| 08 Jan 20 | r04  | Ba Ria Vung Tau FCBa Ria Vung T | 3 - 1 | Long An FCLong An FC |
| 08 Jan 20 | r04 | Can Tho FCCan Tho FC | 3 - 0 | An Giang FCAn Giang FC |
| 10 Jan 20 | r04 | Can Tho FCCan Tho FC | 2 - 0 | Khanh Hoa FCKhanh Hoa FC |
| 12 Jan 20 | r04 | An Giang FCAn Giang FC | 0 - 3 | Khanh Hoa FCKhanh Hoa FC |
| 14 Jan 20 | r04 | Ba Ria Vung Tau FCBa Ria Vung T | 2 - 1 | Binh Phuoc FCBinh Phuoc FC |
| 16 Jan 20 | r04 | Binh Phuoc FCBinh Phuoc FC | 1 - 1 | Long An FCLong An FC |
| 16 Jan 20 | r04 | Ba Ria Vung Tau FCBa Ria Vung T | 3 - 0 | Pho Hien FCPho Hien FC |
| 16 Jan 20 | r04 | Szombathelyi HaladásSzombathelyi | 1 - 3 | TiszakécskeTiszakécske |
| 25 Jan 20 | r04 | VfL OldenburgVfL Oldenburg | 1 - 4 | Atlas DelmenhorstAtlas Delmenh |
| 22 Feb 20 | r04 | Can Tho FCCan Tho FC | 2 - 1 | An Giang FCAn Giang FC |
| 01 Jul 20 | r04 | SV TECSV TEC | 4 - 2 | Sparta NijkerkSparta Nijker |
| 17 Jul 20 | r04 | HVV HollandiaHVV Hollandia | 3 - 4 | Jong VolendamJong Volendam |
| 18 Jul 20 | r04 | III Kerületi TVEIII Kerületi | 1 - 3 | BudaörsBudaörs |
| 18 Jul 20 | r04 | Spartak VarnaSpartak Varna | P - P | SozopolSozopol |
| 22 Jul 20 | r04 | Lokomotiv Gorna OryahovitLokomotiv Gor | P - P | Spartak VarnaSpartak Varna |
| 24 Jul 20 | r04 | First ViennaFirst Vienna | 6 - 3 | Wiener NeustadtWiener Neusta |
| 25 Jul 20 | r04 | FC LisseFC Lisse | 0 - 3 | Amsterdamsche FCAmsterdamsche |
| 25 Jul 20 | r04 | Sparta NijkerkSparta Nijker | 1 - 2 | VV NoordwijkVV Noordwijk |
| 25 Jul 20 | r04 | VVSBVVSB | 2 - 2 | Rijnsburgse BoysRijnsburgse B |
| 26 Jul 20 | r04 | SzolnokSzolnok | 1 - 1 | Kecskeméti TEKecskeméti TE |
| 01 Aug 20 | r04 | Harkemase BoysHarkemase Boy | 1 - 0 | HHC HardenbergHHC Hardenber |
| 01 Aug 20 | r04 | USV HerculesUSV Hercules | 1 - 0 | De TreffersDe Treffers |
| 01 Aug 20 | r04 | Kozakken BoysKozakken Boys | 3 - 5 | Sparta NijkerkSparta Nijker |
| 04 Aug 20 | r04 | RKVV WestlandiaRKVV Westland | 1 - 3 | SVV ScheveningenSVV Schevenin |
| 04 Aug 20 | r04 | RKVV DEMRKVV DEM | 2 - 2 | Koninklijke HFCKoninklijke H |
| 05 Aug 20 | r04 | PanduriiPandurii | 0 - 4 | FC U Craiova 1948FC U Craiova |
| 08 Aug 20 | r04 | Sparta NijkerkSparta Nijker | 2 - 2 | Amsterdamsche FCAmsterdamsche |
| 08 Aug 20 | r04 | FC LisseFC Lisse | 3 - 7 | Rijnsburgse BoysRijnsburgse B |
| 08 Aug 20 | r04 | Atlas DelmenhorstAtlas Delmenh | 2 - 3 | VfL OldenburgVfL Oldenburg |
| 08 Aug 20 | r04 | Les Herbiers VFLes Herbiers | 2 - 0 | Voltigeurs de ChâteaubriaVoltigeurs de |
| 08 Aug 20 | r04 | De TreffersDe Treffers | P - P | GVV UnitasGVV Unitas |
| 11 Aug 20 | r04 | GVVVGVVV | 2 - 0 | VVOGVVOG |
| 11 Aug 20 | r04 | BVV BarendrechtBVV Barendrec | 1 - 1 | ExcelsiorExcelsior |
| 11 Aug 20 | r04 | IJsselmeervogelsIJsselmeervog | 0 - 1 | USV HerculesUSV Hercules |
| 15 Aug 20 | r04 | Kozakken BoysKozakken Boys | 5 - 1 | VV CapelleVV Capelle |
| 18 Aug 20 | r04 | Rijnsburgse BoysRijnsburgse B | 1 - 0 | HSV ODIN 59HSV ODIN 59 |
| 18 Aug 20 | r04 | GVVVGVVV | 3 - 1 | Blauw Geel 38Blauw Geel 38 |
| 18 Aug 20 | r04 | Quick BoysQuick Boys | 3 - 0 | Ter LeedeTer Leede |
| 22 Aug 20 | r04 | De TreffersDe Treffers | 2 - 0 | VV UNAVV UNA |
| 23 Aug 20 | r04 | VfL OldenburgVfL Oldenburg | 2 - 2 | Bremer SVBremer SV |
| 25 Aug 20 | r04 | BVV BarendrechtBVV Barendrec | 1 - 2 | VV ASWHVV ASWH |
| 25 Aug 20 | r04 | Koninklijke HFCKoninklijke H | 2 - 1 | Ter LeedeTer Leede |
| 25 Aug 20 | r04 | VV DOVOVV DOVO | 3 - 3 | SV SpakenburgSV Spakenburg |
| 25 Aug 20 | r04 | VV NoordwijkVV Noordwijk | 1 - 1 | HVV HollandiaHVV Hollandia |
| 29 Aug 20 | r04 | Kozakken BoysKozakken Boys | 1 - 3 | Jong SpartaJong Sparta |
| 01 Jan 21 | r04 | Khanh Hoa FCKhanh Hoa FC | 2 - 3 | Da NangDa Nang |
| 01 Jan 21 | r04 | Binh DuongBinh Duong | 2 - 1 | Nam DinhNam Dinh |
| 02 Jan 21 | r04 | Ho Chi Minh CityHo Chi Minh C | 2 - 1 | Ha NoiHa Noi |
| 02 Jan 21 | r04 | Sai GonSai Gon | 1 - 1 | Binh DinhBinh Dinh |
| 03 Jan 21 | r04 | Nam DinhNam Dinh | 1 - 1 | Hoang Anh Gia LaiHoang Anh Gia |
| 03 Jan 21 | r04 | Binh DuongBinh Duong | 0 - 0 | Khanh Hoa FCKhanh Hoa FC |
| 05 Jan 21 | r04 | Hoang Anh Gia LaiHoang Anh Gia | 2 - 1 | Khanh Hoa FCKhanh Hoa FC |
| 05 Jan 21 | r04 | Binh DuongBinh Duong | 0 - 0 | Da NangDa Nang |
| 07 Jan 21 | r04 | Sai GonSai Gon | 2 - 2 | Da NangDa Nang |
| 09 Jan 21 | r04 | SoroksárSoroksár | 1 - 0 | DorogDorog |
| 09 Jan 21 | r04 | LaredoLaredo | 1 - 0 | Rayo CantabriaRayo Cantabri |
| 15 Jan 21 | r04 | Litex LovechLitex Lovech | 1 - 0 | Lokomotiv Gorna OryahovitLokomotiv Gor |
| 16 Jan 21 | r04 | SoroksárSoroksár | 0 - 4 | PécsPécs |
| 16 Jan 21 | r04 | Akademija PandevAkademija Pan | 2 - 1 | BorecBorec |
| 19 Jan 21 | r04 | Pirin BlagoevgradPirin Blagoev | 5 - 1 | Marek DupnitsaMarek Dupnits |
| 20 Jan 21 | r04 | SoroksárSoroksár | 1 - 2 | VasasVasas |
| 20 Jan 21 | r04 | SesveteSesvete | 2 - 0 | KustošijaKustošija |
| 20 Jan 21 | r04 | Hebar PazardzhikHebar Pazardz | 3 - 0 | Maritsa PlovdivMaritsa Plovd |
| 20 Jan 21 | r04 | BorecBorec | 1 - 1 | RabotnichkiRabotnichki |
| 20 Jan 21 | r04 | OpatijaOpatija | 2 - 3 | Hrvatski DragovoljacHrvatski Drag |
| 21 Jan 21 | r04 | CSM ReşiţaCSM Reşiţa | 3 - 1 | FC Politehnica TimisoaraFC Politehnic |
| 21 Jan 21 | r04 | BelasicaBelasica | 2 - 3 | TikvešTikveš |
| 21 Jan 21 | r04 | Strumska SlavaStrumska Slav | 1 - 2 | Ludogorets Razgrad IILudogorets Ra |
| 22 Jan 21 | r04 | PetrolulPetrolul | 2 - 1 | Dunarea CalarasiDunarea Calar |
| 23 Jan 21 | r04 | GyirmótGyirmót | 1 - 0 | CsákvárCsákvár |
| 23 Jan 21 | r04 | SesveteSesvete | 3 - 5 | DubravaDubrava |
| 23 Jan 21 | r04 | Litex LovechLitex Lovech | 2 - 0 | Yantra GabrovoYantra Gabrov |
| 23 Jan 21 | r04 | Lokomotiv SofiaLokomotiv Sof | 0 - 0 | Lokomotiv Gorna OryahovitLokomotiv Gor |
| 23 Jan 21 | r04 | RabotnichkiRabotnichki | 2 - 0 | TeteksTeteks |
| 23 Jan 21 | r04 | OpatijaOpatija | 2 - 1 | KustošijaKustošija |
| 23 Jan 21 | r04 | FUS RabatFUS Rabat | 1 - 3 | Chabab MohammédiaChabab Mohamm |
| 24 Jan 21 | r04 | Szombathelyi HaladásSzombathelyi | 1 - 1 | SzolnokSzolnok |
| 26 Jan 21 | r04 | LDU QuitoLDU Quito | 2 - 0 | FenixFenix |
| 26 Jan 21 | r04 | StrugaStruga | 3 - 2 | PelisterPelister |
| 27 Jan 21 | r04 | Rapid BucurestiRapid Bucures | 1 - 0 | Universitatea ClujUniversitatea |
| 27 Jan 21 | r04 | DubravaDubrava | 2 - 0 | Hrvatski DragovoljacHrvatski Drag |
| 27 Jan 21 | r04 | RenovaRenova | 3 - 3 | RabotnichkiRabotnichki |
| 27 Jan 21 | r04 | KolubaraKolubara | 5 - 1 | ŽarkovoŽarkovo |
| 27 Jan 21 | r04 | BorecBorec | 2 - 0 | TeteksTeteks |
| 27 Jan 21 | r04 | OpatijaOpatija | 2 - 3 | SesveteSesvete |
| 28 Jan 21 | r04 | CSA Steaua BucureştiCSA Steaua Bu | 4 - 1 | Universitatea ClujUniversitatea |
| 28 Jan 21 | r04 | PelisterPelister | 2 - 2 | FK Jagodina FK Jagodina |
| 30 Jan 21 | r04 | EmelecEmelec | 0 - 0 | Técnico UniversitarioTécnico Unive |
| 30 Jan 21 | r04 | Ripensia TimisoaraRipensia Timi | - | PanduriiPandurii |
| 30 Jan 21 | r04 | TeteksTeteks | 1 - 3 | FK Jagodina FK Jagodina |
| 30 Jan 21 | r04 | Ludogorets Razgrad IILudogorets Ra | 1 - 1 | Sportist SvogeSportist Svog |
| 30 Jan 21 | r04 | Hajduk Split IIHajduk Split | 3 - 2 | DugopoljeDugopolje |
| 30 Jan 21 | r04 | FC YessentukiFC Yessentuki | 1 - 2 | FC Mashuk-KMV PyatigorskFC Mashuk-KMV |
| 30 Jan 21 | r04 | KustošijaKustošija | 3 - 0 | Hrvatski DragovoljacHrvatski Drag |
| 30 Jan 21 | r04 | StrugaStruga | 0 - 0 | RabotnichkiRabotnichki |
| 30 Jan 21 | r04 | Lokomotiv SofiaLokomotiv Sof | - | Strumska SlavaStrumska Slav |
| 30 Jan 21 | r04 | BelasicaBelasica | 0 - 0 | Radnički Sremska MitrovicRadnički Srem |
| 30 Jan 21 | r04 | Avangard KurskAvangard Kurs | - | FC Chernomorets NovorossiFC Chernomore |
| 30 Jan 21 | r04 | DubravaDubrava | 5 - 1 | OpatijaOpatija |
| 30 Jan 21 | r04 | VMFD ZalgirisVMFD Zalgiris | 4 - 2 | NevėžisNevėžis |
| 31 Jan 21 | r04 | Hrvatski DragovoljacHrvatski Drag | 2 - 0 | SesveteSesvete |
| 31 Jan 21 | r04 | FC Druzhba MaykopFC Druzhba Ma | 0 - 5 | FC SKA Rostov-on-DonFC SKA Rostov |
| 31 Jan 21 | r04 | DubravaDubrava | 1 - 3 | KustošijaKustošija |
| 01 Feb 21 | r04 | MantaManta | 2 - 4 | Barcelona SCBarcelona SC |
| 01 Feb 21 | r04 | PeñarolPeñarol | - | BelgranoBelgrano |
| 01 Feb 21 | r04 | Adelaide Olympic FCAdelaide Olym | - | Adelaide Comets FCAdelaide Come |
| 01 Feb 21 | r04 | Mt Druitt Town Rangers FCMt Druitt Tow | - | Blacktown City FCBlacktown Cit |
| 01 Feb 21 | r04 | Queensland Lions FCQueensland Li | - | Sunshine Coast FCSunshine Coas |
| 01 Feb 21 | r04 | StrugaStruga | 3 - 1 | TeteksTeteks |
| 03 Feb 21 | r04 | RabotnichkiRabotnichki | 1 - 1 | PelisterPelister |
| 03 Feb 21 | r04 | Litex LovechLitex Lovech | 0 - 0 | Septemvri SofiaSeptemvri Sof |
| 03 Feb 21 | r04 | KolubaraKolubara | 3 - 0 | Radnički 1923Radnički 1923 |
| 04 Feb 21 | r04 | Merani MartviliMerani Martvi | 5 - 2 | Dinamo ZugdidiDinamo Zugdid |
| 04 Feb 21 | r04 | Ripensia TimisoaraRipensia Timi | 1 - 2 | CSM ReşiţaCSM Reşiţa |
| 05 Feb 21 | r04 | Guayaquil City FCGuayaquil Cit | 0 - 1 | Barcelona SCBarcelona SC |
| 05 Feb 21 | r04 | Dunarea CalarasiDunarea Calar | 2 - 2 | Rapid BucurestiRapid Bucures |
| 05 Feb 21 | r04 | Spartak VarnaSpartak Varna | 1 - 2 | Strumska SlavaStrumska Slav |
| 06 Feb 21 | r04 | FK Suduva FK Suduva | 1 - 1 | Hegelmann LitauenHegelmann Lit |
| 06 Feb 21 | r04 | FC U Craiova 1948FC U Craiova | 2 - 1 | CSM ReşiţaCSM Reşiţa |
| 06 Feb 21 | r04 | Borac CacakBorac Cacak | 1 - 0 | FK ZemunFK Zemun |
| 06 Feb 21 | r04 | BelasicaBelasica | 1 - 1 | Bregalnica ŠtipBregalnica Št |
| 06 Feb 21 | r04 | RabotnichkiRabotnichki | 1 - 1 | TikvešTikveš |
| 06 Feb 21 | r04 | VMFD ZalgirisVMFD Zalgiris | - | FK RiteriaiFK Riteriai |
| 08 Feb 21 | r04 | FK SarajevoFK Sarajevo | 1 - 0 | Triglav KranjTriglav Kranj |
| 10 Feb 21 | r04 | FC YessentukiFC Yessentuki | 1 - 3 | PFC Spartak NalchikPFC Spartak N |
| 10 Feb 21 | r04 | FC Dnepr MogilevFC Dnepr Mogi | 6 - 0 | FC OrshaFC Orsha |
| 10 Feb 21 | r04 | FC Chernomorets NovorossiFC Chernomore | 4 - 3 | FC Volga UlyanovskFC Volga Ulya |
| 10 Feb 21 | r04 | PanduriiPandurii | 1 - 1 | SlatinaSlatina |
| 10 Feb 21 | r04 | FC Mashuk-KMV PyatigorskFC Mashuk-KMV | 0 - 1 | Anzhi MakhachkalaAnzhi Makhach |
| 10 Feb 21 | r04 | Radnički 1923Radnički 1923 | 3 - 0 | OFK BeogradOFK Beograd |
| 13 Feb 21 | r04 | ConcordiaConcordia | 1 - 0 | MetaloglobusMetaloglobus |
| 13 Feb 21 | r04 | FC YessentukiFC Yessentuki | 0 - 4 | FC Legion Dynamo MakhachkFC Legion Dyn |
| 13 Feb 21 | r04 | CS MioveniCS Mioveni | 1 - 2 | Rapid BucurestiRapid Bucures |
| 13 Feb 21 | r04 | FK Suduva FK Suduva | 1 - 1 | Banga GargždaiBanga Gargžda |
| 13 Feb 21 | r04 | PanduriiPandurii | - | FC U Craiova 1948FC U Craiova |
| 13 Feb 21 | r04 | VMFD ZalgirisVMFD Zalgiris | 3 - 0 | FK RiteriaiFK Riteriai |
| 13 Feb 21 | r04 | TrezeTreze | 1 - 2 | GloboGlobo |
| 14 Feb 21 | r04 | FC Chernomorets NovorossiFC Chernomore | - | FC Sokol SaratovFC Sokol Sara |
| 14 Feb 21 | r04 | FC Kuban-Holding PavlovskFC Kuban-Hold | 1 - 0 | FC KalugaFC Kaluga |
| 15 Feb 21 | r04 | Barcelona SCBarcelona SC | 1 - 1 | 9 de Octubre9 de Octubre |
| 16 Feb 21 | r04 | PFC Spartak NalchikPFC Spartak N | 2 - 5 | FC Legion Dynamo MakhachkFC Legion Dyn |
| 17 Feb 21 | r04 | FC Zenit-IzhevskFC Zenit-Izhe | 1 - 2 | FC Zvezda PermFC Zvezda Per |
| 18 Feb 21 | r04 | TeteksTeteks | 4 - 0 | Bregalnica ŠtipBregalnica Št |
| 18 Feb 21 | r04 | Locomotive TbilisiLocomotive Tb | 1 - 4 | LinenseLinense |
| 18 Feb 21 | r04 | TrezeTreze | 1 - 3 | America RNAmerica RN |
| 20 Feb 21 | r04 | FC YessentukiFC Yessentuki | 4 - 2 | FC TuapseFC Tuapse |
| 20 Feb 21 | r04 | FC RyazanFC Ryazan | 3 - 1 | FC Kvant ObninskFC Kvant Obni |
| 20 Feb 21 | r04 | MjoendalenMjoendalen | - | SandefjordSandefjord |
| 23 Feb 21 | r04 | FC Mashuk-KMV PyatigorskFC Mashuk-KMV | 2 - 0 | FC TuapseFC Tuapse |
| 24 Feb 21 | r04 | FC Kuban-Holding PavlovskFC Kuban-Hold | - | KAMAZ Naberezhnye ChelnyKAMAZ Naberez |
| 24 Feb 21 | r04 | FC RyazanFC Ryazan | - | FC Metallurg VidnoyeFC Metallurg |
| 25 Feb 21 | r04 | FC NovosibirskFC Novosibirs | 2 - 4 | FC Chernomorets NovorossiFC Chernomore |
| 25 Feb 21 | r04 | FC Zvezda PermFC Zvezda Per | 0 - 3 | FC Zenit-IzhevskFC Zenit-Izhe |
| 25 Feb 21 | r04 | FC YessentukiFC Yessentuki | 1 - 4 | FC Salyut BelgorodFC Salyut Bel |
| 25 Feb 21 | r04 | Puerto Cabello F.C.Puerto Cabell | 1 - 2 | Hermanos ColmenarezHermanos Colm |
| 26 Feb 21 | r04 | FC YessentukiFC Yessentuki | 4 - 2 | FC TuapseFC Tuapse |
| 26 Feb 21 | r04 | ExtremaduraExtremadura | 2 - 2 | Salamanca UDSSalamanca UDS |
| 26 Feb 21 | r04 | Universidad CentralUniversidad C | 1 - 1 | Puerto Cabello F.C.Puerto Cabell |
| 26 Feb 21 | r04 | Deportivo LaraDeportivo Lar | 1 - 0 | Portuguesa F.C.Portuguesa F. |
| 27 Feb 21 | r04 | FC Sokol SaratovFC Sokol Sara | 1 - 2 | PFC Kuban KrasnodarPFC Kuban Kra |
| 27 Feb 21 | r04 | FC Sokol SaratovFC Sokol Sara | - | FC Kuban-Holding PavlovskFC Kuban-Hold |
| 27 Feb 21 | r04 | Deportivo LaraDeportivo Lar | 1 - 1 | Puerto Cabello F.C.Puerto Cabell |
| 28 Feb 21 | r04 | FK Suduva FK Suduva | 1 - 0 | NevėžisNevėžis |
| 28 Feb 21 | r04 | FC Kuban-Holding PavlovskFC Kuban-Hold | 2 - 2 | FC NovosibirskFC Novosibirs |
| 28 Feb 21 | r04 | Deportivo LaraDeportivo Lar | 2 - 2 | Hermanos ColmenarezHermanos Colm |
| 28 Feb 21 | r04 | Portuguesa F.C.Portuguesa F. | 1 - 0 | Universidad CentralUniversidad C |
| 01 Mar 21 | r04 | FC YessentukiFC Yessentuki | 1 - 3 | FC Mashuk-KMV PyatigorskFC Mashuk-KMV |
| 01 Mar 21 | r04 | PFC Spartak NalchikPFC Spartak N | 1 - 0 | FC Salyut BelgorodFC Salyut Bel |
| 03 Mar 21 | r04 | FC Kuban-Holding PavlovskFC Kuban-Hold | 1 - 1 | FC Luki-Energiya VelikiyeFC Luki-Energ |
| 05 Mar 21 | r04 | FC NovosibirskFC Novosibirs | 4 - 1 | FC KalugaFC Kaluga |
| 08 Mar 21 | r04 | FC NovosibirskFC Novosibirs | 3 - 1 | Avangard KurskAvangard Kurs |
| 09 Mar 21 | r04 | FC KalugaFC Kaluga | 0 - 1 | FC Luki-Energiya VelikiyeFC Luki-Energ |
| 12 Mar 21 | r04 | FC YessentukiFC Yessentuki | - | FC Salyut BelgorodFC Salyut Bel |
| 20 Mar 21 | r04 | FUS RabatFUS Rabat | 1 - 0 | IR TangerIR Tanger |
| 20 Mar 21 | r04 | CampinenseCampinense | 1 - 0 | Central Sport ClubCentral Sport |
| 21 Mar 21 | r04 | Saturn RamenskoyeSaturn Ramens | 0 - 1 | FC Zvezda PermFC Zvezda Per |
| 22 Mar 21 | r04 | Saturn RamenskoyeSaturn Ramens | 0 - 3 | FC RyazanFC Ryazan |
| 23 Mar 21 | r04 | Torns IFTorns IF | 4 - 0 | IFK MalmöIFK Malmö |
| 24 Mar 21 | r04 | Central Sport ClubCentral Sport | - | CampinenseCampinense |
| 27 Mar 21 | r04 | AlcoyanoAlcoyano | 2 - 2 | EldenseEldense |
| 27 Mar 21 | r04 | FC NovosibirskFC Novosibirs | 3 - 1 | FC Nosta NovotroitskFC Nosta Novo |
| 22 May 21 | r04 | Basford Utd.Basford Utd. | 3 - 0 | Mickleover SportsMickleover Sp |
| 28 May 21 | r04 | Worksop TownWorksop Town | 5 - 0 | Mickleover SportsMickleover Sp |
| 05 Jun 21 | r04 | Cumbernauld ColtsCumbernauld C | 2 - 2 | Musselburgh Athletic F.C.Musselburgh A |
| 12 Jun 21 | r04 | The SpartansThe Spartans | 2 - 2 | Lothian Thistle HutchisonLothian Thist |
| 14 Jun 21 | r04 | BirkirkaraBirkirkara | 3 - 1 | Hibernians FCHibernians FC |
| 19 Jun 21 | r04 | PortstewartPortstewart | 0 - 2 | ColeraineColeraine |
| 22 Jun 21 | r04 | Gżira UnitedGżira United | 3 - 0 | Hibernians FCHibernians FC |
| 23 Jun 21 | r04 | Metalac GMMetalac GM | 1 - 0 | DečićDečić |
| 24 Jun 21 | r04 | StrugaStruga | 1 - 1 | PartizaniPartizani |
| 24 Jun 21 | r04 | SileksSileks | 0 - 1 | KS Teuta KS Teuta |
| 25 Jun 21 | r04 | Shkendija 79Shkendija 79 | 2 - 1 | LaciLaci |
| 26 Jun 21 | r04 | Gżira UnitedGżira United | 3 - 0 | BirkirkaraBirkirkara |
| 27 Jun 21 | r04 | MarienlystMarienlyst | - | B 1909B 1909 |
| 28 Jun 21 | r04 | Mosta FCMosta FC | 0 - 1 | Hibernians FCHibernians FC |
| 30 Jun 21 | r04 | CSKA 1948 IICSKA 1948 II | 0 - 2 | Maritsa PlovdivMaritsa Plovd |
| 30 Jun 21 | r04 | Gżira UnitedGżira United | 2 - 1 | Ħamrun SpartansĦamrun Sparta |
| 30 Jun 21 | r04 | Rudar PljevljaRudar Pljevlj | 0 - 2 | SlobodaSloboda |
| 01 Jul 21 | r04 | BirkirkaraBirkirkara | 2 - 1 | Mosta FCMosta FC |
| 01 Jul 21 | r04 | Stafford RangersStafford Rang | 2 - 1 | TNSTNS |
| 03 Jul 21 | r04 | Botev Plovdiv IIBotev Plovdiv | 1 - 2 | Maritsa PlovdivMaritsa Plovd |
| 03 Jul 21 | r04 | The SpartansThe Spartans | 1 - 5 | StenhousemuirStenhousemuir |
| 03 Jul 21 | r04 | Staines TownStaines Town | 1 - 1 | FarnboroughFarnborough |
| 03 Jul 21 | r04 | Limavady UnitedLimavady Unit | 4 - 2 | Ballinamallard UnitedBallinamallar |
| 03 Jul 21 | r04 | Folkestone InvictaFolkestone In | 3 - 1 | Welling UnitedWelling Unite |
| 03 Jul 21 | r04 | Dorking WanderersDorking Wande | 1 - 0 | KingstonianKingstonian |
| 03 Jul 21 | r04 | Carshalton AthleticCarshalton At | 3 - 1 | Walton CasualsWalton Casual |
| 03 Jul 21 | r04 | FC RyazanFC Ryazan | 7 - 2 | FC Znamya Truda Orekhovo-FC Znamya Tru |
| 03 Jul 21 | r04 | SozopolSozopol | 1 - 2 | Spartak VarnaSpartak Varna |
| 03 Jul 21 | r04 | BorecBorec | 0 - 2 | Bregalnica ŠtipBregalnica Št |
| 03 Jul 21 | r04 | ACS SirineasaACS Sirineasa | 0 - 2 | SlatinaSlatina |
| 04 Jul 21 | r04 | FC Torpedo VladimirFC Torpedo Vl | 2 - 3 | FC Khimik DzerzhinskFC Khimik Dze |
| 04 Jul 21 | r04 | FC Zenit PenzaFC Zenit Penz | - | FC Sokol SaratovFC Sokol Sara |
| 05 Jul 21 | r04 | GraysGrays | 2 - 3 | Cray Valley PMCray Valley P |
| 06 Jul 21 | r04 | FC Zenit-IzhevskFC Zenit-Izhe | 0 - 2 | FC ChelyabinskFC Chelyabins |
| 06 Jul 21 | r04 | Broxburn Athletic F.C.Broxburn Athl | 2 - 1 | East StirlingshireEast Stirling |
| 06 Jul 21 | r04 | WittonWitton | 1 - 3 | Macclesfield TownMacclesfield |
| 07 Jul 21 | r04 | PécsPécs | 3 - 0 | Szeged-CsanádSzeged-Csanád |
| 07 Jul 21 | r04 | CSA Steaua BucureştiCSA Steaua Bu | 6 - 0 | OFK BeogradOFK Beograd |
| 07 Jul 21 | r04 | TikvešTikveš | 3 - 1 | RabotnichkiRabotnichki |
| 08 Jul 21 | r04 | VV KatwijkVV Katwijk | 3 - 2 | FC RijnvogelsFC Rijnvogels |
| 09 Jul 21 | r04 | FC Khimik DzerzhinskFC Khimik Dze | 1 - 2 | FC Torpedo VladimirFC Torpedo Vl |
| 09 Jul 21 | r04 | FC YessentukiFC Yessentuki | 1 - 2 | FC Biolog-NovokubanskFC Biolog-Nov |
| 09 Jul 21 | r04 | FC Zenit-IzhevskFC Zenit-Izhe | 2 - 0 | FK Spartak TuymazyFK Spartak Tu |
| 09 Jul 21 | r04 | MatlockMatlock | 3 - 2 | Boston United FCBoston United |
| 10 Jul 21 | r04 | III Kerületi TVEIII Kerületi | 3 - 3 | BudaörsBudaörs |
| 10 Jul 21 | r04 | Kaposvári Rákóczi FCKaposvári Rák | - | PécsPécs |
| 10 Jul 21 | r04 | Marske UnitedMarske United | - | Blyth SpartansBlyth Spartan |
| 10 Jul 21 | r04 | Ballyclare ComradesBallyclare Co | 2 - 0 | Limavady UnitedLimavady Unit |
| 10 Jul 21 | r04 | PortstewartPortstewart | 1 - 3 | KnockbredaKnockbreda |
| 10 Jul 21 | r04 | Linlithgow Rose F.C.Linlithgow Ro | 1 - 0 | Bo'ness UnitedBo'ness Unite |
| 10 Jul 21 | r04 | Haringey BoroughHaringey Boro | 1 - 3 | ChelmsfordChelmsford |
| 10 Jul 21 | r04 | Folkestone InvictaFolkestone In | 3 - 3 | Eastbourne BoroughEastbourne Bo |
| 10 Jul 21 | r04 | Didcot TownDidcot Town | 0 - 4 | Hungerford TownHungerford To |
| 10 Jul 21 | r04 | Braintree TownBraintree Tow | 0 - 1 | Bishops StortfordBishops Stort |
| 10 Jul 21 | r04 | Wimborne TownWimborne Town | 4 - 0 | ChristchurchChristchurch |
| 10 Jul 21 | r04 | Hebar PazardzhikHebar Pazardz | 4 - 0 | Botev Plovdiv IIBotev Plovdiv |
| 10 Jul 21 | r04 | Sirens FCSirens FC | 0 - 1 | Balzan FCBalzan FC |
| 10 Jul 21 | r04 | Akademija PandevAkademija Pan | 2 - 0 | RabotnichkiRabotnichki |
| 10 Jul 21 | r04 | ŠibenikŠibenik | 0 - 2 | PosušjePosušje |
| 10 Jul 21 | r04 | SlobodaSloboda | 1 - 1 | Sloga DobojSloga Doboj |
| 10 Jul 21 | r04 | Javor IvanjicaJavor Ivanjic | 1 - 0 | Zlatibor ČajetinaZlatibor Čaje |
| 10 Jul 21 | r04 | ZrinjskiZrinjski | 1 - 0 | GOŠK GabelaGOŠK Gabela |
| 11 Jul 21 | r04 | ClitheroeClitheroe | 0 - 1 | Chester CityChester City |
| 11 Jul 21 | r04 | MornarMornar | 0 - 2 | Bregalnica ŠtipBregalnica Št |
| 13 Jul 21 | r04 | VV KatwijkVV Katwijk | 3 - 4 | Jong VolendamJong Volendam |
| 13 Jul 21 | r04 | Bamber BridgeBamber Bridge | 1 - 1 | ChorleyChorley |
| 13 Jul 21 | r04 | Nantwich TownNantwich Town | 3 - 1 | Stafford RangersStafford Rang |
| 13 Jul 21 | r04 | Skelmersdale UnitedSkelmersdale | - | RadcliffeRadcliffe |
| 14 Jul 21 | r04 | FC Politehnica TimisoaraFC Politehnic | 2 - 0 | CSM ReşiţaCSM Reşiţa |
| 14 Jul 21 | r04 | InđijaInđija | 0 - 1 | MornarMornar |
| 14 Jul 21 | r04 | GyorGyor | 0 - 3 | VasasVasas |
| 14 Jul 21 | r04 | Etar Veliko TarnovoEtar Veliko T | 1 - 0 | Spartak VarnaSpartak Varna |
| 14 Jul 21 | r04 | SkopjeSkopje | 2 - 0 | Akademija PandevAkademija Pan |
| 14 Jul 21 | r04 | GrafičarGrafičar | 2 - 2 | Bregalnica ŠtipBregalnica Št |
| 14 Jul 21 | r04 | DiosgyorDiosgyor | 2 - 0 | KosiceKosice |
| 14 Jul 21 | r04 | NK Inter ZaprešićNK Inter Zapr | 2 - 0 | SesveteSesvete |
| 17 Jul 21 | r04 | SCM Gloria BuzăuSCM Gloria Bu | 1 - 0 | PetrolulPetrolul |
| 17 Jul 21 | r04 | DeveronvaleDeveronvale | 4 - 5 | RothesRothes |
| 17 Jul 21 | r04 | Dorchester TownDorchester To | 5 - 0 | ChristchurchChristchurch |
| 17 Jul 21 | r04 | Spartak VarnaSpartak Varna | 0 - 4 | Dunav RuseDunav Ruse |
| 17 Jul 21 | r04 | Sirens FCSirens FC | - | Gudja UnitedGudja United |
| 17 Jul 21 | r04 | Javor IvanjicaJavor Ivanjic | 1 - 0 | Mačva ŠabacMačva Šabac |
| 17 Jul 21 | r04 | NK VaraždinNK Varaždin | 3 - 2 | NK Inter ZaprešićNK Inter Zapr |
| 17 Jul 21 | r04 | Radnički Sremska MitrovicRadnički Srem | 0 - 2 | Al-FaisalyAl-Faisaly |
| 18 Jul 21 | r04 | Rudar VelenjeRudar Velenje | 1 - 0 | NyíregyházaNyíregyháza |
| 20 Jul 21 | r04 | InđijaInđija | 2 - 0 | BorecBorec |
| 20 Jul 21 | r04 | SalisburySalisbury | - | Havant & WaterloovilleHavant & Wate |
| 21 Jul 21 | r04 | GrafičarGrafičar | 0 - 0 | Radnički Sremska MitrovicRadnički Srem |
| 21 Jul 21 | r04 | SkopjeSkopje | 3 - 2 | TeteksTeteks |
| 21 Jul 21 | r04 | Orijent 1919Orijent 1919 | 3 - 0 | NK Inter ZaprešićNK Inter Zapr |
| 21 Jul 21 | r04 | Mosta FCMosta FC | 1 - 8 | Balzan FCBalzan FC |
| 21 Jul 21 | r04 | Sevenoaks TownSevenoaks Tow | 2 - 4 | LewesLewes |
| 23 Jul 21 | r04 | Szombathelyi HaladásSzombathelyi | 1 - 1 | Al-EttifaqAl-Ettifaq |
| 24 Jul 21 | r04 | RadcliffeRadcliffe | 1 - 2 | Chester CityChester City |
| 25 Jul 21 | r04 | Bačka PalankaBačka Palanka | 0 - 2 | Zlatibor ČajetinaZlatibor Čaje |
| 27 Jul 21 | r04 | OpatijaOpatija | 2 - 3 | Orijent 1919Orijent 1919 |
| 28 Jul 21 | r04 | Al ShababAl Shabab | - | LinenseLinense |
| 28 Jul 21 | r04 | SD LogroñésSD Logroñés | 0 - 0 | Osasuna BOsasuna B |
| 28 Jul 21 | r04 | Sevenoaks TownSevenoaks Tow | 1 - 0 | Tonbridge AngelsTonbridge Ang |
| 28 Jul 21 | r04 | CayónCayón | 0 - 3 | SantanderSantander |
| 28 Jul 21 | r04 | Xerez DeportivoXerez Deporti | 2 - 1 | Real Madrid BReal Madrid B |
| 28 Jul 21 | r04 | Slagelse B&ISlagelse B&I | - | Holbæk B&IHolbæk B&I |
| 29 Jul 21 | r04 | FC AndorraFC Andorra | 2 - 0 | Villarreal BVillarreal B |
| 29 Jul 21 | r04 | Al ShababAl Shabab | 3 - 2 | Algeciras CFAlgeciras CF |
| 31 Jul 21 | r04 | Atlético SanluqueñoAtlético Sanl | 0 - 1 | Xerez DeportivoXerez Deporti |
| 31 Jul 21 | r04 | Valladolid PromesasValladolid Pr | 2 - 1 | Cristo AtléticoCristo Atléti |
| 31 Jul 21 | r04 | CayónCayón | - | Rayo CantabriaRayo Cantabri |
| 01 Aug 21 | r04 | PergolettesePergolettese | 3 - 2 | PiacenzaPiacenza |
| 03 Aug 21 | r04 | Lorca DeportivaLorca Deporti | 2 - 1 | Mar MenorMar Menor |
| 03 Aug 21 | r04 | Sportlust 46Sportlust 46 | 3 - 1 | Excelsior MaassluisExcelsior Maa |
| 04 Aug 21 | r04 | SabadellSabadell | 2 - 1 | CE EuropaCE Europa |
| 04 Aug 21 | r04 | ÁguilasÁguilas | 0 - 0 | Linares DeportivoLinares Depor |
| 04 Aug 21 | r04 | AlcoyanoAlcoyano | 3 - 0 | EldenseEldense |
| 04 Aug 21 | r04 | TropezónTropezón | 1 - 2 | BarakaldoBarakaldo |
| 04 Aug 21 | r04 | AlbaceteAlbacete | 0 - 1 | CF IntercityCF Intercity |
| 05 Aug 21 | r04 | Real Oviedo BReal Oviedo B | 0 - 1 | CD ToledoCD Toledo |
| 05 Aug 21 | r04 | ArosaArosa | 0 - 1 | Racing Club de FerrolRacing Club d |
| 06 Aug 21 | r04 | L-'HospitaletL-'Hospitalet | 0 - 2 | FC AndorraFC Andorra |
| 06 Aug 21 | r04 | Xerez DeportivoXerez Deporti | 1 - 1 | Sevilla AtleticoSevilla Atlet |
| 07 Aug 21 | r04 | Gimnástica Segoviana CFGimnástica Se | 4 - 1 | ZamoraZamora |
| 07 Aug 21 | r04 | Farsley CelticFarsley Celti | - | Hyde UnitedHyde United |
| 07 Aug 21 | r04 | OnisilosOnisilos | 1 - 5 | Nea Salamis FamagustaNea Salamis F |
| 07 Aug 21 | r04 | DubravaDubrava | 3 - 0 | OpatijaOpatija |
| 07 Aug 21 | r04 | LangreoLangreo | 1 - 1 | LeonesaLeonesa |
| 07 Aug 21 | r04 | AlbaceteAlbacete | 1 - 1 | TalaveraTalavera |
| 07 Aug 21 | r04 | Real TitánicoReal Titánico | 1 - 2 | UD LlaneraUD Llanera |
| 07 Aug 21 | r04 | RecreativoRecreativo | 1 - 0 | CordobaCordoba |
| 07 Aug 21 | r04 | CD TeruelCD Teruel | 1 - 1 | CastellónCastellón |
| 07 Aug 21 | r04 | CacereñoCacereño | 2 - 1 | GuijueloGuijuelo |
| 07 Aug 21 | r04 | Atlético SanluqueñoAtlético Sanl | - | ExtremaduraExtremadura |
| 07 Aug 21 | r04 | Espanyol BEspanyol B | 1 - 4 | FC AndorraFC Andorra |
| 07 Aug 21 | r04 | XerezXerez | 0 - 0 | San Fernando CDSan Fernando |
| 07 Aug 21 | r04 | União de LeiriaUnião de Leir | 1 - 1 | Braga BBraga B |
| 07 Aug 21 | r04 | UCAM MurciaUCAM Murcia | 5 - 0 | Mar MenorMar Menor |
| 07 Aug 21 | r04 | Rayo CantabriaRayo Cantabri | 0 - 0 | BarakaldoBarakaldo |
| 07 Aug 21 | r04 | Real Oviedo BReal Oviedo B | 1 - 1 | Real AvilésReal Avilés |
| 07 Aug 21 | r04 | Burgos PromesasBurgos Promes | 1 - 1 | Cristo AtléticoCristo Atléti |
| 07 Aug 21 | r04 | ArenteiroArenteiro | 3 - 0 | Celta Vigo BCelta Vigo B |
| 07 Aug 21 | r04 | Excelsior MaassluisExcelsior Maa | 4 - 0 | RKVV WestlandiaRKVV Westland |
| 07 Aug 21 | r04 | Needham MarketNeedham Marke | - | AFC SudburyAFC Sudbury |
| 08 Aug 21 | r04 | PontevedraPontevedra | 1 - 3 | Racing Club de FerrolRacing Club d |
| 08 Aug 21 | r04 | LinenseLinense | 1 - 1 | Atlético BalearesAtlético Bale |
| 10 Aug 21 | r04 | VV KatwijkVV Katwijk | 2 - 0 | Sparta NijkerkSparta Nijker |
| 10 Aug 21 | r04 | GVVVGVVV | 2 - 3 | SV OSS 20SV OSS 20 |
| 10 Aug 21 | r04 | VV StaphorstVV Staphorst | 1 - 3 | HHC HardenbergHHC Hardenber |
| 10 Aug 21 | r04 | Real CalepinaReal Calepina | 1 - 1 | AlbinoleffeAlbinoleffe |
| 10 Aug 21 | r04 | Al-ArabiAl-Arabi | 3 - 2 | AD Ceuta FCAD Ceuta FC |
| 11 Aug 21 | r04 | EntellaEntella | - | SC Ligorna 1922SC Ligorna 19 |
| 11 Aug 21 | r04 | S.C. Caronnese S.S.D.S.C. Caronnes | 1 - 2 | Pro PatriaPro Patria |
| 11 Aug 21 | r04 | Rayo CantabriaRayo Cantabri | 0 - 1 | BasconiaBasconia |
| 11 Aug 21 | r04 | Real UniónReal Unión | 0 - 2 | Athletic Bilbao BAthletic Bilb |
| 11 Aug 21 | r04 | Real TitánicoReal Titánico | 1 - 2 | LangreoLangreo |
| 11 Aug 21 | r04 | AlbaceteAlbacete | 1 - 1 | UCAM MurciaUCAM Murcia |
| 11 Aug 21 | r04 | Cristo AtléticoCristo Atléti | 0 - 4 | SantanderSantander |
| 11 Aug 21 | r04 | AlcoyanoAlcoyano | 2 - 1 | CF IntercityCF Intercity |
| 11 Aug 21 | r04 | Valladolid PromesasValladolid Pr | 2 - 2 | Burgos PromesasBurgos Promes |
| 11 Aug 21 | r04 | ArenteiroArenteiro | 1 - 1 | CoruxoCoruxo |
| 11 Aug 21 | r04 | Algeciras CFAlgeciras CF | 0 - 1 | CordobaCordoba |
| 11 Aug 21 | r04 | MarinoMarino | 0 - 0 | Real Oviedo BReal Oviedo B |
| 11 Aug 21 | r04 | VillarrubiaVillarrubia | 2 - 0 | Calvo SoteloCalvo Sotelo |
| 12 Aug 21 | r04 | Don BenitoDon Benito | - | ExtremaduraExtremadura |
| 12 Aug 21 | r04 | Valladolid PromesasValladolid Pr | 2 - 2 | Sp Gijon BSp Gijon B |
| 13 Aug 21 | r04 | TeramoTeramo | 2 - 1 | Castelnuovo VomanoCastelnuovo V |
| 13 Aug 21 | r04 | PergolettesePergolettese | 1 - 5 | FeralpisalòFeralpisalò |
| 13 Aug 21 | r04 | AlbinoleffeAlbinoleffe | 0 - 1 | TriestinaTriestina |
| 13 Aug 21 | r04 | Ayia NapaAyia Napa | 0 - 5 | Nea Salamis FamagustaNea Salamis F |
| 13 Aug 21 | r04 | CesenaCesena | 1 - 2 | MantovaMantova |
| 13 Aug 21 | r04 | ZamoraZamora | 2 - 1 | Salamanca UDSSalamanca UDS |
| 13 Aug 21 | r04 | BadajozBadajoz | 1 - 1 | Sevilla AtleticoSevilla Atlet |
| 13 Aug 21 | r04 | CordobaCordoba | 3 - 2 | Rayo MajadahondaRayo Majadaho |
| 14 Aug 21 | r04 | PontevedraPontevedra | - | CoruxoCoruxo |
| 14 Aug 21 | r04 | Mérida ADMérida AD | - | ExtremaduraExtremadura |
| 14 Aug 21 | r04 | Gimnástica de TorrelavegaGimnástica de | 1 - 0 | LaredoLaredo |
| 14 Aug 21 | r04 | Mérida ADMérida AD | 0 - 0 | CD CoriaCD Coria |
| 14 Aug 21 | r04 | UCAM MurciaUCAM Murcia | 2 - 2 | HerculesHercules |
| 14 Aug 21 | r04 | UD LlaneraUD Llanera | 1 - 4 | Sp Gijon BSp Gijon B |
| 14 Aug 21 | r04 | NumanciaNumancia | 5 - 0 | MutilveraMutilvera |
| 14 Aug 21 | r04 | Enosis Neon ParalimniEnosis Neon P | 1 - 1 | Anagennisi DeryneiaAnagennisi De |
| 14 Aug 21 | r04 | Athletic Bilbao BAthletic Bilb | 2 - 1 | SantanderSantander |
| 14 Aug 21 | r04 | EntellaEntella | - | U.S.D. Real Forte dei MarU.S.D. Real F |
| 14 Aug 21 | r04 | LinenseLinense | 2 - 1 | El EjidoEl Ejido |
| 14 Aug 21 | r04 | Gimnástica Segoviana CFGimnástica Se | 1 - 2 | Unionistas de SalamancaUnionistas de |
| 14 Aug 21 | r04 | CF BadalonaCF Badalona | 2 - 0 | CornellàCornellà |
| 14 Aug 21 | r04 | CE EuropaCE Europa | 1 - 2 | Espanyol BEspanyol B |
| 14 Aug 21 | r04 | CD TeruelCD Teruel | 1 - 1 | Valencia MestallaValencia Mest |
| 14 Aug 21 | r04 | L-'HospitaletL-'Hospitalet | 1 - 1 | AE PratAE Prat |
| 14 Aug 21 | r04 | Calvo SoteloCalvo Sotelo | 0 - 0 | CD MarchamaloCD Marchamalo |
| 14 Aug 21 | r04 | AlbaceteAlbacete | 1 - 0 | CastellónCastellón |
| 15 Aug 21 | r04 | San Roque LepeSan Roque Lep | 1 - 1 | RecreativoRecreativo |
| 15 Aug 21 | r04 | Móstoles CFMóstoles CF | 0 - 0 | Mar MenorMar Menor |
| 15 Aug 21 | r04 | ÁguilasÁguilas | 0 - 0 | Lorca DeportivaLorca Deporti |
| 15 Aug 21 | r04 | VélezVélez | 1 - 1 | CacereñoCacereño |
| 16 Aug 21 | r04 | BergantiñosBergantiños | - | CoruxoCoruxo |
| 18 Aug 21 | r04 | Sangiuliano CitySangiuliano C | 2 - 2 | Giana ErminioGiana Erminio |
| 18 Aug 21 | r04 | MurciaMurcia | 0 - 1 | HerculesHercules |
| 18 Aug 21 | r04 | LangreoLangreo | 0 - 2 | Unionistas de SalamancaUnionistas de |
| 18 Aug 21 | r04 | CD CoriaCD Coria | 1 - 1 | Salamanca UDSSalamanca UDS |
| 18 Aug 21 | r04 | Real Oviedo BReal Oviedo B | 0 - 1 | CearesCeares |
| 18 Aug 21 | r04 | ÁguilasÁguilas | 1 - 2 | Almeria BAlmeria B |
| 19 Aug 21 | r04 | Cristo AtléticoCristo Atléti | 3 - 1 | ZamoraZamora |
| 20 Aug 21 | r04 | Lleida EsportiuLleida Esport | 2 - 1 | FC AndorraFC Andorra |
| 20 Aug 21 | r04 | Leganés IILeganés II | 1 - 1 | Atlético Madrid BAtlético Madr |
| 20 Aug 21 | r04 | Real AvilésReal Avilés | 0 - 4 | LeonesaLeonesa |
| 20 Aug 21 | r04 | ArenteiroArenteiro | 1 - 1 | La CorunaLa Coruna |
| 20 Aug 21 | r04 | Xerez DeportivoXerez Deporti | 0 - 2 | Betis DeportivoBetis Deporti |
| 20 Aug 21 | r04 | Calvo SoteloCalvo Sotelo | 0 - 0 | Linares DeportivoLinares Depor |
| 20 Aug 21 | r04 | Burgos PromesasBurgos Promes | 3 - 1 | ZamoraZamora |
| 20 Aug 21 | r04 | ArdoiArdoi | - | Real UniónReal Unión |
| 21 Aug 21 | r04 | LinenseLinense | 2 - 0 | CordobaCordoba |
| 21 Aug 21 | r04 | ÁguilasÁguilas | 1 - 1 | UCAM MurciaUCAM Murcia |
| 21 Aug 21 | r04 | Xerez DeportivoXerez Deporti | 2 - 1 | San Fernando CDSan Fernando |
| 22 Aug 21 | r04 | Atlético BalearesAtlético Bale | - | CD Ibiza Islas PitiusasCD Ibiza Isla |
| 22 Aug 21 | r04 | Mancha RealMancha Real | - | CD ToledoCD Toledo |
| 23 Aug 21 | r04 | Sp Gijon BSp Gijon B | 2 - 0 | PolvorínPolvorín |
| 25 Aug 21 | r04 | Don BenitoDon Benito | 4 - 0 | Calvo SoteloCalvo Sotelo |
| 28 Aug 21 | r04 | CovadongaCovadonga | 0 - 3 | LangreoLangreo |
| 28 Aug 21 | r04 | KarmiotissaKarmiotissa | 2 - 0 | Akritas ChlorakasAkritas Chlor |
| 28 Aug 21 | r04 | Anagennisi DeryneiaAnagennisi De | 2 - 0 | Omonia AradippouOmonia Aradip |
| 28 Aug 21 | r04 | Enosis Neon ParalimniEnosis Neon P | 1 - 1 | Achyronas LiopetriouAchyronas Lio |
| 28 Aug 21 | r04 | Nea Salamis FamagustaNea Salamis F | 2 - 0 | Alki OrokliniAlki Oroklini |
| 28 Aug 21 | r04 | Haro DeportivoHaro Deportiv | 1 - 1 | NáxaraNáxara |
| 28 Aug 21 | r04 | CE EuropaCE Europa | 0 - 0 | OlotOlot |
| 28 Aug 21 | r04 | HerculesHercules | 1 - 2 | EldenseEldense |
| 29 Aug 21 | r04 | Mérida ADMérida AD | 0 - 0 | RecreativoRecreativo |
| 29 Aug 21 | r04 | CacereñoCacereño | 2 - 2 | Leganés IILeganés II |
| 31 Aug 21 | r04 | GuijueloGuijuelo | 0 - 1 | ZamoraZamora |
| 04 Sep 21 | r04 | Zejtun CorinthiansZejtun Corint | 0 - 2 | Pietà HotspursPietà Hotspur |
| 05 Sep 21 | r04 | GS ArconateseGS Arconatese | 0 - 0 | A.C. LegnanoA.C. Legnano |
| 09 Sep 21 | r04 | Tiferno LerchiTiferno Lerch | 3 - 1 | ArezzoArezzo |
| 03 Oct 21 | r04 | RodosRodos | 2 - 2 | Olympiakos VolouOlympiakos Vo |
| 09 Oct 21 | r04 | Arges PitestiArges Pitesti | 4 - 0 | ConcordiaConcordia |
| 12 Nov 21 | r04 | DiosgyorDiosgyor | 1 - 1 | SzolnokSzolnok |
| 23 Dec 21 | r04 | Khanh Hoa FCKhanh Hoa FC | 2 - 1 | Sai GonSai Gon |
| 23 Dec 21 | r04 | Nam DinhNam Dinh | 1 - 5 | Binh DuongBinh Duong |
| 25 Dec 21 | r04 | Khanh Hoa FCKhanh Hoa FC | 2 - 2 | Nam DinhNam Dinh |
| 25 Dec 21 | r04 | Binh DuongBinh Duong | 2 - 1 | Ba Ria Vung Tau FCBa Ria Vung T |
| 29 Dec 21 | r04 | UCAM MurciaUCAM Murcia | 3 - 0 | MurciaMurcia |
| 30 Dec 21 | r04 | NumanciaNumancia | 5 - 0 | Racing Rioja CFRacing Rioja |
| 30 Dec 21 | r04 | CampinenseCampinense | 1 - 1 | GloboGlobo |
Team 2021-2022 Schedules
League Table
List
Poster
= TV Listing 
= Event Thumb 
= Banner Image 
= Fanart Image 
= Timeline Details