| 18 Aug 20 | r05        | Vendée Fontenay FootVendée Fonten | 0 - 1 | Stade Poitevin FCStade Poitevi |
| 18 Aug 20 | r05        | BVV BarendrechtBVV Barendrec | - | VV DongenVV Dongen |
| 22 Aug 20 | r05        | VV KatwijkVV Katwijk | 0 - 0 | FC EindhovenFC Eindhoven |
| 22 Aug 20 | r05        | Rijnsburgse BoysRijnsburgse B | 3 - 0 | USV HerculesUSV Hercules |
| 22 Aug 20 | r05        | Amsterdamsche FCAmsterdamsche | 1 - 0 | IJsselmeervogelsIJsselmeervog |
| 22 Aug 20 | r05        | IJsselmeervogelsIJsselmeervog | - | SC TelstarSC Telstar |
| 22 Aug 20 | r05        | Sparta NijkerkSparta Nijker | 2 - 2 | GVVVGVVV |
| 22 Aug 20 | r05        | Jong AZJong AZ | - | Amsterdamsche FCAmsterdamsche |
| 28 Aug 20 | r05        | BangorBangor | 1 - 2 | ArdsArds |
| 29 Aug 20 | r05        | Rijnsburgse BoysRijnsburgse B | 3 - 0 | Jong VolendamJong Volendam |
| 29 Aug 20 | r05        | Central Sport ClubCentral Sport | 2 - 0 | CampinenseCampinense |
| 01 Sep 20 | r05        | SC TelstarSC Telstar | - | Rijnsburgse BoysRijnsburgse B |
| 10 Jul 21 | r05        | Osijek IIOsijek II | 1 - 0 | BSK Bijelo BrdoBSK Bijelo Br |
| 10 Jul 21 | r05        | Szombathelyi HaladásSzombathelyi | 1 - 1 | AjkaAjka |
| 10 Jul 21 | r05        | Mezőkövesdi SEMezőkövesdi S | 4 - 0 | TiszakécskeTiszakécske |
| 10 Jul 21 | r05        | Pirin BlagoevgradPirin Blagoev | 6 - 1 | Neftochimic BurgasNeftochimic B |
| 10 Jul 21 | r05        | Slavia MozyrSlavia Mozyr | 1 - 2 | GomelGomel |
| 10 Jul 21 | r05        | Universitatea ClujUniversitatea | 0 - 2 | Unirea DejUnirea Dej |
| 10 Jul 21 | r05        | Unirea SloboziaUnirea Sloboz | 0 - 1 | MetaloglobusMetaloglobus |
| 10 Jul 21 | r05        | Mlada BoleslavMlada Bolesla | 1 - 3 | ChrudimChrudim |
| 10 Jul 21 | r05        | Santa ClaraSanta Clara | 1 - 2 | Gil VicenteGil Vicente |
| 10 Jul 21 | r05        | Fortuna SittardFortuna Sitta | - | MVV MaastrichtMVV Maastrich |
| 10 Jul 21 | r05        | FC UtrechtFC Utrecht | 1 - 1 | AnderlechtAnderlecht |
| 10 Jul 21 | r05        | Quick BoysQuick Boys | 2 - 5 | Willem IIWillem II |
| 10 Jul 21 | r05        | AntwerpAntwerp | 1 - 1 | FC NordsjællandFC Nordsjælla |
| 10 Jul 21 | r05        | FK PirmasensFK Pirmasens | 2 - 2 | Viktoria AschaffenburgViktoria Asch |
| 10 Jul 21 | r05        | Aberystwyth TownAberystwyth T | 0 - 2 | Cardiff Metropolitan UnivCardiff Metro |
| 10 Jul 21 | r05        | SV BabelsbergSV Babelsberg | 1 - 3 | HerthaHertha |
| 10 Jul 21 | r05        | Nyva TernopilNyva Ternopil | 1 - 0 | Rukh LvivRukh Lviv |
| 10 Jul 21 | r05        | Dorking WanderersDorking Wande | 2 - 1 | HorshamHorsham |
| 10 Jul 21 | r05        | USL DunkerqueUSL Dunkerque | 3 - 0 | Mouscron-PeruwelzMouscron-Peru |
| 10 Jul 21 | r05        | FC Rodina MoscowFC Rodina Mos | 2 - 0 | FC RyazanFC Ryazan |
| 10 Jul 21 | r05        | BeroeBeroe | 2 - 0 | Septemvri SofiaSeptemvri Sof |
| 10 Jul 21 | r05        | Marek DupnitsaMarek Dupnits | 2 - 1 | Sportist SvogeSportist Svog |
| 10 Jul 21 | r05        | FC RouenFC Rouen | 1 - 1 | BoulogneBoulogne |
| 10 Jul 21 | r05        | Radnički Sremska MitrovicRadnički Srem | 2 - 1 | InđijaInđija |
| 10 Jul 21 | r05        | Zvijezda 09Zvijezda 09 | 0 - 0 | LoznicaLoznica |
| 10 Jul 21 | r05        | SkopjeSkopje | 0 - 1 | Napredak KruševacNapredak Kruš |
| 10 Jul 21 | r05        | FC ChamblyFC Chambly | 1 - 0 | FC Versailles 78FC Versailles |
| 10 Jul 21 | r05        | Hrvatski DragovoljacHrvatski Drag | 4 - 0 | KustošijaKustošija |
| 10 Jul 21 | r05        | IMT Novi BeogradIMT Novi Beog | 0 - 3 | Buducnost DobanovciBuducnost Dob |
| 10 Jul 21 | r05        | Le HavreLe Havre | 2 - 2 | RennesRennes |
| 10 Jul 21 | r05        | NK LokomotivaNK Lokomotiva | 2 - 1 | Tuzla CityTuzla City |
| 10 Jul 21 | r05        | Paris FCParis FC | 3 - 0 | QuevillyQuevilly |
| 10 Jul 21 | r05        | RabotnichkiRabotnichki | 0 - 2 | Akademija PandevAkademija Pan |
| 10 Jul 21 | r05        | CSKA SofiaCSKA Sofia | 4 - 0 | Botev VratsaBotev Vratsa |
| 10 Jul 21 | r05        | OFK PetrovacOFK Petrovac | 1 - 1 | Iskra DanilovgradIskra Danilov |
| 10 Jul 21 | r05        | VoždovacVoždovac | 1 - 1 | KolubaraKolubara |
| 10 Jul 21 | r05        | Radnik BijeljinaRadnik Bijelj | 1 - 1 | Mačva ŠabacMačva Šabac |
| 10 Jul 21 | r05        | CF AmericaCF America | 1 - 0 | TigresTigres |
| 11 Jul 21 | r05        | Rukh LvivRukh Lviv | 1 - 0 | Veres RivneVeres Rivne |
| 11 Jul 21 | r05        | Zenit St PetersburgZenit St Pete | 3 - 1 | KarlsruheKarlsruhe |
| 11 Jul 21 | r05        | OrleansOrleans | 1 - 2 | ChateaurouxChateauroux |
| 11 Jul 21 | r05        | Universitatea CraiovaUniversitatea | 7 - 0 | PanduriiPandurii |
| 11 Jul 21 | r05        | AlajuelenseAlajuelense | 0 - 1 | DC UnitedDC United |
| 11 Jul 21 | r05        | DC UnitedDC United | - | AlianzaAlianza |
| 12 Jul 21 | r05        | Bohemians 1905Bohemians 190 | - | Apollon LimassolApollon Limas |
| 12 Jul 21 | r05        | Hapoel Tel-AvivHapoel Tel-Av | 2 - 0 | Sektzia Nes TzionaSektzia Nes T |
| 12 Jul 21 | r05        | SlovackoSlovacko | 1 - 0 | NyíregyházaNyíregyháza |
| 12 Jul 21 | r05        | MaritimoMaritimo | 3 - 0 | Braga BBraga B |
| 12 Jul 21 | r05        | Cambrian & Clydach ValeCambrian & Cl | 3 - 5 | Pen-y-BontPen-y-Bont |
| 13 Jul 21 | r05        | DijonDijon | 0 - 3 | Bourg-PeronnasBourg-Peronna |
| 13 Jul 21 | r05        | MornarMornar | 0 - 0 | Iskra DanilovgradIskra Danilov |
| 13 Jul 21 | r05        | ZoryaZorya | 2 - 1 | AlanyasporAlanyaspor |
| 13 Jul 21 | r05        | PrykarpattiaPrykarpattia | 0 - 1 | KarpatyKarpaty |
| 13 Jul 21 | r05        | Rudar PljevljaRudar Pljevlj | 5 - 1 | TiszakécskeTiszakécske |
| 13 Jul 21 | r05        | Rumilly-VallièresRumilly-Valli | - | DijonDijon |
| 13 Jul 21 | r05        | Nyva TernopilNyva Ternopil | 1 - 2 | AhrobiznesAhrobiznes |
| 13 Jul 21 | r05        | ViOn Zlaté MoravceViOn Zlaté Mo | 0 - 2 | CSKA MoscowCSKA Moscow |
| 13 Jul 21 | r05        | Cartagena FCCartagena FC | 0 - 0 | Al-WehdaAl-Wehda |
| 13 Jul 21 | r05        | ToulouseToulouse | 1 - 2 | Real Sociedad BReal Sociedad |
| 13 Jul 21 | r05        | Kings Lynn TownKings Lynn To | 1 - 3 | Milton Keynes DonsMilton Keynes |
| 13 Jul 21 | r05        | Ammanford AFCAmmanford AFC | 1 - 2 | Haverfordwest CountyHaverfordwest |
| 13 Jul 21 | r05        | BillericayBillericay | 0 - 3 | ColchesterColchester |
| 13 Jul 21 | r05        | Tonbridge AngelsTonbridge Ang | 1 - 0 | LewesLewes |
| 14 Jul 21 | r05        | AlianzaAlianza | - | AlajuelenseAlajuelense |
| 14 Jul 21 | r05        | Austin FCAustin FC | 1 - 3 | TigresTigres |
| 14 Jul 21 | r05        | GyirmótGyirmót | 5 - 0 | Inter BratislavaInter Bratisl |
| 14 Jul 21 | r05        | ChavesChaves | - | Gil VicenteGil Vicente |
| 14 Jul 21 | r05        | SevanSevan | 1 - 0 | NoravankNoravank |
| 14 Jul 21 | r05        | PaderbornPaderborn | 2 - 1 | BraunschweigBraunschweig |
| 14 Jul 21 | r05        | LilleLille | 0 - 1 | GentGent |
| 14 Jul 21 | r05        | Makedonija GjPMakedonija Gj | 1 - 1 | InhuletsInhulets |
| 14 Jul 21 | r05        | CSA Steaua BucureştiCSA Steaua Bu | 3 - 1 | Astra Astra |
| 14 Jul 21 | r05        | Benfica BBenfica B | 3 - 1 | União de LeiriaUnião de Leir |
| 14 Jul 21 | r05        | OrleansOrleans | 1 - 3 | CaenCaen |
| 14 Jul 21 | r05        | NK VaraždinNK Varaždin | 4 - 0 | DubravaDubrava |
| 14 Jul 21 | r05        | Akademija PandevAkademija Pan | 0 - 2 | SkopjeSkopje |
| 14 Jul 21 | r05        | CibaliaCibalia | 0 - 2 | BSK Bijelo BrdoBSK Bijelo Br |
| 14 Jul 21 | r05        | Orijent 1919Orijent 1919 | 1 - 1 | OpatijaOpatija |
| 14 Jul 21 | r05        | QuevillyQuevilly | 0 - 1 | Red StarRed Star |
| 14 Jul 21 | r05        | Uta AradUta Arad | 3 - 2 | Ripensia TimisoaraRipensia Timi |
| 14 Jul 21 | r05        | Eintracht TrierEintracht Tri | - | Rot-Weiß KoblenzRot-Weiß Kobl |
| 14 Jul 21 | r05        | TamworthTamworth | 3 - 1 | West BromWest Brom |
| 14 Jul 21 | r05        | Sporting CPSporting CP | 2 - 2 | PortimonensePortimonense |
| 15 Jul 21 | r05        | DC UnitedDC United | 1 - 0 | AlianzaAlianza |
| 15 Jul 21 | r05        | Zlatibor ČajetinaZlatibor Čaje | 0 - 1 | Iskra DanilovgradIskra Danilov |
| 15 Jul 21 | r05        | Santa ClaraSanta Clara | - | F.C. Paços de FerreiraF.C. Paços de |
| 15 Jul 21 | r05        | Zaglebie LubinZaglebie Lubi | 0 - 1 | Warta PoznańWarta Poznań |
| 15 Jul 21 | r05        | Dynamo KievDynamo Kiev | 3 - 0 | Thonon Évian F.C.Thonon Évian |
| 15 Jul 21 | r05        | Hapoel Nof HaGalilHapoel Nof Ha | 0 - 2 | Hapoel Tel-AvivHapoel Tel-Av |
| 15 Jul 21 | r05        | Paksi FCPaksi FC | 1 - 2 | SlovackoSlovacko |
| 15 Jul 21 | r05        | Atlético PetróleosAtlético Petr | 2 - 0 | InterclubeInterclube |
| 15 Jul 21 | r05        | Arda KardzhaliArda Kardzhal | 2 - 0 | BeroeBeroe |
| 15 Jul 21 | r05        | Sporting CPSporting CP | 2 - 1 | BelenensesBelenenses |
| 16 Jul 21 | r05        | FC VolendamFC Volendam | 2 - 1 | SC Heracles AlmeloSC Heracles A |
| 16 Jul 21 | r05        | Lechia GdańskLechia Gdańsk | 3 - 2 | FK PanevėžysFK Panevėžys |
| 16 Jul 21 | r05        | Ħamrun SpartansĦamrun Sparta | 0 - 0 | Santa Lucia FCSanta Lucia F |
| 16 Jul 21 | r05        | ColneColne | 1 - 0 | Hyde UnitedHyde United |
| 16 Jul 21 | r05        | Bishops StortfordBishops Stort | 2 - 2 | Maldon & TiptreeMaldon & Tipt |
| 16 Jul 21 | r05        | Sektzia Nes TzionaSektzia Nes T | 3 - 1 | Hapoel Ramat HaSharonHapoel Ramat |
| 16 Jul 21 | r05        | Maccabi Netanya Maccabi Netan | 0 - 2 | Kafr QasimKafr Qasim |
| 16 Jul 21 | r05        | Cracovia KrakowCracovia Krak | 0 - 4 | NiecieczaNieciecza |
| 16 Jul 21 | r05        | FK Senica FK Senica | 0 - 5 | Bohemians 1905Bohemians 190 |
| 16 Jul 21 | r05        | VaduzVaduz | 1 - 1 | FreiburgFreiburg |
| 16 Jul 21 | r05        | Podillya KhmelnytskyiPodillya Khme | 3 - 2 | FC Kolos KovalivkaFC Kolos Kova |
| 16 Jul 21 | r05        | NimesNimes | - | Sète 34Sète 34 |
| 16 Jul 21 | r05        | Stade BriochinStade Briochi | 1 - 1 | FC Versailles 78FC Versailles |
| 16 Jul 21 | r05        | US AvranchesUS Avranches | 2 - 5 | ConcarneauConcarneau |
| 16 Jul 21 | r05        | FC GroningenFC Groningen | 2 - 3 | SC VerlSC Verl |
| 16 Jul 21 | r05        | LavalLaval | 1 - 2 | SO CholetSO Cholet |
| 16 Jul 21 | r05        | FC VillefrancheFC Villefranc | 1 - 0 | Le Puy Foot 43Le Puy Foot 4 |
| 16 Jul 21 | r05        | KrkaKrka | 0 - 2 | Budafoki MTEBudafoki MTE |
| 16 Jul 21 | r05        | NiceNice | 0 - 1 | BastiaBastia |
| 16 Jul 21 | r05        | Bath CityBath City | 3 - 4 | ExeterExeter |
| 17 Jul 21 | r05        | MafraMafra | 2 - 0 | VilafranquenseVilafranquens |
| 17 Jul 21 | r05        | PécsPécs | 1 - 0 | SiófokSiófok |
| 17 Jul 21 | r05        | KV OostendeKV Oostende | 0 - 0 | Mouscron-PeruwelzMouscron-Peru |
| 17 Jul 21 | r05        | Næstved BKNæstved BK | 2 - 3 | HillerødHillerød |
| 17 Jul 21 | r05        | IngolstadtIngolstadt | 1 - 1 | SPVGG Greuther FürthSPVGG Greuthe |
| 17 Jul 21 | r05        | HamburgHamburg | 1 - 0 | FC BaselFC Basel |
| 17 Jul 21 | r05        | Dorking WanderersDorking Wande | 4 - 0 | LeatherheadLeatherhead |
| 17 Jul 21 | r05        | Haringey BoroughHaringey Boro | 0 - 0 | BillericayBillericay |
| 17 Jul 21 | r05        | Hednesford TownHednesford To | 1 - 0 | Stafford RangersStafford Rang |
| 17 Jul 21 | r05        | Swindon SupermarineSwindon Super | 0 - 2 | Gloucester CityGloucester Ci |
| 17 Jul 21 | r05        | SzolnokSzolnok | 1 - 1 | KosiceKosice |
| 17 Jul 21 | r05        | BurgosBurgos | 0 - 0 | LugoLugo |
| 17 Jul 21 | r05        | CalahorraCalahorra | 2 - 1 | EibarEibar |
| 17 Jul 21 | r05        | Litex LovechLitex Lovech | 0 - 1 | Minyor PernikMinyor Pernik |
| 17 Jul 21 | r05        | Hessen KasselHessen Kassel | 4 - 0 | Wuppertaler SVWuppertaler S |
| 17 Jul 21 | r05        | TSV Steinbach HaigerTSV Steinbach | 1 - 1 | Schalke 04 IISchalke 04 II |
| 17 Jul 21 | r05        | DergviewDergview | 0 - 1 | Ballinamallard UnitedBallinamallar |
| 17 Jul 21 | r05        | Iskra DanilovgradIskra Danilov | 1 - 2 | Bregalnica ŠtipBregalnica Št |
| 17 Jul 21 | r05        | Kings LangleyKings Langley | 1 - 2 | St Albans CitySt Albans Cit |
| 17 Jul 21 | r05        | AlcorconAlcorcon | 1 - 2 | FuenlabradaFuenlabrada |
| 17 Jul 21 | r05        | ChelseaChelsea | 6 - 1 | PeterboroPeterboro |
| 17 Jul 21 | r05        | Mezőkövesdi SEMezőkövesdi S | - | DiosgyorDiosgyor |
| 17 Jul 21 | r05        | Kispest HonvedKispest Honve | 1 - 0 | FK RostovFK Rostov |
| 17 Jul 21 | r05        | VasasVasas | 3 - 2 | KazincbarcikaKazincbarcika |
| 17 Jul 21 | r05        | CovilhaCovilha | 1 - 1 | PortimonensePortimonense |
| 17 Jul 21 | r05        | Sandecja Nowy SaczSandecja Nowy | 4 - 2 | Puszcza NiepołomicePuszcza Niepo |
| 17 Jul 21 | r05        | BełchatówBełchatów | 1 - 1 | Polonia WarsawPolonia Warsa |
| 17 Jul 21 | r05        | AC HorsensAC Horsens | 2 - 0 | FredericiaFredericia |
| 17 Jul 21 | r05        | São João de VerSão João de V | - | União de LeiriaUnião de Leir |
| 17 Jul 21 | r05        | Korona KielceKorona Kielce | 2 - 2 | LKS LodzLKS Lodz |
| 17 Jul 21 | r05        | CharleroiCharleroi | 0 - 2 | PAOKPAOK |
| 17 Jul 21 | r05        | Hannoverscher SCHannoverscher | 1 - 2 | St Pauli IISt Pauli II |
| 17 Jul 21 | r05        | Viktoria BerlinViktoria Berl | 1 - 1 | Chemnitzer FCChemnitzer FC |
| 17 Jul 21 | r05        | DortmundDortmund | 1 - 3 | BochumBochum |
| 17 Jul 21 | r05        | DuisburgDuisburg | - | DortmundDortmund |
| 17 Jul 21 | r05        | Ebbsfleet UnitedEbbsfleet Uni | - | GillinghamGillingham |
| 17 Jul 21 | r05        | NantesNantes | 0 - 1 | CaenCaen |
| 17 Jul 21 | r05        | Beerschot VABeerschot VA | 1 - 1 | Fortuna SittardFortuna Sitta |
| 17 Jul 21 | r05        | Havant & WaterloovilleHavant & Wate | 2 - 3 | Bognor Regis TownBognor Regis |
| 17 Jul 21 | r05        | NancyNancy | 2 - 2 | GuingampGuingamp |
| 17 Jul 21 | r05        | FC RouenFC Rouen | 1 - 2 | Olympique Saint-QuentinOlympique Sai |
| 17 Jul 21 | r05        | Buxton F.C.Buxton F.C. | - | Barwell FCBarwell FC |
| 17 Jul 21 | r05        | Paris FCParis FC | 2 - 2 | CreteilCreteil |
| 17 Jul 21 | r05        | AFC SudburyAFC Sudbury | 1 - 2 | Brightlingsea RegentBrightlingsea |
| 17 Jul 21 | r05        | AngersAngers | 3 - 0 | ChateaurouxChateauroux |
| 17 Jul 21 | r05        | AnnecyAnnecy | 2 - 1 | ToulonToulon |
| 17 Jul 21 | r05        | USL DunkerqueUSL Dunkerque | 1 - 0 | BoulogneBoulogne |
| 17 Jul 21 | r05        | GyorGyor | 2 - 2 | Al HazmAl Hazm |
| 17 Jul 21 | r05        | Makedonija GjPMakedonija Gj | 1 - 2 | CSKA 1948CSKA 1948 |
| 17 Jul 21 | r05        | Cartagena FCCartagena FC | 2 - 0 | Al-RaedAl-Raed |
| 17 Jul 21 | r05        | Pau FCPau FC | 0 - 0 | Canet RoussillonCanet Roussil |
| 17 Jul 21 | r05        | QuevillyQuevilly | 0 - 1 | Le MansLe Mans |
| 17 Jul 21 | r05        | SociedadSociedad | 6 - 1 | HuescaHuesca |
| 18 Jul 21 | r05        | Rakow CzestochowaRakow Czestoc | 2 - 0 | Skra CzęstochowaSkra Częstoch |
| 18 Jul 21 | r05        | ErzurumsporErzurumspor | 1 - 2 | AntalyasporAntalyaspor |
| 18 Jul 21 | r05        | BordeauxBordeaux | 2 - 1 | CaenCaen |
| 18 Jul 21 | r05        | RizesporRizespor | 2 - 3 | KocaelisporKocaelispor |
| 18 Jul 21 | r05        | FSV FrankfurtFSV Frankfurt | 3 - 1 | Waldhof MannheimWaldhof Mannh |
| 18 Jul 21 | r05        | Terek GroznyTerek Grozny | 0 - 0 | Szombathelyi HaladásSzombathelyi |
| 18 Jul 21 | r05        | AtalantaAtalanta | 1 - 1 | Maccabi Bnei RainaMaccabi Bnei |
| 18 Jul 21 | r05        | Gaziantep FKGaziantep FK | 1 - 5 | MalatyasporMalatyaspor |
| 18 Jul 21 | r05        | MechelenMechelen | 1 - 3 | WesterloWesterlo |
| 18 Jul 21 | r05        | PortimonensePortimonense | 0 - 0 | SC FarenseSC Farense |
| 18 Jul 21 | r05        | Hampton & RichmondHampton & Ric | - | Carshalton AthleticCarshalton At |
| 18 Jul 21 | r05        | NiortNiort | 1 - 0 | NantesNantes |
| 18 Jul 21 | r05        | FC 03 Differdange FC 03 Differd | 4 - 0 | UT PétangeUT Pétange |
| 18 Jul 21 | r05        | Rudar PljevljaRudar Pljevlj | 1 - 0 | NyíregyházaNyíregyháza |
| 18 Jul 21 | r05        | DesnaDesna | 2 - 0 | Veres RivneVeres Rivne |
| 18 Jul 21 | r05        | TikvešTikveš | 0 - 1 | RenovaRenova |
| 18 Jul 21 | r05        | PoblensePoblense | 0 - 1 | MallorcaMallorca |
| 19 Jul 21 | r05        | CSKA MoscowCSKA Moscow | 2 - 1 | Nizhny NovgorodNizhny Novgor |
| 19 Jul 21 | r05        | AveleyAveley | 5 - 2 | East Thurrock UnitedEast Thurrock |
| 19 Jul 21 | r05        | NyíregyházaNyíregyháza | 2 - 0 | Beitar JerusalemBeitar Jerusa |
| 19 Jul 21 | r05        | BrønshøjBrønshøj | 1 - 0 | Hvidovre IFHvidovre IF |
| 19 Jul 21 | r05        | Terek GroznyTerek Grozny | 2 - 2 | Al Fateh FCAl Fateh FC |
| 19 Jul 21 | r05        | BournemouthBournemouth | 0 - 0 | GranadaGranada |
| 20 Jul 21 | r05        | Ein FrankfurtEin Frankfurt | 6 - 1 | FC GießenFC Gießen |
| 20 Jul 21 | r05        | Chippenham Town FCChippenham To | 1 - 2 | NewportNewport |
| 20 Jul 21 | r05        | Carshalton AthleticCarshalton At | 1 - 3 | DartfordDartford |
| 20 Jul 21 | r05        | TSV Steinbach HaigerTSV Steinbach | 2 - 4 | Wuppertaler SVWuppertaler S |
| 20 Jul 21 | r05        | CalahorraCalahorra | 2 - 0 | ZaragozaZaragoza |
| 20 Jul 21 | r05        | Northwich VictoriaNorthwich Vic | 1 - 5 | Chester CityChester City |
| 20 Jul 21 | r05        | Oxford UtdOxford Utd | 9 - 0 | Hayes & Yeading UnitedHayes & Yeadi |
| 20 Jul 21 | r05        | Kings LangleyKings Langley | 1 - 3 | Slough TownSlough Town |
| 20 Jul 21 | r05        | West BromWest Brom | 2 - 0 | Sheffield WedsSheffield Wed |
| 20 Jul 21 | r05        | Paris FCParis FC | - | CreteilCreteil |
| 20 Jul 21 | r05        | Shakhtar DonetskShakhtar Done | 5 - 0 | Obolon-BrovarObolon-Brovar |
| 20 Jul 21 | r05        | FA 2000FA 2000 | 0 - 0 | VanløseVanløse |
| 20 Jul 21 | r05        | Wacker InnsbruckWacker Innsbr | 1 - 1 | LiverpoolLiverpool |
| 20 Jul 21 | r05        | Le Puy Foot 43Le Puy Foot 4 | 1 - 2 | Bourg-PeronnasBourg-Peronna |
| 20 Jul 21 | r05        | Al AinAl Ain | - | Al-Nasr SalalahAl-Nasr Salal |
| 20 Jul 21 | r05        | StuttgartStuttgart | 1 - 0 | Wacker InnsbruckWacker Innsbr |
| 20 Jul 21 | r05        | Ebbsfleet UnitedEbbsfleet Uni | - | ColchesterColchester |
| 20 Jul 21 | r05        | SwindonSwindon | 3 - 2 | Swindon SupermarineSwindon Super |
| 20 Jul 21 | r05        | Haringey BoroughHaringey Boro | 0 - 4 | Sutton UnitedSutton United |
| 20 Jul 21 | r05        | Bishops StortfordBishops Stort | - | Kings Lynn TownKings Lynn To |
| 20 Jul 21 | r05        | Flint Town UnitedFlint Town Un | 3 - 1 | MarineMarine |
| 21 Jul 21 | r05        | MallorcaMallorca | 1 - 0 | Cartagena FCCartagena FC |
| 21 Jul 21 | r05        | Paris SGParis SG | 2 - 1 | AugsburgAugsburg |
| 21 Jul 21 | r05        | OsasunaOsasuna | 2 - 1 | HuescaHuesca |
| 21 Jul 21 | r05        | Zaglebie LubinZaglebie Lubi | 2 - 2 | Górnik PolkowiceGórnik Polkow |
| 21 Jul 21 | r05        | RegginaReggina | 4 - 1 | A.S.D. Città di Foligno 1A.S.D. Città |
| 21 Jul 21 | r05        | Skra CzęstochowaSkra Częstoch | 0 - 2 | Aris LimassolAris Limassol |
| 21 Jul 21 | r05        | CSA Steaua BucureştiCSA Steaua Bu | 2 - 2 | MetaloglobusMetaloglobus |
| 21 Jul 21 | r05        | SalernitanaSalernitana | 3 - 2 | SambenedetteseSambenedettes |
| 21 Jul 21 | r05        | UD IbizaUD Ibiza | 2 - 0 | Al-RaedAl-Raed |
| 21 Jul 21 | r05        | SantanderSantander | 2 - 1 | SD AmorebietaSD Amorebieta |
| 21 Jul 21 | r05        | CD Nacional de MadeiraCD Nacional d | 1 - 0 | PevidémPevidém |
| 21 Jul 21 | r05        | VilafranquenseVilafranquens | 0 - 1 | TorreenseTorreense |
| 21 Jul 21 | r05        | RomaRoma | - | TriestinaTriestina |
| 21 Jul 21 | r05        | Bačka PalankaBačka Palanka | 1 - 2 | Bregalnica ŠtipBregalnica Št |
| 21 Jul 21 | r05        | FC ChamblyFC Chambly | - | Stade de ReimsStade de Reim |
| 21 Jul 21 | r05        | SiófokSiófok | 0 - 0 | Al HazmAl Hazm |
| 21 Jul 21 | r05        | RenovaRenova | 0 - 1 | RabotnichkiRabotnichki |
| 21 Jul 21 | r05        | InterInter | 4 - 0 | Pro VercelliPro Vercelli |
| 21 Jul 21 | r05        | OFIOFI | - | Fortuna SittardFortuna Sitta |
| 21 Jul 21 | r05        | FC VillefrancheFC Villefranc | - | Jura Sud FootJura Sud Foot |
| 21 Jul 21 | r05        | SolinSolin | 0 - 1 | RNK SplitRNK Split |
| 21 Jul 21 | r05        | DuisburgDuisburg | 0 - 3 | VfB HombergVfB Homberg |
| 21 Jul 21 | r05        | EibarEibar | - | SD LogroñésSD Logroñés |
| 21 Jul 21 | r05        | Voltigeurs de ChâteaubriaVoltigeurs de | 0 - 1 | LavalLaval |
| 21 Jul 21 | r05        | Real OviedoReal Oviedo | - | ExtremaduraExtremadura |
| 21 Jul 21 | r05        | EpinalEpinal | 0 - 2 | MulhouseMulhouse |
| 21 Jul 21 | r05        | Las PalmasLas Palmas | 1 - 0 | EspanolEspanol |
| 21 Jul 21 | r05        | LugoLugo | 1 - 0 | PonferradinaPonferradina |
| 21 Jul 21 | r05        | VallecanoVallecano | 2 - 2 | Al ShababAl Shabab |
| 21 Jul 21 | r05        | Eintracht TrierEintracht Tri | 2 - 1 | Mondorf-les-BainsMondorf-les-B |
| 21 Jul 21 | r05        | TalaveraTalavera | 0 - 2 | AlcorconAlcorcon |
| 21 Jul 21 | r05        | GainsboroughGainsborough | 2 - 1 | LincolnLincoln |
| 22 Jul 21 | r05        | BeneventoBenevento | 2 - 2 | A.S.D. Città di Foligno 1A.S.D. Città |
| 22 Jul 21 | r05        | Beitar JerusalemBeitar Jerusa | 0 - 0 | AEK LarnacaAEK Larnaca |
| 22 Jul 21 | r05        | Stamford AFCStamford AFC | 1 - 3 | Kettering TownKettering Tow |
| 22 Jul 21 | r05        | Makedonija GjPMakedonija Gj | 2 - 1 | Akademija PandevAkademija Pan |
| 22 Jul 21 | r05        | RadRad | 0 - 3 | Hapoel Kiryat ShmonaHapoel Kiryat |
| 22 Jul 21 | r05        | ChelseaChelsea | - | DroghedaDrogheda |
| 23 Jul 21 | r05        | LeverkusenLeverkusen | 0 - 0 | FreiburgFreiburg |
| 23 Jul 21 | r05        | StuttgartStuttgart | 5 - 2 | BielefeldBielefeld |
| 23 Jul 21 | r05        | TernanaTernana | 3 - 0 | FC Grosseto SSDFC Grosseto S |
| 23 Jul 21 | r05        | NumanciaNumancia | 1 - 1 | Ath MadridAth Madrid |
| 23 Jul 21 | r05        | Dynamo KievDynamo Kiev | 1 - 1 | Union BerlinUnion Berlin |
| 23 Jul 21 | r05        | Celta VigoCelta Vigo | 3 - 0 | Atlético SanluqueñoAtlético Sanl |
| 23 Jul 21 | r05        | AtalantaAtalanta | - | ModenaModena |
| 23 Jul 21 | r05        | PAEEKPAEEK | - | OnisilosOnisilos |
| 23 Jul 21 | r05        | Arka GdyniaArka Gdynia | 3 - 1 | Hapoel Tel-AvivHapoel Tel-Av |
| 23 Jul 21 | r05        | Stade BriochinStade Briochi | - | ConcarneauConcarneau |
| 23 Jul 21 | r05        | SantanderSantander | - | Sp Gijon BSp Gijon B |
| 23 Jul 21 | r05        | Ath MadridAth Madrid | 2 - 1 | NumanciaNumancia |
| 23 Jul 21 | r05        | Cambridge UnitedCambridge Uni | 1 - 3 | BrentfordBrentford |
| 23 Jul 21 | r05        | Mosta FCMosta FC | - | Balzan FCBalzan FC |
| 23 Jul 21 | r05        | StevenageStevenage | 1 - 0 | Crystal PalaceCrystal Palac |
| 23 Jul 21 | r05        | Alfreton TownAlfreton Town | 1 - 2 | MansfieldMansfield |
| 24 Jul 21 | r05        | AccringtonAccrington | 1 - 1 | PrestonPreston |
| 24 Jul 21 | r05        | Bath CityBath City | 3 - 3 | Gloucester CityGloucester Ci |
| 24 Jul 21 | r05        | Haringey BoroughHaringey Boro | 0 - 4 | Oxford CityOxford City |
| 24 Jul 21 | r05        | Crusaders Crusaders | 3 - 1 | H and W WeldersH and W Welde |
| 24 Jul 21 | r05        | MilanMilan | 5 - 0 | ModenaModena |
| 24 Jul 21 | r05        | PisaPisa | 1 - 1 | CremoneseCremonese |
| 24 Jul 21 | r05        | Jong VolendamJong Volendam | 6 - 1 | Jong AZJong AZ |
| 24 Jul 21 | r05        | ChelmsfordChelmsford | 1 - 1 | Boreham WoodBoreham Wood |
| 24 Jul 21 | r05        | ColchesterColchester | 0 - 2 | GillinghamGillingham |
| 24 Jul 21 | r05        | NapoliNapoli | 1 - 0 | Pro VercelliPro Vercelli |
| 24 Jul 21 | r05        | BresciaBrescia | 1 - 2 | RenateRenate |
| 24 Jul 21 | r05        | Aris LimassolAris Limassol | 0 - 1 | Hapoel JerusalemHapoel Jerusa |
| 24 Jul 21 | r05        | Zalaegerszegi TEZalaegerszegi | 0 - 0 | AEK LarnacaAEK Larnaca |
| 24 Jul 21 | r05        | BadajozBadajoz | 2 - 1 | Benfica BBenfica B |
| 24 Jul 21 | r05        | ExtremaduraExtremadura | 0 - 3 | FC Porto BFC Porto B |
| 24 Jul 21 | r05        | EspanolEspanol | 0 - 2 | VallecanoVallecano |
| 24 Jul 21 | r05        | Ripensia TimisoaraRipensia Timi | 0 - 2 | FC Politehnica TimisoaraFC Politehnic |
| 24 Jul 21 | r05        | CSA Steaua BucureştiCSA Steaua Bu | 3 - 0 | Unirea ConstanțaUnirea Consta |
| 24 Jul 21 | r05        | SesveteSesvete | 0 - 1 | KustošijaKustošija |
| 24 Jul 21 | r05        | SocuéllamosSocuéllamos | 1 - 4 | Linares DeportivoLinares Depor |
| 24 Jul 21 | r05        | SD AmorebietaSD Amorebieta | 1 - 1 | UD LogroñésUD Logroñés |
| 24 Jul 21 | r05        | Osasuna BOsasuna B | 1 - 0 | SD LogroñésSD Logroñés |
| 24 Jul 21 | r05        | B.93B.93 | 4 - 0 | FA 2000FA 2000 |
| 24 Jul 21 | r05        | AB GladsaxeAB Gladsaxe | 0 - 4 | Næstved BKNæstved BK |
| 24 Jul 21 | r05        | Kickers OffenbachKickers Offen | 5 - 1 | Bergisch Gladbach 09Bergisch Glad |
| 24 Jul 21 | r05        | MonzaMonza | 3 - 0 | Pro SestoPro Sesto |
| 24 Jul 21 | r05        | Blyth SpartansBlyth Spartan | 1 - 2 | South ShieldsSouth Shields |
| 24 Jul 21 | r05        | Eastbourne BoroughEastbourne Bo | 1 - 2 | KingstonianKingstonian |
| 24 Jul 21 | r05        | Hyde UnitedHyde United | 4 - 4 | Bradford Park AvenueBradford Park |
| 24 Jul 21 | r05        | StalybridgeStalybridge | 1 - 2 | CurzonCurzon |
| 24 Jul 21 | r05        | PerugiaPerugia | 6 - 0 | Montevarchi Calcio AquilaMontevarchi C |
| 24 Jul 21 | r05        | Ħamrun SpartansĦamrun Sparta | 2 - 1 | Balzan FCBalzan FC |
| 24 Jul 21 | r05        | JuventusJuventus | 3 - 1 | CesenaCesena |
| 24 Jul 21 | r05        | Mačva ŠabacMačva Šabac | 2 - 1 | Bačka PalankaBačka Palanka |
| 24 Jul 21 | r05        | Sirens FCSirens FC | 0 - 1 | Floriana FCFloriana FC |
| 24 Jul 21 | r05        | VitesseVitesse | 0 - 1 | Lommel SKLommel SK |
| 24 Jul 21 | r05        | PetrolulPetrolul | 2 - 1 | ConcordiaConcordia |
| 24 Jul 21 | r05        | RecreativoRecreativo | 0 - 1 | Betis DeportivoBetis Deporti |
| 24 Jul 21 | r05        | BrønshøjBrønshøj | 0 - 4 | RoskildeRoskilde |
| 24 Jul 21 | r05        | HillerødHillerød | 1 - 1 | FremFrem |
| 24 Jul 21 | r05        | SioniSioni | 3 - 0 | Metalurgi RustaviMetalurgi Rus |
| 24 Jul 21 | r05        | Al AinAl Ain | 0 - 1 | UCAM MurciaUCAM Murcia |
| 24 Jul 21 | r05        | FC HermannstadtFC Hermannsta | 1 - 1 | 1599 Șelimbăr1599 Șelimbăr |
| 24 Jul 21 | r05        | BrestBrest | 1 - 3 | NantesNantes |
| 24 Jul 21 | r05        | Stuttgart IIStuttgart II | 1 - 4 | Bahlinger SCBahlinger SC |
| 24 Jul 21 | r05        | OsasunaOsasuna | 2 - 0 | BurgosBurgos |
| 24 Jul 21 | r05        | MiddelfartMiddelfart | - | Hellerup IKHellerup IK |
| 24 Jul 21 | r05        | Radomiak RadomRadomiak Rado | 2 - 1 | BełchatówBełchatów |
| 24 Jul 21 | r05        | Skive IKSkive IK | 0 - 2 | VSK ÅrhusVSK Århus |
| 24 Jul 21 | r05        | LensLens | 2 - 1 | Stade de ReimsStade de Reim |
| 24 Jul 21 | r05        | ArsenalArsenal | 4 - 1 | MillwallMillwall |
| 24 Jul 21 | r05        | ADO Den HaagADO Den Haag | 2 - 2 | FC TwenteFC Twente |
| 24 Jul 21 | r05        | BarnetBarnet | 2 - 3 | PeterboroPeterboro |
| 24 Jul 21 | r05        | Atlas DelmenhorstAtlas Delmenh | 4 - 1 | Bremer SVBremer SV |
| 24 Jul 21 | r05        | Brighouse TownBrighouse Tow | 2 - 3 | MatlockMatlock |
| 24 Jul 21 | r05        | ChorleyChorley | 0 - 2 | Dorking WanderersDorking Wande |
| 24 Jul 21 | r05        | Needham MarketNeedham Marke | 2 - 0 | Brightlingsea RegentBrightlingsea |
| 24 Jul 21 | r05        | Union BerlinUnion Berlin | 2 - 0 | NiceNice |
| 24 Jul 21 | r05        | East Thurrock UnitedEast Thurrock | - | Concord RangersConcord Range |
| 24 Jul 21 | r05        | Kidderminster HarriersKidderminster | 0 - 5 | WalsallWalsall |
| 24 Jul 21 | r05        | LorientLorient | - | BordeauxBordeaux |
| 24 Jul 21 | r05        | RenovaRenova | - | EgnatiaEgnatia |
| 24 Jul 21 | r05        | FenerbahceFenerbahce | - | UdineseUdinese |
| 24 Jul 21 | r05        | SpeziaSpezia | - | LecceLecce |
| 24 Jul 21 | r05        | RegginaReggina | - | SambenedetteseSambenedettes |
| 24 Jul 21 | r05        | DiosgyorDiosgyor | 1 - 1 | Al HazmAl Hazm |
| 24 Jul 21 | r05        | IMT Novi BeogradIMT Novi Beog | 0 - 2 | Al FeihaAl Feiha |
| 24 Jul 21 | r05        | Parma Calcio 1913Parma Calcio | 4 - 2 | TrentoTrento |
| 24 Jul 21 | r05        | Szombathelyi HaladásSzombathelyi | - | SiófokSiófok |
| 24 Jul 21 | r05        | OrleansOrleans | - | LavalLaval |
| 24 Jul 21 | r05        | Jeunesse EschJeunesse Esch | 2 - 2 | Swift HesperangeSwift Hespera |
| 24 Jul 21 | r05        | Le MansLe Mans | 3 - 1 | FC Versailles 78FC Versailles |
| 24 Jul 21 | r05        | AlavesAlaves | 1 - 3 | SociedadSociedad |
| 24 Jul 21 | r05        | Paris SGParis SG | - | GenoaGenoa |
| 24 Jul 21 | r05        | BragaBraga | - | F.C. Paços de FerreiraF.C. Paços de |
| 25 Jul 21 | r05        | Szombathelyi HaladásSzombathelyi | 1 - 3 | SiófokSiófok |
| 25 Jul 21 | r05        | StrugaStruga | 2 - 0 | GjilaniGjilani |
| 25 Jul 21 | r05        | SalernitanaSalernitana | 0 - 1 | GubbioGubbio |
| 25 Jul 21 | r05        | AntalyasporAntalyaspor | 4 - 1 | Menemen BelediyesporMenemen Beled |
| 25 Jul 21 | r05        | ErzurumsporErzurumspor | 1 - 2 | KonyasporKonyaspor |
| 25 Jul 21 | r05        | AZ AlkmaarAZ Alkmaar | 3 - 0 | PanathinaikosPanathinaikos |
| 25 Jul 21 | r05        | GoztepeGoztepe | 1 - 1 | ÜmraniyesporÜmraniyespor |
| 25 Jul 21 | r05        | LamiaLamia | 2 - 2 | Ethnikos AchnaEthnikos Achn |
| 25 Jul 21 | r05        | Sp GijonSp Gijon | 2 - 0 | Racing Club de FerrolRacing Club d |
| 25 Jul 21 | r05        | BadajozBadajoz | 0 - 1 | FC Porto BFC Porto B |
| 25 Jul 21 | r05        | VasasVasas | 2 - 2 | SoroksárSoroksár |
| 25 Jul 21 | r05        | DEACDEAC | 1 - 0 | BékéscsabaBékéscsaba |
| 25 Jul 21 | r05        | SO CholetSO Cholet | 0 - 1 | Voltigeurs de ChâteaubriaVoltigeurs de |
| 25 Jul 21 | r05        | AtalantaAtalanta | - | PergolettesePergolettese |
| 25 Jul 21 | r05        | FC 03 Differdange FC 03 Differd | 3 - 2 | RodangeRodange |
| 25 Jul 21 | r05        | Dynamo KievDynamo Kiev | 3 - 2 | Gaziantep FKGaziantep FK |
| 25 Jul 21 | r05        | FiorentinaFiorentina | - | A.S.D. Città di Foligno 1A.S.D. Città |
| 25 Jul 21 | r05        | Podbeskidzie Bielsko-BialPodbeskidzie | - | GoricaGorica |
| 25 Jul 21 | r05        | PotenzaPotenza | 0 - 3 | SSD PalermoSSD Palermo |
| 25 Jul 21 | r05        | ArsenalArsenal | - | InterInter |
| 25 Jul 21 | r05        | EvertonEverton | 2 - 1 | Millonarios F.C.Millonarios F |
| 25 Jul 21 | r05        | EvertonEverton | 1 - 1 | Millonarios F.C.Millonarios F |
| 26 Jul 21 | r05        | GenclerbirligiGenclerbirlig | 0 - 4 | FenerbahceFenerbahce |
| 26 Jul 21 | r05        | SampdoriaSampdoria | 2 - 0 | PiacenzaPiacenza |
| 26 Jul 21 | r05        | Las PalmasLas Palmas | 3 - 2 | WolvesWolves |
| 26 Jul 21 | r05        | HendonHendon | 2 - 0 | Hampton & RichmondHampton & Ric |
| 27 Jul 21 | r05        | YorkYork | 2 - 1 | MiddlesbroughMiddlesbrough |
| 27 Jul 21 | r05        | BesiktasBesiktas | 1 - 0 | Istanbul BasaksehirIstanbul Basa |
| 27 Jul 21 | r05        | Manchester CityManchester Ci | 2 - 0 | PrestonPreston |
| 27 Jul 21 | r05        | CadizCadiz | 0 - 2 | Las PalmasLas Palmas |
| 27 Jul 21 | r05        | GranadaGranada | 1 - 1 | EspanolEspanol |
| 27 Jul 21 | r05        | Cliftonville Cliftonville | 3 - 2 | ArdsArds |
| 27 Jul 21 | r05        | StourbridgeStourbridge | 0 - 1 | Solihull MoorsSolihull Moor |
| 27 Jul 21 | r05        | BournemouthBournemouth | 1 - 2 | ChelseaChelsea |
| 27 Jul 21 | r05        | Armagh CityArmagh City | 0 - 1 | Warrenpoint TownWarrenpoint T |
| 27 Jul 21 | r05        | KayserisporKayserispor | 1 - 1 | BallkaniBallkani |
| 27 Jul 21 | r05        | MainzMainz | 1 - 0 | Gaziantep FKGaziantep FK |
| 27 Jul 21 | r05        | Blyth SpartansBlyth Spartan | 2 - 1 | HartlepoolHartlepool |
| 27 Jul 21 | r05        | KarlslundeKarlslunde | 1 - 1 | FA 2000FA 2000 |
| 27 Jul 21 | r05        | OsnabrueckOsnabrueck | 9 - 0 | Sportfreunde LotteSportfreunde |
| 27 Jul 21 | r05        | Tabor SežanaTabor Sežana | - | FenerbahceFenerbahce |
| 27 Jul 21 | r05        | AnnecyAnnecy | 3 - 0 | Besançon FootballBesançon Foot |
| 27 Jul 21 | r05        | RabotnichkiRabotnichki | 0 - 0 | GjilaniGjilani |
| 27 Jul 21 | r05        | Apoel NicosiaApoel Nicosia | 4 - 0 | Pirin BlagoevgradPirin Blagoev |
| 27 Jul 21 | r05        | SamsunsporSamsunspor | 2 - 1 | BursasporBursaspor |
| 27 Jul 21 | r05        | FremFrem | - | FC HelsingoerFC Helsingoer |
| 27 Jul 21 | r05        | Al FeihaAl Feiha | 3 - 2 | AjmanAjman |
| 27 Jul 21 | r05        | Vannes OCVannes OC | 1 - 1 | Stade BriochinStade Briochi |
| 27 Jul 21 | r05        | Hessen KasselHessen Kassel | 0 - 0 | KSV BaunatalKSV Baunatal |
| 27 Jul 21 | r05        | Stade PlabennécoisStade Plabenn | 3 - 2 | ConcarneauConcarneau |
| 27 Jul 21 | r05        | Oxford UtdOxford Utd | - | PeterboroPeterboro |
| 27 Jul 21 | r05        | Cartagena FCCartagena FC | 1 - 1 | Al-Nasr SalalahAl-Nasr Salal |
| 27 Jul 21 | r05        | SevillaSevilla | 2 - 2 | Paris SGParis SG |
| 27 Jul 21 | r05        | DollingstownDollingstown | 1 - 1 | LoughgallLoughgall |
| 27 Jul 21 | r05        | ChorleyChorley | 0 - 1 | BoltonBolton |
| 27 Jul 21 | r05        | WorthingWorthing | 5 - 1 | Welling UnitedWelling Unite |
| 27 Jul 21 | r05        | Whitby TownWhitby Town | 0 - 2 | Spennymoor Town FCSpennymoor To |
| 27 Jul 21 | r05        | ChelseaChelsea | - | BournemouthBournemouth |
| 27 Jul 21 | r05        | SouthportSouthport | 2 - 0 | MarineMarine |
| 27 Jul 21 | r05        | Stafford RangersStafford Rang | 3 - 1 | Hednesford TownHednesford To |
| 27 Jul 21 | r05        | Dorchester TownDorchester To | 0 - 3 | Hungerford TownHungerford To |
| 28 Jul 21 | r05        | EmpoliEmpoli | 3 - 0 | PontederaPontedera |
| 28 Jul 21 | r05        | AlavesAlaves | 1 - 0 | MirandesMirandes |
| 28 Jul 21 | r05        | FC PortoFC Porto | 1 - 1 | RomaRoma |
| 28 Jul 21 | r05        | LamiaLamia | 0 - 1 | Apollon SmirnisApollon Smirn |
| 28 Jul 21 | r05        | AlessandriaAlessandria | 4 - 1 | RenateRenate |
| 28 Jul 21 | r05        | FenerbahceFenerbahce | 2 - 2 | PEC ZwollePEC Zwolle |
| 28 Jul 21 | r05        | CompostelaCompostela | 0 - 3 | LugoLugo |
| 28 Jul 21 | r05        | AltayAltay | 3 - 0 | GiresunsporGiresunspor |
| 28 Jul 21 | r05        | AntalyasporAntalyaspor | 1 - 1 | ÜmraniyesporÜmraniyespor |
| 28 Jul 21 | r05        | InterInter | 6 - 0 | CrotoneCrotone |
| 28 Jul 21 | r05        | UdineseUdinese | 2 - 3 | Sturm GrazSturm Graz |
| 28 Jul 21 | r05        | BellinzonaBellinzona | 1 - 0 | LuganoLugano |
| 28 Jul 21 | r05        | FrosinoneFrosinone | 1 - 2 | ViterbeseViterbese |
| 28 Jul 21 | r05        | Türkgücü MünchenTürkgücü Münc | 1 - 0 | Sonnenhof GroßaspachSonnenhof Gro |
| 28 Jul 21 | r05        | Anorthosis FamagustaAnorthosis Fa | 4 - 1 | PAEEKPAEEK |
| 28 Jul 21 | r05        | FC GießenFC Gießen | 0 - 3 | Wuppertaler SVWuppertaler S |
| 28 Jul 21 | r05        | Sp GijonSp Gijon | 0 - 2 | Real Sociedad BReal Sociedad |
| 28 Jul 21 | r05        | ElversbergElversberg | 4 - 1 | Eintracht TrierEintracht Tri |
| 28 Jul 21 | r05        | GranadaGranada | 0 - 1 | AlcorconAlcorcon |
| 28 Jul 21 | r05        | UCAM MurciaUCAM Murcia | 0 - 1 | CA PulpileñoCA Pulpileño |
| 28 Jul 21 | r05        | RenovaRenova | 2 - 2 | VardarVardar |
| 28 Jul 21 | r05        | AugsburgAugsburg | - | SPVGG Greuther FürthSPVGG Greuthe |
| 28 Jul 21 | r05        | SioniSioni | - | SamguraliSamgurali |
| 28 Jul 21 | r05        | KonyasporKonyaspor | - | GoztepeGoztepe |
| 28 Jul 21 | r05        | ArsenalArsenal | 4 - 1 | WatfordWatford |
| 28 Jul 21 | r05        | Beitar Tel Aviv Bat YamBeitar Tel Av | 1 - 3 | Hapoel Ramat GanHapoel Ramat |
| 28 Jul 21 | r05        | Olympiakos NicosiaOlympiakos Ni | 6 - 1 | OnisilosOnisilos |
| 28 Jul 21 | r05        | ViterbeseViterbese | - | FrosinoneFrosinone |
| 28 Jul 21 | r05        | Saburtalo TbilisiSaburtalo Tbi | 2 - 1 | Sabah FCSabah FC |
| 28 Jul 21 | r05        | EntellaEntella | - | SC Ligorna 1922SC Ligorna 19 |
| 28 Jul 21 | r05        | SkenderbeuSkenderbeu | 1 - 3 | GjilaniGjilani |
| 28 Jul 21 | r05        | SD AmorebietaSD Amorebieta | - | Osasuna BOsasuna B |
| 28 Jul 21 | r05        | Dinamo Zagreb IIDinamo Zagreb | 2 - 1 | MeđimurjeMeđimurje |
| 28 Jul 21 | r05        | HerthaHertha | - | VillarrealVillarreal |
| 28 Jul 21 | r05        | Real OviedoReal Oviedo | 1 - 2 | LeonesaLeonesa |
| 28 Jul 21 | r05        | CoventryCoventry | - | NorwichNorwich |
| 28 Jul 21 | r05        | SD LogroñésSD Logroñés | - | BurgosBurgos |
| 28 Jul 21 | r05        | San Roque LepeSan Roque Lep | 0 - 0 | Sevilla AtleticoSevilla Atlet |
| 28 Jul 21 | r05        | Bognor Regis TownBognor Regis | - | PortsmouthPortsmouth |
| 28 Jul 21 | r05        | MarseilleMarseille | 2 - 1 | St EtienneSt Etienne |
| 28 Jul 21 | r05        | EvertonEverton | 1 - 0 | PumasPumas |
| 29 Jul 21 | r05        | VeronaVerona | 3 - 2 | ModenaModena |
| 29 Jul 21 | r05        | BeneventoBenevento | 3 - 1 | RegginaReggina |
| 29 Jul 21 | r05        | PisaPisa | 1 - 0 | Pro SestoPro Sesto |
| 29 Jul 21 | r05        | SalernitanaSalernitana | 1 - 0 | FermanaFermana |
| 29 Jul 21 | r05        | Kickers OffenbachKickers Offen | 1 - 4 | Rot-Weiss EssenRot-Weiss Ess |
| 29 Jul 21 | r05        | VillarrealVillarreal | 0 - 0 | LevanteLevante |
| 29 Jul 21 | r05        | Staines TownStaines Town | 0 - 6 | Maidenhead UnitedMaidenhead Un |
| 29 Jul 21 | r05        | DalumDalum | 4 - 1 | SfB-OureSfB-Oure |
| 29 Jul 21 | r05        | Millonarios F.C.Millonarios F | 2 - 3 | Atlético NacionalAtlético Naci |
| 29 Jul 21 | r05        | AndorraAndorra | 2 - 0 | Villarreal BVillarreal B |
| 29 Jul 21 | r05        | Locomotive TbilisiLocomotive Tb | 2 - 0 | Sabail FKSabail FK |
| 29 Jul 21 | r05        | VitesseVitesse | - | BochumBochum |
| 29 Jul 21 | r05        | L.R. Vicenza VirtusL.R. Vicenza | - | Virtus VeronaVirtus Verona |
| 29 Jul 21 | r05        | SSD PalermoSSD Palermo | 1 - 0 | MonopoliMonopoli |
| 29 Jul 21 | r05        | Algeciras CFAlgeciras CF | 2 - 3 | Al ShababAl Shabab |
| 30 Jul 21 | r05        | Brabrand IFBrabrand IF | 1 - 0 | Skive IKSkive IK |
| 30 Jul 21 | r05        | Næstved BKNæstved BK | 5 - 3 | B.93B.93 |
| 30 Jul 21 | r05        | Hyde UnitedHyde United | 2 - 0 | GrimsbyGrimsby |
| 30 Jul 21 | r05        | L.R. Vicenza VirtusL.R. Vicenza | 0 - 1 | LecceLecce |
| 30 Jul 21 | r05        | Haro DeportivoHaro Deportiv | 2 - 1 | Racing Rioja CFRacing Rioja |
| 30 Jul 21 | r05        | FremFrem | 0 - 2 | RoskildeRoskilde |
| 30 Jul 21 | r05        | CadizCadiz | 0 - 2 | EspanolEspanol |
| 30 Jul 21 | r05        | Aris LimassolAris Limassol | 0 - 2 | Doxa KatokopiasDoxa Katokopi |
| 30 Jul 21 | r05        | União de LeiriaUnião de Leir | 1 - 1 | AnadiaAnadia |
| 30 Jul 21 | r05        | SampdoriaSampdoria | - | SpeziaSpezia |
| 30 Jul 21 | r05        | StrugaStruga | 2 - 1 | MalishevaMalisheva |
| 30 Jul 21 | r05        | EspanolEspanol | - | CadizCadiz |
| 30 Jul 21 | r05        | FC VillefrancheFC Villefranc | 1 - 1 | Thonon Évian F.C.Thonon Évian |
| 30 Jul 21 | r05        | HerthaHertha | 3 - 2 | Al HilalAl Hilal |
| 30 Jul 21 | r05        | Les Herbiers VFLes Herbiers | 0 - 1 | SO CholetSO Cholet |
| 30 Jul 21 | r05        | Torpedo KutaisiTorpedo Kutai | 3 - 1 | ShukuraShukura |
| 30 Jul 21 | r05        | ConcarneauConcarneau | 0 - 1 | Vannes OCVannes OC |
| 30 Jul 21 | r05        | Rot Weiss AhlenRot Weiss Ahl | 1 - 1 | Rot-Weiß ErfurtRot-Weiß Erfu |
| 30 Jul 21 | r05        | Bremer SVBremer SV | 3 - 3 | VfL OldenburgVfL Oldenburg |
| 30 Jul 21 | r05        | ValenciaValencia | - | LevanteLevante |
| 30 Jul 21 | r05        | Bourg-PeronnasBourg-Peronna | 1 - 1 | AnnecyAnnecy |
| 30 Jul 21 | r05        | FC ChamblyFC Chambly | 3 - 0 | FC Fleury 91FC Fleury 91 |
| 30 Jul 21 | r05        | CreteilCreteil | 0 - 0 | Red StarRed Star |
| 30 Jul 21 | r05        | LavalLaval | 1 - 0 | US Lusitanos Saint-MaurUS Lusitanos |
| 30 Jul 21 | r05        | BoulogneBoulogne | 2 - 1 | FC Versailles 78FC Versailles |
| 30 Jul 21 | r05        | YeclanoYeclano | 1 - 1 | UCAM MurciaUCAM Murcia |
| 30 Jul 21 | r05        | SunderlandSunderland | - | HullHull |
| 30 Jul 21 | r05        | Chippenham Town FCChippenham To | - | Taunton TownTaunton Town |
| 31 Jul 21 | r05        | Ein FrankfurtEin Frankfurt | 2 - 1 | St EtienneSt Etienne |
| 31 Jul 21 | r05        | LensLens | 4 - 1 | UdineseUdinese |
| 31 Jul 21 | r05        | RomaRoma | 0 - 0 | SevillaSevilla |
| 31 Jul 21 | r05        | LeedsLeeds | 2 - 3 | BetisBetis |
| 31 Jul 21 | r05        | Fortuna KölnFortuna Köln | 4 - 2 | Schott MainzSchott Mainz |
| 31 Jul 21 | r05        | Hessen KasselHessen Kassel | 0 - 1 | VfV HildesheimVfV Hildeshei |
| 31 Jul 21 | r05        | ReadingReading | 1 - 3 | Crystal PalaceCrystal Palac |
| 31 Jul 21 | r05        | AtalantaAtalanta | 2 - 1 | Pordenone CalcioPordenone Cal |
| 31 Jul 21 | r05        | FrosinoneFrosinone | 2 - 0 | TernanaTernana |
| 31 Jul 21 | r05        | BelasicaBelasica | 1 - 1 | BorecBorec |
| 31 Jul 21 | r05        | BesiktasBesiktas | 0 - 3 | KayserisporKayserispor |
| 31 Jul 21 | r05        | StuttgartStuttgart | 0 - 3 | BarcelonaBarcelona |
| 31 Jul 21 | r05        | WolfsburgWolfsburg | 1 - 2 | Ath MadridAth Madrid |
| 31 Jul 21 | r05        | FC PortoFC Porto | 5 - 3 | LyonLyon |
| 31 Jul 21 | r05        | MonzaMonza | 1 - 2 | JuventusJuventus |
| 31 Jul 21 | r05        | Weiche Flensburg 08Weiche Flensb | 1 - 1 | Kolding IFKolding IF |
| 31 Jul 21 | r05        | BrentfordBrentford | 0 - 1 | West HamWest Ham |
| 31 Jul 21 | r05        | ChesterfieldChesterfield | 0 - 1 | Port ValePort Vale |
| 31 Jul 21 | r05        | OsasunaOsasuna | 1 - 0 | MirandesMirandes |
| 31 Jul 21 | r05        | PortstewartPortstewart | 1 - 3 | Cliftonville Cliftonville |
| 31 Jul 21 | r05        | Ballinamallard UnitedBallinamallar | 3 - 0 | Warrenpoint TownWarrenpoint T |
| 31 Jul 21 | r05        | ColeraineColeraine | 5 - 0 | DergviewDergview |
| 31 Jul 21 | r05        | ExeterExeter | 0 - 2 | ShrewsburyShrewsbury |
| 31 Jul 21 | r05        | FenerbahceFenerbahce | 3 - 2 | SPVGG Greuther FürthSPVGG Greuthe |
| 31 Jul 21 | r05        | FC UtrechtFC Utrecht | 2 - 3 | VeneziaVenezia |
| 31 Jul 21 | r05        | CremoneseCremonese | 2 - 1 | FeralpisalòFeralpisalò |
| 31 Jul 21 | r05        | MalagaMalaga | 0 - 3 | AlcorconAlcorcon |
| 31 Jul 21 | r05        | TudelanoTudelano | 1 - 3 | UD LogroñésUD Logroñés |
| 31 Jul 21 | r05        | Slagelse B&ISlagelse B&I | 3 - 2 | FA 2000FA 2000 |
| 31 Jul 21 | r05        | AB GladsaxeAB Gladsaxe | 3 - 3 | HerlevHerlev |
| 31 Jul 21 | r05        | Sp Gijon BSp Gijon B | 2 - 2 | Athletic Bilbao BAthletic Bilb |
| 31 Jul 21 | r05        | Wingate & FinchleyWingate & Fin | 0 - 2 | Chesham UnitedChesham Unite |
| 31 Jul 21 | r05        | Lippstadt 08Lippstadt 08 | 1 - 3 | TSV Steinbach HaigerTSV Steinbach |
| 31 Jul 21 | r05        | GiresunsporGiresunspor | 0 - 2 | ÜmraniyesporÜmraniyespor |
| 31 Jul 21 | r05        | BochumBochum | 0 - 2 | FC UtrechtFC Utrecht |
| 31 Jul 21 | r05        | FC KolnFC Koln | 1 - 1 | Roda JCRoda JC |
| 31 Jul 21 | r05        | Hamburg IIHamburg II | 2 - 3 | AachenAachen |
| 31 Jul 21 | r05        | Brackley TownBrackley Town | 2 - 1 | Kettering TownKettering Tow |
| 31 Jul 21 | r05        | Eastbourne BoroughEastbourne Bo | 2 - 3 | LewesLewes |
| 31 Jul 21 | r05        | Havant & WaterloovilleHavant & Wate | 3 - 1 | Gosport BoroughGosport Borou |
| 31 Jul 21 | r05        | Hednesford TownHednesford To | 0 - 0 | LeamingtonLeamington |
| 31 Jul 21 | r05        | NantesNantes | 1 - 2 | Clermont FootClermont Foot |
| 31 Jul 21 | r05        | Ossett UnitedOssett United | 1 - 0 | Grantham TownGrantham Town |
| 31 Jul 21 | r05        | Worksop TownWorksop Town | 0 - 0 | GainsboroughGainsborough |
| 31 Jul 21 | r05        | AscoliAscoli | 2 - 0 | ViterbeseViterbese |
| 31 Jul 21 | r05        | KarmiotissaKarmiotissa | 1 - 4 | Olympiakos NicosiaOlympiakos Ni |
| 31 Jul 21 | r05        | EntellaEntella | 1 - 1 | AlbinoleffeAlbinoleffe |
| 31 Jul 21 | r05        | KustošijaKustošija | 1 - 0 | DubravaDubrava |
| 31 Jul 21 | r05        | LugoLugo | 1 - 1 | Real OviedoReal Oviedo |
| 31 Jul 21 | r05        | Sirens FCSirens FC | 1 - 1 | VallettaValletta |
| 31 Jul 21 | r05        | SPAL 2013SPAL 2013 | 6 - 0 | PontederaPontedera |
| 31 Jul 21 | r05        | ComoComo | 2 - 0 | RenateRenate |
| 31 Jul 21 | r05        | Sp GijonSp Gijon | 1 - 0 | PonferradinaPonferradina |
| 31 Jul 21 | r05        | NumanciaNumancia | 1 - 3 | Osasuna BOsasuna B |
| 31 Jul 21 | r05        | Real UniónReal Unión | 2 - 2 | SantanderSantander |
| 31 Jul 21 | r05        | CalahorraCalahorra | 1 - 3 | SD AmorebietaSD Amorebieta |
| 31 Jul 21 | r05        | CD TeruelCD Teruel | 0 - 0 | Atlético LevanteAtlético Leva |
| 31 Jul 21 | r05        | ExtremaduraExtremadura | 1 - 1 | Sevilla AtleticoSevilla Atlet |
| 31 Jul 21 | r05        | Mačva ŠabacMačva Šabac | 1 - 0 | Radnički Sremska MitrovicRadnički Srem |
| 31 Jul 21 | r05        | CordobaCordoba | 0 - 1 | Linares DeportivoLinares Depor |
| 31 Jul 21 | r05        | CittadellaCittadella | 0 - 0 | TrentoTrento |
| 31 Jul 21 | r05        | GetafeGetafe | 0 - 0 | VallecanoVallecano |
| 31 Jul 21 | r05        | Dinamo Zagreb IIDinamo Zagreb | 2 - 2 | Osijek IIOsijek II |
| 31 Jul 21 | r05        | SabadellSabadell | 3 - 1 | L-'HospitaletL-'Hospitalet |
| 31 Jul 21 | r05        | Al-RaedAl-Raed | 1 - 0 | CF IntercityCF Intercity |
| 31 Jul 21 | r05        | GenkGenk | - | Waasland-BeverenWaasland-Beve |
| 31 Jul 21 | r05        | Celta VigoCelta Vigo | 2 - 0 | Pafos FCPafos FC |
| 31 Jul 21 | r05        | Peña SportPeña Sport | 0 - 2 | SD LogroñésSD Logroñés |
| 31 Jul 21 | r05        | Stuttgart IIStuttgart II | - | Astoria WalldorfAstoria Walld |
| 31 Jul 21 | r05        | WolvesWolves | - | StokeStoke |
| 31 Jul 21 | r05        | Stocksbridge Park SteelsStocksbridge | 1 - 2 | Spennymoor Town FCSpennymoor To |
| 31 Jul 21 | r05        | LeverkusenLeverkusen | - | Celta VigoCelta Vigo |
| 31 Jul 21 | r05        | Cray Valley PMCray Valley P | 1 - 1 | Welling UnitedWelling Unite |
| 31 Jul 21 | r05        | TamworthTamworth | - | WorcesterWorcester |
| 31 Jul 21 | r05        | AjaxAjax | 1 - 1 | RasenBallsport LeipzigRasenBallspor |
| 31 Jul 21 | r05        | Enfield TownEnfield Town | 1 - 7 | Hayes & Yeading UnitedHayes & Yeadi |
| 31 Jul 21 | r05        | HorshamHorsham | 2 - 1 | Metropolitan Police FCMetropolitan |
| 31 Jul 21 | r05        | LutonLuton | 1 - 3 | BrightonBrighton |
| 31 Jul 21 | r05        | WatfordWatford | - | NantesNantes |
| 31 Jul 21 | r05        | Voltigeurs de ChâteaubriaVoltigeurs de | 0 - 1 | Stade BriochinStade Briochi |
| 31 Jul 21 | r05        | SpeziaSpezia | - | Calcio MontebellunaCalcio Monteb |
| 31 Jul 21 | r05        | PevidémPevidém | 0 - 1 | União de LeiriaUnião de Leir |
| 31 Jul 21 | r05        | AlessandriaAlessandria | 1 - 0 | Pro PatriaPro Patria |
| 31 Jul 21 | r05        | Apollon SmirnisApollon Smirn | 1 - 3 | IonikosIonikos |
| 31 Jul 21 | r05        | GuijueloGuijuelo | 2 - 2 | Unionistas de SalamancaUnionistas de |
| 31 Jul 21 | r05        | BadajozBadajoz | 1 - 0 | Salamanca UDSSalamanca UDS |
| 31 Jul 21 | r05        | CD ToledoCD Toledo | 0 - 1 | SS ReyesSS Reyes |
| 31 Jul 21 | r05        | XerezXerez | - | MarbellaMarbella |
| 01 Aug 21 | r05        | Harrogate Town FCHarrogate Tow | 2 - 3 | DoncasterDoncaster |
| 01 Aug 21 | r05        | Bognor Regis TownBognor Regis | 1 - 3 | Dorking WanderersDorking Wande |
| 01 Aug 21 | r05        | GoztepeGoztepe | 3 - 1 | Nazilli BelediyesporNazilli Beled |
| 01 Aug 21 | r05        | KonyasporKonyaspor | 1 - 0 | AntalyasporAntalyaspor |
| 01 Aug 21 | r05        | CatanzaroCatanzaro | 1 - 1 | ViboneseVibonese |
| 01 Aug 21 | r05        | BresciaBrescia | 1 - 0 | MantovaMantova |
| 01 Aug 21 | r05        | Asteras TripolisAsteras Tripo | 4 - 0 | IonikosIonikos |
| 01 Aug 21 | r05        | LamiaLamia | 1 - 3 | PanetolikosPanetolikos |
| 01 Aug 21 | r05        | CadizCadiz | 1 - 2 | AlmeriaAlmeria |
| 01 Aug 21 | r05        | HuescaHuesca | 1 - 0 | CastellónCastellón |
| 01 Aug 21 | r05        | Parma Calcio 1913Parma Calcio | 0 - 3 | SassuoloSassuolo |
| 01 Aug 21 | r05        | PerugiaPerugia | 2 - 0 | CesenaCesena |
| 01 Aug 21 | r05        | LensLens | - | USL DunkerqueUSL Dunkerque |
| 01 Aug 21 | r05        | Notts CountyNotts County | - | DerbyDerby |
| 01 Aug 21 | r05        | WolvesWolves | 2 - 1 | CoventryCoventry |
| 01 Aug 21 | r05        | Almere City FCAlmere City F | - | FC KolnFC Koln |
| 01 Aug 21 | r05        | Kaizer ChiefsKaizer Chiefs | 1 - 0 | Orlando PiratesOrlando Pirat |
| 01 Aug 21 | r05        | AlessandriaAlessandria | - | U.S.D. 1913 Seregno CalciU.S.D. 1913 S |
| 01 Aug 21 | r05        | Arda KardzhaliArda Kardzhal | 2 - 1 | Al Nassr FCAl Nassr FC |
| 01 Aug 21 | r05        | CittadellaCittadella | - | Luparense F.C.Luparense F.C |
| 01 Aug 21 | r05        | Giana ErminioGiana Erminio | 0 - 1 | CrotoneCrotone |
| 01 Aug 21 | r05        | PiacenzaPiacenza | 2 - 3 | PergolettesePergolettese |
| 01 Aug 21 | r05        | SalernitanaSalernitana | 2 - 1 | SSD PalermoSSD Palermo |
| 01 Aug 21 | r05        | Bregalnica ŠtipBregalnica Št | 3 - 0 | SileksSileks |
| 01 Aug 21 | r05        | TenerifeTenerife | 1 - 1 | AlbaceteAlbacete |
| 01 Aug 21 | r05        | ÁguilasÁguilas | 1 - 2 | Al-Nasr SalalahAl-Nasr Salal |
| 01 Aug 21 | r05        | LlagosteraLlagostera | 0 - 2 | GironaGirona |
| 03 Aug 21 | r05        | InstituteInstitute | 0 - 3 | Cliftonville Cliftonville |
| 03 Aug 21 | r05        | FC TwenteFC Twente | 0 - 1 | VeneziaVenezia |
| 03 Aug 21 | r05        | AntalyasporAntalyaspor | 0 - 1 | AltayAltay |
| 03 Aug 21 | r05        | Manchester CityManchester Ci | 4 - 1 | BlackpoolBlackpool |
| 03 Aug 21 | r05        | ExtremaduraExtremadura | 0 - 1 | TalaveraTalavera |
| 03 Aug 21 | r05        | SV TECSV TEC | 2 - 1 | GVVVGVVV |
| 03 Aug 21 | r05        | Fleetwood TownFleetwood Tow | 0 - 4 | WrexhamWrexham |
| 03 Aug 21 | r05        | PanetolikosPanetolikos | 0 - 1 | NFC VolosNFC Volos |
| 03 Aug 21 | r05        | DundelaDundela | 1 - 3 | GlentoranGlentoran |
| 03 Aug 21 | r05        | Warrington TownWarrington To | 1 - 2 | SouthportSouthport |
| 03 Aug 21 | r05        | AveleyAveley | 2 - 4 | LewesLewes |
| 03 Aug 21 | r05        | Brighouse TownBrighouse Tow | 2 - 2 | Farsley CelticFarsley Celti |
| 03 Aug 21 | r05        | Cray Valley PMCray Valley P | 3 - 2 | LeatherheadLeatherhead |
| 03 Aug 21 | r05        | Dulwich HamletDulwich Hamle | 2 - 2 | BromleyBromley |
| 03 Aug 21 | r05        | Faversham TownFaversham Tow | 2 - 1 | MargateMargate |
| 03 Aug 21 | r05        | Hungerford TownHungerford To | 3 - 2 | Swindon SupermarineSwindon Super |
| 03 Aug 21 | r05        | Hyde UnitedHyde United | 2 - 0 | CurzonCurzon |
| 03 Aug 21 | r05        | WittonWitton | 1 - 2 | MarineMarine |
| 03 Aug 21 | r05        | StockportStockport | - | LincolnLincoln |
| 03 Aug 21 | r05        | CibaliaCibalia | 2 - 2 | Osijek IIOsijek II |
| 03 Aug 21 | r05        | Celta VigoCelta Vigo | 0 - 0 | Gil VicenteGil Vicente |
| 03 Aug 21 | r05        | Hannoverscher SCHannoverscher | 1 - 1 | Sportfreunde LotteSportfreunde |
| 03 Aug 21 | r05        | NK Inter ZaprešićNK Inter Zapr | 2 - 1 | Dinamo Zagreb IIDinamo Zagreb |
| 03 Aug 21 | r05        | OlotOlot | 1 - 3 | Barcelona BBarcelona B |
| 03 Aug 21 | r05        | Unionistas de SalamancaUnionistas de | 3 - 0 | Leganés IILeganés II |
| 03 Aug 21 | r05        | Ossett UnitedOssett United | 0 - 1 | YorkYork |
| 03 Aug 21 | r05        | StalybridgeStalybridge | - | RochdaleRochdale |
| 03 Aug 21 | r05        | Cray WanderersCray Wanderer | 2 - 2 | Welling UnitedWelling Unite |
| 03 Aug 21 | r05        | TamworthTamworth | 3 - 1 | BirminghamBirmingham |
| 03 Aug 21 | r05        | St Albans CitySt Albans Cit | 2 - 0 | HendonHendon |
| 04 Aug 21 | r05        | SV SalzburgSV Salzburg | 2 - 1 | BarcelonaBarcelona |
| 04 Aug 21 | r05        | ValladolidValladolid | 3 - 1 | VallecanoVallecano |
| 04 Aug 21 | r05        | FenerbahceFenerbahce | 1 - 1 | Dynamo KievDynamo Kiev |
| 04 Aug 21 | r05        | HuescaHuesca | 1 - 0 | MallorcaMallorca |
| 04 Aug 21 | r05        | ValenciaValencia | 0 - 0 | MilanMilan |
| 04 Aug 21 | r05        | ZaragozaZaragoza | 0 - 0 | GetafeGetafe |
| 04 Aug 21 | r05        | BelenensesBelenenses | 1 - 3 | RomaRoma |
| 04 Aug 21 | r05        | LamiaLamia | 2 - 0 | GianninaGiannina |
| 04 Aug 21 | r05        | CittadellaCittadella | 2 - 0 | Virtus VeronaVirtus Verona |
| 04 Aug 21 | r05        | Wisla KrakowWisla Krakow | 1 - 2 | NapoliNapoli |
| 04 Aug 21 | r05        | DürenDüren | 3 - 3 | Fortuna KölnFortuna Köln |
| 04 Aug 21 | r05        | CadizCadiz | 1 - 1 | Ath MadridAth Madrid |
| 04 Aug 21 | r05        | SouthamptonSouthampton | 1 - 0 | LevanteLevante |
| 04 Aug 21 | r05        | LeicesterLeicester | 3 - 2 | VillarrealVillarreal |
| 04 Aug 21 | r05        | Fortuna Düsseldorf IIFortuna Düsse | 0 - 1 | Mainz IIMainz II |
| 04 Aug 21 | r05        | Asteras TripolisAsteras Tripo | 4 - 0 | Apollon SmirnisApollon Smirn |
| 04 Aug 21 | r05        | Calcio PadovaCalcio Padova | 2 - 2 | Pordenone CalcioPordenone Cal |
| 04 Aug 21 | r05        | Sp Gijon BSp Gijon B | 3 - 2 | MarinoMarino |
| 04 Aug 21 | r05        | CornellàCornellà | 1 - 0 | Villarreal BVillarreal B |
| 04 Aug 21 | r05        | UCAM MurciaUCAM Murcia | 3 - 0 | Racing MurciaRacing Murcia |
| 04 Aug 21 | r05        | Chester CityChester City | 0 - 0 | BoltonBolton |
| 04 Aug 21 | r05        | GimnasticGimnastic | 4 - 1 | Atlético LevanteAtlético Leva |
| 04 Aug 21 | r05        | CordobaCordoba | 4 - 3 | MarbellaMarbella |
| 04 Aug 21 | r05        | SS ReyesSS Reyes | 0 - 1 | AlcorconAlcorcon |
| 04 Aug 21 | r05        | OsasunaOsasuna | 2 - 0 | UD LogroñésUD Logroñés |
| 04 Aug 21 | r05        | AjaxAjax | - | LeedsLeeds |
| 04 Aug 21 | r05        | MonzaMonza | 1 - 1 | Pro PatriaPro Patria |
| 04 Aug 21 | r05        | Aris LimassolAris Limassol | - | KarmiotissaKarmiotissa |
| 04 Aug 21 | r05        | BetisBetis | 1 - 2 | AlmeriaAlmeria |
| 04 Aug 21 | r05        | Schwarz-Weiß RehdenSchwarz-Weiß | - | Rot-Weiss EssenRot-Weiss Ess |
| 04 Aug 21 | r05        | BergantiñosBergantiños | 2 - 1 | La CorunaLa Coruna |
| 04 Aug 21 | r05        | SouthendSouthend | 2 - 3 | BrentfordBrentford |
| 04 Aug 21 | r05        | Zamora F.C.Zamora F.C. | 0 - 3 | PonferradinaPonferradina |
| 04 Aug 21 | r05        | LaredoLaredo | - | CD VitoriaCD Vitoria |
| 05 Aug 21 | r05        | East Thurrock UnitedEast Thurrock | 1 - 3 | MaidstoneMaidstone |
| 05 Aug 21 | r05        | GoztepeGoztepe | 3 - 2 | Menemen BelediyesporMenemen Beled |
| 05 Aug 21 | r05        | AlessandriaAlessandria | 5 - 1 | Fossano Calcio SSDFossano Calci |
| 05 Aug 21 | r05        | Ethnikos AchnaEthnikos Achn | 3 - 1 | Olympiakos NicosiaOlympiakos Ni |
| 05 Aug 21 | r05        | Atlético BalearesAtlético Bale | 0 - 1 | Algeciras CFAlgeciras CF |
| 05 Aug 21 | r05        | Grantham TownGrantham Town | 2 - 3 | Kettering TownKettering Tow |
| 05 Aug 21 | r05        | LiverpoolLiverpool | 2 - 0 | BolognaBologna |
| 05 Aug 21 | r05        | GjilaniGjilani | 2 - 0 | MalishevaMalisheva |
| 05 Aug 21 | r05        | Tvååkers IFTvååkers IF | 0 - 0 | Varbergs BoIS FCVarbergs BoIS |
| 06 Aug 21 | r05        | SociedadSociedad | 3 - 1 | EibarEibar |
| 06 Aug 21 | r05        | AltayAltay | 1 - 3 | ÜmraniyesporÜmraniyespor |
| 06 Aug 21 | r05        | FC GroningenFC Groningen | 0 - 0 | VeneziaVenezia |
| 06 Aug 21 | r05        | Adana DemirsporAdana Demirsp | 1 - 1 | BesiktasBesiktas |
| 06 Aug 21 | r05        | GranadaGranada | 3 - 1 | MalagaMalaga |
| 06 Aug 21 | r05        | Bradford Park AvenueBradford Park | 0 - 3 | Scarborough AthleticScarborough A |
| 06 Aug 21 | r05        | Apollon LimassolApollon Limas | 1 - 1 | Doxa KatokopiasDoxa Katokopi |
| 06 Aug 21 | r05        | SantanderSantander | 0 - 0 | BurgosBurgos |
| 06 Aug 21 | r05        | ValladolidValladolid | 2 - 2 | SD AmorebietaSD Amorebieta |
| 06 Aug 21 | r05        | Las PalmasLas Palmas | 3 - 0 | TamaraceiteTamaraceite |
| 06 Aug 21 | r05        | LevanteLevante | 0 - 1 | AlavesAlaves |
| 06 Aug 21 | r05        | PanathinaikosPanathinaikos | 2 - 2 | NK LokomotivaNK Lokomotiva |
| 06 Aug 21 | r05        | CrotoneCrotone | 1 - 1 | ViboneseVibonese |
| 06 Aug 21 | r05        | AlavesAlaves | 4 - 3 | Al-Nasr SalalahAl-Nasr Salal |
| 06 Aug 21 | r05        | SpeziaSpezia | - | CremoneseCremonese |
| 06 Aug 21 | r05        | Lippstadt 08Lippstadt 08 | 0 - 0 | KSV BaunatalKSV Baunatal |
| 06 Aug 21 | r05        | SPAL 2013SPAL 2013 | - | VeronaVerona |
| 06 Aug 21 | r05        | L-'HospitaletL-'Hospitalet | 0 - 0 | AndorraAndorra |
| 06 Aug 21 | r05        | Mancha RealMancha Real | 0 - 0 | Velez MostarVelez Mostar |
| 06 Aug 21 | r05        | DoverDover | 4 - 1 | WatfordWatford |
| 06 Aug 21 | r05        | MersthamMerstham | 0 - 0 | Dulwich HamletDulwich Hamle |
| 07 Aug 21 | r05        | Waasland-BeverenWaasland-Beve | 2 - 2 | SC CambuurSC Cambuur |
| 07 Aug 21 | r05        | Brackley TownBrackley Town | 1 - 0 | Oxford CityOxford City |
| 07 Aug 21 | r05        | Ossett UnitedOssett United | 1 - 2 | MatlockMatlock |
| 07 Aug 21 | r05        | Spennymoor Town FCSpennymoor To | 2 - 2 | WrexhamWrexham |
| 07 Aug 21 | r05        | Welling UnitedWelling Unite | 1 - 2 | BromleyBromley |
| 07 Aug 21 | r05        | RKC WaalwijkRKC Waalwijk | 4 - 2 | Lommel SKLommel SK |
| 07 Aug 21 | r05        | FC TwenteFC Twente | 0 - 1 | LazioLazio |
| 07 Aug 21 | r05        | SesveteSesvete | 2 - 0 | Dinamo Zagreb IIDinamo Zagreb |
| 07 Aug 21 | r05        | FC MinskFC Minsk | 0 - 2 | Isloch Minsk RaionIsloch Minsk |
| 07 Aug 21 | r05        | NumanciaNumancia | 2 - 0 | Rayo MajadahondaRayo Majadaho |
| 07 Aug 21 | r05        | VV DOVOVV DOVO | 3 - 1 | IJsselmeervogelsIJsselmeervog |
| 07 Aug 21 | r05        | FC UtrechtFC Utrecht | 2 - 3 | Fortuna SittardFortuna Sitta |
| 07 Aug 21 | r05        | Rot Weiss AhlenRot Weiss Ahl | 3 - 0 | FC GießenFC Gießen |
| 07 Aug 21 | r05        | Fortuna KölnFortuna Köln | 1 - 3 | TSV Steinbach HaigerTSV Steinbach |
| 07 Aug 21 | r05        | Nantwich TownNantwich Town | 3 - 2 | Chester CityChester City |
| 07 Aug 21 | r05        | Rot-Weiss EssenRot-Weiss Ess | 4 - 4 | SC VerlSC Verl |
| 07 Aug 21 | r05        | Stuttgart IIStuttgart II | 3 - 1 | TSG BalingenTSG Balingen |
| 07 Aug 21 | r05        | BurnleyBurnley | 0 - 2 | CadizCadiz |
| 07 Aug 21 | r05        | Dungannon SwiftsDungannon Swi | 3 - 1 | Moyola ParkMoyola Park |
| 07 Aug 21 | r05        | CirencesterCirencester | 3 - 2 | Didcot TownDidcot Town |
| 07 Aug 21 | r05        | Hungerford TownHungerford To | 1 - 1 | Gosport BoroughGosport Borou |
| 07 Aug 21 | r05        | MossleyMossley | 0 - 3 | StalybridgeStalybridge |
| 07 Aug 21 | r05        | SouthamptonSouthampton | 1 - 3 | Ath BilbaoAth Bilbao |
| 07 Aug 21 | r05        | Swindon SupermarineSwindon Super | 0 - 0 | BanburyBanbury |
| 07 Aug 21 | r05        | Tobermore UnitedTobermore Uni | 1 - 4 | Ballymena UnitedBallymena Uni |
| 07 Aug 21 | r05        | West HamWest Ham | 2 - 0 | AtalantaAtalanta |
| 07 Aug 21 | r05        | PAEEKPAEEK | 1 - 1 | Olympiakos NicosiaOlympiakos Ni |
| 07 Aug 21 | r05        | GiresunsporGiresunspor | 0 - 0 | SamsunsporSamsunspor |
| 07 Aug 21 | r05        | SassuoloSassuolo | 3 - 1 | L.R. Vicenza VirtusL.R. Vicenza |
| 07 Aug 21 | r05        | UdineseUdinese | 1 - 0 | EmpoliEmpoli |
| 07 Aug 21 | r05        | BrentfordBrentford | 2 - 1 | ValenciaValencia |
| 07 Aug 21 | r05        | FrosinoneFrosinone | 2 - 2 | BeneventoBenevento |
| 07 Aug 21 | r05        | SampdoriaSampdoria | 1 - 0 | VeronaVerona |
| 07 Aug 21 | r05        | BrightonBrighton | 0 - 2 | GetafeGetafe |
| 07 Aug 21 | r05        | GoztepeGoztepe | 2 - 0 | AltınorduAltınordu |
| 07 Aug 21 | r05        | ElcheElche | 1 - 2 | LevanteLevante |
| 07 Aug 21 | r05        | Gimnástica Segoviana CFGimnástica Se | 4 - 1 | Zamora F.C.Zamora F.C. |
| 07 Aug 21 | r05        | AachenAachen | 0 - 1 | FSV FrankfurtFSV Frankfurt |
| 07 Aug 21 | r05        | Atlas DelmenhorstAtlas Delmenh | 0 - 0 | Altona 93Altona 93 |
| 07 Aug 21 | r05        | Folkestone InvictaFolkestone In | 3 - 1 | MaidstoneMaidstone |
| 07 Aug 21 | r05        | HerefordHereford | 1 - 2 | Bath CityBath City |
| 07 Aug 21 | r05        | Stafford RangersStafford Rang | 1 - 1 | St Ives TownSt Ives Town |
| 07 Aug 21 | r05        | TamworthTamworth | 1 - 3 | ChesterfieldChesterfield |
| 07 Aug 21 | r05        | Warrington TownWarrington To | 2 - 1 | ChorleyChorley |
| 07 Aug 21 | r05        | WatfordWatford | - | UdineseUdinese |
| 07 Aug 21 | r05        | Bamber BridgeBamber Bridge | - | City of LiverpoolCity of Liver |
| 07 Aug 21 | r05        | Crusaders Crusaders | - | Banbridge TownBanbridge Tow |
| 07 Aug 21 | r05        | LewesLewes | 2 - 1 | DartfordDartford |
| 07 Aug 21 | r05        | Potters Bar TownPotters Bar T | 0 - 1 | Beaconsfield TownBeaconsfield |
| 07 Aug 21 | r05        | Wingate & FinchleyWingate & Fin | 2 - 3 | Harrow BoroughHarrow Boroug |
| 07 Aug 21 | r05        | BresciaBrescia | - | Reggio AudaceReggio Audace |
| 07 Aug 21 | r05        | SC HeerenveenSC Heerenveen | - | LecceLecce |
| 07 Aug 21 | r05        | GranadaGranada | 2 - 1 | Linares DeportivoLinares Depor |
| 07 Aug 21 | r05        | SabadellSabadell | 0 - 1 | Villarreal BVillarreal B |
| 07 Aug 21 | r05        | AnkaragucuAnkaragucu | 0 - 0 | GenclerbirligiGenclerbirlig |
| 07 Aug 21 | r05        | VillarrealVillarreal | - | LeedsLeeds |
| 07 Aug 21 | r05        | PisaPisa | - | ModenaModena |
| 08 Aug 21 | r05        | LamiaLamia | 3 - 0 | IonikosIonikos |
| 08 Aug 21 | r05        | AZ AlkmaarAZ Alkmaar | 2 - 1 | TorinoTorino |
| 08 Aug 21 | r05        | PanetolikosPanetolikos | 0 - 0 | GianninaGiannina |
| 08 Aug 21 | r05        | FeyenoordFeyenoord | 2 - 1 | Ath MadridAth Madrid |
| 08 Aug 21 | r05        | LiverpoolLiverpool | 1 - 1 | Ath BilbaoAth Bilbao |
| 08 Aug 21 | r05        | Parma Calcio 1913Parma Calcio | 0 - 2 | InterInter |
| 08 Aug 21 | r05        | BolognaBologna | 4 - 2 | Pordenone CalcioPordenone Cal |
| 08 Aug 21 | r05        | BarcelonaBarcelona | 3 - 0 | JuventusJuventus |
| 09 Aug 21 | r05        | LiverpoolLiverpool | 3 - 1 | OsasunaOsasuna |
| 10 Aug 21 | r05        | TamworthTamworth | - | Notts CountyNotts County |
| 10 Aug 21 | r05        | Carrick RangersCarrick Range | - | PSNIPSNI |
| 15 Aug 21 | r05        | La CorunaLa Coruna | 0 - 0 | Real Madrid BReal Madrid B |
| 15 Aug 21 | r05        | CD Móstoles URJCCD Móstoles U | 0 - 0 | Mar MenorMar Menor |
| 15 Aug 21 | r05        | AndorraAndorra | 2 - 0 | Atlètic d'EscaldesAtlètic d'Esc |
| 15 Aug 21 | r05        | WeymouthWeymouth | 0 - 13 | ChelseaChelsea |
| 15 Aug 21 | r05        | US MonastirUS Monastir | 4 - 1 | Hammam-SousseHammam-Sousse |
| 16 Aug 21 | r05        | LeganesLeganes | 3 - 0 | SS ReyesSS Reyes |
| 17 Aug 21 | r05        | KF Vllaznia ShkodërKF Vllaznia S | 1 - 0 | Tërbuni PukëTërbuni Pukë |
| 17 Aug 21 | r05        | Sevilla AtleticoSevilla Atlet | 4 - 0 | AD Ceuta FCAD Ceuta FC |
| 17 Aug 21 | r05        | VillarrobledoVillarrobledo | 1 - 0 | SocuéllamosSocuéllamos |
| 18 Aug 21 | r05        | LeonesaLeonesa | 1 - 1 | UD LlaneraUD Llanera |
| 18 Aug 21 | r05        | Gimnástica Segoviana CFGimnástica Se | 1 - 1 | Las Rozas CFLas Rozas CF |
| 18 Aug 21 | r05        | Espanyol BEspanyol B | 2 - 3 | CornellàCornellà |
| 18 Aug 21 | r05        | ForliForli | 2 - 2 | CesenaCesena |
| 18 Aug 21 | r05        | Achyronas LiopetriouAchyronas Lio | 2 - 4 | Alki OrokliniAlki Oroklini |
| 18 Aug 21 | r05        | Real Madrid BReal Madrid B | 1 - 1 | BadajozBadajoz |
| 18 Aug 21 | r05        | UCAM MurciaUCAM Murcia | 1 - 0 | El EjidoEl Ejido |
| 18 Aug 21 | r05        | CD VareaCD Varea | 0 - 5 | Alavés BAlavés B |
| 19 Aug 21 | r05        | SocuéllamosSocuéllamos | 1 - 1 | VillarrubiaVillarrubia |
| 19 Aug 21 | r05        | CordobaCordoba | 1 - 0 | ExtremaduraExtremadura |
| 19 Aug 21 | r05        | Real CalepinaReal Calepina | 0 - 1 | OlginateseOlginatese |
| 19 Aug 21 | r05        | Qadsia SCQadsia SC | 1 - 1 | Al-MarkhiyaAl-Markhiya |
| 20 Aug 21 | r05        | AEL LimassolAEL Limassol | 0 - 0 | PAEEKPAEEK |
| 20 Aug 21 | r05        | ASILASIL | 0 - 0 | Nea Salamis FamagustaNea Salamis F |
| 20 Aug 21 | r05        | Real UniónReal Unión | 0 - 1 | CD IzarraCD Izarra |
| 20 Aug 21 | r05        | Burgos PromesasBurgos Promes | 3 - 1 | Zamora F.C.Zamora F.C. |
| 20 Aug 21 | r05        | AlziraAlzira | 1 - 0 | CastellónCastellón |
| 20 Aug 21 | r05        | El EjidoEl Ejido | 2 - 1 | Recreativo GranadaRecreativo Gr |
| 21 Aug 21 | r05        | Alki OrokliniAlki Oroklini | 5 - 1 | ASILASIL |
| 21 Aug 21 | r05        | BelasicaBelasica | 1 - 2 | VardarVardar |
| 21 Aug 21 | r05        | PanathinaikosPanathinaikos | 1 - 2 | PanetolikosPanetolikos |
| 21 Aug 21 | r05        | CalahorraCalahorra | 2 - 0 | EbroEbro |
| 21 Aug 21 | r05        | La CorunaLa Coruna | 3 - 2 | PontevedraPontevedra |
| 21 Aug 21 | r05        | UD LlaneraUD Llanera | 3 - 0 | Real Oviedo BReal Oviedo B |
| 21 Aug 21 | r05        | SantanderSantander | 2 - 2 | NumanciaNumancia |
| 21 Aug 21 | r05        | Real Madrid BReal Madrid B | 1 - 0 | Athletic Bilbao BAthletic Bilb |
| 21 Aug 21 | r05        | U.S. Folgore Caratese A.SU.S. Folgore | 1 - 2 | USD CasateseUSD Casatese |
| 21 Aug 21 | r05        | Akritas ChlorakasAkritas Chlor | 0 - 4 | Nea Salamis FamagustaNea Salamis F |
| 21 Aug 21 | r05        | Apollon SmirnisApollon Smirn | 1 - 2 | OFIOFI |
| 21 Aug 21 | r05        | AtromitosAtromitos | 1 - 1 | LamiaLamia |
| 21 Aug 21 | r05        | OlotOlot | 0 - 1 | GimnasticGimnastic |
| 21 Aug 21 | r05        | SabadellSabadell | 1 - 0 | AndorraAndorra |
| 21 Aug 21 | r05        | AEKAEK | 0 - 1 | Asteras TripolisAsteras Tripo |
| 21 Aug 21 | r05        | Aris LimassolAris Limassol | 4 - 1 | GianninaGiannina |
| 21 Aug 21 | r05        | Xerez DeportivoXerez Deporti | 2 - 1 | UD San FernandoUD San Fernan |
| 22 Aug 21 | r05        | AE PratAE Prat | 1 - 0 | CornellàCornellà |
| 22 Aug 21 | r05        | CacereñoCacereño | 0 - 3 | Mérida ADMérida AD |
| 22 Aug 21 | r05        | VillanovenseVillanovense | 0 - 0 | BadajozBadajoz |
| 22 Aug 21 | r05        | SK TiranaSK Tirana | 1 - 0 | KF Vllaznia ShkodërKF Vllaznia S |
| 22 Aug 21 | r05        | Cerdanyola del VallèsCerdanyola de | 0 - 2 | Espanyol BEspanyol B |
| 22 Aug 21 | r05        | TalaveraTalavera | 1 - 0 | Unionistas de SalamancaUnionistas de |
| 23 Aug 21 | r05        | SakaryasporSakaryaspor | 1 - 1 | KırklarelisporKırklarelispo |
| 25 Aug 21 | r05        | Ayia NapaAyia Napa | 1 - 0 | Omonia AradippouOmonia Aradip |
| 25 Aug 21 | r05        | Nea Salamis FamagustaNea Salamis F | 1 - 1 | Doxa KatokopiasDoxa Katokopi |
| 25 Aug 21 | r05        | VoždovacVoždovac | 0 - 2 | OmanOman |
| 25 Aug 21 | r05        | VillarrobledoVillarrobledo | 2 - 1 | Mérida ADMérida AD |
| 26 Aug 21 | r05        | Pafos FCPafos FC | 0 - 0 | KarmiotissaKarmiotissa |
| 27 Aug 21 | r05        | AEL LimassolAEL Limassol | 2 - 1 | OthellosOthellos |
| 27 Aug 21 | r05        | OnisilosOnisilos | 0 - 0 | Enosis Neon ParalimniEnosis Neon P |
| 27 Aug 21 | r05        | AEK LarnacaAEK Larnaca | 2 - 1 | Aris LimassolAris Limassol |
| 28 Aug 21 | r05        | OurenseOurense | 2 - 2 | CoruxoCoruxo |
| 28 Aug 21 | r05        | Osasuna BOsasuna B | 0 - 2 | EbroEbro |
| 28 Aug 21 | r05        | BarakaldoBarakaldo | 0 - 0 | Arenas ClubArenas Club |
| 28 Aug 21 | r05        | Salamanca UDSSalamanca UDS | 0 - 1 | GuijueloGuijuelo |
| 08 Sep 21 | r05        | WesterloWesterlo | 0 - 5 | St.TruidenSt.Truiden |
| 11 Sep 21 | r05        | KitcheeKitchee | 2 - 1 | Lee ManLee Man |
| 11 Sep 21 | r05        | ErgotelisErgotelis | 1 - 1 | ChaniaChania |
| 22 Sep 21 | r05        | TuskerTusker | 2 - 1 | GOR MahiaGOR Mahia |
| 22 Sep 21 | r05        | RejicheRejiche | 2 - 0 | CS Hammam-LifCS Hammam-Lif |
| 23 Sep 21 | r05        | CS ChebbaCS Chebba | 2 - 2 | Étoile Sportive du SahelÉtoile Sporti |
| 05 Oct 21 | r05        | DobrudzhaDobrudzha | 0 - 2 | Cherno MoreCherno More |
| 06 Oct 21 | r05        | WolfsburgWolfsburg | 4 - 1 | HamburgHamburg |
| 06 Oct 21 | r05        | RasenBallsport LeipzigRasenBallspor | 1 - 2 | Slask WroclawSlask Wroclaw |
| 06 Oct 21 | r05        | Union BerlinUnion Berlin | 1 - 3 | St. GallenSt. Gallen |
| 06 Oct 21 | r05        | TSV HartbergTSV Hartberg | 1 - 0 | SV KapfenbergSV Kapfenberg |
| 07 Oct 21 | r05        | FreiburgFreiburg | 3 - 0 | St PauliSt Pauli |
| 07 Oct 21 | r05        | CD GuadalajaraCD Guadalajar | 0 - 0 | FASFAS |
| 07 Oct 21 | r05        | Go Ahead EaglesGo Ahead Eagl | 2 - 2 | Lommel SKLommel SK |
| 07 Oct 21 | r05        | BochumBochum | 5 - 4 | NEC NijmegenNEC Nijmegen |
| 07 Oct 21 | r05        | Holstein KielHolstein Kiel | 0 - 0 | Silkeborg IFSilkeborg IF |
| 07 Oct 21 | r05        | Dynamo DresdenDynamo Dresde | 4 - 0 | Viktoria BerlinViktoria Berl |
| 07 Oct 21 | r05        | FC UtrechtFC Utrecht | 3 - 2 | SpartaSparta |
| 07 Oct 21 | r05        | DornbirnDornbirn | 0 - 3 | VaduzVaduz |
| 07 Oct 21 | r05        | FC LieferingFC Liefering | 1 - 1 | SKU AmstettenSKU Amstetten |
| 07 Oct 21 | r05        | StuttgartStuttgart | 1 - 4 | SandhausenSandhausen |
| 07 Oct 21 | r05        | AugsburgAugsburg | 1 - 0 | Jahn RegensburgJahn Regensbu |
| 07 Oct 21 | r05        | SKN St. PoltenSKN St. Polte | - | Floridsdorfer ACFloridsdorfer |
| 07 Oct 21 | r05        | Schalke 04Schalke 04 | 2 - 0 | LübeckLübeck |
| 07 Oct 21 | r05        | HostertHostert | 2 - 3 | Swift HesperangeSwift Hespera |
| 08 Oct 21 | r05        | SV Josko RiedSV Josko Ried | 2 - 1 | SK Vorwarts SteyrSK Vorwarts S |
| 08 Oct 21 | r05        | Dukla PrahaDukla Praha | 4 - 3 | BohemiansBohemians |
| 09 Oct 21 | r05        | BorecBorec | 2 - 0 | VardarVardar |
| 11 Nov 21 | r05        | BesiktasBesiktas | 3 - 0 | ShkupiShkupi |
| 10 Dec 21 | r05        | FC LahtiFC Lahti | - | FC HakaFC Haka |
| 11 Dec 21 | r05        | KuPS KuopioKuPS Kuopio | 3 - 3 | AC OuluAC Oulu |
| 17 Dec 21 | r05        | FC HakaFC Haka | 1 - 4 | KuPS KuopioKuPS Kuopio |
| 17 Dec 21 | r05        | MPMP | 3 - 3 | IlvesIlves |
| 21 Dec 21 | r05        | VenadosVenados | 1 - 2 | Cruz AzulCruz Azul |
| 23 Dec 21 | r05        | Atletico de San LuisAtletico de S | 3 - 1 | NecaxaNecaxa |
| 29 Dec 21 | r05        | Energetik-BGU MinskEnergetik-BGU | 2 - 1 | Isloch Minsk RaionIsloch Minsk |
| 30 Dec 21 | r05        | NecaxaNecaxa | 2 - 3 | CD GuadalajaraCD Guadalajar |
| 04 Jan 22 | r05        | WolfsburgWolfsburg | 5 - 4 | PaderbornPaderborn |
| 05 Jan 22 | r05        | Waldhof MannheimWaldhof Mannh | - | Hansa RostockHansa Rostock |
| 05 Jan 22 | r05        | Holstein KielHolstein Kiel | 5 - 0 | TSV HavelseTSV Havelse |
| 05 Jan 22 | r05        | FC HeidenheimFC Heidenheim | 2 - 1 | Beerschot VABeerschot VA |
| 05 Jan 22 | r05        | Club BruggeClub Brugge | - | KarlsruheKarlsruhe |
| 05 Jan 22 | r05        | KarlsruheKarlsruhe | 0 - 0 | Club BruggeClub Brugge |
| 05 Jan 22 | r05        | Werder BremenWerder Bremen | - | St.TruidenSt.Truiden |
| 05 Jan 22 | r05        | FarnboroughFarnborough | 1 - 0 | BournemouthBournemouth |
| 06 Jan 22 | r05        | FC GroningenFC Groningen | 1 - 1 | SV MeppenSV Meppen |
| 06 Jan 22 | r05        | IngolstadtIngolstadt | 3 - 1 | Wuerzburger KickersWuerzburger K |
| 06 Jan 22 | r05        | RödinghausenRödinghausen | 0 - 5 | OsnabrueckOsnabrueck |
| 06 Jan 22 | r05        | AzamAzam | 1 - 0 | Namungo FCNamungo FC |
| 07 Jan 22 | r05        | Munich 1860Munich 1860 | 3 - 1 | Hansa RostockHansa Rostock |
| 07 Jan 22 | r05        | Carl Zeiss JenaCarl Zeiss Je | 2 - 3 | ZwickauZwickau |
| 07 Jan 22 | r05        | Fortuna KölnFortuna Köln | 2 - 2 | DuisburgDuisburg |
| 07 Jan 22 | r05        | Go Ahead EaglesGo Ahead Eagl | 1 - 2 | Dortmund IIDortmund II |
| 07 Jan 22 | r05        | HamburgHamburg | - | NEC NijmegenNEC Nijmegen |
| 07 Jan 22 | r05        | Young AfricansYoung African | 2 - 2 | KMKM FCKMKM FC |
| 07 Jan 22 | r05        | Wehen WiesbadenWehen Wiesbad | 4 - 1 | MechelenMechelen |
| 07 Jan 22 | r05        | Willem IIWillem II | - | SC CambuurSC Cambuur |
| 07 Jan 22 | r05        | GentGent | 0 - 1 | AZ AlkmaarAZ Alkmaar |
| 07 Jan 22 | r05        | Simba SCSimba SC | 0 - 0 | MlandegeMlandege |
| 08 Jan 22 | r05        | EskisehirsporEskisehirspor | 0 - 2 | Türkgücü MünchenTürkgücü Münc |
| 08 Jan 22 | r05        | Arges PitestiArges Pitesti | - | CS MioveniCS Mioveni |
| 08 Jan 22 | r05        | LiberecLiberec | 0 - 1 | ChrudimChrudim |
| 08 Jan 22 | r05        | SiófokSiófok | 2 - 4 | SoroksárSoroksár |
| 08 Jan 22 | r05        | Zalaegerszegi TEZalaegerszegi | 2 - 4 | III Kerületi TVEIII Kerületi |
| 08 Jan 22 | r05        | ZlínZlín | 2 - 2 | LíšeňLíšeň |
| 08 Jan 22 | r05        | Bonner SCBonner SC | 1 - 1 | Rot-Weiß KoblenzRot-Weiß Kobl |
| 08 Jan 22 | r05        | OsijekOsijek | 2 - 0 | BSK Bijelo BrdoBSK Bijelo Br |
| 08 Jan 22 | r05        | ViborgViborg | 2 - 0 | HOBROHOBRO |
| 08 Jan 22 | r05        | FeyenoordFeyenoord | P - P | Club BruggeClub Brugge |
| 08 Jan 22 | r05        | HannoverHannover | 2 - 2 | Werder BremenWerder Bremen |
| 08 Jan 22 | r05        | Hansa RostockHansa Rostock | - | SamsunsporSamsunspor |
| 08 Jan 22 | r05        | Mezőkövesdi SEMezőkövesdi S | 4 - 0 | Szentlőrinc SESzentlőrinc S |
| 08 Jan 22 | r05        | Fortuna DüsseldorfFortuna Düsse | 2 - 1 | Freiburg IIFreiburg II |
| 08 Jan 22 | r05        | GyirmótGyirmót | 0 - 2 | DorogDorog |
| 08 Jan 22 | r05        | Holstein KielHolstein Kiel | 3 - 2 | OsnabrueckOsnabrueck |
| 08 Jan 22 | r05        | NK LokomotivaNK Lokomotiva | 4 - 3 | NK AluminijNK Aluminij |
| 08 Jan 22 | r05        | Schalke 04Schalke 04 | 1 - 1 | Fortuna SittardFortuna Sitta |
| 08 Jan 22 | r05        | Young BoysYoung Boys | 6 - 1 | ThunThun |
| 08 Jan 22 | r05        | MönchengladbachMönchengladba | 2 - 3 | Viktoria KölnViktoria Köln |
| 08 Jan 22 | r05        | DarmstadtDarmstadt | 4 - 2 | Jahn RegensburgJahn Regensbu |
| 08 Jan 22 | r05        | NurnbergNurnberg | 5 - 1 | Hallescher FCHallescher FC |
| 08 Jan 22 | r05        | Drochtersen-AsselDrochtersen-A | - | Heider SVHeider SV |
| 08 Jan 22 | r05        | EupenEupen | 1 - 2 | KaiserslauternKaiserslauter |
| 08 Jan 22 | r05        | Rot-Weiß OberhausenRot-Weiß Ober | 6 - 1 | KFC Uerdingen 05KFC Uerdingen |
| 08 Jan 22 | r05        | Preußen MünsterPreußen Münst | - | DuisburgDuisburg |
| 08 Jan 22 | r05        | Dynamo DresdenDynamo Dresde | 5 - 0 | AueAue |
| 08 Jan 22 | r05        | StraelenStraelen | - | SC Heracles AlmeloSC Heracles A |
| 08 Jan 22 | r05        | SC VerlSC Verl | 0 - 2 | PaderbornPaderborn |
| 08 Jan 22 | r05        | Werder BremenWerder Bremen | - | Cercle BruggeCercle Brugge |
| 08 Jan 22 | r05        | FC BaselFC Basel | 3 - 1 | SandhausenSandhausen |
| 08 Jan 22 | r05        | SC KriensSC Kriens | 2 - 1 | LucerneLucerne |
| 08 Jan 22 | r05        | FC Koln IIFC Koln II | - | DiosgyorDiosgyor |
| 08 Jan 22 | r05        | Oud-Heverlee LeuvenOud-Heverlee | 1 - 3 | FC HeidenheimFC Heidenheim |
| 08 Jan 22 | r05        | Puskás Akadémia FCPuskás Akadém | - | KMSK DeinzeKMSK Deinze |
| 08 Jan 22 | r05        | Rot-Weiss EssenRot-Weiss Ess | 1 - 2 | SV MeppenSV Meppen |
| 09 Jan 22 | r05        | Uta AradUta Arad | 1 - 4 | CharleroiCharleroi |
| 09 Jan 22 | r05        | AnderlechtAnderlecht | 2 - 0 | WesterloWesterlo |
| 09 Jan 22 | r05        | Wuerzburger KickersWuerzburger K | 4 - 0 | AalenAalen |
| 09 Jan 22 | r05        | PaderbornPaderborn | - | SC Heracles AlmeloSC Heracles A |
| 09 Jan 22 | r05        | AjaxAjax | - | Hajduk SplitHajduk Split |
| 09 Jan 22 | r05        | Paksi FCPaksi FC | 2 - 5 | Universitatea CraiovaUniversitatea |
| 09 Jan 22 | r05        | KarlsruheKarlsruhe | 2 - 1 | DiosgyorDiosgyor |
| 10 Jan 22 | r05        | RödinghausenRödinghausen | 1 - 4 | FC GroningenFC Groningen |
| 10 Jan 22 | r05        | Türkgücü MünchenTürkgücü Münc | - | FC BotoșaniFC Botoșani |
| 11 Jan 22 | r05        | Rapid BucurestiRapid Bucures | 1 - 3 | SamsunsporSamsunspor |
| 11 Jan 22 | r05        | Dortmund IIDortmund II | 4 - 0 | AachenAachen |
| 11 Jan 22 | r05        | Gaz Metan MediașGaz Metan Med | 2 - 1 | VaduzVaduz |
| 11 Jan 22 | r05        | GrasshoppersGrasshoppers | 2 - 2 | FC WilFC Wil |
| 11 Jan 22 | r05        | Dinamo ZagrebDinamo Zagreb | 2 - 0 | Olimpija LjubljanaOlimpija Ljub |
| 11 Jan 22 | r05        | Fortuna Düsseldorf IIFortuna Düsse | - | TSV Steinbach HaigerTSV Steinbach |
| 11 Jan 22 | r05        | DiosgyorDiosgyor | 0 - 2 | KMSK DeinzeKMSK Deinze |
| 11 Jan 22 | r05        | LinfieldLinfield | 0 - 1 | LarneLarne |
| 12 Jan 22 | r05        | Dinamo BucurestiDinamo Bucure | P - P | CS MioveniCS Mioveni |
| 12 Jan 22 | r05        | Viktoria PlzenViktoria Plze | 6 - 0 | PribramPribram |
| 12 Jan 22 | r05        | Dynamo České BudějoviceDynamo České | 1 - 0 | TáborskoTáborsko |
| 12 Jan 22 | r05        | LiberecLiberec | - | VarnsdorfVarnsdorf |
| 12 Jan 22 | r05        | Sparta PragueSparta Prague | 5 - 0 | ChrudimChrudim |
| 12 Jan 22 | r05        | NK Istra 1961NK Istra 1961 | 0 - 2 | ŽarkovoŽarkovo |
| 12 Jan 22 | r05        | CS MioveniCS Mioveni | 2 - 0 | Dinamo BatumiDinamo Batumi |
| 12 Jan 22 | r05        | Wisla KrakowWisla Krakow | 3 - 0 | Tatran Liptovský MikulášTatran Liptov |
| 12 Jan 22 | r05        | Paksi FCPaksi FC | 3 - 0 | Chindia TârgovișteChindia Târgo |
| 12 Jan 22 | r05        | NK BravoNK Bravo | 1 - 1 | Budafoki MTEBudafoki MTE |
| 12 Jan 22 | r05        | LuganoLugano | 1 - 2 | FC BaselFC Basel |
| 12 Jan 22 | r05        | Uta AradUta Arad | - | Kispest HonvedKispest Honve |
| 12 Jan 22 | r05        | DebrecenDebrecen | 4 - 0 | KazincbarcikaKazincbarcika |
| 12 Jan 22 | r05        | GyirmótGyirmót | - | III Kerületi TVEIII Kerületi |
| 12 Jan 22 | r05        | SoroksárSoroksár | - | Zalaegerszegi TEZalaegerszegi |
| 12 Jan 22 | r05        | Zalaegerszegi TEZalaegerszegi | 1 - 0 | Videoton FC FehervarVideoton FC F |
| 12 Jan 22 | r05        | RijekaRijeka | 2 - 3 | DomzaleDomzale |
| 12 Jan 22 | r05        | Universitatea CraiovaUniversitatea | - | RaufossRaufoss |
| 12 Jan 22 | r05        | Young BoysYoung Boys | 4 - 2 | ServetteServette |
| 12 Jan 22 | r05        | SV KapfenbergSV Kapfenberg | - | NŠ MuraNŠ Mura |
| 12 Jan 22 | r05        | Tennis Borussia BerlinTennis Boruss | - | Viktoria BerlinViktoria Berl |
| 12 Jan 22 | r05        | AimoréAimoré | 0 - 0 | CaxiasCaxias |
| 13 Jan 22 | r05        | Slavia SofiaSlavia Sofia | 3 - 1 | Hebar PazardzhikHebar Pazardz |
| 13 Jan 22 | r05        | ZurichZurich | 3 - 3 | Wuppertaler SVWuppertaler S |
| 13 Jan 22 | r05        | Hajduk SplitHajduk Split | - | ServetteServette |
| 13 Jan 22 | r05        | DugopoljeDugopolje | 3 - 0 | OpatijaOpatija |
| 13 Jan 22 | r05        | Rapid ViennaRapid Vienna | 4 - 0 | SV LafnitzSV Lafnitz |
| 13 Jan 22 | r05        | FC AarauFC Aarau | 4 - 1 | FC VoluntariFC Voluntari |
| 13 Jan 22 | r05        | St. GallenSt. Gallen | 5 - 5 | FC WinterthurFC Winterthur |
| 13 Jan 22 | r05        | Lechia GdańskLechia Gdańsk | 3 - 2 | FC BotoșaniFC Botoșani |
| 13 Jan 22 | r05        | CFR Cluj-NapocaCFR Cluj-Napo | 1 - 0 | La NucíaLa Nucía |
| 13 Jan 22 | r05        | UD IbizaUD Ibiza | 1 - 1 | Peña DeportivaPeña Deportiv |
| 14 Jan 22 | r05        | MTK HungariaMTK Hungaria | - | CsákvárCsákvár |
| 14 Jan 22 | r05        | MalagaMalaga | - | Puskás Akadémia FCPuskás Akadém |
| 14 Jan 22 | r05        | Real UniónReal Unión | 0 - 1 | EibarEibar |
| 14 Jan 22 | r05        | HOBROHOBRO | 0 - 3 | Randers FCRanders FC |
| 14 Jan 22 | r05        | Slask WroclawSlask Wroclaw | 1 - 0 | Warta PoznańWarta Poznań |
| 14 Jan 22 | r05        | LiberecLiberec | 2 - 0 | Chindia TârgovișteChindia Târgo |
| 14 Jan 22 | r05        | FC U Craiova 1948FC U Craiova | 3 - 0 | 1599 Șelimbăr1599 Șelimbăr |
| 14 Jan 22 | r05        | Rakow CzestochowaRakow Czestoc | 1 - 2 | Rapid BucurestiRapid Bucures |
| 14 Jan 22 | r05        | Austria LustenauAustria Luste | 1 - 1 | WSG Swarovski TirolWSG Swarovski |
| 14 Jan 22 | r05        | HNK GoricaHNK Gorica | 4 - 0 | RadomljeRadomlje |
| 14 Jan 22 | r05        | Neftçi PFKNeftçi PFK | 2 - 2 | Kisvárda FCKisvárda FC |
| 14 Jan 22 | r05        | FC AarauFC Aarau | 2 - 1 | Uta AradUta Arad |
| 14 Jan 22 | r05        | Banik OstravaBanik Ostrava | - | FC U Craiova 1948FC U Craiova |
| 14 Jan 22 | r05        | SV SalzburgSV Salzburg | 6 - 0 | SKU AmstettenSKU Amstetten |
| 14 Jan 22 | r05        | Szombathelyi HaladásSzombathelyi | - | TSV HartbergTSV Hartberg |
| 14 Jan 22 | r05        | DiosgyorDiosgyor | - | Waasland-BeverenWaasland-Beve |
| 14 Jan 22 | r05        | Europa PointEuropa Point | 0 - 8 | DiosgyorDiosgyor |
| 14 Jan 22 | r05        | Slavia PragueSlavia Prague | - | ServetteServette |
| 14 Jan 22 | r05        | KhalidiyaKhalidiya | 1 - 3 | CordobaCordoba |
| 14 Jan 22 | r05        | ViborgViborg | 5 - 0 | JammerbugtJammerbugt |
| 14 Jan 22 | r05        | B.93B.93 | 0 - 1 | Hvidovre IFHvidovre IF |
| 14 Jan 22 | r05        | Wiener NeustadtWiener Neusta | 5 - 0 | Austria Vienna (Am)Austria Vienn |
| 14 Jan 22 | r05        | FremFrem | 0 - 5 | AB GladsaxeAB Gladsaxe |
| 14 Jan 22 | r05        | FigueirenseFigueirense | 0 - 0 | BrusqueBrusque |
| 15 Jan 22 | r05        | Alianza LimaAlianza Lima | 3 - 2 | La EquidadLa Equidad |
| 15 Jan 22 | r05        | Energetik-BGU MinskEnergetik-BGU | 1 - 0 | FC MinskFC Minsk |
| 15 Jan 22 | r05        | AC HorsensAC Horsens | 5 - 0 | Aarhus FremadAarhus Fremad |
| 15 Jan 22 | r05        | Viktoria PlzenViktoria Plze | 1 - 0 | Ústí nad LabemÚstí nad Labe |
| 15 Jan 22 | r05        | Zbrojovka BrnoZbrojovka Brn | 3 - 3 | ZlínZlín |
| 15 Jan 22 | r05        | Dynamo České BudějoviceDynamo České | 2 - 0 | PribramPribram |
| 15 Jan 22 | r05        | Hradec KrálovéHradec Králov | - | LiberecLiberec |
| 15 Jan 22 | r05        | Schalke 04 IISchalke 04 II | - | Stuttgart IIStuttgart II |
| 15 Jan 22 | r05        | Slavoj VyšehradSlavoj Vyšehr | - | ChrudimChrudim |
| 15 Jan 22 | r05        | DomzaleDomzale | 2 - 2 | Budafoki MTEBudafoki MTE |
| 15 Jan 22 | r05        | EldenseEldense | 2 - 2 | UCAM MurciaUCAM Murcia |
| 15 Jan 22 | r05        | Kolding IFKolding IF | 0 - 2 | SønderjyskeSønderjyske |
| 15 Jan 22 | r05        | FC Lausanne-SportFC Lausanne-S | 1 - 1 | Stade Lausanne OuchyStade Lausann |
| 15 Jan 22 | r05        | CS MioveniCS Mioveni | 0 - 0 | Steaua BucurestiSteaua Bucure |
| 15 Jan 22 | r05        | Racing FC Union LuxembourRacing FC Uni | 1 - 3 | ElversbergElversberg |
| 15 Jan 22 | r05        | Shakhter SoligorskShakhter Soli | 3 - 0 | Slavia MozyrSlavia Mozyr |
| 15 Jan 22 | r05        | FC Koln IIFC Koln II | 1 - 1 | Rot-Weiß KoblenzRot-Weiß Kobl |
| 15 Jan 22 | r05        | Dynamo DresdenDynamo Dresde | 0 - 3 | Carl Zeiss JenaCarl Zeiss Je |
| 15 Jan 22 | r05        | Miedz LegnicaMiedz Legnica | 0 - 2 | Górnik PolkowiceGórnik Polkow |
| 15 Jan 22 | r05        | CD ToledoCD Toledo | 2 - 0 | CD Móstoles URJCCD Móstoles U |
| 15 Jan 22 | r05        | Augsburg IIAugsburg II | 1 - 3 | AalenAalen |
| 15 Jan 22 | r05        | KarvinaKarvina | 1 - 3 | Tatran Liptovský MikulášTatran Liptov |
| 15 Jan 22 | r05        | Legia WarsawLegia Warsaw | 2 - 0 | Botev PlovdivBotev Plovdiv |
| 15 Jan 22 | r05        | Zaglebie SosnowiecZaglebie Sosn | 2 - 2 | Resovia RzeszówResovia Rzesz |
| 15 Jan 22 | r05        | Warta PoznańWarta Poznań | 1 - 0 | Arka GdyniaArka Gdynia |
| 15 Jan 22 | r05        | GyorGyor | 5 - 2 | SzolnokSzolnok |
| 15 Jan 22 | r05        | Kispest HonvedKispest Honve | 0 - 0 | Zalaegerszegi TEZalaegerszegi |
| 15 Jan 22 | r05        | Liverpool MontevideoLiverpool Mon | 1 - 1 | RentistasRentistas |
| 15 Jan 22 | r05        | SiófokSiófok | 2 - 2 | Shkendija 79Shkendija 79 |
| 15 Jan 22 | r05        | WanderersWanderers | 0 - 1 | Boston RiverBoston River |
| 15 Jan 22 | r05        | Young BoysYoung Boys | 5 - 2 | GrasshoppersGrasshoppers |
| 15 Jan 22 | r05        | CottbusCottbus | - | Hertha ZehlendorfHertha Zehlen |
| 15 Jan 22 | r05        | Nomme KaljuNomme Kalju | 2 - 2 | Tallinna JK LegionTallinna JK L |
| 15 Jan 22 | r05        | LASKLASK | 7 - 1 | Grazer AKGrazer AK |
| 15 Jan 22 | r05        | AachenAachen | 2 - 4 | WesterloWesterlo |
| 15 Jan 22 | r05        | CFR Cluj-NapocaCFR Cluj-Napo | - | FerencvarosFerencvaros |
| 15 Jan 22 | r05        | GyirmótGyirmót | - | VasasVasas |
| 15 Jan 22 | r05        | KPVKPV | - | SJK SeinajokiSJK Seinajoki |
| 15 Jan 22 | r05        | Mezőkövesdi SEMezőkövesdi S | - | Jagiellonia BialystokJagiellonia B |
| 15 Jan 22 | r05        | FK PirmasensFK Pirmasens | 0 - 4 | Etzella EttelbruckEtzella Ettel |
| 15 Jan 22 | r05        | SV Josko RiedSV Josko Ried | 1 - 1 | SK Vorwarts SteyrSK Vorwarts S |
| 15 Jan 22 | r05        | WiedenbrückWiedenbrück | 1 - 3 | Rot-Weiß OberhausenRot-Weiß Ober |
| 15 Jan 22 | r05        | Neuchâtel XamaxNeuchâtel Xam | 1 - 3 | ThunThun |
| 15 Jan 22 | r05        | Zalaegerszegi TEZalaegerszegi | - | NŠ MuraNŠ Mura |
| 15 Jan 22 | r05        | VfB HombergVfB Homberg | 4 - 2 | StraelenStraelen |
| 15 Jan 22 | r05        | LuganoLugano | 3 - 0 | VaduzVaduz |
| 15 Jan 22 | r05        | OsijekOsijek | 3 - 0 | Olimpija LjubljanaOlimpija Ljub |
| 15 Jan 22 | r05        | SJK SeinajokiSJK Seinajoki | 1 - 1 | FC HakaFC Haka |
| 15 Jan 22 | r05        | PK-35PK-35 | - | KTPKTP |
| 15 Jan 22 | r05        | Paksi FCPaksi FC | 1 - 1 | Sabah FCSabah FC |
| 15 Jan 22 | r05        | BellinzonaBellinzona | - | SchaffhausenSchaffhausen |
| 15 Jan 22 | r05        | LucerneLucerne | 0 - 1 | FC WinterthurFC Winterthur |
| 15 Jan 22 | r05        | Sturm GrazSturm Graz | 0 - 2 | Videoton FC FehervarVideoton FC F |
| 15 Jan 22 | r05        | Rot Weiss AhlenRot Weiss Ahl | 3 - 4 | FSV FrankfurtFSV Frankfurt |
| 15 Jan 22 | r05        | FC GießenFC Gießen | 1 - 2 | Mainz IIMainz II |
| 15 Jan 22 | r05        | Isloch Minsk RaionIsloch Minsk | 0 - 0 | FC Dnepr MogilevFC Dnepr Mogi |
| 15 Jan 22 | r05        | OHigginsOHiggins | 1 - 0 | Deportes Santa CruzDeportes Sant |
| 15 Jan 22 | r05        | RijekaRijeka | 3 - 0 | NK BravoNK Bravo |
| 15 Jan 22 | r05        | ŠibenikŠibenik | 0 - 3 | ŽarkovoŽarkovo |
| 15 Jan 22 | r05        | DürenDüren | 2 - 3 | Wegberg-BeeckWegberg-Beeck |
| 15 Jan 22 | r05        | Banik OstravaBanik Ostrava | 2 - 4 | Lech PoznanLech Poznan |
| 15 Jan 22 | r05        | SC Rheindorf AltachSC Rheindorf | 1 - 4 | St. GallenSt. Gallen |
| 15 Jan 22 | r05        | FC SionFC Sion | 0 - 2 | ServetteServette |
| 15 Jan 22 | r05        | Lippstadt 08Lippstadt 08 | 4 - 3 | Hessen KasselHessen Kassel |
| 15 Jan 22 | r05        | Universitatea CraiovaUniversitatea | - | ChornomoretsChornomorets |
| 15 Jan 22 | r05        | Dinamo BucurestiDinamo Bucure | 2 - 2 | Farul ConstantaFarul Constan |
| 15 Jan 22 | r05        | FBC MelgarFBC Melgar | 1 - 0 | Deportivo PereiraDeportivo Per |
| 15 Jan 22 | r05        | Carlos A MannucciCarlos A Mann | - | Atlético GrauAtlético Grau |
| 16 Jan 22 | r05        | NK LokomotivaNK Lokomotiva | 2 - 3 | OpatijaOpatija |
| 16 Jan 22 | r05        | DebrecenDebrecen | - | Újpest FCÚjpest FC |
| 16 Jan 22 | r05        | FerencvarosFerencvaros | - | Spartak SuboticaSpartak Subot |
| 16 Jan 22 | r05        | Pärnu JK VaprusPärnu JK Vapr | 0 - 2 | Paide LinnameeskondPaide Linname |
| 16 Jan 22 | r05        | NK VaraždinNK Varaždin | 1 - 2 | CeljeCelje |
| 16 Jan 22 | r05        | DugopoljeDugopolje | 5 - 1 | Iskra DanilovgradIskra Danilov |
| 16 Jan 22 | r05        | Dinamo ZagrebDinamo Zagreb | 4 - 2 | KoperKoper |
| 16 Jan 22 | r05        | Hajduk SplitHajduk Split | 2 - 1 | Siroki BrijegSiroki Brijeg |
| 16 Jan 22 | r05        | NK MariborNK Maribor | 4 - 0 | Triglav KranjTriglav Kranj |
| 16 Jan 22 | r05        | Zaglebie LubinZaglebie Lubi | 1 - 0 | FC VoluntariFC Voluntari |
| 16 Jan 22 | r05        | Galway UnitedGalway United | 1 - 0 | Finn Harps FCFinn Harps FC |
| 16 Jan 22 | r05        | BelgranoBelgrano | 2 - 0 | Unión EspañolaUnión Español |
| 17 Jan 22 | r05        | Defensor SportingDefensor Spor | 0 - 2 | DanubioDanubio |
| 17 Jan 22 | r05        | ZurichZurich | 1 - 1 | Pogon SzczecinPogon Szczeci |
| 17 Jan 22 | r05        | PFC Kuban KrasnodarPFC Kuban Kra | - | Bregalnica ŠtipBregalnica Št |
| 17 Jan 22 | r05        | AktobeAktobe | - | MTK HungariaMTK Hungaria |
| 17 Jan 22 | r05        | Lechia GdańskLechia Gdańsk | - | Mezőkövesdi SEMezőkövesdi S |
| 17 Jan 22 | r05        | Radomiak RadomRadomiak Rado | - | Kyzylzhar SKKyzylzhar SK |
| 17 Jan 22 | r05        | SV SalzburgSV Salzburg | - | Young BoysYoung Boys |
| 17 Jan 22 | r05        | Al-Riffa SCAl-Riffa SC | 1 - 1 | CordobaCordoba |
| 17 Jan 22 | r05        | PeñarolPeñarol | 4 - 0 | Barracas CentralBarracas Cent |
| 18 Jan 22 | r05        | CD Nacional de MadeiraCD Nacional d | 3 - 2 | ÑublenseÑublense |
| 18 Jan 22 | r05        | BelasicaBelasica | 0 - 4 | Akademija PandevAkademija Pan |
| 18 Jan 22 | r05        | RabotnichkiRabotnichki | 2 - 1 | Makedonija GjPMakedonija Gj |
| 18 Jan 22 | r05        | Banik OstravaBanik Ostrava | 1 - 0 | Kisvárda FCKisvárda FC |
| 18 Jan 22 | r05        | Slavia SofiaSlavia Sofia | 0 - 3 | Stal MielecStal Mielec |
| 18 Jan 22 | r05        | NK Istra 1961NK Istra 1961 | 2 - 1 | ŠibenikŠibenik |
| 18 Jan 22 | r05        | Lech PoznanLech Poznan | 4 - 1 | ShkupiShkupi |
| 18 Jan 22 | r05        | Krylya Sovetov SamaraKrylya Soveto | 2 - 0 | Szeged-CsanádSzeged-Csanád |
| 18 Jan 22 | r05        | PFC Kuban KrasnodarPFC Kuban Kra | 0 - 1 | Bregalnica ŠtipBregalnica Št |
| 18 Jan 22 | r05        | Paksi FCPaksi FC | 2 - 0 | FC UfaFC Ufa |
| 18 Jan 22 | r05        | Lechia GdańskLechia Gdańsk | 0 - 2 | ChornomoretsChornomorets |
| 18 Jan 22 | r05        | Levski SofiaLevski Sofia | 1 - 1 | Gornik ZabrzeGornik Zabrze |
| 18 Jan 22 | r05        | SV SalzburgSV Salzburg | 3 - 1 | SV Josko RiedSV Josko Ried |
| 18 Jan 22 | r05        | UnterhachingUnterhaching | - | Sonnenhof GroßaspachSonnenhof Gro |
| 18 Jan 22 | r05        | Young BoysYoung Boys | - | SV SalzburgSV Salzburg |
| 18 Jan 22 | r05        | Cobh RamblersCobh Ramblers | 0 - 3 | DundalkDundalk |
| 19 Jan 22 | r05        | Rakow CzestochowaRakow Czestoc | 3 - 0 | NavbahorNavbahor |
| 19 Jan 22 | r05        | Iskra DanilovgradIskra Danilov | 3 - 3 | OpatijaOpatija |
| 19 Jan 22 | r05        | Viktoria PlzenViktoria Plze | 1 - 1 | Zbrojovka BrnoZbrojovka Brn |
| 19 Jan 22 | r05        | MFK Zemplín MichalovceMFK Zemplín M | 3 - 0 | KosiceKosice |
| 19 Jan 22 | r05        | BeroeBeroe | 1 - 1 | SozopolSozopol |
| 19 Jan 22 | r05        | Legia WarsawLegia Warsaw | 2 - 1 | FC KrasnodarFC Krasnodar |
| 19 Jan 22 | r05        | Slaven Belupo KoprivnicaSlaven Belupo | 1 - 1 | RudešRudeš |
| 19 Jan 22 | r05        | NiecieczaNieciecza | 4 - 1 | MTK HungariaMTK Hungaria |
| 19 Jan 22 | r05        | Cracovia KrakowCracovia Krak | 1 - 2 | Rapid ViennaRapid Vienna |
| 19 Jan 22 | r05        | Wisla PlockWisla Plock | 1 - 1 | Neftçi PFKNeftçi PFK |
| 19 Jan 22 | r05        | FC BaselFC Basel | 3 - 0 | FC Lausanne-SportFC Lausanne-S |
| 19 Jan 22 | r05        | NK BravoNK Bravo | - | GoricaGorica |
| 19 Jan 22 | r05        | Cherno MoreCherno More | 3 - 3 | DobrudzhaDobrudzha |
| 19 Jan 22 | r05        | Mlada BoleslavMlada Bolesla | 4 - 1 | Vysočina JihlavaVysočina Jihl |
| 19 Jan 22 | r05        | Piast GliwicePiast Gliwice | 1 - 4 | Shkendija 79Shkendija 79 |
| 19 Jan 22 | r05        | Dinamo ZagrebDinamo Zagreb | 3 - 0 | DomzaleDomzale |
| 19 Jan 22 | r05        | NK LokomotivaNK Lokomotiva | 7 - 0 | DugopoljeDugopolje |
| 19 Jan 22 | r05        | Slask WroclawSlask Wroclaw | 2 - 1 | TSV HartbergTSV Hartberg |
| 19 Jan 22 | r05        | ZoryaZorya | 1 - 3 | Pogon SzczecinPogon Szczeci |
| 19 Jan 22 | r05        | FC WilFC Wil | 0 - 1 | St. GallenSt. Gallen |
| 19 Jan 22 | r05        | Zenit St PetersburgZenit St Pete | 3 - 0 | Emirates ClubEmirates Club |
| 19 Jan 22 | r05        | FC CopenhagenFC Copenhagen | - | B.93B.93 |
| 19 Jan 22 | r05        | Korona KielceKorona Kielce | 4 - 1 | Puszcza NiepołomicePuszcza Niepo |
| 19 Jan 22 | r05        | DAC 1904 Dunajská StredaDAC 1904 Duna | 2 - 0 | FerencvarosFerencvaros |
| 19 Jan 22 | r05        | Astoria WalldorfAstoria Walld | - | TSV Steinbach HaigerTSV Steinbach |
| 19 Jan 22 | r05        | Wacker NordhausenWacker Nordha | 1 - 4 | Germania HalberstadtGermania Halb |
| 19 Jan 22 | r05        | RaufossRaufoss | - | ElverumElverum |
| 19 Jan 22 | r05        | CD Nacional de MadeiraCD Nacional d | 1 - 2 | Barracas CentralBarracas Cent |
| 20 Jan 22 | r05        | PeñarolPeñarol | 1 - 0 | ÑublenseÑublense |
| 20 Jan 22 | r05        | Energetik-BGU MinskEnergetik-BGU | 4 - 2 | Shakhter SoligorskShakhter Soli |
| 20 Jan 22 | r05        | Legia WarsawLegia Warsaw | 2 - 0 | Riga FCRiga FC |
| 20 Jan 22 | r05        | Odense BKOdense BK | 2 - 1 | FredericiaFredericia |
| 20 Jan 22 | r05        | Orijent 1919Orijent 1919 | 3 - 0 | DomzaleDomzale |
| 20 Jan 22 | r05        | FK Rubin KazanFK Rubin Kaza | 4 - 4 | Fakel VoronezhFakel Voronez |
| 20 Jan 22 | r05        | Gornik LecznaGornik Leczna | 2 - 2 | Zira FKZira FK |
| 20 Jan 22 | r05        | PFC SochiPFC Sochi | 4 - 0 | TomskTomsk |
| 20 Jan 22 | r05        | OsijekOsijek | 3 - 1 | Szombathelyi HaladásSzombathelyi |
| 20 Jan 22 | r05        | Kickers OffenbachKickers Offen | - | ZFC MeuselwitzZFC Meuselwit |
| 20 Jan 22 | r05        | RijekaRijeka | - | Budafoki MTEBudafoki MTE |
| 20 Jan 22 | r05        | AktobeAktobe | 1 - 2 | Polissya ZhytomyrPolissya Zhyt |
| 20 Jan 22 | r05        | Lech PoznanLech Poznan | 1 - 2 | Dinamo BatumiDinamo Batumi |
| 21 Jan 22 | r05        | Radomiak RadomRadomiak Rado | 2 - 3 | MTK HungariaMTK Hungaria |
| 21 Jan 22 | r05        | Wisla KrakowWisla Krakow | 1 - 3 | Banik OstravaBanik Ostrava |
| 21 Jan 22 | r05        | Szeged-CsanádSzeged-Csanád | 2 - 1 | Arsenal TulaArsenal Tula |
| 21 Jan 22 | r05        | Krasava OdintsovoKrasava Odint | 2 - 3 | Peresvet PodolskPeresvet Podo |
| 21 Jan 22 | r05        | Qarabag FKQarabag FK | 0 - 1 | TSC Bačka TopolaTSC Bačka Top |
| 21 Jan 22 | r05        | Dynamo České BudějoviceDynamo České | - | Mezőkövesdi SEMezőkövesdi S |
| 21 Jan 22 | r05        | Rukh BrestRukh Brest | 0 - 0 | Slavia MozyrSlavia Mozyr |
| 21 Jan 22 | r05        | ŠibenikŠibenik | 2 - 0 | OpatijaOpatija |
| 21 Jan 22 | r05        | Sandecja Nowy SaczSandecja Nowy | 3 - 5 | Ruch ChorzowRuch Chorzow |
| 21 Jan 22 | r05        | LiberecLiberec | 4 - 2 | Warta PoznańWarta Poznań |
| 21 Jan 22 | r05        | FC MidtjyllandFC Midtjyllan | 5 - 1 | EsbjergEsbjerg |
| 21 Jan 22 | r05        | RenovaRenova | - | StrugaStruga |
| 21 Jan 22 | r05        | MFK RužomberokMFK Ružombero | 2 - 1 | Podbeskidzie Bielsko-BialPodbeskidzie |
| 21 Jan 22 | r05        | RijekaRijeka | 1 - 1 | SlovackoSlovacko |
| 21 Jan 22 | r05        | Yverdon SportYverdon Sport | 0 - 1 | GjilaniGjilani |
| 21 Jan 22 | r05        | CottbusCottbus | 2 - 1 | Hertha IIHertha II |
| 21 Jan 22 | r05        | Gabala FKGabala FK | 1 - 0 | BorecBorec |
| 21 Jan 22 | r05        | CSKA SofiaCSKA Sofia | 1 - 1 | Stal MielecStal Mielec |
| 21 Jan 22 | r05        | DAC 1904 Dunajská StredaDAC 1904 Duna | - | FK PohronieFK Pohronie |
| 21 Jan 22 | r05        | ElversbergElversberg | 7 - 0 | Rot-Weiß KoblenzRot-Weiß Kobl |
| 21 Jan 22 | r05        | AC HorsensAC Horsens | 2 - 1 | Randers FCRanders FC |
| 21 Jan 22 | r05        | Kisvárda FCKisvárda FC | - | Kyzylzhar SKKyzylzhar SK |
| 21 Jan 22 | r05        | Levski SofiaLevski Sofia | 1 - 1 | BohemiansBohemians |
| 21 Jan 22 | r05        | MontanaMontana | - | Yantra GabrovoYantra Gabrov |
| 21 Jan 22 | r05        | StrugaStruga | - | RenovaRenova |
| 21 Jan 22 | r05        | Metallurg LipetskMetallurg Lip | - | FK AksuFK Aksu |
| 21 Jan 22 | r05        | Wolfsberger ACWolfsberger A | 3 - 3 | Ludogorets RazgradLudogorets Ra |
| 21 Jan 22 | r05        | GrasshoppersGrasshoppers | 1 - 1 | FC WinterthurFC Winterthur |
| 21 Jan 22 | r05        | Cracovia KrakowCracovia Krak | 4 - 2 | Dynamo České BudějoviceDynamo České |
| 21 Jan 22 | r05        | NK AluminijNK Aluminij | 0 - 0 | Budafoki MTEBudafoki MTE |
| 21 Jan 22 | r05        | SKA-KhabarovskSKA-Khabarovs | 2 - 0 | NyíregyházaNyíregyháza |
| 21 Jan 22 | r05        | Slask WroclawSlask Wroclaw | 3 - 2 | Qarabag FKQarabag FK |
| 21 Jan 22 | r05        | NorrbyNorrby | 1 - 2 | HackenHacken |
| 21 Jan 22 | r05        | JammerbugtJammerbugt | - | Vendsyssel FFVendsyssel FF |
| 21 Jan 22 | r05        | Vendsyssel FFVendsyssel FF | - | Aarhus FremadAarhus Fremad |
| 21 Jan 22 | r05        | UT PétangeUT Pétange | 0 - 0 | FolaFola |
| 21 Jan 22 | r05        | BohemiansBohemians | 2 - 3 | St PatricksSt Patricks |
| 22 Jan 22 | r05        | Dandenong Thunder SCDandenong Thu | 4 - 0 | Green Gully SCGreen Gully S |
| 22 Jan 22 | r05        | Baltika KaliningradBaltika Kalin | 1 - 0 | Lokomotiv SofiaLokomotiv Sof |
| 22 Jan 22 | r05        | Mlada BoleslavMlada Bolesla | - | PribramPribram |
| 22 Jan 22 | r05        | SJK SeinajokiSJK Seinajoki | 2 - 0 | Paide LinnameeskondPaide Linname |
| 22 Jan 22 | r05        | Dinamo MinskDinamo Minsk | 1 - 1 | Isloch Minsk RaionIsloch Minsk |
| 22 Jan 22 | r05        | Kolding IFKolding IF | - | MiddelfartMiddelfart |
| 22 Jan 22 | r05        | LíšeňLíšeň | - | Slovan BratislavaSlovan Bratis |
| 22 Jan 22 | r05        | OsijekOsijek | 3 - 0 | Tabor SežanaTabor Sežana |
| 22 Jan 22 | r05        | Viktoria PlzenViktoria Plze | 0 - 1 | Mlada BoleslavMlada Bolesla |
| 22 Jan 22 | r05        | SV SalzburgSV Salzburg | - | Sparta PragueSparta Prague |
| 22 Jan 22 | r05        | Slavoj VyšehradSlavoj Vyšehr | 0 - 2 | Viktoria ŽižkovViktoria Žižk |
| 22 Jan 22 | r05        | DubravaDubrava | 3 - 2 | SesveteSesvete |
| 22 Jan 22 | r05        | NK Istra 1961NK Istra 1961 | 1 - 0 | DugopoljeDugopolje |
| 22 Jan 22 | r05        | GomelGomel | 4 - 0 | FC Belshina BobruiskFC Belshina B |
| 22 Jan 22 | r05        | Miedz LegnicaMiedz Legnica | - | Chrobry GłogówChrobry Głogó |
| 22 Jan 22 | r05        | BATE BorisovBATE Borisov | 3 - 0 | FC SlutskFC Slutsk |
| 22 Jan 22 | r05        | Chrobry GłogówChrobry Głogó | 1 - 3 | Miedz LegnicaMiedz Legnica |
| 22 Jan 22 | r05        | FC Flora Tallinn IIFC Flora Tall | 1 - 1 | Pärnu JalgpalliklubiPärnu Jalgpal |
| 22 Jan 22 | r05        | HNK GoricaHNK Gorica | 1 - 3 | RudešRudeš |
| 22 Jan 22 | r05        | Zaglebie SosnowiecZaglebie Sosn | 0 - 1 | Puszcza NiepołomicePuszcza Niepo |
| 22 Jan 22 | r05        | NykøbingNykøbing | 3 - 1 | HillerødHillerød |
| 22 Jan 22 | r05        | Young BoysYoung Boys | - | FC WinterthurFC Winterthur |
| 22 Jan 22 | r05        | KøgeKøge | 3 - 0 | KFUM RoskildeKFUM Roskilde |
| 22 Jan 22 | r05        | Dila GoriDila Gori | 2 - 2 | SioniSioni |
| 22 Jan 22 | r05        | Dunav RuseDunav Ruse | 2 - 2 | DobrudzhaDobrudzha |
| 22 Jan 22 | r05        | Fremad AmagerFremad Amager | 4 - 1 | AB GladsaxeAB Gladsaxe |
| 22 Jan 22 | r05        | Unirea DejUnirea Dej | 0 - 1 | FC HermannstadtFC Hermannsta |
| 22 Jan 22 | r05        | Widzew LodzWidzew Lodz | 1 - 2 | Chojniczanka ChojniceChojniczanka |
| 22 Jan 22 | r05        | Hertha ZehlendorfHertha Zehlen | 2 - 2 | Tennis Borussia BerlinTennis Boruss |
| 22 Jan 22 | r05        | JastrzębieJastrzębie | 1 - 2 | GKS KatowiceGKS Katowice |
| 22 Jan 22 | r05        | KoperKoper | 2 - 0 | SV KapfenbergSV Kapfenberg |
| 22 Jan 22 | r05        | Næstved BKNæstved BK | 3 - 1 | RoskildeRoskilde |
| 22 Jan 22 | r05        | BrøndbyBrøndby | 1 - 4 | LyngbyLyngby |
| 22 Jan 22 | r05        | DjurgaardenDjurgaarden | 3 - 0 | Vaesteraas SKVaesteraas SK |
| 22 Jan 22 | r05        | HalmstadHalmstad | 2 - 0 | Falkenbergs FFFalkenbergs F |
| 22 Jan 22 | r05        | River PlateRiver Plate | 2 - 1 | Deportivo MaldonadoDeportivo Mal |
| 22 Jan 22 | r05        | WanderersWanderers | 0 - 0 | RentistasRentistas |
| 22 Jan 22 | r05        | LandskronaLandskrona | 2 - 3 | FC HelsingoerFC Helsingoer |
| 22 Jan 22 | r05        | Lokomotiv PlovdivLokomotiv Plo | 3 - 1 | Maritsa PlovdivMaritsa Plovd |
| 22 Jan 22 | r05        | Slavia SofiaSlavia Sofia | 0 - 5 | Metalist KharkivMetalist Khar |
| 22 Jan 22 | r05        | Hajduk SplitHajduk Split | 1 - 1 | Velez MostarVelez Mostar |
| 22 Jan 22 | r05        | Longford TownLongford Town | 1 - 1 | ShamrockShamrock |
| 22 Jan 22 | r05        | Neman GrodnoNeman Grodno | 3 - 3 | Dynamo BrestDynamo Brest |
| 22 Jan 22 | r05        | Peresvet PodolskPeresvet Podo | 5 - 2 | FC Kvant ObninskFC Kvant Obni |
| 22 Jan 22 | r05        | Rapid ViennaRapid Vienna | 1 - 2 | Pogon SzczecinPogon Szczeci |
| 22 Jan 22 | r05        | Sumgayit FKSumgayit FK | 1 - 2 | ShkupiShkupi |
| 22 Jan 22 | r05        | WexfordWexford | 0 - 2 | Shelbourne FCShelbourne FC |
| 22 Jan 22 | r05        | VMFD ZalgirisVMFD Zalgiris | 2 - 2 | Rīgas Futbola SkolaRīgas Futbola |
| 22 Jan 22 | r05        | Chemnitzer FCChemnitzer FC | 1 - 1 | SpVgg BayreuthSpVgg Bayreut |
| 22 Jan 22 | r05        | BełchatówBełchatów | 1 - 0 | Znicz PruszkówZnicz Pruszkó |
| 22 Jan 22 | r05        | FC Levadia TallinnFC Levadia Ta | 2 - 0 | Tallinna JK LegionTallinna JK L |
| 22 Jan 22 | r05        | Makedonija GjPMakedonija Gj | 1 - 0 | Spartak VarnaSpartak Varna |
| 22 Jan 22 | r05        | OpatijaOpatija | 1 - 3 | KustošijaKustošija |
| 22 Jan 22 | r05        | FA 2000FA 2000 | 3 - 2 | VanløseVanløse |
| 22 Jan 22 | r05        | KuPS KuopioKuPS Kuopio | 5 - 1 | KTPKTP |
| 22 Jan 22 | r05        | Dynamo BrestDynamo Brest | - | Neman GrodnoNeman Grodno |
| 22 Jan 22 | r05        | FC HomburgFC Homburg | 4 - 1 | UNA StrassenUNA Strassen |
| 22 Jan 22 | r05        | Hamburg IIHamburg II | 3 - 3 | Eintracht Norderstedt 03Eintracht Nor |
| 22 Jan 22 | r05        | FV IllertissenFV Illertisse | 1 - 2 | FC MemmingenFC Memmingen |
| 22 Jan 22 | r05        | FC LvivFC Lviv | 0 - 0 | TSV HartbergTSV Hartberg |
| 22 Jan 22 | r05        | Nurnberg IINurnberg II | 0 - 1 | Sonnenhof GroßaspachSonnenhof Gro |
| 22 Jan 22 | r05        | Olimpija LjubljanaOlimpija Ljub | 2 - 3 | Szombathelyi HaladásSzombathelyi |
| 22 Jan 22 | r05        | Paksi FCPaksi FC | - | PécsPécs |
| 22 Jan 22 | r05        | Phönix LübeckPhönix Lübeck | - | TodesfeldeTodesfelde |
| 22 Jan 22 | r05        | SV Josko RiedSV Josko Ried | 6 - 0 | Lask Juniors LinzLask Juniors |
| 22 Jan 22 | r05        | Rielasingen-ArlenRielasingen-A | 0 - 1 | TSG BalingenTSG Balingen |
| 22 Jan 22 | r05        | FC SchweinfurtFC Schweinfur | 8 - 0 | Bayern AlzenauBayern Alzena |
| 22 Jan 22 | r05        | SiriusSirius | 2 - 1 | OerebroOerebro |
| 22 Jan 22 | r05        | Slaven Belupo KoprivnicaSlaven Belupo | 1 - 0 | NK Inter ZaprešićNK Inter Zapr |
| 22 Jan 22 | r05        | Wisla KrakowWisla Krakow | - | Makedonija GjPMakedonija Gj |
| 22 Jan 22 | r05        | Zenit St PetersburgZenit St Pete | 2 - 2 | Botev PlovdivBotev Plovdiv |
| 22 Jan 22 | r05        | ZurichZurich | 1 - 0 | FC WilFC Wil |
| 22 Jan 22 | r05        | Cobh RamblersCobh Ramblers | 0 - 5 | Waterford FCWaterford FC |
| 22 Jan 22 | r05        | Rot-Weiß ErfurtRot-Weiß Erfu | 1 - 1 | Hessen KasselHessen Kassel |
| 22 Jan 22 | r05        | HJK HelsinkiHJK Helsinki | 3 - 0 | IlvesIlves |
| 22 Jan 22 | r05        | KPVKPV | 1 - 5 | VPSVPS |
| 22 Jan 22 | r05        | FC Krasnodar-2FC Krasnodar- | 5 - 2 | Hebar PazardzhikHebar Pazardz |
| 22 Jan 22 | r05        | LucerneLucerne | 2 - 2 | SC Rheindorf AltachSC Rheindorf |
| 22 Jan 22 | r05        | FC NordsjællandFC Nordsjælla | 1 - 2 | ViborgViborg |
| 22 Jan 22 | r05        | VaduzVaduz | 4 - 0 | Austria LustenauAustria Luste |
| 22 Jan 22 | r05        | LuganoLugano | 1 - 0 | ChiassoChiasso |
| 22 Jan 22 | r05        | Paris FCParis FC | 3 - 4 | NiortNiort |
| 22 Jan 22 | r05        | ŽarkovoŽarkovo | 2 - 1 | NK LokomotivaNK Lokomotiva |
| 22 Jan 22 | r05        | LASKLASK | 1 - 2 | NK MariborNK Maribor |
| 22 Jan 22 | r05        | FC LieferingFC Liefering | 2 - 3 | First ViennaFirst Vienna |
| 22 Jan 22 | r05        | FC BaselFC Basel | 3 - 1 | Neuchâtel XamaxNeuchâtel Xam |
| 22 Jan 22 | r05        | Lechia GdańskLechia Gdańsk | 2 - 1 | Terek GroznyTerek Grozny |
| 22 Jan 22 | r05        | ChornomoretsChornomorets | 4 - 0 | FC PrishtinaFC Prishtina |
| 22 Jan 22 | r05        | CukarickiCukaricki | 1 - 0 | PFC Kuban KrasnodarPFC Kuban Kra |
| 22 Jan 22 | r05        | DroghedaDrogheda | 1 - 1 | Derry CityDerry City |
| 22 Jan 22 | r05        | Gornik ZabrzeGornik Zabrze | 2 - 1 | Baltika KaliningradBaltika Kalin |
| 22 Jan 22 | r05        | NiecieczaNieciecza | 2 - 0 | KolubaraKolubara |
| 22 Jan 22 | r05        | TepliceTeplice | 2 - 1 | Rapid ViennaRapid Vienna |
| 22 Jan 22 | r05        | JablonecJablonec | - | FK RostovFK Rostov |
| 22 Jan 22 | r05        | Lech PoznanLech Poznan | 4 - 1 | NŠ MuraNŠ Mura |
| 22 Jan 22 | r05        | Krylya Sovetov SamaraKrylya Soveto | 1 - 1 | CeljeCelje |
| 22 Jan 22 | r05        | Jeunesse EschJeunesse Esch | 1 - 1 | Swift HesperangeSwift Hespera |
| 22 Jan 22 | r05        | FC AarauFC Aarau | 9 - 0 | BellinzonaBellinzona |
| 22 Jan 22 | r05        | Dynamo KievDynamo Kiev | 4 - 0 | Racing FC Union LuxembourRacing FC Uni |
| 22 Jan 22 | r05        | Treaty UnitedTreaty United | 0 - 2 | Finn Harps FCFinn Harps FC |
| 22 Jan 22 | r05        | CD Nacional de MadeiraCD Nacional d | 0 - 0 | PeñarolPeñarol |
| 23 Jan 22 | r05        | SarmientoSarmiento | - | Santiago WanderersSantiago Wand |
| 23 Jan 22 | r05        | FK Rubin KazanFK Rubin Kaza | 0 - 0 | Wisla PlockWisla Plock |
| 23 Jan 22 | r05        | Fakel VoronezhFakel Voronez | 0 - 0 | Nizhny NovgorodNizhny Novgor |
| 23 Jan 22 | r05        | Phnom Penh CrownPhnom Penh Cr | 3 - 0 | Kirivong Sok Sen CheyKirivong Sok |
| 23 Jan 22 | r05        | TomskTomsk | 2 - 2 | FC Forte TaganrogFC Forte Taga |
| 23 Jan 22 | r05        | Silkeborg IFSilkeborg IF | - | RaufossRaufoss |
| 23 Jan 22 | r05        | FredericiaFredericia | 6 - 0 | NæsbyNæsby |
| 23 Jan 22 | r05        | FC KrasnodarFC Krasnodar | 3 - 2 | MSK ZilinaMSK Zilina |
| 23 Jan 22 | r05        | Rakow CzestochowaRakow Czestoc | - | RabotnichkiRabotnichki |
| 23 Jan 22 | r05        | SoroksárSoroksár | - | DiosgyorDiosgyor |
| 23 Jan 22 | r05        | Warta PoznańWarta Poznań | 1 - 3 | Shkendija 79Shkendija 79 |
| 23 Jan 22 | r05        | SV HeimstettenSV Heimstette | 0 - 2 | AalenAalen |
| 23 Jan 22 | r05        | Piast GliwicePiast Gliwice | 1 - 1 | Radnički NišRadnički Niš |
| 23 Jan 22 | r05        | Videoton FC FehervarVideoton FC F | - | GyirmótGyirmót |
| 23 Jan 22 | r05        | DiosgyorDiosgyor | 2 - 2 | KosiceKosice |
| 23 Jan 22 | r05        | Dinamo ZagrebDinamo Zagreb | 4 - 3 | Sturm GrazSturm Graz |
| 23 Jan 22 | r05        | TSV Rain am LechTSV Rain am L | 1 - 3 | Schwaben AugsburgSchwaben Augs |
| 23 Jan 22 | r05        | SchaffhausenSchaffhausen | 1 - 3 | St. GallenSt. Gallen |
| 23 Jan 22 | r05        | ZoryaZorya | 2 - 2 | AktobeAktobe |
| 23 Jan 22 | r05        | Gazovik OrenburgGazovik Orenb | 1 - 4 | FC UfaFC Ufa |
| 23 Jan 22 | r05        | FC OlexandriaFC Olexandria | 1 - 2 | Zaglebie LubinZaglebie Lubi |
| 23 Jan 22 | r05        | Lechia GdańskLechia Gdańsk | - | Dinamo BatumiDinamo Batumi |
| 23 Jan 22 | r05        | Chayka PeschanokopskoyeChayka Pescha | 1 - 0 | GjilaniGjilani |
| 23 Jan 22 | r05        | Nomme KaljuNomme Kalju | 5 - 0 | Trans NarvaTrans Narva |
| 23 Jan 22 | r05        | Wisla PlockWisla Plock | 2 - 2 | Radnički 1923Radnički 1923 |
| 23 Jan 22 | r05        | Novi PazarNovi Pazar | 1 - 1 | Akademija PandevAkademija Pan |
| 23 Jan 22 | r05        | Orlando CityOrlando City | - | New York CityNew York City |
| 23 Jan 22 | r05        | Royal PariRoyal Pari | 3 - 1 | Real Santa CruzReal Santa Cr |
| 23 Jan 22 | r05        | BloomingBlooming | 1 - 2 | Oriente PetroleroOriente Petro |
| 24 Jan 22 | r05        | Krylya Sovetov SamaraKrylya Soveto | 2 - 0 | Radnik SurdulicaRadnik Surdul |
| 24 Jan 22 | r05        | Prey VengPrey Veng | 3 - 1 | Boeung KetBoeung Ket |
| 24 Jan 22 | r05        | CibaliaCibalia | 0 - 1 | Iskra DanilovgradIskra Danilov |
| 24 Jan 22 | r05        | CSKA MoscowCSKA Moscow | 0 - 1 | F91 DudelangeF91 Dudelange |
| 24 Jan 22 | r05        | FC CopenhagenFC Copenhagen | 3 - 2 | FC HelsingoerFC Helsingoer |
| 24 Jan 22 | r05        | FC Metalist KharkivFC Metalist K | - | LiberecLiberec |
| 24 Jan 22 | r05        | FC AstanaFC Astana | - | TSC Bačka TopolaTSC Bačka Top |
| 24 Jan 22 | r05        | Hradec KrálovéHradec Králov | 1 - 1 | Veres RivneVeres Rivne |
| 24 Jan 22 | r05        | Zira FKZira FK | 1 - 1 | Bregalnica ŠtipBregalnica Št |
| 24 Jan 22 | r05        | Austria ViennaAustria Vienn | - | BohemiansBohemians |
| 24 Jan 22 | r05        | Tatran Liptovský MikulášTatran Liptov | - | FC LvivFC Lviv |
| 24 Jan 22 | r05        | Metallurg LipetskMetallurg Lip | 0 - 0 | FC SKA Rostov-on-DonFC SKA Rostov |
| 24 Jan 22 | r05        | Wolfsberger ACWolfsberger A | 1 - 4 | Shakhtar DonetskShakhtar Done |
| 24 Jan 22 | r05        | Dynamo České BudějoviceDynamo České | 4 - 2 | Khimki FKKhimki FK |
| 24 Jan 22 | r05        | CD Nacional de MadeiraCD Nacional d | 1 - 0 | SarmientoSarmiento |
| 24 Jan 22 | r05        | DanubioDanubio | 0 - 1 | Barracas CentralBarracas Cent |
| 25 Jan 22 | r05        | PeñarolPeñarol | 2 - 0 | Santiago WanderersSantiago Wand |
| 25 Jan 22 | r05        | Zenit St PetersburgZenit St Pete | 5 - 0 | MSK ZilinaMSK Zilina |
| 25 Jan 22 | r05        | Shakhter KaragandaShakhter Kara | - | GjilaniGjilani |
| 25 Jan 22 | r05        | PFC Kuban KrasnodarPFC Kuban Kra | - | Olimp-DolgoprudnyOlimp-Dolgopr |
| 25 Jan 22 | r05        | DubnicaDubnica | 1 - 1 | TřinecTřinec |
| 25 Jan 22 | r05        | Odra OpoleOdra Opole | 2 - 2 | Chojniczanka ChojniceChojniczanka |
| 25 Jan 22 | r05        | Tatran Liptovský MikulášTatran Liptov | - | Qarabag FKQarabag FK |
| 25 Jan 22 | r05        | Austria ViennaAustria Vienn | 0 - 0 | PFC SochiPFC Sochi |
| 25 Jan 22 | r05        | Lokomotiv SofiaLokomotiv Sof | 1 - 1 | DukagjiniDukagjini |
| 25 Jan 22 | r05        | Riga FCRiga FC | 2 - 1 | Slovan BratislavaSlovan Bratis |
| 25 Jan 22 | r05        | Skive IKSkive IK | 0 - 5 | Randers FCRanders FC |
| 25 Jan 22 | r05        | Slavia SofiaSlavia Sofia | 1 - 2 | TepliceTeplice |
| 25 Jan 22 | r05        | Partizan BelgradePartizan Belg | 2 - 1 | TikvešTikveš |
| 25 Jan 22 | r05        | DundalkDundalk | 1 - 5 | BohemiansBohemians |
| 25 Jan 22 | r05        | Mlada BoleslavMlada Bolesla | 2 - 2 | Dukla PrahaDukla Praha |
| 25 Jan 22 | r05        | Randers FCRanders FC | - | RaufossRaufoss |
| 25 Jan 22 | r05        | Hajduk SplitHajduk Split | 4 - 2 | NK VaraždinNK Varaždin |
| 25 Jan 22 | r05        | Olimpija LjubljanaOlimpija Ljub | 3 - 0 | SlovackoSlovacko |
| 25 Jan 22 | r05        | BeroeBeroe | 1 - 3 | Gazovik OrenburgGazovik Orenb |
| 25 Jan 22 | r05        | Akron TolyattiAkron Tolyatt | 2 - 1 | Proleter Novi SadProleter Novi |
| 25 Jan 22 | r05        | CeljeCelje | 1 - 0 | PFC Kuban KrasnodarPFC Kuban Kra |
| 25 Jan 22 | r05        | NK MariborNK Maribor | 1 - 1 | Crvena ZvezdaCrvena Zvezda |
| 25 Jan 22 | r05        | EsbjergEsbjerg | 2 - 0 | ThistedThisted |
| 25 Jan 22 | r05        | MurciaMurcia | 1 - 3 | Dynamo KievDynamo Kiev |
| 25 Jan 22 | r05        | LysengLyseng | 1 - 0 | Aarhus FremadAarhus Fremad |
| 25 Jan 22 | r05        | VfR GarchingVfR Garching | 2 - 1 | TSV BuchbachTSV Buchbach |
| 25 Jan 22 | r05        | Jeunesse EschJeunesse Esch | 1 - 1 | Mondorf-les-BainsMondorf-les-B |
| 25 Jan 22 | r05        | Derry CityDerry City | 5 - 0 | InstituteInstitute |
| 25 Jan 22 | r05        | Liverpool MontevideoLiverpool Mon | 0 - 2 | Instituto ACCInstituto ACC |
| 26 Jan 22 | r05        | CSKA SofiaCSKA Sofia | - | TSV HartbergTSV Hartberg |
| 26 Jan 22 | r05        | VisakhaVisakha | 3 - 2 | Boeung KetBoeung Ket |
| 26 Jan 22 | r05        | Metalist KharkivMetalist Khar | 1 - 1 | Radomiak RadomRadomiak Rado |
| 26 Jan 22 | r05        | Podbeskidzie Bielsko-BialPodbeskidzie | 2 - 2 | GKS KatowiceGKS Katowice |
| 26 Jan 22 | r05        | Arka GdyniaArka Gdynia | 1 - 0 | Olimpia GrudziądzOlimpia Grudz |
| 26 Jan 22 | r05        | Floridsdorfer ACFloridsdorfer | - | ŠKF SereďŠKF Sereď |
| 26 Jan 22 | r05        | NK MariborNK Maribor | 1 - 2 | VoždovacVoždovac |
| 26 Jan 22 | r05        | Trans NarvaTrans Narva | - | Maardu LinnameeskondMaardu Linnam |
| 26 Jan 22 | r05        | FC Anzhi MakhachkalaFC Anzhi Makh | 6 - 1 | PFC Dynamo StavropolPFC Dynamo St |
| 26 Jan 22 | r05        | KoperKoper | 0 - 2 | Rudar PrijedorRudar Prijedo |
| 26 Jan 22 | r05        | MFK RužomberokMFK Ružombero | 2 - 1 | Radnički NišRadnički Niš |
| 26 Jan 22 | r05        | Spartak SuboticaSpartak Subot | 0 - 2 | KarvinaKarvina |
| 26 Jan 22 | r05        | Strumska SlavaStrumska Slav | 0 - 2 | Sportist SvogeSportist Svog |
| 26 Jan 22 | r05        | TeteksTeteks | 4 - 3 | SkopjeSkopje |
| 26 Jan 22 | r05        | Vejle BoldklubVejle Boldklu | - | EsbjergEsbjerg |
| 26 Jan 22 | r05        | WanderersWanderers | 3 - 1 | Albion FCAlbion FC |
| 26 Jan 22 | r05        | Wisla KrakowWisla Krakow | - | RabotnichkiRabotnichki |
| 26 Jan 22 | r05        | KazincbarcikaKazincbarcika | 1 - 2 | KosiceKosice |
| 26 Jan 22 | r05        | Ural S.RUral S.R | 1 - 1 | Pyunik YerevanPyunik Yereva |
| 26 Jan 22 | r05        | SesveteSesvete | 2 - 1 | OpatijaOpatija |
| 26 Jan 22 | r05        | Siroki BrijegSiroki Brijeg | 0 - 3 | Velez MostarVelez Mostar |
| 26 Jan 22 | r05        | Zaglebie LubinZaglebie Lubi | 3 - 1 | Metalac GMMetalac GM |
| 26 Jan 22 | r05        | FC LvivFC Lviv | 0 - 0 | Dinamo TbilisiDinamo Tbilis |
| 26 Jan 22 | r05        | ChornomoretsChornomorets | 1 - 1 | ShkupiShkupi |
| 26 Jan 22 | r05        | CukarickiCukaricki | 1 - 1 | NŠ MuraNŠ Mura |
| 26 Jan 22 | r05        | GomelGomel | 4 - 1 | FC Dnepr MogilevFC Dnepr Mogi |
| 26 Jan 22 | r05        | FC PrishtinaFC Prishtina | 2 - 2 | AtyrauAtyrau |
| 26 Jan 22 | r05        | JablonecJablonec | - | Bodoe/GlimtBodoe/Glimt |
| 26 Jan 22 | r05        | Gornik ZabrzeGornik Zabrze | 2 - 2 | FC OlexandriaFC Olexandria |
| 26 Jan 22 | r05        | Korona KielceKorona Kielce | 1 - 0 | Skra CzęstochowaSkra Częstoch |
| 26 Jan 22 | r05        | Sparta PragueSparta Prague | 2 - 3 | Lok. MoscowLok. Moscow |
| 26 Jan 22 | r05        | Union BerlinUnion Berlin | - | AueAue |
| 26 Jan 22 | r05        | DubravaDubrava | 3 - 2 | KustošijaKustošija |
| 26 Jan 22 | r05        | RijekaRijeka | 3 - 0 | Triglav KranjTriglav Kranj |
| 26 Jan 22 | r05        | Slask WroclawSlask Wroclaw | 0 - 2 | VojvodinaVojvodina |
| 26 Jan 22 | r05        | FV IllertissenFV Illertisse | 0 - 2 | AalenAalen |
| 26 Jan 22 | r05        | UT PétangeUT Pétange | 2 - 2 | FC 03 DifferdangeFC 03 Differd |
| 26 Jan 22 | r05        | Athlone TownAthlone Town | 1 - 2 | SligoSligo |
| 26 Jan 22 | r05        | PortuguesaPortuguesa | 0 - 1 | Monagas S.C.Monagas S.C. |
| 26 Jan 22 | r05        | PeñarolPeñarol | 1 - 0 | CD Nacional de MadeiraCD Nacional d |
| 26 Jan 22 | r05        | Club Universitario de SucClub Universi | 1 - 2 | Real TomayapoReal Tomayapo |
| 26 Jan 22 | r05        | Metropolitanos F.C.Metropolitano | 2 - 1 | Puerto Cabello F.C.Puerto Cabell |
| 27 Jan 22 | r05        | Estudiantes de la PlataEstudiantes d | 1 - 2 | San LorenzoSan Lorenzo |
| 27 Jan 22 | r05        | Inter MiamiInter Miami | 4 - 0 | UniversitarioUniversitario |
| 27 Jan 22 | r05        | Portland TimbersPortland Timb | 0 - 0 | Seattle Sounders FCSeattle Sound |
| 27 Jan 22 | r05        | Saburtalo TbilisiSaburtalo Tbi | 0 - 0 | SioniSioni |
| 27 Jan 22 | r05        | Dynamo KievDynamo Kiev | 1 - 1 | Bodoe/GlimtBodoe/Glimt |
| 27 Jan 22 | r05        | KarlsruheKarlsruhe | - | ElversbergElversberg |
| 27 Jan 22 | r05        | OsasunaOsasuna | 0 - 1 | AlavesAlaves |
| 27 Jan 22 | r05        | VikingViking | 2 - 2 | JablonecJablonec |
| 27 Jan 22 | r05        | Ludogorets Razgrad IILudogorets Ra | 3 - 0 | Yantra GabrovoYantra Gabrov |
| 27 Jan 22 | r05        | SC CambuurSC Cambuur | 0 - 1 | SC Heracles AlmeloSC Heracles A |
| 27 Jan 22 | r05        | DAC 1904 Dunajská StredaDAC 1904 Duna | 1 - 1 | TSC Bačka TopolaTSC Bačka Top |
| 27 Jan 22 | r05        | FC KolnFC Koln | 2 - 2 | Schalke 04Schalke 04 |
| 27 Jan 22 | r05        | JablonecJablonec | - | FK RostovFK Rostov |
| 27 Jan 22 | r05        | Metalist KharkivMetalist Khar | 0 - 0 | Warta PoznańWarta Poznań |
| 27 Jan 22 | r05        | Silkeborg IFSilkeborg IF | 2 - 0 | Odense BKOdense BK |
| 27 Jan 22 | r05        | Lokomotiv PlovdivLokomotiv Plo | 0 - 0 | Etar Veliko TarnovoEtar Veliko T |
| 27 Jan 22 | r05        | Vejle BoldklubVejle Boldklu | 1 - 1 | Jagiellonia BialystokJagiellonia B |
| 27 Jan 22 | r05        | FK AksuFK Aksu | - | Bregalnica ŠtipBregalnica Št |
| 27 Jan 22 | r05        | LlapiLlapi | 2 - 0 | Akademija PandevAkademija Pan |
| 27 Jan 22 | r05        | Wolfsberger ACWolfsberger A | 1 - 1 | BohemiansBohemians |
| 27 Jan 22 | r05        | AugsburgAugsburg | 3 - 3 | Jahn RegensburgJahn Regensbu |
| 27 Jan 22 | r05        | BochumBochum | 0 - 2 | Fortuna DüsseldorfFortuna Düsse |
| 27 Jan 22 | r05        | MainzMainz | 0 - 1 | Ein FrankfurtEin Frankfurt |
| 27 Jan 22 | r05        | NurnbergNurnberg | 9 - 0 | PribramPribram |
| 27 Jan 22 | r05        | FC OlexandriaFC Olexandria | 0 - 1 | BallkaniBallkani |
| 27 Jan 22 | r05        | Piast GliwicePiast Gliwice | 3 - 0 | Arda KardzhaliArda Kardzhal |
| 27 Jan 22 | r05        | MoldeMolde | 1 - 0 | F91 DudelangeF91 Dudelange |
| 27 Jan 22 | r05        | Rakow CzestochowaRakow Czestoc | 3 - 2 | ZoryaZorya |
| 27 Jan 22 | r05        | Ludogorets RazgradLudogorets Ra | 2 - 1 | Wisla PlockWisla Plock |
| 27 Jan 22 | r05        | Stal MielecStal Mielec | - | Makedonija GjPMakedonija Gj |
| 27 Jan 22 | r05        | NiecieczaNieciecza | 1 - 1 | Radnik SurdulicaRadnik Surdul |
| 27 Jan 22 | r05        | Gornik LecznaGornik Leczna | 0 - 0 | Novi PazarNovi Pazar |
| 27 Jan 22 | r05        | LiberecLiberec | 3 - 1 | Shkendija 79Shkendija 79 |
| 27 Jan 22 | r05        | AIKAIK | 1 - 2 | SollentunaSollentuna |
| 27 Jan 22 | r05        | HackenHacken | 2 - 3 | FredrikstadFredrikstad |
| 27 Jan 22 | r05        | Royal PariRoyal Pari | 1 - 1 | Real Santa CruzReal Santa Cr |
| 28 Jan 22 | r05        | Peresvet PodolskPeresvet Podo | 1 - 2 | Saturn RamenskoyeSaturn Ramens |
| 28 Jan 22 | r05        | Arka GdyniaArka Gdynia | 0 - 2 | Odra OpoleOdra Opole |
| 28 Jan 22 | r05        | Peninsula Power FCPeninsula Pow | 3 - 2 | Newcastle Olympic FCNewcastle Oly |
| 28 Jan 22 | r05        | Dynamo České BudějoviceDynamo České | - | Cracovia KrakowCracovia Krak |
| 28 Jan 22 | r05        | FK RostovFK Rostov | 1 - 2 | StuttgartStuttgart |
| 28 Jan 22 | r05        | GalatasarayGalatasaray | 2 - 6 | TuzlasporTuzlaspor |
| 28 Jan 22 | r05        | HamburgHamburg | 1 - 5 | FC MidtjyllandFC Midtjyllan |
| 28 Jan 22 | r05        | Perth GloryPerth Glory | 1 - 0 | Gwelup CroatiaGwelup Croati |
| 28 Jan 22 | r05        | Perth SCPerth SC | 3 - 1 | Balcatta FCBalcatta FC |
| 28 Jan 22 | r05        | Randers FCRanders FC | - | ElfsborgElfsborg |
| 28 Jan 22 | r05        | Zaglebie SosnowiecZaglebie Sosn | 1 - 1 | Sandecja Nowy SaczSandecja Nowy |
| 28 Jan 22 | r05        | Austria ViennaAustria Vienn | 3 - 1 | Hradec KrálovéHradec Králov |
| 28 Jan 22 | r05        | Dynamo BrestDynamo Brest | 0 - 1 | Neman GrodnoNeman Grodno |
| 28 Jan 22 | r05        | Polissya ZhytomyrPolissya Zhyt | - | VardarVardar |
| 28 Jan 22 | r05        | Riga FCRiga FC | 2 - 1 | MSK ZilinaMSK Zilina |
| 28 Jan 22 | r05        | DomzaleDomzale | 3 - 1 | SlovackoSlovacko |
| 28 Jan 22 | r05        | Legia WarsawLegia Warsaw | 4 - 0 | Tychy 71Tychy 71 |
| 28 Jan 22 | r05        | Widzew LodzWidzew Lodz | 1 - 0 | Ruch ChorzowRuch Chorzow |
| 28 Jan 22 | r05        | BrøndbyBrøndby | 2 - 1 | ViborgViborg |
| 28 Jan 22 | r05        | ECU Joondalup SCECU Joondalup | 3 - 2 | Bayswater City Soccer CluBayswater Cit |
| 28 Jan 22 | r05        | Dynamo DresdenDynamo Dresde | - | Mlada BoleslavMlada Bolesla |
| 28 Jan 22 | r05        | BeroeBeroe | 1 - 2 | SC Dnipro-1SC Dnipro-1 |
| 28 Jan 22 | r05        | SV Josko RiedSV Josko Ried | 5 - 2 | SKU AmstettenSKU Amstetten |
| 28 Jan 22 | r05        | Spartak MoscowSpartak Mosco | 2 - 2 | Slovan BratislavaSlovan Bratis |
| 28 Jan 22 | r05        | TepliceTeplice | 1 - 1 | FC LvivFC Lviv |
| 28 Jan 22 | r05        | Austria Vienna (Am)Austria Vienn | 3 - 1 | Lask Juniors LinzLask Juniors |
| 28 Jan 22 | r05        | Bourg-PeronnasBourg-Peronna | 3 - 0 | GrenobleGrenoble |
| 28 Jan 22 | r05        | CSKA SofiaCSKA Sofia | 3 - 1 | Dinamo MoscowDinamo Moscow |
| 28 Jan 22 | r05        | DjurgaardenDjurgaarden | - | METTA Latvijas UniversitāMETTA Latvija |
| 28 Jan 22 | r05        | SV LafnitzSV Lafnitz | - | TSV HartbergTSV Hartberg |
| 28 Jan 22 | r05        | Shakhtar DonetskShakhtar Done | - | Shakhter SoligorskShakhter Soli |
| 28 Jan 22 | r05        | Bayern Munich IIBayern Munich | 0 - 2 | SSV UlmSSV Ulm |
| 28 Jan 22 | r05        | Metallurg LipetskMetallurg Lip | 0 - 2 | Chayka PeschanokopskoyeChayka Pescha |
| 28 Jan 22 | r05        | Malmo FFMalmo FF | 2 - 2 | JammerbugtJammerbugt |
| 28 Jan 22 | r05        | Valencia MestallaValencia Mest | 2 - 1 | FC LieferingFC Liefering |
| 28 Jan 22 | r05        | Galway UnitedGalway United | 2 - 0 | St PatricksSt Patricks |
| 28 Jan 22 | r05        | FK HaugesundFK Haugesund | 1 - 1 | ASANE FOTBALLASANE FOTBALL |
| 28 Jan 22 | r05        | Tatran Liptovský MikulášTatran Liptov | - | Spartak SuboticaSpartak Subot |
| 28 Jan 22 | r05        | Fremad AmagerFremad Amager | 0 - 0 | RoskildeRoskilde |
| 28 Jan 22 | r05        | Wiener NeustadtWiener Neusta | 2 - 0 | SV HornSV Horn |
| 28 Jan 22 | r05        | Vendsyssel FFVendsyssel FF | 3 - 2 | Aarhus FremadAarhus Fremad |
| 28 Jan 22 | r05        | KøgeKøge | 1 - 2 | HillerødHillerød |
| 28 Jan 22 | r05        | FC HelsingoerFC Helsingoer | 5 - 2 | AB GladsaxeAB Gladsaxe |
| 28 Jan 22 | r05        | BohemiansBohemians | 1 - 0 | Bray WanderersBray Wanderer |
| 29 Jan 22 | r05        | GomelGomel | - | Slavia MozyrSlavia Mozyr |
| 29 Jan 22 | r05        | First ViennaFirst Vienna | - | LíšeňLíšeň |
| 29 Jan 22 | r05        | BełchatówBełchatów | - | Arka GdyniaArka Gdynia |
| 29 Jan 22 | r05        | Kolding IFKolding IF | 2 - 3 | FredericiaFredericia |
| 29 Jan 22 | r05        | Viktoria PlzenViktoria Plze | - | ŠKF SereďŠKF Sereď |
| 29 Jan 22 | r05        | VlašimVlašim | 5 - 2 | Vysočina JihlavaVysočina Jihl |
| 29 Jan 22 | r05        | ZlínZlín | 4 - 0 | FK SenicaFK Senica |
| 29 Jan 22 | r05        | LyngbyLyngby | 3 - 3 | Hvidovre IFHvidovre IF |
| 29 Jan 22 | r05        | AGF AarhusAGF Aarhus | 7 - 0 | EsbjergEsbjerg |
| 29 Jan 22 | r05        | Gornik ZabrzeGornik Zabrze | 1 - 1 | Podbeskidzie Bielsko-BialPodbeskidzie |
| 29 Jan 22 | r05        | FremFrem | 2 - 1 | Hellerup IKHellerup IK |
| 29 Jan 22 | r05        | HOBROHOBRO | 2 - 0 | ThistedThisted |
| 29 Jan 22 | r05        | NykøbingNykøbing | 0 - 1 | Næstved BKNæstved BK |
| 29 Jan 22 | r05        | FC CopenhagenFC Copenhagen | 3 - 0 | FC Flora TallinFC Flora Tall |
| 29 Jan 22 | r05        | VfR GarchingVfR Garching | 0 - 2 | 1860 Rosenheim1860 Rosenhei |
| 29 Jan 22 | r05        | HalmstadHalmstad | 0 - 1 | Varbergs BoIS FCVarbergs BoIS |
| 29 Jan 22 | r05        | Holbæk B&IHolbæk B&I | 1 - 1 | Slagelse B&ISlagelse B&I |
| 29 Jan 22 | r05        | NorrbyNorrby | 1 - 2 | Utsiktens BKUtsiktens BK |
| 29 Jan 22 | r05        | LandskronaLandskrona | 3 - 0 | IFK MalmöIFK Malmö |
| 29 Jan 22 | r05        | Legia WarsawLegia Warsaw | 4 - 0 | Radomiak RadomRadomiak Rado |
| 29 Jan 22 | r05        | MFK RužomberokMFK Ružombero | 1 - 2 | BallkaniBallkani |
| 29 Jan 22 | r05        | Skra CzęstochowaSkra Częstoch | 2 - 1 | Stal Stalowa WolaStal Stalowa |
| 29 Jan 22 | r05        | HonkaHonka | 0 - 1 | Paide LinnameeskondPaide Linname |
| 29 Jan 22 | r05        | PardubicePardubice | 4 - 1 | Dukla PrahaDukla Praha |
| 29 Jan 22 | r05        | Hannover IIHannover II | 2 - 3 | Holstein Kiel IIHolstein Kiel |
| 29 Jan 22 | r05        | Miedz LegnicaMiedz Legnica | 0 - 0 | Lech PoznanLech Poznan |
| 29 Jan 22 | r05        | FC SchweinfurtFC Schweinfur | 1 - 4 | Kickers OffenbachKickers Offen |
| 29 Jan 22 | r05        | SiriusSirius | 1 - 3 | HammarbyHammarby |
| 29 Jan 22 | r05        | Veres RivneVeres Rivne | 3 - 4 | KarvinaKarvina |
| 29 Jan 22 | r05        | Baltika KaliningradBaltika Kalin | 0 - 1 | PFC SochiPFC Sochi |
| 29 Jan 22 | r05        | Alania VladikavkazAlania Vladik | 0 - 0 | CukarickiCukaricki |
| 29 Jan 22 | r05        | SV SalzburgSV Salzburg | - | WSG Swarovski TirolWSG Swarovski |
| 29 Jan 22 | r05        | Waterford FCWaterford FC | 2 - 1 | DundalkDundalk |
| 29 Jan 22 | r05        | FC TobolFC Tobol | 0 - 3 | Bregalnica ŠtipBregalnica Št |
| 29 Jan 22 | r05        | DAC 1904 Dunajská StredaDAC 1904 Duna | 0 - 1 | PFC Kuban KrasnodarPFC Kuban Kra |
| 29 Jan 22 | r05        | FC Trenkwalder AdmiraFC Trenkwalde | 2 - 3 | FC BW LinzFC BW Linz |
| 29 Jan 22 | r05        | Cork City FCCork City FC | 1 - 1 | Finn Harps FCFinn Harps FC |
| 29 Jan 22 | r05        | Levski SofiaLevski Sofia | 2 - 2 | NK MariborNK Maribor |
| 29 Jan 22 | r05        | New England Rev.New England R | 1 - 1 | Los Angeles FCLos Angeles F |
| 29 Jan 22 | r05        | Sporting Kansas CitySporting Kans | 0 - 0 | Colorado RapidsColorado Rapi |
| 30 Jan 22 | r05        | Makedonija GjPMakedonija Gj | 0 - 0 | SC Rheindorf AltachSC Rheindorf |
| 30 Jan 22 | r05        | Metalac GMMetalac GM | 1 - 0 | SileksSileks |
| 30 Jan 22 | r05        | Slavia PragueSlavia Prague | 4 - 2 | Banik OstravaBanik Ostrava |
| 30 Jan 22 | r05        | Slavia SofiaSlavia Sofia | 3 - 2 | NŠ MuraNŠ Mura |
| 30 Jan 22 | r05        | Krylya Sovetov SamaraKrylya Soveto | 0 - 0 | Akademija PandevAkademija Pan |
| 31 Jan 22 | r05        | Shakhter KaragandaShakhter Kara | 1 - 5 | CSKA SofiaCSKA Sofia |
| 31 Jan 22 | r05        | Borac Banja LukaBorac Banja L | - | Shakhter SoligorskShakhter Soli |
| 31 Jan 22 | r05        | LKS LodzLKS Lodz | 1 - 1 | Rudar PljevljaRudar Pljevlj |
| 31 Jan 22 | r05        | Metallurg LipetskMetallurg Lip | 1 - 1 | CsikszeredaCsikszereda |
| 31 Jan 22 | r05        | FC NordsjællandFC Nordsjælla | 3 - 0 | IFK GothenburgIFK Gothenbur |
| 31 Jan 22 | r05        | Terek GroznyTerek Grozny | 2 - 2 | ShkupiShkupi |
| 31 Jan 22 | r05        | DAC 1904 Dunajská StredaDAC 1904 Duna | 0 - 2 | CukarickiCukaricki |
| 31 Jan 22 | r05        | Shakhtar DonetskShakhtar Done | 3 - 2 | Crvena ZvezdaCrvena Zvezda |
| 31 Jan 22 | r05        | FC OlexandriaFC Olexandria | 3 - 0 | Vejle BoldklubVejle Boldklu |
| 01 Feb 22 | r05        | Torpedo MoscowTorpedo Mosco | 4 - 1 | SileksSileks |
| 01 Feb 22 | r05        | Vysočina JihlavaVysočina Jihl | 3 - 3 | ChrudimChrudim |
| 01 Feb 22 | r05        | FC SKA Rostov-on-DonFC SKA Rostov | 0 - 2 | VardarVardar |
| 01 Feb 22 | r05        | Ararat-ArmeniaArarat-Armeni | 2 - 3 | Slovan BratislavaSlovan Bratis |
| 01 Feb 22 | r05        | MFK RužomberokMFK Ružombero | 2 - 1 | Dinamo MoscowDinamo Moscow |
| 01 Feb 22 | r05        | Velez MostarVelez Mostar | 3 - 0 | GOŠK GabelaGOŠK Gabela |
| 02 Feb 22 | r05        | Tychy 71Tychy 71 | 2 - 2 | JastrzębieJastrzębie |
| 02 Feb 22 | r05        | Zaglebie SosnowiecZaglebie Sosn | - | AktobeAktobe |
| 02 Feb 22 | r05        | Slavoj VyšehradSlavoj Vyšehr | 1 - 6 | VarnsdorfVarnsdorf |
| 02 Feb 22 | r05        | FC LieferingFC Liefering | 2 - 1 | Villarreal BVillarreal B |
| 02 Feb 22 | r05        | MariupolMariupol | P - P | Siroki BrijegSiroki Brijeg |
| 02 Feb 22 | r05        | Brabrand IFBrabrand IF | 1 - 2 | Aarhus FremadAarhus Fremad |
| 02 Feb 22 | r05        | RaufossRaufoss | 2 - 2 | SkeidSkeid |
| 03 Feb 22 | r05        | MontanaMontana | - | SileksSileks |
| 03 Feb 22 | r05        | Slavia SofiaSlavia Sofia | - | VojvodinaVojvodina |
| 03 Feb 22 | r05        | HackenHacken | 0 - 0 | FK RostovFK Rostov |