| 16 Mar 22 | r03  | HIFK FotbollHIFK Fotboll | 3 - 0 | PIFPIF |
| 16 Mar 22 | r03 | GIF SundsvallGIF Sundsvall | 1 - 4 | SiriusSirius |
| 16 Mar 22 | r03 | SogndalSogndal | 1 - 1 | AalesundAalesund |
| 16 Mar 22 | r03 | HJK HelsinkiHJK Helsinki | 2 - 0 | MariehamnMariehamn |
| 16 Mar 22 | r03 | Kristiansund BKKristiansund | 1 - 1 | FK HaugesundFK Haugesund |
| 16 Mar 22 | r03 | GaisGais | 2 - 2 | Tvååkers IFTvååkers IF |
| 17 Mar 22 | r03 | HackenHacken | 4 - 3 | Utsiktens BKUtsiktens BK |
| 18 Mar 22 | r03 | IlvesIlves | 3 - 4 | AC OuluAC Oulu |
| 18 Mar 22 | r03 | VaalerengaVaalerenga | 1 - 3 | HamarkamerateneHamarkamerate |
| 18 Mar 22 | r03 | RaufossRaufoss | 2 - 2 | KongsvingerKongsvinger |
| 18 Mar 22 | r03 | NorrkopingNorrkoping | 1 - 0 | AIKAIK |
| 18 Mar 22 | r03 | BrommapojkarnaBrommapojkarn | 3 - 2 | Stockholm InternazionaleStockholm Int |
| 18 Mar 22 | r03 | Motala AIFMotala AIF | 0 - 2 | OerebroOerebro |
| 18 Mar 22 | r03 | StrommenStrommen | - | SkeidSkeid |
| 18 Mar 22 | r03 | IFK GothenburgIFK Gothenbur | 0 - 3 | NorrbyNorrby |
| 19 Mar 22 | r03 | AueAue | - | VfB AuerbachVfB Auerbach |
| 19 Mar 22 | r03 | KPVKPV | 2 - 1 | JJKJJK |
| 19 Mar 22 | r03 | AalesundAalesund | 0 - 2 | BrannBrann |
| 19 Mar 22 | r03 | HelsingborgHelsingborg | 3 - 0 | HalmstadHalmstad |
| 19 Mar 22 | r03 | Trelleborgs FFTrelleborgs F | 2 - 0 | IFK VarnamoIFK Varnamo |
| 19 Mar 22 | r03 | Osters IFOsters IF | 3 - 0 | Skövde AIKSkövde AIK |
| 19 Mar 22 | r03 | PEPOPEPO | 2 - 4 | KTPKTP |
| 19 Mar 22 | r03 | SandefjordSandefjord | 1 - 3 | StabaekStabaek |
| 19 Mar 22 | r03 | MjallbyMjallby | 3 - 1 | Kalmar FFKalmar FF |
| 19 Mar 22 | r03 | DegerforsDegerfors | 0 - 2 | Joenkoeping S.Joenkoeping S |
| 19 Mar 22 | r03 | OstersundOstersund | 2 - 1 | LevangerLevanger |
| 19 Mar 22 | r03 | IK BrageIK Brage | 3 - 1 | GefleGefle |
| 19 Mar 22 | r03 | SJK SeinajokiSJK Seinajoki | 2 - 1 | VPSVPS |
| 19 Mar 22 | r03 | EIFEIF | 0 - 3 | FC HakaFC Haka |
| 19 Mar 22 | r03 | FredrikstadFredrikstad | 2 - 1 | Ull KisaUll Kisa |
| 19 Mar 22 | r03 | AFC EskilstunaAFC Eskilstun | 2 - 2 | Vaesteraas SKVaesteraas SK |
| 19 Mar 22 | r03 | GIF SundsvallGIF Sundsvall | - | RanheimRanheim |
| 19 Mar 22 | r03 | HJK HelsinkiHJK Helsinki | 1 - 0 | FC LahtiFC Lahti |
| 19 Mar 22 | r03 | StartStart | 1 - 1 | Grorud ILGrorud IL |
| 20 Mar 22 | r03 | HackenHacken | 1 - 2 | Odd BallklubbOdd Ballklubb |
| 20 Mar 22 | r03 | RosenborgRosenborg | 1 - 2 | TromsoTromso |
| 21 Mar 22 | r03 | FredericiaFredericia | 0 - 0 | FC MidtjyllandFC Midtjyllan |
| 21 Mar 22 | r03 | RaufossRaufoss | 2 - 2 | HoenefossHoenefoss |
| 22 Mar 22 | r03 | LandskronaLandskrona | 1 - 0 | Varbergs BoIS FCVarbergs BoIS |
| 22 Mar 22 | r03 | GIF SundsvallGIF Sundsvall | 2 - 0 | Dalkurd FFDalkurd FF |
| 22 Mar 22 | r03 | Falkenbergs FFFalkenbergs F | 1 - 3 | Utsiktens BKUtsiktens BK |
| 22 Mar 22 | r03 | Joenkoeping S.Joenkoeping S | - | Qviding FIFQviding FIF |
| 23 Mar 22 | r03 | HIFK FotbollHIFK Fotboll | 0 - 1 | TPSTPS |
| 23 Mar 22 | r03 | KuPS KuopioKuPS Kuopio | 2 - 0 | MPMP |
| 23 Mar 22 | r03 | Union BerlinUnion Berlin | - | PardubicePardubice |
| 24 Mar 22 | r03 | MonacoMonaco | - | Cercle BruggeCercle Brugge |
| 24 Mar 22 | r03 | CF AmericaCF America | 1 - 2 | TigresTigres |
| 24 Mar 22 | r03 | AaBAaB | 1 - 2 | Vendsyssel FFVendsyssel FF |
| 24 Mar 22 | r03 | Mlada BoleslavMlada Bolesla | 4 - 1 | VlašimVlašim |
| 24 Mar 22 | r03 | St. GilloiseSt. Gilloise | - | Oud-Heverlee LeuvenOud-Heverlee |
| 24 Mar 22 | r03 | Fortuna DüsseldorfFortuna Düsse | 4 - 0 | FC TwenteFC Twente |
| 24 Mar 22 | r03 | SC HeerenveenSC Heerenveen | 1 - 0 | PEC ZwollePEC Zwolle |
| 24 Mar 22 | r03 | Ein FrankfurtEin Frankfurt | 1 - 1 | NurnbergNurnberg |
| 24 Mar 22 | r03 | ViborgViborg | 5 - 4 | HamburgHamburg |
| 24 Mar 22 | r03 | StuttgartStuttgart | 2 - 3 | SandhausenSandhausen |
| 24 Mar 22 | r03 | MainzMainz | - | DarmstadtDarmstadt |
| 24 Mar 22 | r03 | FC Trenkwalder AdmiraFC Trenkwalde | - | Sturm GrazSturm Graz |
| 24 Mar 22 | r03 | LASKLASK | - | SKU AmstettenSKU Amstetten |
| 24 Mar 22 | r03 | MetzMetz | 2 - 0 | Wehen WiesbadenWehen Wiesbad |
| 24 Mar 22 | r03 | VaduzVaduz | 0 - 3 | SC Rheindorf AltachSC Rheindorf |
| 24 Mar 22 | r03 | St. GallenSt. Gallen | 9 - 0 | DornbirnDornbirn |
| 24 Mar 22 | r03 | IngolstadtIngolstadt | 3 - 1 | Wacker BurghausenWacker Burgha |
| 24 Mar 22 | r03 | Sturm GrazSturm Graz | 3 - 2 | SV KapfenbergSV Kapfenberg |
| 24 Mar 22 | r03 | WSG Swarovski TirolWSG Swarovski | 4 - 2 | FC BW LinzFC BW Linz |
| 24 Mar 22 | r03 | Dynamo DresdenDynamo Dresde | 2 - 1 | LiberecLiberec |
| 24 Mar 22 | r03 | KarlsruheKarlsruhe | 6 - 1 | FC BaselFC Basel |
| 24 Mar 22 | r03 | TSV HartbergTSV Hartberg | 2 - 4 | SAK KlagenfurtSAK Klagenfur |
| 25 Mar 22 | r03 | OsijekOsijek | 5 - 0 | CibaliaCibalia |
| 25 Mar 22 | r03 | Viktoria PlzenViktoria Plze | 1 - 1 | Bohemians 1905Bohemians 190 |
| 25 Mar 22 | r03 | NiecieczaNieciecza | 4 - 1 | Stal MielecStal Mielec |
| 25 Mar 22 | r03 | JastrzębieJastrzębie | 1 - 1 | Podbeskidzie Bielsko-BialPodbeskidzie |
| 25 Mar 22 | r03 | Septemvri SofiaSeptemvri Sof | 2 - 1 | Tsarsko SeloTsarsko Selo |
| 25 Mar 22 | r03 | Inter TurkuInter Turku | 0 - 0 | GnistanGnistan |
| 25 Mar 22 | r03 | Rakow CzestochowaRakow Czestoc | 2 - 0 | Skra CzęstochowaSkra Częstoch |
| 25 Mar 22 | r03 | Cracovia KrakowCracovia Krak | 1 - 0 | Sandecja Nowy SaczSandecja Nowy |
| 25 Mar 22 | r03 | Slask WroclawSlask Wroclaw | 5 - 2 | Chrobry GłogówChrobry Głogó |
| 25 Mar 22 | r03 | LucerneLucerne | 4 - 1 | SchaffhausenSchaffhausen |
| 25 Mar 22 | r03 | Gornik LecznaGornik Leczna | 0 - 4 | Resovia RzeszówResovia Rzesz |
| 25 Mar 22 | r03 | BrommapojkarnaBrommapojkarn | 3 - 1 | OergryteOergryte |
| 25 Mar 22 | r03 | MainzMainz | - | Viktoria KölnViktoria Köln |
| 25 Mar 22 | r03 | Jahn RegensburgJahn Regensbu | 0 - 3 | SPVGG Greuther FürthSPVGG Greuthe |
| 25 Mar 22 | r03 | BordeauxBordeaux | 2 - 1 | AlavesAlaves |
| 25 Mar 22 | r03 | BochumBochum | 2 - 0 | SC Heracles AlmeloSC Heracles A |
| 25 Mar 22 | r03 | Silkeborg IFSilkeborg IF | - | Holstein KielHolstein Kiel |
| 25 Mar 22 | r03 | HalmstadHalmstad | 0 - 4 | ElfsborgElfsborg |
| 25 Mar 22 | r03 | RosenborgRosenborg | 0 - 3 | RaufossRaufoss |
| 25 Mar 22 | r03 | GrasshoppersGrasshoppers | 1 - 1 | FC AarauFC Aarau |
| 25 Mar 22 | r03 | Maritsa PlovdivMaritsa Plovd | 1 - 2 | Arda KardzhaliArda Kardzhal |
| 25 Mar 22 | r03 | Szombathelyi HaladásSzombathelyi | 2 - 1 | SV LafnitzSV Lafnitz |
| 25 Mar 22 | r03 | Farul ConstantaFarul Constan | 2 - 0 | Cherno MoreCherno More |
| 25 Mar 22 | r03 | DomzaleDomzale | 1 - 1 | OpatijaOpatija |
| 25 Mar 22 | r03 | Slaven Belupo KoprivnicaSlaven Belupo | 1 - 1 | BSK Bijelo BrdoBSK Bijelo Br |
| 25 Mar 22 | r03 | Olimpija LjubljanaOlimpija Ljub | 2 - 0 | RudešRudeš |
| 25 Mar 22 | r03 | NotoddenNotodden | - | BaerumBaerum |
| 25 Mar 22 | r03 | SV HornSV Horn | 0 - 2 | SKN St. PoltenSKN St. Polte |
| 26 Mar 22 | r03 | Energetik-BGU MinskEnergetik-BGU | 1 - 1 | FK Arsenal DzerzhinskFK Arsenal Dz |
| 26 Mar 22 | r03 | FC VoluntariFC Voluntari | 1 - 1 | PetrolulPetrolul |
| 26 Mar 22 | r03 | Isloch Minsk RaionIsloch Minsk | 2 - 0 | FC OsipovichiFC Osipovichi |
| 26 Mar 22 | r03 | CSKA MoscowCSKA Moscow | 2 - 0 | Nizhny NovgorodNizhny Novgor |
| 26 Mar 22 | r03 | Zaglebie SosnowiecZaglebie Sosn | 1 - 0 | Tychy 71Tychy 71 |
| 26 Mar 22 | r03 | Wisla PlockWisla Plock | 2 - 1 | Stomil OlsztynStomil Olszty |
| 26 Mar 22 | r03 | FC VitebskFC Vitebsk | 1 - 1 | Lokomotiv GomelLokomotiv Gom |
| 26 Mar 22 | r03 | FC MinskFC Minsk | 4 - 0 | BATE BorisovBATE Borisov |
| 26 Mar 22 | r03 | VarnsdorfVarnsdorf | 1 - 0 | Polissya ZhytomyrPolissya Zhyt |
| 26 Mar 22 | r03 | MPMP | 2 - 1 | KTPKTP |
| 26 Mar 22 | r03 | Dinamo MinskDinamo Minsk | 1 - 0 | FC SlutskFC Slutsk |
| 26 Mar 22 | r03 | Arges PitestiArges Pitesti | 2 - 0 | ConcordiaConcordia |
| 26 Mar 22 | r03 | FriggFrigg | 0 - 4 | KFUMKFUM |
| 26 Mar 22 | r03 | FK Rubin KazanFK Rubin Kaza | 0 - 5 | Krylya Sovetov SamaraKrylya Soveto |
| 26 Mar 22 | r03 | VPSVPS | 1 - 0 | JaroJaro |
| 26 Mar 22 | r03 | IFK GothenburgIFK Gothenbur | 3 - 0 | FredrikstadFredrikstad |
| 26 Mar 22 | r03 | SiriusSirius | 3 - 3 | IK BrageIK Brage |
| 26 Mar 22 | r03 | Osters IFOsters IF | 2 - 4 | HelsingborgHelsingborg |
| 26 Mar 22 | r03 | BrommapojkarnaBrommapojkarn | - | Vaesteraas SKVaesteraas SK |
| 26 Mar 22 | r03 | HJK HelsinkiHJK Helsinki | 2 - 2 | HammarbyHammarby |
| 26 Mar 22 | r03 | AIKAIK | 2 - 1 | Joenkoeping S.Joenkoeping S |
| 26 Mar 22 | r03 | Kispest HonvedKispest Honve | 2 - 2 | Szentlőrinc SESzentlőrinc S |
| 26 Mar 22 | r03 | Dinamo BucurestiDinamo Bucure | 2 - 0 | Zimbru ChisinauZimbru Chisin |
| 26 Mar 22 | r03 | FC U Craiova 1948FC U Craiova | 1 - 4 | CSA Steaua BucureştiCSA Steaua Bu |
| 26 Mar 22 | r03 | Nomme KaljuNomme Kalju | 0 - 1 | METTA Latvijas UniversitāMETTA Latvija |
| 26 Mar 22 | r03 | Levski SofiaLevski Sofia | 1 - 1 | SozopolSozopol |
| 26 Mar 22 | r03 | FC Dnepr MogilevFC Dnepr Mogi | 1 - 1 | Naftan NovopolotskNaftan Novopo |
| 26 Mar 22 | r03 | Legia WarsawLegia Warsaw | 2 - 3 | Widzew LodzWidzew Lodz |
| 26 Mar 22 | r03 | Lokomotiv PlovdivLokomotiv Plo | 1 - 2 | Botev VratsaBotev Vratsa |
| 26 Mar 22 | r03 | IlvesIlves | 0 - 0 | PK-35PK-35 |
| 26 Mar 22 | r03 | GaisGais | 2 - 2 | LandskronaLandskrona |
| 26 Mar 22 | r03 | Kalmar FFKalmar FF | 3 - 0 | IFK VarnamoIFK Varnamo |
| 26 Mar 22 | r03 | NorrbyNorrby | 2 - 3 | Varbergs BoIS FCVarbergs BoIS |
| 26 Mar 22 | r03 | MjallbyMjallby | 1 - 1 | Trelleborgs FFTrelleborgs F |
| 26 Mar 22 | r03 | OstersundOstersund | 1 - 1 | GIF SundsvallGIF Sundsvall |
| 26 Mar 22 | r03 | Skövde AIKSkövde AIK | 1 - 0 | TrollhättanTrollhättan |
| 26 Mar 22 | r03 | MariehamnMariehamn | 3 - 1 | EIFEIF |
| 26 Mar 22 | r03 | Grorud ILGrorud IL | 3 - 2 | Ull KisaUll Kisa |
| 26 Mar 22 | r03 | Sarpsborg 08Sarpsborg 08 | 2 - 2 | LillestroemLillestroem |
| 26 Mar 22 | r03 | FC HakaFC Haka | 0 - 1 | KTPKTP |
| 26 Mar 22 | r03 | CukarickiCukaricki | 1 - 1 | SutjeskaSutjeska |
| 26 Mar 22 | r03 | NorrkopingNorrkoping | 1 - 0 | AFC EskilstunaAFC Eskilstun |
| 26 Mar 22 | r03 | OerebroOerebro | 0 - 5 | DegerforsDegerfors |
| 26 Mar 22 | r03 | VaalerengaVaalerenga | 3 - 3 | HackenHacken |
| 26 Mar 22 | r03 | Vaesteraas SKVaesteraas SK | 5 - 0 | KarlstadKarlstad |
| 26 Mar 22 | r03 | MjoendalenMjoendalen | 1 - 0 | StartStart |
| 26 Mar 22 | r03 | Ludogorets RazgradLudogorets Ra | 5 - 1 | Etar Veliko TarnovoEtar Veliko T |
| 26 Mar 22 | r03 | StroemsgodsetStroemsgodset | 1 - 2 | HamarkamerateneHamarkamerate |
| 26 Mar 22 | r03 | Szeged-CsanádSzeged-Csanád | 0 - 1 | FerencvarosFerencvaros |
| 26 Mar 22 | r03 | SogndalSogndal | 0 - 3 | BrannBrann |
| 26 Mar 22 | r03 | ASANE FOTBALLASANE FOTBALL | 3 - 1 | SandnesSandnes |
| 26 Mar 22 | r03 | Odd BallklubbOdd Ballklubb | 2 - 0 | SandefjordSandefjord |
| 26 Mar 22 | r03 | KuPS KuopioKuPS Kuopio | 1 - 0 | AC OuluAC Oulu |
| 26 Mar 22 | r03 | GKS KatowiceGKS Katowice | 0 - 1 | Gornik ZabrzeGornik Zabrze |
| 26 Mar 22 | r03 | Dalkurd FFDalkurd FF | 0 - 3 | SandvikensSandvikens |
| 26 Mar 22 | r03 | Kristiansund BKKristiansund | 0 - 0 | TromsoTromso |
| 26 Mar 22 | r03 | Austria SalzburgAustria Salzb | 1 - 1 | Grazer AKGrazer AK |
| 27 Mar 22 | r03 | Bodoe/GlimtBodoe/Glimt | - | MoldeMolde |
| 27 Mar 22 | r03 | MonterreyMonterrey | 2 - 1 | CF AmericaCF America |
| 27 Mar 22 | r03 | Shakhter SoligorskShakhter Soli | 1 - 1 | Slavia MozyrSlavia Mozyr |
| 27 Mar 22 | r03 | DjurgaardenDjurgaarden | 0 - 2 | HonkaHonka |
| 27 Mar 22 | r03 | Hajduk SplitHajduk Split | 5 - 2 | RadomljeRadomlje |
| 27 Mar 22 | r03 | Khimki FKKhimki FK | 1 - 0 | Lok. MoscowLok. Moscow |
| 27 Mar 22 | r03 | BryneBryne | 1 - 2 | JERVJERV |
| 27 Mar 22 | r03 | Stjørdals-BlinkStjørdals-Bli | 1 - 2 | RanheimRanheim |
| 27 Mar 22 | r03 | CSKA SofiaCSKA Sofia | 3 - 1 | Sportist SvogeSportist Svog |
| 27 Mar 22 | r03 | VikingViking | 1 - 0 | FK HaugesundFK Haugesund |
| 28 Mar 22 | r03 | FC VoluntariFC Voluntari | - | AstraAstra |
| 28 Mar 22 | r03 | StabaekStabaek | 2 - 0 | KongsvingerKongsvinger |
| 28 Mar 22 | r03 | CFR Cluj-NapocaCFR Cluj-Napo | 4 - 0 | Minaur Baia MareMinaur Baia M |
| 29 Mar 22 | r03 | Atletico PRAtletico PR | 4 - 0 | America MGAmerica MG |
| 30 Mar 22 | r03 | MPMP | 3 - 2 | PEPOPEPO |
| 30 Mar 22 | r03 | Levski SofiaLevski Sofia | 3 - 2 | Septemvri SofiaSeptemvri Sof |
| 02 Apr 22 | r03 | TPSTPS | 0 - 0 | Klubi-04Klubi-04 |
| 02 Apr 22 | r03 | EIFEIF | 3 - 1 | JäPSJäPS |
| 02 Apr 22 | r03 | JJKJJK | 2 - 0 | MPMP |
| 02 Apr 22 | r03 | Arendal FotballArendal Fotba | - | NotoddenNotodden |
| 02 Apr 22 | r03 | PK-35PK-35 | 3 - 1 | SJK AkatemiaSJK Akatemia |
| 02 Apr 22 | r03 | Ull KisaUll Kisa | 0 - 1 | StrommenStrommen |
| 07 Apr 22 | r03 | TPSTPS | - | GnistanGnistan |
| 09 Apr 22 | r03 | PK-35PK-35 | 5 - 3 | Tampere UnitedTampere Unite |
| 09 Apr 22 | r03 | OlympiakosOlympiakos | 1 - 0 | Shakhtar DonetskShakhtar Done |
| 12 Apr 22 | r03 | Legia WarsawLegia Warsaw | 1 - 3 | Dynamo KievDynamo Kiev |
| 14 Apr 22 | r03 | Lechia GdańskLechia Gdańsk | 2 - 3 | Shakhtar DonetskShakhtar Done |
| 19 Apr 22 | r03 | Cherno MoreCherno More | 0 - 1 | DobrudzhaDobrudzha |
| 20 Apr 22 | r03 | Steaua BucurestiSteaua Bucure | - | Dynamo KievDynamo Kiev |
| 20 Apr 22 | r03 | CFR Cluj-NapocaCFR Cluj-Napo | 0 - 0 | Dynamo KievDynamo Kiev |
| 23 Apr 22 | r03 | JaroJaro | 0 - 3 | SJK AkatemiaSJK Akatemia |
| 28 Apr 22 | r03 | Dinamo ZagrebDinamo Zagreb | 2 - 2 | Dynamo KievDynamo Kiev |
| 29 Apr 22 | r03 | FredrikstadFredrikstad | 0 - 2 | Odd BallklubbOdd Ballklubb |
| 29 Apr 22 | r03 | RosenborgRosenborg | 3 - 0 | Stjørdals-BlinkStjørdals-Bli |
| 01 May 22 | r03 | Hajduk SplitHajduk Split | 3 - 3 | Shakhtar DonetskShakhtar Done |
| 04 May 22 | r03 | FC BaselFC Basel | 2 - 3 | Dynamo KievDynamo Kiev |
| 13 May 22 | r03 | FC Flora TallinFC Flora Tall | 0 - 3 | Dynamo KievDynamo Kiev |
| 04 Jun 22 | r03 | FC MinskFC Minsk | 3 - 1 | Isloch Minsk RaionIsloch Minsk |
| 04 Jun 22 | r03 | FC Belshina BobruiskFC Belshina B | 7 - 3 | FC Dnepr MogilevFC Dnepr Mogi |
| 05 Jun 22 | r03 | Lokomotiv GomelLokomotiv Gom | 1 - 2 | Slavia MozyrSlavia Mozyr |
| 07 Jun 22 | r03 | Shakhter SoligorskShakhter Soli | 3 - 0 | Neman GrodnoNeman Grodno |
| 08 Jun 22 | r03 | Rapid ViennaRapid Vienna | - | Dynamo KievDynamo Kiev |
| 08 Jun 22 | r03 | DC UnitedDC United | 1 - 0 | XelajúXelajú |
| 10 Jun 22 | r03 | FC VitebskFC Vitebsk | 3 - 0 | FC Dnepr MogilevFC Dnepr Mogi |
| 10 Jun 22 | r03 | ShamrockShamrock | 0 - 0 | Galway UnitedGalway United |
| 11 Jun 22 | r03 | Shakhter SoligorskShakhter Soli | 2 - 0 | Dinamo MinskDinamo Minsk |
| 11 Jun 22 | r03 | Maritsa PlovdivMaritsa Plovd | 0 - 2 | Lokomotiv PlovdivLokomotiv Plo |
| 11 Jun 22 | r03 | GomelGomel | 1 - 0 | Slavia MozyrSlavia Mozyr |
| 11 Jun 22 | r03 | FC SlutskFC Slutsk | 1 - 2 | FC Belshina BobruiskFC Belshina B |
| 11 Jun 22 | r03 | MoldeMolde | 2 - 1 | AIKAIK |
| 11 Jun 22 | r03 | FredrikstadFredrikstad | 3 - 1 | IFK GothenburgIFK Gothenbur |
| 11 Jun 22 | r03 | BATE BorisovBATE Borisov | 1 - 1 | Torpedo-BelAZ ZhodinoTorpedo-BelAZ |
| 11 Jun 22 | r03 | Neman GrodnoNeman Grodno | 3 - 2 | Dynamo BrestDynamo Brest |
| 11 Jun 22 | r03 | CliftonvilleCliftonville | 1 - 2 | Derry CityDerry City |
| 11 Jun 22 | r03 | Kristiansund BKKristiansund | 0 - 1 | Stjørdals-BlinkStjørdals-Bli |
| 11 Jun 22 | r03 | Pirin BlagoevgradPirin Blagoev | 1 - 3 | Septemvri SofiaSeptemvri Sof |
| 12 Jun 22 | r03 | Minnesota UnitedMinnesota Uni | 4 - 3 | PaderbornPaderborn |
| 12 Jun 22 | r03 | Austin FCAustin FC | 1 - 4 | PachucaPachuca |
| 12 Jun 22 | r03 | FC MinskFC Minsk | 0 - 0 | FK Arsenal DzerzhinskFK Arsenal Dz |
| 12 Jun 22 | r03 | JERVJERV | 1 - 5 | TromsoTromso |
| 12 Jun 22 | r03 | LillestroemLillestroem | 0 - 1 | HamarkamerateneHamarkamerate |
| 12 Jun 22 | r03 | Odd BallklubbOdd Ballklubb | 0 - 0 | KFUMKFUM |
| 12 Jun 22 | r03 | FerencvarosFerencvaros | 1 - 1 | Shkendija 79Shkendija 79 |
| 13 Jun 22 | r03 | Ludogorets RazgradLudogorets Ra | 5 - 1 | Strumska SlavaStrumska Slav |
| 13 Jun 22 | r03 | Sarpsborg 08Sarpsborg 08 | 1 - 4 | HackenHacken |
| 13 Jun 22 | r03 | RosenborgRosenborg | 2 - 0 | AalesundAalesund |
| 13 Jun 22 | r03 | Trans NarvaTrans Narva | 1 - 1 | FC Levadia TallinnFC Levadia Ta |
| 14 Jun 22 | r03 | HammarbyHammarby | 2 - 1 | IK BrageIK Brage |
| 14 Jun 22 | r03 | CSKA 1948CSKA 1948 | 5 - 0 | Spartak VarnaSpartak Varna |
| 14 Jun 22 | r03 | FerencvarosFerencvaros | - | Arges PitestiArges Pitesti |
| 15 Jun 22 | r03 | Atlanta UnitedAtlanta Unite | 3 - 2 | PachucaPachuca |
| 15 Jun 22 | r03 | FC Yenisey KrasnoyarskFC Yenisey Kr | - | Baltika KaliningradBaltika Kalin |
| 15 Jun 22 | r03 | San AntonioSan Antonio | 0 - 4 | Atletico de San LuisAtletico de S |
| 15 Jun 22 | r03 | FC Spartak TrnavaFC Spartak Tr | 0 - 0 | SkalicaSkalica |
| 15 Jun 22 | r03 | Cherno MoreCherno More | 0 - 1 | Lokomotiv PlovdivLokomotiv Plo |
| 15 Jun 22 | r03 | Septemvri SofiaSeptemvri Sof | 1 - 0 | Strumska SlavaStrumska Slav |
| 15 Jun 22 | r03 | MFK RužomberokMFK Ružombero | 3 - 1 | HumennéHumenné |
| 15 Jun 22 | r03 | ZrinjskiZrinjski | 2 - 1 | NŠ MuraNŠ Mura |
| 15 Jun 22 | r03 | CeljeCelje | 6 - 1 | Rudar PljevljaRudar Pljevlj |
| 15 Jun 22 | r03 | ZurichZurich | 11 - 0 | BadenBaden |
| 16 Jun 22 | r03 | CD GuadalajaraCD Guadalajar | 3 - 1 | SantosSantos |
| 16 Jun 22 | r03 | HackenHacken | 2 - 0 | HalmstadHalmstad |
| 16 Jun 22 | r03 | Varbergs BoIS FCVarbergs BoIS | 1 - 1 | NorrbyNorrby |
| 16 Jun 22 | r03 | SK Vorwarts SteyrSK Vorwarts S | 0 - 3 | Kalmar FFKalmar FF |
| 17 Jun 22 | r03 | Forward Madison FCForward Madis | 1 - 2 | PaderbornPaderborn |
| 17 Jun 22 | r03 | TSC Bačka TopolaTSC Bačka Top | 3 - 0 | VoždovacVoždovac |
| 17 Jun 22 | r03 | SiriusSirius | 3 - 3 | DjurgaardenDjurgaarden |
| 17 Jun 22 | r03 | Yantra GabrovoYantra Gabrov | 2 - 5 | Botev VratsaBotev Vratsa |
| 17 Jun 22 | r03 | Trelleborgs FFTrelleborgs F | 0 - 2 | IFK GothenburgIFK Gothenbur |
| 17 Jun 22 | r03 | ElfsborgElfsborg | 1 - 0 | HelsingborgHelsingborg |
| 17 Jun 22 | r03 | LucerneLucerne | 2 - 1 | FC WinterthurFC Winterthur |
| 17 Jun 22 | r03 | KolubaraKolubara | 1 - 0 | DečićDečić |
| 18 Jun 22 | r03 | NK LokomotivaNK Lokomotiva | 2 - 0 | HNK GoricaHNK Gorica |
| 18 Jun 22 | r03 | PachucaPachuca | 0 - 3 | Miami UnitedMiami United |
| 18 Jun 22 | r03 | DekaniDekani | 0 - 0 | Olimpija LjubljanaOlimpija Ljub |
| 18 Jun 22 | r03 | Cracovia KrakowCracovia Krak | 3 - 2 | Stal RzeszówStal Rzeszów |
| 18 Jun 22 | r03 | Levski SofiaLevski Sofia | 1 - 1 | Septemvri SofiaSeptemvri Sof |
| 18 Jun 22 | r03 | Fortuna Düsseldorf IIFortuna Düsse | 1 - 3 | Fortuna KölnFortuna Köln |
| 18 Jun 22 | r03 | KosiceKosice | 0 - 0 | MFK Zemplín MichalovceMFK Zemplín M |
| 18 Jun 22 | r03 | GKS KatowiceGKS Katowice | 0 - 0 | Skra CzęstochowaSkra Częstoch |
| 18 Jun 22 | r03 | Korona KielceKorona Kielce | 1 - 1 | NiecieczaNieciecza |
| 18 Jun 22 | r03 | DAC 1904 Dunajská StredaDAC 1904 Duna | 3 - 1 | FK PohronieFK Pohronie |
| 18 Jun 22 | r03 | Stal MielecStal Mielec | 2 - 3 | Puszcza NiepołomicePuszcza Niepo |
| 18 Jun 22 | r03 | TřinecTřinec | 1 - 2 | DubnicaDubnica |
| 18 Jun 22 | r03 | OsijekOsijek | 1 - 0 | Slaven Belupo KoprivnicaSlaven Belupo |
| 18 Jun 22 | r03 | FC Spartak TrnavaFC Spartak Tr | 5 - 1 | FC PetržalkaFC Petržalka |
| 18 Jun 22 | r03 | Tatran Liptovský MikulášTatran Liptov | 5 - 0 | FK Železiarne PodbrezováFK Železiarne |
| 18 Jun 22 | r03 | Lech PoznanLech Poznan | 1 - 2 | Widzew LodzWidzew Lodz |
| 18 Jun 22 | r03 | Gornik LecznaGornik Leczna | 1 - 0 | Radomiak RadomRadomiak Rado |
| 18 Jun 22 | r03 | Slask WroclawSlask Wroclaw | 3 - 1 | Tychy 71Tychy 71 |
| 18 Jun 22 | r03 | AaBAaB | 1 - 0 | Skövde AIKSkövde AIK |
| 18 Jun 22 | r03 | Schwaben AugsburgSchwaben Augs | 4 - 2 | FC PipinsriedFC Pipinsried |
| 18 Jun 22 | r03 | Schalke 04 IISchalke 04 II | - | Stuttgart IIStuttgart II |
| 18 Jun 22 | r03 | Viktoria AschaffenburgViktoria Asch | 0 - 2 | NurnbergNurnberg |
| 18 Jun 22 | r03 | IngolstadtIngolstadt | 1 - 0 | EichstättEichstätt |
| 18 Jun 22 | r03 | ClachnacuddinClachnacuddin | 0 - 5 | Elgin CityElgin City |
| 18 Jun 22 | r03 | DundalkDundalk | 2 - 1 | LarneLarne |
| 18 Jun 22 | r03 | CliftonvilleCliftonville | 0 - 1 | ShamrockShamrock |
| 18 Jun 22 | r03 | CSKA SofiaCSKA Sofia | 1 - 4 | SPVGG Greuther FürthSPVGG Greuthe |
| 18 Jun 22 | r03 | Pirin BlagoevgradPirin Blagoev | 0 - 3 | CSKA 1948CSKA 1948 |
| 18 Jun 22 | r03 | FC BaselFC Basel | 3 - 0 | Neuchâtel XamaxNeuchâtel Xam |
| 18 Jun 22 | r03 | Tekstilshchik IvanovoTekstilshchik | 3 - 3 | Volgar AstrakhanVolgar Astrak |
| 18 Jun 22 | r03 | Sturm GrazSturm Graz | 2 - 0 | SV KapfenbergSV Kapfenberg |
| 18 Jun 22 | r03 | TSV HartbergTSV Hartberg | 2 - 2 | SV LafnitzSV Lafnitz |
| 18 Jun 22 | r03 | Lokomotiv SofiaLokomotiv Sof | 4 - 2 | Litex LovechLitex Lovech |
| 18 Jun 22 | r03 | PartizaniPartizani | 2 - 1 | NŠ MuraNŠ Mura |
| 18 Jun 22 | r03 | NK MariborNK Maribor | 0 - 1 | Shkendija 79Shkendija 79 |
| 18 Jun 22 | r03 | Joenkoeping S.Joenkoeping S | 0 - 0 | HammarbyHammarby |
| 18 Jun 22 | r03 | DornbirnDornbirn | 2 - 3 | Austria LustenauAustria Luste |
| 18 Jun 22 | r03 | LeobendorfLeobendorf | 0 - 1 | SKN St. PoltenSKN St. Polte |
| 18 Jun 22 | r03 | First ViennaFirst Vienna | 5 - 2 | TWL ElektraTWL Elektra |
| 18 Jun 22 | r03 | SV Josko RiedSV Josko Ried | 0 - 3 | Slovan BratislavaSlovan Bratis |
| 18 Jun 22 | r03 | KoperKoper | 0 - 2 | CFR Cluj-NapocaCFR Cluj-Napo |
| 18 Jun 22 | r03 | Arda KardzhaliArda Kardzhal | 3 - 0 | SozopolSozopol |
| 18 Jun 22 | r03 | SKU AmstettenSKU Amstetten | 0 - 0 | MFK RužomberokMFK Ružombero |
| 18 Jun 22 | r03 | ZurichZurich | 3 - 2 | FC WilFC Wil |
| 18 Jun 22 | r03 | FK Železiarne PodbrezováFK Železiarne | 4 - 3 | MSK ZilinaMSK Zilina |
| 18 Jun 22 | r03 | NK VaraždinNK Varaždin | 0 - 3 | ZrinjskiZrinjski |
| 18 Jun 22 | r03 | FK RostovFK Rostov | 5 - 1 | FC Kuban-Holding PavlovskFC Kuban-Hold |
| 18 Jun 22 | r03 | DomzaleDomzale | 8 - 0 | Rudar PljevljaRudar Pljevlj |
| 19 Jun 22 | r03 | KoperKoper | 0 - 2 | VojvodinaVojvodina |
| 19 Jun 22 | r03 | Utsiktens BKUtsiktens BK | 1 - 1 | NorrkopingNorrkoping |
| 19 Jun 22 | r03 | MonterreyMonterrey | 0 - 1 | SantosSantos |
| 19 Jun 22 | r03 | SkalicaSkalica | 1 - 1 | VyškovVyškov |
| 19 Jun 22 | r03 | CeljeCelje | 0 - 0 | CukarickiCukaricki |
| 19 Jun 22 | r03 | SC VerlSC Verl | 9 - 1 | Schwarz-Weiß RehdenSchwarz-Weiß |
| 19 Jun 22 | r03 | Osters IFOsters IF | 1 - 2 | HammarbyHammarby |
| 19 Jun 22 | r03 | AFC EskilstunaAFC Eskilstun | 2 - 0 | GIF SundsvallGIF Sundsvall |
| 19 Jun 22 | r03 | AIKAIK | 3 - 2 | OerebroOerebro |
| 19 Jun 22 | r03 | Buducnost PodgoricaBuducnost Pod | 1 - 1 | Mladost LučaniMladost Lučan |
| 19 Jun 22 | r03 | Slavia SofiaSlavia Sofia | 1 - 2 | Spartak VarnaSpartak Varna |
| 19 Jun 22 | r03 | Ludogorets RazgradLudogorets Ra | 1 - 0 | FC BW LinzFC BW Linz |
| 19 Jun 22 | r03 | Legia WarsawLegia Warsaw | 3 - 1 | Chojniczanka ChojniceChojniczanka |
| 19 Jun 22 | r03 | Novi PazarNovi Pazar | 3 - 1 | Radnik SurdulicaRadnik Surdul |
| 20 Jun 22 | r03 | Torpedo MoscowTorpedo Mosco | 2 - 1 | FC Yenisey KrasnoyarskFC Yenisey Kr |
| 20 Jun 22 | r03 | FC Volga UlyanovskFC Volga Ulya | 2 - 1 | KAMAZ Naberezhnye ChelnyKAMAZ Naberez |
| 20 Jun 22 | r03 | Dukla Banská BystricaDukla Banská | 3 - 2 | TrencinTrencin |
| 20 Jun 22 | r03 | FK Rubin KazanFK Rubin Kaza | 1 - 0 | Akron TolyattiAkron Tolyatt |
| 20 Jun 22 | r03 | OergryteOergryte | 2 - 2 | HackenHacken |
| 20 Jun 22 | r03 | Dalkurd FFDalkurd FF | 1 - 3 | OstersundOstersund |
| 20 Jun 22 | r03 | Torpedo MoscowTorpedo Mosco | 3 - 1 | Tekstilshchik IvanovoTekstilshchik |
| 20 Jun 22 | r03 | SKA-KhabarovskSKA-Khabarovs | 0 - 2 | FC Yenisey KrasnoyarskFC Yenisey Kr |
| 20 Jun 22 | r03 | SV LafnitzSV Lafnitz | 1 - 2 | Arges PitestiArges Pitesti |
| 20 Jun 22 | r03 | Malmo FFMalmo FF | 2 - 0 | Trelleborgs FFTrelleborgs F |
| 20 Jun 22 | r03 | KoperKoper | - | Partizan BelgradePartizan Belg |
| 20 Jun 22 | r03 | GoricaGorica | 5 - 0 | Rudar PljevljaRudar Pljevlj |
| 20 Jun 22 | r03 | Spartak SuboticaSpartak Subot | 1 - 0 | SutjeskaSutjeska |
| 21 Jun 22 | r03 | KilmarnockKilmarnock | 1 - 0 | Queen of SouthQueen of Sout |
| 21 Jun 22 | r03 | Rapid Wien IIRapid Wien II | 2 - 2 | Floridsdorfer ACFloridsdorfer |
| 21 Jun 22 | r03 | HalmstadHalmstad | 1 - 0 | IFK VarnamoIFK Varnamo |
| 21 Jun 22 | r03 | Cherno MoreCherno More | 1 - 2 | Akademija PandevAkademija Pan |
| 21 Jun 22 | r03 | CSKA 1948CSKA 1948 | 4 - 1 | Lokomotiv PlovdivLokomotiv Plo |
| 21 Jun 22 | r03 | PFC Kuban KrasnodarPFC Kuban Kra | 1 - 0 | PFC Dynamo StavropolPFC Dynamo St |
| 21 Jun 22 | r03 | SKU AmstettenSKU Amstetten | 2 - 0 | LASKLASK |
| 21 Jun 22 | r03 | HelsingborgHelsingborg | 2 - 0 | Joenkoeping S.Joenkoeping S |
| 21 Jun 22 | r03 | Napredak KruševacNapredak Kruš | 0 - 3 | CFR Cluj-NapocaCFR Cluj-Napo |
| 21 Jun 22 | r03 | Rapid ViennaRapid Vienna | 2 - 2 | Floridsdorfer ACFloridsdorfer |
| 21 Jun 22 | r03 | Zenit St PetersburgZenit St Pete | 1 - 1 | Nizhny NovgorodNizhny Novgor |
| 21 Jun 22 | r03 | SV HornSV Horn | 3 - 0 | TWL ElektraTWL Elektra |
| 21 Jun 22 | r03 | Javor IvanjicaJavor Ivanjic | 0 - 0 | KolubaraKolubara |
| 21 Jun 22 | r03 | East FifeEast Fife | 1 - 1 | Civil Service StrollersCivil Service |
| 21 Jun 22 | r03 | Strathspey ThistleStrathspey Th | - | Elgin CityElgin City |
| 21 Jun 22 | r03 | AlloaAlloa | 1 - 3 | PartickPartick |
| 21 Jun 22 | r03 | Elgin CityElgin City | 6 - 0 | LossiemouthLossiemouth |
| 21 Jun 22 | r03 | TNSTNS | 5 - 1 | BalaBala |
| 22 Jun 22 | r03 | SPVGG Greuther FürthSPVGG Greuthe | - | Ludogorets RazgradLudogorets Ra |
| 22 Jun 22 | r03 | Olimpija LjubljanaOlimpija Ljub | - | Bačka PalankaBačka Palanka |
| 22 Jun 22 | r03 | Radnički 1923Radnički 1923 | 1 - 0 | Rudar PljevljaRudar Pljevlj |
| 22 Jun 22 | r03 | BreitenrainBreitenrain | - | Yverdon SportYverdon Sport |
| 22 Jun 22 | r03 | Arda KardzhaliArda Kardzhal | 2 - 0 | Septemvri SofiaSeptemvri Sof |
| 22 Jun 22 | r03 | Korona KielceKorona Kielce | 1 - 0 | Radomiak RadomRadomiak Rado |
| 22 Jun 22 | r03 | Zaglebie SosnowiecZaglebie Sosn | 3 - 2 | GKS KatowiceGKS Katowice |
| 22 Jun 22 | r03 | LKS LodzLKS Lodz | 1 - 0 | Resovia RzeszówResovia Rzesz |
| 22 Jun 22 | r03 | Tatran Liptovský MikulášTatran Liptov | 3 - 1 | KosiceKosice |
| 22 Jun 22 | r03 | Lechia GdańskLechia Gdańsk | 1 - 2 | Rakow CzestochowaRakow Czestoc |
| 22 Jun 22 | r03 | KarlsruheKarlsruhe | 2 - 2 | Wehen WiesbadenWehen Wiesbad |
| 22 Jun 22 | r03 | SK TiranaSK Tirana | 0 - 0 | FC HermannstadtFC Hermannsta |
| 22 Jun 22 | r03 | FC BotoșaniFC Botoșani | 4 - 1 | Politehnica IașiPolitehnica I |
| 22 Jun 22 | r03 | Wisla PlockWisla Plock | 1 - 1 | Chojniczanka ChojniceChojniczanka |
| 22 Jun 22 | r03 | FerencvarosFerencvaros | 0 - 3 | Sepsi OSK Sfântu GheorgheSepsi OSK Sfâ |
| 22 Jun 22 | r03 | Levski SofiaLevski Sofia | 2 - 1 | Pirin BlagoevgradPirin Blagoev |
| 22 Jun 22 | r03 | Vysočina JihlavaVysočina Jihl | 1 - 2 | Viktoria ŽižkovViktoria Žižk |
| 22 Jun 22 | r03 | DAC 1904 Dunajská StredaDAC 1904 Duna | 0 - 0 | Slovan BratislavaSlovan Bratis |
| 22 Jun 22 | r03 | Botev VratsaBotev Vratsa | 3 - 0 | Spartak VarnaSpartak Varna |
| 22 Jun 22 | r03 | NK MariborNK Maribor | 2 - 2 | FC Spartak TrnavaFC Spartak Tr |
| 22 Jun 22 | r03 | CukarickiCukaricki | 1 - 1 | Tuzla CityTuzla City |
| 22 Jun 22 | r03 | VojvodinaVojvodina | 3 - 0 | Maritsa PlovdivMaritsa Plovd |
| 22 Jun 22 | r03 | BreitenrainBreitenrain | - | Young BoysYoung Boys |
| 22 Jun 22 | r03 | FC SionFC Sion | 1 - 1 | Neuchâtel XamaxNeuchâtel Xam |
| 22 Jun 22 | r03 | Slaven Belupo KoprivnicaSlaven Belupo | 5 - 0 | SlobodaSloboda |
| 22 Jun 22 | r03 | Napredak KruševacNapredak Kruš | 1 - 3 | NŠ MuraNŠ Mura |
| 22 Jun 22 | r03 | TSV HavelseTSV Havelse | 1 - 3 | HannoverHannover |
| 22 Jun 22 | r03 | Viktoria KölnViktoria Köln | 1 - 3 | ZurichZurich |
| 22 Jun 22 | r03 | HarelbekeHarelbeke | 0 - 3 | WaregemWaregem |
| 22 Jun 22 | r03 | Fortuna DüsseldorfFortuna Düsse | 3 - 1 | MFK RužomberokMFK Ružombero |
| 22 Jun 22 | r03 | VoždovacVoždovac | - | Mladost Novi SadMladost Novi |
| 22 Jun 22 | r03 | IngolstadtIngolstadt | 3 - 1 | FC PipinsriedFC Pipinsried |
| 22 Jun 22 | r03 | Young BoysYoung Boys | - | Yverdon SportYverdon Sport |
| 22 Jun 22 | r03 | Schwarz-Weiß RehdenSchwarz-Weiß | 0 - 2 | MagdeburgMagdeburg |
| 22 Jun 22 | r03 | SV HeimstettenSV Heimstette | 3 - 1 | VfR GarchingVfR Garching |
| 22 Jun 22 | r03 | Olimpija LjubljanaOlimpija Ljub | 2 - 0 | TSC Bačka TopolaTSC Bačka Top |
| 22 Jun 22 | r03 | Novi PazarNovi Pazar | 2 - 0 | DečićDečić |
| 23 Jun 22 | r03 | CF AmericaCF America | 5 - 2 | LeonLeon |
| 23 Jun 22 | r03 | HamiltonHamilton | 3 - 0 | LarneLarne |
| 23 Jun 22 | r03 | Cherno MoreCherno More | 1 - 2 | Hebar PazardzhikHebar Pazardz |
| 23 Jun 22 | r03 | SKA-KhabarovskSKA-Khabarovs | 3 - 0 | Shinnik YaroslavlShinnik Yaros |
| 23 Jun 22 | r03 | PetrolulPetrolul | 2 - 1 | Dinamo-Auto TiraspolDinamo-Auto T |
| 23 Jun 22 | r03 | Lech PoznanLech Poznan | 0 - 1 | Pogon SzczecinPogon Szczeci |
| 23 Jun 22 | r03 | Slavia SofiaSlavia Sofia | 1 - 1 | MontanaMontana |
| 23 Jun 22 | r03 | GoricaGorica | 3 - 1 | Borac Banja LukaBorac Banja L |
| 23 Jun 22 | r03 | FK RostovFK Rostov | 2 - 0 | Fakel VoronezhFakel Voronez |
| 23 Jun 22 | r03 | SV KapfenbergSV Kapfenberg | 2 - 2 | Arges PitestiArges Pitesti |
| 23 Jun 22 | r03 | Nurnberg IINurnberg II | 1 - 0 | Chemie LeipzigChemie Leipzi |
| 23 Jun 22 | r03 | Radnik SurdulicaRadnik Surdul | 2 - 2 | Buducnost PodgoricaBuducnost Pod |
| 23 Jun 22 | r03 | NK LokomotivaNK Lokomotiva | 1 - 1 | CeljeCelje |
| 23 Jun 22 | r03 | AyrAyr | 1 - 1 | DumbartonDumbarton |
| 24 Jun 22 | r03 | Neftekhimik NizhnekamskNeftekhimik N | 1 - 2 | Torpedo MoscowTorpedo Mosco |
| 24 Jun 22 | r03 | Piast GliwicePiast Gliwice | 1 - 1 | Sandecja Nowy SaczSandecja Nowy |
| 24 Jun 22 | r03 | WesterloWesterlo | 6 - 2 | GentGent |
| 24 Jun 22 | r03 | Holstein Kiel IIHolstein Kiel | 1 - 3 | WiedenbrückWiedenbrück |
| 24 Jun 22 | r03 | GrasshoppersGrasshoppers | 1 - 5 | SchaffhausenSchaffhausen |
| 24 Jun 22 | r03 | FK Rubin KazanFK Rubin Kaza | 5 - 0 | KAMAZ Naberezhnye ChelnyKAMAZ Naberez |
| 24 Jun 22 | r03 | VaduzVaduz | 0 - 2 | Freiburg IIFreiburg II |
| 24 Jun 22 | r03 | Fortuna Düsseldorf IIFortuna Düsse | 0 - 5 | Dortmund IIDortmund II |
| 24 Jun 22 | r03 | Lokomotiv PlovdivLokomotiv Plo | 1 - 1 | Septemvri SofiaSeptemvri Sof |
| 24 Jun 22 | r03 | Legia WarsawLegia Warsaw | 0 - 1 | Sepsi OSK Sfântu GheorgheSepsi OSK Sfâ |
| 24 Jun 22 | r03  | Mlada BoleslavMlada Bolesla | 3 - 3 | LiberecLiberec |
| 24 Jun 22 | r03 | SKU AmstettenSKU Amstetten | 2 - 4 | FC Trenkwalder AdmiraFC Trenkwalde |
| 24 Jun 22 | r03 | Lask Juniors LinzLask Juniors | 1 - 0 | Austria Vienna (Am)Austria Vienn |
| 24 Jun 22 | r03 | Torpedo MoscowTorpedo Mosco | 2 - 2 | Tekstilshchik IvanovoTekstilshchik |
| 24 Jun 22 | r03 | Zaglebie LubinZaglebie Lubi | 1 - 2 | Miedz LegnicaMiedz Legnica |
| 24 Jun 22 | r03 | Partizan BelgradePartizan Belg | 0 - 1 | CFR Cluj-NapocaCFR Cluj-Napo |
| 24 Jun 22 | r03 | NK BravoNK Bravo | 1 - 2 | Crvena ZvezdaCrvena Zvezda |
| 24 Jun 22 | r03 | Uta AradUta Arad | 5 - 1 | Maritsa PlovdivMaritsa Plovd |
| 24 Jun 22 | r03 | Sturm GrazSturm Graz | 3 - 2 | NŠ MuraNŠ Mura |
| 24 Jun 22 | r03 | SV Josko RiedSV Josko Ried | 2 - 0 | OlympiakosOlympiakos |
| 24 Jun 22 | r03 | SV SalzburgSV Salzburg | 2 - 1 | CSKA SofiaCSKA Sofia |
| 24 Jun 22 | r03 | Stuttgart IIStuttgart II | 3 - 2 | Augsburg IIAugsburg II |
| 24 Jun 22 | r03 | CSKA MoscowCSKA Moscow | 0 - 2 | Veles MoscowVeles Moscow |
| 24 Jun 22 | r03 | Bruck-LeithaBruck-Leitha | 1 - 2 | SV LafnitzSV Lafnitz |
| 24 Jun 22 | r03 | SV HornSV Horn | 2 - 2 | Wiener NeustadtWiener Neusta |
| 24 Jun 22 | r03 | VfB AuerbachVfB Auerbach | 1 - 3 | Dynamo DresdenDynamo Dresde |
| 24 Jun 22 | r03 | HarelbekeHarelbeke | 5 - 3 | KV OostendeKV Oostende |
| 24 Jun 22 | r03 | Kickers EmdenKickers Emden | 0 - 5 | Rot-Weiss EssenRot-Weiss Ess |
| 24 Jun 22 | r03 | FalkirkFalkirk | 1 - 4 | KilmarnockKilmarnock |
| 24 Jun 22 | r03 | Kelty HeartsKelty Hearts | 0 - 1 | PartickPartick |
| 25 Jun 22 | r03 | Spartak MoscowSpartak Mosco | 2 - 2 | Alania VladikavkazAlania Vladik |
| 25 Jun 22 | r03 | TSC Bačka TopolaTSC Bačka Top | 2 - 1 | ŠibenikŠibenik |
| 25 Jun 22 | r03 | MonacoMonaco | 1 - 0 | Cercle BruggeCercle Brugge |
| 25 Jun 22 | r03 | Botev VratsaBotev Vratsa | 2 - 1 | Minyor PernikMinyor Pernik |
| 25 Jun 22 | r03 | Austria LustenauAustria Luste | 0 - 4 | FC WilFC Wil |
| 25 Jun 22 | r03 | LKS LodzLKS Lodz | 0 - 1 | Stal RzeszówStal Rzeszów |
| 25 Jun 22 | r03 | Chindia TârgovișteChindia Târgo | 0 - 0 | CS MioveniCS Mioveni |
| 25 Jun 22 | r03 | MSK ZilinaMSK Zilina | 3 - 0 | KarvinaKarvina |
| 25 Jun 22 | r03 | Paksi FCPaksi FC | 3 - 2 | SiófokSiófok |
| 25 Jun 22 | r03 | Sparta PragueSparta Prague | 2 - 1 | Dukla PrahaDukla Praha |
| 25 Jun 22 | r03 | TepliceTeplice | 2 - 0 | Ústí nad LabemÚstí nad Labe |
| 25 Jun 22 | r03 | SlovackoSlovacko | 2 - 0 | TrencinTrencin |
| 25 Jun 22 | r03 | Jagiellonia BialystokJagiellonia B | 1 - 0 | Warta PoznańWarta Poznań |
| 25 Jun 22 | r03 | TřinecTřinec | 0 - 3 | Dukla Banská BystricaDukla Banská |
| 25 Jun 22 | r03 | Ruch ChorzowRuch Chorzow | 3 - 0 | Odra OpoleOdra Opole |
| 25 Jun 22 | r03 | Zaglebie SosnowiecZaglebie Sosn | - | Podbeskidzie Bielsko-BialPodbeskidzie |
| 25 Jun 22 | r03 | Wisla PlockWisla Plock | - | Lechia GdańskLechia Gdańsk |
| 25 Jun 22 | r03 | LíšeňLíšeň | 0 - 2 | SkalicaSkalica |
| 25 Jun 22 | r03 | KomárnoKomárno | 1 - 2 | FK PohronieFK Pohronie |
| 25 Jun 22 | r03 | Wisla KrakowWisla Krakow | 2 - 0 | Stal MielecStal Mielec |
| 25 Jun 22 | r03 | Widzew LodzWidzew Lodz | 1 - 1 | Tychy 71Tychy 71 |
| 25 Jun 22 | r03 | GKS KatowiceGKS Katowice | 1 - 0 | Górnik PolkowiceGórnik Polkow |
| 25 Jun 22 | r03 | Korona KielceKorona Kielce | 0 - 1 | Skra CzęstochowaSkra Częstoch |
| 25 Jun 22 | r03 | Mlada BoleslavMlada Bolesla | - | Hradec KrálovéHradec Králov |
| 25 Jun 22 | r03 | Hradec KrálovéHradec Králov | 5 - 1 | PribramPribram |
| 25 Jun 22 | r03 | Gazovik OrenburgGazovik Orenb | 2 - 2 | Dinamo-Auto TiraspolDinamo-Auto T |
| 25 Jun 22 | r03 | SC VerlSC Verl | 2 - 2 | PaderbornPaderborn |
| 25 Jun 22 | r03 | Wuppertaler SVWuppertaler S | 0 - 2 | BochumBochum |
| 25 Jun 22 | r03 | HannoverHannover | - | DuisburgDuisburg |
| 25 Jun 22 | r03 | VSG AltglienickeVSG Altglieni | 1 - 1 | Hertha IIHertha II |
| 25 Jun 22 | r03 | Holstein KielHolstein Kiel | 2 - 0 | St PauliSt Pauli |
| 25 Jun 22 | r03 | ProstějovProstějov | 3 - 0 | DubnicaDubnica |
| 25 Jun 22 | r03 | Tasmania BerlinTasmania Berl | 0 - 9 | Berliner AK 07Berliner AK 0 |
| 25 Jun 22 | r03 | AyrAyr | 2 - 1 | StranraerStranraer |
| 25 Jun 22 | r03 | FC MidtjyllandFC Midtjyllan | 3 - 2 | Odense BKOdense BK |
| 25 Jun 22 | r03 | FK Železiarne PodbrezováFK Železiarne | 4 - 2 | Zbrojovka BrnoZbrojovka Brn |
| 25 Jun 22 | r03 | AGF AarhusAGF Aarhus | 2 - 2 | AaBAaB |
| 25 Jun 22 | r03 | Cove RangersCove Rangers | 0 - 2 | DunfermlineDunfermline |
| 25 Jun 22 | r03 | FC DordrechtFC Dordrecht | - | Lierse KempenzonenLierse Kempen |
| 25 Jun 22 | r03 | VfR GarchingVfR Garching | 2 - 3 | FC PipinsriedFC Pipinsried |
| 25 Jun 22 | r03 | Needham MarketNeedham Marke | - | IpswichIpswich |
| 25 Jun 22 | r03 | Sparta Prague BSparta Prague | 0 - 3 | ChrudimChrudim |
| 25 Jun 22 | r03 | Mainz IIMainz II | - | TuS KoblenzTuS Koblenz |
| 25 Jun 22 | r03 | Munich 1860Munich 1860 | 0 - 4 | KarlsruheKarlsruhe |
| 25 Jun 22 | r03 | FC LieferingFC Liefering | 6 - 0 | SK Vorwarts SteyrSK Vorwarts S |
| 25 Jun 22 | r03 | SV MeppenSV Meppen | 0 - 1 | Schalke 04 IISchalke 04 II |
| 25 Jun 22 | r03 | ElversbergElversberg | 2 - 1 | Mgladbach IIMgladbach II |
| 25 Jun 22 | r03 | MontroseMontrose | 4 - 3 | Formartine UnitedFormartine Un |
| 25 Jun 22 | r03 | MagdeburgMagdeburg | 1 - 2 | Viktoria BerlinViktoria Berl |
| 25 Jun 22 | r03 | BrøndbyBrøndby | 1 - 1 | Hvidovre IFHvidovre IF |
| 25 Jun 22 | r03 | Elgin CityElgin City | 2 - 0 | FraserburghFraserburgh |
| 25 Jun 22 | r03 | Fortuna KölnFortuna Köln | 0 - 1 | BocholtBocholt |
| 25 Jun 22 | r03 | PribramPribram | 0 - 7 | Mlada BoleslavMlada Bolesla |
| 25 Jun 22 | r03 | Annan AthleticAnnan Athleti | 2 - 2 | MortonMorton |
| 25 Jun 22 | r03 | Berwick RangersBerwick Range | 1 - 1 | StenhousemuirStenhousemuir |
| 25 Jun 22 | r03 | Brechin CityBrechin City | 1 - 2 | ArbroathArbroath |
| 25 Jun 22 | r03 | Wuerzburger KickersWuerzburger K | 1 - 2 | Kickers OffenbachKickers Offen |
| 25 Jun 22 | r03 | SAK KlagenfurtSAK Klagenfur | 1 - 4 | OsijekOsijek |
| 25 Jun 22 | r03 | LinfieldLinfield | 0 - 0 | NewtownNewtown |
| 25 Jun 22 | r03 | ThunThun | 3 - 3 | St. GallenSt. Gallen |
| 25 Jun 22 | r03 | Werder BremenWerder Bremen | 1 - 3 | OldenburgOldenburg |
| 25 Jun 22 | r03 | KortrijkKortrijk | 3 - 1 | MechelenMechelen |
| 25 Jun 22 | r03 | Botev PlovdivBotev Plovdiv | 2 - 1 | Metalist KharkivMetalist Khar |
| 25 Jun 22 | r03 | FC SionFC Sion | 1 - 2 | ServetteServette |
| 25 Jun 22 | r03 | Worksop TownWorksop Town | 1 - 3 | BarnsleyBarnsley |
| 25 Jun 22 | r03 | SC Rheindorf AltachSC Rheindorf | 0 - 1 | LucerneLucerne |
| 25 Jun 22 | r03 | SKN St. PoltenSKN St. Polte | 4 - 2 | Austria ViennaAustria Vienn |
| 25 Jun 22 | r03 | BalaBala | 2 - 1 | CliftonvilleCliftonville |
| 25 Jun 22 | r03 | FC BaselFC Basel | 3 - 2 | SPVGG Greuther FürthSPVGG Greuthe |
| 25 Jun 22 | r03 | Caledonian BravesCaledonian Br | 1 - 0 | DumbartonDumbarton |
| 25 Jun 22 | r03 | The SpartansThe Spartans | 2 - 1 | East FifeEast Fife |
| 25 Jun 22 | r03 | Cumbernauld ColtsCumbernauld C | 0 - 3 | AlloaAlloa |
| 25 Jun 22 | r03 | Swift HesperangeSwift Hespera | 2 - 2 | FC SaarbrückenFC Saarbrücke |
| 25 Jun 22 | r03 | Buckie ThistleBuckie Thistl | 1 - 2 | AberdeenAberdeen |
| 25 Jun 22 | r03 | Újpest FCÚjpest FC | 1 - 1 | ŠamorínŠamorín |
| 25 Jun 22 | r03 | NiecieczaNieciecza | 1 - 2 | Tatran Liptovský MikulášTatran Liptov |
| 25 Jun 22 | r03 | CSKA 1948CSKA 1948 | 3 - 0 | Lokomotiv SofiaLokomotiv Sof |
| 25 Jun 22 | r03 | Preußen MünsterPreußen Münst | 6 - 0 | KFC Uerdingen 05KFC Uerdingen |
| 25 Jun 22 | r03 | VoždovacVoždovac | 1 - 3 | Javor IvanjicaJavor Ivanjic |
| 25 Jun 22 | r03 | FC HermannstadtFC Hermannsta | 2 - 0 | ShkupiShkupi |
| 25 Jun 22 | r03 | Hradec KrálovéHradec Králov | 4 - 1 | LiberecLiberec |
| 25 Jun 22 | r03 | Rapid ViennaRapid Vienna | 3 - 1 | Neusiedl am SeeNeusiedl am S |
| 25 Jun 22 | r03 | Pirin BlagoevgradPirin Blagoev | 0 - 0 | Spartak VarnaSpartak Varna |
| 25 Jun 22 | r03 | Resovia RzeszówResovia Rzesz | 1 - 2 | MFK Zemplín MichalovceMFK Zemplín M |
| 25 Jun 22 | r03 | VasasVasas | 2 - 2 | Kisvárda FCKisvárda FC |
| 25 Jun 22 | r03 | PardubicePardubice | 3 - 1 | Vysočina JihlavaVysočina Jihl |
| 25 Jun 22 | r03 | FerencvarosFerencvaros | 3 - 0 | Ludogorets RazgradLudogorets Ra |
| 25 Jun 22 | r03 | Levski SofiaLevski Sofia | 3 - 1 | Akademija PandevAkademija Pan |
| 25 Jun 22 | r03 | LASKLASK | - | Cracovia KrakowCracovia Krak |
| 25 Jun 22 | r03 | Schwaben AugsburgSchwaben Augs | 2 - 2 | TSV Rain am LechTSV Rain am L |
| 25 Jun 22 | r03 | WiltzWiltz | 1 - 2 | RFC SeraingRFC Seraing |
| 25 Jun 22 | r03 | Qarabag FKQarabag FK | 4 - 0 | FC BotoșaniFC Botoșani |
| 25 Jun 22 | r03 | AnderlechtAnderlecht | 0 - 1 | St.TruidenSt.Truiden |
| 25 Jun 22 | r03 | FC Lausanne-SportFC Lausanne-S | 1 - 0 | Stade Lausanne OuchyStade Lausann |
| 25 Jun 22 | r03 | NK MariborNK Maribor | 1 - 1 | Tuzla CityTuzla City |
| 25 Jun 22 | r03 | PécsPécs | - | Slaven Belupo KoprivnicaSlaven Belupo |
| 25 Jun 22 | r03 | Fortuna DüsseldorfFortuna Düsse | 1 - 2 | OlympiakosOlympiakos |
| 25 Jun 22 | r03 | Olimpija LjubljanaOlimpija Ljub | 2 - 3 | CukarickiCukaricki |
| 25 Jun 22 | r03 | RadomljeRadomlje | 3 - 5 | Radnički NišRadnički Niš |
| 25 Jun 22 | r03 | NK VaraždinNK Varaždin | 2 - 1 | HNK GoricaHNK Gorica |
| 25 Jun 22 | r03 | Hajduk SplitHajduk Split | 0 - 2 | CFR Cluj-NapocaCFR Cluj-Napo |
| 25 Jun 22 | r03 | Peterhead FCPeterhead FC | 1 - 1 | Inverurie Loco WorksInverurie Loc |
| 25 Jun 22 | r03 | Racing FC Union LuxembourRacing FC Uni | 1 - 3 | CharleroiCharleroi |
| 25 Jun 22 | r03 | Mladost Novi SadMladost Novi | 0 - 0 | Spartak SuboticaSpartak Subot |
| 25 Jun 22 | r03 | PFC SochiPFC Sochi | 1 - 1 | Zenit St PetersburgZenit St Pete |
| 25 Jun 22 | r03 | FC AarauFC Aarau | 3 - 1 | SC KriensSC Kriens |
| 25 Jun 22 | r03 | KoperKoper | 2 - 0 | NK Istra 1961NK Istra 1961 |
| 25 Jun 22 | r03 | Mladost LučaniMladost Lučan | 0 - 3 | DečićDečić |
| 26 Jun 22 | r03 | Rukh LvivRukh Lviv | 1 - 2 | PrykarpattiaPrykarpattia |
| 26 Jun 22 | r03 | Radnički 1923Radnički 1923 | 3 - 0 | Maritsa PlovdivMaritsa Plovd |
| 26 Jun 22 | r03 | Rakow CzestochowaRakow Czestoc | 5 - 1 | Chojniczanka ChojniceChojniczanka |
| 26 Jun 22 | r03 | SV BabelsbergSV Babelsberg | 1 - 5 | Tasmania BerlinTasmania Berl |
| 26 Jun 22 | r03 | Ural S.RUral S.R | - | Akron TolyattiAkron Tolyatt |
| 26 Jun 22 | r03 | Randers FCRanders FC | 6 - 2 | FC HelsingoerFC Helsingoer |
| 26 Jun 22 | r03 | AueAue | 4 - 0 | Berliner AK 07Berliner AK 0 |
| 26 Jun 22 | r03 | FC NordsjællandFC Nordsjælla | 3 - 0 | KøgeKøge |
| 26 Jun 22 | r03 | TNSTNS | 2 - 1 | CliftonvilleCliftonville |
| 26 Jun 22 | r03 | FC Anzhi MakhachkalaFC Anzhi Makh | 3 - 0 | PFC Spartak NalchikPFC Spartak N |
| 26 Jun 22 | r03 | Lok. MoscowLok. Moscow | 2 - 1 | Veles MoscowVeles Moscow |
| 26 Jun 22 | r03 | FC Krasnodar-2FC Krasnodar- | 2 - 0 | Chayka PeschanokopskoyeChayka Pescha |
| 26 Jun 22 | r03  | Ludogorets RazgradLudogorets Ra | 3 - 0 | NurnbergNurnberg |
| 26 Jun 22 | r03 | Yverdon SportYverdon Sport | 1 - 1 | Dynamo KievDynamo Kiev |
| 26 Jun 22 | r03 | Universitatea CraiovaUniversitatea | 4 - 1 | BielefeldBielefeld |
| 26 Jun 22 | r03 | KoperKoper | 0 - 0 | VojvodinaVojvodina |
| 26 Jun 22 | r03 | Dinamo ZagrebDinamo Zagreb | 3 - 0 | Shkendija 79Shkendija 79 |
| 26 Jun 22 | r03 | Radnik SurdulicaRadnik Surdul | 1 - 4 | SutjeskaSutjeska |
| 26 Jun 22 | r03 | CeljeCelje | 0 - 0 | Borac Banja LukaBorac Banja L |
| 27 Jun 22 | r03 | SV KapfenbergSV Kapfenberg | 3 - 3 | FC U Craiova 1948FC U Craiova |
| 27 Jun 22 | r03 | Universitatea ClujUniversitatea | 0 - 2 | Napredak KruševacNapredak Kruš |
| 27 Jun 22 | r03 | SønderjyskeSønderjyske | 1 - 2 | FredericiaFredericia |
| 27 Jun 22 | r03 | FC CopenhagenFC Copenhagen | 0 - 2 | Silkeborg IFSilkeborg IF |
| 27 Jun 22 | r03 | Sepsi OSK Sfântu GheorgheSepsi OSK Sfâ | 4 - 0 | CSKA SofiaCSKA Sofia |
| 27 Jun 22 | r03 | Terek GroznyTerek Grozny | - | FC Zenit PenzaFC Zenit Penz |
| 27 Jun 22 | r03 | Neftekhimik NizhnekamskNeftekhimik N | 2 - 2 | Shinnik YaroslavlShinnik Yaros |
| 27 Jun 22 | r03 | Khimki FKKhimki FK | - | Tekstilshchik IvanovoTekstilshchik |
| 27 Jun 22 | r03 | Slavia SofiaSlavia Sofia | 1 - 0 | Arda KardzhaliArda Kardzhal |
| 27 Jun 22 | r03 | Universitatea ClujUniversitatea | - | VojvodinaVojvodina |
| 27 Jun 22 | r03 | SV KapfenbergSV Kapfenberg | - | Universitatea CraiovaUniversitatea |
| 27 Jun 22 | r03 | DomzaleDomzale | 1 - 1 | Crvena ZvezdaCrvena Zvezda |
| 27 Jun 22 | r03 | VojvodinaVojvodina | 2 - 1 | Uta AradUta Arad |
| 27 Jun 22 | r03 | OlympiakosOlympiakos | 0 - 0 | Cracovia KrakowCracovia Krak |
| 27 Jun 22 | r03 | Buducnost PodgoricaBuducnost Pod | 2 - 2 | Novi PazarNovi Pazar |
| 27 Jun 22 | r03 | CrusadersCrusaders | 0 - 3 | St MirrenSt Mirren |
| 28 Jun 22 | r03 | LuganoLugano | - | KaiserslauternKaiserslauter |
| 28 Jun 22 | r03 | Zvijezda 09Zvijezda 09 | 0 - 1 | KolubaraKolubara |
| 28 Jun 22 | r03 | KilmarnockKilmarnock | 2 - 2 | Lincoln Red ImpsLincoln Red I |
| 28 Jun 22 | r03 | LKS LodzLKS Lodz | 1 - 1 | Stal MielecStal Mielec |
| 28 Jun 22 | r03 | Slavia SofiaSlavia Sofia | 1 - 2 | Hebar PazardzhikHebar Pazardz |
| 28 Jun 22 | r03 | Bohemians 1905Bohemians 190 | 5 - 3 | TáborskoTáborsko |
| 28 Jun 22 | r03 | Lech PoznanLech Poznan | 2 - 1 | Jagiellonia BialystokJagiellonia B |
| 28 Jun 22 | r03 | CSKA SofiaCSKA Sofia | - | FerencvarosFerencvaros |
| 28 Jun 22 | r03 | FK Rubin KazanFK Rubin Kaza | - | Krylya Sovetov SamaraKrylya Soveto |
| 28 Jun 22 | r03 | BraunschweigBraunschweig | 1 - 0 | Freiburg IIFreiburg II |
| 28 Jun 22 | r03 | Piast GliwicePiast Gliwice | 2 - 0 | Resovia RzeszówResovia Rzesz |
| 28 Jun 22 | r03 | Young BoysYoung Boys | 2 - 1 | Neuchâtel XamaxNeuchâtel Xam |
| 28 Jun 22 | r03 | NK BravoNK Bravo | 2 - 1 | CukarickiCukaricki |
| 28 Jun 22 | r03 | Arka GdyniaArka Gdynia | 0 - 2 | Wisla PlockWisla Plock |
| 28 Jun 22 | r03 | Gornik ZabrzeGornik Zabrze | 2 - 2 | Tatran Liptovský MikulášTatran Liptov |
| 28 Jun 22 | r03 | Viktoria PlzenViktoria Plze | 3 - 1 | Slovan BratislavaSlovan Bratis |
| 28 Jun 22 | r03 | Volgar AstrakhanVolgar Astrak | 1 - 1 | Torpedo MoscowTorpedo Mosco |
| 28 Jun 22 | r03 | BeroeBeroe | 1 - 0 | Yantra GabrovoYantra Gabrov |
| 28 Jun 22 | r03 | SlovackoSlovacko | 1 - 0 | ViOn Zlaté MoravceViOn Zlaté Mo |
| 28 Jun 22 | r03 | FerencvarosFerencvaros | 4 - 1 | KarlsruheKarlsruhe |
| 28 Jun 22 | r03 | KaiserslauternKaiserslauter | 3 - 4 | LuganoLugano |
| 28 Jun 22 | r03 | Radnički NišRadnički Niš | 6 - 0 | Maritsa PlovdivMaritsa Plovd |
| 28 Jun 22 | r03 | Dortmund IIDortmund II | 1 - 1 | Preußen MünsterPreußen Münst |
| 28 Jun 22 | r03 | FC KrasnodarFC Krasnodar | 2 - 0 | FK RostovFK Rostov |
| 28 Jun 22 | r03 | Partizan BelgradePartizan Belg | 3 - 0 | FC Spartak TrnavaFC Spartak Tr |
| 28 Jun 22 | r03 | Radnički 1923Radnički 1923 | 0 - 1 | RijekaRijeka |
| 28 Jun 22 | r03 | TraiskirchenTraiskirchen | 0 - 3 | Austria ViennaAustria Vienn |
| 28 Jun 22 | r03 | Marchfeld DonauauenMarchfeld Don | 0 - 1 | Floridsdorfer ACFloridsdorfer |
| 28 Jun 22 | r03 | VfL OldenburgVfL Oldenburg | 3 - 2 | OldenburgOldenburg |
| 28 Jun 22 | r03 | Mladost Novi SadMladost Novi | 1 - 0 | SutjeskaSutjeska |
| 28 Jun 22 | r03 | FC Trenkwalder AdmiraFC Trenkwalde | 0 - 4 | Wiener SCWiener SC |
| 28 Jun 22 | r03 | Bruck-LeithaBruck-Leitha | 1 - 2 | SV HornSV Horn |
| 28 Jun 22 | r03 | VaduzVaduz | 1 - 1 | FC WinterthurFC Winterthur |
| 28 Jun 22 | r03 | AugsburgAugsburg | 5 - 0 | Schwaben AugsburgSchwaben Augs |
| 28 Jun 22 | r03 | Rapid Wien IIRapid Wien II | 2 - 5 | StripfingStripfing |
| 28 Jun 22 | r03 | Marchfeld DonauauenMarchfeld Don | - | SV HornSV Horn |
| 28 Jun 22 | r03 | Mladost LučaniMladost Lučan | 2 - 1 | VoždovacVoždovac |
| 28 Jun 22 | r03 | Javor IvanjicaJavor Ivanjic | 3 - 2 | DečićDečić |
| 28 Jun 22 | r03 | StenhousemuirStenhousemuir | 0 - 1 | MortonMorton |
| 28 Jun 22 | r03 | ForfarForfar | 0 - 6 | DunfermlineDunfermline |
| 28 Jun 22 | r03 | Banks O Dee F.C.Banks O Dee F | - | Cove RangersCove Rangers |
| 28 Jun 22 | r03 | KeithKeith | 0 - 5 | Elgin CityElgin City |
| 28 Jun 22 | r03 | AlloaAlloa | 4 - 1 | Stirling AlbionStirling Albi |
| 28 Jun 22 | r03 | FalkirkFalkirk | 1 - 0 | StranraerStranraer |
| 28 Jun 22 | r03 | Longford TownLongford Town | - | BoltonBolton |
| 28 Jun 22 | r03 | Melksham TownMelksham Town | 0 - 3 | Forest Green RoversForest Green |
| 29 Jun 22 | r03 | Chayka PeschanokopskoyeChayka Pescha | - | FC Forte TaganrogFC Forte Taga |
| 29 Jun 22 | r03 | Kispest HonvedKispest Honve | - | KazincbarcikaKazincbarcika |
| 29 Jun 22 | r03 | TSV HartbergTSV Hartberg | 1 - 0 | Universitatea ClujUniversitatea |
| 29 Jun 22 | r03 | FC U Craiova 1948FC U Craiova | 1 - 2 | AEK LarnacaAEK Larnaca |
| 29 Jun 22 | r03 | Zalaegerszegi TEZalaegerszegi | 1 - 2 | Borac Banja LukaBorac Banja L |
| 29 Jun 22 | r03 | Sigma OlomoucSigma Olomouc | 2 - 3 | VyškovVyškov |
| 29 Jun 22 | r03 | LiberecLiberec | 3 - 1 | VlašimVlašim |
| 29 Jun 22 | r03 | TepliceTeplice | 2 - 3 | VarnsdorfVarnsdorf |
| 29 Jun 22 | r03 | Skra CzęstochowaSkra Częstoch | 2 - 0 | Znicz PruszkówZnicz Pruszkó |
| 29 Jun 22 | r03 | HibernianHibernian | 2 - 0 | HartlepoolHartlepool |
| 29 Jun 22 | r03 | Holstein KielHolstein Kiel | 2 - 2 | Qarabag FKQarabag FK |
| 29 Jun 22 | r03 | LarneLarne | 2 - 0 | TNSTNS |
| 29 Jun 22 | r03 | StandardStandard | 0 - 2 | St.TruidenSt.Truiden |
| 29 Jun 22 | r03 | SV SalzburgSV Salzburg | 3 - 2 | Legia WarsawLegia Warsaw |
| 29 Jun 22 | r03 | Legia WarsawLegia Warsaw | 3 - 2 | SV SalzburgSV Salzburg |
| 29 Jun 22 | r03 | FC HermannstadtFC Hermannsta | 2 - 1 | Zira FKZira FK |
| 29 Jun 22 | r03 | Club BruggeClub Brugge | 1 - 1 | Lierse KempenzonenLierse Kempen |
| 29 Jun 22 | r03 | Cherno MoreCherno More | 2 - 1 | SozopolSozopol |
| 29 Jun 22 | r03 | Spartak MoscowSpartak Mosco | 3 - 2 | Baltika KaliningradBaltika Kalin |
| 29 Jun 22 | r03 | Dynamo DresdenDynamo Dresde | 0 - 1 | FC HeidenheimFC Heidenheim |
| 29 Jun 22 | r03 | CSKA 1948CSKA 1948 | 3 - 1 | Akademija PandevAkademija Pan |
| 29 Jun 22 | r03 | PetrolulPetrolul | 2 - 1 | Al-MarkhiyaAl-Markhiya |
| 29 Jun 22 | r03 | CsikszeredaCsikszereda | 0 - 1 | Chindia TârgovișteChindia Târgo |
| 29 Jun 22 | r03 | PúchovPúchov | 2 - 3 | TřinecTřinec |
| 29 Jun 22 | r03 | FK Železiarne PodbrezováFK Železiarne | 1 - 2 | KomárnoKomárno |
| 29 Jun 22 | r03 | Queens ParkQueens Park | - | NK LokomotivaNK Lokomotiva |
| 29 Jun 22 | r03 | Gornik LecznaGornik Leczna | 1 - 1 | Puszcza NiepołomicePuszcza Niepo |
| 29 Jun 22 | r03 | Farul ConstantaFarul Constan | 0 - 0 | CS MioveniCS Mioveni |
| 29 Jun 22 | r03 | Levski SofiaLevski Sofia | 2 - 1 | Lokomotiv SofiaLokomotiv Sof |
| 29 Jun 22 | r03 | Stade Lausanne OuchyStade Lausann | 1 - 2 | ServetteServette |
| 29 Jun 22 | r03 | JastrzębieJastrzębie | 0 - 3 | Ruch ChorzowRuch Chorzow |
| 29 Jun 22 | r03 | Banik OstravaBanik Ostrava | 1 - 1 | ZlínZlín |
| 29 Jun 22 | r03 | PardubicePardubice | 2 - 1 | PribramPribram |
| 29 Jun 22 | r03 | Steaua BucurestiSteaua Bucure | 6 - 0 | Sfântul Gheorghe SuruceniSfântul Gheor |
| 29 Jun 22 | r03 | CukarickiCukaricki | 1 - 0 | Slask WroclawSlask Wroclaw |
| 29 Jun 22 | r03 | Mezőkövesdi SEMezőkövesdi S | 5 - 4 | MTK HungariaMTK Hungaria |
| 29 Jun 22 | r03 | VasasVasas | 3 - 0 | MFK Zemplín MichalovceMFK Zemplín M |
| 29 Jun 22 | r03 | LíšeňLíšeň | - | Slovan BratislavaSlovan Bratis |
| 29 Jun 22 | r03 | Rapid ViennaRapid Vienna | 5 - 2 | SV LafnitzSV Lafnitz |
| 29 Jun 22 | r03 | PFC Kuban KrasnodarPFC Kuban Kra | 1 - 0 | FC Druzhba MaykopFC Druzhba Ma |
| 29 Jun 22 | r03 | FC Chernomorets NovorossiFC Chernomore | 1 - 3 | Chayka PeschanokopskoyeChayka Pescha |
| 29 Jun 22 | r03 | Budafoki MTEBudafoki MTE | 1 - 1 | Dukla Banská BystricaDukla Banská |
| 29 Jun 22 | r03 | Arda KardzhaliArda Kardzhal | 1 - 2 | Vitosha BistritsaVitosha Bistr |
| 29 Jun 22 | r03 | Botev VratsaBotev Vratsa | 0 - 1 | Spartak PlevenSpartak Pleve |
| 29 Jun 22 | r03 | SKN St. PoltenSKN St. Polte | 3 - 2 | Rapid BucurestiRapid Bucures |
| 29 Jun 22 | r03 | HamburgHamburg | 2 - 2 | Hajduk SplitHajduk Split |
| 29 Jun 22 | r03 | Yverdon SportYverdon Sport | 1 - 2 | FC SionFC Sion |
| 29 Jun 22 | r03 | Slavia PragueSlavia Prague | 1 - 1 | OlympiakosOlympiakos |
| 29 Jun 22 | r03 | NiecieczaNieciecza | 5 - 1 | KarvinaKarvina |
| 29 Jun 22 | r03 | Waldhof MannheimWaldhof Mannh | 2 - 0 | FC AarauFC Aarau |
| 29 Jun 22 | r03 | Viktoria BerlinViktoria Berl | 1 - 3 | Union BerlinUnion Berlin |
| 29 Jun 22 | r03 | GoricaGorica | 0 - 0 | Tabor SežanaTabor Sežana |
| 29 Jun 22 | r03 | TSV HavelseTSV Havelse | 1 - 4 | OsnabrueckOsnabrueck |
| 29 Jun 22 | r03 | MonacoMonaco | 1 - 1 | St. GallenSt. Gallen |
| 29 Jun 22 | r03 | WaregemWaregem | 1 - 1 | CharleroiCharleroi |
| 29 Jun 22 | r03 | NK MariborNK Maribor | 1 - 1 | PartizaniPartizani |
| 29 Jun 22 | r03 | Cherno MoreCherno More | 3 - 1 | Etar Veliko TarnovoEtar Veliko T |
| 29 Jun 22 | r03 | Sparta Prague BSparta Prague | - | FC BW LinzFC BW Linz |
| 29 Jun 22 | r03 | Qarabag FKQarabag FK | 1 - 1 | Universitatea CraiovaUniversitatea |
| 29 Jun 22 | r03 | CSKA MoscowCSKA Moscow | 0 - 3 | Zenit St PetersburgZenit St Pete |
| 29 Jun 22 | r03 | Go Ahead EaglesGo Ahead Eagl | 0 - 4 | PAOKPAOK |
| 29 Jun 22 | r03 | FC Lausanne-SportFC Lausanne-S | 2 - 0 | Dynamo KievDynamo Kiev |
| 29 Jun 22 | r03 | ClachnacuddinClachnacuddin | 0 - 10 | Inverness CInverness C |
| 29 Jun 22 | r03 | Raith RvsRaith Rvs | 1 - 2 | Queen of SouthQueen of Sout |
| 30 Jun 22 | r03 | PetrolulPetrolul | - | Al-ShamalAl-Shamal |
| 30 Jun 22 | r03 | Dinamo MoscowDinamo Moscow | 3 - 0 | SKA-KhabarovskSKA-Khabarovs |
| 30 Jun 22 | r03 | Sparta PragueSparta Prague | 3 - 0 | SFC OpavaSFC Opava |
| 30 Jun 22 | r03 | Krylya Sovetov SamaraKrylya Soveto | 0 - 3 | Akron TolyattiAkron Tolyatt |
| 30 Jun 22 | r03 | Radomiak RadomRadomiak Rado | - | Lechia GdańskLechia Gdańsk |
| 30 Jun 22 | r03 | Uta AradUta Arad | - | PartizaniPartizani |
| 30 Jun 22 | r03 | FC MidtjyllandFC Midtjyllan | 2 - 1 | AaBAaB |
| 30 Jun 22 | r03 | FC Mashuk-KMV PyatigorskFC Mashuk-KMV | 0 - 0 | FC Anzhi MakhachkalaFC Anzhi Makh |
| 30 Jun 22 | r03 | FC BaselFC Basel | 3 - 1 | FC BotoșaniFC Botoșani |
| 30 Jun 22 | r03 | Europa FCEuropa FC | 0 - 4 | HeartsHearts |
| 30 Jun 22 | r03 | Uta AradUta Arad | 0 - 0 | Radnički NišRadnički Niš |
| 30 Jun 22 | r03 | LuganoLugano | 0 - 1 | IngolstadtIngolstadt |
| 30 Jun 22 | r03 | Olimpija LjubljanaOlimpija Ljub | 0 - 0 | ŠibenikŠibenik |
| 30 Jun 22 | r03 | Carl Zeiss JenaCarl Zeiss Je | 2 - 2 | RödinghausenRödinghausen |
| 30 Jun 22 | r03 | Botev VratsaBotev Vratsa | 0 - 0 | Apoel NicosiaApoel Nicosia |
| 30 Jun 22 | r03 | SandhausenSandhausen | 3 - 0 | Sepsi OSK Sfântu GheorgheSepsi OSK Sfâ |
| 30 Jun 22 | r03 | DAC 1904 Dunajská StredaDAC 1904 Duna | 1 - 3 | Paksi FCPaksi FC |
| 30 Jun 22 | r03 | KarlsruheKarlsruhe | - | Sepsi OSK Sfântu GheorgheSepsi OSK Sfâ |
| 30 Jun 22 | r03 | NŠ MuraNŠ Mura | 1 - 1 | VojvodinaVojvodina |
| 30 Jun 22 | r03 | MFK RužomberokMFK Ružombero | 0 - 2 | GKS KatowiceGKS Katowice |
| 30 Jun 22 | r03 | SKU AmstettenSKU Amstetten | 2 - 1 | Wiener ViktoriaWiener Viktor |
| 30 Jun 22 | r03 | Napredak KruševacNapredak Kruš | 1 - 1 | SkalicaSkalica |
| 30 Jun 22 | r03 | Crvena ZvezdaCrvena Zvezda | 0 - 1 | KoperKoper |
| 30 Jun 22 | r03 | SKU AmstettenSKU Amstetten | - | LeobendorfLeobendorf |
| 01 Jul 22 | r03 | AugsburgAugsburg | 5 - 0 | EichstättEichstätt |
| 01 Jul 22 | r03 | BeroeBeroe | 2 - 2 | Litex LovechLitex Lovech |
| 01 Jul 22 | r03 | Neftekhimik NizhnekamskNeftekhimik N | 5 - 1 | Chertanovo MoscowChertanovo Mo |
| 01 Jul 22 | r03 | Widzew LodzWidzew Lodz | 1 - 3 | Sandecja Nowy SaczSandecja Nowy |
| 01 Jul 22 | r03 | Stal MielecStal Mielec | 2 - 0 | Korona KielceKorona Kielce |
| 01 Jul 22 | r03 | Rakow CzestochowaRakow Czestoc | 3 - 0 | Wisla PlockWisla Plock |
| 01 Jul 22 | r03 | Cracovia KrakowCracovia Krak | 1 - 2 | Rapid BucurestiRapid Bucures |
| 01 Jul 22 | r03 | Viktoria PlzenViktoria Plze | 3 - 0 | TáborskoTáborsko |
| 01 Jul 22 | r03 | VoždovacVoždovac | 3 - 0 | MornarMornar |
| 01 Jul 22 | r03 | Novi PazarNovi Pazar | 3 - 0 | Zvijezda 09Zvijezda 09 |
| 01 Jul 22 | r03 | KilmarnockKilmarnock | 1 - 0 | CharltonCharlton |
| 01 Jul 22 | r03 | HibernianHibernian | 4 - 2 | BurtonBurton |
| 01 Jul 22 | r03 | FredericiaFredericia | 1 - 1 | Vejle BoldklubVejle Boldklu |
| 01 Jul 22 | r03 | AberdeenAberdeen | 1 - 1 | St JohnstoneSt Johnstone |
| 01 Jul 22 | r03 | Randers FCRanders FC | - | ViborgViborg |
| 01 Jul 22 | r03 | Wisla PlockWisla Plock | 3 - 0 | Rakow CzestochowaRakow Czestoc |
| 01 Jul 22 | r03 | Silkeborg IFSilkeborg IF | 2 - 0 | St PauliSt Pauli |
| 01 Jul 22 | r03 | Jahn RegensburgJahn Regensbu | 6 - 2 | ZwickauZwickau |
| 01 Jul 22 | r03 | BurnleyBurnley | 1 - 0 | RochdaleRochdale |
| 01 Jul 22 | r03 | Yverdon SportYverdon Sport | 2 - 0 | GrasshoppersGrasshoppers |
| 01 Jul 22 | r03 | Rapid Wien IIRapid Wien II | 4 - 1 | Austria Vienna (Am)Austria Vienn |
| 01 Jul 22 | r03 | BielefeldBielefeld | 3 - 1 | OlympiakosOlympiakos |
| 01 Jul 22 | r03 | AmiensAmiens | 1 - 4 | KV OostendeKV Oostende |
| 01 Jul 22 | r03 | Young BoysYoung Boys | 2 - 2 | Stade Lausanne OuchyStade Lausann |
| 01 Jul 22 | r03 | FC Trenkwalder AdmiraFC Trenkwalde | - | Universitatea CraiovaUniversitatea |
| 01 Jul 22 | r03 | SK Vorwarts SteyrSK Vorwarts S | 0 - 8 | Sparta Prague BSparta Prague |
| 01 Jul 22 | r03 | SochauxSochaux | - | Progrès NiederkornProgrès Niede |
| 01 Jul 22 | r03 | GuingampGuingamp | 3 - 1 | NiortNiort |
| 01 Jul 22 | r03 | Kecskeméti TEKecskeméti TE | 3 - 2 | BékéscsabaBékéscsaba |
| 01 Jul 22 | r03 | FC Trenkwalder AdmiraFC Trenkwalde | 0 - 1 | FC U Craiova 1948FC U Craiova |
| 01 Jul 22 | r03 | Universitatea ClujUniversitatea | 0 - 1 | OsijekOsijek |
| 01 Jul 22 | r03 | Resovia RzeszówResovia Rzesz | 2 - 2 | KosiceKosice |
| 01 Jul 22 | r03 | HamburgHamburg | 4 - 3 | ArisAris |
| 01 Jul 22 | r03 | Floridsdorfer ACFloridsdorfer | 4 - 2 | NŠ MuraNŠ Mura |
| 01 Jul 22 | r03 | NK BravoNK Bravo | 1 - 1 | RijekaRijeka |
| 01 Jul 22 | r03 | DuisburgDuisburg | - | Preußen MünsterPreußen Münst |
| 01 Jul 22 | r03 | FC SchweinfurtFC Schweinfur | 1 - 0 | FSV FrankfurtFSV Frankfurt |
| 01 Jul 22 | r03 | LavalLaval | 1 - 1 | ConcarneauConcarneau |
| 01 Jul 22 | r03 | Hajduk SplitHajduk Split | 0 - 3 | GentGent |
| 01 Jul 22 | r03 | QuevillyQuevilly | - | Paris FCParis FC |
| 01 Jul 22 | r03 | Hamburg IIHamburg II | 3 - 3 | LübeckLübeck |
| 01 Jul 22 | r03 | Slavia SofiaSlavia Sofia | 3 - 0 | Sportist SvogeSportist Svog |
| 01 Jul 22 | r03 | Dinamo ZagrebDinamo Zagreb | 3 - 3 | FC Spartak TrnavaFC Spartak Tr |
| 01 Jul 22 | r03 | Widzew LodzWidzew Lodz | 1 - 0 | Puszcza NiepołomicePuszcza Niepo |
| 01 Jul 22 | r03 | Atlas DelmenhorstAtlas Delmenh | 4 - 3 | VfL OldenburgVfL Oldenburg |
| 01 Jul 22 | r03 | CeljeCelje | 2 - 1 | HNK GoricaHNK Gorica |
| 01 Jul 22 | r03 | TSV Rain am LechTSV Rain am L | 1 - 1 | Augsburg IIAugsburg II |
| 01 Jul 22 | r03 | KalsdorfKalsdorf | 1 - 1 | Grazer AKGrazer AK |
| 01 Jul 22 | r03 | DomzaleDomzale | 1 - 0 | DekaniDekani |
| 01 Jul 22 | r03 | Nizhny NovgorodNizhny Novgor | 1 - 1 | PFC SochiPFC Sochi |
| 01 Jul 22 | r03 | Rot-Weiss EssenRot-Weiss Ess | 2 - 4 | MönchengladbachMönchengladba |
| 01 Jul 22 | r03 | TuS DassendorfTuS Dassendor | 2 - 2 | Holstein Kiel IIHolstein Kiel |
| 01 Jul 22 | r03 | SC CambuurSC Cambuur | 2 - 2 | SV MeppenSV Meppen |
| 01 Jul 22 | r03 | Sturm Graz IISturm Graz II | 2 - 0 | DeutschlandsbergerDeutschlandsb |
| 01 Jul 22 | r03 | SV HornSV Horn | 0 - 0 | StripfingStripfing |
| 01 Jul 22 | r03 | Bradford Park AvenueBradford Park | 0 - 2 | BradfordBradford |
| 01 Jul 22 | r03 | Radnički 1923Radnički 1923 | 1 - 1 | OFK PetrovacOFK Petrovac |
| 01 Jul 22 | r03 | Tiverton TownTiverton Town | 2 - 1 | ExeterExeter |
| 01 Jul 22 | r03 | Dereham TownDereham Town | 0 - 4 | NorwichNorwich |
| 01 Jul 22 | r03 | Undy AthleticUndy Athletic | 0 - 7 | NewportNewport |
| 01 Jul 22 | r03 | Haringey BoroughHaringey Boro | 1 - 2 | Leyton OrientLeyton Orient |
| 01 Jul 22 | r03 | Hitchin TownHitchin Town | 0 - 3 | LutonLuton |
| 01 Jul 22 | r03 | Javor IvanjicaJavor Ivanjic | 3 - 1 | JedinstvoJedinstvo |
| 01 Jul 22 | r03 | Melksham TownMelksham Town | 1 - 6 | Bristol RoversBristol Rover |
| 01 Jul 22 | r03 | BradfordBradford | 0 - 2 | Bradford Park AvenueBradford Park |
| 01 Jul 22 | r03 | Forres MechanicsForres Mechan | 0 - 3 | Elgin CityElgin City |
| 02 Jul 22 | r03 | SunderlandSunderland | - | Blyth SpartansBlyth Spartan |
| 02 Jul 22 | r03 | SkalicaSkalica | - | SFC OpavaSFC Opava |
| 02 Jul 22 | r03 | Wisla KrakowWisla Krakow | 3 - 0 | JastrzębieJastrzębie |
| 02 Jul 22 | r03 | WolvesWolves | 4 - 1 | Forest Green RoversForest Green |
| 02 Jul 22 | r03 | BadenBaden | - | FC AarauFC Aarau |
| 02 Jul 22 | r03 | Chrobry GłogówChrobry Głogó | 1 - 2 | Górnik PolkowiceGórnik Polkow |
| 02 Jul 22 | r03 | Farul ConstantaFarul Constan | 2 - 3 | Chindia TârgovișteChindia Târgo |
| 02 Jul 22 | r03 | NiecieczaNieciecza | 0 - 0 | Banik OstravaBanik Ostrava |
| 02 Jul 22 | r03 | NiceNice | - | FC Lausanne-SportFC Lausanne-S |
| 02 Jul 22 | r03 | CeljeCelje | 2 - 1 | BistricaBistrica |
| 02 Jul 22 | r03 | MFK Zemplín MichalovceMFK Zemplín M | 3 - 0 | HumennéHumenné |
| 02 Jul 22 | r03 | Zaglebie SosnowiecZaglebie Sosn | - | Odra OpoleOdra Opole |
| 02 Jul 22 | r03 | Kisvárda FCKisvárda FC | 1 - 1 | Hajduk SplitHajduk Split |
| 02 Jul 22 | r03 | Mezőkövesdi SEMezőkövesdi S | 1 - 1 | VasasVasas |
| 02 Jul 22 | r03 | PribramPribram | 0 - 3 | VlašimVlašim |
| 02 Jul 22 | r03 | Warta PoznańWarta Poznań | 1 - 0 | Miedz LegnicaMiedz Legnica |
| 02 Jul 22 | r03 | Skra CzęstochowaSkra Częstoch | - | Tychy 71Tychy 71 |
| 02 Jul 22 | r03 | Jagiellonia BialystokJagiellonia B | - | Chojniczanka ChojniceChojniczanka |
| 02 Jul 22 | r03 | FC WinterthurFC Winterthur | 3 - 0 | SchaffhausenSchaffhausen |
| 02 Jul 22 | r03 | Gornik ZabrzeGornik Zabrze | 0 - 3 | Zaglebie LubinZaglebie Lubi |
| 02 Jul 22 | r03 | Podbeskidzie Bielsko-BialPodbeskidzie | 1 - 0 | Ruch ChorzowRuch Chorzow |
| 02 Jul 22 | r03 | SlovackoSlovacko | 2 - 1 | Tatran Liptovský MikulášTatran Liptov |
| 02 Jul 22 | r03 | JastrzębieJastrzębie | - | KarvinaKarvina |
| 02 Jul 22 | r03 | Hradec KrálovéHradec Králov | 3 - 1 | VarnsdorfVarnsdorf |
| 02 Jul 22 | r03 | LiberecLiberec | 8 - 1 | Ústí nad LabemÚstí nad Labe |
| 02 Jul 22 | r03 | JablonecJablonec | - | Bohemians 1905Bohemians 190 |
| 02 Jul 22 | r03 | Dynamo České BudějoviceDynamo České | 3 - 1 | Dukla PrahaDukla Praha |
| 02 Jul 22 | r03 | Mlada BoleslavMlada Bolesla | 3 - 2 | TepliceTeplice |
| 02 Jul 22 | r03 | Sigma OlomoucSigma Olomouc | 0 - 0 | ProstějovProstějov |
| 02 Jul 22 | r03 | GKS KatowiceGKS Katowice | 1 - 2 | Dukla Banská BystricaDukla Banská |
| 02 Jul 22 | r03 | KarvinaKarvina | 0 - 2 | ZlínZlín |
| 02 Jul 22 | r03 | MTK HungariaMTK Hungaria | 2 - 6 | Újpest FCÚjpest FC |
| 02 Jul 22 | r03 | JablonecJablonec | 1 - 2 | Viktoria ŽižkovViktoria Žižk |
| 02 Jul 22 | r03 | SFC OpavaSFC Opava | 2 - 2 | Považská BystricaPovažská Byst |
| 02 Jul 22 | r03 | TřinecTřinec | 5 - 0 | MSK Zilina BMSK Zilina B |
| 02 Jul 22 | r03 | Piast GliwicePiast Gliwice | 2 - 0 | Stal RzeszówStal Rzeszów |
| 02 Jul 22 | r03 | SunderlandSunderland | - | Gateshead FCGateshead FC |
| 02 Jul 22 | r03 | SønderjyskeSønderjyske | 1 - 1 | EsbjergEsbjerg |
| 02 Jul 22 | r03 | Jong PSVJong PSV | 1 - 2 | Jong SpartaJong Sparta |
| 02 Jul 22 | r03 | Odense BKOdense BK | 1 - 3 | AC HorsensAC Horsens |
| 02 Jul 22 | r03 | LyngbyLyngby | 2 - 0 | NykøbingNykøbing |
| 02 Jul 22 | r03 | Jong AZJong AZ | 1 - 3 | Almere City FCAlmere City F |
| 02 Jul 22 | r03 | Cove RangersCove Rangers | 8 - 1 | Gala Fairydean RoversGala Fairydea |
| 02 Jul 22 | r03 | Hallescher FCHallescher FC | 1 - 3 | Hertha IIHertha II |
| 02 Jul 22 | r03 | Fremad AmagerFremad Amager | 3 - 0 | Hvidovre IFHvidovre IF |
| 02 Jul 22 | r03 | TSG BalingenTSG Balingen | - | Rielasingen-ArlenRielasingen-A |
| 02 Jul 22 | r03 | StandardStandard | 1 - 2 | MolenbeekMolenbeek |
| 02 Jul 22 | r03 | FC WilFC Wil | 1 - 3 | DornbirnDornbirn |
| 02 Jul 22 | r03 | Kecskeméti TEKecskeméti TE | - | Szentlőrinc SESzentlőrinc S |
| 02 Jul 22 | r03 | Wisla KrakowWisla Krakow | - | Resovia RzeszówResovia Rzesz |
| 02 Jul 22 | r03 | Chayka PeschanokopskoyeChayka Pescha | - | FC Biolog-NovokubanskFC Biolog-Nov |
| 02 Jul 22 | r03 | Wehen WiesbadenWehen Wiesbad | 4 - 1 | Nurnberg IINurnberg II |
| 02 Jul 22 | r03 | Fortuna SittardFortuna Sitta | 2 - 3 | Viktoria KölnViktoria Köln |
| 02 Jul 22 | r03 | FC DordrechtFC Dordrecht | 4 - 2 | KortrijkKortrijk |
| 02 Jul 22 | r03 | BocholtBocholt | 1 - 3 | BochumBochum |
| 02 Jul 22 | r03 | Gala Fairydean RoversGala Fairydea | 8 - 1 | Cove RangersCove Rangers |
| 02 Jul 22 | r03 | Hertha IIHertha II | 1 - 3 | Hallescher FCHallescher FC |
| 02 Jul 22 | r03 | Almere City FCAlmere City F | - | AZ AlkmaarAZ Alkmaar |
| 02 Jul 22 | r03 | Lippstadt 08Lippstadt 08 | - | OldenburgOldenburg |
| 02 Jul 22 | r03 | TuS KoblenzTuS Koblenz | 0 - 1 | Fortuna DüsseldorfFortuna Düsse |
| 02 Jul 22 | r03 | LeamingtonLeamington | 1 - 3 | CoventryCoventry |
| 02 Jul 22 | r03 | OsnabrueckOsnabrueck | - | WolfsburgWolfsburg |
| 02 Jul 22 | r03 | ReadingReading | 2 - 0 | ColchesterColchester |
| 02 Jul 22 | r03 | Berliner AK 07Berliner AK 0 | 0 - 3 | Schwarz-Weiß RehdenSchwarz-Weiß |
| 02 Jul 22 | r03 | Roda JCRoda JC | - | AnderlechtAnderlecht |
| 02 Jul 22 | r03 | KMSK DeinzeKMSK Deinze | 0 - 1 | St. GilloiseSt. Gilloise |
| 02 Jul 22 | r03 | WatfordWatford | 1 - 3 | Cambridge UnitedCambridge Uni |
| 02 Jul 22 | r03 | Union FürstenwaldeUnion Fürsten | 1 - 7 | VSG AltglienickeVSG Altglieni |
| 02 Jul 22 | r03 | Mainz IIMainz II | 1 - 3 | Viktoria AschaffenburgViktoria Asch |
| 02 Jul 22 | r03 | Jong UtrechtJong Utrecht | 4 - 0 | Mgladbach IIMgladbach II |
| 02 Jul 22 | r03 | Crystal PalaceCrystal Palac | 1 - 1 | AccringtonAccrington |
| 02 Jul 22 | r03 | Fleetwood TownFleetwood Tow | 2 - 2 | TranmereTranmere |
| 02 Jul 22 | r03 | Bedford TownBedford Town | 0 - 2 | AFC WimbledonAFC Wimbledon |
| 02 Jul 22 | r03 | Jahn RegensburgJahn Regensbu | 0 - 0 | SpVgg BayreuthSpVgg Bayreut |
| 02 Jul 22 | r03 | Wormatia WormsWormatia Worm | 0 - 4 | MainzMainz |
| 02 Jul 22 | r03 | FK PohronieFK Pohronie | 1 - 2 | ŠamorínŠamorín |
| 02 Jul 22 | r03 | LinfieldLinfield | 1 - 2 | St MirrenSt Mirren |
| 02 Jul 22 | r03 | RKC WaalwijkRKC Waalwijk | 5 - 3 | TOP OssTOP Oss |
| 02 Jul 22 | r03 | BrøndbyBrøndby | - | AGF AarhusAGF Aarhus |
| 02 Jul 22 | r03 | UDI 19UDI 19 | 1 - 3 | Willem IIWillem II |
| 02 Jul 22 | r03 | FreiburgFreiburg | 0 - 0 | ElversbergElversberg |
| 02 Jul 22 | r03 | ChorleyChorley | 1 - 3 | BoltonBolton |
| 02 Jul 22 | r03 | SPVGG Greuther FürthSPVGG Greuthe | 1 - 0 | PardubicePardubice |
| 02 Jul 22 | r03 | Gretna 2008Gretna 2008 | 2 - 3 | DumbartonDumbarton |
| 02 Jul 22 | r03 | East FifeEast Fife | 3 - 0 | CowdenbeathCowdenbeath |
| 02 Jul 22 | r03 | AlloaAlloa | 2 - 0 | ForfarForfar |
| 02 Jul 22 | r03 | Sturm GrazSturm Graz | 0 - 0 | FC LieferingFC Liefering |
| 02 Jul 22 | r03 | Peterhead FCPeterhead FC | - | Dundee UnitedDundee United |
| 02 Jul 22 | r03 | MontroseMontrose | 1 - 1 | ArbroathArbroath |
| 02 Jul 22 | r03 | Kickers OffenbachKickers Offen | 3 - 0 | TSV AubstadtTSV Aubstadt |
| 02 Jul 22 | r03 | Eintracht TrierEintracht Tri | 3 - 0 | Schott MainzSchott Mainz |
| 02 Jul 22 | r03 | Peterhead FCPeterhead FC | 0 - 4 | Dundee FCDundee FC |
| 02 Jul 22 | r03 | EupenEupen | 4 - 1 | AachenAachen |
| 02 Jul 22 | r03 | SV SalzburgSV Salzburg | 3 - 1 | OlympiakosOlympiakos |
| 02 Jul 22 | r03 | Club BruggeClub Brugge | - | Beerschot VABeerschot VA |
| 02 Jul 22 | r03 | KaiserslauternKaiserslauter | 3 - 0 | UnterhachingUnterhaching |
| 02 Jul 22 | r03 | FC GroningenFC Groningen | 2 - 1 | PAOKPAOK |
| 02 Jul 22 | r03 | Blau-Weiß LohneBlau-Weiß Loh | 0 - 7 | Schalke 04Schalke 04 |
| 02 Jul 22 | r03 | PúchovPúchov | 0 - 3 | TrencinTrencin |
| 02 Jul 22 | r03 | Evesham UnitedEvesham Unite | 0 - 4 | CheltenhamCheltenham |
| 02 Jul 22 | r03 | Austria LustenauAustria Luste | 0 - 4 | St. GallenSt. Gallen |
| 02 Jul 22 | r03 | Nantwich TownNantwich Town | 0 - 3 | CreweCrewe |
| 02 Jul 22 | r03 | SouthportSouthport | 0 - 2 | BlackpoolBlackpool |
| 02 Jul 22 | r03 | Folkestone InvictaFolkestone In | 0 - 2 | GillinghamGillingham |
| 02 Jul 22 | r03 | Nuneaton TownNuneaton Town | 0 - 4 | StockportStockport |
| 02 Jul 22 | r03 | Havant & WaterloovilleHavant & Wate | 0 - 3 | PortsmouthPortsmouth |
| 02 Jul 22 | r03 | Plymouth ParkwayPlymouth Park | 2 - 2 | PlymouthPlymouth |
| 02 Jul 22 | r03 | PrestonPreston | 0 - 3 | Bamber BridgeBamber Bridge |
| 02 Jul 22 | r03 | GainsboroughGainsborough | 0 - 4 | LincolnLincoln |
| 02 Jul 22 | r03 | LucerneLucerne | 4 - 1 | VaduzVaduz |
| 02 Jul 22 | r03 | SV BabelsbergSV Babelsberg | 0 - 1 | HerthaHertha |
| 02 Jul 22 | r03 | Kelty HeartsKelty Hearts | 1 - 1 | Raith RvsRaith Rvs |
| 02 Jul 22 | r03 | Melksham TownMelksham Town | 2 - 3 | SwindonSwindon |
| 02 Jul 22 | r03 | Atherton CollieriesAtherton Coll | 2 - 1 | Annan AthleticAnnan Athleti |
| 02 Jul 22 | r03 | Sigma OlomoucSigma Olomouc | 1 - 3 | MSK ZilinaMSK Zilina |
| 02 Jul 22 | r03 | HamiltonHamilton | 1 - 3 | Queen of SouthQueen of Sout |
| 02 Jul 22 | r03 | ChrudimChrudim | 2 - 1 | Vysočina JihlavaVysočina Jihl |
| 02 Jul 22 | r03 | Grazer AKGrazer AK | 1 - 4 | DomzaleDomzale |
| 02 Jul 22 | r03 | Brora RangersBrora Rangers | 0 - 1 | Inverness CInverness C |
| 02 Jul 22 | r03 | OsnabrueckOsnabrueck | - | HannoverHannover |
| 02 Jul 22 | r03 | LivingstonLivingston | 0 - 3 | MortonMorton |
| 02 Jul 22 | r03 | Alfreton TownAlfreton Town | 0 - 0 | Sheffield WedsSheffield Wed |
| 02 Jul 22 | r03 | LensLens | 0 - 0 | Paris FCParis FC |
| 02 Jul 22 | r03 | AntwerpAntwerp | - | MechelenMechelen |
| 02 Jul 22 | r03 | Wolfsberger ACWolfsberger A | 0 - 1 | Holstein KielHolstein Kiel |
| 02 Jul 22 | r03 | AZ AlkmaarAZ Alkmaar | 3 - 1 | PEC ZwollePEC Zwolle |
| 02 Jul 22 | r03 | Spartak MoscowSpartak Mosco | 3 - 0 | FC Yenisey KrasnoyarskFC Yenisey Kr |
| 02 Jul 22 | r03 | FC Krasnodar-2FC Krasnodar- | 2 - 2 | Chayka PeschanokopskoyeChayka Pescha |
| 02 Jul 22 | r03 | Eastbourne BoroughEastbourne Bo | 0 - 1 | CrawleyCrawley |
| 02 Jul 22 | r03 | Sutton Common RoversSutton Common | 1 - 5 | Tonbridge AngelsTonbridge Ang |
| 02 Jul 22 | r03 | SAK KlagenfurtSAK Klagenfur | 0 - 0 | Hansa RostockHansa Rostock |
| 02 Jul 22 | r03 | ThunThun | 2 - 1 | Stade Lausanne OuchyStade Lausann |
| 02 Jul 22 | r03 | SKN St. PoltenSKN St. Polte | 4 - 0 | TSV HartbergTSV Hartberg |
| 02 Jul 22 | r03 | MagdeburgMagdeburg | 1 - 4 | Union BerlinUnion Berlin |
| 02 Jul 22 | r03 | Radnički NišRadnički Niš | 1 - 3 | Slask WroclawSlask Wroclaw |
| 02 Jul 22 | r03 | Rapid ViennaRapid Vienna | 2 - 3 | AEK LarnacaAEK Larnaca |
| 02 Jul 22 | r03 | Rot-Weiß KoblenzRot-Weiß Kobl | 4 - 2 | Fortuna Düsseldorf IIFortuna Düsse |
| 02 Jul 22 | r03 | Cherno MoreCherno More | 2 - 1 | DobrudzhaDobrudzha |
| 02 Jul 22 | r03 | Lokomotiv SofiaLokomotiv Sof | 2 - 3 | Septemvri SofiaSeptemvri Sof |
| 02 Jul 22 | r03 | Gornik LecznaGornik Leczna | 2 - 1 | FC VoluntariFC Voluntari |
| 02 Jul 22 | r03 | Farul ConstantaFarul Constan | 2 - 2 | CsikszeredaCsikszereda |
| 02 Jul 22 | r03 | Hebar PazardzhikHebar Pazardz | 1 - 1 | Vitosha BistritsaVitosha Bistr |
| 02 Jul 22 | r03 | FC Spartak TrnavaFC Spartak Tr | - | Zbrojovka BrnoZbrojovka Brn |
| 02 Jul 22 | r03 | LASKLASK | 2 - 0 | Rapid BucurestiRapid Bucures |
| 02 Jul 22 | r03 | AuxerreAuxerre | 1 - 2 | GrenobleGrenoble |
| 02 Jul 22 | r03 | Austria ViennaAustria Vienn | 0 - 3 | First ViennaFirst Vienna |
| 02 Jul 22 | r03 | Zbrojovka BrnoZbrojovka Brn | 2 - 2 | Slovan BratislavaSlovan Bratis |
| 02 Jul 22 | r03 | Maritsa PlovdivMaritsa Plovd | 0 - 3 | ŠibenikŠibenik |
| 02 Jul 22 | r03 | VV HoogezandVV Hoogezand | 0 - 11 | FC EmmenFC Emmen |
| 02 Jul 22 | r03 | WesterloWesterlo | 2 - 1 | Maccabi Tel AvivMaccabi Tel A |
| 02 Jul 22 | r03 | Astoria WalldorfAstoria Walld | 0 - 4 | HoffenheimHoffenheim |
| 02 Jul 22 | r03 | Sturm GrazSturm Graz | 1 - 1 | FC BW LinzFC BW Linz |
| 02 Jul 22 | r03 | Oud-Heverlee LeuvenOud-Heverlee | 3 - 1 | CharleroiCharleroi |
| 02 Jul 22 | r03 | Zimbru ChisinauZimbru Chisin | 1 - 6 | Steaua BucurestiSteaua Bucure |
| 02 Jul 22 | r03 | FK RostovFK Rostov | 2 - 0 | PFC Kuban KrasnodarPFC Kuban Kra |
| 02 Jul 22 | r03 | FK Železiarne PodbrezováFK Železiarne | 4 - 0 | ViOn Zlaté MoravceViOn Zlaté Mo |
| 02 Jul 22 | r03 | Pirin BlagoevgradPirin Blagoev | 1 - 0 | BelasitsaBelasitsa |
| 02 Jul 22 | r03 | ToulouseToulouse | 2 - 0 | NimesNimes |
| 02 Jul 22 | r03 | FC UtrechtFC Utrecht | 2 - 4 | Queens ParkQueens Park |
| 02 Jul 22 | r03 | Spartak SuboticaSpartak Subot | 3 - 0 | Radnički Sremska MitrovicRadnički Srem |
| 02 Jul 22 | r03 | FC Krasnodar-2FC Krasnodar- | 2 - 0 | FC Biolog-NovokubanskFC Biolog-Nov |
| 02 Jul 22 | r03 | CSKA 1948CSKA 1948 | 0 - 0 | Apoel NicosiaApoel Nicosia |
| 02 Jul 22 | r03 | KolubaraKolubara | 1 - 2 | ZeljeznicarZeljeznicar |
| 02 Jul 22 | r03 | Bohemians 1905Bohemians 190 | 2 - 1 | Cracovia KrakowCracovia Krak |
| 02 Jul 22 | r03 | CSKA SofiaCSKA Sofia | - | Apoel NicosiaApoel Nicosia |
| 02 Jul 22 | r03 | GoricaGorica | 1 - 1 | PrimorjePrimorje |
| 02 Jul 22 | r03 | Slaven Belupo KoprivnicaSlaven Belupo | 1 - 2 | Zalaegerszegi TEZalaegerszegi |
| 02 Jul 22 | r03 | AueAue | 4 - 0 | Lokomotive LeipzigLokomotive Le |
| 02 Jul 22 | r03 | FK PirmasensFK Pirmasens | 1 - 1 | FC SaarbrückenFC Saarbrücke |
| 02 Jul 22 | r03 | ServetteServette | 5 - 1 | Neuchâtel XamaxNeuchâtel Xam |
| 02 Jul 22 | r03 | FC SionFC Sion | 0 - 1 | Dynamo KievDynamo Kiev |
| 02 Jul 22 | r03 | Go Ahead EaglesGo Ahead Eagl | 2 - 0 | NK LokomotivaNK Lokomotiva |
| 02 Jul 22 | r03 | Botev PlovdivBotev Plovdiv | 0 - 0 | Yantra GabrovoYantra Gabrov |
| 02 Jul 22 | r03 | FC 03 DifferdangeFC 03 Differd | 0 - 0 | RFC SeraingRFC Seraing |
| 02 Jul 22 | r03 | VirtonVirton | 1 - 5 | FolaFola |
| 02 Jul 22 | r03 | Oxford CityOxford City | 2 - 5 | Oxford UtdOxford Utd |
| 03 Jul 22 | r03 | FC Krasnodar-2FC Krasnodar- | - | FC Forte TaganrogFC Forte Taga |
| 03 Jul 22 | r03 | Dynamo DresdenDynamo Dresde | 0 - 0 | St.TruidenSt.Truiden |
| 03 Jul 22 | r03 | Radomiak RadomRadomiak Rado | 3 - 2 | Arka GdyniaArka Gdynia |
| 03 Jul 22 | r03 | Universitatea CraiovaUniversitatea | 1 - 0 | FC HeidenheimFC Heidenheim |
| 03 Jul 22 | r03 | Bischofswerdaer FVBischofswerda | 1 - 2 | Chemie LeipzigChemie Leipzi |
| 03 Jul 22 | r03 | FC TwenteFC Twente | 1 - 0 | FC NordsjællandFC Nordsjælla |
| 03 Jul 22 | r03 | WSG Swarovski TirolWSG Swarovski | 2 - 0 | NurnbergNurnberg |
| 03 Jul 22 | r03 | KarlsruheKarlsruhe | 1 - 2 | Werder BremenWerder Bremen |
| 03 Jul 22 | r03 | Lok. MoscowLok. Moscow | - | Fakel VoronezhFakel Voronez |
| 03 Jul 22 | r03 | Werder BremenWerder Bremen | 2 - 1 | KarlsruheKarlsruhe |
| 03 Jul 22 | r03 | Gosport BoroughGosport Borou | 1 - 0 | PortsmouthPortsmouth |
| 03 Jul 22 | r03 | TubizeTubize | 0 - 4 | WaregemWaregem |
| 03 Jul 22 | r03 | NK AluminijNK Aluminij | 1 - 0 | Universitatea ClujUniversitatea |
| 03 Jul 22 | r03 | Baltika KaliningradBaltika Kalin | 0 - 1 | Alania VladikavkazAlania Vladik |
| 03 Jul 22 | r03 | Universitatea ClujUniversitatea | 1 - 0 | NK AluminijNK Aluminij |
| 03 Jul 22 | r03 | RadomljeRadomlje | 1 - 2 | Slask WroclawSlask Wroclaw |
| 03 Jul 22 | r03 | FC KrasnodarFC Krasnodar | 2 - 1 | FC Forte TaganrogFC Forte Taga |
| 03 Jul 22 | r03 | Zenit St PetersburgZenit St Pete | 2 - 1 | Crvena ZvezdaCrvena Zvezda |
| 04 Jul 22 | r03 | FC Anzhi MakhachkalaFC Anzhi Makh | 3 - 0 | PFC Dynamo StavropolPFC Dynamo St |
| 04 Jul 22 | r03 | Randers FCRanders FC | 5 - 1 | Vendsyssel FFVendsyssel FF |
| 04 Jul 22 | r03 | ArisAris | 1 - 0 | GentGent |
| 04 Jul 22 | r03 | SKA-KhabarovskSKA-Khabarovs | 1 - 3 | Torpedo MoscowTorpedo Mosco |
| 04 Jul 22 | r03 | Khimki FKKhimki FK | 0 - 0 | Veles MoscowVeles Moscow |
| 04 Jul 22 | r03 | Kisvárda FCKisvárda FC | - | Universitatea CraiovaUniversitatea |
| 04 Jul 22 | r03 | Kisvárda FCKisvárda FC | 2 - 1 | FC U Craiova 1948FC U Craiova |
| 04 Jul 22 | r03 | CSKA MoscowCSKA Moscow | 0 - 2 | Nizhny NovgorodNizhny Novgor |
| 04 Jul 22 | r03 | Leyton OrientLeyton Orient | 1 - 2 | West BromWest Brom |
| 05 Jul 22 | r03 | Krylya Sovetov SamaraKrylya Soveto | 1 - 0 | Terek GroznyTerek Grozny |
| 05 Jul 22 | r03 | Ural S.RUral S.R | 1 - 4 | FC UfaFC Ufa |
| 05 Jul 22 | r03 | Volgar AstrakhanVolgar Astrak | 1 - 2 | FC Yenisey KrasnoyarskFC Yenisey Kr |
| 05 Jul 22 | r03 | BrøndbyBrøndby | 1 - 0 | LyngbyLyngby |
| 05 Jul 22 | r03 | BoltonBolton | 2 - 2 | StockportStockport |
| 05 Jul 22 | r03 | Tekstilshchik IvanovoTekstilshchik | 1 - 1 | FC Yenisey KrasnoyarskFC Yenisey Kr |
| 05 Jul 22 | r03 | Dinamo MoscowDinamo Moscow | 2 - 0 | FK Rubin KazanFK Rubin Kaza |
| 05 Jul 22 | r03 | AnnecyAnnecy | 1 - 0 | ServetteServette |
| 05 Jul 22 | r03 | SlovackoSlovacko | 2 - 0 | TřinecTřinec |
| 05 Jul 22 | r03 | SK Vorwarts SteyrSK Vorwarts S | 1 - 2 | ZwickauZwickau |
| 05 Jul 22 | r03 | FC VoluntariFC Voluntari | 1 - 4 | Hapoel Beer ShevaHapoel Beer S |
| 05 Jul 22 | r03 | ServetteServette | 0 - 1 | AnnecyAnnecy |
| 05 Jul 22 | r03 | Kisvárda FCKisvárda FC | 2 - 2 | AEK LarnacaAEK Larnaca |
| 05 Jul 22 | r03 | Warta PoznańWarta Poznań | 1 - 3 | AaBAaB |
| 05 Jul 22 | r03 | Levski SofiaLevski Sofia | 5 - 0 | Etar Veliko TarnovoEtar Veliko T |
| 05 Jul 22 | r03 | Rapid BucurestiRapid Bucures | 1 - 7 | Slavia PragueSlavia Prague |
| 05 Jul 22 | r03 | Viktoria PlzenViktoria Plze | 0 - 0 | FC BotoșaniFC Botoșani |
| 05 Jul 22 | r03 | SandhausenSandhausen | 3 - 1 | Astoria WalldorfAstoria Walld |
| 05 Jul 22 | r03 | Triglav KranjTriglav Kranj | 1 - 5 | RijekaRijeka |
| 05 Jul 22 | r03 | Donaufeld WienDonaufeld Wie | 0 - 2 | Floridsdorfer ACFloridsdorfer |
| 05 Jul 22 | r03 | Viktoria AschaffenburgViktoria Asch | 0 - 1 | Ein FrankfurtEin Frankfurt |
| 05 Jul 22 | r03 | CeljeCelje | 2 - 0 | FK SarajevoFK Sarajevo |
| 05 Jul 22 | r03 | Young BoysYoung Boys | 0 - 0 | Dynamo KievDynamo Kiev |
| 05 Jul 22 | r03 | SC HeerenveenSC Heerenveen | 4 - 1 | TOP OssTOP Oss |
| 05 Jul 22 | r03 | TSV Steinbach HaigerTSV Steinbach | 4 - 0 | Kaan-MarienbornKaan-Marienbo |
| 05 Jul 22 | r03 | CSKA SofiaCSKA Sofia | 2 - 0 | Sportist SvogeSportist Svog |
| 05 Jul 22 | r03 | Sturm Graz IISturm Graz II | 1 - 2 | WeizWeiz |
| 05 Jul 22 | r03 | HamiltonHamilton | 4 - 0 | Tranent Juniors F.C.Tranent Junio |
| 05 Jul 22 | r03 | Hitchin TownHitchin Town | 0 - 3 | StevenageStevenage |
| 05 Jul 22 | r03 | St MirrenSt Mirren | - | HartlepoolHartlepool |
| 05 Jul 22 | r03 | SC TelstarSC Telstar | 2 - 0 | FC LisseFC Lisse |
| 05 Jul 22 | r03 | St MirrenSt Mirren | 1 - 3 | NorthamptonNorthampton |
| 05 Jul 22 | r03 | Tranent Juniors F.C.Tranent Junio | 0 - 4 | HamiltonHamilton |
| 05 Jul 22 | r03 | East FifeEast Fife | 0 - 7 | HeartsHearts |
| 05 Jul 22 | r03 | AlloaAlloa | 0 - 0 | Queens ParkQueens Park |
| 05 Jul 22 | r03 | AshtonAshton | 0 - 1 | BarrowBarrow |
| 05 Jul 22 | r03 | Bamber BridgeBamber Bridge | 1 - 5 | WiganWigan |
| 05 Jul 22 | r03 | AFC Rushden & DiamondsAFC Rushden & | 0 - 4 | Milton Keynes DonsMilton Keynes |
| 05 Jul 22 | r03 | DunfermlineDunfermline | 0 - 1 | KilmarnockKilmarnock |
| 05 Jul 22 | r03 | Stratford TownStratford Tow | 1 - 2 | BurtonBurton |
| 05 Jul 22 | r03 | StalybridgeStalybridge | 1 - 2 | MorecambeMorecambe |
| 05 Jul 22 | r03 | Dorking WanderersDorking Wande | 1 - 2 | Sutton UnitedSutton United |
| 05 Jul 22 | r03 | Weston-super-Mare FCWeston-super- | 0 - 5 | ExeterExeter |
| 05 Jul 22 | r03 | Bedford TownBedford Town | 0 - 4 | BarnetBarnet |
| 05 Jul 22 | r03 | WorkingtonWorkington | 0 - 3 | DumbartonDumbarton |
| 05 Jul 22 | r03 | RothesRothes | - | Elgin CityElgin City |
| 05 Jul 22 | r03 | Basford Utd.Basford Utd. | 1 - 5 | Notts CountyNotts County |
| 05 Jul 22 | r03 | MontroseMontrose | - | Dundee UnitedDundee United |
| 05 Jul 22 | r03 | HendonHendon | 0 - 4 | WealdstoneWealdstone |
| 05 Jul 22 | r03 | LivingstonLivingston | 6 - 0 | Linlithgow Rose F.C.Linlithgow Ro |
| 05 Jul 22 | r03 | MontroseMontrose | 1 - 1 | Dundee FCDundee FC |
| 05 Jul 22 | r03 | MacclesfieldMacclesfield | 2 - 1 | CreweCrewe |
| 05 Jul 22 | r03 | CliftonvilleCliftonville | - | Ballyclare ComradesBallyclare Co |
| 06 Jul 22 | r03 | PetrolulPetrolul | 2 - 1 | Farul ConstantaFarul Constan |
| 06 Jul 22 | r03 | GuingampGuingamp | 3 - 0 | US AvranchesUS Avranches |
| 06 Jul 22 | r03 | FC UtrechtFC Utrecht | 1 - 2 | GenkGenk |
| 06 Jul 22 | r03 | Sparta PragueSparta Prague | 2 - 0 | RijekaRijeka |
| 06 Jul 22 | r03 | DiosgyorDiosgyor | - | Dukla Banská BystricaDukla Banská |
| 06 Jul 22 | r03 | Wisla KrakowWisla Krakow | 1 - 0 | Hapoel Beer ShevaHapoel Beer S |
| 06 Jul 22 | r03 | Slaven Belupo KoprivnicaSlaven Belupo | 4 - 2 | Aris LimassolAris Limassol |
| 06 Jul 22 | r03 | Gornik ZabrzeGornik Zabrze | 2 - 1 | VorsklaVorskla |
| 06 Jul 22 | r03 | VasasVasas | 4 - 1 | KomárnoKomárno |
| 06 Jul 22 | r03 | Sigma OlomoucSigma Olomouc | 3 - 0 | Vysočina JihlavaVysočina Jihl |
| 06 Jul 22 | r03 | LiberecLiberec | 1 - 1 | Dukla PrahaDukla Praha |
| 06 Jul 22 | r03 | Mlada BoleslavMlada Bolesla | 4 - 0 | PardubicePardubice |
| 06 Jul 22 | r03 | Zalaegerszegi TEZalaegerszegi | 2 - 3 | Slask WroclawSlask Wroclaw |
| 06 Jul 22 | r03 | VarnsdorfVarnsdorf | 1 - 1 | Viktoria ŽižkovViktoria Žižk |
| 06 Jul 22 | r03 | SFC OpavaSFC Opava | 3 - 0 | JastrzębieJastrzębie |
| 06 Jul 22 | r03 | Jong AZJong AZ | 4 - 0 | Jong SpartaJong Sparta |
| 06 Jul 22 | r03 | Bristol CityBristol City | 2 - 0 | CheltenhamCheltenham |
| 06 Jul 22 | r03 | MechelenMechelen | - | Go Ahead EaglesGo Ahead Eagl |
| 06 Jul 22 | r03 | Volgar AstrakhanVolgar Astrak | 1 - 0 | Arsenal TulaArsenal Tula |
| 06 Jul 22 | r03 | ZlínZlín | 3 - 0 | VyškovVyškov |
| 06 Jul 22 | r03 | LíšeňLíšeň | 0 - 2 | Banik OstravaBanik Ostrava |
| 06 Jul 22 | r03 | Steaua BucurestiSteaua Bucure | 1 - 0 | CS MioveniCS Mioveni |
| 06 Jul 22 | r03 | GoricaGorica | 1 - 1 | Slask WroclawSlask Wroclaw |
| 06 Jul 22 | r03 | SPVGG Greuther FürthSPVGG Greuthe | 3 - 1 | IngolstadtIngolstadt |
| 06 Jul 22 | r03 | Optik RathenowOptik Ratheno | 1 - 5 | SV BabelsbergSV Babelsberg |
| 06 Jul 22 | r03 | KazincbarcikaKazincbarcika | 1 - 1 | Mezőkövesdi SEMezőkövesdi S |
| 06 Jul 22 | r03 | PFC Kuban KrasnodarPFC Kuban Kra | 2 - 0 | FC SKA Rostov-on-DonFC SKA Rostov |
| 06 Jul 22 | r03 | SKN St. PoltenSKN St. Polte | 0 - 4 | Puskás Akadémia FCPuskás Akadém |
| 06 Jul 22 | r03 | Schalke 04Schalke 04 | 1 - 0 | SC VerlSC Verl |
| 06 Jul 22 | r03 | Warta PoznańWarta Poznań | 4 - 2 | Chojniczanka ChojniceChojniczanka |
| 06 Jul 22 | r03 | Paksi FCPaksi FC | 2 - 2 | Szeged-CsanádSzeged-Csanád |
| 06 Jul 22 | r03 | FK PohronieFK Pohronie | 3 - 4 | TrencinTrencin |
| 06 Jul 22 | r03 | Fortuna SittardFortuna Sitta | 1 - 1 | BochumBochum |
| 06 Jul 22 | r03 | BraunschweigBraunschweig | 1 - 0 | Union BerlinUnion Berlin |
| 06 Jul 22 | r03 | Oud-Heverlee LeuvenOud-Heverlee | 2 - 1 | Beerschot VABeerschot VA |
| 06 Jul 22 | r03 | RadomljeRadomlje | - | Triglav KranjTriglav Kranj |
| 06 Jul 22 | r03 | MonacoMonaco | 2 - 2 | Austria ViennaAustria Vienn |
| 06 Jul 22 | r03 | Universitatea CraiovaUniversitatea | 1 - 1 | Al-Duhail SCAl-Duhail SC |
| 06 Jul 22 | r03 | Stade NyonnaisStade Nyonnai | - | FC Lausanne-SportFC Lausanne-S |
| 06 Jul 22 | r03 | NaftaNafta | 0 - 4 | Kispest HonvedKispest Honve |
| 06 Jul 22 | r03 | Munich 1860Munich 1860 | 1 - 1 | LASKLASK |
| 06 Jul 22 | r03 | Grazer AKGrazer AK | 2 - 1 | Wolfsberger ACWolfsberger A |
| 06 Jul 22 | r03 | Wacker BurghausenWacker Burgha | 1 - 2 | Dortmund IIDortmund II |
| 06 Jul 22 | r03 | St. GilloiseSt. Gilloise | 2 - 2 | Racing FC Union LuxembourRacing FC Uni |
| 06 Jul 22 | r03 | CelticCeltic | 7 - 0 | Wiener ViktoriaWiener Viktor |
| 06 Jul 22 | r03 | AZ AlkmaarAZ Alkmaar | 2 - 2 | PAOKPAOK |
| 06 Jul 22 | r03 | FC LieferingFC Liefering | 2 - 0 | GrödigGrödig |
| 06 Jul 22 | r03 | Hamburg IIHamburg II | 2 - 1 | Eintracht Norderstedt 03Eintracht Nor |
| 06 Jul 22 | r03 | VV KatwijkVV Katwijk | 2 - 1 | PEC ZwollePEC Zwolle |
| 06 Jul 22 | r03 | FC Lausanne-SportFC Lausanne-S | 2 - 1 | BulleBulle |
| 06 Jul 22 | r03 | ShrewsburyShrewsbury | - | Qatar SCQatar SC |
| 06 Jul 22 | r03 | Bath CityBath City | 1 - 3 | ColchesterColchester |
| 06 Jul 22 | r03 | Dinamo ZagrebDinamo Zagreb | 5 - 1 | Arsenal TivatArsenal Tivat |
| 06 Jul 22 | r03 | Kidsgrove AthleticKidsgrove Ath | 0 - 6 | CreweCrewe |
| 06 Jul 22 | r03 | Kendal TownKendal Town | 0 - 9 | CarlisleCarlisle |
| 06 Jul 22 | r03 | Brora RangersBrora Rangers | 1 - 4 | Ross CountyRoss County |
| 06 Jul 22 | r03 | Brechin CityBrechin City | 1 - 7 | AberdeenAberdeen |
| 06 Jul 22 | r03 | Elgin CityElgin City | 0 - 4 | Rangers BRangers B |
| 07 Jul 22 | r03 | InhuletsInhulets | 4 - 1 | KreminKremin |
| 07 Jul 22 | r03 | Makedonija GjPMakedonija Gj | 0 - 2 | Apoel NicosiaApoel Nicosia |
| 07 Jul 22 | r03 | Schalke 04 IISchalke 04 II | 7 - 1 | Sportfreunde LotteSportfreunde |
| 07 Jul 22 | r03 | FC HermannstadtFC Hermannsta | 0 - 2 | Unirea DejUnirea Dej |
| 07 Jul 22 | r03 | FC VoluntariFC Voluntari | 1 - 1 | KarmiotissaKarmiotissa |
| 07 Jul 22 | r03 | FK RostovFK Rostov | 3 - 2 | FC Forte TaganrogFC Forte Taga |
| 07 Jul 22 | r03 | Aris LimassolAris Limassol | 1 - 0 | ArisAris |
| 07 Jul 22 | r03 | PFC SochiPFC Sochi | 1 - 2 | CSKA MoscowCSKA Moscow |
| 07 Jul 22 | r03 | RotherhamRotherham | 2 - 0 | Fleetwood TownFleetwood Tow |
| 07 Jul 22 | r03 | LeedsLeeds | 4 - 0 | BlackpoolBlackpool |
| 07 Jul 22 | r03 | Kidsgrove AthleticKidsgrove Ath | 3 - 0 | Port ValePort Vale |
| 08 Jul 22 | r03 | Sandecja Nowy SaczSandecja Nowy | 0 - 0 | NiecieczaNieciecza |
| 08 Jul 22 | r03 | Korona KielceKorona Kielce | 0 - 2 | Wisla PlockWisla Plock |
| 08 Jul 22 | r03 | Stal MielecStal Mielec | 1 - 0 | Resovia RzeszówResovia Rzesz |
| 08 Jul 22 | r03 | CharleroiCharleroi | - | Paris FCParis FC |
| 08 Jul 22 | r03 | CeljeCelje | 5 - 1 | NaftaNafta |
| 08 Jul 22 | r03 | FC U Craiova 1948FC U Craiova | 5 - 0 | SlatinaSlatina |
| 08 Jul 22 | r03 | Widzew LodzWidzew Lodz | 6 - 2 | Stal RzeszówStal Rzeszów |
| 08 Jul 22 | r03 | CharleroiCharleroi | 1 - 2 | RFC SeraingRFC Seraing |
| 08 Jul 22 | r03 | Khimki FKKhimki FK | 0 - 0 | PFC SochiPFC Sochi |
| 08 Jul 22 | r03 | Arka GdyniaArka Gdynia | 0 - 0 | Chojniczanka ChojniceChojniczanka |
| 08 Jul 22 | r03 | Lommel SKLommel SK | 1 - 2 | WesterloWesterlo |
| 08 Jul 22 | r03 | SønderjyskeSønderjyske | 2 - 1 | AGF AarhusAGF Aarhus |
| 08 Jul 22 | r03 | Leyton OrientLeyton Orient | 0 - 3 | PeterboroPeterboro |
| 08 Jul 22 | r03 | LyngbyLyngby | 2 - 1 | KøgeKøge |
| 08 Jul 22 | r03 | AGF AarhusAGF Aarhus | 2 - 1 | SønderjyskeSønderjyske |
| 08 Jul 22 | r03 | Fortuna DüsseldorfFortuna Düsse | 1 - 5 | FC TwenteFC Twente |
| 08 Jul 22 | r03 | KV OostendeKV Oostende | 4 - 0 | KMSK DeinzeKMSK Deinze |
| 08 Jul 22 | r03 | Waasland-BeverenWaasland-Beve | - | KortrijkKortrijk |
| 08 Jul 22 | r03 | SV Josko RiedSV Josko Ried | 0 - 1 | SV HornSV Horn |
| 08 Jul 22 | r03 | FC WilFC Wil | - | Wacker InnsbruckWacker Innsbr |
| 08 Jul 22 | r03 | Freiburg IIFreiburg II | 0 - 3 | Stuttgarter KickersStuttgarter K |
| 08 Jul 22 | r03 | Alania VladikavkazAlania Vladik | 2 - 1 | SKA-KhabarovskSKA-Khabarovs |
| 08 Jul 22 | r03 | Jahn RegensburgJahn Regensbu | 2 - 1 | UnterhachingUnterhaching |
| 08 Jul 22 | r03 | NK BravoNK Bravo | - | LutonLuton |
| 08 Jul 22 | r03 | LensLens | 3 - 0 | ValenciennesValenciennes |
| 08 Jul 22 | r03 | OsnabrueckOsnabrueck | 4 - 1 | Rot Weiss AhlenRot Weiss Ahl |
| 08 Jul 22 | r03 | SK Vorwarts SteyrSK Vorwarts S | 1 - 5 | MotherwellMotherwell |
| 08 Jul 22 | r03 | FC Trenkwalder AdmiraFC Trenkwalde | 1 - 2 | Kisvárda FCKisvárda FC |
| 08 Jul 22 | r03 | VitesseVitesse | 0 - 0 | WesterloWesterlo |
| 08 Jul 22 | r03 | SC HeerenveenSC Heerenveen | 0 - 1 | FC UtrechtFC Utrecht |
| 08 Jul 22 | r03 | PaderbornPaderborn | 2 - 0 | BochumBochum |
| 08 Jul 22 | r03 | AugsburgAugsburg | 1 - 1 | SandhausenSandhausen |
| 08 Jul 22 | r03 | SV LafnitzSV Lafnitz | 0 - 2 | KF Vllaznia ShkodërKF Vllaznia S |
| 08 Jul 22 | r03 | Cracovia KrakowCracovia Krak | 2 - 1 | Hapoel Beer ShevaHapoel Beer S |
| 08 Jul 22 | r03 | SV Josko RiedSV Josko Ried | 2 - 4 | Újpest FCÚjpest FC |
| 08 Jul 22 | r03 | Farul ConstantaFarul Constan | 1 - 1 | CSA Steaua BucureştiCSA Steaua Bu |
| 08 Jul 22 | r03 | FC Spartak TrnavaFC Spartak Tr | 0 - 0 | Banik OstravaBanik Ostrava |
| 08 Jul 22 | r03 | SC Rheindorf AltachSC Rheindorf | 1 - 1 | FC WinterthurFC Winterthur |
| 08 Jul 22 | r03 | Austria LustenauAustria Luste | 0 - 4 | FC KolnFC Koln |
| 08 Jul 22 | r03 | Zaglebie LubinZaglebie Lubi | 1 - 0 | Chrobry GłogówChrobry Głogó |
| 08 Jul 22 | r03 | ServetteServette | 0 - 2 | West HamWest Ham |
| 08 Jul 22 | r03 | ZFC MeuselwitzZFC Meuselwit | 3 - 1 | Kaan-MarienbornKaan-Marienbo |
| 08 Jul 22 | r03 | Viktoria PlzenViktoria Plze | 1 - 3 | St.TruidenSt.Truiden |
| 08 Jul 22 | r03 | Legia WarsawLegia Warsaw | 2 - 1 | ZoryaZorya |
| 08 Jul 22 | r03 | FC KolnFC Koln | 4 - 0 | Austria LustenauAustria Luste |
| 08 Jul 22 | r03 | First ViennaFirst Vienna | 3 - 2 | Donaufeld WienDonaufeld Wie |
| 08 Jul 22 | r03 | SC VerlSC Verl | 3 - 1 | SC Heracles AlmeloSC Heracles A |
| 08 Jul 22 | r03 | PEC ZwollePEC Zwolle | 0 - 0 | FC EmmenFC Emmen |
| 08 Jul 22 | r03 | DürenDüren | 4 - 2 | DuisburgDuisburg |
| 08 Jul 22 | r03 | Nottingham ForestNottingham Fo | 1 - 3 | CoventryCoventry |
| 08 Jul 22 | r03 | CottbusCottbus | 1 - 5 | HerthaHertha |
| 08 Jul 22 | r03 | YorkYork | 2 - 3 | MiddlesbroughMiddlesbrough |
| 08 Jul 22 | r03 | SSV JeddelohSSV Jeddeloh | 1 - 0 | Kickers EmdenKickers Emden |
| 08 Jul 22 | r03 | Casa PiaCasa Pia | 1 - 2 | Sheffield UnitedSheffield Uni |
| 08 Jul 22 | r03 | SC HeerenveenSC Heerenveen | - | Blau-Weiß LohneBlau-Weiß Loh |
| 08 Jul 22 | r03 | SKU AmstettenSKU Amstetten | 4 - 0 | Wiener SCWiener SC |
| 08 Jul 22 | r03 | WeizWeiz | 1 - 5 | SV LafnitzSV Lafnitz |
| 08 Jul 22 | r03 | TSV BuchbachTSV Buchbach | 1 - 0 | Union GurtenUnion Gurten |
| 08 Jul 22 | r03 | Neusiedl am SeeNeusiedl am S | 0 - 3 | Floridsdorfer ACFloridsdorfer |
| 08 Jul 22 | r03 | Marchfeld DonauauenMarchfeld Don | 2 - 1 | Austria Vienna (Am)Austria Vienn |
| 08 Jul 22 | r03 | Harrogate Town FCHarrogate Tow | 0 - 2 | Sheffield WedsSheffield Wed |
| 08 Jul 22 | r03 | Arges PitestiArges Pitesti | 2 - 2 | CS MioveniCS Mioveni |
| 08 Jul 22 | r03 | MFK Zemplín MichalovceMFK Zemplín M | 2 - 0 | Tatran PresovTatran Presov |
| 08 Jul 22 | r03 | Civil Service StrollersCivil Service | 1 - 1 | St JohnstoneSt Johnstone |
| 08 Jul 22 | r03 | Bracknell TownBracknell Tow | 2 - 0 | WycombeWycombe |
| 08 Jul 22 | r03 | Taunton TownTaunton Town | 1 - 2 | ExeterExeter |
| 08 Jul 22 | r03 | AveleyAveley | 0 - 1 | Dagenham & Red.Dagenham & Re |
| 09 Jul 22 | r03 | Gornik ZabrzeGornik Zabrze | 0 - 1 | Warta PoznańWarta Poznań |
| 09 Jul 22 | r03 | FredericiaFredericia | - | Skive IKSkive IK |
| 09 Jul 22 | r03 | MechelenMechelen | - | Helmond SportHelmond Sport |
| 09 Jul 22 | r03 | RadomljeRadomlje | - | GoricaGorica |
| 09 Jul 22 | r03 | TáborskoTáborsko | - | PribramPribram |
| 09 Jul 22 | r03 | PetrolulPetrolul | 1 - 1 | Chindia TârgovișteChindia Târgo |
| 09 Jul 22 | r03 | PFC Kuban KrasnodarPFC Kuban Kra | 2 - 1 | FC Druzhba MaykopFC Druzhba Ma |
| 09 Jul 22 | r03 | Zaglebie LubinZaglebie Lubi | 3 - 1 | AaBAaB |
| 09 Jul 22 | r03 | Khimki FKKhimki FK | 4 - 2 | FC Yenisey KrasnoyarskFC Yenisey Kr |
| 09 Jul 22 | r03 | Rudar VelenjeRudar Velenje | 0 - 0 | Kecskeméti TEKecskeméti TE |
| 09 Jul 22 | r03 | WolvesWolves | 3 - 0 | BurnleyBurnley |
| 09 Jul 22 | r03 | SwanseaSwansea | 3 - 2 | Forest Green RoversForest Green |
| 09 Jul 22 | r03 | Oud-Heverlee LeuvenOud-Heverlee | 1 - 1 | Fortuna SittardFortuna Sitta |
| 09 Jul 22 | r03 | Maccabi NetanyaMaccabi Netan | 1 - 0 | VasasVasas |
| 09 Jul 22 | r03 | St EtienneSt Etienne | 3 - 0 | Thonon Évian F.C.Thonon Évian |
| 09 Jul 22 | r03 | PortimonensePortimonense | 0 - 2 | MonacoMonaco |
| 09 Jul 22 | r03 | TSV HartbergTSV Hartberg | 1 - 2 | Zalaegerszegi TEZalaegerszegi |
| 09 Jul 22 | r03 | KrkaKrka | 2 - 2 | GoricaGorica |
| 09 Jul 22 | r03 | FC PortoFC Porto | 3 - 0 | Bristol RoversBristol Rover |
| 09 Jul 22 | r03 | BoltonBolton | 0 - 1 | WiganWigan |
| 09 Jul 22 | r03 | Fakel VoronezhFakel Voronez | - | Torpedo MoscowTorpedo Mosco |
| 09 Jul 22 | r03 | Mezőkövesdi SEMezőkövesdi S | 2 - 3 | DiosgyorDiosgyor |
| 09 Jul 22 | r03 | Uta AradUta Arad | 2 - 1 | Ripensia TimisoaraRipensia Timi |
| 09 Jul 22 | r03 | Universitatea ClujUniversitatea | 4 - 1 | Minaur Baia MareMinaur Baia M |
| 09 Jul 22 | r03 | ChrudimChrudim | 0 - 4 | Dukla PrahaDukla Praha |
| 09 Jul 22 | r03 | FK PohronieFK Pohronie | 1 - 2 | Dukla Banská BystricaDukla Banská |
| 09 Jul 22 | r03 | NiceNice | 1 - 1 | Cercle BruggeCercle Brugge |
| 09 Jul 22 | r03 | SlovackoSlovacko | 2 - 0 | VyškovVyškov |
| 09 Jul 22 | r03 | Hradec KrálovéHradec Králov | 2 - 1 | Sparta Prague BSparta Prague |
| 09 Jul 22 | r03 | PardubicePardubice | 2 - 2 | Sigma Olomouc BSigma Olomouc |
| 09 Jul 22 | r03 | Podbeskidzie Bielsko-BialPodbeskidzie | 3 - 2 | Wisla KrakowWisla Krakow |
| 09 Jul 22 | r03 | ZlínZlín | 2 - 1 | TrencinTrencin |
| 09 Jul 22 | r03 | Paksi FCPaksi FC | 3 - 1 | III Kerületi TVEIII Kerületi |
| 09 Jul 22 | r03 | Odra OpoleOdra Opole | 1 - 1 | SFC OpavaSFC Opava |
| 09 Jul 22 | r03 | Banik OstravaBanik Ostrava | 1 - 3 | MSK ZilinaMSK Zilina |
| 09 Jul 22 | r03 | JastrzębieJastrzębie | 2 - 1 | Skra CzęstochowaSkra Częstoch |
| 09 Jul 22 | r03 | Dynamo České BudějoviceDynamo České | 6 - 3 | VlašimVlašim |
| 09 Jul 22 | r03 | JablonecJablonec | 1 - 2 | VarnsdorfVarnsdorf |
| 09 Jul 22 | r03 | ProstějovProstějov | 1 - 0 | LíšeňLíšeň |
| 09 Jul 22 | r03 | TOP OssTOP Oss | - | PAOKPAOK |
| 09 Jul 22 | r03 | RadomljeRadomlje | 0 - 1 | HNK GoricaHNK Gorica |
| 09 Jul 22 | r03 | LorientLorient | 1 - 0 | ConcarneauConcarneau |
| 09 Jul 22 | r03 | Wisla KrakowWisla Krakow | 3 - 2 | Podbeskidzie Bielsko-BialPodbeskidzie |
| 09 Jul 22 | r03 | LiberecLiberec | 3 - 0 | Miedz LegnicaMiedz Legnica |
| 09 Jul 22 | r03 | Atlas DelmenhorstAtlas Delmenh | 2 - 0 | Schwarz-Weiß RehdenSchwarz-Weiß |
| 09 Jul 22 | r03 | Tychy 71Tychy 71 | 0 - 0 | GKS KatowiceGKS Katowice |
| 09 Jul 22 | r03 | HillerødHillerød | 0 - 0 | FC HelsingoerFC Helsingoer |
| 09 Jul 22 | r03 | Jagiellonia BialystokJagiellonia B | 1 - 2 | Rukh LvivRukh Lviv |
| 09 Jul 22 | r03 | Ural S.RUral S.R | - | Krylya Sovetov SamaraKrylya Soveto |
| 09 Jul 22 | r03 | Club BruggeClub Brugge | 2 - 4 | FC CopenhagenFC Copenhagen |
| 09 Jul 22 | r03 | Saturn RamenskoyeSaturn Ramens | - | Torpedo MoscowTorpedo Mosco |
| 09 Jul 22 | r03 | HOBROHOBRO | 2 - 2 | Vendsyssel FFVendsyssel FF |
| 09 Jul 22 | r03 | Preußen MünsterPreußen Münst | 1 - 2 | SC Heracles AlmeloSC Heracles A |
| 09 Jul 22 | r03 | Odense BKOdense BK | 2 - 3 | Vejle BoldklubVejle Boldklu |
| 09 Jul 22 | r03 | ViborgViborg | 5 - 4 | AC HorsensAC Horsens |
| 09 Jul 22 | r03 | Raith RvsRaith Rvs | 4 - 0 | AlloaAlloa |
| 09 Jul 22 | r03 | PaderbornPaderborn | 2 - 0 | OsnabrueckOsnabrueck |
| 09 Jul 22 | r03 | NewcastleNewcastle | 5 - 1 | Gateshead FCGateshead FC |
| 09 Jul 22 | r03 | VSG AltglienickeVSG Altglieni | 6 - 0 | Optik RathenowOptik Ratheno |
| 09 Jul 22 | r03 | Schalke 04Schalke 04 | 1 - 3 | SV MeppenSV Meppen |
| 09 Jul 22 | r03 | OberneulandOberneuland | 1 - 4 | Hannover IIHannover II |
| 09 Jul 22 | r03 | Randers FCRanders FC | 1 - 1 | FredericiaFredericia |
| 09 Jul 22 | r03 | Young BoysYoung Boys | 7 - 0 | SchaffhausenSchaffhausen |
| 09 Jul 22 | r03 | Holstein KielHolstein Kiel | - | Silkeborg IFSilkeborg IF |
| 09 Jul 22 | r03 | North LeighNorth Leigh | 1 - 3 | Oxford UtdOxford Utd |
| 09 Jul 22 | r03 | VaduzVaduz | 3 - 1 | DornbirnDornbirn |
| 09 Jul 22 | r03 | Puszcza NiepołomicePuszcza Niepo | 0 - 1 | Ruch ChorzowRuch Chorzow |
| 09 Jul 22 | r03 | Tatran Liptovský MikulášTatran Liptov | 0 - 0 | KarvinaKarvina |
| 09 Jul 22 | r03 | WalsallWalsall | 0 - 4 | Aston VillaAston Villa |
| 09 Jul 22 | r03 | Wehen WiesbadenWehen Wiesbad | 1 - 0 | TSV Steinbach HaigerTSV Steinbach |
| 09 Jul 22 | r03 | Hallescher FCHallescher FC | 1 - 2 | TepliceTeplice |
| 09 Jul 22 | r03 | HannoverHannover | 3 - 0 | FC GroningenFC Groningen |
| 09 Jul 22 | r03 | CardiffCardiff | 3 - 2 | Cambridge UnitedCambridge Uni |
| 09 Jul 22 | r03 | St JohnstoneSt Johnstone | 3 - 2 | Cove RangersCove Rangers |
| 09 Jul 22 | r03 | DoverDover | 2 - 0 | GillinghamGillingham |
| 09 Jul 22 | r03 | KarlsruheKarlsruhe | - | FC SaarbrückenFC Saarbrücke |
| 09 Jul 22 | r03 | NurnbergNurnberg | 2 - 1 | FC SchweinfurtFC Schweinfur |
| 09 Jul 22 | r03 | FC LieferingFC Liefering | 1 - 3 | Bayern Munich IIBayern Munich |
| 09 Jul 22 | r03 | Nurnberg IINurnberg II | - | Sonnenhof GroßaspachSonnenhof Gro |
| 09 Jul 22 | r03 | IngolstadtIngolstadt | 2 - 2 | TSV Rain am LechTSV Rain am L |
| 09 Jul 22 | r03 | LeicesterLeicester | 1 - 2 | Notts CountyNotts County |
| 09 Jul 22 | r03 | Slough TownSlough Town | 1 - 2 | WealdstoneWealdstone |
| 09 Jul 22 | r03 | Hansa RostockHansa Rostock | 3 - 1 | BrøndbyBrøndby |
| 09 Jul 22 | r03 | Wuerzburger KickersWuerzburger K | 1 - 1 | FSV FrankfurtFSV Frankfurt |
| 09 Jul 22 | r03 | Waldhof MannheimWaldhof Mannh | 0 - 1 | ElversbergElversberg |
| 09 Jul 22 | r03 | Jahn RegensburgJahn Regensbu | 2 - 2 | NorwichNorwich |
| 09 Jul 22 | r03 | Hessen KasselHessen Kassel | 1 - 5 | WiedenbrückWiedenbrück |
| 09 Jul 22 | r03 | AueAue | 2 - 2 | SpVgg Greuther Fürth IISpVgg Greuthe |
| 09 Jul 22 | r03 | MagdeburgMagdeburg | 4 - 2 | SC CambuurSC Cambuur |
| 09 Jul 22 | r03 | Crystal PalaceCrystal Palac | 5 - 4 | MillwallMillwall |
| 09 Jul 22 | r03 | Werder Bremen IIWerder Bremen | 3 - 2 | BocholtBocholt |
| 09 Jul 22 | r03 | Willem IIWillem II | 2 - 0 | SC TelstarSC Telstar |
| 09 Jul 22 | r03 | NEC NijmegenNEC Nijmegen | 3 - 1 | RKC WaalwijkRKC Waalwijk |
| 09 Jul 22 | r03 | De GraafschapDe Graafschap | 1 - 3 | Rot-Weiß OberhausenRot-Weiß Ober |
| 09 Jul 22 | r03 | BinfieldBinfield | 1 - 4 | Maidenhead UnitedMaidenhead Un |
| 09 Jul 22 | r03 | FC VolendamFC Volendam | 3 - 2 | GenkGenk |
| 09 Jul 22 | r03 | VV KatwijkVV Katwijk | 0 - 5 | Jong AZJong AZ |
| 09 Jul 22 | r03 | St. GallenSt. Gallen | 3 - 4 | FreiburgFreiburg |
| 09 Jul 22 | r03 | Nizhny NovgorodNizhny Novgor | 1 - 0 | Akron TolyattiAkron Tolyatt |
| 09 Jul 22 | r03 | Carl Zeiss JenaCarl Zeiss Je | 3 - 0 | TSV AubstadtTSV Aubstadt |
| 09 Jul 22 | r03 | FC KolnFC Koln | 1 - 1 | GrasshoppersGrasshoppers |
| 09 Jul 22 | r03 | LASKLASK | 0 - 0 | Ein FrankfurtEin Frankfurt |
| 09 Jul 22 | r03 | NewportNewport | - | Hungerford TownHungerford To |
| 09 Jul 22 | r03 | OldenburgOldenburg | 1 - 1 | Go Ahead EaglesGo Ahead Eagl |
| 09 Jul 22 | r03 | Wolfsberger ACWolfsberger A | 1 - 0 | Sparta PragueSparta Prague |
| 09 Jul 22 | r03 | LeverkusenLeverkusen | 6 - 1 | DuisburgDuisburg |
| 09 Jul 22 | r03 | KnockbredaKnockbreda | 1 - 2 | LinfieldLinfield |
| 09 Jul 22 | r03 | VVV-VenloVVV-Venlo | 0 - 3 | Mgladbach IIMgladbach II |
| 09 Jul 22 | r03 | Roda JCRoda JC | 5 - 2 | AachenAachen |
| 09 Jul 22 | r03 | AccringtonAccrington | 1 - 0 | BlackburnBlackburn |
| 09 Jul 22 | r03 | SSV JeddelohSSV Jeddeloh | 2 - 1 | VfL OldenburgVfL Oldenburg |
| 09 Jul 22 | r03 | Cleethorpes TownCleethorpes T | 0 - 2 | GrimsbyGrimsby |
| 09 Jul 22 | r03 | KV OostendeKV Oostende | 3 - 1 | WaregemWaregem |
| 09 Jul 22 | r03 | KaiserslauternKaiserslauter | 4 - 1 | EupenEupen |
| 09 Jul 22 | r03 | MechelenMechelen | 1 - 0 | Maccabi HaifaMaccabi Haifa |
| 09 Jul 22 | r03 | HoffenheimHoffenheim | 2 - 0 | FC HeidenheimFC Heidenheim |
| 09 Jul 22 | r03 | Maidenhead UnitedMaidenhead Un | 1 - 4 | BinfieldBinfield |
| 09 Jul 22 | r03 | Rot-Weiss EssenRot-Weiss Ess | - | BraunschweigBraunschweig |
| 09 Jul 22 | r03 | Union BerlinUnion Berlin | 2 - 1 | BohemiansBohemians |
| 09 Jul 22 | r03 | Piast GliwicePiast Gliwice | 1 - 2 | Sigma OlomoucSigma Olomouc |
| 09 Jul 22 | r03 | Sturm GrazSturm Graz | 0 - 0 | Zbrojovka BrnoZbrojovka Brn |
| 09 Jul 22 | r03 | Hemel Hempstead Town FCHemel Hempste | 0 - 2 | BarnetBarnet |
| 09 Jul 22 | r03 | Dorking WanderersDorking Wande | 5 - 2 | FarnboroughFarnborough |
| 09 Jul 22 | r03 | Kings LangleyKings Langley | 0 - 4 | SouthendSouthend |
| 09 Jul 22 | r03 | BarnsleyBarnsley | 0 - 0 | CreweCrewe |
| 09 Jul 22 | r03 | Zaglebie SosnowiecZaglebie Sosn | 2 - 2 | TřinecTřinec |
| 09 Jul 22 | r03 | FC EindhovenFC Eindhoven | 1 - 0 | Jong PSVJong PSV |
| 09 Jul 22 | r03 | Bath CityBath City | 0 - 0 | CheltenhamCheltenham |
| 09 Jul 22 | r03 | DartfordDartford | 1 - 6 | CharltonCharlton |
| 09 Jul 22 | r03 | Warrington RylandsWarrington Ry | 2 - 7 | Salford CitySalford City |
| 09 Jul 22 | r03 | Havant & WaterloovilleHavant & Wate | 1 - 2 | Sutton UnitedSutton United |
| 09 Jul 22 | r03 | WorkingtonWorkington | 0 - 3 | CarlisleCarlisle |
| 09 Jul 22 | r03 | Swindon SupermarineSwindon Super | 2 - 0 | SwindonSwindon |
| 09 Jul 22 | r03 | Chester CityChester City | 0 - 1 | RochdaleRochdale |
| 09 Jul 22 | r03 | Nuneaton TownNuneaton Town | 0 - 2 | DoncasterDoncaster |
| 09 Jul 22 | r03 | Boreham WoodBoreham Wood | 0 - 2 | BrentfordBrentford |
| 09 Jul 22 | r03 | Eastbourne BoroughEastbourne Bo | 1 - 0 | AFC WimbledonAFC Wimbledon |
| 09 Jul 22 | r03 | Bamber BridgeBamber Bridge | 0 - 0 | OldhamOldham |
| 09 Jul 22 | r03 | StevenageStevenage | 2 - 0 | West BromWest Brom |
| 09 Jul 22 | r03 | KortrijkKortrijk | 0 - 0 | VirtonVirton |
| 09 Jul 22 | r03 | Barockstadt Fulda-LehnerzBarockstadt F | 3 - 1 | FC GießenFC Gießen |
| 09 Jul 22 | r03 | Limavady UnitedLimavady Unit | 0 - 5 | ColeraineColeraine |
| 09 Jul 22 | r03 | Warrington TownWarrington To | 0 - 1 | TranmereTranmere |
| 09 Jul 22 | r03 | Szombathelyi HaladásSzombathelyi | 1 - 2 | Rapid Wien IIRapid Wien II |
| 09 Jul 22 | r03 | Gosport BoroughGosport Borou | 1 - 6 | EastleighEastleigh |
| 09 Jul 22 | r03 | BradfordBradford | 0 - 2 | DerbyDerby |
| 09 Jul 22 | r03 | CrawleyCrawley | 3 - 3 | QPRQPR |
| 09 Jul 22 | r03 | PortsmouthPortsmouth | 2 - 0 | Qatar SCQatar SC |
| 09 Jul 22 | r03 | Ballymena UnitedBallymena Uni | 4 - 1 | PortstewartPortstewart |
| 09 Jul 22 | r03 | Bonnyrigg Rose AthleticBonnyrigg Ros | 0 - 5 | HeartsHearts |
| 09 Jul 22 | r03 | FC Krasnodar-2FC Krasnodar- | 2 - 0 | FC Chernomorets NovorossiFC Chernomore |
| 09 Jul 22 | r03 | Eintracht TrierEintracht Tri | 5 - 3 | FolaFola |
| 09 Jul 22 | r03 | MacclesfieldMacclesfield | 2 - 2 | MorecambeMorecambe |
| 09 Jul 22 | r03 | BavoisBavois | 1 - 9 | Yverdon SportYverdon Sport |
| 09 Jul 22 | r03 | Sheppey UnitedSheppey Unite | 1 - 5 | MaidstoneMaidstone |
| 09 Jul 22 | r03 | ThunThun | 0 - 1 | FC Lausanne-SportFC Lausanne-S |
| 09 Jul 22 | r03 | BurtonBurton | - | BurnleyBurnley |
| 09 Jul 22 | r03 | FK Železiarne PodbrezováFK Železiarne | 2 - 1 | KosiceKosice |
| 09 Jul 22 | r03 | Young BoysYoung Boys | 1 - 1 | SPVGG Greuther FürthSPVGG Greuthe |
| 09 Jul 22 | r03 | VirtonVirton | 0 - 0 | KortrijkKortrijk |
| 09 Jul 22 | r03 | SKN St. PoltenSKN St. Polte | 1 - 3 | Bohemians 1905Bohemians 190 |
| 09 Jul 22 | r03 | Mlada BoleslavMlada Bolesla | 4 - 1 | Vysočina JihlavaVysočina Jihl |
| 09 Jul 22 | r03 | LKS LodzLKS Lodz | - | Tychy 71Tychy 71 |
| 09 Jul 22 | r03 | ReadingReading | 0 - 2 | BenficaBenfica |
| 09 Jul 22 | r03 | AuxerreAuxerre | 2 - 3 | AmiensAmiens |
| 09 Jul 22 | r03 | MTK HungariaMTK Hungaria | - | VasasVasas |
| 09 Jul 22 | r03 | VasasVasas | 1 - 0 | DebrecenDebrecen |
| 09 Jul 22 | r03 | BanburyBanbury | 1 - 2 | Oxford UtdOxford Utd |
| 09 Jul 22 | r03 | GrenobleGrenoble | 1 - 0 | Clermont FootClermont Foot |
| 09 Jul 22 | r03 | LavalLaval | 1 - 2 | GuingampGuingamp |
| 09 Jul 22 | r03 | AnnecyAnnecy | 2 - 0 | NimesNimes |
| 09 Jul 22 | r03 | Stade de ReimsStade de Reim | 1 - 2 | Paris 13 AtleticoParis 13 Atle |
| 09 Jul 22 | r03 | DijonDijon | 6 - 0 | FC VillefrancheFC Villefranc |
| 09 Jul 22 | r03 | Zimbru ChisinauZimbru Chisin | 0 - 3 | ChornomoretsChornomorets |
| 09 Jul 22 | r03 | Stade Lausanne OuchyStade Lausann | 7 - 0 | Étoile CarougeÉtoile Caroug |
| 09 Jul 22 | r03 | StuttgartStuttgart | 3 - 2 | ZurichZurich |
| 09 Jul 22 | r03 | StrasbourgStrasbourg | 2 - 1 | FC SionFC Sion |
| 09 Jul 22 | r03 | QuevillyQuevilly | 1 - 2 | Le HavreLe Havre |
| 09 Jul 22 | r03 | WSG Swarovski TirolWSG Swarovski | 1 - 7 | WolfsburgWolfsburg |
| 09 Jul 22 | r03 | Kispest HonvedKispest Honve | 0 - 1 | NK VaraždinNK Varaždin |
| 09 Jul 22 | r03 | NK AluminijNK Aluminij | 1 - 2 | DomzaleDomzale |
| 09 Jul 22 | r03 | ToulouseToulouse | 6 - 1 | TroyesTroyes |
| 09 Jul 22 | r03 | BrestBrest | 1 - 0 | US AvranchesUS Avranches |
| 09 Jul 22 | r03 | Cork City FCCork City FC | 0 - 2 | StokeStoke |
| 09 Jul 22 | r03 | Gornik ZabrzeGornik Zabrze | 2 - 1 | AaBAaB |
| 09 Jul 22 | r03 | ViOn Zlaté MoravceViOn Zlaté Mo | 6 - 0 | FC PetržalkaFC Petržalka |
| 09 Jul 22 | r03 | FC AarauFC Aarau | - | Neuchâtel XamaxNeuchâtel Xam |
| 09 Jul 22 | r03 | LKS LodzLKS Lodz | 1 - 1 | Znicz PruszkówZnicz Pruszkó |
| 09 Jul 22 | r03 | MetzMetz | 2 - 0 | Racing FC Union LuxembourRacing FC Uni |
| 09 Jul 22 | r03 | CaenCaen | 1 - 0 | AjaccioAjaccio |
| 09 Jul 22 | r03 | Rapid ViennaRapid Vienna | 3 - 3 | CelticCeltic |
| 09 Jul 22 | r03 | LucerneLucerne | 1 - 2 | Dynamo KievDynamo Kiev |
| 09 Jul 22 | r03 | FC Krasnodar-2FC Krasnodar- | 1 - 1 | PFC Kuban KrasnodarPFC Kuban Kra |
| 09 Jul 22 | r03 | SkalicaSkalica | - | Spartak MyjavaSpartak Myjav |
| 09 Jul 22 | r03 | CeljeCelje | 1 - 0 | NyíregyházaNyíregyháza |
| 09 Jul 22 | r03 | NAC BredaNAC Breda | - | ExcelsiorExcelsior |
| 09 Jul 22 | r03 | Otelul GalatiOtelul Galati | 0 - 1 | Steaua BucurestiSteaua Bucure |
| 09 Jul 22 | r03 | BrightonBrighton | 0 - 0 | St. GilloiseSt. Gilloise |
| 09 Jul 22 | r03 | MontpellierMontpellier | 0 - 1 | Rodez AFRodez AF |
| 09 Jul 22 | r03 | Bourg-PeronnasBourg-Peronna | 2 - 4 | LyonLyon |
| 09 Jul 22 | r03 | LeobenLeoben | 3 - 1 | Grazer AKGrazer AK |
| 09 Jul 22 | r03 | OlympiakosOlympiakos | 1 - 0 | AZ AlkmaarAZ Alkmaar |
| 09 Jul 22 | r03 | GentGent | 2 - 1 | FC MidtjyllandFC Midtjyllan |
| 09 Jul 22 | r03 | RijekaRijeka | 1 - 2 | KoperKoper |
| 09 Jul 22 | r03 | SunderlandSunderland | - | RangersRangers |
| 10 Jul 22 | r03 | Vejle BoldklubVejle Boldklu | 0 - 1 | Kolding IFKolding IF |
| 10 Jul 22 | r03 | BrøndbyBrøndby | 2 - 0 | Fremad AmagerFremad Amager |
| 10 Jul 22 | r03 | Khimki FKKhimki FK | - | Lok. MoscowLok. Moscow |
| 10 Jul 22 | r03 | Hamburg IIHamburg II | 0 - 2 | Schalke 04 IISchalke 04 II |
| 10 Jul 22 | r03 | Berliner AK 07Berliner AK 0 | 2 - 0 | TSV HavelseTSV Havelse |
| 10 Jul 22 | r03 | PanathinaikosPanathinaikos | 0 - 0 | WatfordWatford |
| 10 Jul 22 | r03 | Hallescher FCHallescher FC | 0 - 2 | Chemnitzer FCChemnitzer FC |
| 10 Jul 22 | r03 | Munich 1860Munich 1860 | 0 - 6 | MönchengladbachMönchengladba |
| 10 Jul 22 | r03 | GlentoranGlentoran | 6 - 3 | Rangers BRangers B |
| 10 Jul 22 | r03 | Slavia PragueSlavia Prague | 1 - 0 | Puskás Akadémia FCPuskás Akadém |
| 10 Jul 22 | r03 | FK Rubin KazanFK Rubin Kaza | 1 - 4 | FC UfaFC Ufa |
| 10 Jul 22 | r03 | AngersAngers | 2 - 1 | NiortNiort |
| 10 Jul 22 | r03 | Tabor SežanaTabor Sežana | 2 - 1 | FC Politehnica TimisoaraFC Politehnic |
| 10 Jul 22 | r03 | Videoton FC FehervarVideoton FC F | 2 - 1 | Aris LimassolAris Limassol |
| 10 Jul 22 | r03 | Austria SalzburgAustria Salzb | 0 - 5 | Dortmund IIDortmund II |
| 10 Jul 22 | r03 | FK RostovFK Rostov | 1 - 2 | FC KrasnodarFC Krasnodar |
| 10 Jul 22 | r03 | Lok. MoscowLok. Moscow | - | Dinamo MoscowDinamo Moscow |
| 10 Jul 22 | r03 | MornarMornar | - | UrartuUrartu |
| 10 Jul 22 | r03 | BellinzonaBellinzona | 0 - 0 | MonzaMonza |
| 10 Jul 22 | r03 | Doxa KatokopiasDoxa Katokopi | 1 - 0 | Apollon LimassolApollon Limas |
| 10 Jul 22 | r03 | KoperKoper | 2 - 1 | PrimorjePrimorje |
| 11 Jul 22 | r03 | Arsenal TivatArsenal Tivat | 2 - 5 | Paksi FCPaksi FC |
| 11 Jul 22 | r03 | FC Anzhi MakhachkalaFC Anzhi Makh | 3 - 0 | FC Legion Dynamo MakhachkFC Legion Dyn |
| 11 Jul 22 | r03 | ArisAris | 2 - 1 | OlympiakosOlympiakos |
| 11 Jul 22 | r03 | East Grinstead TownEast Grinstea | 0 - 9 | CrawleyCrawley |
| 11 Jul 22 | r03 | Beaconsfield TownBeaconsfield | 4 - 4 | WealdstoneWealdstone |
| 12 Jul 22 | r03 | CarlisleCarlisle | 1 - 1 | MortonMorton |
| 12 Jul 22 | r03 | BastiaBastia | - | AS BeziersAS Beziers |
| 12 Jul 22 | r03 | Helmond SportHelmond Sport | 0 - 2 | AnderlechtAnderlecht |
| 12 Jul 22 | r03 | CoventryCoventry | 1 - 0 | Forest Green RoversForest Green |
| 12 Jul 22 | r03 | Excelsior MaassluisExcelsior Maa | 0 - 0 | SC TelstarSC Telstar |
| 12 Jul 22 | r03 | Potters Bar TownPotters Bar T | 2 - 0 | Leyton OrientLeyton Orient |
| 12 Jul 22 | r03 | Chippenham Town FCChippenham To | 1 - 4 | Bristol RoversBristol Rover |
| 12 Jul 22 | r03 | Stratford TownStratford Tow | 1 - 2 | CheltenhamCheltenham |
| 12 Jul 22 | r03 | ColchesterColchester | 2 - 4 | CharltonCharlton |
| 12 Jul 22 | r03 | Dorking WanderersDorking Wande | 4 - 2 | Hanwell TownHanwell Town |
| 12 Jul 22 | r03 | Kryvbas Kryvyi RihKryvbas Kryvy | 1 - 1 | FC OlexandriaFC Olexandria |
| 12 Jul 22 | r03 | Bourg-PeronnasBourg-Peronna | 0 - 0 | SochauxSochaux |
| 12 Jul 22 | r03 | GetafeGetafe | 2 - 1 | PrestonPreston |
| 12 Jul 22 | r03 | GentGent | 2 - 2 | Waasland-BeverenWaasland-Beve |
| 12 Jul 22 | r03 | LincolnLincoln | - | Sheffield UnitedSheffield Uni |
| 12 Jul 22 | r03 | ReadingReading | - | Maidenhead UnitedMaidenhead Un |
| 12 Jul 22 | r03 | VarnsdorfVarnsdorf | - | Ústí nad LabemÚstí nad Labe |
| 12 Jul 22 | r03 | RKC WaalwijkRKC Waalwijk | 7 - 3 | PEC ZwollePEC Zwolle |
| 12 Jul 22 | r03 | Huddersfield TownHuddersfield | 3 - 1 | MorecambeMorecambe |
| 12 Jul 22 | r03 | Bristol CityBristol City | 0 - 0 | PortsmouthPortsmouth |
| 12 Jul 22 | r03 | WatfordWatford | 0 - 2 | BoltonBolton |
| 12 Jul 22 | r03 | Hvidovre IFHvidovre IF | 0 - 1 | B.93B.93 |
| 12 Jul 22 | r03 | Újpest FCÚjpest FC | 0 - 1 | Bohemians 1905Bohemians 190 |
| 12 Jul 22 | r03 | FC BaselFC Basel | - | StrasbourgStrasbourg |
| 12 Jul 22 | r03 | VitesseVitesse | 1 - 0 | Maccabi HaifaMaccabi Haifa |
| 12 Jul 22 | r03 | SedanSedan | 3 - 3 | MetzMetz |
| 12 Jul 22 | r03 | Paris FCParis FC | 3 - 1 | FC Versailles 78FC Versailles |
| 12 Jul 22 | r03 | ToulouseToulouse | - | Pau FCPau FC |
| 12 Jul 22 | r03 | Apoel NicosiaApoel Nicosia | 2 - 2 | AEK LarnacaAEK Larnaca |
| 12 Jul 22 | r03 | CaenCaen | 3 - 0 | Le MansLe Mans |
| 12 Jul 22 | r03 | Canet RoussillonCanet Roussil | 0 - 4 | BastiaBastia |
| 12 Jul 22 | r03 | Le Puy Foot 43Le Puy Foot 4 | 0 - 1 | St EtienneSt Etienne |
| 12 Jul 22 | r03 | WycombeWycombe | 0 - 0 | Oxford CityOxford City |
| 12 Jul 22 | r03 | BragaBraga | 3 - 2 | AroucaArouca |
| 12 Jul 22 | r03 | FC WinterthurFC Winterthur | 3 - 0 | BrühlBrühl |
| 12 Jul 22 | r03 | ExeterExeter | 3 - 0 | Truro CityTruro City |
| 12 Jul 22 | r03 | CardiffCardiff | 2 - 0 | NewportNewport |
| 12 Jul 22 | r03 | LyonLyon | 1 - 3 | Dynamo KievDynamo Kiev |
| 12 Jul 22 | r03 | WokingWoking | 0 - 4 | SwindonSwindon |
| 12 Jul 22 | r03 | PortimonensePortimonense | 1 - 1 | BirminghamBirmingham |
| 12 Jul 22 | r03 | IpswichIpswich | 1 - 2 | West HamWest Ham |
| 12 Jul 22 | r03 | Boreham WoodBoreham Wood | 1 - 1 | West HamWest Ham |
| 12 Jul 22 | r03 | ExcelsiorExcelsior | - | SC TelstarSC Telstar |
| 12 Jul 22 | r03 | BurtonBurton | 0 - 1 | Nottingham ForestNottingham Fo |
| 12 Jul 22 | r03 | Dunston UTSDunston UTS | 2 - 1 | Gateshead FCGateshead FC |
| 12 Jul 22 | r03 | Kings Lynn TownKings Lynn To | 0 - 2 | NorwichNorwich |
| 12 Jul 22 | r03 | CanveyCanvey | 0 - 7 | SouthendSouthend |
| 12 Jul 22 | r03 | PlymouthPlymouth | 1 - 1 | SwanseaSwansea |
| 12 Jul 22 | r03 | LeamingtonLeamington | 1 - 1 | WalsallWalsall |
| 12 Jul 22 | r03 | Marske UnitedMarske United | 0 - 3 | HartlepoolHartlepool |
| 12 Jul 22 | r03 | Bath CityBath City | 3 - 1 | Bristol RoversBristol Rover |
| 12 Jul 22 | r03 | ExmouthExmouth | 0 - 2 | TorquayTorquay |
| 12 Jul 22 | r03 | Halesowen TownHalesowen Tow | 2 - 3 | CreweCrewe |
| 12 Jul 22 | r03 | Taunton TownTaunton Town | 0 - 0 | YeovilYeovil |
| 12 Jul 22 | r03 | AFC Telford UnitedAFC Telford U | 0 - 0 | ShrewsburyShrewsbury |
| 12 Jul 22 | r03 | MaidstoneMaidstone | 0 - 0 | Leyton OrientLeyton Orient |
| 12 Jul 22 | r03 | Hungerford TownHungerford To | 1 - 2 | Oxford UtdOxford Utd |
| 12 Jul 22 | r03 | Wingate & FinchleyWingate & Fin | 1 - 5 | BarnetBarnet |
| 12 Jul 22 | r03 | TraffordTrafford | 0 - 2 | AltrinchamAltrincham |
| 12 Jul 22 | r03 | ChorleyChorley | 3 - 0 | Salford CitySalford City |
| 12 Jul 22 | r03 | Harrogate Town FCHarrogate Tow | 0 - 3 | RotherhamRotherham |
| 12 Jul 22 | r03 | WittonWitton | 1 - 4 | BarrowBarrow |
| 12 Jul 22 | r03 | DartfordDartford | 0 - 2 | MillwallMillwall |
| 12 Jul 22 | r03 | MatlockMatlock | 0 - 1 | MansfieldMansfield |
| 12 Jul 22 | r03 | AFC FyldeAFC Fylde | 1 - 0 | HalifaxHalifax |
| 12 Jul 22 | r03 | Alfreton TownAlfreton Town | 0 - 2 | Notts CountyNotts County |
| 13 Jul 22 | r03 | GuimaraesGuimaraes | 1 - 0 | TorreenseTorreense |
| 13 Jul 22 | r03 | NantesNantes | 0 - 1 | GuingampGuingamp |
| 13 Jul 22 | r03 | US AvranchesUS Avranches | 2 - 2 | Le HavreLe Havre |
| 13 Jul 22 | r03 | GuimaraesGuimaraes | - | MoreirenseMoreirense |
| 13 Jul 22 | r03 | FC BotoșaniFC Botoșani | 3 - 1 | Dacia BuiucaniDacia Buiucan |
| 13 Jul 22 | r03 | MoreirenseMoreirense | 0 - 0 | F.C. Paços de FerreiraF.C. Paços de |
| 13 Jul 22 | r03 | Fremad AmagerFremad Amager | 2 - 1 | FC HelsingoerFC Helsingoer |
| 13 Jul 22 | r03 | VasasVasas | 2 - 1 | KazincbarcikaKazincbarcika |
| 13 Jul 22 | r03 | ChavesChaves | 1 - 1 | Academico ViseuAcademico Vis |
| 13 Jul 22 | r03 | HOBROHOBRO | 3 - 0 | Skive IKSkive IK |
| 13 Jul 22 | r03 | FC HelsingoerFC Helsingoer | 2 - 2 | Fremad AmagerFremad Amager |
| 13 Jul 22 | r03 | AmiensAmiens | - | ValenciennesValenciennes |
| 13 Jul 22 | r03 | Club BruggeClub Brugge | 4 - 2 | FC UtrechtFC Utrecht |
| 13 Jul 22 | r03 | MechelenMechelen | 0 - 0 | MolenbeekMolenbeek |
| 13 Jul 22 | r03 | Hradec KrálovéHradec Králov | 2 - 3 | Dukla PrahaDukla Praha |
| 13 Jul 22 | r03 | VasasVasas | 1 - 1 | Zalaegerszegi TEZalaegerszegi |
| 13 Jul 22 | r03 | Sparta PragueSparta Prague | 1 - 1 | Paksi FCPaksi FC |
| 13 Jul 22 | r03 | Optik RathenowOptik Ratheno | 1 - 6 | Berliner AK 07Berliner AK 0 |
| 13 Jul 22 | r03 | ZFC MeuselwitzZFC Meuselwit | 2 - 3 | AueAue |
| 13 Jul 22 | r03 | BochumBochum | 3 - 2 | LecceLecce |
| 13 Jul 22 | r03 | Kispest HonvedKispest Honve | 2 - 2 | Arsenal TivatArsenal Tivat |
| 13 Jul 22 | r03 | AuxerreAuxerre | 3 - 2 | OrleansOrleans |
| 13 Jul 22 | r03 | Banik OstravaBanik Ostrava | 2 - 4 | CelticCeltic |
| 13 Jul 22 | r03 | VfV HildesheimVfV Hildeshei | 2 - 1 | Tennis Borussia BerlinTennis Boruss |
| 13 Jul 22 | r03 | ZwickauZwickau | 0 - 4 | QPRQPR |
| 13 Jul 22 | r03 | AngersAngers | 2 - 1 | SO CholetSO Cholet |
| 13 Jul 22 | r03 | OberachernOberachern | 0 - 6 | FC SaarbrückenFC Saarbrücke |
| 13 Jul 22 | r03 | SalernitanaSalernitana | 0 - 0 | Schalke 04Schalke 04 |
| 13 Jul 22 | r03 | GyirmótGyirmót | 0 - 4 | Mezőkövesdi SEMezőkövesdi S |
| 13 Jul 22 | r03 | AugsburgAugsburg | 0 - 1 | Dynamo České BudějoviceDynamo České |
| 13 Jul 22 | r03 | St.TruidenSt.Truiden | 0 - 2 | RFC SeraingRFC Seraing |
| 13 Jul 22 | r03 | SpVgg BayreuthSpVgg Bayreut | 0 - 2 | Lokomotive LeipzigLokomotive Le |
| 13 Jul 22 | r03 | KMSK DeinzeKMSK Deinze | - | CharleroiCharleroi |
| 13 Jul 22 | r03 | HoffenheimHoffenheim | 2 - 0 | Puskás Akadémia FCPuskás Akadém |
| 13 Jul 22 | r03 | Fortuna SittardFortuna Sitta | - | VirtonVirton |
| 13 Jul 22 | r03 | Gil VicenteGil Vicente | 2 - 0 | PenafielPenafiel |
| 13 Jul 22 | r03 | Lommel SKLommel SK | 1 - 2 | Stade de ReimsStade de Reim |
| 13 Jul 22 | r03 | Germania HalberstadtGermania Halb | 1 - 0 | Einheit WernigerodeEinheit Werni |
| 13 Jul 22 | r03 | Rot Weiss AhlenRot Weiss Ahl | 1 - 2 | SV MeppenSV Meppen |
| 13 Jul 22 | r03 | MönchengladbachMönchengladba | 5 - 2 | Viktoria KölnViktoria Köln |
| 13 Jul 22 | r03 | VVV-VenloVVV-Venlo | - | VirtonVirton |
| 13 Jul 22 | r03 | AccringtonAccrington | 2 - 0 | StokeStoke |
| 13 Jul 22 | r03 | MarseilleMarseille | 4 - 1 | Marignane GignacMarignane Gig |
| 13 Jul 22 | r03 | TOP OssTOP Oss | 2 - 0 | Jong AZJong AZ |
| 13 Jul 22 | r03 | SG Wattenscheid 09SG Wattensche | 3 - 1 | VfB HombergVfB Homberg |
| 13 Jul 22 | r03 | FC Koln IIFC Koln II | 5 - 0 | Bergisch Gladbach 09Bergisch Glad |
| 13 Jul 22 | r03 | AachenAachen | 2 - 0 | AalenAalen |
| 13 Jul 22 | r03 | Hyde UnitedHyde United | - | WiganWigan |
| 13 Jul 22 | r03 | Salford CitySalford City | 1 - 1 | RotherhamRotherham |
| 13 Jul 22 | r03 | Spennymoor Town FCSpennymoor To | 1 - 3 | DoncasterDoncaster |
| 13 Jul 22 | r03 | Sporting CPSporting CP | 1 - 1 | St. GilloiseSt. Gilloise |
| 13 Jul 22 | r03 | StevenageStevenage | 1 - 1 | PeterboroPeterboro |
| 13 Jul 22 | r03 | TranmereTranmere | - | HeartsHearts |
| 13 Jul 22 | r03 | Civil Service StrollersCivil Service | 4 - 1 | DunfermlineDunfermline |
| 13 Jul 22 | r03 | Atherton CollieriesAtherton Coll | - | BoltonBolton |
| 13 Jul 22 | r03 | EastleighEastleigh | 1 - 5 | Oxford UtdOxford Utd |
| 13 Jul 22 | r03 | NorthamptonNorthampton | 0 - 3 | West BromWest Brom |
| 13 Jul 22 | r03 | Dundee UnitedDundee United | - | BlackburnBlackburn |
| 13 Jul 22 | r03 | Dundee FCDundee FC | 1 - 1 | BlackburnBlackburn |
| 14 Jul 22 | r03 | BastiaBastia | - | Fréjus Saint-RaphaëlFréjus Saint- |
| 14 Jul 22 | r03 | DebrecenDebrecen | - | Aris LimassolAris Limassol |
| 14 Jul 22 | r03 | LazioLazio | 5 - 0 | DekaniDekani |
| 14 Jul 22 | r03 | Vitória de Guimarães BVitória de Gu | 6 - 5 | Santa ClaraSanta Clara |
| 14 Jul 22 | r03 | PortimonensePortimonense | 0 - 1 | FC PortoFC Porto |
| 14 Jul 22 | r03 | Auda KekavaAuda Kekava | 1 - 2 | Pafos FCPafos FC |
| 14 Jul 22 | r03 | Wolfsberger ACWolfsberger A | 2 - 1 | DebrecenDebrecen |
| 14 Jul 22 | r03 | Kisvárda FCKisvárda FC | 2 - 3 | DiosgyorDiosgyor |
| 14 Jul 22 | r03 | Al-Duhail SCAl-Duhail SC | 1 - 0 | PanathinaikosPanathinaikos |
| 14 Jul 22 | r03 | BastiaBastia | 0 - 2 | Rodez AFRodez AF |
| 14 Jul 22 | r03 | SC Dnipro-1SC Dnipro-1 | 2 - 4 | Aris LimassolAris Limassol |
| 14 Jul 22 | r03 | ArisAris | 2 - 0 | IonikosIonikos |
| 14 Jul 22 | r03 | Sporting CPSporting CP | 1 - 1 | VillarrealVillarreal |
| 15 Jul 22 | r03 | LucerneLucerne | 2 - 0 | GenoaGenoa |
| 15 Jul 22 | r03 | Beitar JerusalemBeitar Jerusa | 2 - 0 | Maccabi Kabilio JaffaMaccabi Kabil |
| 15 Jul 22 | r03 | VizelaVizela | 1 - 3 | TorreenseTorreense |
| 15 Jul 22 | r03 | Mlada BoleslavMlada Bolesla | - | VarnsdorfVarnsdorf |
| 15 Jul 22 | r03 | Bohemians 1905Bohemians 190 | - | FC LieferingFC Liefering |
| 15 Jul 22 | r03 | FC LieferingFC Liefering | 0 - 2 | Bohemians 1905Bohemians 190 |
| 15 Jul 22 | r03 | Willem IIWillem II | 1 - 2 | De GraafschapDe Graafschap |
| 15 Jul 22 | r03 | FredericiaFredericia | 3 - 2 | Vendsyssel FFVendsyssel FF |
| 15 Jul 22 | r03 | Ein FrankfurtEin Frankfurt | 3 - 1 | TorinoTorino |
| 15 Jul 22 | r03 | Munich 1860Munich 1860 | 0 - 3 | NewcastleNewcastle |
| 15 Jul 22 | r03 | IngolstadtIngolstadt | 2 - 2 | SSV UlmSSV Ulm |
| 15 Jul 22 | r03 | SpartaSparta | 1 - 0 | SC Heracles AlmeloSC Heracles A |
| 15 Jul 22 | r03 | PEC ZwollePEC Zwolle | 0 - 2 | SC HeerenveenSC Heerenveen |
| 15 Jul 22 | r03 | Union BerlinUnion Berlin | - | Dynamo České BudějoviceDynamo České |
| 15 Jul 22 | r03 | GrenobleGrenoble | 1 - 1 | St EtienneSt Etienne |
| 15 Jul 22 | r03 | ZFC MeuselwitzZFC Meuselwit | 1 - 1 | Barockstadt Fulda-LehnerzBarockstadt F |
| 15 Jul 22 | r03 | KarmiotissaKarmiotissa | 0 - 1 | Banik OstravaBanik Ostrava |
| 15 Jul 22 | r03 | Fortuna KölnFortuna Köln | 1 - 1 | Roda JCRoda JC |
| 15 Jul 22 | r03 | BournemouthBournemouth | 2 - 1 | Sheffield WedsSheffield Wed |
| 15 Jul 22 | r03 | Chemnitzer FCChemnitzer FC | 2 - 2 | PribramPribram |
| 15 Jul 22 | r03 | NAC BredaNAC Breda | 0 - 0 | FC VolendamFC Volendam |
| 15 Jul 22 | r03 | KFC Uerdingen 05KFC Uerdingen | 3 - 2 | Bergisch Gladbach 09Bergisch Glad |
| 15 Jul 22 | r03 | Hannover IIHannover II | 2 - 2 | Chemie LeipzigChemie Leipzi |
| 15 Jul 22 | r03 | Pau FCPau FC | 1 - 0 | AngoulêmeAngoulême |
| 15 Jul 22 | r03 | StraelenStraelen | 0 - 1 | VVV-VenloVVV-Venlo |
| 15 Jul 22 | r03 | Lippstadt 08Lippstadt 08 | - | KSV BaunatalKSV Baunatal |
| 15 Jul 22 | r03 | BragaBraga | - | MiddlesbroughMiddlesbrough |
| 15 Jul 22 | r03 | ShrewsburyShrewsbury | 1 - 3 | BurnleyBurnley |
| 15 Jul 22 | r03 | AntwerpAntwerp | 2 - 1 | Dynamo KievDynamo Kiev |
| 15 Jul 22 | r03 | StockportStockport | - | ChorleyChorley |
| 15 Jul 22 | r03 | Weston-super-Mare FCWeston-super- | - | NewportNewport |
| 15 Jul 22 | r03 | MillwallMillwall | - | ColchesterColchester |
| 15 Jul 22 | r03 | ChorleyChorley | 0 - 5 | StockportStockport |
| 15 Jul 22 | r03 | BenficaBenfica | 3 - 0 | NiceNice |
| 16 Jul 22 | r03 | Weiche Flensburg 08Weiche Flensb | - | FredericiaFredericia |
| 16 Jul 22 | r03 | SpVgg BayreuthSpVgg Bayreut | - | PribramPribram |
| 16 Jul 22 | r03 | Szeged-CsanádSzeged-Csanád | 0 - 2 | VeneziaVenezia |
| 16 Jul 22 | r03 | Estrela AmadoraEstrela Amado | 1 - 0 | TrofenseTrofense |
| 16 Jul 22 | r03 | ZlínZlín | - | LíšeňLíšeň |
| 16 Jul 22 | r03 | CD Nacional de MadeiraCD Nacional d | 0 - 1 | MaritimoMaritimo |
| 16 Jul 22 | r03 | Hradec KrálovéHradec Králov | 1 - 0 | Vysočina JihlavaVysočina Jihl |
| 16 Jul 22 | r03 | KarvinaKarvina | 2 - 1 | Sigma Olomouc BSigma Olomouc |
| 16 Jul 22 | r03 | Rodez AFRodez AF | 0 - 1 | LensLens |
| 16 Jul 22 | r03 | VlašimVlašim | - | Viktoria ŽižkovViktoria Žižk |
| 16 Jul 22 | r03 | GyorGyor | 3 - 1 | Rapid Wien IIRapid Wien II |
| 16 Jul 22 | r03 | WesterloWesterlo | 2 - 3 | Beerschot VABeerschot VA |
| 16 Jul 22 | r03 | Kolding IFKolding IF | - | Young Boys FDYoung Boys FD |
| 16 Jul 22 | r03 | PenafielPenafiel | 0 - 0 | Santa ClaraSanta Clara |
| 16 Jul 22 | r03 | SC FarenseSC Farense | 2 - 1 | Associação Académica de CAssociação Ac |
| 16 Jul 22 | r03 | Estoril-PraiaEstoril-Praia | 1 - 0 | MafraMafra |
| 16 Jul 22 | r03 | Braga BBraga B | 1 - 2 | ChavesChaves |
| 16 Jul 22 | r03 | Rio AveRio Ave | 0 - 0 | F.C. Paços de FerreiraF.C. Paços de |
| 16 Jul 22 | r03 | FC HelsingoerFC Helsingoer | 2 - 0 | AB GladsaxeAB Gladsaxe |
| 16 Jul 22 | r03 | Dortmund IIDortmund II | 1 - 1 | RKC WaalwijkRKC Waalwijk |
| 16 Jul 22 | r03 | MechelenMechelen | - | Fortuna SittardFortuna Sitta |
| 16 Jul 22 | r03 | VfV HildesheimVfV Hildeshei | 2 - 2 | Germania HalberstadtGermania Halb |
| 16 Jul 22 | r03 | HerthaHertha | - | HalifaxHalifax |
| 16 Jul 22 | r03 | WatfordWatford | 4 - 1 | WycombeWycombe |
| 16 Jul 22 | r03 | BrønshøjBrønshøj | 2 - 4 | Hvidovre IFHvidovre IF |
| 16 Jul 22 | r03 | Stade NyonnaisStade Nyonnai | 1 - 4 | SochauxSochaux |
| 16 Jul 22 | r03 | Hertha IIHertha II | 3 - 1 | Tasmania BerlinTasmania Berl |
| 16 Jul 22 | r03 | FC PortoFC Porto | 2 - 1 | GuimaraesGuimaraes |
| 16 Jul 22 | r03 | Crystal PalaceCrystal Palac | 4 - 2 | IpswichIpswich |
| 16 Jul 22 | r03 | Skive IKSkive IK | - | VSK ÅrhusVSK Århus |
| 16 Jul 22 | r03 | UxbridgeUxbridge | - | Maidenhead UnitedMaidenhead Un |
| 16 Jul 22 | r03 | Harrogate Town FCHarrogate Tow | - | Huddersfield TownHuddersfield |
| 16 Jul 22 | r03 | HillerødHillerød | 1 - 0 | RoskildeRoskilde |
| 16 Jul 22 | r03 | KøgeKøge | 1 - 2 | Næstved BKNæstved BK |
| 16 Jul 22 | r03 | OsnabrueckOsnabrueck | - | FC GroningenFC Groningen |
| 16 Jul 22 | r03 | Lichtenberg 47Lichtenberg 4 | 1 - 0 | Berliner FC DynamoBerliner FC D |
| 16 Jul 22 | r03 | TuS DassendorfTuS Dassendor | 0 - 1 | Teutonia OttensenTeutonia Otte |
| 16 Jul 22 | r03 | CelticCeltic | 2 - 2 | BlackburnBlackburn |
| 16 Jul 22 | r03 | ScunthorpeScunthorpe | 3 - 2 | Sheffield UnitedSheffield Uni |
| 16 Jul 22 | r03 | Hallescher FCHallescher FC | - | QPRQPR |
| 16 Jul 22 | r03 | Slough TownSlough Town | - | AldershotAldershot |
| 16 Jul 22 | r03 | TOP OssTOP Oss | - | FC DordrechtFC Dordrecht |
| 16 Jul 22 | r03 | Oud-Heverlee LeuvenOud-Heverlee | - | LeicesterLeicester |
| 16 Jul 22 | r03 | StandardStandard | - | MönchengladbachMönchengladba |
| 16 Jul 22 | r03 | NorthamptonNorthampton | - | LutonLuton |
| 16 Jul 22 | r03 | OldhamOldham | - | WiganWigan |
| 16 Jul 22 | r03 | FC SaarbrückenFC Saarbrücke | 4 - 2 | FC Koln IIFC Koln II |
| 16 Jul 22 | r03 | Cambridge UnitedCambridge Uni | - | Notts CountyNotts County |
| 16 Jul 22 | r03 | TSV Steinbach HaigerTSV Steinbach | - | Rot-Weiß OberhausenRot-Weiß Ober |
| 16 Jul 22 | r03 | AachenAachen | - | Rot-Weiss EssenRot-Weiss Ess |
| 16 Jul 22 | r03 | StokeStoke | 1 - 1 | Fleetwood TownFleetwood Tow |
| 16 Jul 22 | r03 | FC DordrechtFC Dordrecht | - | TOP OssTOP Oss |
| 16 Jul 22 | r03 | Swindon SupermarineSwindon Super | 1 - 2 | Forest Green RoversForest Green |
| 16 Jul 22 | r03 | Union FürstenwaldeUnion Fürsten | 1 - 4 | SV BabelsbergSV Babelsberg |
| 16 Jul 22 | r03 | Hessen KasselHessen Kassel | 5 - 1 | Wuppertaler SVWuppertaler S |
| 16 Jul 22 | r03 | ADO Den HaagADO Den Haag | - | KMSK DeinzeKMSK Deinze |
| 16 Jul 22 | r03 | SC VerlSC Verl | - | SønderjyskeSønderjyske |
| 16 Jul 22 | r03 | FC Den BoschFC Den Bosch | 4 - 0 | Amsterdamsche FCAmsterdamsche |
| 16 Jul 22 | r03 | Freiburg IIFreiburg II | 1 - 1 | Hoffenheim IIHoffenheim II |
| 16 Jul 22 | r03 | Schalke 04 IISchalke 04 II | - | Rot-Weiß KoblenzRot-Weiß Kobl |
| 16 Jul 22 | r03 | SwanseaSwansea | - | Bristol RoversBristol Rover |
| 16 Jul 22 | r03 | Almere City FCAlmere City F | 1 - 3 | KMSK DeinzeKMSK Deinze |
| 16 Jul 22 | r03 | Werder Bremen IIWerder Bremen | 4 - 3 | Fortuna Düsseldorf IIFortuna Düsse |
| 16 Jul 22 | r03 | RasenBallsport LeipzigRasenBallspor | 3 - 1 | SouthamptonSouthampton |
| 16 Jul 22 | r03 | Bahlinger SCBahlinger SC | 0 - 2 | Mainz IIMainz II |
| 16 Jul 22 | r03 | NEC NijmegenNEC Nijmegen | 4 - 0 | BocholtBocholt |
| 16 Jul 22 | r03 | HeartsHearts | 2 - 2 | CrawleyCrawley |
| 16 Jul 22 | r03 | SpVgg BayreuthSpVgg Bayreut | 1 - 1 | CottbusCottbus |
| 16 Jul 22 | r03 | Lippstadt 08Lippstadt 08 | 1 - 3 | SønderjyskeSønderjyske |
| 16 Jul 22 | r03 | Koninklijke HFCKoninklijke H | 0 - 3 | Jong AZJong AZ |
| 16 Jul 22 | r03 | Werder BremenWerder Bremen | - | FC TwenteFC Twente |
| 16 Jul 22 | r03 | South ShieldsSouth Shields | 1 - 2 | BarrowBarrow |
| 16 Jul 22 | r03 | BurtonBurton | 1 - 2 | BirminghamBirmingham |
| 16 Jul 22 | r03 | Tennis Borussia BerlinTennis Boruss | - | Kickers EmdenKickers Emden |
| 16 Jul 22 | r03 | SSV JeddelohSSV Jeddeloh | - | OldenburgOldenburg |
| 16 Jul 22 | r03 | Dynamo DresdenDynamo Dresde | - | TepliceTeplice |
| 16 Jul 22 | r03 | H and W WeldersH and W Welde | - | LinfieldLinfield |
| 16 Jul 22 | r03 | LoughgallLoughgall | - | GlenavonGlenavon |
| 16 Jul 22 | r03 | St Albans CitySt Albans Cit | - | StevenageStevenage |
| 16 Jul 22 | r03 | AccringtonAccrington | - | PrestonPreston |
| 16 Jul 22 | r03 | YorkYork | - | BradfordBradford |
| 16 Jul 22 | r03 | SalernitanaSalernitana | - | HoffenheimHoffenheim |
| 16 Jul 22 | r03 | FreiburgFreiburg | 3 - 0 | VallecanoVallecano |
| 16 Jul 22 | r03 | Limavady UnitedLimavady Unit | 0 - 1 | Carrick RangersCarrick Range |
| 16 Jul 22 | r03 | Hamburg IIHamburg II | 11 - 0 | Lüneburger SK HansaLüneburger SK |
| 16 Jul 22 | r03 | Paksi FCPaksi FC | 3 - 2 | Sigma OlomoucSigma Olomouc |
| 16 Jul 22 | r03 | Carl Zeiss JenaCarl Zeiss Je | 2 - 2 | ZwickauZwickau |
| 16 Jul 22 | r03 | Mgladbach IIMgladbach II | 5 - 2 | St Pauli IISt Pauli II |
| 16 Jul 22 | r03 | GenkGenk | 0 - 2 | AEKAEK |
| 16 Jul 22 | r03 | LiberecLiberec | 0 - 0 | Újpest FCÚjpest FC |
| 16 Jul 22 | r03 | UdineseUdinese | 3 - 3 | Union BerlinUnion Berlin |
| 16 Jul 22 | r03 | Sturm Graz IISturm Graz II | 1 - 0 | DebrecenDebrecen |
| 16 Jul 22 | r03 | AFC WimbledonAFC Wimbledon | 0 - 3 | IpswichIpswich |
| 16 Jul 22 | r03 | StuttgartStuttgart | - | BrentfordBrentford |
| 16 Jul 22 | r03 | TSG BalingenTSG Balingen | 2 - 2 | SSV UlmSSV Ulm |
| 16 Jul 22 | r03 | Kettering TownKettering Tow | 2 - 2 | SouthendSouthend |
| 16 Jul 22 | r03 | YeovilYeovil | - | ExeterExeter |
| 16 Jul 22 | r03 | StockportStockport | - | CurzonCurzon |
| 16 Jul 22 | r03 | GillinghamGillingham | - | PortsmouthPortsmouth |
| 16 Jul 22 | r03 | PlymouthPlymouth | - | Bristol CityBristol City |
| 16 Jul 22 | r03 | CarlisleCarlisle | - | BoltonBolton |
| 16 Jul 22 | r03 | TorquayTorquay | - | NewportNewport |
| 16 Jul 22 | r03 | Barry Town UnitedBarry Town Un | - | Dorking WanderersDorking Wande |
| 16 Jul 22 | r03 | CheltenhamCheltenham | 1 - 2 | CardiffCardiff |
| 16 Jul 22 | r03 | Oxford UtdOxford Utd | - | CoventryCoventry |
| 16 Jul 22 | r03 | HartlepoolHartlepool | - | LincolnLincoln |
| 16 Jul 22 | r03 | FarnboroughFarnborough | - | WokingWoking |
| 16 Jul 22 | r03 | CreweCrewe | - | West BromWest Brom |
| 16 Jul 22 | r03 | Sutton UnitedSutton United | - | CharltonCharlton |
| 16 Jul 22 | r03 | EastleighEastleigh | - | SwindonSwindon |
| 16 Jul 22 | r03 | Darlington F.C.Darlington F. | - | RochdaleRochdale |
| 16 Jul 22 | r03 | Chester CityChester City | - | MorecambeMorecambe |
| 16 Jul 22 | r03 | MansfieldMansfield | - | RotherhamRotherham |
| 16 Jul 22 | r03 | Dundee UnitedDundee United | - | SunderlandSunderland |
| 16 Jul 22 | r03 | Helmond SportHelmond Sport | - | Go Ahead EaglesGo Ahead Eagl |
| 16 Jul 22 | r03 | ReadingReading | - | West HamWest Ham |
| 16 Jul 22 | r03 | Spennymoor Town FCSpennymoor To | - | Gateshead FCGateshead FC |
| 16 Jul 22 | r03 | Kings Lynn TownKings Lynn To | - | Milton Keynes DonsMilton Keynes |
| 16 Jul 22 | r03 | MatlockMatlock | - | ChesterfieldChesterfield |
| 16 Jul 22 | r03 | Annagh UnitedAnnagh United | - | GlentoranGlentoran |
| 16 Jul 22 | r03 | DoncasterDoncaster | - | Huddersfield TownHuddersfield |
| 16 Jul 22 | r03 | WaregemWaregem | - | ValenciennesValenciennes |
| 16 Jul 22 | r03 | Alfreton TownAlfreton Town | 0 - 4 | GrimsbyGrimsby |
| 16 Jul 22 | r03 | ColeraineColeraine | 4 - 0 | Ballyclare ComradesBallyclare Co |
| 16 Jul 22 | r03 | Armagh CityArmagh City | - | Newry City AFCNewry City AF |
| 16 Jul 22 | r03 | SO CholetSO Cholet | 1 - 3 | AjaccioAjaccio |
| 16 Jul 22 | r03 | SouthportSouthport | 1 - 4 | TranmereTranmere |
| 16 Jul 22 | r03 | BlackpoolBlackpool | 1 - 2 | RangersRangers |
| 16 Jul 22 | r03 | WesterloWesterlo | 0 - 1 | AZ AlkmaarAZ Alkmaar |
| 16 Jul 22 | r03 | Nantwich TownNantwich Town | 2 - 5 | WrexhamWrexham |
| 16 Jul 22 | r03 | MechelenMechelen | 3 - 4 | WolfsburgWolfsburg |
| 16 Jul 22 | r03 | BromleyBromley | 0 - 0 | DartfordDartford |
| 16 Jul 22 | r03 | KortrijkKortrijk | 2 - 1 | FC UtrechtFC Utrecht |
| 16 Jul 22 | r03 | MaidstoneMaidstone | 6 - 1 | Enfield TownEnfield Town |
| 16 Jul 22 | r03 | Clermont FootClermont Foot | 1 - 3 | LensLens |
| 16 Jul 22 | r03 | DergviewDergview | 1 - 2 | Dungannon SwiftsDungannon Swi |
| 16 Jul 22 | r03 | DenderDender | 0 - 5 | Cercle BruggeCercle Brugge |
| 16 Jul 22 | r03 | SpeziaSpezia | 1 - 2 | BochumBochum |
| 16 Jul 22 | r03 | MetzMetz | 4 - 0 | TroyesTroyes |
| 16 Jul 22 | r03 | PardubicePardubice | 0 - 0 | Dukla PrahaDukla Praha |
| 16 Jul 22 | r03 | SampdoriaSampdoria | 1 - 1 | Parma Calcio 1913Parma Calcio |
| 16 Jul 22 | r03 | SC CambuurSC Cambuur | 2 - 1 | SC TelstarSC Telstar |
| 16 Jul 22 | r03 | DerbyDerby | 1 - 0 | HerthaHertha |
| 16 Jul 22 | r03 | VeronaVerona | 1 - 0 | Virtus VeronaVirtus Verona |
| 16 Jul 22 | r03 | SassuoloSassuolo | 3 - 1 | JablonecJablonec |
| 16 Jul 22 | r03 | CaenCaen | 0 - 2 | NantesNantes |
| 16 Jul 22 | r03 | BrestBrest | 1 - 0 | LorientLorient |
| 16 Jul 22 | r03 | Le HavreLe Havre | 1 - 4 | AmiensAmiens |
| 16 Jul 22 | r03 | BastiaBastia | 0 - 1 | NimesNimes |
| 16 Jul 22 | r03 | FreiburgFreiburg | 1 - 0 | RennesRennes |
| 16 Jul 22 | r03 | TondelaTondela | 1 - 1 | Santa ClaraSanta Clara |
| 16 Jul 22 | r03 | AuxerreAuxerre | 0 - 2 | Stade de ReimsStade de Reim |
| 16 Jul 22 | r03 | Sturm Graz IISturm Graz II | - | Austria Vienna (Am)Austria Vienn |
| 16 Jul 22 | r03 | DebrecenDebrecen | 1 - 0 | KazincbarcikaKazincbarcika |
| 16 Jul 22 | r03 | MarseilleMarseille | 0 - 3 | NorwichNorwich |
| 16 Jul 22 | r03 | SC FarenseSC Farense | 3 - 2 | AnadiaAnadia |
| 16 Jul 22 | r03 | EspanolEspanol | 2 - 0 | MontpellierMontpellier |
| 16 Jul 22 | r03 | BarnsleyBarnsley | 0 - 0 | Nottingham ForestNottingham Fo |
| 16 Jul 22 | r03 | CottbusCottbus | - | Vendsyssel FFVendsyssel FF |
| 16 Jul 22 | r03 | HullHull | 3 - 1 | MalagaMalaga |
| 16 Jul 22 | r03 | ExcelsiorExcelsior | - | FC DordrechtFC Dordrecht |
| 16 Jul 22 | r03 | Lierse KempenzonenLierse Kempen | - | FC EindhovenFC Eindhoven |
| 16 Jul 22 | r03 | ConcarneauConcarneau | 1 - 0 | GuingampGuingamp |
| 16 Jul 22 | r03 | CaenCaen | - | BordeauxBordeaux |
| 16 Jul 22 | r03 | LugoLugo | 0 - 2 | PonferradinaPonferradina |
| 16 Jul 22 | r03 | BurgosBurgos | 1 - 1 | AlavesAlaves |
| 16 Jul 22 | r03 | CharleroiCharleroi | 1 - 2 | StrasbourgStrasbourg |
| 16 Jul 22 | r03 | Estoril-PraiaEstoril-Praia | 1 - 4 | BrightonBrighton |
| 16 Jul 22 | r03 | CalahorraCalahorra | 0 - 2 | EibarEibar |
| 16 Jul 22 | r03 | AnderlechtAnderlecht | 2 - 3 | LyonLyon |
| 16 Jul 22 | r03 | Benfica BBenfica B | 0 - 1 | MafraMafra |
| 16 Jul 22 | r03 | FulhamFulham | 0 - 2 | NiceNice |
| 16 Jul 22 | r03 | YeclanoYeclano | 2 - 3 | Cartagena FCCartagena FC |
| 17 Jul 22 | r03 | Kryvbas Kryvyi RihKryvbas Kryvy | 0 - 1 | InhuletsInhulets |
| 17 Jul 22 | r03 | Korona KielceKorona Kielce | 1 - 4 | ZoryaZorya |
| 17 Jul 22 | r03 | VojvodinaVojvodina | 5 - 1 | Bačka PalankaBačka Palanka |
| 17 Jul 22 | r03 | Vejle BoldklubVejle Boldklu | 0 - 0 | Aarhus FremadAarhus Fremad |
| 17 Jul 22 | r03 | HOBROHOBRO | 3 - 0 | ThistedThisted |
| 17 Jul 22 | r03 | Lichtenberg 47Lichtenberg 4 | - | Berliner FC DynamoBerliner FC D |
| 17 Jul 22 | r03 | GenkGenk | 4 - 0 | RFC SeraingRFC Seraing |
| 17 Jul 22 | r03 | Rot-Weiß ErfurtRot-Weiß Erfu | 3 - 4 | Hallescher FCHallescher FC |
| 17 Jul 22 | r03 | Wuppertaler SVWuppertaler S | 2 - 2 | Jong UtrechtJong Utrecht |
| 17 Jul 22 | r03 | KV OostendeKV Oostende | 2 - 0 | VitesseVitesse |
| 17 Jul 22 | r03 | Wehen WiesbadenWehen Wiesbad | 2 - 3 | GrasshoppersGrasshoppers |
| 17 Jul 22 | r03 | Kickers OffenbachKickers Offen | - | FC KolnFC Koln |
| 17 Jul 22 | r03 | Schwarz-Weiß RehdenSchwarz-Weiß | - | RödinghausenRödinghausen |
| 17 Jul 22 | r03 | AugsburgAugsburg | - | Al-Duhail SCAl-Duhail SC |
| 17 Jul 22 | r03 | Holstein Kiel IIHolstein Kiel | 2 - 1 | Drochtersen-AsselDrochtersen-A |
| 17 Jul 22 | r03 | UdineseUdinese | - | Schalke 04Schalke 04 |
| 17 Jul 22 | r03 | AugsburgAugsburg | 1 - 1 | Schalke 04Schalke 04 |
| 17 Jul 22 | r03 | Mezőkövesdi SEMezőkövesdi S | 3 - 3 | Apollon LimassolApollon Limas |
| 17 Jul 22 | r03 | LeverkusenLeverkusen | 0 - 0 | PanathinaikosPanathinaikos |
| 17 Jul 22 | r03 | WSG Swarovski TirolWSG Swarovski | 0 - 4 | Al-Duhail SCAl-Duhail SC |
| 17 Jul 22 | r03 | UdineseUdinese | 3 - 0 | IlirijaIlirija |
| 17 Jul 22 | r03 | LazioLazio | 3 - 1 | TriestinaTriestina |
| 17 Jul 22 | r03 | AngersAngers | 0 - 0 | LavalLaval |
| 17 Jul 22 | r03 | NFC VolosNFC Volos | 2 - 1 | IonikosIonikos |
| 17 Jul 22 | r03 | NapoliNapoli | 4 - 1 | PerugiaPerugia |
| 17 Jul 22 | r03 | CremoneseCremonese | 5 - 0 | U.S. Fiorenzuola 1922 S.SU.S. Fiorenzu |
| 17 Jul 22 | r03 | MTK HungariaMTK Hungaria | 2 - 4 | FC AshdodFC Ashdod |
| 17 Jul 22 | r03 | FC GroningenFC Groningen | - | FC EmmenFC Emmen |
| 17 Jul 22 | r03 | AlmeriaAlmeria | 1 - 0 | VélezVélez |
| 17 Jul 22 | r03 | BenficaBenfica | 5 - 1 | FulhamFulham |
| 18 Jul 22 | r03 | FC CopenhagenFC Copenhagen | 2 - 1 | Fremad AmagerFremad Amager |
| 18 Jul 22 | r03 | NykøbingNykøbing | 0 - 0 | B.93B.93 |
| 18 Jul 22 | r03 | MainzMainz | 1 - 0 | NewcastleNewcastle |
| 18 Jul 22 | r03 | SAK KlagenfurtSAK Klagenfur | 0 - 0 | SouthamptonSouthampton |
| 18 Jul 22 | r03 | Omonia NicosiaOmonia Nicosi | 0 - 1 | Hapoel HaifaHapoel Haifa |
| 18 Jul 22 | r03 | Ballymacash RangersBallymacash R | 0 - 2 | Carrick RangersCarrick Range |
| 19 Jul 22 | r03 | Huddersfield TownHuddersfield | - | LutonLuton |
| 19 Jul 22 | r03 | JammerbugtJammerbugt | 0 - 2 | EsbjergEsbjerg |
| 19 Jul 22 | r03 | De TreffersDe Treffers | - | NEC NijmegenNEC Nijmegen |
| 19 Jul 22 | r03 | EsbjergEsbjerg | - | Kolding IFKolding IF |
| 19 Jul 22 | r03 | SalernitanaSalernitana | - | VallecanoVallecano |
| 19 Jul 22 | r03 | BrentfordBrentford | 2 - 2 | StrasbourgStrasbourg |
| 19 Jul 22 | r03 | Bristol CityBristol City | 3 - 1 | Forest Green RoversForest Green |
| 19 Jul 22 | r03 | VSG AltglienickeVSG Altglieni | 2 - 1 | Teutonia OttensenTeutonia Otte |
| 19 Jul 22 | r03 | Bristol CityBristol City | 2 - 2 | ExeterExeter |
| 19 Jul 22 | r03 | Mezőkövesdi SEMezőkövesdi S | 2 - 1 | LiberecLiberec |
| 19 Jul 22 | r03 | GianninaGiannina | 1 - 1 | Banik OstravaBanik Ostrava |
| 19 Jul 22 | r03 | EmpoliEmpoli | 3 - 0 | Seravezza Pozzi CalcioSeravezza Poz |
| 19 Jul 22 | r03 | TorinoTorino | 2 - 0 | Mlada BoleslavMlada Bolesla |
| 19 Jul 22 | r03 | OsasunaOsasuna | 3 - 3 | ToulouseToulouse |
| 19 Jul 22 | r03 | AccringtonAccrington | 0 - 0 | WiganWigan |
| 19 Jul 22 | r03 | BastiaBastia | 0 - 2 | AS Furiani-AglianiAS Furiani-Ag |
| 19 Jul 22 | r03 | Hannoverscher SCHannoverscher | 0 - 6 | Hannover IIHannover II |
| 19 Jul 22 | r03 | BragaBraga | 2 - 1 | BournemouthBournemouth |
| 19 Jul 22 | r03 | VVV-VenloVVV-Venlo | 2 - 3 | Jong AZJong AZ |
| 19 Jul 22 | r03 | De GraafschapDe Graafschap | 3 - 2 | FC EmmenFC Emmen |
| 19 Jul 22 | r03 | ASM BelfortASM Belfort | 1 - 2 | SochauxSochaux |
| 19 Jul 22 | r03 | Leyton OrientLeyton Orient | 2 - 5 | PortsmouthPortsmouth |
| 19 Jul 22 | r03 | MorecambeMorecambe | 0 - 3 | MiddlesbroughMiddlesbrough |
| 19 Jul 22 | r03 | DoncasterDoncaster | 2 - 2 | RotherhamRotherham |
| 19 Jul 22 | r03 | BradfordBradford | 2 - 0 | SunderlandSunderland |
| 19 Jul 22 | r03 | Sheffield UnitedSheffield Uni | 0 - 3 | MansfieldMansfield |
| 19 Jul 22 | r03 | GillinghamGillingham | 2 - 3 | Crystal PalaceCrystal Palac |
| 19 Jul 22 | r03 | BangorBangor | 3 - 7 | GlenavonGlenavon |
| 19 Jul 22 | r03 | Hebburn TownHebburn Town | 1 - 0 | Gateshead FCGateshead FC |
| 19 Jul 22 | r03 | Bamber BridgeBamber Bridge | - | BoltonBolton |
| 19 Jul 22 | r03 | ColchesterColchester | - | SouthendSouthend |
| 19 Jul 22 | r03 | ScunthorpeScunthorpe | - | RochdaleRochdale |
| 19 Jul 22 | r03 | WalsallWalsall | - | CoventryCoventry |
| 19 Jul 22 | r03 | Hitchin TownHitchin Town | - | Boreham WoodBoreham Wood |
| 19 Jul 22 | r03 | GrimsbyGrimsby | - | LincolnLincoln |
| 19 Jul 22 | r03 | DundelaDundela | - | Ballymena UnitedBallymena Uni |
| 19 Jul 22 | r03 | ChesterfieldChesterfield | - | Alfreton TownAlfreton Town |
| 19 Jul 22 | r03 | StevenageStevenage | 1 - 0 | DerbyDerby |
| 19 Jul 22 | r03 | Darlington F.C.Darlington F. | - | Gateshead FCGateshead FC |
| 19 Jul 22 | r03 | KnockbredaKnockbreda | 1 - 2 | Ballymena UnitedBallymena Uni |
| 19 Jul 22 | r03 | AFC Rushden and DiamondsAFC Rushden a | - | NorthamptonNorthampton |
| 19 Jul 22 | r03 | Brackley TownBrackley Town | 2 - 1 | BurtonBurton |
| 19 Jul 22 | r03 | Bristol RoversBristol Rover | 2 - 0 | StokeStoke |
| 19 Jul 22 | r03 | Bishops StortfordBishops Stort | 0 - 3 | Dagenham & Red.Dagenham & Re |
| 19 Jul 22 | r03 | TorquayTorquay | 0 - 5 | PlymouthPlymouth |
| 19 Jul 22 | r03 | MaidstoneMaidstone | - | Tonbridge AngelsTonbridge Ang |
| 19 Jul 22 | r03 | Oxford UtdOxford Utd | 0 - 3 | West BromWest Brom |
| 19 Jul 22 | r03 | Sutton UnitedSutton United | 0 - 1 | WokingWoking |
| 19 Jul 22 | r03 | CurzonCurzon | - | AltrinchamAltrincham |
| 19 Jul 22 | r03 | AFC WimbledonAFC Wimbledon | 0 - 2 | ReadingReading |
| 19 Jul 22 | r03 | CheltenhamCheltenham | 1 - 0 | BirminghamBirmingham |
| 19 Jul 22 | r03 | DartfordDartford | 2 - 0 | BarnetBarnet |
| 19 Jul 22 | r03 | BarrowBarrow | - | Fleetwood TownFleetwood Tow |
| 19 Jul 22 | r03 | AFC Rushden & DiamondsAFC Rushden & | - | NorthamptonNorthampton |
| 19 Jul 22 | r03 | Bradford Park AvenueBradford Park | 2 - 0 | OldhamOldham |
| 19 Jul 22 | r03 | WealdstoneWealdstone | - | QPRQPR |
| 19 Jul 22 | r03 | ColeraineColeraine | 1 - 2 | InstituteInstitute |
| 19 Jul 22 | r03 | RangersRangers | 3 - 1 | West HamWest Ham |
| 19 Jul 22 | r03 | MillwallMillwall | - | WatfordWatford |
| 19 Jul 22 | r03 | LoughgallLoughgall | 2 - 3 | Dungannon SwiftsDungannon Swi |
| 19 Jul 22 | r03 | Bishops StortfordBishops Stort | - | Dagenham and RedbridgeDagenham and |
| 19 Jul 22 | r03 | ShrewsburyShrewsbury | 0 - 0 | CardiffCardiff |
| 19 Jul 22 | r03 | FC Den BoschFC Den Bosch | 7 - 0 | VV UNAVV UNA |
| 19 Jul 22 | r03 | Cambridge UnitedCambridge Uni | 1 - 3 | NorwichNorwich |
| 19 Jul 22 | r03 | Salford CitySalford City | 0 - 1 | BlackpoolBlackpool |
| 20 Jul 22 | r03 | TroyesTroyes | 3 - 0 | Le HavreLe Havre |
| 20 Jul 22 | r03 | CreweCrewe | 3 - 1 | Lommel SKLommel SK |
| 20 Jul 22 | r03 | FC VillefrancheFC Villefranc | 2 - 0 | GrenobleGrenoble |
| 20 Jul 22 | r03 | NiortNiort | - | LavalLaval |
| 20 Jul 22 | r03 | NFC VolosNFC Volos | 0 - 2 | AtromitosAtromitos |
| 20 Jul 22 | r03 | NiceNice | - | BragaBraga |
| 20 Jul 22 | r03 | DiosgyorDiosgyor | - | DebrecenDebrecen |
| 20 Jul 22 | r03 | Sporting CPSporting CP | 0 - 2 | PortimonensePortimonense |
| 20 Jul 22 | r03 | LavalLaval | 3 - 1 | US Lusitanos Saint-MaurUS Lusitanos |
| 20 Jul 22 | r03 | Viktoria ŽižkovViktoria Žižk | 2 - 2 | Slavia Prague BSlavia Prague |
| 20 Jul 22 | r03 | AroucaArouca | 1 - 0 | FeirenseFeirense |
| 20 Jul 22 | r03 | MaritimoMaritimo | 1 - 1 | PenafielPenafiel |
| 20 Jul 22 | r03 | Gil VicenteGil Vicente | - | Santa ClaraSanta Clara |
| 20 Jul 22 | r03 | Academico ViseuAcademico Vis | 0 - 2 | São João de VerSão João de V |
| 20 Jul 22 | r03 | MafraMafra | 0 - 1 | Casa PiaCasa Pia |
| 20 Jul 22 | r03 | Willem IIWillem II | 0 - 2 | SpartaSparta |
| 20 Jul 22 | r03 | Stade de ReimsStade de Reim | 1 - 0 | MetzMetz |
| 20 Jul 22 | r03 | LübeckLübeck | 4 - 4 | Berliner AK 07Berliner AK 0 |
| 20 Jul 22 | r03 | AtalantaAtalanta | - | LeccoLecco |
| 20 Jul 22 | r03 | AngersAngers | 0 - 2 | BrestBrest |
| 20 Jul 22 | r03 | MonzaMonza | 4 - 1 | PiacenzaPiacenza |
| 20 Jul 22 | r03 | SPAL 2013SPAL 2013 | 3 - 1 | Virtus VeronaVirtus Verona |
| 20 Jul 22 | r03 | Legia WarsawLegia Warsaw | 2 - 2 | CelticCeltic |
| 20 Jul 22 | r03 | FC UtrechtFC Utrecht | 4 - 0 | OFIOFI |
| 20 Jul 22 | r03 | St EtienneSt Etienne | 1 - 1 | BordeauxBordeaux |
| 20 Jul 22 | r03 | MönchengladbachMönchengladba | 1 - 1 | RKC WaalwijkRKC Waalwijk |
| 20 Jul 22 | r03 | SantanderSantander | 0 - 1 | Sp GijonSp Gijon |
| 20 Jul 22 | r03 | Athletic Bilbao BAthletic Bilb | 0 - 1 | EibarEibar |
| 20 Jul 22 | r03 | CaenCaen | 1 - 2 | RennesRennes |
| 20 Jul 22 | r03 | SSV JeddelohSSV Jeddeloh | 3 - 3 | Atlas DelmenhorstAtlas Delmenh |
| 20 Jul 22 | r03 | VVV-VenloVVV-Venlo | - | AZ AlkmaarAZ Alkmaar |
| 20 Jul 22 | r03 | WolvesWolves | 4 - 0 | AlavesAlaves |
| 20 Jul 22 | r03 | MontpellierMontpellier | 0 - 2 | Clermont FootClermont Foot |
| 20 Jul 22 | r03 | FC EilenburgFC Eilenburg | 2 - 3 | Lokomotive LeipzigLokomotive Le |
| 20 Jul 22 | r03 | Budafoki MTEBudafoki MTE | 0 - 3 | SlovackoSlovacko |
| 20 Jul 22 | r03 | Phönix LübeckPhönix Lübeck | 1 - 1 | TodesfeldeTodesfelde |
| 20 Jul 22 | r03 | ChavesChaves | 3 - 1 | Vitória de Guimarães BVitória de Gu |
| 20 Jul 22 | r03 | F.C. Paços de FerreiraF.C. Paços de | 1 - 0 | Santa ClaraSanta Clara |
| 20 Jul 22 | r03 | Estrela AmadoraEstrela Amado | - | MafraMafra |
| 20 Jul 22 | r03 | HuescaHuesca | 1 - 1 | Osasuna BOsasuna B |
| 20 Jul 22 | r03 | ElcheElche | 1 - 3 | Villarreal BVillarreal B |
| 20 Jul 22 | r03 | Racing Club de FerrolRacing Club d | 0 - 0 | Real OviedoReal Oviedo |
| 20 Jul 22 | r03 | St. GallenSt. Gallen | 0 - 2 | ValenciaValencia |
| 20 Jul 22 | r03 | Bahlinger SCBahlinger SC | 0 - 1 | FreiburgFreiburg |
| 20 Jul 22 | r03 | LugoLugo | 1 - 3 | BurgosBurgos |
| 20 Jul 22 | r03 | HartlepoolHartlepool | 0 - 1 | BlackburnBlackburn |
| 20 Jul 22 | r03 | Harrogate Town FCHarrogate Tow | 2 - 2 | BarnsleyBarnsley |
| 20 Jul 22 | r03 | SV SpakenburgSV Spakenburg | 2 - 2 | SC TelstarSC Telstar |
| 20 Jul 22 | r03 | Nottingham ForestNottingham Fo | 3 - 1 | HerthaHertha |
| 20 Jul 22 | r03 | Sheffield WedsSheffield Wed | 0 - 2 | VallecanoVallecano |
| 20 Jul 22 | r03 | MillwallMillwall | 0 - 0 | HammarbyHammarby |
| 20 Jul 22 | r03 | Kings Lynn TownKings Lynn To | 1 - 0 | PeterboroPeterboro |
| 20 Jul 22 | r03 | GuiseleyGuiseley | 1 - 0 | YorkYork |
| 20 Jul 22 | r03 | ArbroathArbroath | 1 - 2 | AFC FyldeAFC Fylde |
| 20 Jul 22 | r03 | Hitchin TownHitchin Town | 0 - 2 | Boreham WoodBoreham Wood |
| 20 Jul 22 | r03 | CordobaCordoba | 1 - 0 | GranadaGranada |
| 20 Jul 22 | r03 | HeartsHearts | 2 - 1 | PrestonPreston |
| 20 Jul 22 | r03 | Boston United FCBoston United | 1 - 1 | Notts CountyNotts County |
| 20 Jul 22 | r03 | PeterboroPeterboro | 0 - 2 | LutonLuton |
| 20 Jul 22 | r03 | Potters Bar TownPotters Bar T | 3 - 4 | Maidenhead UnitedMaidenhead Un |
| 20 Jul 22 | r03 | HullHull | 0 - 4 | LeicesterLeicester |
| 20 Jul 22 | r03 | WealdstoneWealdstone | 2 - 8 | QPRQPR |
| 21 Jul 22 | r03 | Minnesota UnitedMinnesota Uni | 4 - 0 | EvertonEverton |
| 21 Jul 22 | r03 | JablonecJablonec | 3 - 0 | SpeziaSpezia |
| 21 Jul 22 | r03 | SC Dnipro-1SC Dnipro-1 | 1 - 1 | Beitar JerusalemBeitar Jerusa |
| 21 Jul 22 | r03 | KarpatyKarpaty | 1 - 1 | Veres RivneVeres Rivne |
| 21 Jul 22 | r03 | MacclesfieldMacclesfield | - | Huddersfield TownHuddersfield |
| 21 Jul 22 | r03 | KrškoKrško | 0 - 4 | VeneziaVenezia |
| 21 Jul 22 | r03 | LazioLazio | 4 - 0 | PrimorjePrimorje |
| 21 Jul 22 | r03 | Annagh UnitedAnnagh United | 0 - 4 | LarneLarne |
| 21 Jul 22 | r03 | San Jose EarthquakesSan Jose Eart | 1 - 1 | Celta VigoCelta Vigo |
| 21 Jul 22 | r03 | LeganesLeganes | 2 - 0 | WrexhamWrexham |
| 21 Jul 22 | r03 | LevanteLevante | 2 - 1 | WolvesWolves |
| 21 Jul 22 | r03 | SassuoloSassuolo | 2 - 0 | SudtirolSudtirol |
| 21 Jul 22 | r03 | BochumBochum | 1 - 4 | Ath BilbaoAth Bilbao |
| 21 Jul 22 | r03 | UdineseUdinese | 1 - 2 | LeverkusenLeverkusen |
| 21 Jul 22 | r03 | PisaPisa | 5 - 0 | SSD PalermoSSD Palermo |
| 21 Jul 22 | r03 | GetafeGetafe | 1 - 1 | Cartagena FCCartagena FC |
| 21 Jul 22 | r03 | AlbaceteAlbacete | 1 - 2 | Valencia MestallaValencia Mest |
| 22 Jul 22 | r03 | LazioLazio | - | VeneziaVenezia |
| 22 Jul 22 | r03 | Mezőkövesdi SEMezőkövesdi S | 3 - 2 | Mlada BoleslavMlada Bolesla |
| 22 Jul 22 | r03 | FC AshdodFC Ashdod | 1 - 1 | SlovackoSlovacko |
| 22 Jul 22 | r03 | Crystal PalaceCrystal Palac | 1 - 1 | LeedsLeeds |
| 22 Jul 22 | r03 | Almere City FCAlmere City F | 1 - 0 | FC DordrechtFC Dordrecht |
| 22 Jul 22 | r03 | VitesseVitesse | 2 - 2 | VVV-VenloVVV-Venlo |
| 22 Jul 22 | r03 | Apollon LimassolApollon Limas | - | LiberecLiberec |
| 22 Jul 22 | r03 | FiorentinaFiorentina | 4 - 1 | TrentoTrento |
| 22 Jul 22 | r03 | Dukla PrahaDukla Praha | 4 - 1 | TepliceTeplice |
| 22 Jul 22 | r03 | GenoaGenoa | 0 - 1 | MallorcaMallorca |
| 22 Jul 22 | r03 | ModenaModena | 1 - 0 | U.S. Fiorenzuola 1922 S.SU.S. Fiorenzu |
| 22 Jul 22 | r03 | SC Dnipro-1SC Dnipro-1 | 0 - 0 | Al Nassr FCAl Nassr FC |
| 22 Jul 22 | r03 | BenficaBenfica | 4 - 2 | GironaGirona |
| 22 Jul 22 | r03 | FC KolnFC Koln | 5 - 0 | NEC NijmegenNEC Nijmegen |
| 22 Jul 22 | r03 | SC Heracles AlmeloSC Heracles A | 2 - 1 | ExcelsiorExcelsior |
| 22 Jul 22 | r03 | SC CambuurSC Cambuur | 3 - 1 | PEC ZwollePEC Zwolle |
| 22 Jul 22 | r03 | PEC ZwollePEC Zwolle | 3 - 1 | SC CambuurSC Cambuur |
| 22 Jul 22 | r03 | SC HeerenveenSC Heerenveen | 1 - 1 | MolenbeekMolenbeek |
| 22 Jul 22 | r03 | PontederaPontedera | 0 - 3 | TernanaTernana |
| 22 Jul 22 | r03 | GrafičarGrafičar | 0 - 0 | PanetolikosPanetolikos |
| 22 Jul 22 | r03 | AB GladsaxeAB Gladsaxe | 1 - 0 | FremFrem |
| 22 Jul 22 | r03 | Fortuna SittardFortuna Sitta | 3 - 3 | Shakhtar DonetskShakhtar Done |
| 22 Jul 22 | r03 | FC VolendamFC Volendam | 1 - 2 | AEKAEK |
| 22 Jul 22 | r03 | Bayern AlzenauBayern Alzena | 2 - 1 | Barockstadt Fulda-LehnerzBarockstadt F |
| 22 Jul 22 | r03 | SV BabelsbergSV Babelsberg | 3 - 2 | St Pauli IISt Pauli II |
| 22 Jul 22 | r03 | ADO Den HaagADO Den Haag | 2 - 1 | Waasland-BeverenWaasland-Beve |
| 22 Jul 22 | r03 | Hessen KasselHessen Kassel | 0 - 2 | Hapoel Ramat HaSharonHapoel Ramat |
| 22 Jul 22 | r03 | EspanolEspanol | 0 - 0 | Las PalmasLas Palmas |
| 22 Jul 22 | r03 | Unionistas de SalamancaUnionistas de | 1 - 2 | ValladolidValladolid |
| 22 Jul 22 | r03 | OJC RosmalenOJC Rosmalen | 2 - 2 | FC Den BoschFC Den Bosch |
| 22 Jul 22 | r03 | FC TwenteFC Twente | 3 - 1 | Schalke 04Schalke 04 |
| 22 Jul 22 | r03 | MiddlesbroughMiddlesbrough | 2 - 0 | MarseilleMarseille |
| 22 Jul 22 | r03 | BurtonBurton | 0 - 3 | Sheffield UnitedSheffield Uni |
| 22 Jul 22 | r03 | KnockbredaKnockbreda | 1 - 1 | PortadownPortadown |
| 22 Jul 22 | r03 | Ballyclare ComradesBallyclare Co | 1 - 1 | Dungannon SwiftsDungannon Swi |
| 22 Jul 22 | r03 | Virtus FrancavillaVirtus Franca | 0 - 1 | LecceLecce |
| 23 Jul 22 | r03 | ModenaModena | - | LuccheseLucchese |
| 23 Jul 22 | r03 | SoroksárSoroksár | 1 - 2 | VasasVasas |
| 23 Jul 22 | r03 | ElcheElche | 2 - 1 | LeganesLeganes |
| 23 Jul 22 | r03 | Rio AveRio Ave | 0 - 2 | Santa ClaraSanta Clara |
| 23 Jul 22 | r03 | TřinecTřinec | 0 - 1 | SFC OpavaSFC Opava |
| 23 Jul 22 | r03 | GranadaGranada | 5 - 0 | Linares DeportivoLinares Depor |
| 23 Jul 22 | r03 | ZlínZlín | 1 - 2 | ProstějovProstějov |
| 23 Jul 22 | r03 | PardubicePardubice | 2 - 0 | VlašimVlašim |
| 23 Jul 22 | r03 | Viktoria ŽižkovViktoria Žižk | 3 - 2 | Sparta Prague BSparta Prague |
| 23 Jul 22 | r03 | PortimonensePortimonense | 2 - 0 | BragaBraga |
| 23 Jul 22 | r03 | ChrudimChrudim | 1 - 4 | Hradec KrálovéHradec Králov |
| 23 Jul 22 | r03 | Paksi FCPaksi FC | 2 - 1 | KozármislenyKozármisleny |
| 23 Jul 22 | r03 | AroucaArouca | 0 - 0 | ChavesChaves |
| 23 Jul 22 | r03 | Stuttgart IIStuttgart II | 0 - 1 | Kickers OffenbachKickers Offen |
| 23 Jul 22 | r03 | TranmereTranmere | 1 - 4 | Huddersfield TownHuddersfield |
| 23 Jul 22 | r03 | Real OviedoReal Oviedo | 0 - 0 | EibarEibar |
| 23 Jul 22 | r03 | Omonia NicosiaOmonia Nicosi | 2 - 1 | GianninaGiannina |
| 23 Jul 22 | r03 | FA 2000FA 2000 | 0 - 1 | Hellerup IKHellerup IK |
| 23 Jul 22 | r03 | Huddersfield TownHuddersfield | 1 - 4 | TranmereTranmere |
| 23 Jul 22 | r03 | Hannover IIHannover II | 1 - 1 | Germania HalberstadtGermania Halb |
| 23 Jul 22 | r03 | Cambridge UnitedCambridge Uni | 1 - 2 | HullHull |
| 23 Jul 22 | r03 | Hertha ZehlendorfHertha Zehlen | - | Viktoria BerlinViktoria Berl |
| 23 Jul 22 | r03 | SwindonSwindon | 2 - 4 | CardiffCardiff |
| 23 Jul 22 | r03 | Kolding IFKolding IF | - | Holstein KielHolstein Kiel |
| 23 Jul 22 | r03 | Holbæk B&IHolbæk B&I | 1 - 4 | RoskildeRoskilde |
| 23 Jul 22 | r03 | FremFrem | 2 - 2 | BrønshøjBrønshøj |
| 23 Jul 22 | r03 | Kolding IFKolding IF | 1 - 0 | Holstein Kiel IIHolstein Kiel |
| 23 Jul 22 | r03 | Bedford TownBedford Town | 1 - 4 | WealdstoneWealdstone |
| 23 Jul 22 | r03 | TOP OssTOP Oss | 2 - 1 | SV TECSV TEC |
| 23 Jul 22 | r03 | Carl Zeiss JenaCarl Zeiss Je | 1 - 3 | Hessen KasselHessen Kassel |
| 23 Jul 22 | r03 | DerbyDerby | 1 - 3 | LeicesterLeicester |
| 23 Jul 22 | r03 | Jong AZJong AZ | - | Amsterdamsche FCAmsterdamsche |
| 23 Jul 22 | r03 | Hoffenheim IIHoffenheim II | 2 - 0 | Astoria WalldorfAstoria Walld |
| 23 Jul 22 | r03 | Mainz IIMainz II | 2 - 2 | Wormatia WormsWormatia Worm |
| 23 Jul 22 | r03 | Chemnitzer FCChemnitzer FC | 2 - 0 | Viktoria BerlinViktoria Berl |
| 23 Jul 22 | r03 | Go Ahead EaglesGo Ahead Eagl | 2 - 0 | Roda JCRoda JC |
| 23 Jul 22 | r03 | MönchengladbachMönchengladba | 1 - 1 | SociedadSociedad |
| 23 Jul 22 | r03 | SC Heracles AlmeloSC Heracles A | - | OFIOFI |
| 23 Jul 22 | r03 | LübeckLübeck | 0 - 0 | LuckenwaldeLuckenwalde |
| 23 Jul 22 | r03 | LincolnLincoln | 0 - 1 | BlackburnBlackburn |
| 23 Jul 22 | r03 | AccringtonAccrington | 2 - 1 | SunderlandSunderland |
| 23 Jul 22 | r03 | Beerschot VABeerschot VA | 1 - 0 | SpartaSparta |
| 23 Jul 22 | r03 | Newry City AFCNewry City AF | 0 - 1 | NewingtonNewington |
| 23 Jul 22 | r03 | Carrick RangersCarrick Range | 0 - 1 | Banbridge TownBanbridge Tow |
| 23 Jul 22 | r03 | Chemnitzer FCChemnitzer FC | - | Slavia Prague BSlavia Prague |
| 23 Jul 22 | r03 | QPRQPR | 0 - 3 | Crystal PalaceCrystal Palac |
| 23 Jul 22 | r03 | Moyola ParkMoyola Park | 0 - 2 | Dungannon SwiftsDungannon Swi |
| 23 Jul 22 | r03 | ValenciennesValenciennes | 2 - 1 | BoulogneBoulogne |
| 23 Jul 22 | r03 | StuttgartStuttgart | 5 - 2 | ValenciaValencia |
| 23 Jul 22 | r03 | AugsburgAugsburg | - | RennesRennes |
| 23 Jul 22 | r03 | HoffenheimHoffenheim | - | VeronaVerona |
| 23 Jul 22 | r03 | Hungerford TownHungerford To | 3 - 1 | Maidenhead UnitedMaidenhead Un |
| 23 Jul 22 | r03 | Banik OstravaBanik Ostrava | 2 - 1 | KarvinaKarvina |
| 23 Jul 22 | r03 | CelticCeltic | 2 - 0 | NorwichNorwich |
| 23 Jul 22 | r03 | YeovilYeovil | 0 - 2 | PlymouthPlymouth |
| 23 Jul 22 | r03 | Dagenham & Red.Dagenham & Re | 2 - 2 | Leyton OrientLeyton Orient |
| 23 Jul 22 | r03 | TorquayTorquay | 1 - 0 | ExeterExeter |
| 23 Jul 22 | r03 | MorecambeMorecambe | 0 - 0 | CarlisleCarlisle |
| 23 Jul 22 | r03 | LeatherheadLeatherhead | 3 - 2 | Dorking WanderersDorking Wande |
| 23 Jul 22 | r03 | Folkestone InvictaFolkestone In | 1 - 2 | MaidstoneMaidstone |
| 23 Jul 22 | r03 | ScunthorpeScunthorpe | 1 - 1 | PeterboroPeterboro |
| 23 Jul 22 | r03 | AFC WimbledonAFC Wimbledon | 0 - 0 | Oxford UtdOxford Utd |
| 23 Jul 22 | r03 | SouthendSouthend | 0 - 1 | GillinghamGillingham |
| 23 Jul 22 | r03 | CharltonCharlton | 1 - 2 | SwanseaSwansea |
| 23 Jul 22 | r03 | BarnsleyBarnsley | 2 - 1 | Sheffield UnitedSheffield Uni |
| 23 Jul 22 | r03 | WolfsburgWolfsburg | 4 - 0 | BrentfordBrentford |
| 23 Jul 22 | r03 | AltrinchamAltrincham | 0 - 2 | StockportStockport |
| 23 Jul 22 | r03 | De GraafschapDe Graafschap | - | SC TelstarSC Telstar |
| 23 Jul 22 | r03 | Sutton UnitedSutton United | 3 - 2 | BromleyBromley |
| 23 Jul 22 | r03 | FC United of ManchesterFC United of | 0 - 3 | DoncasterDoncaster |
| 23 Jul 22 | r03 | DartfordDartford | 2 - 2 | Boreham WoodBoreham Wood |
| 23 Jul 22 | r03 | ChesterfieldChesterfield | 3 - 0 | BradfordBradford |
| 23 Jul 22 | r03 | MillwallMillwall | 1 - 1 | IpswichIpswich |
| 23 Jul 22 | r03 | Fleetwood TownFleetwood Tow | 2 - 1 | Dundee UnitedDundee United |
| 23 Jul 22 | r03 | PortsmouthPortsmouth | 0 - 2 | CoventryCoventry |
| 23 Jul 22 | r03 | BoltonBolton | 1 - 1 | Huddersfield TownHuddersfield |
| 23 Jul 22 | r03 | LutonLuton | 1 - 1 | West HamWest Ham |
| 23 Jul 22 | r03 | Farsley CelticFarsley Celti | 2 - 1 | HalifaxHalifax |
| 23 Jul 22 | r03 | OldhamOldham | 0 - 3 | MansfieldMansfield |
| 23 Jul 22 | r03 | DundelaDundela | 1 - 1 | GlentoranGlentoran |
| 23 Jul 22 | r03 | Peterborough SportsPeterborough | 0 - 0 | StevenageStevenage |
| 23 Jul 22 | r03 | BournemouthBournemouth | 0 - 1 | Bristol CityBristol City |
| 23 Jul 22 | r03 | CreweCrewe | 1 - 2 | RotherhamRotherham |
| 23 Jul 22 | r03 | PrestonPreston | 1 - 2 | LeicesterLeicester |
| 23 Jul 22 | r03 | ReadingReading | 1 - 2 | BrightonBrighton |
| 23 Jul 22 | r03 | Harrogate Town FCHarrogate Tow | 3 - 1 | Gateshead FCGateshead FC |
| 23 Jul 22 | r03 | NantesNantes | 2 - 0 | LorientLorient |
| 23 Jul 22 | r03 | ColeraineColeraine | 5 - 0 | Ballinamallard UnitedBallinamallar |
| 23 Jul 22 | r03 | CheltenhamCheltenham | 2 - 0 | NorthamptonNorthampton |
| 23 Jul 22 | r03 | Forest Green RoversForest Green | 1 - 1 | NewportNewport |
| 23 Jul 22 | r03 | CrusadersCrusaders | - | InstituteInstitute |
| 23 Jul 22 | r03 | H and W WeldersH and W Welde | 0 - 1 | Ballymena UnitedBallymena Uni |
| 23 Jul 22 | r03 | Willem IIWillem II | 5 - 0 | LyonLyon |
| 23 Jul 22 | r03 | AldershotAldershot | 3 - 2 | CrawleyCrawley |
| 23 Jul 22 | r03 | West BromWest Brom | 2 - 1 | HerthaHertha |
| 23 Jul 22 | r03 | WatfordWatford | 0 - 0 | SouthamptonSouthampton |
| 23 Jul 22 | r03 | BarnetBarnet | 1 - 3 | Milton Keynes DonsMilton Keynes |
| 23 Jul 22 | r03 | RochdaleRochdale | 2 - 3 | Port ValePort Vale |
| 23 Jul 22 | r03 | Limavady UnitedLimavady Unit | 1 - 1 | Ballymena UnitedBallymena Uni |
| 23 Jul 22 | r03 | StokeStoke | 2 - 1 | HeartsHearts |
| 23 Jul 22 | r03 | WiganWigan | 4 - 1 | Sheffield WedsSheffield Wed |
| 23 Jul 22 | r03 | ColchesterColchester | 2 - 2 | Ebbsfleet UnitedEbbsfleet Uni |
| 23 Jul 22 | r03 | BirminghamBirmingham | 2 - 2 | VallecanoVallecano |
| 23 Jul 22 | r03 | MacclesfieldMacclesfield | 4 - 0 | YorkYork |
| 23 Jul 22 | r03 | LoughgallLoughgall | 0 - 2 | LinfieldLinfield |
| 23 Jul 22 | r03 | Solihull MoorsSolihull Moor | 0 - 2 | WalsallWalsall |
| 23 Jul 22 | r03 | Ebbsfleet UnitedEbbsfleet Uni | 2 - 2 | ColchesterColchester |
| 23 Jul 22 | r03 | Gateshead FCGateshead FC | 1 - 3 | Harrogate Town FCHarrogate Tow |
| 23 Jul 22 | r03 | Vysočina JihlavaVysočina Jihl | 0 - 0 | Zbrojovka BrnoZbrojovka Brn |
| 23 Jul 22 | r03 | NAC BredaNAC Breda | 1 - 0 | FC EindhovenFC Eindhoven |
| 23 Jul 22 | r03 | FiorentinaFiorentina | 4 - 0 | TriestinaTriestina |
| 23 Jul 22 | r03 | PeterboroPeterboro | 3 - 0 | HullHull |
| 23 Jul 22 | r03 | GuingampGuingamp | 2 - 0 | BrestBrest |
| 23 Jul 22 | r03 | GrenobleGrenoble | 2 - 0 | Red StarRed Star |
| 23 Jul 22 | r03 | Rot-Weiß ErfurtRot-Weiß Erfu | 1 - 2 | TSV Steinbach HaigerTSV Steinbach |
| 23 Jul 22 | r03 | Union BerlinUnion Berlin | 1 - 0 | Nottingham ForestNottingham Fo |
| 23 Jul 22 | r03 | CaenCaen | 0 - 0 | FC Versailles 78FC Versailles |
| 23 Jul 22 | r03 | AngersAngers | 4 - 1 | St EtienneSt Etienne |
| 23 Jul 22 | r03 | TorinoTorino | - | Al WahdaAl Wahda |
| 23 Jul 22 | r03 | Werder BremenWerder Bremen | 6 - 1 | FC GroningenFC Groningen |
| 23 Jul 22 | r03 | Parma Calcio 1913Parma Calcio | 2 - 0 | FeralpisalòFeralpisalò |
| 23 Jul 22 | r03 | MainzMainz | 1 - 1 | Ath BilbaoAth Bilbao |
| 23 Jul 22 | r03 | AtalantaAtalanta | 4 - 0 | ComoComo |
| 23 Jul 22 | r03 | Werder BremenWerder Bremen | 0 - 0 | FC EmmenFC Emmen |
| 23 Jul 22 | r03 | MetzMetz | 1 - 0 | SochauxSochaux |
| 23 Jul 22 | r03 | Paksi FCPaksi FC | 2 - 0 | PécsPécs |
| 23 Jul 22 | r03 | ValenciennesValenciennes | 0 - 0 | USL DunkerqueUSL Dunkerque |
| 23 Jul 22 | r03 | LavalLaval | 3 - 1 | SO CholetSO Cholet |
| 23 Jul 22 | r03 | Paris FCParis FC | 1 - 0 | AjaccioAjaccio |
| 23 Jul 22 | r03 | BresciaBrescia | 0 - 2 | SampdoriaSampdoria |
| 23 Jul 22 | r03 | Clermont FootClermont Foot | 2 - 0 | Rodez AFRodez AF |
| 23 Jul 22 | r03 | FrosinoneFrosinone | 1 - 0 | BariBari |
| 23 Jul 22 | r03 | BeneventoBenevento | 0 - 1 | CosenzaCosenza |
| 23 Jul 22 | r03 | MafraMafra | 2 - 3 | SC FarenseSC Farense |
| 23 Jul 22 | r03 | Montevarchi Calcio AquilaMontevarchi C | 0 - 4 | TernanaTernana |
| 23 Jul 22 | r03 | Lleida EsportiuLleida Esport | 1 - 3 | ZaragozaZaragoza |
| 23 Jul 22 | r03 | Go Ahead EaglesGo Ahead Eagl | 0 - 2 | Jong UtrechtJong Utrecht |
| 23 Jul 22 | r03 | Lierse KempenzonenLierse Kempen | 0 - 1 | Helmond SportHelmond Sport |
| 23 Jul 22 | r03 | AuxerreAuxerre | 1 - 0 | TroyesTroyes |
| 23 Jul 22 | r03 | NiortNiort | 1 - 0 | Pau FCPau FC |
| 23 Jul 22 | r03 | VasasVasas | 0 - 1 | DiosgyorDiosgyor |
| 23 Jul 22 | r03 | BastiaBastia | 1 - 0 | MartiguesMartigues |
| 23 Jul 22 | r03 | AmiensAmiens | 1 - 1 | QuevillyQuevilly |
| 23 Jul 22 | r03 | MontpellierMontpellier | 4 - 5 | ToulouseToulouse |
| 23 Jul 22 | r03 | OlbiaOlbia | 0 - 3 | CagliariCagliari |
| 23 Jul 22 | r03 | CadizCadiz | 2 - 0 | MalagaMalaga |
| 23 Jul 22 | r03 | Cartagena FCCartagena FC | 0 - 3 | Sp GijonSp Gijon |
| 23 Jul 22 | r03 | BurgosBurgos | 0 - 0 | ValladolidValladolid |
| 23 Jul 22 | r03 | LeonesaLeonesa | 1 - 1 | SantanderSantander |
| 23 Jul 22 | r03 | AlavesAlaves | 5 - 0 | CF IntercityCF Intercity |
| 23 Jul 22 | r03 | LilleLille | 2 - 2 | Las PalmasLas Palmas |
| 23 Jul 22 | r03 | SD LogroñésSD Logroñés | 1 - 1 | MirandesMirandes |
| 23 Jul 22 | r03 | OsasunaOsasuna | 4 - 3 | HuescaHuesca |
| 23 Jul 22 | r03 | OurenseOurense | 0 - 3 | LugoLugo |
| 23 Jul 22 | r03 | Paris FCParis FC | 2 - 0 | CreteilCreteil |
| 23 Jul 22 | r03 | AlmeriaAlmeria | 1 - 2 | CordobaCordoba |
| 23 Jul 22 | r03 | FC PortoFC Porto | 2 - 1 | MonacoMonaco |
| 24 Jul 22 | r03 | FC LvivFC Lviv | - | Veres RivneVeres Rivne |
| 24 Jul 22 | r03 | AlbaceteAlbacete | 2 - 1 | UCAM MurciaUCAM Murcia |
| 24 Jul 22 | r03 | EspanolEspanol | 2 - 0 | LilleLille |
| 24 Jul 22 | r03 | LevanteLevante | 0 - 0 | GetafeGetafe |
| 24 Jul 22 | r03 | Villarreal BVillarreal B | 2 - 1 | WolvesWolves |
| 24 Jul 22 | r03 | Cracovia KrakowCracovia Krak | 3 - 0 | Hapoel JerusalemHapoel Jerusa |
| 24 Jul 22 | r03 | Berliner AK 07Berliner AK 0 | 0 - 0 | Atlas DelmenhorstAtlas Delmenh |
| 24 Jul 22 | r03 | Berliner FC DynamoBerliner FC D | 2 - 0 | NeustrelitzNeustrelitz |
| 24 Jul 22 | r03 | Blau-Weiß LohneBlau-Weiß Loh | 1 - 3 | FC GroningenFC Groningen |
| 24 Jul 22 | r03 | Lokomotive LeipzigLokomotive Le | 0 - 0 | Ústí nad LabemÚstí nad Labe |
| 24 Jul 22 | r03 | FSV FrankfurtFSV Frankfurt | 6 - 1 | FC GießenFC Gießen |
| 24 Jul 22 | r03 | HibernianHibernian | 1 - 0 | NorwichNorwich |
| 24 Jul 22 | r03 | Slavia PragueSlavia Prague | 2 - 4 | LíšeňLíšeň |
| 24 Jul 22 | r03 | Bohemians 1905Bohemians 190 | 2 - 2 | PribramPribram |
| 24 Jul 22 | r03 | Dynamo České BudějoviceDynamo České | 4 - 0 | TáborskoTáborsko |
| 24 Jul 22 | r03 | Cray WanderersCray Wanderer | - | MaidstoneMaidstone |
| 24 Jul 22 | r03 | BlackpoolBlackpool | 2 - 4 | EvertonEverton |
| 24 Jul 22 | r03 | PanathinaikosPanathinaikos | 0 - 0 | NFC VolosNFC Volos |
| 24 Jul 22 | r03 | CremoneseCremonese | 2 - 0 | SPAL 2013SPAL 2013 |
| 24 Jul 22 | r03 | AZ AlkmaarAZ Alkmaar | 1 - 0 | BolognaBologna |
| 24 Jul 22 | r03 | AtromitosAtromitos | 0 - 1 | Hapoel Kiryat ShmonaHapoel Kiryat |
| 24 Jul 22 | r03 | CottbusCottbus | 2 - 0 | VfV HildesheimVfV Hildeshei |
| 24 Jul 22 | r03 | DebrecenDebrecen | 1 - 0 | Veres RivneVeres Rivne |
| 24 Jul 22 | r03 | Estoril-PraiaEstoril-Praia | 1 - 3 | FulhamFulham |
| 24 Jul 22 | r03 | Stade de ReimsStade de Reim | 0 - 1 | VillarrealVillarreal |
| 24 Jul 22 | r03 | UD IbizaUD Ibiza | 2 - 2 | EldenseEldense |
| 24 Jul 22 | r03 | Racing Club de FerrolRacing Club d | 1 - 2 | PonferradinaPonferradina |
| 24 Jul 22 | r03 | San Fernando CDSan Fernando | 2 - 3 | AlmeriaAlmeria |
| 24 Jul 22 | r03 | Sporting CPSporting CP | 1 - 1 | SevillaSevilla |
| 25 Jul 22 | r03 | Tasmania BerlinTasmania Berl | - | Berliner AK 07Berliner AK 0 |
| 25 Jul 22 | r03 | UdineseUdinese | 2 - 1 | Pafos FCPafos FC |
| 25 Jul 22 | r03 | MonzaMonza | 4 - 0 | RenateRenate |
| 25 Jul 22 | r03 | Mladost LučaniMladost Lučan | - | PanetolikosPanetolikos |
| 25 Jul 22 | r03 | HartlepoolHartlepool | 1 - 1 | SunderlandSunderland |
| 25 Jul 22 | r03 | BangorBangor | - | Carrick RangersCarrick Range |
| 26 Jul 22 | r03 | ZoryaZorya | 5 - 3 | Polissya ZhytomyrPolissya Zhyt |
| 26 Jul 22 | r03 | Omonia NicosiaOmonia Nicosi | 2 - 0 | Hapoel JerusalemHapoel Jerusa |
| 26 Jul 22 | r03 | Truro CityTruro City | - | PlymouthPlymouth |
| 26 Jul 22 | r03 | AueAue | - | Berliner AK 07Berliner AK 0 |
| 26 Jul 22 | r03 | BrightonBrighton | 0 - 1 | BrentfordBrentford |
| 26 Jul 22 | r03 | MiddelfartMiddelfart | 1 - 0 | Kolding IFKolding IF |
| 26 Jul 22 | r03 | VVV-VenloVVV-Venlo | 1 - 2 | AtromitosAtromitos |
| 26 Jul 22 | r03 | VitesseVitesse | 1 - 2 | OFIOFI |
| 26 Jul 22 | r03 | Lamezia TermeLamezia Terme | 0 - 12 | RegginaReggina |
| 26 Jul 22 | r03 | Dorchester TownDorchester To | 0 - 0 | YeovilYeovil |
| 26 Jul 22 | r03 | IpswichIpswich | 3 - 1 | SouthendSouthend |
| 26 Jul 22 | r03 | SC TelstarSC Telstar | 1 - 0 | IJsselmeervogelsIJsselmeervog |
| 26 Jul 22 | r03 | WalthamstowWalthamstow | - | Leyton OrientLeyton Orient |
| 26 Jul 22 | r03 | SouthportSouthport | - | BoltonBolton |
| 26 Jul 22 | r03 | Stratford TownStratford Tow | 1 - 4 | WokingWoking |
| 26 Jul 22 | r03 | AFC TottonAFC Totton | 2 - 2 | AldershotAldershot |
| 26 Jul 22 | r03 | Potters Bar TownPotters Bar T | 1 - 1 | Boreham WoodBoreham Wood |
| 26 Jul 22 | r03 | DundelaDundela | 3 - 0 | PortadownPortadown |
| 26 Jul 22 | r03 | Stamford AFCStamford AFC | 5 - 0 | StevenageStevenage |
| 26 Jul 22 | r03 | Newry City AFCNewry City AF | 0 - 2 | Warrenpoint TownWarrenpoint T |
| 26 Jul 22 | r03 | Tobermore UnitedTobermore Uni | 1 - 3 | Ballymena UnitedBallymena Uni |
| 26 Jul 22 | r03 | Cray Valley PMCray Valley P | 0 - 5 | MaidstoneMaidstone |
| 26 Jul 22 | r03 | Bradford Park AvenueBradford Park | 0 - 1 | ScunthorpeScunthorpe |
| 26 Jul 22 | r03 | Concord RangersConcord Range | 1 - 1 | Dagenham & Red.Dagenham & Re |
| 26 Jul 22 | r03 | RadcliffeRadcliffe | 1 - 2 | OldhamOldham |
| 26 Jul 22 | r03 | WealdstoneWealdstone | 1 - 5 | BillericayBillericay |
| 26 Jul 22 | r03 | Carrick RangersCarrick Range | 4 - 4 | ArdsArds |
| 26 Jul 22 | r03 | Ballyclare ComradesBallyclare Co | 1 - 2 | Ballymena UnitedBallymena Uni |
| 26 Jul 22 | r03 | Nottingham ForestNottingham Fo | 2 - 2 | Notts CountyNotts County |
| 26 Jul 22 | r03 | Annagh UnitedAnnagh United | 4 - 2 | Dungannon SwiftsDungannon Swi |
| 26 Jul 22 | r03 | Alfreton TownAlfreton Town | 2 - 1 | DerbyDerby |
| 26 Jul 22 | r03 | CliftonvilleCliftonville | 4 - 0 | BangorBangor |
| 26 Jul 22 | r03 | BenficaBenfica | 3 - 2 | NewcastleNewcastle |
| 27 Jul 22 | r03 | Anorthosis FamagustaAnorthosis Fa | 2 - 3 | Hapoel Petah TikvaHapoel Petah |
| 27 Jul 22 | r03 | VizelaVizela | 2 - 3 | Gil VicenteGil Vicente |
| 27 Jul 22 | r03 | PortimonensePortimonense | 1 - 0 | CovilhaCovilha |
| 27 Jul 22 | r03 | MafraMafra | 1 - 0 | VilafranquenseVilafranquens |
| 27 Jul 22 | r03 | MontalegreMontalegre | 0 - 2 | ChavesChaves |
| 27 Jul 22 | r03 | Anorthosis FamagustaAnorthosis Fa | - | Maccabi Petach TikvaMaccabi Petac |
| 27 Jul 22 | r03 | FC UtrechtFC Utrecht | 0 - 1 | AEKAEK |
| 27 Jul 22 | r03 | Doxa KatokopiasDoxa Katokopi | 3 - 1 | Olympiakos NicosiaOlympiakos Ni |
| 27 Jul 22 | r03 | NantesNantes | 0 - 1 | RennesRennes |
| 27 Jul 22 | r03 | Al SharjahAl Sharjah | 1 - 2 | NK VaraždinNK Varaždin |
| 27 Jul 22 | r03 | Astoria WalldorfAstoria Walld | 0 - 5 | Ein FrankfurtEin Frankfurt |
| 27 Jul 22 | r03 | GenoaGenoa | 4 - 1 | LazioLazio |
| 27 Jul 22 | r03 | TorinoTorino | 1 - 0 | Apollon LimassolApollon Limas |
| 27 Jul 22 | r03 | BresciaBrescia | 5 - 1 | LeccoLecco |
| 27 Jul 22 | r03 | Stuttgart IIStuttgart II | 0 - 2 | TSG BalingenTSG Balingen |
| 27 Jul 22 | r03 | Athletic Bilbao BAthletic Bilb | 0 - 0 | MirandesMirandes |
| 27 Jul 22 | r03 | SociedadSociedad | 1 - 0 | OsasunaOsasuna |
| 27 Jul 22 | r03 | Al ShababAl Shabab | 2 - 1 | Las PalmasLas Palmas |
| 27 Jul 22 | r03 | ZFC MeuselwitzZFC Meuselwit | 6 - 3 | VfB AuerbachVfB Auerbach |
| 27 Jul 22 | r03 | MafraMafra | 1 - 2 | Atlético PetróleosAtlético Petr |
| 27 Jul 22 | r03 | LorientLorient | 2 - 1 | ChateaurouxChateauroux |
| 27 Jul 22 | r03 | Real OviedoReal Oviedo | 0 - 1 | BurgosBurgos |
| 27 Jul 22 | r03 | StrasbourgStrasbourg | 1 - 2 | CagliariCagliari |
| 27 Jul 22 | r03 | LeganesLeganes | 1 - 2 | VallecanoVallecano |
| 27 Jul 22 | r03 | CD TeruelCD Teruel | 0 - 0 | ZaragozaZaragoza |
| 27 Jul 22 | r03 | CalahorraCalahorra | 0 - 1 | HuescaHuesca |
| 27 Jul 22 | r03 | AlbaceteAlbacete | 4 - 2 | Rayo MajadahondaRayo Majadaho |
| 27 Jul 22 | r03 | MallorcaMallorca | 1 - 0 | Sp GijonSp Gijon |
| 27 Jul 22 | r03 | H and W WeldersH and W Welde | 1 - 2 | GlenavonGlenavon |
| 27 Jul 22 | r03 | BetisBetis | 1 - 1 | MarseilleMarseille |
| 27 Jul 22 | r03 | Calcio PadovaCalcio Padova | 1 - 5 | SpeziaSpezia |
| 27 Jul 22 | r03 | SevillaSevilla | 6 - 0 | AngersAngers |
| 27 Jul 22 | r03 | SouthamptonSouthampton | 3 - 1 | MonacoMonaco |
| 28 Jul 22 | r03 | LamiaLamia | - | AE LarissaAE Larissa |
| 28 Jul 22 | r03 | EspanolEspanol | 0 - 1 | LinenseLinense |
| 28 Jul 22 | r03 | EmpoliEmpoli | 2 - 1 | Pafos FCPafos FC |
| 28 Jul 22 | r03 | Rot-Weiß KoblenzRot-Weiß Kobl | 0 - 2 | Viktoria KölnViktoria Köln |
| 28 Jul 22 | r03 | PanathinaikosPanathinaikos | 2 - 1 | FC VolendamFC Volendam |
| 28 Jul 22 | r03 | PonferradinaPonferradina | 1 - 2 | ValladolidValladolid |
| 28 Jul 22 | r03 | Warrenpoint TownWarrenpoint T | 0 - 1 | LarneLarne |
| 29 Jul 22 | r03 | Kolding IFKolding IF | - | DalumDalum |
| 29 Jul 22 | r03 | Veres RivneVeres Rivne | 3 - 1 | MynaiMynai |
| 29 Jul 22 | r03 | EsbjergEsbjerg | 1 - 2 | Skive IKSkive IK |
| 29 Jul 22 | r03 | Almere City FCAlmere City F | 3 - 2 | FC Den BoschFC Den Bosch |
| 29 Jul 22 | r03 | BeneventoBenevento | 0 - 0 | SienaSiena |
| 29 Jul 22 | r03 | Lokomotive LeipzigLokomotive Le | 1 - 4 | Hallescher FCHallescher FC |
| 29 Jul 22 | r03 | FC AndorraFC Andorra | 3 - 1 | Espanyol BEspanyol B |
| 29 Jul 22 | r03 | EibarEibar | 5 - 2 | SD AmorebietaSD Amorebieta |
| 29 Jul 22 | r03 | SC Heracles AlmeloSC Heracles A | 1 - 3 | NEC NijmegenNEC Nijmegen |
| 29 Jul 22 | r03 | Go Ahead EaglesGo Ahead Eagl | 4 - 1 | OFIOFI |
| 29 Jul 22 | r03 | B.93B.93 | 1 - 3 | RoskildeRoskilde |
| 29 Jul 22 | r03 | Hallescher FCHallescher FC | 1 - 4 | Lokomotive LeipzigLokomotive Le |
| 29 Jul 22 | r03 | ADO Den HaagADO Den Haag | - | FC VolendamFC Volendam |
| 29 Jul 22 | r03 | FC TwenteFC Twente | 4 - 1 | BolognaBologna |
| 29 Jul 22 | r03 | CadizCadiz | 0 - 1 | LilleLille |
| 29 Jul 22 | r03 | Boston United FCBoston United | 0 - 2 | ChesterfieldChesterfield |
| 29 Jul 22 | r03 | GlentoranGlentoran | 2 - 1 | H and W WeldersH and W Welde |
| 29 Jul 22 | r03 | GimnasticGimnastic | 3 - 3 | ZaragozaZaragoza |
| 29 Jul 22 | r03 | PortstewartPortstewart | 1 - 4 | ColeraineColeraine |
| 29 Jul 22 | r03 | Parma Calcio 1913Parma Calcio | 1 - 0 | LecceLecce |
| 29 Jul 22 | r03 | EastleighEastleigh | 2 - 1 | Hungerford TownHungerford To |
| 29 Jul 22 | r03 | NewcastleNewcastle | 1 - 0 | AtalantaAtalanta |
| 29 Jul 22 | r03 | EvertonEverton | 3 - 0 | Dynamo KievDynamo Kiev |
| 29 Jul 22 | r03 | BragaBraga | 2 - 1 | Celta VigoCelta Vigo |
| 29 Jul 22 | r03 | MaritimoMaritimo | 1 - 0 | Santa ClaraSanta Clara |
| 30 Jul 22 | r03 | VfB HombergVfB Homberg | - | ExcelsiorExcelsior |
| 30 Jul 22 | r03 | Rot-Weiß ErfurtRot-Weiß Erfu | 1 - 1 | Barockstadt Fulda-LehnerzBarockstadt F |
| 30 Jul 22 | r03 | AEL LimassolAEL Limassol | 1 - 0 | AEZAEZ |
| 30 Jul 22 | r03 | PortimonensePortimonense | 2 - 1 | Estoril-PraiaEstoril-Praia |
| 30 Jul 22 | r03 | SC Heracles AlmeloSC Heracles A | 5 - 0 | De TreffersDe Treffers |
| 30 Jul 22 | r03 | PisaPisa | 2 - 0 | EntellaEntella |
| 30 Jul 22 | r03 | ToulouseToulouse | 0 - 1 | Clermont FootClermont Foot |
| 30 Jul 22 | r03 | NavalcarneroNavalcarnero | 1 - 2 | Alcorcón BAlcorcón B |
| 30 Jul 22 | r03 | MafraMafra | - | AmoraAmora |
| 30 Jul 22 | r03 | HuescaHuesca | 1 - 3 | EibarEibar |
| 30 Jul 22 | r03 | PenafielPenafiel | 2 - 0 | VizelaVizela |
| 30 Jul 22 | r03 | FremFrem | 3 - 1 | Holbæk B&IHolbæk B&I |
| 30 Jul 22 | r03 | ThistedThisted | 2 - 0 | Young BoysYoung Boys |
| 30 Jul 22 | r03 | Lichtenberg 47Lichtenberg 4 | - | Tasmania BerlinTasmania Berl |
| 30 Jul 22 | r03 | FC EilenburgFC Eilenburg | 2 - 2 | ZFC MeuselwitzZFC Meuselwit |
| 30 Jul 22 | r03 | SpartaSparta | 3 - 1 | FC EmmenFC Emmen |
| 30 Jul 22 | r03 | AB GladsaxeAB Gladsaxe | 5 - 1 | FA 2000FA 2000 |
| 30 Jul 22 | r03 | PEC ZwollePEC Zwolle | 2 - 1 | FC DordrechtFC Dordrecht |
| 30 Jul 22 | r03 | CurzonCurzon | 0 - 3 | HalifaxHalifax |
| 30 Jul 22 | r03 | St Albans CitySt Albans Cit | 2 - 1 | BarnetBarnet |
| 30 Jul 22 | r03 | VSG AltglienickeVSG Altglieni | 2 - 2 | Bischofswerdaer FVBischofswerda |
| 30 Jul 22 | r03 | Jong PSVJong PSV | 1 - 2 | Al JaziraAl Jazira |
| 30 Jul 22 | r03 | Optik RathenowOptik Ratheno | 2 - 2 | Germania HalberstadtGermania Halb |
| 30 Jul 22 | r03 | FC HomburgFC Homburg | 4 - 0 | FCSR HaguenauFCSR Haguenau |
| 30 Jul 22 | r03 | Hoffenheim IIHoffenheim II | 5 - 0 | FolaFola |
| 30 Jul 22 | r03 | MiddelfartMiddelfart | 3 - 2 | Aarhus FremadAarhus Fremad |
| 30 Jul 22 | r03 | SC Heracles AlmeloSC Heracles A | - | FC VolendamFC Volendam |
| 30 Jul 22 | r03 | GlenavonGlenavon | 3 - 1 | DergviewDergview |
| 30 Jul 22 | r03 | YorkYork | 0 - 1 | Notts CountyNotts County |
| 30 Jul 22 | r03 | ColeraineColeraine | 4 - 1 | Annagh UnitedAnnagh United |
| 30 Jul 22 | r03 | Carrick RangersCarrick Range | 2 - 0 | Ballyclare ComradesBallyclare Co |
| 30 Jul 22 | r03 | NewcastleNewcastle | 2 - 1 | Ath BilbaoAth Bilbao |
| 30 Jul 22 | r03 | FC GroningenFC Groningen | 2 - 1 | OsasunaOsasuna |
| 30 Jul 22 | r03 | Havant & WaterloovilleHavant & Wate | 0 - 0 | AldershotAldershot |
| 30 Jul 22 | r03 | FarnboroughFarnborough | 1 - 0 | Maidenhead UnitedMaidenhead Un |
| 30 Jul 22 | r03 | Dorking WanderersDorking Wande | - | HorshamHorsham |
| 30 Jul 22 | r03 | ColneColne | 2 - 1 | HalifaxHalifax |
| 30 Jul 22 | r03 | Weston-super-Mare FCWeston-super- | 0 - 1 | YeovilYeovil |
| 30 Jul 22 | r03 | Concord RangersConcord Range | 2 - 1 | SouthendSouthend |
| 30 Jul 22 | r03 | Hampton & RichmondHampton & Ric | 0 - 1 | WokingWoking |
| 30 Jul 22 | r03 | Farsley CelticFarsley Celti | 1 - 5 | ScunthorpeScunthorpe |
| 30 Jul 22 | r03 | Beerschot VABeerschot VA | 2 - 2 | FC EindhovenFC Eindhoven |
| 30 Jul 22 | r03 | BournemouthBournemouth | 1 - 2 | SociedadSociedad |
| 30 Jul 22 | r03 | De GraafschapDe Graafschap | 1 - 0 | Roda JCRoda JC |
| 30 Jul 22 | r03 | CliftonvilleCliftonville | 6 - 1 | Warrenpoint TownWarrenpoint T |
| 30 Jul 22 | r03 | BrentfordBrentford | 1 - 0 | BetisBetis |
| 30 Jul 22 | r03 | AFC FyldeAFC Fylde | 2 - 1 | OldhamOldham |
| 30 Jul 22 | r03 | SouthamptonSouthampton | 1 - 2 | VillarrealVillarreal |
| 30 Jul 22 | r03 | WealdstoneWealdstone | 0 - 3 | ChelmsfordChelmsford |
| 30 Jul 22 | r03 | KnockbredaKnockbreda | 2 - 4 | CrusadersCrusaders |
| 30 Jul 22 | r03 | MaidstoneMaidstone | 2 - 2 | Dulwich HamletDulwich Hamle |
| 30 Jul 22 | r03 | Crystal PalaceCrystal Palac | 4 - 2 | MontpellierMontpellier |
| 30 Jul 22 | r03 | BrightonBrighton | 5 - 1 | EspanolEspanol |
| 30 Jul 22 | r03 | Ballinamallard UnitedBallinamallar | 1 - 2 | PortadownPortadown |
| 30 Jul 22 | r03 | WrexhamWrexham | 4 - 0 | MacclesfieldMacclesfield |
| 30 Jul 22 | r03 | Truro CityTruro City | 1 - 3 | TorquayTorquay |
| 30 Jul 22 | r03 | FC UtrechtFC Utrecht | 2 - 2 | Shakhtar DonetskShakhtar Done |
| 30 Jul 22 | r03 | VeneziaVenezia | 6 - 0 | Dolomiti BellunesiDolomiti Bell |
| 30 Jul 22 | r03 | Waasland-BeverenWaasland-Beve | 2 - 1 | Helmond SportHelmond Sport |
| 30 Jul 22 | r03 | RennesRennes | 1 - 2 | Aston VillaAston Villa |
| 30 Jul 22 | r03 | CittadellaCittadella | 2 - 0 | TrentoTrento |
| 30 Jul 22 | r03 | Bonner SCBonner SC | 1 - 5 | TSV Steinbach HaigerTSV Steinbach |
| 30 Jul 22 | r03 | NiceNice | 1 - 0 | TorinoTorino |
| 30 Jul 22 | r03 | L.R. Vicenza VirtusL.R. Vicenza | 6 - 0 | Calcio MontebellunaCalcio Monteb |
| 30 Jul 22 | r03 | LorientLorient | 1 - 1 | AjaccioAjaccio |
| 30 Jul 22 | r03 | LensLens | 0 - 0 | West HamWest Ham |
| 30 Jul 22 | r03 | MonzaMonza | 5 - 0 | NovaraNovara |
| 30 Jul 22 | r03 | U.S.D. Recanatese 1923U.S.D. Recana | 1 - 4 | AscoliAscoli |
| 30 Jul 22 | r03 | SPAL 2013SPAL 2013 | 1 - 0 | PontederaPontedera |
| 30 Jul 22 | r03 | AuxerreAuxerre | 3 - 2 | Red StarRed Star |
| 30 Jul 22 | r03 | Lommel SKLommel SK | 1 - 3 | Willem IIWillem II |
| 30 Jul 22 | r03 | VeronaVerona | 4 - 3 | CremoneseCremonese |
| 30 Jul 22 | r03 | BresciaBrescia | 4 - 1 | MantovaMantova |
| 30 Jul 22 | r03 | FrosinoneFrosinone | 3 - 2 | TernanaTernana |
| 30 Jul 22 | r03 | RKC WaalwijkRKC Waalwijk | 1 - 1 | SC CambuurSC Cambuur |
| 30 Jul 22 | r03 | Omonia NicosiaOmonia Nicosi | 2 - 0 | Anorthosis FamagustaAnorthosis Fa |
| 30 Jul 22 | r03 | AlavesAlaves | 0 - 0 | Real OviedoReal Oviedo |
| 30 Jul 22 | r03 | PerugiaPerugia | 2 - 0 | RiminiRimini |
| 30 Jul 22 | r03 | VitesseVitesse | 1 - 2 | AtromitosAtromitos |
| 30 Jul 22 | r03 | MVV MaastrichtMVV Maastrich | - | StandardStandard |
| 30 Jul 22 | r03 | MafraMafra | 2 - 0 | Vitoria SetubalVitoria Setub |
| 30 Jul 22 | r03 | LarneLarne | 7 - 2 | ArdsArds |
| 30 Jul 22 | r03 | Sporting CPSporting CP | 1 - 1 | WolvesWolves |
| 30 Jul 22 | r03 | Nottingham ForestNottingham Fo | 1 - 1 | ValenciaValencia |
| 30 Jul 22 | r03 | Sp GijonSp Gijon | 1 - 1 | PonferradinaPonferradina |
| 30 Jul 22 | r03 | GranadaGranada | 3 - 2 | AlmeriaAlmeria |
| 30 Jul 22 | r03 | BurgosBurgos | 2 - 1 | SantanderSantander |
| 30 Jul 22 | r03 | MurciaMurcia | 3 - 1 | Villarreal BVillarreal B |
| 30 Jul 22 | r03 | SC HeerenveenSC Heerenveen | 3 - 1 | ExcelsiorExcelsior |
| 30 Jul 22 | r03 | CovilhaCovilha | 2 - 2 | Associação Académica de CAssociação Ac |
| 30 Jul 22 | r03 | Rio AveRio Ave | 1 - 0 | Academico ViseuAcademico Vis |
| 30 Jul 22 | r03 | LevanteLevante | 4 - 0 | CastellónCastellón |
| 30 Jul 22 | r03 | MaritimoMaritimo | 1 - 0 | CD Nacional de MadeiraCD Nacional d |
| 30 Jul 22 | r03 | F.C. Paços de FerreiraF.C. Paços de | 1 - 2 | VizelaVizela |
| 30 Jul 22 | r03 | NAC BredaNAC Breda | 2 - 1 | VirtonVirton |
| 30 Jul 22 | r03 | LeganesLeganes | 0 - 0 | AlbaceteAlbacete |
| 30 Jul 22 | r03 | Cartagena FCCartagena FC | 2 - 0 | ElcheElche |
| 30 Jul 22 | r03 | TrofenseTrofense | 1 - 2 | BoavistaBoavista |
| 30 Jul 22 | r03 | AngersAngers | 2 - 2 | SpeziaSpezia |
| 30 Jul 22 | r03 | Xerez DeportivoXerez Deporti | 1 - 2 | MalagaMalaga |
| 31 Jul 22 | r03 | Stade de ReimsStade de Reim | 2 - 2 | SassuoloSassuolo |
| 31 Jul 22 | r03 | CremoneseCremonese | 3 - 1 | A.C. Crema 1908A.C. Crema 19 |
| 31 Jul 22 | r03 | CosenzaCosenza | 1 - 1 | Virtus FrancavillaVirtus Franca |
| 31 Jul 22 | r03 | WolfsburgWolfsburg | 3 - 1 | Hessen KasselHessen Kassel |
| 31 Jul 22 | r03 | Almere City FCAlmere City F | - | Jong AjaxJong Ajax |
| 31 Jul 22 | r03 | FulhamFulham | 1 - 1 | VillarrealVillarreal |
| 31 Jul 22 | r03 | CittadellaCittadella | 2 - 1 | Luparense F.C.Luparense F.C |
| 31 Jul 22 | r03 | L.R. Vicenza VirtusL.R. Vicenza | 3 - 1 | ASD CartiglianoASD Cartiglia |
| 31 Jul 22 | r03 | MonzaMonza | 3 - 2 | Sangiuliano CitySangiuliano C |
| 31 Jul 22 | r03 | LevadeiakosLevadeiakos | 2 - 1 | IonikosIonikos |
| 31 Jul 22 | r03 | CD Nacional de MadeiraCD Nacional d | 1 - 2 | Santa ClaraSanta Clara |
| 31 Jul 22 | r03 | SC FarenseSC Farense | 1 - 1 | WolvesWolves |
| 31 Jul 22 | r03 | LeicesterLeicester | 1 - 0 | SevillaSevilla |
| 31 Jul 22 | r03 | LeedsLeeds | 6 - 2 | CagliariCagliari |
| 31 Jul 22 | r03 | ZaragozaZaragoza | 2 - 1 | Al ShababAl Shabab |
| 31 Jul 22 | r03 | UD IbizaUD Ibiza | 0 - 1 | TenerifeTenerife |
| 31 Jul 22 | r03 | ChavesChaves | 0 - 0 | LugoLugo |
| 31 Jul 22 | r03 | MirandesMirandes | 0 - 3 | Ath BilbaoAth Bilbao |
| 31 Jul 22 | r03 | NapoliNapoli | 1 - 1 | MallorcaMallorca |
| 31 Jul 22 | r03 | Estrela AmadoraEstrela Amado | 3 - 0 | Atlético PetróleosAtlético Petr |
| 01 Aug 22 | r03 | AtromitosAtromitos | - | Al-TaawonAl-Taawon |
| 01 Aug 22 | r03 | Genk IIGenk II | 5 - 1 | Jong AZJong AZ |
| 02 Aug 22 | r03 | Armagh CityArmagh City | 0 - 1 | GlenavonGlenavon |
| 02 Aug 22 | r03 | ElcheElche | 0 - 1 | UD IbizaUD Ibiza |
| 02 Aug 22 | r03 | BeltinciBeltinci | 0 - 3 | SC Dnipro-1SC Dnipro-1 |
| 02 Aug 22 | r03 | Banbridge TownBanbridge Tow | 2 - 6 | Newry City AFCNewry City AF |
| 02 Aug 22 | r03 | LoughgallLoughgall | 3 - 0 | PortadownPortadown |
| 02 Aug 22 | r03 | Ballymacash RangersBallymacash R | 0 - 3 | Ballymena UnitedBallymena Uni |
| 03 Aug 22 | r03 | CittadellaCittadella | - | Virtus VeronaVirtus Verona |
| 03 Aug 22 | r03 | Niki VolouNiki Volou | - | LamiaLamia |
| 03 Aug 22 | r03 | MafraMafra | - | AlvercaAlverca |
| 03 Aug 22 | r03 | EibarEibar | 2 - 1 | UD LogroñésUD Logroñés |
| 03 Aug 22 | r03 | Al WahdaAl Wahda | 0 - 4 | Pafos FCPafos FC |
| 03 Aug 22 | r03 | Radomiak RadomRadomiak Rado | 0 - 0 | Anorthosis FamagustaAnorthosis Fa |
| 03 Aug 22 | r03 | VeneziaVenezia | 0 - 1 | CesenaCesena |
| 03 Aug 22 | r03 | MurciaMurcia | 3 - 0 | TenerifeTenerife |
| 03 Aug 22 | r03 | Enosis Neon ParalimniEnosis Neon P | 1 - 0 | Doxa KatokopiasDoxa Katokopi |
| 03 Aug 22 | r03 | Napredak KruševacNapredak Kruš | 3 - 1 | Timok ZaječarTimok Zaječar |
| 03 Aug 22 | r03 | NapoliNapoli | 3 - 1 | GironaGirona |
| 03 Aug 22 | r03 | AlavesAlaves | 1 - 1 | Sp GijonSp Gijon |
| 03 Aug 22 | r03 | La CorunaLa Coruna | 7 - 1 | PonferradinaPonferradina |
| 03 Aug 22 | r03 | BetisBetis | 2 - 2 | ZaragozaZaragoza |
| 03 Aug 22 | r03 | VillarrealVillarreal | 3 - 1 | LevanteLevante |
| 03 Aug 22 | r03 | Real AvilésReal Avilés | 1 - 2 | Real OviedoReal Oviedo |
| 03 Aug 22 | r03 | DollingstownDollingstown | 6 - 1 | PortadownPortadown |
| 03 Aug 22 | r03 | NumanciaNumancia | 1 - 2 | SantanderSantander |
| 03 Aug 22 | r03 | AlcorconAlcorcon | 1 - 2 | LeganesLeganes |
| 03 Aug 22 | r03 | GimnasticGimnastic | 2 - 2 | HuescaHuesca |
| 03 Aug 22 | r03 | Ballyclare ComradesBallyclare Co | 2 - 1 | GlenavonGlenavon |
| 03 Aug 22 | r03 | CastellónCastellón | 1 - 0 | ValenciaValencia |
| 03 Aug 22 | r03 | BoavistaBoavista | 3 - 3 | BolivarBolivar |
| 03 Aug 22 | r03 | CordobaCordoba | 1 - 1 | Villarreal BVillarreal B |
| 03 Aug 22 | r03 | CD GuadalajaraCD Guadalajar | - | L.A. GalaxyL.A. Galaxy |
| 04 Aug 22 | r03 | SassuoloSassuolo | 4 - 1 | Vis PesaroVis Pesaro |
| 04 Aug 22 | r03 | EldenseEldense | 1 - 1 | AlbaceteAlbacete |
| 05 Aug 22 | r03 | VallecanoVallecano | 0 - 0 | ValladolidValladolid |
| 05 Aug 22 | r03 | SociedadSociedad | 1 - 2 | EibarEibar |
| 05 Aug 22 | r03 | OsasunaOsasuna | 1 - 0 | BurgosBurgos |
| 05 Aug 22 | r03 | Doxa KatokopiasDoxa Katokopi | - | AEL LimassolAEL Limassol |
| 05 Aug 22 | r03 | Omonia NicosiaOmonia Nicosi | 0 - 2 | AEKAEK |
| 05 Aug 22 | r03 | HuescaHuesca | 3 - 1 | FC AndorraFC Andorra |
| 05 Aug 22 | r03 | MirandesMirandes | 1 - 2 | OsasunaOsasuna |
| 05 Aug 22 | r03 | AlmeriaAlmeria | 1 - 0 | Cartagena FCCartagena FC |
| 05 Aug 22 | r03 | Ath BilbaoAth Bilbao | 1 - 0 | SociedadSociedad |
| 06 Aug 22 | r03 | VirtonVirton | - | Al Fateh FCAl Fateh FC |
| 06 Aug 22 | r03 | FC Kolos KovalivkaFC Kolos Kova | 0 - 1 | Veres RivneVeres Rivne |
| 06 Aug 22 | r03 | Ath BilbaoAth Bilbao | 1 - 1 | AlavesAlaves |
| 06 Aug 22 | r03 | MarinoMarino | 0 - 1 | Sp GijonSp Gijon |
| 06 Aug 22 | r03 | Las PalmasLas Palmas | 3 - 0 | TamaraceiteTamaraceite |
| 06 Aug 22 | r03 | GlenavonGlenavon | 2 - 1 | Annagh UnitedAnnagh United |
| 06 Aug 22 | r03 | H and W WeldersH and W Welde | 0 - 1 | PortadownPortadown |
| 06 Aug 22 | r03 | Ballinamallard UnitedBallinamallar | 2 - 2 | Dungannon SwiftsDungannon Swi |
| 06 Aug 22 | r03 | GlentoranGlentoran | 2 - 1 | LoughgallLoughgall |
| 06 Aug 22 | r03 | Newry City AFCNewry City AF | 2 - 1 | DundelaDundela |
| 06 Aug 22 | r03 | ColeraineColeraine | 4 - 1 | ArdsArds |
| 06 Aug 22 | r03 | Warrenpoint TownWarrenpoint T | 1 - 0 | Carrick RangersCarrick Range |
| 06 Aug 22 | r03 | LarneLarne | 0 - 3 | BangorBangor |
| 06 Aug 22 | r03 | Ballymena UnitedBallymena Uni | 2 - 0 | CliftonvilleCliftonville |
| 06 Aug 22 | r03 | SudtirolSudtirol | 2 - 2 | MantovaMantova |
| 06 Aug 22 | r03 | Omonia NicosiaOmonia Nicosi | 3 - 0 | MEAP NisouMEAP Nisou |
| 06 Aug 22 | r03 | LugoLugo | 1 - 0 | Racing Club de FerrolRacing Club d |
| 06 Aug 22 | r03 | BSK Bijelo BrdoBSK Bijelo Br | 5 - 0 | Osijek IIOsijek II |
| 06 Aug 22 | r03 | Botev PlovdivBotev Plovdiv | 2 - 1 | Nea Salamis FamagustaNea Salamis F |
| 06 Aug 22 | r03 | SC Dnipro-1SC Dnipro-1 | 1 - 1 | Al SharjahAl Sharjah |
| 06 Aug 22 | r03 | LamiaLamia | 2 - 0 | LevadeiakosLevadeiakos |
| 06 Aug 22 | r03 | NapoliNapoli | 0 - 0 | EspanolEspanol |
| 06 Aug 22 | r03 | Lommel SKLommel SK | - | GentGent |
| 06 Aug 22 | r03 | SantanderSantander | 0 - 0 | Real OviedoReal Oviedo |
| 06 Aug 22 | r03 | Cartagena FCCartagena FC | 1 - 1 | TenerifeTenerife |
| 06 Aug 22 | r03 | Real AvilésReal Avilés | 0 - 1 | Sp GijonSp Gijon |
| 06 Aug 22 | r03 | ValladolidValladolid | 0 - 0 | LazioLazio |
| 06 Aug 22 | r03 | GranadaGranada | 1 - 1 | MalagaMalaga |
| 06 Aug 22 | r03 | ValenciaValencia | 2 - 1 | AtalantaAtalanta |
| 06 Aug 22 | r03 | BetisBetis | 3 - 1 | FiorentinaFiorentina |
| 06 Aug 22 | r03 | GironaGirona | 2 - 0 | BolivarBolivar |
| 06 Aug 22 | r03 | SevillaSevilla | 1 - 0 | CadizCadiz |
| 06 Aug 22 | r03 | LeganesLeganes | 1 - 2 | Villarreal BVillarreal B |
| 07 Aug 22 | r03 | Alki OrokliniAlki Oroklini | - | Olympiakos NicosiaOlympiakos Ni |
| 07 Aug 22 | r03 | Asteras TripolisAsteras Tripo | 0 - 1 | OFIOFI |
| 07 Aug 22 | r03 | TorviscosaTorviscosa | 1 - 3 | Pordenone CalcioPordenone Cal |
| 07 Aug 22 | r03 | Lleida EsportiuLleida Esport | - | ZaragozaZaragoza |
| 07 Aug 22 | r03 | IonikosIonikos | 2 - 2 | AtromitosAtromitos |
| 07 Aug 22 | r03 | GironaGirona | 1 - 1 | ZaragozaZaragoza |
| 07 Aug 22 | r03 | NFC VolosNFC Volos | 2 - 0 | GianninaGiannina |
| 07 Aug 22 | r03 | AlbaceteAlbacete | 1 - 0 | GetafeGetafe |
| 07 Aug 22 | r03 | CrotoneCrotone | 4 - 1 | Lamezia TermeLamezia Terme |
| 07 Aug 22 | r03 | UD IbizaUD Ibiza | 0 - 0 | MallorcaMallorca |
| 08 Aug 22 | r03 | AlbaceteAlbacete | 1 - 0 | SocuéllamosSocuéllamos |
| 09 Aug 22 | r03 | FC LvivFC Lviv | 0 - 0 | KarpatyKarpaty |
| 09 Aug 22 | r03 | Union BerlinUnion Berlin | 1 - 1 | HannoverHannover |
| 09 Aug 22 | r03 | Spartak PlevenSpartak Pleve | 1 - 3 | AEL LimassolAEL Limassol |
| 09 Aug 22 | r03 | Asteras TripolisAsteras Tripo | 2 - 2 | GianninaGiannina |
| 09 Aug 22 | r03 | KarmiotissaKarmiotissa | 2 - 1 | Doxa KatokopiasDoxa Katokopi |
| 09 Aug 22 | r03 | NFC VolosNFC Volos | 2 - 1 | OFIOFI |
| 10 Aug 22 | r03 | Shakhtar DonetskShakhtar Done | 1 - 0 | Al-AdalahAl-Adalah |
| 10 Aug 22 | r03 | Tabor SežanaTabor Sežana | 0 - 2 | Al Fateh FCAl Fateh FC |
| 10 Aug 22 | r03 | Ethnikos AchnaEthnikos Achn | 1 - 0 | Enosis Neon ParalimniEnosis Neon P |
| 10 Aug 22 | r03 | FeralpisalòFeralpisalò | 1 - 2 | EntellaEntella |
| 10 Aug 22 | r03 | GubbioGubbio | 1 - 0 | S.C. Trestina A.S.D.S.C. Trestina |
| 10 Aug 22 | r03 | NK VaraždinNK Varaždin | 3 - 3 | SC Dnipro-1SC Dnipro-1 |
| 10 Aug 22 | r03 | PanachaikiPanachaiki | 1 - 2 | AtromitosAtromitos |
| 10 Aug 22 | r03 | Anorthosis FamagustaAnorthosis Fa | 0 - 0 | Doxa KatokopiasDoxa Katokopi |
| 10 Aug 22 | r03 | DomzaleDomzale | 0 - 3 | Shakhtar DonetskShakhtar Done |
| 10 Aug 22 | r03 | DollingstownDollingstown | 0 - 2 | GlenavonGlenavon |
| 12 Aug 22 | r03 | LamiaLamia | - | Anagennisi KarditsasAnagennisi Ka |
| 12 Aug 22 | r03 | Aris LimassolAris Limassol | 5 - 0 | XylotymbouXylotymbou |
| 12 Aug 22 | r03 | GianninaGiannina | 2 - 2 | KarmiotissaKarmiotissa |
| 13 Aug 22 | r03 | NFC VolosNFC Volos | - | AEKAEK |
| 13 Aug 22 | r03 | De TreffersDe Treffers | 1 - 2 | De GraafschapDe Graafschap |
| 13 Aug 22 | r03 | Veres RivneVeres Rivne | 2 - 0 | Rukh LvivRukh Lviv |
| 13 Aug 22 | r03 | LevadeiakosLevadeiakos | 1 - 1 | AtromitosAtromitos |
| 13 Aug 22 | r03 | Akritas ChlorakasAkritas Chlor | 4 - 1 | Aris LimassolAris Limassol |
| 13 Aug 22 | r03 | LamiaLamia | 1 - 0 | IonikosIonikos |
| 13 Aug 22 | r03 | Enosis Neon ParalimniEnosis Neon P | 1 - 1 | Olympiakos NicosiaOlympiakos Ni |
| 13 Aug 22 | r03 | OFIOFI | 4 - 0 | EpiskopiEpiskopi |
| 13 Aug 22 | r03 | Pafos FCPafos FC | 1 - 0 | Doxa KatokopiasDoxa Katokopi |
| 13 Aug 22 | r03 | Nea Salamis FamagustaNea Salamis F | 0 - 2 | Anorthosis FamagustaAnorthosis Fa |
| 13 Aug 22 | r03 | La CorunaLa Coruna | 4 - 2 | Metalist KharkivMetalist Khar |
| 15 Aug 22 | r03 | Shakhtar DonetskShakhtar Done | 5 - 0 | Al Fateh FCAl Fateh FC |
| 16 Aug 22 | r03 | BrühlBrühl | 2 - 4 | St. GallenSt. Gallen |
| 16 Aug 22 | r03 | HuescaHuesca | 1 - 0 | SabadellSabadell |
| 17 Aug 22 | r03 | Septemvri SofiaSeptemvri Sof | 0 - 4 | AEL LimassolAEL Limassol |
| 19 Aug 22 | r03 | Nea Salamis FamagustaNea Salamis F | 1 - 2 | Olympiakos NicosiaOlympiakos Ni |
| 20 Aug 22 | r03 | Aris LimassolAris Limassol | 0 - 2 | Anagennisi DeryneiaAnagennisi De |
| 20 Aug 22 | r03 | AEZAEZ | 0 - 1 | AEL LimassolAEL Limassol |
| 20 Aug 22 | r03 | Akritas ChlorakasAkritas Chlor | 3 - 0 | ASILASIL |
| 20 Aug 22 | r03 | Anorthosis FamagustaAnorthosis Fa | 3 - 4 | Pafos FCPafos FC |
| 20 Aug 22 | r03 | Doxa KatokopiasDoxa Katokopi | 2 - 0 | Omonia 29is MaiouOmonia 29is M |
| 21 Aug 22 | r03 | PeyiaPeyia | 0 - 4 | Pafos FCPafos FC |
| 09 Sep 22 | r03 | Al HilalAl Hilal | 1 - 1 | Zamalek SCZamalek SC |
| 18 Sep 22 | r03 | FC LvivFC Lviv | 0 - 1 | Veres RivneVeres Rivne |
| 20 Sep 22 | r03 | MynaiMynai | 2 - 1 | Metalist KharkivMetalist Khar |
| 21 Sep 22 | r03 | Mgladbach IIMgladbach II | 2 - 0 | Standard IIStandard II |
| 21 Sep 22 | r03 | KarlsruheKarlsruhe | 4 - 0 | FC WinterthurFC Winterthur |
| 21 Sep 22 | r03 | ZoryaZorya | 1 - 1 | FC OlexandriaFC Olexandria |
| 21 Sep 22 | r03 | SC VerlSC Verl | 0 - 3 | WiedenbrückWiedenbrück |
| 21 Sep 22 | r03 | Odense BKOdense BK | - | MarienlystMarienlyst |
| 22 Sep 22 | r03 | Wisla PlockWisla Plock | 5 - 0 | LKS LodzLKS Lodz |
| 22 Sep 22 | r03 | BordeauxBordeaux | 2 - 3 | Clermont FootClermont Foot |
| 22 Sep 22 | r03 | FuenlabradaFuenlabrada | 1 - 0 | VallecanoVallecano |
| 22 Sep 22 | r03 | NashvilleNashville | 3 - 3 | CF AmericaCF America |
| 22 Sep 22 | r03 | SC Rheindorf AltachSC Rheindorf | 2 - 0 | DornbirnDornbirn |
| 22 Sep 22 | r03 | ValladolidValladolid | 0 - 2 | OsasunaOsasuna |
| 22 Sep 22 | r03 | Wehen WiesbadenWehen Wiesbad | 4 - 4 | DarmstadtDarmstadt |
| 22 Sep 22 | r03 | WolfsburgWolfsburg | 0 - 0 | Hansa RostockHansa Rostock |
| 22 Sep 22 | r03 | NurnbergNurnberg | 4 - 3 | St. GallenSt. Gallen |
| 22 Sep 22 | r03 | HammarbyHammarby | 3 - 1 | Vaesteraas SKVaesteraas SK |
| 22 Sep 22 | r03 | Dortmund IIDortmund II | 2 - 4 | Go Ahead EaglesGo Ahead Eagl |
| 22 Sep 22 | r03 | MainzMainz | 2 - 5 | KarlsruheKarlsruhe |
| 22 Sep 22 | r03 | IngolstadtIngolstadt | 2 - 1 | SpVgg BayreuthSpVgg Bayreut |
| 22 Sep 22 | r03 | StuttgartStuttgart | 2 - 1 | GrasshoppersGrasshoppers |
| 22 Sep 22 | r03 | FC Trenkwalder AdmiraFC Trenkwalde | 2 - 1 | Szombathelyi HaladásSzombathelyi |
| 22 Sep 22 | r03 | Legia WarsawLegia Warsaw | 3 - 0 | Stal RzeszówStal Rzeszów |
| 22 Sep 22 | r03 | SC VerlSC Verl | 2 - 0 | Lippstadt 08Lippstadt 08 |
| 22 Sep 22 | r03 | AugsburgAugsburg | 5 - 2 | Austria LustenauAustria Luste |
| 22 Sep 22 | r03 | WSG Swarovski TirolWSG Swarovski | 0 - 1 | Munich 1860Munich 1860 |
| 22 Sep 22 | r03 | FK PirmasensFK Pirmasens | 1 - 4 | KaiserslauternKaiserslauter |
| 23 Sep 22 | r03 | Mlada BoleslavMlada Bolesla | 3 - 0 | TáborskoTáborsko |
| 23 Sep 22 | r03 | FC VitebskFC Vitebsk | 1 - 2 | Naftan NovopolotskNaftan Novopo |
| 23 Sep 22 | r03 | Tabor SežanaTabor Sežana | 2 - 1 | GoricaGorica |
| 23 Sep 22 | r03 | AmiensAmiens | 2 - 5 | QuevillyQuevilly |
| 23 Sep 22 | r03 | Botev Plovdiv IIBotev Plovdiv | 0 - 2 | BeroeBeroe |
| 23 Sep 22 | r03 | SiófokSiófok | 2 - 3 | Paksi FCPaksi FC |
| 23 Sep 22 | r03 | Napredak KruševacNapredak Kruš | 3 - 0 | Arsenal TivatArsenal Tivat |
| 23 Sep 22 | r03 | RosenborgRosenborg | 2 - 1 | RanheimRanheim |
| 23 Sep 22 | r03 | Rakow CzestochowaRakow Czestoc | 6 - 0 | Gornik ZabrzeGornik Zabrze |
| 23 Sep 22 | r03 | HNK GoricaHNK Gorica | 3 - 2 | DomzaleDomzale |
| 23 Sep 22 | r03 | LASKLASK | 9 - 2 | SKU AmstettenSKU Amstetten |
| 23 Sep 22 | r03 | Schalke 04 IISchalke 04 II | 2 - 2 | Jong AZJong AZ |
| 23 Sep 22 | r03 | Mezőkövesdi SEMezőkövesdi S | 0 - 0 | KazincbarcikaKazincbarcika |
| 23 Sep 22 | r03 | Sturm GrazSturm Graz | 5 - 1 | NK MariborNK Maribor |
| 23 Sep 22 | r03 | TSV HartbergTSV Hartberg | 1 - 0 | First ViennaFirst Vienna |
| 23 Sep 22 | r03 | Aris LimassolAris Limassol | 7 - 1 | AEZAEZ |
| 23 Sep 22 | r03 | SAK KlagenfurtSAK Klagenfur | 6 - 2 | Grazer AKGrazer AK |
| 23 Sep 22 | r03 | LucerneLucerne | 6 - 0 | FC AarauFC Aarau |
| 23 Sep 22 | r03 | Nea Salamis FamagustaNea Salamis F | 1 - 2 | KarmiotissaKarmiotissa |
| 23 Sep 22 | r03 | Philadelphia UnionPhiladelphia | 1 - 0 | PachucaPachuca |
| 24 Sep 22 | r03 | Isloch Minsk RaionIsloch Minsk | 2 - 1 | FC OstrovetsFC Ostrovets |
| 24 Sep 22 | r03 | Dinamo MinskDinamo Minsk | 0 - 0 | FK Arsenal DzerzhinskFK Arsenal Dz |
| 24 Sep 22 | r03 | Odra OpoleOdra Opole | 0 - 2 | Podbeskidzie Bielsko-BialPodbeskidzie |
| 24 Sep 22 | r03 | CukarickiCukaricki | 3 - 0 | Arsenal TivatArsenal Tivat |
| 24 Sep 22 | r03 | FC SmorgonFC Smorgon | 0 - 1 | Energetik-BGU MinskEnergetik-BGU |
| 24 Sep 22 | r03 | Lokomotiv GomelLokomotiv Gom | 2 - 3 | Slavia MozyrSlavia Mozyr |
| 24 Sep 22 | r03 | Slask WroclawSlask Wroclaw | - | Odra OpoleOdra Opole |
| 24 Sep 22 | r03 | Pogon SzczecinPogon Szczeci | 3 - 1 | Warta PoznańWarta Poznań |
| 24 Sep 22 | r03 | Korona KielceKorona Kielce | 1 - 1 | Skra CzęstochowaSkra Częstoch |
| 24 Sep 22 | r03 | Hebar PazardzhikHebar Pazardz | 1 - 1 | Slavia SofiaSlavia Sofia |
| 24 Sep 22 | r03 | OsijekOsijek | 2 - 3 | Siroki BrijegSiroki Brijeg |
| 24 Sep 22 | r03 | VasasVasas | 0 - 0 | KozármislenyKozármisleny |
| 24 Sep 22 | r03 | FC SaarbrückenFC Saarbrücke | 3 - 1 | DürenDüren |
| 24 Sep 22 | r03 | BochumBochum | - | Fortuna DüsseldorfFortuna Düsse |
| 24 Sep 22 | r03 | Lokomotiv PlovdivLokomotiv Plo | 1 - 0 | Arda KardzhaliArda Kardzhal |
| 24 Sep 22 | r03 | Pirin BlagoevgradPirin Blagoev | 0 - 1 | Bregalnica ŠtipBregalnica Št |
| 24 Sep 22 | r03 | RijekaRijeka | 4 - 0 | CeljeCelje |
| 24 Sep 22 | r03 | CSKA 1948CSKA 1948 | 1 - 1 | Botev VratsaBotev Vratsa |
| 24 Sep 22 | r03 | Kispest HonvedKispest Honve | 1 - 2 | TSC Bačka TopolaTSC Bačka Top |
| 24 Sep 22 | r03 | Botev PlovdivBotev Plovdiv | 7 - 0 | Maritsa PlovdivMaritsa Plovd |
| 24 Sep 22 | r03 | VukovarVukovar | 2 - 3 | Slaven Belupo KoprivnicaSlaven Belupo |
| 24 Sep 22 | r03 | Radomiak RadomRadomiak Rado | 2 - 0 | Shakhtar DonetskShakhtar Done |
| 24 Sep 22 | r03 | AE LarissaAE Larissa | 1 - 0 | NFC VolosNFC Volos |
| 24 Sep 22 | r03 | CSKA SofiaCSKA Sofia | 2 - 0 | Septemvri SofiaSeptemvri Sof |
| 24 Sep 22 | r03 | FC DallasFC Dallas | 0 - 3 | TigresTigres |
| 25 Sep 22 | r03 | ZoryaZorya | 0 - 1 | FC Kolos KovalivkaFC Kolos Kova |
| 25 Sep 22 | r03 | VukovarVukovar | 0 - 1 | OsijekOsijek |
| 25 Sep 22 | r03 | Dynamo BrestDynamo Brest | 0 - 3 | Neman GrodnoNeman Grodno |
| 25 Sep 22 | r03 | Siroki BrijegSiroki Brijeg | 0 - 0 | Slaven Belupo KoprivnicaSlaven Belupo |
| 25 Sep 22 | r03 | FC MinskFC Minsk | 5 - 0 | FC OsipovichiFC Osipovichi |
| 25 Sep 22 | r03 | Shakhter SoligorskShakhter Soli | 5 - 2 | FC Belshina BobruiskFC Belshina B |
| 25 Sep 22 | r03 | VeronaVerona | 0 - 0 | KoperKoper |
| 25 Sep 22 | r03 | CD GuadalajaraCD Guadalajar | 1 - 3 | CF AmericaCF America |
| 27 Sep 22 | r03 | Levski SofiaLevski Sofia | 1 - 1 | Sportist SvogeSportist Svog |
| 19 Oct 22 | r03 | Schalke 04 IISchalke 04 II | 0 - 5 | Jong PSVJong PSV |
| 01 Nov 22 | r03 | Jong UtrechtJong Utrecht | 2 - 1 | Jong SpartaJong Sparta |
| 08 Nov 22 | r03 | Jong UtrechtJong Utrecht | 1 - 1 | ExcelsiorExcelsior |
| 11 Nov 22 | r03 | HackenHacken | 1 - 2 | Utsiktens BKUtsiktens BK |
| 15 Nov 22 | r03 | Wiener NeustadtWiener Neusta | 0 - 4 | Sturm Graz IISturm Graz II |
| 16 Nov 22 | r03 | Orange County SCOrange County | 0 - 1 | HamburgHamburg |
| 16 Nov 22 | r03 | Urawa Red DiamondsUrawa Red Dia | 4 - 2 | Ein FrankfurtEin Frankfurt |
| 16 Nov 22 | r03 | PoblensePoblense | 1 - 4 | MallorcaMallorca |
| 16 Nov 22 | r03 | Colo-ColoColo-Colo | 5 - 0 | BetisBetis |
| 17 Nov 22 | r03 | LinenseLinense | 1 - 1 | HammarbyHammarby |
| 17 Nov 22 | r03 | St. Louis City SC 2St. Louis Cit | 0 - 3 | LeverkusenLeverkusen |
| 17 Nov 22 | r03 | Odense BKOdense BK | 3 - 2 | NykøbingNykøbing |
| 17 Nov 22 | r03 | SiriusSirius | 2 - 2 | AIKAIK |
| 17 Nov 22 | r03 | Randers FCRanders FC | 2 - 2 | Malmo FFMalmo FF |
| 17 Nov 22 | r03 | Utsiktens BKUtsiktens BK | 1 - 3 | OddevoldOddevold |
| 18 Nov 22 | r03 | SC Rheindorf AltachSC Rheindorf | 5 - 0 | DornbirnDornbirn |
| 18 Nov 22 | r03 | LavalLaval | 1 - 0 | Stade BriochinStade Briochi |
| 18 Nov 22 | r03 | Red StarRed Star | 2 - 1 | QuevillyQuevilly |
| 18 Nov 22 | r03 | TSV HartbergTSV Hartberg | 1 - 3 | Floridsdorfer ACFloridsdorfer |
| 18 Nov 22 | r03 | Zaglebie SosnowiecZaglebie Sosn | 0 - 3 | Podbeskidzie Bielsko-BialPodbeskidzie |
| 18 Nov 22 | r03 | Cracovia KrakowCracovia Krak | 3 - 4 | FK Železiarne PodbrezováFK Železiarne |
| 18 Nov 22 | r03 | Gornik LecznaGornik Leczna | 2 - 0 | Polonia WarsawPolonia Warsa |
| 18 Nov 22 | r03 | NiecieczaNieciecza | 2 - 0 | Stal RzeszówStal Rzeszów |
| 18 Nov 22 | r03 | Stal MielecStal Mielec | 1 - 1 | Wisla KrakowWisla Krakow |
| 18 Nov 22 | r03 | BeroeBeroe | 1 - 1 | Yantra GabrovoYantra Gabrov |
| 18 Nov 22 | r03 | DomzaleDomzale | 2 - 3 | Sturm GrazSturm Graz |
| 18 Nov 22 | r03 | Považská BystricaPovažská Byst | 1 - 3 | SFC OpavaSFC Opava |
| 18 Nov 22 | r03 | KoperKoper | 2 - 1 | NK BravoNK Bravo |
| 18 Nov 22 | r03 | Austria Vienna (Am)Austria Vienn | 0 - 4 | Lask Juniors LinzLask Juniors |
| 18 Nov 22 | r03 | SV KapfenbergSV Kapfenberg | 2 - 2 | TSV HartbergTSV Hartberg |
| 19 Nov 22 | r03 | NorrkopingNorrkoping | 2 - 1 | OskarshamnsOskarshamns |
| 19 Nov 22 | r03 | Ventura County FusionVentura Count | 0 - 7 | HamburgHamburg |
| 19 Nov 22 | r03 | Gamba OsakaGamba Osaka | 2 - 1 | Ein FrankfurtEin Frankfurt |
| 19 Nov 22 | r03 | FC SlutskFC Slutsk | 0 - 0 | Slavia MozyrSlavia Mozyr |
| 19 Nov 22 | r03 | Lokomotiv PlovdivLokomotiv Plo | 2 - 3 | CSKA 1948CSKA 1948 |
| 19 Nov 22 | r03 | Botev PlovdivBotev Plovdiv | 2 - 1 | Litex LovechLitex Lovech |
| 19 Nov 22 | r03 | SAK KlagenfurtSAK Klagenfur | 2 - 1 | Grazer AKGrazer AK |
| 19 Nov 22 | r03 | HerthaHertha | 3 - 3 | Munich 1860Munich 1860 |
| 19 Nov 22 | r03 | Colo-ColoColo-Colo | 1 - 0 | BetisBetis |
| 19 Nov 22 | r03 | FC KolnFC Koln | 2 - 4 | StuttgartStuttgart |
| 20 Nov 22 | r03 | HerthaHertha | 1 - 1 | Grazer AKGrazer AK |
| 20 Nov 22 | r03 | Brașov Steagul RenașteBrașov Steagu | 0 - 1 | Rapid BucurestiRapid Bucures |
| 20 Nov 22 | r03 | CSKA SofiaCSKA Sofia | 6 - 0 | Minyor PernikMinyor Pernik |
| 20 Nov 22 | r03 | FC BaselFC Basel | 0 - 0 | SandhausenSandhausen |
| 20 Nov 22 | r03 | Uta AradUta Arad | 2 - 1 | VojvodinaVojvodina |
| 20 Nov 22 | r03 | SAK KlagenfurtSAK Klagenfur | 2 - 1 | Munich 1860Munich 1860 |
| 22 Nov 22 | r03 | AGF AarhusAGF Aarhus | 1 - 1 | HackenHacken |
| 22 Nov 22 | r03 | Juventud TorremolinosJuventud Torr | 0 - 3 | HammarbyHammarby |
| 22 Nov 22 | r03 | Zenit St PetersburgZenit St Pete | 3 - 1 | Crvena ZvezdaCrvena Zvezda |
| 23 Nov 22 | r03 | RadomljeRadomlje | 3 - 0 | Tabor SežanaTabor Sežana |
| 23 Nov 22 | r03 | Sepsi OSK Sfântu GheorgheSepsi OSK Sfâ | 2 - 2 | PetrolulPetrolul |
| 23 Nov 22 | r03 | Universitatea ClujUniversitatea | 2 - 1 | FC HermannstadtFC Hermannsta |
| 23 Nov 22 | r03 | FC NordsjællandFC Nordsjælla | 1 - 2 | Odense BKOdense BK |
| 23 Nov 22 | r03 | Odd BallklubbOdd Ballklubb | 3 - 0 | MjoendalenMjoendalen |
| 23 Nov 22 | r03 | Wolfsberger ACWolfsberger A | 1 - 2 | CeljeCelje |
| 24 Nov 22 | r03 | KøgeKøge | 4 - 1 | Fremad AmagerFremad Amager |
| 24 Nov 22 | r03 | NŠ MuraNŠ Mura | 2 - 2 | NK BravoNK Bravo |
| 24 Nov 22 | r03 | AIKAIK | 1 - 1 | Vaesteraas SKVaesteraas SK |
| 24 Nov 22 | r03 | SV KapfenbergSV Kapfenberg | 2 - 0 | MauerwerkMauerwerk |
| 24 Nov 22 | r03 | AntequeraAntequera | 1 - 2 | HammarbyHammarby |
| 24 Nov 22 | r03 | Austria LustenauAustria Luste | 4 - 3 | WSG Swarovski TirolWSG Swarovski |
| 24 Nov 22 | r03 | NorrkopingNorrkoping | 1 - 0 | Motala AIFMotala AIF |
| 25 Nov 22 | r03 | FK Železiarne PodbrezováFK Železiarne | 1 - 3 | Wisla PlockWisla Plock |
| 25 Nov 22 | r03 | SandhausenSandhausen | 0 - 0 | SC Rheindorf AltachSC Rheindorf |
| 25 Nov 22 | r03 | Stal MielecStal Mielec | 1 - 0 | Stal RzeszówStal Rzeszów |
| 25 Nov 22 | r03 | LiberecLiberec | - | Dukla PrahaDukla Praha |
| 25 Nov 22 | r03 | Kolding IFKolding IF | 1 - 3 | FredericiaFredericia |
| 25 Nov 22 | r03 | Uta AradUta Arad | 2 - 0 | OFK VršacOFK Vršac |
| 25 Nov 22 | r03 | Gornik ZabrzeGornik Zabrze | 4 - 1 | Odra OpoleOdra Opole |
| 25 Nov 22 | r03 | Zaglebie SosnowiecZaglebie Sosn | 1 - 1 | Sandecja Nowy SaczSandecja Nowy |
| 25 Nov 22 | r03 | FC U Craiova 1948FC U Craiova | 0 - 1 | CS MioveniCS Mioveni |
| 25 Nov 22 | r03 | RasenBallsport LeipzigRasenBallspor | 6 - 0 | Radomiak RadomRadomiak Rado |
| 25 Nov 22 | r03 | Wisla KrakowWisla Krakow | - | Gornik LecznaGornik Leczna |
| 25 Nov 22 | r03 | First ViennaFirst Vienna | 1 - 2 | TSV HartbergTSV Hartberg |
| 25 Nov 22 | r03 | Al ShababAl Shabab | 0 - 1 | SunderlandSunderland |
| 25 Nov 22 | r03 | FC Trenkwalder AdmiraFC Trenkwalde | 0 - 4 | Sturm GrazSturm Graz |
| 25 Nov 22 | r03 | Lask Juniors LinzLask Juniors | 1 - 5 | FC BW LinzFC BW Linz |
| 25 Nov 22 | r03 | Rapid ViennaRapid Vienna | 2 - 2 | Floridsdorfer ACFloridsdorfer |
| 25 Nov 22 | r03 | Grazer AKGrazer AK | 5 - 1 | Wolfsberger AC IIWolfsberger A |
| 25 Nov 22 | r03 | Austria Vienna (Am)Austria Vienn | 2 - 2 | Donaufeld WienDonaufeld Wie |
| 25 Nov 22 | r03 | Rapid Wien IIRapid Wien II | 1 - 1 | SV Josko Ried IISV Josko Ried |
| 26 Nov 22 | r03 | FC VoluntariFC Voluntari | 0 - 0 | PetrolulPetrolul |
| 26 Nov 22 | r03 | Cracovia KrakowCracovia Krak | 1 - 0 | Dukla Banská BystricaDukla Banská |
| 26 Nov 22 | r03 | SKN St. PoltenSKN St. Polte | 7 - 1 | Dynamo České BudějoviceDynamo České |
| 26 Nov 22 | r03 | AGF AarhusAGF Aarhus | 0 - 1 | AC HorsensAC Horsens |
| 26 Nov 22 | r03 | HibernianHibernian | 0 - 2 | MiddlesbroughMiddlesbrough |
| 26 Nov 22 | r03 | MillwallMillwall | 1 - 1 | BrøndbyBrøndby |
| 28 Nov 22 | r03 | PAOKPAOK | 4 - 1 | FC AshdodFC Ashdod |
| 29 Nov 22 | r03 | KøgeKøge | 1 - 2 | B.93B.93 |
| 29 Nov 22 | r03 | Fortuna DüsseldorfFortuna Düsse | 3 - 0 | De GraafschapDe Graafschap |
| 29 Nov 22 | r03 | QPRQPR | 2 - 1 | LivingstonLivingston |
| 29 Nov 22 | r03 | Sturm Graz IISturm Graz II | 3 - 3 | GrafičarGrafičar |
| 30 Nov 22 | r03 | HOBROHOBRO | 1 - 1 | Skive IKSkive IK |
| 30 Nov 22 | r03 | CardiffCardiff | 3 - 1 | Aston VillaAston Villa |
| 30 Nov 22 | r03 | GetafeGetafe | 0 - 1 | ValladolidValladolid |
| 30 Nov 22 | r03 | XerezXerez | 0 - 0 | CadizCadiz |
| 01 Dec 22 | r03 | PanathinaikosPanathinaikos | 3 - 1 | Hapoel Beer ShevaHapoel Beer S |
| 01 Dec 22 | r03 | LyngbyLyngby | 1 - 2 | Odense BKOdense BK |
| 01 Dec 22 | r03 | AEL LimassolAEL Limassol | 0 - 3 | PAOKPAOK |
| 01 Dec 22 | r03 | FC BW LinzFC BW Linz | 3 - 4 | WSG Swarovski TirolWSG Swarovski |
| 01 Dec 22 | r03 | ArezzoArezzo | 1 - 4 | FiorentinaFiorentina |
| 01 Dec 22 | r03 | AGF AarhusAGF Aarhus | 0 - 1 | FredericiaFredericia |
| 01 Dec 22 | r03 | Huddersfield TownHuddersfield | 0 - 2 | OlympiakosOlympiakos |
| 01 Dec 22 | r03 | LyonLyon | 5 - 3 | Oud-Heverlee LeuvenOud-Heverlee |
| 02 Dec 22 | r03 | FC LieferingFC Liefering | 2 - 3 | GrafičarGrafičar |
| 02 Dec 22 | r03 | Gornik ZabrzeGornik Zabrze | 1 - 0 | Podbeskidzie Bielsko-BialPodbeskidzie |
| 02 Dec 22 | r03 | ElcheElche | 1 - 0 | West BromWest Brom |
| 02 Dec 22 | r03 | Ein FrankfurtEin Frankfurt | 5 - 1 | SandhausenSandhausen |
| 02 Dec 22 | r03 | LASKLASK | 2 - 1 | FC Trenkwalder AdmiraFC Trenkwalde |
| 02 Dec 22 | r03 | SV Josko RiedSV Josko Ried | 3 - 3 | Dynamo České BudějoviceDynamo České |
| 02 Dec 22 | r03 | RasenBallsport LeipzigRasenBallspor | 2 - 1 | AC HorsensAC Horsens |
| 02 Dec 22 | r03 | BraunschweigBraunschweig | - | SpVgg BayreuthSpVgg Bayreut |
| 02 Dec 22 | r03 | MSK ZilinaMSK Zilina | 3 - 0 | Považská BystricaPovažská Byst |
| 02 Dec 22 | r03 | GrasshoppersGrasshoppers | 4 - 1 | SC Rheindorf AltachSC Rheindorf |
| 02 Dec 22 | r03 | SKN St. PoltenSKN St. Polte | 1 - 1 | TSV HartbergTSV Hartberg |
| 02 Dec 22 | r03 | HannoverHannover | 1 - 2 | HerthaHertha |
| 02 Dec 22 | r03 | Rapid ViennaRapid Vienna | 4 - 1 | First ViennaFirst Vienna |
| 02 Dec 22 | r03 | MonacoMonaco | - | Cercle BruggeCercle Brugge |
| 02 Dec 22 | r03 | BlackburnBlackburn | 4 - 0 | HeartsHearts |
| 02 Dec 22 | r03 | Austria Vienna (Am)Austria Vienn | P - P | TraiskirchenTraiskirchen |
| 02 Dec 22 | r03 | Wolfsberger AC IIWolfsberger A | 1 - 5 | Sturm Graz IISturm Graz II |
| 02 Dec 22 | r03 | Wiener SCWiener SC | - | Floridsdorfer ACFloridsdorfer |
| 02 Dec 22 | r03 | StokeStoke | 2 - 1 | Nottingham ForestNottingham Fo |
| 03 Dec 22 | r03 | UdineseUdinese | 1 - 1 | Tabor SežanaTabor Sežana |
| 03 Dec 22 | r03 | Rapid Wien IIRapid Wien II | - | SKN St. PoltenSKN St. Polte |
| 03 Dec 22 | r03 | Cracovia KrakowCracovia Krak | 4 - 1 | Tatran Liptovský MikulášTatran Liptov |
| 03 Dec 22 | r03 | Korona KielceKorona Kielce | 4 - 0 | Gornik LecznaGornik Leczna |
| 03 Dec 22 | r03 | PEC ZwollePEC Zwolle | 0 - 1 | KV OostendeKV Oostende |
| 03 Dec 22 | r03 | Dundee UnitedDundee United | 0 - 2 | SwanseaSwansea |
| 03 Dec 22 | r03 | Crystal PalaceCrystal Palac | 0 - 0 | Botafogo RJBotafogo RJ |
| 03 Dec 22 | r03 | Almere City FCAlmere City F | 1 - 1 | FC TwenteFC Twente |
| 03 Dec 22 | r03 | FC UtrechtFC Utrecht | - | RFC SeraingRFC Seraing |
| 03 Dec 22 | r03 | LamiaLamia | 0 - 0 | LevadeiakosLevadeiakos |
| 03 Dec 22 | r03 | FC Lausanne-SportFC Lausanne-S | 0 - 1 | FC BaselFC Basel |
| 03 Dec 22 | r03 | Sturm GrazSturm Graz | 1 - 0 | AlmeriaAlmeria |
| 03 Dec 22 | r03 | OFIOFI | 1 - 1 | AnderlechtAnderlecht |
| 04 Dec 22 | r03 | HeartsHearts | - | AlmeriaAlmeria |
| 04 Dec 22 | r03 | BrøndbyBrøndby | 0 - 4 | TenerifeTenerife |
| 04 Dec 22 | r03 | KortrijkKortrijk | 1 - 0 | ExcelsiorExcelsior |
| 04 Dec 22 | r03 | ADO Den HaagADO Den Haag | 0 - 3 | SpartaSparta |
| 04 Dec 22 | r03 | SC CambuurSC Cambuur | 1 - 1 | SC Heracles AlmeloSC Heracles A |
| 04 Dec 22 | r03 | NAC BredaNAC Breda | 0 - 2 | MechelenMechelen |
| 04 Dec 22 | r03 | OlympiakosOlympiakos | 3 - 3 | StandardStandard |
| 04 Dec 22 | r03 | Pafos FCPafos FC | 2 - 2 | PanathinaikosPanathinaikos |
| 04 Dec 22 | r03 | ArisAris | 2 - 2 | Maccabi HaifaMaccabi Haifa |
| 05 Dec 22 | r03 | Legia WarsawLegia Warsaw | 3 - 1 | Tychy 71Tychy 71 |
| 05 Dec 22 | r03 | LivingstonLivingston | 4 - 1 | FK MetalurgsFK Metalurgs |
| 05 Dec 22 | r03 | Sturm GrazSturm Graz | 1 - 2 | EmpoliEmpoli |
| 06 Dec 22 | r03 | GenkGenk | 3 - 1 | SC HeerenveenSC Heerenveen |
| 06 Dec 22 | r03 | Ath BilbaoAth Bilbao | 2 - 0 | ValladolidValladolid |
| 06 Dec 22 | r03 | AtromitosAtromitos | 3 - 2 | Nottingham ForestNottingham Fo |
| 06 Dec 22 | r03 | SV Josko RiedSV Josko Ried | 6 - 1 | First ViennaFirst Vienna |
| 06 Dec 22 | r03 | Cambridge UnitedCambridge Uni | 2 - 4 | West HamWest Ham |
| 07 Dec 22 | r03 | HerthaHertha | 1 - 0 | BraunschweigBraunschweig |
| 07 Dec 22 | r03 | Zurich IIZurich II | - | SchaffhausenSchaffhausen |
| 07 Dec 22 | r03 | BochumBochum | 1 - 3 | PEC ZwollePEC Zwolle |
| 07 Dec 22 | r03 | GrasshoppersGrasshoppers | 0 - 0 | LucerneLucerne |
| 07 Dec 22 | r03 | Sturm GrazSturm Graz | - | NiceNice |
| 07 Dec 22 | r03 | Nea Salamis FamagustaNea Salamis F | 0 - 1 | PanathinaikosPanathinaikos |
| 07 Dec 22 | r03 | FiorentinaFiorentina | 9 - 0 | Always ReadyAlways Ready |
| 07 Dec 22 | r03 | Celta VigoCelta Vigo | 1 - 1 | BoavistaBoavista |
| 07 Dec 22 | r03 | Blau-Weiß LohneBlau-Weiß Loh | 0 - 2 | OsnabrueckOsnabrueck |
| 07 Dec 22 | r03 | SevillaSevilla | 1 - 1 | MonacoMonaco |
| 08 Dec 22 | r03 | CremoneseCremonese | 6 - 0 | SalsomaggioreSalsomaggiore |
| 08 Dec 22 | r03 | GironaGirona | 1 - 0 | StandardStandard |
| 08 Dec 22 | r03 | HibernianHibernian | 1 - 0 | Raith RvsRaith Rvs |
| 08 Dec 22 | r03 | Tatran PresovTatran Presov | 2 - 3 | Dukla Banská BystricaDukla Banská |
| 08 Dec 22 | r03 | Aston VillaAston Villa | 2 - 2 | BrightonBrighton |
| 08 Dec 22 | r03 | FK MetalurgsFK Metalurgs | - | Fortuna SittardFortuna Sitta |
| 08 Dec 22 | r03 | Fortuna SittardFortuna Sitta | 0 - 3 | LivingstonLivingston |
| 08 Dec 22 | r03 | LamiaLamia | 1 - 3 | NFC VolosNFC Volos |
| 08 Dec 22 | r03 | Stade de ReimsStade de Reim | 3 - 0 | SochauxSochaux |
| 08 Dec 22 | r03 | StandardStandard | 1 - 4 | NiceNice |
| 08 Dec 22 | r03 | Al HilalAl Hilal | 0 - 5 | NewcastleNewcastle |
| 08 Dec 22 | r03 | GetafeGetafe | 0 - 1 | CD GuadalajaraCD Guadalajar |
| 08 Dec 22 | r03 | HibernianHibernian | - | Edinburgh CityEdinburgh Cit |
| 08 Dec 22 | r03 | ElcheElche | 1 - 2 | LeedsLeeds |
| 09 Dec 22 | r03 | MetzMetz | 1 - 5 | AuxerreAuxerre |
| 09 Dec 22 | r03 | Tychy 71Tychy 71 | 1 - 5 | Ruch ChorzowRuch Chorzow |
| 09 Dec 22 | r03 | KarvinaKarvina | 1 - 1 | MSK ZilinaMSK Zilina |
| 09 Dec 22 | r03 | PaderbornPaderborn | 1 - 0 | HannoverHannover |
| 09 Dec 22 | r03 | FC GroningenFC Groningen | 1 - 1 | SC CambuurSC Cambuur |
| 09 Dec 22 | r03 | Viktoria KölnViktoria Köln | 1 - 1 | KarlsruheKarlsruhe |
| 09 Dec 22 | r03 | WolvesWolves | 1 - 1 | EmpoliEmpoli |
| 09 Dec 22 | r03 | ZurichZurich | 2 - 1 | DornbirnDornbirn |
| 09 Dec 22 | r03 | FreiburgFreiburg | 2 - 2 | LucerneLucerne |
| 09 Dec 22 | r03 | FC EmmenFC Emmen | - | SV MeppenSV Meppen |
| 09 Dec 22 | r03 | ValenciaValencia | 4 - 2 | Clermont FootClermont Foot |
| 09 Dec 22 | r03 | BolognaBologna | 9 - 0 | SV KapfenbergSV Kapfenberg |
| 09 Dec 22 | r03 | St. GilloiseSt. Gilloise | 0 - 0 | AngersAngers |
| 09 Dec 22 | r03 | Sturm Graz IISturm Graz II | - | Lask Juniors LinzLask Juniors |
| 09 Dec 22 | r03 | StrasbourgStrasbourg | - | VitesseVitesse |
| 09 Dec 22 | r03 | Rapid ViennaRapid Vienna | 2 - 2 | Schalke 04Schalke 04 |
| 09 Dec 22 | r03 | AtalantaAtalanta | 2 - 2 | Ein FrankfurtEin Frankfurt |
| 10 Dec 22 | r03 | RennesRennes | 4 - 3 | CelticCeltic |
| 10 Dec 22 | r03 | SociedadSociedad | 1 - 1 | VallecanoVallecano |
| 10 Dec 22 | r03 | LuganoLugano | 1 - 0 | MonzaMonza |
| 10 Dec 22 | r03 | LeicesterLeicester | 0 - 0 | TroyesTroyes |
| 10 Dec 22 | r03 | LensLens | 2 - 1 | MontpellierMontpellier |
| 10 Dec 22 | r03 | Widzew LodzWidzew Lodz | 0 - 0 | Rukh LvivRukh Lviv |
| 10 Dec 22 | r03 | NiceNice | 0 - 0 | GironaGirona |
| 10 Dec 22 | r03 | ValladolidValladolid | 0 - 2 | LilleLille |
| 10 Dec 22 | r03 | JastrzębieJastrzębie | 3 - 1 | Skra CzęstochowaSkra Częstoch |
| 10 Dec 22 | r03 | GKS KatowiceGKS Katowice | 0 - 1 | Korona KielceKorona Kielce |
| 10 Dec 22 | r03 | Gornik ZabrzeGornik Zabrze | 3 - 1 | Miedz LegnicaMiedz Legnica |
| 10 Dec 22 | r03 | PSV EindhovenPSV Eindhoven | 4 - 2 | Rakow CzestochowaRakow Czestoc |
| 10 Dec 22 | r03 | Arka GdyniaArka Gdynia | 2 - 2 | Chojniczanka ChojniceChojniczanka |
| 10 Dec 22 | r03 | Korona KielceKorona Kielce | 0 - 1 | GKS KatowiceGKS Katowice |
| 10 Dec 22 | r03 | OsasunaOsasuna | 1 - 1 | LorientLorient |
| 10 Dec 22 | r03 | WolfsburgWolfsburg | 1 - 1 | FC NordsjællandFC Nordsjælla |
| 10 Dec 22 | r03 | Club BruggeClub Brugge | 0 - 2 | ExcelsiorExcelsior |
| 10 Dec 22 | r03 | PaderbornPaderborn | 1 - 2 | OsnabrueckOsnabrueck |
| 10 Dec 22 | r03 | BochumBochum | 1 - 2 | KarlsruheKarlsruhe |
| 10 Dec 22 | r03 | BordeauxBordeaux | 2 - 1 | BrentfordBrentford |
| 10 Dec 22 | r03 | AugsburgAugsburg | 3 - 0 | GrasshoppersGrasshoppers |
| 10 Dec 22 | r03 | FC WilFC Wil | 0 - 3 | Freiburg IIFreiburg II |
| 10 Dec 22 | r03 | SKN St. PoltenSKN St. Polte | 0 - 1 | LASKLASK |
| 10 Dec 22 | r03 | LeverkusenLeverkusen | 3 - 0 | RangersRangers |
| 10 Dec 22 | r03 | Dundee UnitedDundee United | - | AyrAyr |
| 10 Dec 22 | r03 | BocholtBocholt | 2 - 3 | OldenburgOldenburg |
| 10 Dec 22 | r03 | FC BaselFC Basel | - | Waldhof MannheimWaldhof Mannh |
| 10 Dec 22 | r03 | UdineseUdinese | 1 - 3 | West HamWest Ham |
| 10 Dec 22 | r03 | QuevillyQuevilly | 1 - 1 | LavalLaval |
| 10 Dec 22 | r03 | EspanolEspanol | 0 - 1 | TorinoTorino |
| 10 Dec 22 | r03 | FC TwenteFC Twente | 2 - 1 | SpartaSparta |
| 10 Dec 22 | r03 | OlympiakosOlympiakos | 1 - 0 | Nottingham ForestNottingham Fo |
| 11 Dec 22 | r03 | SampdoriaSampdoria | 5 - 1 | TS GalaxyTS Galaxy |
| 11 Dec 22 | r03 | NapoliNapoli | 3 - 1 | Crystal PalaceCrystal Palac |
| 11 Dec 22 | r03 | MarseilleMarseille | 2 - 3 | SassuoloSassuolo |
| 11 Dec 22 | r03 | BenficaBenfica | 0 - 1 | SevillaSevilla |
| 11 Dec 22 | r03 | Ath BilbaoAth Bilbao | 2 - 0 | CD GuadalajaraCD Guadalajar |
| 13 Dec 22 | r03 | OsasunaOsasuna | 3 - 0 | BrestBrest |
| 13 Dec 22 | r03 | BraunschweigBraunschweig | - | SC VerlSC Verl |
| 13 Dec 22 | r03 | BrentfordBrentford | 1 - 3 | Celta VigoCelta Vigo |
| 13 Dec 22 | r03 | GuingampGuingamp | 2 - 1 | Le HavreLe Havre |
| 13 Dec 22 | r03 | ValladolidValladolid | 0 - 0 | Clermont FootClermont Foot |
| 13 Dec 22 | r03 | GenkGenk | 1 - 0 | MetzMetz |
| 13 Dec 22 | r03 | St.TruidenSt.Truiden | 3 - 0 | RKC WaalwijkRKC Waalwijk |
| 14 Dec 22 | r03 | GironaGirona | 1 - 1 | OsasunaOsasuna |
| 14 Dec 22 | r03 | CadizCadiz | 3 - 4 | WolvesWolves |
| 14 Dec 22 | r03 | JastrzębieJastrzębie | - | Piast GliwicePiast Gliwice |
| 14 Dec 22 | r03 | EspanolEspanol | 1 - 1 | MechelenMechelen |
| 14 Dec 22 | r03 | AnderlechtAnderlecht | 1 - 1 | Rakow CzestochowaRakow Czestoc |
| 14 Dec 22 | r03 | HoffenheimHoffenheim | 4 - 3 | ElversbergElversberg |
| 14 Dec 22 | r03 | GentGent | 4 - 1 | SC HeerenveenSC Heerenveen |
| 14 Dec 22 | r03 | StandardStandard | 0 - 1 | ValenciennesValenciennes |
| 14 Dec 22 | r03 | OFIOFI | 7 - 0 | IonikosIonikos |
| 14 Dec 22 | r03 | CremoneseCremonese | 7 - 0 | Desenzano CalvinaDesenzano Cal |
| 14 Dec 22 | r03 | AjaccioAjaccio | 1 - 0 | St EtienneSt Etienne |
| 14 Dec 22 | r03 | ServetteServette | 0 - 3 | SpeziaSpezia |
| 14 Dec 22 | r03 | AngersAngers | 0 - 1 | NiortNiort |
| 14 Dec 22 | r03 | Union BerlinUnion Berlin | 2 - 0 | Hansa RostockHansa Rostock |
| 14 Dec 22 | r03 | BastiaBastia | 1 - 2 | FiorentinaFiorentina |
| 14 Dec 22 | r03 | MallorcaMallorca | 1 - 2 | BolognaBologna |
| 15 Dec 22 | r03 | Miedz LegnicaMiedz Legnica | 2 - 0 | JablonecJablonec |
| 15 Dec 22 | r03 | Dynamo DresdenDynamo Dresde | 2 - 1 | TS GalaxyTS Galaxy |
| 15 Dec 22 | r03 | SV MeppenSV Meppen | 1 - 0 | Werder BremenWerder Bremen |
| 15 Dec 22 | r03 | Werder BremenWerder Bremen | 1 - 0 | SV MeppenSV Meppen |
| 15 Dec 22 | r03 | IngolstadtIngolstadt | 1 - 3 | SPVGG Greuther FürthSPVGG Greuthe |
| 15 Dec 22 | r03 | VitesseVitesse | - | ExcelsiorExcelsior |
| 15 Dec 22 | r03 | SevillaSevilla | 7 - 0 | FC VolendamFC Volendam |
| 15 Dec 22 | r03 | BurgosBurgos | 0 - 3 | Ath BilbaoAth Bilbao |
| 15 Dec 22 | r03 | Aston VillaAston Villa | 0 - 1 | VillarrealVillarreal |
| 16 Dec 22 | r03 | SC CambuurSC Cambuur | 0 - 2 | LilleLille |
| 16 Dec 22 | r03 | Legia WarsawLegia Warsaw | 2 - 1 | Ruch ChorzowRuch Chorzow |
| 16 Dec 22 | r03 | Widzew LodzWidzew Lodz | 2 - 0 | Chojniczanka ChojniceChojniczanka |
| 16 Dec 22 | r03 | KaiserslauternKaiserslauter | 2 - 0 | Wehen WiesbadenWehen Wiesbad |
| 16 Dec 22 | r03 | Kickers OffenbachKickers Offen | - | AueAue |
| 16 Dec 22 | r03 | Sparta PragueSparta Prague | 3 - 1 | MSK ZilinaMSK Zilina |
| 16 Dec 22 | r03 | Munich 1860Munich 1860 | 1 - 0 | NurnbergNurnberg |
| 16 Dec 22 | r03 | Stade de ReimsStade de Reim | 3 - 0 | CharleroiCharleroi |
| 16 Dec 22 | r03 | NantesNantes | 1 - 1 | LavalLaval |
| 16 Dec 22 | r03 | MontpellierMontpellier | 5 - 0 | Rodez AFRodez AF |
| 16 Dec 22 | r03 | StuttgartStuttgart | 0 - 3 | LucerneLucerne |
| 16 Dec 22 | r03 | GuingampGuingamp | 1 - 0 | LorientLorient |
| 16 Dec 22 | r03 | EmpoliEmpoli | 0 - 1 | MonacoMonaco |
| 16 Dec 22 | r03 | AlmeriaAlmeria | 1 - 1 | TorinoTorino |
| 16 Dec 22 | r03 | Hajduk SplitHajduk Split | 4 - 3 | Schalke 04Schalke 04 |
| 16 Dec 22 | r03 | CaenCaen | - | QuevillyQuevilly |
| 16 Dec 22 | r03 | Crystal PalaceCrystal Palac | 2 - 1 | ValladolidValladolid |
| 16 Dec 22 | r03 | ValenciaValencia | 1 - 2 | Nottingham ForestNottingham Fo |
| 16 Dec 22 | r03 | NiceNice | 0 - 3 | AtalantaAtalanta |
| 16 Dec 22 | r03 | LeedsLeeds | 2 - 1 | SociedadSociedad |
| 16 Dec 22 | r03 | AlajuelenseAlajuelense | 2 - 2 | FC TwenteFC Twente |
| 17 Dec 22 | r03 | Fortuna SittardFortuna Sitta | - | Rakow CzestochowaRakow Czestoc |
| 17 Dec 22 | r03 | GKS KatowiceGKS Katowice | 0 - 1 | Skra CzęstochowaSkra Częstoch |
| 17 Dec 22 | r03 | LuganoLugano | 3 - 0 | Freiburg IIFreiburg II |
| 17 Dec 22 | r03 | LeverkusenLeverkusen | 4 - 1 | ZurichZurich |
| 17 Dec 22 | r03 | Rot-Weiss EssenRot-Weiss Ess | 3 - 2 | PaderbornPaderborn |
| 17 Dec 22 | r03 | NewcastleNewcastle | 2 - 1 | VallecanoVallecano |
| 17 Dec 22 | r03 | ServetteServette | 1 - 0 | FC UtrechtFC Utrecht |
| 17 Dec 22 | r03 | LASKLASK | 0 - 0 | SpVgg BayreuthSpVgg Bayreut |
| 17 Dec 22 | r03 | FC HeidenheimFC Heidenheim | 2 - 0 | Waldhof MannheimWaldhof Mannh |
| 17 Dec 22 | r03 | FulhamFulham | 1 - 1 | West HamWest Ham |
| 17 Dec 22 | r03 | BrentfordBrentford | 2 - 2 | WolfsburgWolfsburg |
| 17 Dec 22 | r03 | BolognaBologna | - | HNK GoricaHNK Gorica |
| 17 Dec 22 | r03 | SpeziaSpezia | 1 - 3 | SpartaSparta |
| 17 Dec 22 | r03 | FC EmmenFC Emmen | 3 - 2 | NEC NijmegenNEC Nijmegen |
| 17 Dec 22 | r03 | Union BerlinUnion Berlin | 4 - 1 | St. GallenSt. Gallen |
| 17 Dec 22 | r03 | HoffenheimHoffenheim | 3 - 2 | Munich 1860Munich 1860 |
| 17 Dec 22 | r03 | FiorentinaFiorentina | 1 - 1 | MonacoMonaco |
| 17 Dec 22 | r03 | LensLens | 3 - 0 | Le HavreLe Havre |
| 17 Dec 22 | r03 | Clermont FootClermont Foot | - | DijonDijon |
| 17 Dec 22 | r03 | DuisburgDuisburg | 2 - 3 | OldenburgOldenburg |
| 17 Dec 22 | r03 | LyonLyon | 1 - 1 | SochauxSochaux |
| 17 Dec 22 | r03 | AngersAngers | 2 - 2 | AuxerreAuxerre |
| 17 Dec 22 | r03 | DarmstadtDarmstadt | 2 - 0 | Young BoysYoung Boys |
| 17 Dec 22 | r03 | UdineseUdinese | 0 - 1 | Ath BilbaoAth Bilbao |
| 17 Dec 22 | r03 | NapoliNapoli | 2 - 3 | VillarrealVillarreal |
| 18 Dec 22 | r03 | VeronaVerona | 0 - 0 | NK Istra 1961NK Istra 1961 |
| 20 Dec 22 | r03 | MontpellierMontpellier | - | ToulouseToulouse |
| 20 Dec 22 | r03 | Munich 1860Munich 1860 | - | SpVgg BayreuthSpVgg Bayreut |
| 20 Dec 22 | r03 | Sparta PragueSparta Prague | - | VarnsdorfVarnsdorf |
| 20 Dec 22 | r03 | HoffenheimHoffenheim | 3 - 3 | SPVGG Greuther FürthSPVGG Greuthe |
| 20 Dec 22 | r03 | FC GroningenFC Groningen | 2 - 0 | SpeziaSpezia |
| 20 Dec 22 | r03 | SampdoriaSampdoria | 2 - 2 | Dynamo DresdenDynamo Dresde |
| 20 Dec 22 | r03 | Clermont FootClermont Foot | 0 - 1 | SochauxSochaux |
| 21 Dec 22 | r03 | FC HeidenheimFC Heidenheim | 0 - 1 | IngolstadtIngolstadt |
| 21 Dec 22 | r03 | BochumBochum | 0 - 2 | SC VerlSC Verl |
| 21 Dec 22 | r03 | MagdeburgMagdeburg | 2 - 3 | ZwickauZwickau |
| 21 Dec 22 | r03 | Wehen WiesbadenWehen Wiesbad | 2 - 0 | Waldhof MannheimWaldhof Mannh |
| 21 Dec 22 | r03 | AnnecyAnnecy | 4 - 2 | ServetteServette |
| 21 Dec 22 | r03 | MetzMetz | 2 - 1 | ElversbergElversberg |
| 21 Dec 22 | r03 | Paris FCParis FC | 1 - 0 | TroyesTroyes |
| 21 Dec 22 | r03 | Stade de ReimsStade de Reim | 1 - 2 | LensLens |
| 21 Dec 22 | r03 | StrasbourgStrasbourg | 1 - 1 | KarlsruheKarlsruhe |
| 21 Dec 22 | r03 | RennesRennes | - | AngersAngers |
| 21 Dec 22 | r03 | FiorentinaFiorentina | 6 - 1 | LuganoLugano |
| 21 Dec 22 | r03 | AuxerreAuxerre | 1 - 0 | Hajduk SplitHajduk Split |
| 21 Dec 22 | r03 | LorientLorient | 2 - 1 | NantesNantes |
| 21 Dec 22 | r03 | LeedsLeeds | 2 - 4 | MonacoMonaco |
| 22 Dec 22 | r03 | ValenciaValencia | 1 - 3 | AZ AlkmaarAZ Alkmaar |
| 22 Dec 22 | r03 | SpartaSparta | 1 - 0 | VitesseVitesse |
| 22 Dec 22 | r03 | VeronaVerona | 0 - 1 | BolognaBologna |
| 22 Dec 22 | r03 | SC HeerenveenSC Heerenveen | 1 - 1 | ExcelsiorExcelsior |
| 22 Dec 22 | r03 | DuisburgDuisburg | 1 - 1 | Fortuna SittardFortuna Sitta |
| 22 Dec 22 | r03 | RennesRennes | 3 - 1 | BrestBrest |
| 22 Dec 22 | r03 | LyonLyon | 1 - 2 | MonzaMonza |
| 22 Dec 22 | r03 | OsnabrueckOsnabrueck | 2 - 2 | Schalke 04Schalke 04 |
| 23 Dec 22 | r03 | ThunThun | - | Freiburg IIFreiburg II |
| 23 Dec 22 | r03 | FC UtrechtFC Utrecht | 0 - 3 | FC GroningenFC Groningen |
| 23 Dec 22 | r03 | FC EmmenFC Emmen | 4 - 0 | FC DordrechtFC Dordrecht |
| 23 Dec 22 | r03 | TorinoTorino | 0 - 0 | CremoneseCremonese |
| 23 Dec 22 | r03 | UdineseUdinese | 2 - 0 | LecceLecce |
| 23 Dec 22 | r03 | EmpoliEmpoli | 2 - 1 | SassuoloSassuolo |
| 23 Dec 22 | r03 | BetisBetis | 0 - 3 | AtalantaAtalanta |
| 29 Dec 22 | r03 | CremoneseCremonese | 1 - 3 | UdineseUdinese |
| 29 Dec 22 | r03 | AtalantaAtalanta | 0 - 1 | AZ AlkmaarAZ Alkmaar |
| 30 Dec 22 | r03 | Willem IIWillem II | 3 - 1 | ExcelsiorExcelsior |
| 30 Dec 22 | r03 | ThunThun | 2 - 1 | FC SionFC Sion |
| 30 Dec 22 | r03 | WesterloWesterlo | - | SpartaSparta |
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