - 74 | Hermine Nantes BasketHermine Nante |
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| 22 Apr 22 | r30        | JA Vichy-Clermont MétropoJA Vichy-Cler | 87 - 80 | RouenRouen |
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| 29 Apr 22 | r31        | RouenRouen | 70 - 93 | UJAP Quimper 29UJAP Quimper |
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| 03 May 22 | r32        | SLUC Nancy BasketSLUC Nancy Ba | 98 - 93 | RouenRouen |
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| 06 May 22 | r33        | RouenRouen | 72 - 77 | AMSBAMSB |
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| 13 May 22 | r34        | Antibes SharksAntibes Shark | 102 - 77 | RouenRouen |