| 17 Feb 20 | r03  | Real MonarchsReal Monarchs | 0 - 0 | Union OmahaUnion Omaha |
| 19 Feb 20 | r03 | Birmingham LegionBirmingham Le | 3 - 0 | Forward Madison FCForward Madis |
| 19 Feb 20 | r03 | Hartford AthleticHartford Athl | 5 - 1 | New England Revolution IINew England R |
| 19 Feb 20 | r03 | Louisville CityLouisville Ci | 1 - 1 | Union OmahaUnion Omaha |
| 20 Feb 20 | r03 | SamguraliSamgurali | 0 - 2 | JammerbugtJammerbugt |
| 22 Feb 20 | r03 | LíšeňLíšeň | 9 - 0 | Inter BratislavaInter Bratisl |
| 22 Feb 20 | r03 | ChikhuraChikhura | 2 - 2 | JammerbugtJammerbugt |
| 22 Feb 20 | r03 | Colorado SpringsColorado Spri | 0 - 1 | Union OmahaUnion Omaha |
| 22 Feb 20 | r03 | North Texas SCNorth Texas S | 1 - 0 | El Paso LocomotiveEl Paso Locom |
| 22 Feb 20 | r03 | New England Revolution IINew England R | 1 - 0 | Hartford AthleticHartford Athl |
| 22 Feb 20 | r03 | Swope Park RangersSwope Park Ra | 1 - 1 | Texas UnitedTexas United |
| 22 Feb 20 | r03 | Richmond KickersRichmond Kick | 0 - 1 | New York RB IINew York RB I |
| 22 Feb 20 | r03 | Memphis 901Memphis 901 | 3 - 1 | Forward Madison FCForward Madis |
| 23 Feb 20 | r03 | Charlotte IndependenceCharlotte Ind | 2 - 0 | Greenville Triumph SCGreenville Tr |
| 25 Feb 20 | r03 | North Texas SCNorth Texas S | 1 - 3 | Tulsa RoughnecksTulsa Roughne |
| 25 Feb 20 | r03 | Louisville CityLouisville Ci | 4 - 0 | Forward Madison FCForward Madis |
| 27 Feb 20 | r03 | North Texas SCNorth Texas S | 1 - 0 | Swope Park RangersSwope Park Ra |
| 29 Feb 20 | r03 | Tormenta FCTormenta FC | 1 - 1 | Charleston BatteryCharleston Ba |
| 29 Feb 20 | r03 | FV IllertissenFV Illertisse | 5 - 2 | FC PipinsriedFC Pipinsried |
| 29 Feb 20 | r03 | New York RB IINew York RB I | 3 - 0 | New England Revolution IINew England R |
| 29 Feb 20 | r03 | North Carolina FCNorth Carolin | 1 - 2 | Greenville Triumph SCGreenville Tr |
| 29 Feb 20 | r03 | Saint LouisSaint Louis | 2 - 1 | Forward Madison FCForward Madis |
| 07 Mar 20 | r03 | Bremer SVBremer SV | 0 - 6 | OldenburgOldenburg |
| 07 Mar 20 | r03 | Pittsburgh RiverhoundsPittsburgh Ri | 0 - 0 | Toronto FC IIToronto FC II |
| 15 Jul 20 | r03 | MTK HungariaMTK Hungaria | 5 - 1 | III Kerületi TVEIII Kerületi |
| 16 Jul 20 | r03 | SC CambuurSC Cambuur | 4 - 1 | Harkemase BoysHarkemase Boy |
| 18 Jul 20 | r03 | Stade PlabennécoisStade Plabenn | P - P | BrestBrest |
| 18 Jul 20 | r03 | FC ChamblyFC Chambly | 4 - 0 | AS Beauvais OiseAS Beauvais O |
| 18 Jul 20 | r03 | RadomljeRadomlje | 0 - 4 | MTK HungariaMTK Hungaria |
| 21 Jul 20 | r03 | De TreffersDe Treffers | 1 - 4 | De GraafschapDe Graafschap |
| 24 Jul 20 | r03 | Aviron Bayonnais FCAviron Bayonn | 1 - 2 | AjaccioAjaccio |
| 25 Jul 20 | r03 | FC Den BoschFC Den Bosch | 5 - 0 | De TreffersDe Treffers |
| 25 Jul 20 | r03 | RadomljeRadomlje | 0 - 4 | Budafoki MTEBudafoki MTE |
| 26 Jul 20 | r03 | RKVV EVVRKVV EVV | 0 - 2 | VVV-VenloVVV-Venlo |
| 28 Jul 20 | r03 | NAC BredaNAC Breda | 1 - 0 | Sparta NijkerkSparta Nijker |
| 28 Jul 20 | r03 | De TreffersDe Treffers | 0 - 1 | TOP OssTOP Oss |
| 01 Aug 20 | r03 | Olympique Marcquois FootbOlympique Mar | P - P | Stade de ReimsStade de Reim |
| 01 Aug 20 | r03 | Helmond SportHelmond Sport | 2 - 0 | VV UNAVV UNA |
| 01 Aug 20 | r03 | Bremer SVBremer SV | 0 - 4 | Viktoria BerlinViktoria Berl |
| 01 Aug 20 | r03 | VV ASWHVV ASWH | 1 - 0 | FC DordrechtFC Dordrecht |
| 01 Aug 20 | r03 | FCSR HaguenauFCSR Haguenau | P - P | StrasbourgStrasbourg |
| 02 Aug 20 | r03 | CeljeCelje | 4 - 0 | RadomljeRadomlje |
| 02 Aug 20 | r03 | Hannover IIHannover II | P - P | Bremer SVBremer SV |
| 04 Aug 20 | r03 | US Saint-OmerUS Saint-Omer | 0 - 3 | USL DunkerqueUSL Dunkerque |
| 04 Aug 20 | r03 | De TreffersDe Treffers | 0 - 2 | NEC NijmegenNEC Nijmegen |
| 05 Aug 20 | r03 | CaenCaen | 1 - 1 | Vannes OCVannes OC |
| 05 Aug 20 | r03 | Bourges 18Bourges 18 | P - P | AuxerreAuxerre |
| 05 Aug 20 | r03 | RKVV EVVRKVV EVV | 2 - 5 | Helmond SportHelmond Sport |
| 07 Aug 20 | r03 | FC TwenteFC Twente | 3 - 1 | Excelsior 31Excelsior 31 |
| 08 Aug 20 | r03 | Helmond SportHelmond Sport | 3 - 0 | SV OSS 20SV OSS 20 |
| 08 Aug 20 | r03 | Willem IIWillem II | P - P | IJsselmeervogelsIJsselmeervog |
| 08 Aug 20 | r03 | Quick BoysQuick Boys | 0 - 1 | SC TelstarSC Telstar |
| 09 Aug 20 | r03 | Atlas DelmenhorstAtlas Delmenh | 1 - 1 | Bremer SVBremer SV |
| 09 Aug 20 | r03 | SO RomorantinSO Romorantin | 0 - 2 | ChateaurouxChateauroux |
| 11 Aug 20 | r03 | VV UNAVV UNA | 1 - 3 | NEC NijmegenNEC Nijmegen |
| 11 Aug 20 | r03 | SV TECSV TEC | 1 - 0 | FC Den BoschFC Den Bosch |
| 11 Aug 20 | r03 | SC TelstarSC Telstar | 6 - 1 | HVV HollandiaHVV Hollandia |
| 12 Aug 20 | r03 | FC OlexandriaFC Olexandria | 3 - 1 | Kryvbas Kryvyi RihKryvbas Kryvy |
| 15 Aug 20 | r03 | Górnik PolkowiceGórnik Polkow | 1 - 5 | Miedz LegnicaMiedz Legnica |
| 15 Aug 20 | r03 | JammerbugtJammerbugt | 2 - 0 | ThistedThisted |
| 15 Aug 20 | r03 | Warrenpoint TownWarrenpoint T | P - P | BangorBangor |
| 15 Aug 20 | r03 | VV GemertVV Gemert | 1 - 1 | Helmond SportHelmond Sport |
| 15 Aug 20 | r03 | SSV JeddelohSSV Jeddeloh | 4 - 2 | VfL OldenburgVfL Oldenburg |
| 15 Aug 20 | r03 | FC PipinsriedFC Pipinsried | 2 - 2 | EichstättEichstätt |
| 15 Aug 20 | r03 | Pau FCPau FC | 0 - 2 | US Colomiers FootballUS Colomiers |
| 21 Aug 20 | r03 | ServetteServette | 8 - 0 | Thonon Évian F.C.Thonon Évian |
| 22 Aug 20 | r03 | BełchatówBełchatów | 1 - 1 | Skra CzęstochowaSkra Częstoch |
| 22 Aug 20 | r03 | Vendsyssel FFVendsyssel FF | 1 - 0 | JammerbugtJammerbugt |
| 25 Aug 20 | r03 | SSV JeddelohSSV Jeddeloh | P - P | VfL OldenburgVfL Oldenburg |
| 29 Aug 20 | r03 | VfR GarchingVfR Garching | 0 - 1 | FC PipinsriedFC Pipinsried |
| 30 Aug 20 | r03 | FC OlexandriaFC Olexandria | P - P | Kryvbas Kryvyi RihKryvbas Kryvy |
| 11 Sep 20 | r03 | SC EltersdorfSC Eltersdorf | 0 - 0 | SpVgg Greuther Fürth IISpVgg Greuthe |
| 11 Sep 20 | r03 | Warrenpoint TownWarrenpoint T | P - P | Armagh CityArmagh City |
| 07 Apr 21 | r03 | New England Rev.New England R | - | Seattle Sounders FCSeattle Sound |
| 07 Apr 21 | r03 | Inter MiamiInter Miami | 1 - 0 | Miami FCMiami FC |
| 07 Apr 21 | r03 | Chicago FireChicago Fire | 2 - 0 | Forward Madison FCForward Madis |
| 07 Apr 21 | r03 | New England Rev.New England R | 2 - 1 | LA Galaxy IILA Galaxy II |
| 07 Apr 21 | r03 | FC DallasFC Dallas | 3 - 3 | Austin FCAustin FC |
| 08 Apr 21 | r03 | SD AmorebietaSD Amorebieta | - | EibarEibar |
| 08 Apr 21 | r03 | CF MontréalCF Montréal | 0 - 2 | Tormenta FCTormenta FC |
| 09 Apr 21 | r03 | San Jose EarthquakesSan Jose Eart | 3 - 2 | Oakland RootsOakland Roots |
| 09 Apr 21 | r03 | Orlando CityOrlando City | 3 - 2 | Minnesota UnitedMinnesota Uni |
| 09 Apr 21 | r03 | Austin BoldAustin Bold | 1 - 1 | Rio Grande ValleyRio Grande Va |
| 10 Apr 21 | r03 | Birmingham LegionBirmingham Le | - | Nashville SCNashville SC |
| 10 Apr 21 | r03 | FC LahtiFC Lahti | 2 - 1 | KTPKTP |
| 10 Apr 21 | r03 | EIFEIF | - | MariehamnMariehamn |
| 10 Apr 21 | r03 | TPSTPS | 0 - 1 | HIFK FotbollHIFK Fotboll |
| 10 Apr 21 | r03 | Vancouver WhitecapsVancouver Whi | 3 - 2 | Chicago FireChicago Fire |
| 10 Apr 21 | r03 | New York CityNew York City | 2 - 0 | Hartford AthleticHartford Athl |
| 10 Apr 21 | r03 | Loudoun UnitedLoudoun Unite | - | Richmond KickersRichmond Kick |
| 10 Apr 21 | r03 | New York Red BullsNew York Red | 1 - 1 | DC UnitedDC United |
| 10 Apr 21 | r03 | Pittsburgh RiverhoundsPittsburgh Ri | 2 - 1 | FC CincinnatiFC Cincinnati |
| 10 Apr 21 | r03 | Indy ElevenIndy Eleven | - | Vancouver WhitecapsVancouver Whi |
| 10 Apr 21 | r03 | New Mexico UnitedNew Mexico Un | 4 - 2 | Colorado SpringsColorado Spri |
| 10 Apr 21 | r03 | Los Angeles FCLos Angeles F | 3 - 3 | New England Rev.New England R |
| 10 Apr 21 | r03 | OKC EnergyOKC Energy | 3 - 1 | North Texas SCNorth Texas S |
| 10 Apr 21 | r03 | Austin FCAustin FC | 5 - 1 | San AntonioSan Antonio |
| 10 Apr 21 | r03 | FC DallasFC Dallas | 3 - 0 | Houston DynamoHouston Dynam |
| 10 Apr 21 | r03 | Las Vegas LightsLas Vegas Lig | P - P | California United StrikerCalifornia Un |
| 11 Apr 21 | r03 | Seattle Sounders FCSeattle Sound | 1 - 0 | San Diego LoyalSan Diego Loy |
| 11 Apr 21 | r03 | Seattle Sounders FCSeattle Sound | - | LA Galaxy IILA Galaxy II |
| 11 Apr 21 | r03 | Austin FCAustin FC | 3 - 2 | Rio Grande ValleyRio Grande Va |
| 11 Apr 21 | r03 | CF MontréalCF Montréal | 5 - 1 | Tampa Bay RowdiesTampa Bay Row |
| 11 Apr 21 | r03 | Inter MiamiInter Miami | - | Miami FCMiami FC |
| 11 Apr 21 | r03 | Austin FCAustin FC | - | Louisville CityLouisville Ci |
| 11 Apr 21 | r03 | Seattle Sounders FCSeattle Sound | 1 - 0 | San Diego LoyalSan Diego Loy |
| 11 Apr 21 | r03 | Louisville CityLouisville Ci | 4 - 2 | Greenville Triumph SCGreenville Tr |
| 11 Apr 21 | r03 | El Paso LocomotiveEl Paso Locom | 3 - 1 | Colorado SpringsColorado Spri |
| 11 Apr 21 | r03 | Inter MiamiInter Miami | - | Toronto FCToronto FC |
| 12 Apr 21 | r03 | SiriusSirius | 6 - 0 | BrommapojkarnaBrommapojkarn |
| 12 Apr 21 | r03 | FC HakaFC Haka | 1 - 2 | SJK SeinajokiSJK Seinajoki |
| 13 Apr 21 | r03 | HJK HelsinkiHJK Helsinki | 4 - 0 | AC OuluAC Oulu |
| 15 Apr 21 | r03 | OKC EnergyOKC Energy | 0 - 1 | Austin BoldAustin Bold |
| 16 Apr 21 | r03 | Hartford AthleticHartford Athl | 2 - 1 | New York RB IINew York RB I |
| 16 Apr 21 | r03 | Charleston BatteryCharleston Ba | 2 - 1 | North Carolina FCNorth Carolin |
| 16 Apr 21 | r03 | El Paso LocomotiveEl Paso Locom | 1 - 3 | North Texas SCNorth Texas S |
| 17 Apr 21 | r03 | Phoenix RisingPhoenix Risin | - | Colorado SpringsColorado Spri |
| 17 Apr 21 | r03 | El Paso LocomotiveEl Paso Locom | - | FC DallasFC Dallas |
| 17 Apr 21 | r03 | RosenborgRosenborg | 3 - 0 | RaufossRaufoss |
| 17 Apr 21 | r03 | VaalerengaVaalerenga | - | KFUMKFUM |
| 17 Apr 21 | r03 | FC HakaFC Haka | - | KTPKTP |
| 17 Apr 21 | r03 | GnistanGnistan | 0 - 1 | HIFK FotbollHIFK Fotboll |
| 17 Apr 21 | r03 | StartStart | 2 - 3 | BryneBryne |
| 17 Apr 21 | r03 | MjoendalenMjoendalen | 5 - 2 | Grorud ILGrorud IL |
| 17 Apr 21 | r03 | MoldeMolde | 2 - 1 | Stjørdals-BlinkStjørdals-Bli |
| 17 Apr 21 | r03 | SogndalSogndal | 4 - 1 | BrannBrann |
| 17 Apr 21 | r03 | Kristiansund BKKristiansund | 0 - 3 | RanheimRanheim |
| 17 Apr 21 | r03 | Inter TurkuInter Turku | 1 - 0 | MariehamnMariehamn |
| 17 Apr 21 | r03 | SJK SeinajokiSJK Seinajoki | 3 - 0 | KPVKPV |
| 17 Apr 21 | r03 | VikingViking | 1 - 1 | ASANE FOTBALLASANE FOTBALL |
| 17 Apr 21 | r03 | Odd BallklubbOdd Ballklubb | 0 - 0 | SandefjordSandefjord |
| 17 Apr 21 | r03 | JERVJERV | 3 - 2 | SandnesSandnes |
| 17 Apr 21 | r03 | HJK HelsinkiHJK Helsinki | 1 - 2 | FC LahtiFC Lahti |
| 17 Apr 21 | r03 | North Texas SCNorth Texas S | 0 - 4 | El Paso LocomotiveEl Paso Locom |
| 17 Apr 21 | r03 | New Mexico UnitedNew Mexico Un | 3 - 1 | FC TucsonFC Tucson |
| 17 Apr 21 | r03 | Indy ElevenIndy Eleven | 3 - 0 | Forward Madison FCForward Madis |
| 17 Apr 21 | r03 | Orange County SCOrange County | 1 - 3 | LA Galaxy IILA Galaxy II |
| 17 Apr 21 | r03 | Greenville Triumph SCGreenville Tr | 2 - 1 | Charlotte IndependenceCharlotte Ind |
| 17 Apr 21 | r03 | Tulsa RoughnecksTulsa Roughne | 1 - 1 | Austin BoldAustin Bold |
| 17 Apr 21 | r03 | Louisville CityLouisville Ci | 2 - 0 | Pittsburgh RiverhoundsPittsburgh Ri |
| 17 Apr 21 | r03 | Union OmahaUnion Omaha | 2 - 1 | Swope Park RangersSwope Park Ra |
| 17 Apr 21 | r03 | Birmingham LegionBirmingham Le | 4 - 1 | Chattanooga Red Wolves SCChattanooga R |
| 17 Apr 21 | r03 | Richmond KickersRichmond Kick | - | Loudoun UnitedLoudoun Unite |
| 18 Apr 21 | r03 | Bodoe/GlimtBodoe/Glimt | 1 - 1 | TromsoTromso |
| 18 Apr 21 | r03 | RoPSRoPS | 1 - 2 | AC OuluAC Oulu |
| 18 Apr 21 | r03 | Sarpsborg 08Sarpsborg 08 | 2 - 2 | StabaekStabaek |
| 18 Apr 21 | r03 | StroemsgodsetStroemsgodset | 2 - 3 | LillestroemLillestroem |
| 18 Apr 21 | r03 | FredrikstadFredrikstad | 4 - 1 | Ull KisaUll Kisa |
| 18 Apr 21 | r03 | HamarkamerateneHamarkamerate | 2 - 0 | StrommenStrommen |
| 21 Apr 21 | r03 | MjoendalenMjoendalen | 4 - 0 | SandefjordSandefjord |
| 21 Apr 21 | r03 | AalesundAalesund | 1 - 0 | SogndalSogndal |
| 21 Apr 21 | r03 | Odd BallklubbOdd Ballklubb | 1 - 1 | JERVJERV |
| 21 Apr 21 | r03 | VaalerengaVaalerenga | 2 - 1 | Sarpsborg 08Sarpsborg 08 |
| 21 Apr 21 | r03 | RosenborgRosenborg | 2 - 1 | RanheimRanheim |
| 21 Apr 21 | r03 | Hartford AthleticHartford Athl | 3 - 3 | Bethlehem SteelBethlehem Ste |
| 21 Apr 21 | r03 | SandnesSandnes | 1 - 1 | VikingViking |
| 23 Apr 21 | r03 | Kristiansund BKKristiansund | 0 - 0 | MoldeMolde |
| 23 Apr 21 | r03 | RaufossRaufoss | 4 - 1 | HamarkamerateneHamarkamerate |
| 23 Apr 21 | r03 | North Carolina FCNorth Carolin | 0 - 1 | Charlotte IndependenceCharlotte Ind |
| 23 Apr 21 | r03 | KTPKTP | - | HIFK FotbollHIFK Fotboll |
| 24 Apr 21 | r03 | Hartford AthleticHartford Athl | - | FC MotownFC Motown |
| 24 Apr 21 | r03 | Las Vegas LightsLas Vegas Lig | - | Oakland RootsOakland Roots |
| 24 Apr 21 | r03 | KV OostendeKV Oostende | 0 - 3 | AnderlechtAnderlecht |
| 24 Apr 21 | r03 | KTPKTP | 0 - 1 | JIPPOJIPPO |
| 24 Apr 21 | r03 | IlvesIlves | 2 - 0 | MariehamnMariehamn |
| 24 Apr 21 | r03 | JJK JJK | 1 - 1 | MPMP |
| 24 Apr 21 | r03 | FC HakaFC Haka | 1 - 1 | Klubi-04Klubi-04 |
| 24 Apr 21 | r03 | FC LahtiFC Lahti | 4 - 2 | GnistanGnistan |
| 24 Apr 21 | r03 | StrommenStrommen | 2 - 2 | Grorud ILGrorud IL |
| 24 Apr 21 | r03 | SJK SeinajokiSJK Seinajoki | 1 - 1 | AC OuluAC Oulu |
| 24 Apr 21 | r03 | RoPSRoPS | 0 - 0 | JaroJaro |
| 24 Apr 21 | r03 | Indy ElevenIndy Eleven | 1 - 1 | Pittsburgh RiverhoundsPittsburgh Ri |
| 24 Apr 21 | r03 | San AntonioSan Antonio | 2 - 2 | Rio Grande ValleyRio Grande Va |
| 24 Apr 21 | r03 | Swope Park RangersSwope Park Ra | 0 - 1 | Forward Madison FCForward Madis |
| 24 Apr 21 | r03 | Phoenix RisingPhoenix Risin | 0 - 4 | New Mexico UnitedNew Mexico Un |
| 24 Apr 21 | r03 | Sacramento RepublicSacramento Re | 2 - 0 | Real MonarchsReal Monarchs |
| 24 Apr 21 | r03 | Memphis 901Memphis 901 | 1 - 2 | Chattanooga Red Wolves SCChattanooga R |
| 25 Apr 21 | r03 | Orange County SCOrange County | 2 - 2 | Colorado SpringsColorado Spri |
| 25 Apr 21 | r03 | RosenborgRosenborg | 1 - 0 | TromsoTromso |
| 25 Apr 21 | r03 | Phoenix RisingPhoenix Risin | 2 - 1 | FC TucsonFC Tucson |
| 25 Apr 21 | r03 | Bodoe/GlimtBodoe/Glimt | 4 - 1 | BrannBrann |
| 25 Apr 21 | r03 | MjoendalenMjoendalen | 1 - 4 | FredrikstadFredrikstad |
| 25 Apr 21 | r03 | VikingViking | 3 - 3 | StartStart |
| 25 Apr 21 | r03 | Odd BallklubbOdd Ballklubb | 1 - 0 | StabaekStabaek |
| 25 Apr 21 | r03 | FK HaugesundFK Haugesund | 1 - 1 | ASANE FOTBALLASANE FOTBALL |
| 25 Apr 21 | r03 | Bethlehem SteelBethlehem Ste | 4 - 2 | Loudoun UnitedLoudoun Unite |
| 26 Apr 21 | r03 | StroemsgodsetStroemsgodset | 1 - 0 | SandefjordSandefjord |
| 28 Apr 21 | r03 | HamarkamerateneHamarkamerate | 4 - 0 | Ull KisaUll Kisa |
| 28 Apr 21 | r03 | RosenborgRosenborg | 3 - 0 | Kristiansund BKKristiansund |
| 28 Apr 21 | r03 | MoldeMolde | 2 - 0 | SogndalSogndal |
| 28 Apr 21 | r03 | HamarkamerateneHamarkamerate | - | KongsvingerKongsvinger |
| 28 Apr 21 | r03 | VaalerengaVaalerenga | 6 - 1 | RaufossRaufoss |
| 28 Apr 21 | r03 | BrannBrann | 3 - 3 | SandnesSandnes |
| 28 Apr 21 | r03 | FredrikstadFredrikstad | 2 - 1 | StrommenStrommen |
| 29 Apr 21 | r03 | Las Vegas LightsLas Vegas Lig | - | San Diego 1904 FCSan Diego 190 |
| 29 Apr 21 | r03 | MPMP | 1 - 0 | PK-35PK-35 |
| 30 Apr 21 | r03 | North Carolina FCNorth Carolin | 2 - 1 | Charleston BatteryCharleston Ba |
| 01 May 21 | r03 | BryneBryne | 1 - 0 | JERVJERV |
| 01 May 21 | r03 | Pittsburgh RiverhoundsPittsburgh Ri | 4 - 2 | Bethlehem SteelBethlehem Ste |
| 02 May 21 | r03 | RanheimRanheim | 2 - 1 | RosenborgRosenborg |
| 02 May 21 | r03 | StroemsgodsetStroemsgodset | 1 - 6 | FredrikstadFredrikstad |
| 02 May 21 | r03 | SogndalSogndal | 3 - 4 | RaufossRaufoss |
| 02 May 21 | r03 | MjoendalenMjoendalen | 2 - 1 | LillestroemLillestroem |
| 02 May 21 | r03 | StabaekStabaek | 2 - 1 | HamarkamerateneHamarkamerate |
| 02 May 21 | r03 | StartStart | 1 - 1 | SandefjordSandefjord |
| 02 May 21 | r03 | Sarpsborg 08Sarpsborg 08 | 1 - 0 | Odd BallklubbOdd Ballklubb |
| 02 May 21 | r03 | MoldeMolde | 1 - 1 | Bodoe/GlimtBodoe/Glimt |
| 02 May 21 | r03 | ASANE FOTBALLASANE FOTBALL | 1 - 2 | BrannBrann |
| 02 May 21 | r03 | VaalerengaVaalerenga | 3 - 4 | TromsoTromso |
| 02 May 21 | r03 | Kristiansund BKKristiansund | 0 - 4 | AalesundAalesund |
| 02 May 21 | r03 | VikingViking | 4 - 0 | FK HaugesundFK Haugesund |
| 05 May 21 | r03 | HamarkamerateneHamarkamerate | 1 - 5 | RaufossRaufoss |
| 08 May 21 | r03 | SogndalSogndal | 0 - 1 | HamarkamerateneHamarkamerate |
| 08 May 21 | r03 | FredrikstadFredrikstad | 4 - 2 | Grorud ILGrorud IL |
| 08 May 21 | r03 | StrommenStrommen | 1 - 2 | KFUMKFUM |
| 08 May 21 | r03 | SandnesSandnes | 1 - 0 | BryneBryne |
| 08 May 21 | r03 | RaufossRaufoss | 2 - 1 | Ull KisaUll Kisa |
| 08 May 21 | r03 | RanheimRanheim | 1 - 2 | Stjørdals-BlinkStjørdals-Bli |
| 08 May 21 | r03 | MjoendalenMjoendalen | 1 - 1 | Sarpsborg 08Sarpsborg 08 |
| 09 May 21 | r03 | Memphis 901Memphis 901 | 5 - 0 | Little Rock RangersLittle Rock R |
| 09 May 21 | r03 | StartStart | 1 - 1 | FK HaugesundFK Haugesund |
| 09 May 21 | r03 | StabaekStabaek | 0 - 1 | LillestroemLillestroem |
| 26 May 21 | r03 | CharleroiCharleroi | 3 - 1 | FolaFola |
| 30 May 21 | r03 | TromsdalenTromsdalen | 2 - 1 | AltaAlta |
| 30 May 21 | r03 | Øygarden FKØygarden FK | 2 - 3 | HoeddHoedd |
| 01 Jun 21 | r03 | RaufossRaufoss | 4 - 4 | Ull KisaUll Kisa |
| 02 Jun 21 | r03 | SkeidSkeid | 2 - 4 | StabaekStabaek |
| 03 Jun 21 | r03 | LillestroemLillestroem | 5 - 0 | HamarkamerateneHamarkamerate |
| 04 Jun 21 | r03 | MjoendalenMjoendalen | 3 - 1 | Ull KisaUll Kisa |
| 04 Jun 21 | r03 | Stjørdals-BlinkStjørdals-Bli | 3 - 1 | LevangerLevanger |
| 05 Jun 21 | r03 | KongsvingerKongsvinger | 1 - 1 | SkeidSkeid |
| 05 Jun 21 | r03 | Phönix LübeckPhönix Lübeck | 4 - 1 | Teutonia OttensenTeutonia Otte |
| 07 Jun 21 | r03 | BrannBrann | 3 - 0 | Øygarden FKØygarden FK |
| 08 Jun 21 | r03 | RaufossRaufoss | 2 - 1 | KongsvingerKongsvinger |
| 12 Jun 21 | r03 | TromsdalenTromsdalen | 2 - 1 | AltaAlta |
| 12 Jun 21 | r03 | Malmo FFMalmo FF | 0 - 1 | Kalmar FFKalmar FF |
| 12 Jun 21 | r03 | Øygarden FKØygarden FK | 5 - 0 | FloroeFloroe |
| 12 Jun 21 | r03 | Chayka PeschanokopskoyeChayka Pescha | 2 - 0 | Akron TolyattiAkron Tolyatt |
| 12 Jun 21 | r03 | FC UfaFC Ufa | 0 - 2 | Veles MoscowVeles Moscow |
| 13 Jun 21 | r03 | HoeddHoedd | 2 - 0 | AalesundAalesund |
| 13 Jun 21 | r03 | BaerumBaerum | 0 - 3 | NotoddenNotodden |
| 13 Jun 21 | r03 | Eintracht Norderstedt 03Eintracht Nor | 3 - 3 | Heider SVHeider SV |
| 14 Jun 21 | r03 | Spartak-2 MoscowSpartak-2 Mos | 0 - 4 | Baltika KaliningradBaltika Kalin |
| 16 Jun 21 | r03 | FC UfaFC Ufa | 2 - 1 | Chayka PeschanokopskoyeChayka Pescha |
| 16 Jun 21 | r03 | Ludogorets RazgradLudogorets Ra | 2 - 0 | SV HeimstettenSV Heimstette |
| 17 Jun 21 | r03 | SV LafnitzSV Lafnitz | 1 - 2 | Videoton FC FehervarVideoton FC F |
| 18 Jun 21 | r03 | Sheriff TiraspolSheriff Tiras | 1 - 0 | Akron TolyattiAkron Tolyatt |
| 18 Jun 21 | r03 | Ħamrun SpartansĦamrun Sparta | 2 - 1 | SK Vorwarts SteyrSK Vorwarts S |
| 18 Jun 21 | r03 | RadomljeRadomlje | 1 - 1 | DomzaleDomzale |
| 19 Jun 21 | r03 | Lask Juniors LinzLask Juniors | 0 - 5 | Puskás Akadémia FCPuskás Akadém |
| 19 Jun 21 | r03 | Dukla PrahaDukla Praha | 2 - 0 | Sparta Prague BSparta Prague |
| 19 Jun 21 | r03 | Baltika KaliningradBaltika Kalin | 0 - 2 | FC UfaFC Ufa |
| 19 Jun 21 | r03 | Gaz Metan MediașGaz Metan Med | 1 - 2 | 1599 Șelimbăr1599 Șelimbăr |
| 19 Jun 21 | r03 | HackenHacken | 1 - 0 | OerebroOerebro |
| 19 Jun 21 | r03 | Eintracht Norderstedt 03Eintracht Nor | - | Hannoverscher SCHannoverscher |
| 19 Jun 21 | r03 | MjallbyMjallby | 1 - 2 | HalmstadHalmstad |
| 19 Jun 21 | r03 | DjurgaardenDjurgaarden | 2 - 3 | Kalmar FFKalmar FF |
| 19 Jun 21 | r03 | Malmo FFMalmo FF | 2 - 0 | ElfsborgElfsborg |
| 19 Jun 21 | r03 | Veles MoscowVeles Moscow | 0 - 2 | Volgar AstrakhanVolgar Astrak |
| 19 Jun 21 | r03 | Tatran Liptovský MikulášTatran Liptov | 2 - 1 | MFK Zemplín MichalovceMFK Zemplín M |
| 19 Jun 21 | r03 | Slavia SofiaSlavia Sofia | 3 - 0 | Marek DupnitsaMarek Dupnits |
| 19 Jun 21 | r03 | FC Trenkwalder AdmiraFC Trenkwalde | 4 - 0 | SV HornSV Horn |
| 19 Jun 21 | r03 | CFR Cluj-NapocaCFR Cluj-Napo | 1 - 1 | Ludogorets RazgradLudogorets Ra |
| 19 Jun 21 | r03 | Spartak-2 MoscowSpartak-2 Mos | 1 - 2 | SKA-KhabarovskSKA-Khabarovs |
| 19 Jun 21 | r03 | CSKA SofiaCSKA Sofia | 2 - 0 | Litex LovechLitex Lovech |
| 19 Jun 21 | r03 | TSC Bačka TopolaTSC Bačka Top | 2 - 3 | Spartak SuboticaSpartak Subot |
| 19 Jun 21 | r03 | NŠ MuraNŠ Mura | 0 - 4 | Dinamo ZagrebDinamo Zagreb |
| 20 Jun 21 | r03 | Gazovik OrenburgGazovik Orenb | 2 - 0 | Videoton FC FehervarVideoton FC F |
| 20 Jun 21 | r03 | AIKAIK | 3 - 3 | SiriusSirius |
| 20 Jun 21 | r03 | Legia WarsawLegia Warsaw | 0 - 2 | FerencvarosFerencvaros |
| 20 Jun 21 | r03 | SV KapfenbergSV Kapfenberg | 1 - 4 | Slovan BratislavaSlovan Bratis |
| 21 Jun 21 | r03 | Fakel VoronezhFakel Voronez | 3 - 1 | Torpedo MoscowTorpedo Mosco |
| 21 Jun 21 | r03 | PFC SochiPFC Sochi | 2 - 3 | FC Krasnodar-2FC Krasnodar- |
| 21 Jun 21 | r03 | Olimpija LjubljanaOlimpija Ljub | 1 - 1 | Neftçi PFKNeftçi PFK |
| 22 Jun 21 | r03 | NK MariborNK Maribor | - | Slovan BratislavaSlovan Bratis |
| 22 Jun 21 | r03 | Mladost LučaniMladost Lučan | 0 - 0 | KolubaraKolubara |
| 22 Jun 21 | r03 | HammarbyHammarby | 1 - 0 | Österlen FFÖsterlen FF |
| 22 Jun 21 | r03 | Lokomotiv Plovdiv Lokomotiv Plo | 3 - 1 | Septemvri SimitliSeptemvri Sim |
| 22 Jun 21 | r03 | MFK RužomberokMFK Ružombero | 3 - 0 | KosiceKosice |
| 22 Jun 21 | r03 | Spartak SuboticaSpartak Subot | 0 - 5 | Krylya Sovetov SamaraKrylya Soveto |
| 22 Jun 21 | r03 | SlovackoSlovacko | 6 - 1 | VyškovVyškov |
| 22 Jun 21 | r03 | CFR Cluj-NapocaCFR Cluj-Napo | 0 - 1 | Puskás Akadémia FCPuskás Akadém |
| 22 Jun 21 | r03 | Akron TolyattiAkron Tolyatt | 1 - 0 | Sfântul Gheorghe SuruceniSfântul Gheor |
| 22 Jun 21 | r03 | HarelbekeHarelbeke | 0 - 5 | KortrijkKortrijk |
| 22 Jun 21 | r03 | East KilbrideEast Kilbride | 2 - 1 | DumbartonDumbarton |
| 23 Jun 21 | r03 | Young BoysYoung Boys | - | SC KriensSC Kriens |
| 23 Jun 21 | r03 | DoradosDorados | 1 - 4 | TijuanaTijuana |
| 23 Jun 21 | r03 | Academica ClinceniAcademica Cli | 1 - 0 | Chindia TârgovișteChindia Târgo |
| 23 Jun 21 | r03 | KeçiörengücüKeçiörengücü | 1 - 4 | Dinamo Bucuresti Dinamo Bucure |
| 23 Jun 21 | r03 | RadomljeRadomlje | 2 - 2 | NK BravoNK Bravo |
| 23 Jun 21 | r03 | Farul ConstantaFarul Constan | 2 - 0 | FC BraşovFC Braşov |
| 23 Jun 21 | r03 | Volgar AstrakhanVolgar Astrak | 2 - 1 | Olimp-DolgoprudnyOlimp-Dolgopr |
| 23 Jun 21 | r03 | Rakow CzestochowaRakow Czestoc | 2 - 4 | Lechia GdańskLechia Gdańsk |
| 23 Jun 21 | r03 | Varbergs BoIS FCVarbergs BoIS | 1 - 0 | ElfsborgElfsborg |
| 23 Jun 21 | r03 | IFK GothenburgIFK Gothenbur | 1 - 2 | BrøndbyBrøndby |
| 23 Jun 21 | r03 | ZoryaZorya | 3 - 3 | FC OlexandriaFC Olexandria |
| 23 Jun 21 | r03 | Legia WarsawLegia Warsaw | 1 - 1 | FC KrasnodarFC Krasnodar |
| 23 Jun 21 | r03 | Ludogorets RazgradLudogorets Ra | 1 - 3 | FerencvarosFerencvaros |
| 23 Jun 21 | r03 | Chayka PeschanokopskoyeChayka Pescha | 5 - 1 | StavAgrosoyuzStavAgrosoyuz |
| 23 Jun 21 | r03 | Tsarsko SeloTsarsko Selo | 4 - 0 | Strumska SlavaStrumska Slav |
| 23 Jun 21 | r03 | CSKA 1948CSKA 1948 | 2 - 3 | Slavia SofiaSlavia Sofia |
| 23 Jun 21 | r03 | Lok. MoscowLok. Moscow | 3 - 2 | MSK ZilinaMSK Zilina |
| 23 Jun 21 | r03 | Tatran Liptovský MikulášTatran Liptov | 1 - 0 | FK PohronieFK Pohronie |
| 23 Jun 21 | r03 | VojvodinaVojvodina | 1 - 0 | Slask WroclawSlask Wroclaw |
| 23 Jun 21 | r03 | Wiener NeustadtWiener Neusta | 1 - 3 | CSKA MoscowCSKA Moscow |
| 23 Jun 21 | r03 | Radnički 1923Radnički 1923 | 1 - 0 | Novi PazarNovi Pazar |
| 23 Jun 21 | r03 | RijekaRijeka | 1 - 0 | DomzaleDomzale |
| 23 Jun 21 | r03 | ClachnacuddinClachnacuddin | 0 - 5 | Inverness CInverness C |
| 23 Jun 21 | r03 | East FifeEast Fife | 1 - 1 | TNSTNS |
| 24 Jun 21 | r03 | Dinamo ZagrebDinamo Zagreb | - | Slovan BratislavaSlovan Bratis |
| 24 Jun 21 | r03 | Dinamo ZagrebDinamo Zagreb | 3 - 0 | ŠKF SereďŠKF Sereď |
| 24 Jun 21 | r03 | Proleter Novi SadProleter Novi | 1 - 3 | Krylya Sovetov SamaraKrylya Soveto |
| 24 Jun 21 | r03 | Berliner AK 07Berliner AK 0 | 2 - 2 | Hertha ZehlendorfHertha Zehlen |
| 24 Jun 21 | r03 | FK Rubin KazanFK Rubin Kaza | 2 - 1 | Nizhny NovgorodNizhny Novgor |
| 24 Jun 21 | r03 | HOBROHOBRO | 1 - 0 | AaBAaB |
| 24 Jun 21 | r03 | NorrkopingNorrkoping | 1 - 0 | OerebroOerebro |
| 24 Jun 21 | r03 | FC CopenhagenFC Copenhagen | 1 - 1 | Hvidovre IFHvidovre IF |
| 24 Jun 21 | r03 | Gazovik OrenburgGazovik Orenb | 0 - 1 | Slovan BratislavaSlovan Bratis |
| 24 Jun 21 | r03 | FK RostovFK Rostov | 2 - 2 | Videoton FC FehervarVideoton FC F |
| 25 Jun 21 | r03 | LyngbyLyngby | - | Hvidovre IFHvidovre IF |
| 25 Jun 21 | r03 | HamburgHamburg | - | VSG AltglienickeVSG Altglieni |
| 25 Jun 21 | r03 | PaderbornPaderborn | - | DuisburgDuisburg |
| 25 Jun 21 | r03 | Baltika KaliningradBaltika Kalin | - | Neftekhimik NizhnekamskNeftekhimik N |
| 25 Jun 21 | r03 | Pirin BlagoevgradPirin Blagoev | 6 - 1 | Marek DupnitsaMarek Dupnits |
| 25 Jun 21 | r03 | Arda KardzhaliArda Kardzhal | 2 - 1 | Maritsa PlovdivMaritsa Plovd |
| 25 Jun 21 | r03 | Berliner FC DynamoBerliner FC D | 1 - 2 | Viktoria BerlinViktoria Berl |
| 25 Jun 21 | r03 | PumasPumas | - | FC JuarezFC Juarez |
| 25 Jun 21 | r03 | ChrudimChrudim | 1 - 0 | Vysočina JihlavaVysočina Jihl |
| 25 Jun 21 | r03 | InhuletsInhulets | 2 - 0 | FC Kolos KovalivkaFC Kolos Kova |
| 25 Jun 21 | r03 | Akron TolyattiAkron Tolyatt | 3 - 0 | FloreștiFlorești |
| 25 Jun 21 | r03 | FC U Craiova 1948FC U Craiova | 0 - 2 | FC UfaFC Ufa |
| 25 Jun 21 | r03 | MontanaMontana | 2 - 0 | Sportist SvogeSportist Svog |
| 25 Jun 21 | r03 | Berwick RangersBerwick Range | - | HeartsHearts |
| 25 Jun 21 | r03 | Uta AradUta Arad | 2 - 0 | 1599 Șelimbăr1599 Șelimbăr |
| 25 Jun 21 | r03 | Zaglebie LubinZaglebie Lubi | 0 - 3 | Pogon SzczecinPogon Szczeci |
| 25 Jun 21 | r03 | FC Lausanne-SportFC Lausanne-S | 4 - 2 | Neuchâtel XamaxNeuchâtel Xam |
| 25 Jun 21 | r03 | AnderlechtAnderlecht | 1 - 1 | St.TruidenSt.Truiden |
| 25 Jun 21 | r03 | ZurichZurich | 2 - 2 | FC WilFC Wil |
| 25 Jun 21 | r03 | FC LieferingFC Liefering | 1 - 2 | SV Josko RiedSV Josko Ried |
| 25 Jun 21 | r03 | GrasshoppersGrasshoppers | 2 - 4 | SchaffhausenSchaffhausen |
| 25 Jun 21 | r03 | Baltika KaliningradBaltika Kalin | 3 - 1 | Rotor VolgogradRotor Volgogr |
| 25 Jun 21 | r03 | NK AluminijNK Aluminij | 0 - 1 | Puskás Akadémia FCPuskás Akadém |
| 25 Jun 21 | r03 | Sturm GrazSturm Graz | 6 - 0 | Lask Juniors LinzLask Juniors |
| 25 Jun 21 | r03 | Neftekhimik NizhnekamskNeftekhimik N | 1 - 1 | Tekstilshchik IvanovoTekstilshchik |
| 25 Jun 21 | r03 | BeroeBeroe | 1 - 1 | Yantra GabrovoYantra Gabrov |
| 25 Jun 21 | r03 | SochauxSochaux | 3 - 0 | F91 DudelangeF91 Dudelange |
| 25 Jun 21 | r03 | SV SalzburgSV Salzburg | 3 - 1 | DAC 1904 Dunajská StredaDAC 1904 Duna |
| 25 Jun 21 | r03 | Germania HalberstadtGermania Halb | 1 - 3 | BraunschweigBraunschweig |
| 26 Jun 21 | r03 | MFK RužomberokMFK Ružombero | - | Wisla KrakowWisla Krakow |
| 26 Jun 21 | r03 | Tatran Liptovský MikulášTatran Liptov | - | ŠKF SereďŠKF Sereď |
| 26 Jun 21 | r03 | MFK Zemplín MichalovceMFK Zemplín M | - | KosiceKosice |
| 26 Jun 21 | r03 | Cimarrones de SonoraCimarrones de | - | TijuanaTijuana |
| 26 Jun 21 | r03 | CD GuadalajaraCD Guadalajar | - | NecaxaNecaxa |
| 26 Jun 21 | r03 | Kispest HonvedKispest Honve | 1 - 0 | AjkaAjka |
| 26 Jun 21 | r03 | MTK HungariaMTK Hungaria | 7 - 2 | III Kerületi TVEIII Kerületi |
| 26 Jun 21 | r03 | Farul ConstantaFarul Constan | 1 - 1 | Rapid BucurestiRapid Bucures |
| 26 Jun 21 | r03 | Sparta PragueSparta Prague | - | Dukla PrahaDukla Praha |
| 26 Jun 21 | r03 | KolubaraKolubara | 0 - 1 | Metalac GMMetalac GM |
| 26 Jun 21 | r03 | KazincbarcikaKazincbarcika | 1 - 3 | Kisvárda FCKisvárda FC |
| 26 Jun 21 | r03 | Civil Service StrollersCivil Service | 2 - 2 | DunfermlineDunfermline |
| 26 Jun 21 | r03 | ClachnacuddinClachnacuddin | - | Broxburn Athletic F.C.Broxburn Athl |
| 26 Jun 21 | r03 | Wuerzburger KickersWuerzburger K | 1 - 2 | SandhausenSandhausen |
| 26 Jun 21 | r03 | GlentoranGlentoran | 1 - 0 | ColeraineColeraine |
| 26 Jun 21 | r03 | Kelty HeartsKelty Hearts | 2 - 3 | PartickPartick |
| 26 Jun 21 | r03 | Raith RvsRaith Rvs | 4 - 1 | StranraerStranraer |
| 26 Jun 21 | r03 | Khimki FKKhimki FK | 0 - 1 | Olimp-DolgoprudnyOlimp-Dolgopr |
| 26 Jun 21 | r03 | Alianza LimaAlianza Lima | 0 - 0 | Academia Deportiva CantolAcademia Depo |
| 26 Jun 21 | r03 | VorsklaVorskla | 3 - 0 | SC Dnipro-1SC Dnipro-1 |
| 26 Jun 21 | r03 | MynaiMynai | 0 - 2 | FC LvivFC Lviv |
| 26 Jun 21 | r03 | Tekstilshchik IvanovoTekstilshchik | 2 - 0 | FC RyazanFC Ryazan |
| 26 Jun 21 | r03 | Universitatea CraiovaUniversitatea | 1 - 2 | Hajduk SplitHajduk Split |
| 26 Jun 21 | r03 | LeonLeon | 1 - 3 | MoreliaMorelia |
| 26 Jun 21 | r03 | Wacker InnsbruckWacker Innsbr | 0 - 1 | CSKA SofiaCSKA Sofia |
| 26 Jun 21 | r03 | NŠ MuraNŠ Mura | 2 - 2 | Partizan BelgradePartizan Belg |
| 26 Jun 21 | r03 | Apollon LimassolApollon Limas | 3 - 4 | Omonia NicosiaOmonia Nicosi |
| 26 Jun 21 | r03 | NK BravoNK Bravo | 1 - 3 | MSK ZilinaMSK Zilina |
| 26 Jun 21 | r03 | ŠibenikŠibenik | 2 - 1 | ZrinjskiZrinjski |
| 26 Jun 21 | r03 | DečićDečić | 1 - 1 | Spartak SuboticaSpartak Subot |
| 26 Jun 21 | r03 | Buducnost PodgoricaBuducnost Pod | 3 - 2 | Krylya Sovetov SamaraKrylya Soveto |
| 26 Jun 21 | r03 | Buducnost PodgoricaBuducnost Pod | 2 - 1 | Radnički 1923Radnički 1923 |
| 26 Jun 21 | r03 | CSA Steaua BucureştiCSA Steaua Bu | 1 - 2 | Academica ClinceniAcademica Cli |
| 26 Jun 21 | r03 | Fakel VoronezhFakel Voronez | 1 - 1 | Veles MoscowVeles Moscow |
| 26 Jun 21 | r03 | Levski Sofia Levski Sofia | 1 - 0 | Lokomotiv Plovdiv Lokomotiv Plo |
| 26 Jun 21 | r03 | Tsarsko SeloTsarsko Selo | 4 - 1 | Minyor PernikMinyor Pernik |
| 26 Jun 21 | r03 | Cherno MoreCherno More | 1 - 0 | CSKA 1948CSKA 1948 |
| 26 Jun 21 | r03 | Viktoria PlzenViktoria Plze | 4 - 1 | FC Spartak TrnavaFC Spartak Tr |
| 26 Jun 21 | r03 | SlovackoSlovacko | 5 - 0 | ProstějovProstějov |
| 26 Jun 21 | r03 | PardubicePardubice | 0 - 2 | Zbrojovka BrnoZbrojovka Brn |
| 26 Jun 21 | r03 | Sigma OlomoucSigma Olomouc | 3 - 0 | VyškovVyškov |
| 26 Jun 21 | r03 | Wisla PlockWisla Plock | - | Rakow CzestochowaRakow Czestoc |
| 26 Jun 21 | r03 | Hradec KrálovéHradec Králov | 3 - 1 | Bohemians 1905Bohemians 190 |
| 26 Jun 21 | r03 | LiberecLiberec | 5 - 0 | Viktoria ŽižkovViktoria Žižk |
| 26 Jun 21 | r03 | OsijekOsijek | 1 - 2 | Slask WroclawSlask Wroclaw |
| 26 Jun 21 | r03 | Wisla KrakowWisla Krakow | 3 - 2 | Stal MielecStal Mielec |
| 26 Jun 21 | r03 | KarvinaKarvina | 0 - 3 | TrencinTrencin |
| 26 Jun 21 | r03 | Cracovia KrakowCracovia Krak | 2 - 0 | TřinecTřinec |
| 26 Jun 21 | r03 | AC HorsensAC Horsens | 1 - 1 | Randers FCRanders FC |
| 26 Jun 21 | r03 | FC WinterthurFC Winterthur | 2 - 5 | VaduzVaduz |
| 26 Jun 21 | r03 | Optik RathenowOptik Ratheno | 2 - 2 | Tennis Borussia BerlinTennis Boruss |
| 26 Jun 21 | r03 | PaderbornPaderborn | 5 - 1 | SC VerlSC Verl |
| 26 Jun 21 | r03 | DumbartonDumbarton | 1 - 0 | MotherwellMotherwell |
| 26 Jun 21 | r03 | AGF AarhusAGF Aarhus | 0 - 1 | FC NordsjællandFC Nordsjælla |
| 26 Jun 21 | r03 | AaBAaB | 2 - 2 | ViborgViborg |
| 26 Jun 21 | r03 | Dynamo DresdenDynamo Dresde | 3 - 1 | Hertha IIHertha II |
| 26 Jun 21 | r03 | Jong UtrechtJong Utrecht | 1 - 1 | Jong AZJong AZ |
| 26 Jun 21 | r03 | ForfarForfar | 0 - 3 | Dundee FCDundee FC |
| 26 Jun 21 | r03 | HannoverHannover | 0 - 2 | St PauliSt Pauli |
| 26 Jun 21 | r03 | MontroseMontrose | 1 - 1 | ArbroathArbroath |
| 26 Jun 21 | r03 | Eintracht Norderstedt 03Eintracht Nor | - | Teutonia OttensenTeutonia Otte |
| 26 Jun 21 | r03 | FC HeidenheimFC Heidenheim | 5 - 4 | Austria LustenauAustria Luste |
| 26 Jun 21 | r03 | FC Krasnodar-2FC Krasnodar- | 0 - 1 | FC Forte TaganrogFC Forte Taga |
| 26 Jun 21 | r03 | NurnbergNurnberg | 5 - 1 | ZwickauZwickau |
| 26 Jun 21 | r03 | SKN St. PoltenSKN St. Polte | 0 - 2 | NK AluminijNK Aluminij |
| 26 Jun 21 | r03 | WaregemWaregem | 0 - 4 | St. GilloiseSt. Gilloise |
| 26 Jun 21 | r03 | FC Trenkwalder AdmiraFC Trenkwalde | 0 - 4 | Slovan BratislavaSlovan Bratis |
| 26 Jun 21 | r03 | SV LafnitzSV Lafnitz | 2 - 5 | Rapid ViennaRapid Vienna |
| 26 Jun 21 | r03 | Austria ViennaAustria Vienn | 2 - 1 | SK Vorwarts SteyrSK Vorwarts S |
| 26 Jun 21 | r03 | Jahn RegensburgJahn Regensbu | 4 - 0 | FC BW LinzFC BW Linz |
| 26 Jun 21 | r03 | Gazovik OrenburgGazovik Orenb | 4 - 1 | FK Senica FK Senica |
| 26 Jun 21 | r03 | Wolfsberger ACWolfsberger A | 1 - 0 | OlympiakosOlympiakos |
| 26 Jun 21 | r03 | Petrocub HînceștiPetrocub Hînc | 1 - 0 | Akron TolyattiAkron Tolyatt |
| 26 Jun 21 | r03 | Lok. MoscowLok. Moscow | 6 - 1 | Olimpija LjubljanaOlimpija Ljub |
| 26 Jun 21 | r03 | Club BruggeClub Brugge | 1 - 1 | Beerschot VABeerschot VA |
| 26 Jun 21 | r03 | CFR Cluj-NapocaCFR Cluj-Napo | 1 - 0 | Dinamo MoscowDinamo Moscow |
| 26 Jun 21 | r03 | Slaven Belupo KoprivnicaSlaven Belupo | 1 - 1 | Slask WroclawSlask Wroclaw |
| 26 Jun 21 | r03 | CeljeCelje | 0 - 1 | HNK GoricaHNK Gorica |
| 26 Jun 21 | r03 | USL DunkerqueUSL Dunkerque | 1 - 1 | Cercle BruggeCercle Brugge |
| 26 Jun 21 | r03 | Mladost LučaniMladost Lučan | 1 - 2 | VoždovacVoždovac |
| 26 Jun 21 | r03 | RijekaRijeka | 3 - 0 | Hrvatski DragovoljacHrvatski Drag |
| 26 Jun 21 | r03 | NK MariborNK Maribor | 4 - 1 | VojvodinaVojvodina |
| 27 Jun 21 | r03 | Ural S.RUral S.R | - | FK Rubin KazanFK Rubin Kaza |
| 27 Jun 21 | r03 | CancúnCancún | 1 - 1 | MonterreyMonterrey |
| 27 Jun 21 | r03 | ZoryaZorya | 1 - 2 | Proleter Novi SadProleter Novi |
| 27 Jun 21 | r03 | VfV HildesheimVfV Hildeshei | - | Chemie LeipzigChemie Leipzi |
| 27 Jun 21 | r03 | Volgar AstrakhanVolgar Astrak | 1 - 2 | FC Yenisey KrasnoyarskFC Yenisey Kr |
| 27 Jun 21 | r03 | Spartak-2 MoscowSpartak-2 Mos | 7 - 0 | Chertanovo MoscowChertanovo Mo |
| 27 Jun 21 | r03 | Malmo FFMalmo FF | 1 - 2 | FC MidtjyllandFC Midtjyllan |
| 27 Jun 21 | r03 | Eintracht Norderstedt 03Eintracht Nor | - | St PauliSt Pauli |
| 27 Jun 21 | r03 | FC BaselFC Basel | 2 - 3 | ThunThun |
| 27 Jun 21 | r03 | HammarbyHammarby | 3 - 1 | SiriusSirius |
| 27 Jun 21 | r03 | Ludogorets RazgradLudogorets Ra | 3 - 0 | LASKLASK |
| 27 Jun 21 | r03 | Botev PlovdivBotev Plovdiv | 1 - 1 | ZoryaZorya |
| 27 Jun 21 | r03 | Malmo FFMalmo FF | 2 - 0 | KøgeKøge |
| 27 Jun 21 | r03 | SV KapfenbergSV Kapfenberg | 0 - 1 | CSKA MoscowCSKA Moscow |
| 27 Jun 21 | r03 | FC KrasnodarFC Krasnodar | 0 - 1 | OlympiakosOlympiakos |
| 27 Jun 21 | r03 | Dinamo ZagrebDinamo Zagreb | 2 - 1 | FK RostovFK Rostov |
| 27 Jun 21 | r03 | RadomljeRadomlje | 0 - 1 | CukarickiCukaricki |
| 27 Jun 21 | r03 | Novi PazarNovi Pazar | 2 - 2 | KF Vllaznia ShkodërKF Vllaznia S |
| 27 Jun 21 | r03 | Tabor SežanaTabor Sežana | 0 - 2 | TSC Bačka TopolaTSC Bačka Top |
| 28 Jun 21 | r03 | DegerforsDegerfors | 2 - 2 | DjurgaardenDjurgaarden |
| 28 Jun 21 | r03 | Alania VladikavkazAlania Vladik | - | Chayka PeschanokopskoyeChayka Pescha |
| 28 Jun 21 | r03 | FredericiaFredericia | 0 - 4 | MjallbyMjallby |
| 28 Jun 21 | r03 | AIKAIK | 0 - 1 | OstersundOstersund |
| 28 Jun 21 | r03 | SiriusSirius | 0 - 2 | HammarbyHammarby |
| 28 Jun 21 | r03 | BrøndbyBrøndby | 4 - 1 | SønderjyskeSønderjyske |
| 28 Jun 21 | r03 | HackenHacken | 0 - 2 | HalmstadHalmstad |
| 28 Jun 21 | r03 | Young BoysYoung Boys | 4 - 1 | Neuchâtel XamaxNeuchâtel Xam |
| 28 Jun 21 | r03 | Baltika KaliningradBaltika Kalin | 2 - 0 | Torpedo MoscowTorpedo Mosco |
| 28 Jun 21 | r03 | Cherno MoreCherno More | 0 - 0 | Strumska SlavaStrumska Slav |
| 28 Jun 21 | r03 | CFR Cluj-NapocaCFR Cluj-Napo | 1 - 1 | Újpest FCÚjpest FC |
| 28 Jun 21 | r03 | Crvena ZvezdaCrvena Zvezda | 4 - 0 | Grazer AKGrazer AK |
| 29 Jun 21 | r03 | Saturn RamenskoyeSaturn Ramens | 0 - 3 | Tekstilshchik IvanovoTekstilshchik |
| 29 Jun 21 | r03 | Vejle BoldklubVejle Boldklu | 0 - 5 | Silkeborg IFSilkeborg IF |
| 29 Jun 21 | r03 | Wolfsberger ACWolfsberger A | 0 - 0 | FC UfaFC Ufa |
| 29 Jun 21 | r03 | VolynVolyn | 0 - 0 | Veres RivneVeres Rivne |
| 29 Jun 21 | r03 | HelsingborgHelsingborg | 2 - 0 | Varbergs BoIS FCVarbergs BoIS |
| 29 Jun 21 | r03 | Tekstilshchik IvanovoTekstilshchik | 0 - 2 | Veles MoscowVeles Moscow |
| 29 Jun 21 | r03 | Rotor VolgogradRotor Volgogr | 2 - 0 | TomskTomsk |
| 29 Jun 21 | r03 | CSKA 1948CSKA 1948 | 2 - 3 | Shkendija 79Shkendija 79 |
| 29 Jun 21 | r03 | WSG Swarovski TirolWSG Swarovski | 1 - 3 | FC U Craiova 1948FC U Craiova |
| 29 Jun 21 | r03 | NK BravoNK Bravo | 1 - 1 | Universitatea CraiovaUniversitatea |
| 29 Jun 21 | r03 | LarneLarne | 1 - 2 | ColeraineColeraine |
| 29 Jun 21 | r03 | Raith RvsRaith Rvs | 0 - 1 | ClydeClyde |
| 29 Jun 21 | r03 | LiberecLiberec | 1 - 3 | Dukla PrahaDukla Praha |
| 29 Jun 21 | r03 | FC CopenhagenFC Copenhagen | 3 - 1 | LyngbyLyngby |
| 29 Jun 21 | r03 | AhrobiznesAhrobiznes | 1 - 1 | FC LvivFC Lviv |
| 29 Jun 21 | r03 | SlovackoSlovacko | 3 - 0 | Tatran Liptovský MikulášTatran Liptov |
| 29 Jun 21 | r03 | Neftekhimik NizhnekamskNeftekhimik N | 2 - 0 | Shinnik YaroslavlShinnik Yaros |
| 29 Jun 21 | r03 | Spartak MoscowSpartak Mosco | 1 - 2 | Neftçi PFKNeftçi PFK |
| 29 Jun 21 | r03 | Pogon SzczecinPogon Szczeci | 0 - 1 | MFK RužomberokMFK Ružombero |
| 29 Jun 21 | r03 | Gazovik OrenburgGazovik Orenb | 1 - 2 | GyirmótGyirmót |
| 29 Jun 21 | r03 | SochauxSochaux | - | CA PontarlierCA Pontarlier |
| 29 Jun 21 | r03 | SV SalzburgSV Salzburg | 3 - 0 | OlympiakosOlympiakos |
| 29 Jun 21 | r03 | Hajduk SplitHajduk Split | 4 - 0 | Slask WroclawSlask Wroclaw |
| 29 Jun 21 | r03 | NæsbyNæsby | 1 - 3 | Odense BKOdense BK |
| 29 Jun 21 | r03 | Olimpija LjubljanaOlimpija Ljub | - | Borac Banja LukaBorac Banja L |
| 29 Jun 21 | r03 | DumbartonDumbarton | 0 - 0 | MortonMorton |
| 29 Jun 21 | r03 | MontroseMontrose | - | FraserburghFraserburgh |
| 30 Jun 21 | r03 | PEC ZwollePEC Zwolle | 1 - 1 | Dortmund IIDortmund II |
| 30 Jun 21 | r03 | Jagiellonia BialystokJagiellonia B | - | Znicz PruszkówZnicz Pruszkó |
| 30 Jun 21 | r03 | CD GuadalajaraCD Guadalajar | - | TapatíoTapatío |
| 30 Jun 21 | r03 | Gornik ZabrzeGornik Zabrze | - | Podbeskidzie Bielsko-BialPodbeskidzie |
| 30 Jun 21 | r03 | FC Yenisey KrasnoyarskFC Yenisey Kr | - | Olimp-DolgoprudnyOlimp-Dolgopr |
| 30 Jun 21 | r03 | NecaxaNecaxa | 8 - 1 | Mineros de ZacatecasMineros de Za |
| 30 Jun 21 | r03 | MonterreyMonterrey | 4 - 0 | VenadosVenados |
| 30 Jun 21 | r03 | Volgar AstrakhanVolgar Astrak | 1 - 2 | Fakel VoronezhFakel Voronez |
| 30 Jun 21 | r03 | Kispest HonvedKispest Honve | 4 - 1 | BudaörsBudaörs |
| 30 Jun 21 | r03 | Farul ConstantaFarul Constan | 1 - 0 | CS MioveniCS Mioveni |
| 30 Jun 21 | r03 | Viktoria ŽižkovViktoria Žižk | 2 - 0 | TáborskoTáborsko |
| 30 Jun 21 | r03 | KarvinaKarvina | 1 - 2 | Gornik ZabrzeGornik Zabrze |
| 30 Jun 21 | r03 | Steaua BucurestiSteaua Bucure | 5 - 1 | ACS SirineasaACS Sirineasa |
| 30 Jun 21 | r03 | LinfieldLinfield | 0 - 1 | KilmarnockKilmarnock |
| 30 Jun 21 | r03 | Beerschot VABeerschot VA | 2 - 1 | SC VerlSC Verl |
| 30 Jun 21 | r03 | BraunschweigBraunschweig | 3 - 3 | Hertha IIHertha II |
| 30 Jun 21 | r03 | Sparta PragueSparta Prague | 4 - 1 | Nurnberg IINurnberg II |
| 30 Jun 21 | r03 | Khimki FKKhimki FK | 0 - 1 | Fakel VoronezhFakel Voronez |
| 30 Jun 21 | r03 | EupenEupen | 2 - 1 | RFC SeraingRFC Seraing |
| 30 Jun 21 | r03 | InhuletsInhulets | 2 - 0 | Kryvbas Kryvyi RihKryvbas Kryvy |
| 30 Jun 21 | r03 | SKA-KhabarovskSKA-Khabarovs | 2 - 1 | TomskTomsk |
| 30 Jun 21 | r03 | VoždovacVoždovac | 0 - 1 | Metalac GMMetalac GM |
| 30 Jun 21 | r03 | MechelenMechelen | 2 - 7 | FC UtrechtFC Utrecht |
| 30 Jun 21 | r03 | VitesseVitesse | 1 - 3 | AEKAEK |
| 30 Jun 21 | r03 | PFC SochiPFC Sochi | 1 - 2 | PFC Kuban KrasnodarPFC Kuban Kra |
| 30 Jun 21 | r03 | RabotnichkiRabotnichki | 0 - 0 | Napredak KruševacNapredak Kruš |
| 30 Jun 21 | r03 | Farul ConstantaFarul Constan | 1 - 2 | Chindia TârgovișteChindia Târgo |
| 30 Jun 21 | r03 | PachucaPachuca | - | PumasPumas |
| 30 Jun 21 | r03 | HamburgHamburg | 1 - 0 | Wacker InnsbruckWacker Innsbr |
| 30 Jun 21 | r03 | FerencvarosFerencvaros | 1 - 0 | DAC 1904 Dunajská StredaDAC 1904 Duna |
| 30 Jun 21 | r03 | SKN St. PoltenSKN St. Polte | 1 - 1 | Újpest FCÚjpest FC |
| 30 Jun 21 | r03 | Tennis Borussia BerlinTennis Boruss | 1 - 8 | MagdeburgMagdeburg |
| 30 Jun 21 | r03 | SV HeimstettenSV Heimstette | 2 - 8 | Munich 1860Munich 1860 |
| 30 Jun 21 | r03 | BékéscsabaBékéscsaba | 1 - 2 | Kisvárda FCKisvárda FC |
| 30 Jun 21 | r03 | SozopolSozopol | 1 - 6 | Pirin BlagoevgradPirin Blagoev |
| 30 Jun 21 | r03 | EichstättEichstätt | 0 - 4 | IngolstadtIngolstadt |
| 30 Jun 21 | r03 | FolaFola | 2 - 1 | FC SaarbrückenFC Saarbrücke |
| 30 Jun 21 | r03 | Partizan BelgradePartizan Belg | 3 - 0 | KoperKoper |
| 30 Jun 21 | r03 | Krylya Sovetov SamaraKrylya Soveto | 3 - 0 | Radnički NišRadnički Niš |
| 30 Jun 21 | r03 | Bohemians 1905Bohemians 190 | 3 - 5 | VlašimVlašim |
| 30 Jun 21 | r03 | TepliceTeplice | - | VarnsdorfVarnsdorf |
| 30 Jun 21 | r03 | LiberecLiberec | 3 - 1 | Ústí nad LabemÚstí nad Labe |
| 30 Jun 21 | r03 | Stal MielecStal Mielec | 4 - 1 | Puszcza NiepołomicePuszcza Niepo |
| 30 Jun 21 | r03 | AaBAaB | 0 - 0 | EsbjergEsbjerg |
| 30 Jun 21 | r03 | Dynamo DresdenDynamo Dresde | 3 - 1 | JablonecJablonec |
| 30 Jun 21 | r03 | Legia WarsawLegia Warsaw | 3 - 2 | Lechia GdańskLechia Gdańsk |
| 30 Jun 21 | r03  | Viktoria PlzenViktoria Plze | 3 - 0 | PribramPribram |
| 30 Jun 21 | r03 | Cherno MoreCherno More | 3 - 2 | Arda KardzhaliArda Kardzhal |
| 30 Jun 21 | r03 | St.TruidenSt.Truiden | 2 - 1 | Lierse KempenzonenLierse Kempen |
| 30 Jun 21 | r03 | Optik RathenowOptik Ratheno | 1 - 1 | SV BabelsbergSV Babelsberg |
| 30 Jun 21 | r03 | FC HeidenheimFC Heidenheim | 2 - 0 | SC Rheindorf AltachSC Rheindorf |
| 30 Jun 21 | r03 | Hansa RostockHansa Rostock | 9 - 1 | Berliner AK 07Berliner AK 0 |
| 30 Jun 21 | r03 | Lech PoznanLech Poznan | 3 - 1 | Zaglebie LubinZaglebie Lubi |
| 30 Jun 21 | r03 | PardubicePardubice | 1 - 1 | Mlada BoleslavMlada Bolesla |
| 30 Jun 21 | r03 | Lokomotiv Plovdiv Lokomotiv Plo | 1 - 2 | BeroeBeroe |
| 30 Jun 21 | r03 | HannoverHannover | 1 - 0 | Viktoria BerlinViktoria Berl |
| 30 Jun 21 | r03 | Botev PlovdivBotev Plovdiv | 1 - 1 | Proleter Novi SadProleter Novi |
| 30 Jun 21 | r03 | HNK GoricaHNK Gorica | 1 - 1 | Uta AradUta Arad |
| 30 Jun 21 | r03 | Lucerne Lucerne | 2 - 4 | SC KriensSC Kriens |
| 30 Jun 21 | r03 | Paksi FCPaksi FC | 7 - 2 | III Kerületi TVEIII Kerületi |
| 30 Jun 21 | r03 | AjaccioAjaccio | 2 - 1 | FC Bastia-BorgoFC Bastia-Bor |
| 30 Jun 21 | r03 | Dynamo České BudějoviceDynamo České | 0 - 4 | Dinamo MoscowDinamo Moscow |
| 30 Jun 21 | r03 | FK PohronieFK Pohronie | 3 - 2 | ViOn Zlaté MoravceViOn Zlaté Mo |
| 30 Jun 21 | r03 | StandardStandard | 0 - 0 | St. GilloiseSt. Gilloise |
| 30 Jun 21 | r03 | Club BruggeClub Brugge | 2 - 1 | NK LokomotivaNK Lokomotiva |
| 30 Jun 21 | r03 | LuckenwaldeLuckenwalde | 5 - 1 | Union FürstenwaldeUnion Fürsten |
| 30 Jun 21 | r03 | NŠ MuraNŠ Mura | - | Arges PitestiArges Pitesti |
| 30 Jun 21 | r03 | OlympiakosOlympiakos | 2 - 1 | CSKA SofiaCSKA Sofia |
| 30 Jun 21 | r03 | Germania HalberstadtGermania Halb | 0 - 6 | Hallescher FCHallescher FC |
| 30 Jun 21 | r03 | RijekaRijeka | 2 - 2 | MSK ZilinaMSK Zilina |
| 30 Jun 21 | r03 | ŠibenikŠibenik | 0 - 1 | TSC Bačka TopolaTSC Bačka Top |
| 30 Jun 21 | r03 | Szombathelyi HaladásSzombathelyi | 1 - 1 | Zalaegerszegi TEZalaegerszegi |
| 30 Jun 21 | r03 | NŠ MuraNŠ Mura | 1 - 1 | VojvodinaVojvodina |
| 30 Jun 21 | r03 | Spartak SuboticaSpartak Subot | 2 - 2 | Radnik SurdulicaRadnik Surdul |
| 30 Jun 21 | r03 | OldenburgOldenburg | 0 - 4 | Werder BremenWerder Bremen |
| 30 Jun 21 | r03 | TSV HartbergTSV Hartberg | 0 - 0 | SK Vorwarts SteyrSK Vorwarts S |
| 30 Jun 21 | r03 | Bahlinger SCBahlinger SC | 0 - 0 | KarlsruheKarlsruhe |
| 30 Jun 21 | r03 | Zlatibor ČajetinaZlatibor Čaje | 0 - 3 | Mladost LučaniMladost Lučan |
| 30 Jun 21 | r03 | Novi PazarNovi Pazar | 0 - 0 | Rudar PljevljaRudar Pljevlj |
| 30 Jun 21 | r03 | Chemie LeipzigChemie Leipzi | 1 - 7 | ZwickauZwickau |
| 30 Jun 21 | r03 | Slovan BratislavaSlovan Bratis | 1 - 1 | ZlínZlín |
| 01 Jul 21 | r03 | MetaloglobusMetaloglobus | - | ZoryaZorya |
| 01 Jul 21 | r03 | F.C. Paços de FerreiraF.C. Paços de | - | VarzimVarzim |
| 01 Jul 21 | r03 | Torpedo MoscowTorpedo Mosco | 2 - 0 | Dynamo BryanskDynamo Bryans |
| 01 Jul 21 | r03 | AGF AarhusAGF Aarhus | 3 - 2 | HOBROHOBRO |
| 01 Jul 21 | r03 | Harrogate Town FCHarrogate Tow | 0 - 5 | DoncasterDoncaster |
| 01 Jul 21 | r03 | Steaua BucurestiSteaua Bucure | 4 - 1 | ConcordiaConcordia |
| 01 Jul 21 | r03 | Eintracht Norderstedt 03Eintracht Nor | 2 - 4 | Berliner AK 07Berliner AK 0 |
| 01 Jul 21 | r03 | Lask Juniors LinzLask Juniors | 2 - 5 | Wuerzburger KickersWuerzburger K |
| 01 Jul 21 | r03 | NK MariborNK Maribor | 1 - 3 | Cracovia KrakowCracovia Krak |
| 01 Jul 21 | r03 | DomzaleDomzale | 3 - 2 | Tuzla CityTuzla City |
| 01 Jul 21 | r03 | HerstedøsterHerstedøster | 0 - 5 | BrøndbyBrøndby |
| 01 Jul 21 | r03 | SGISGI | 0 - 1 | EsbjergEsbjerg |
| 01 Jul 21 | r03 | AGF AarhusAGF Aarhus | - | FC MidtjyllandFC Midtjyllan |
| 01 Jul 21 | r03 | Sparta PragueSparta Prague | 1 - 0 | LíšeňLíšeň |
| 01 Jul 21 | r03 | Slavia SofiaSlavia Sofia | 1 - 2 | Hebar PazardzhikHebar Pazardz |
| 01 Jul 21 | r03 | Arsenal TulaArsenal Tula | 1 - 3 | CukarickiCukaricki |
| 01 Jul 21 | r03 | FC KrasnodarFC Krasnodar | 1 - 2 | Sepsi OSK Sfântu GheorgheSepsi OSK Sfâ |
| 01 Jul 21 | r03 | Puskás Akadémia FCPuskás Akadém | 2 - 0 | FC Spartak TrnavaFC Spartak Tr |
| 01 Jul 21 | r03 | NŠ MuraNŠ Mura | 0 - 4 | FK RostovFK Rostov |
| 01 Jul 21 | r03 | Crvena ZvezdaCrvena Zvezda | 2 - 1 | ArisAris |
| 01 Jul 21 | r03 | OsijekOsijek | 1 - 1 | Videoton FC FehervarVideoton FC F |
| 01 Jul 21 | r03 | FC BaselFC Basel | 4 - 4 | Dynamo KievDynamo Kiev |
| 02 Jul 21 | r03 | Austria KlagenfurtAustria Klage | - | FC BW LinzFC BW Linz |
| 02 Jul 21 | r03 | Atlético NacionalAtlético Naci | 2 - 2 | Jaguares de CórdobaJaguares de C |
| 02 Jul 21 | r03 | Rapid BucurestiRapid Bucures | 2 - 1 | CS MioveniCS Mioveni |
| 02 Jul 21 | r03 | AnderlechtAnderlecht | - | KV OostendeKV Oostende |
| 02 Jul 21 | r03 | LyngbyLyngby | 2 - 3 | NykøbingNykøbing |
| 02 Jul 21 | r03 | SønderjyskeSønderjyske | - | ViborgViborg |
| 02 Jul 21 | r03 | FC WilFC Wil | 1 - 2 | GrasshoppersGrasshoppers |
| 02 Jul 21 | r03 | Cherno MoreCherno More | 4 - 3 | BeroeBeroe |
| 02 Jul 21 | r03 | VitesseVitesse | 1 - 3 | NK LokomotivaNK Lokomotiva |
| 02 Jul 21 | r03 | Yverdon SportYverdon Sport | 2 - 4 | FC SionFC Sion |
| 02 Jul 21 | r03 | Zlatibor ČajetinaZlatibor Čaje | 2 - 3 | Metalac GMMetalac GM |
| 02 Jul 21 | r03 | FC LvivFC Lviv | 2 - 1 | Veres RivneVeres Rivne |
| 02 Jul 21 | r03 | SC Dnipro-1SC Dnipro-1 | 1 - 1 | FC OlexandriaFC Olexandria |
| 02 Jul 21 | r03 | Tekstilshchik IvanovoTekstilshchik | 0 - 3 | FC Yenisey KrasnoyarskFC Yenisey Kr |
| 02 Jul 21 | r03 | Újpest FCÚjpest FC | 1 - 0 | FC VoluntariFC Voluntari |
| 02 Jul 21 | r03 | Dinamo MoscowDinamo Moscow | 1 - 0 | AEL LimassolAEL Limassol |
| 02 Jul 21 | r03 | Apollon LimassolApollon Limas | - | Anorthosis FamagustaAnorthosis Fa |
| 02 Jul 21 | r03 | CeljeCelje | 0 - 0 | Universitatea CraiovaUniversitatea |
| 02 Jul 21 | r03 | DomzaleDomzale | 2 - 1 | ŠibenikŠibenik |
| 02 Jul 21 | r03 | NiecieczaNieciecza | 2 - 3 | Hapoel Beer ShevaHapoel Beer S |
| 02 Jul 21 | r03 | OsnabrueckOsnabrueck | 7 - 3 | SSV JeddelohSSV Jeddeloh |
| 02 Jul 21 | r03 | UniversitarioUniversitario | - | CC Deportivo MunicipalCC Deportivo |
| 02 Jul 21 | r03 | Kolding IFKolding IF | 3 - 2 | JammerbugtJammerbugt |
| 02 Jul 21 | r03 | GlentoranGlentoran | 3 - 0 | DundelaDundela |
| 02 Jul 21 | r03 | Civil Service StrollersCivil Service | 3 - 5 | HibernianHibernian |
| 02 Jul 21 | r03 | FC BraşovFC Braşov | - | CS MioveniCS Mioveni |
| 02 Jul 21 | r03 | FC WilFC Wil | - | VaduzVaduz |
| 02 Jul 21 | r03 | AC HorsensAC Horsens | 0 - 0 | Silkeborg IFSilkeborg IF |
| 02 Jul 21 | r03 | MechelenMechelen | - | St.TruidenSt.Truiden |
| 02 Jul 21 | r03 | Nizhny NovgorodNizhny Novgor | 0 - 3 | FK Rubin KazanFK Rubin Kaza |
| 02 Jul 21 | r03 | SC Heracles AlmeloSC Heracles A | 1 - 2 | SpartaSparta |
| 02 Jul 21 | r03 | FC U Craiova 1948FC U Craiova | 0 - 1 | SV HornSV Horn |
| 02 Jul 21 | r03 | Sturm GrazSturm Graz | 9 - 1 | FC LieferingFC Liefering |
| 02 Jul 21 | r03 | Holstein KielHolstein Kiel | 1 - 2 | Randers FCRanders FC |
| 02 Jul 21 | r03 | Pogon SzczecinPogon Szczeci | 2 - 1 | Warta PoznańWarta Poznań |
| 02 Jul 21 | r03 | FC WilFC Wil | 7 - 1 | Austria LustenauAustria Luste |
| 02 Jul 21 | r03 | Le HavreLe Havre | 0 - 2 | AmiensAmiens |
| 02 Jul 21 | r03 | ValenciennesValenciennes | 0 - 0 | USL DunkerqueUSL Dunkerque |
| 02 Jul 21 | r03 | Gazovik OrenburgGazovik Orenb | 2 - 2 | SlovackoSlovacko |
| 02 Jul 21 | r03 | SV Josko RiedSV Josko Ried | 1 - 0 | Munich 1860Munich 1860 |
| 02 Jul 21 | r03 | Sturm GrazSturm Graz | 1 - 3 | FC BW LinzFC BW Linz |
| 02 Jul 21 | r03 | Spartak MoscowSpartak Mosco | 2 - 2 | NK BravoNK Bravo |
| 02 Jul 21 | r03 | DijonDijon | 1 - 2 | SochauxSochaux |
| 02 Jul 21 | r03 | OlympiakosOlympiakos | 1 - 1 | FC UfaFC Ufa |
| 02 Jul 21 | r03 | WaregemWaregem | 1 - 2 | Cercle BruggeCercle Brugge |
| 03 Jul 21 | r03 | Sportfreunde LotteSportfreunde | 0 - 2 | SV MeppenSV Meppen |
| 03 Jul 21 | r03 | Viktoria PlzenViktoria Plze | - | AueAue |
| 03 Jul 21 | r03 | Arda KardzhaliArda Kardzhal | - | Botev VratsaBotev Vratsa |
| 03 Jul 21 | r03 | SKN St. PoltenSKN St. Polte | - | Arges PitestiArges Pitesti |
| 03 Jul 21 | r03 | Radnik SurdulicaRadnik Surdul | - | MornarMornar |
| 03 Jul 21 | r03 | Alianza LimaAlianza Lima | - | FBC MelgarFBC Melgar |
| 03 Jul 21 | r03 | Farul ConstantaFarul Constan | 1 - 1 | CsikszeredaCsikszereda |
| 03 Jul 21 | r03 | Arda KardzhaliArda Kardzhal | 1 - 1 | Strumska SlavaStrumska Slav |
| 03 Jul 21 | r03 | ChrudimChrudim | 3 - 1 | Viktoria ŽižkovViktoria Žižk |
| 03 Jul 21 | r03 | VizelaVizela | 2 - 3 | Gil VicenteGil Vicente |
| 03 Jul 21 | r03 | MoreirenseMoreirense | 1 - 0 | F.C. Paços de FerreiraF.C. Paços de |
| 03 Jul 21 | r03 | KolubaraKolubara | 4 - 1 | Rudar PljevljaRudar Pljevlj |
| 03 Jul 21 | r03 | JablonecJablonec | 2 - 0 | VarnsdorfVarnsdorf |
| 03 Jul 21 | r03 | VfR GarchingVfR Garching | 0 - 6 | Nurnberg IINurnberg II |
| 03 Jul 21 | r03 | VlašimVlašim | 1 - 1 | Vysočina JihlavaVysočina Jihl |
| 03 Jul 21 | r03 | DiosgyorDiosgyor | 3 - 2 | Kisvárda FCKisvárda FC |
| 03 Jul 21 | r03 | GyirmótGyirmót | 1 - 0 | III Kerületi TVEIII Kerületi |
| 03 Jul 21 | r03 | Gaz Metan MediașGaz Metan Med | 0 - 1 | FC HermannstadtFC Hermannsta |
| 03 Jul 21 | r03 | Chayka PeschanokopskoyeChayka Pescha | - | PFC Spartak NalchikPFC Spartak N |
| 03 Jul 21 | r03 | ThunThun | 3 - 0 | Stade Lausanne OuchyStade Lausann |
| 03 Jul 21 | r03 | GuimaraesGuimaraes | 2 - 1 | FeirenseFeirense |
| 03 Jul 21 | r03 | SC HeerenveenSC Heerenveen | 3 - 1 | Jong UtrechtJong Utrecht |
| 03 Jul 21 | r03 | VfB AuerbachVfB Auerbach | 1 - 1 | SpVgg Greuther Fürth IISpVgg Greuthe |
| 03 Jul 21 | r03 | KarlsruheKarlsruhe | 5 - 1 | Viktoria KölnViktoria Köln |
| 03 Jul 21 | r03 | FC EilenburgFC Eilenburg | 0 - 5 | Hallescher FCHallescher FC |
| 03 Jul 21 | r03 | East KilbrideEast Kilbride | 1 - 2 | PartickPartick |
| 03 Jul 21 | r03 | AntwerpAntwerp | - | FC UtrechtFC Utrecht |
| 03 Jul 21 | r03 | LinfieldLinfield | 0 - 3 | St MirrenSt Mirren |
| 03 Jul 21 | r03 | Altona 93Altona 93 | 1 - 2 | Randers FCRanders FC |
| 03 Jul 21 | r03 | MagdeburgMagdeburg | 3 - 3 | Viktoria BerlinViktoria Berl |
| 03 Jul 21 | r03 | SC VerlSC Verl | 3 - 0 | BielefeldBielefeld |
| 03 Jul 21 | r03 | Beerschot VABeerschot VA | 0 - 1 | DuisburgDuisburg |
| 03 Jul 21 | r03 | Brechin CityBrechin City | 1 - 4 | Dundee UnitedDundee United |
| 03 Jul 21 | r03 | Raith RvsRaith Rvs | 2 - 2 | Queens ParkQueens Park |
| 03 Jul 21 | r03 | Queen of SouthQueen of Sout | 2 - 1 | StranraerStranraer |
| 03 Jul 21 | r03 | Chindia TârgovișteChindia Târgo | 1 - 3 | Steaua BucurestiSteaua Bucure |
| 03 Jul 21 | r03 | UzhhorodUzhhorod | 3 - 2 | VorsklaVorskla |
| 03 Jul 21 | r03 | LarneLarne | 2 - 2 | KilmarnockKilmarnock |
| 03 Jul 21 | r03 | EupenEupen | 1 - 1 | FC SaarbrückenFC Saarbrücke |
| 03 Jul 21 | r03 | Elgin CityElgin City | 0 - 5 | Ross CountyRoss County |
| 03 Jul 21 | r03 | Farul ConstantaFarul Constan | 0 - 1 | PetrolulPetrolul |
| 03 Jul 21 | r03 | BraunschweigBraunschweig | 0 - 1 | Dynamo DresdenDynamo Dresde |
| 03 Jul 21 | r03 | GrödigGrödig | 0 - 0 | SK Vorwarts SteyrSK Vorwarts S |
| 03 Jul 21 | r03 | LivingstonLivingston | 3 - 0 | East StirlingshireEast Stirling |
| 03 Jul 21 | r03 | HeartsHearts | 4 - 0 | FalkirkFalkirk |
| 03 Jul 21 | r03 | Cusco FCCusco FC | 1 - 2 | Universidad César VallejoUniversidad C |
| 03 Jul 21 | r03 | CaenCaen | 1 - 0 | AS Beauvais OiseAS Beauvais O |
| 03 Jul 21 | r03 | VoždovacVoždovac | 0 - 0 | Rudar PljevljaRudar Pljevlj |
| 03 Jul 21 | r03 | ChornomoretsChornomorets | 2 - 0 | BalkanyBalkany |
| 03 Jul 21 | r03 | LeonLeon | 0 - 3 | NecaxaNecaxa |
| 03 Jul 21 | r03 | WSG Swarovski TirolWSG Swarovski | 0 - 1 | FC BotoșaniFC Botoșani |
| 03 Jul 21 | r03 | DobrudzhaDobrudzha | - | Pirin BlagoevgradPirin Blagoev |
| 03 Jul 21 | r03 | Proleter Novi SadProleter Novi | - | MariupolMariupol |
| 03 Jul 21 | r03 | Levski Sofia Levski Sofia | 1 - 1 | Botev PlovdivBotev Plovdiv |
| 03 Jul 21 | r03 | Atlético NacionalAtlético Naci | 0 - 0 | Rionegro ÁguilasRionegro Águi |
| 03 Jul 21 | r03 | KAMAZ Naberezhnye ChelnyKAMAZ Naberez | 1 - 1 | FC ChelyabinskFC Chelyabins |
| 03 Jul 21 | r03 | Radnik SurdulicaRadnik Surdul | 2 - 2 | SlobodaSloboda |
| 03 Jul 21 | r03 | VV KatwijkVV Katwijk | 1 - 2 | Jong AZJong AZ |
| 03 Jul 21 | r03 | Wisla PlockWisla Plock | 1 - 1 | Omonia NicosiaOmonia Nicosi |
| 03 Jul 21 | r03 | FC Krasnodar-2FC Krasnodar- | 1 - 2 | PFC Kuban KrasnodarPFC Kuban Kra |
| 03 Jul 21 | r03 | AlloaAlloa | 0 - 0 | MortonMorton |
| 03 Jul 21 | r03 | Cruz AzulCruz Azul | 1 - 1 | FC JuarezFC Juarez |
| 03 Jul 21 | r03 | DebrecenDebrecen | 3 - 1 | TiszakécskeTiszakécske |
| 03 Jul 21 | r03 | NiceNice | 1 - 1 | Rodez AFRodez AF |
| 03 Jul 21 | r03 | AuxerreAuxerre | 3 - 0 | EpinalEpinal |
| 03 Jul 21 | r03 | Tabor SežanaTabor Sežana | 4 - 5 | Radnički NišRadnički Niš |
| 03 Jul 21 | r03 | TijuanaTijuana | 3 - 3 | PachucaPachuca |
| 03 Jul 21 | r03 | FC Krasnodar-2FC Krasnodar- | 1 - 0 | FC Chernomorets NovorossiFC Chernomore |
| 03 Jul 21 | r03 | KFUM RoskildeKFUM Roskilde | - | KøgeKøge |
| 03 Jul 21 | r03 | Septemvri SimitliSeptemvri Sim | 1 - 2 | CSKA 1948CSKA 1948 |
| 03 Jul 21 | r03 | Sigma OlomoucSigma Olomouc | 2 - 0 | Zbrojovka BrnoZbrojovka Brn |
| 03 Jul 21 | r03 | SFC OpavaSFC Opava | 0 - 1 | KarvinaKarvina |
| 03 Jul 21 | r03 | Banik OstravaBanik Ostrava | 3 - 0 | ProstějovProstějov |
| 03 Jul 21 | r03 | TáborskoTáborsko | 2 - 1 | Dynamo České BudějoviceDynamo České |
| 03 Jul 21 | r03 | LKS LodzLKS Lodz | 2 - 0 | Stal MielecStal Mielec |
| 03 Jul 21 | r03 | Paksi FCPaksi FC | 5 - 2 | PécsPécs |
| 03 Jul 21 | r03 | Mlada BoleslavMlada Bolesla | 2 - 0 | PribramPribram |
| 03 Jul 21 | r03 | FK PohronieFK Pohronie | 2 - 1 | KosiceKosice |
| 03 Jul 21 | r03 | SSV JeddelohSSV Jeddeloh | 1 - 4 | VfL OldenburgVfL Oldenburg |
| 03 Jul 21 | r03 | Gornik ZabrzeGornik Zabrze | 3 - 0 | Puszcza NiepołomicePuszcza Niepo |
| 03 Jul 21 | r03 | LiberecLiberec | 3 - 1 | Sparta Prague BSparta Prague |
| 03 Jul 21 | r03 | OsijekOsijek | 0 - 0 | Zalaegerszegi TEZalaegerszegi |
| 03 Jul 21 | r03 | Neftekhimik NizhnekamskNeftekhimik N | 3 - 1 | Spartak-2 MoscowSpartak-2 Mos |
| 03 Jul 21 | r03 | ZurichZurich | 0 - 1 | FC AarauFC Aarau |
| 03 Jul 21 | r03 | ZlínZlín | 1 - 1 | TrencinTrencin |
| 03 Jul 21 | r03 | Piast GliwicePiast Gliwice | 3 - 0 | Sandecja Nowy SaczSandecja Nowy |
| 03 Jul 21 | r03 | Jagiellonia BialystokJagiellonia B | 0 - 2 | Legia WarsawLegia Warsaw |
| 03 Jul 21 | r03 | Korona KielceKorona Kielce | 3 - 2 | Zaglebie SosnowiecZaglebie Sosn |
| 03 Jul 21 | r03 | FC WinterthurFC Winterthur | 1 - 3 | Lucerne Lucerne |
| 03 Jul 21 | r03 | TepliceTeplice | - | Bohemians 1905Bohemians 190 |
| 03 Jul 21 | r03 | Odense BKOdense BK | 7 - 0 | Fremad AmagerFremad Amager |
| 03 Jul 21 | r03 | Union FürstenwaldeUnion Fürsten | 3 - 2 | Lichtenberg 47Lichtenberg 4 |
| 03 Jul 21 | r03 | PardubicePardubice | 3 - 1 | Dukla PrahaDukla Praha |
| 03 Jul 21 | r03 | Sigma OlomoucSigma Olomouc | 2 - 1 | ŠKF SereďŠKF Sereď |
| 03 Jul 21 | r03 | Hannover IIHannover II | 1 - 2 | Chemnitzer FCChemnitzer FC |
| 03 Jul 21 | r03 | Jahn RegensburgJahn Regensbu | 4 - 0 | SpVgg BayreuthSpVgg Bayreut |
| 03 Jul 21 | r03 | Viktoria AschaffenburgViktoria Asch | - | Wehen WiesbadenWehen Wiesbad |
| 03 Jul 21 | r03 | Wacker InnsbruckWacker Innsbr | 1 - 3 | NurnbergNurnberg |
| 03 Jul 21 | r03 | Banik OstravaBanik Ostrava | 2 - 2 | TřinecTřinec |
| 03 Jul 21 | r03 | Vejle BoldklubVejle Boldklu | 1 - 1 | AaBAaB |
| 03 Jul 21 | r03 | Go Ahead EaglesGo Ahead Eagl | 1 - 1 | RKC WaalwijkRKC Waalwijk |
| 03 Jul 21 | r03 | Lech PoznanLech Poznan | 0 - 1 | Lechia GdańskLechia Gdańsk |
| 03 Jul 21 | r03 | ThunThun | 1 - 2 | SC KriensSC Kriens |
| 03 Jul 21 | r03 | FC Lausanne-SportFC Lausanne-S | 1 - 1 | Dynamo KievDynamo Kiev |
| 03 Jul 21 | r03 | Eintracht CelleEintracht Cel | 3 - 1 | Tennis Borussia BerlinTennis Boruss |
| 03 Jul 21 | r03 | Hansa RostockHansa Rostock | 3 - 1 | LuckenwaldeLuckenwalde |
| 03 Jul 21 | r03 | HannoverHannover | 1 - 1 | PaderbornPaderborn |
| 03 Jul 21 | r03 | Schwarz-Weiß RehdenSchwarz-Weiß | 0 - 5 | OsnabrueckOsnabrueck |
| 03 Jul 21 | r03 | Kelty HeartsKelty Hearts | 1 - 1 | MontroseMontrose |
| 03 Jul 21 | r03 | St PauliSt Pauli | - | PEC ZwollePEC Zwolle |
| 03 Jul 21 | r03 | Berliner FC DynamoBerliner FC D | 5 - 1 | Eintracht Norderstedt 03Eintracht Nor |
| 03 Jul 21 | r03 | Wolfsberger ACWolfsberger A | 1 - 3 | RijekaRijeka |
| 03 Jul 21 | r03 | Spennymoor Town FCSpennymoor To | 2 - 2 | SunderlandSunderland |
| 03 Jul 21 | r03 | Hitchin TownHitchin Town | 0 - 7 | LutonLuton |
| 03 Jul 21 | r03 | AZ AlkmaarAZ Alkmaar | 4 - 1 | NEC NijmegenNEC Nijmegen |
| 03 Jul 21 | r03 | ChrudimChrudim | - | VlašimVlašim |
| 03 Jul 21 | r03 | Schalke 04Schalke 04 | 0 - 0 | Zenit St PetersburgZenit St Pete |
| 03 Jul 21 | r03 | OlympiakosOlympiakos | 2 - 0 | FC U Craiova 1948FC U Craiova |
| 03 Jul 21 | r03 | SC Rheindorf AltachSC Rheindorf | 1 - 3 | St. GallenSt. Gallen |
| 03 Jul 21 | r03 | ClydeClyde | 3 - 1 | Albion RoversAlbion Rovers |
| 03 Jul 21 | r03 | SV SalzburgSV Salzburg | 1 - 3 | MonacoMonaco |
| 03 Jul 21 | r03 | Rapid ViennaRapid Vienna | 0 - 0 | Lok. MoscowLok. Moscow |
| 03 Jul 21 | r03 | StandardStandard | 3 - 2 | Cercle BruggeCercle Brugge |
| 03 Jul 21 | r03 | Chemie LeipzigChemie Leipzi | 4 - 1 | Beitar JerusalemBeitar Jerusa |
| 03 Jul 21 | r03 | Tsarsko SeloTsarsko Selo | 0 - 0 | Lokomotiv SofiaLokomotiv Sof |
| 03 Jul 21 | r03 | ServetteServette | 2 - 2 | Neuchâtel XamaxNeuchâtel Xam |
| 03 Jul 21 | r03 | TroyesTroyes | 1 - 2 | Clermont FootClermont Foot |
| 03 Jul 21 | r03 | Tatran Liptovský MikulášTatran Liptov | 1 - 3 | Wisla KrakowWisla Krakow |
| 03 Jul 21 | r03 | LASKLASK | 3 - 0 | Dinamo MoscowDinamo Moscow |
| 03 Jul 21 | r03 | TSV HartbergTSV Hartberg | 3 - 2 | SV LafnitzSV Lafnitz |
| 03 Jul 21 | r03 | DAC 1904 Dunajská StredaDAC 1904 Duna | 4 - 2 | Szombathelyi HaladásSzombathelyi |
| 03 Jul 21 | r03 | HNK GoricaHNK Gorica | 0 - 2 | VojvodinaVojvodina |
| 03 Jul 21 | r03 | QuevillyQuevilly | 0 - 3 | AjaccioAjaccio |
| 03 Jul 21 | r03 | Club BruggeClub Brugge | 0 - 1 | KortrijkKortrijk |
| 03 Jul 21 | r03 | NK AluminijNK Aluminij | 1 - 2 | Uta AradUta Arad |
| 04 Jul 21 | r03 | Lokomotiv Plovdiv Lokomotiv Plo | - | Yantra GabrovoYantra Gabrov |
| 04 Jul 21 | r03 | Mladost LučaniMladost Lučan | 1 - 0 | Spartak SuboticaSpartak Subot |
| 04 Jul 21 | r03 | MoreliaMorelia | 1 - 3 | PumasPumas |
| 04 Jul 21 | r03 | Resovia RzeszówResovia Rzesz | 2 - 1 | Hapoel Beer ShevaHapoel Beer S |
| 04 Jul 21 | r03 | Rukh LvivRukh Lviv | 2 - 1 | VolynVolyn |
| 04 Jul 21 | r03 | Envigado F.C.Envigado F.C. | 2 - 0 | Jaguares de CórdobaJaguares de C |
| 04 Jul 21 | r03 | Hebar PazardzhikHebar Pazardz | 0 - 3 | Botev VratsaBotev Vratsa |
| 04 Jul 21 | r03 | PaderbornPaderborn | 2 - 4 | Dortmund IIDortmund II |
| 04 Jul 21 | r03 | HelsingborgHelsingborg | - | Fremad AmagerFremad Amager |
| 04 Jul 21 | r03 | FC Yenisey KrasnoyarskFC Yenisey Kr | 0 - 0 | Metallurg LipetskMetallurg Lip |
| 04 Jul 21 | r03 | KaiserslauternKaiserslauter | 1 - 1 | UnterhachingUnterhaching |
| 04 Jul 21 | r03 | SKN St. PoltenSKN St. Polte | 1 - 2 | FC VoluntariFC Voluntari |
| 04 Jul 21 | r03 | Fortuna DüsseldorfFortuna Düsse | - | Wuerzburger KickersWuerzburger K |
| 04 Jul 21 | r03 | ArisAris | 1 - 3 | Hajduk SplitHajduk Split |
| 04 Jul 21 | r03 | Partizan BelgradePartizan Belg | 3 - 0 | Cracovia KrakowCracovia Krak |
| 04 Jul 21 | r03 | TuS DassendorfTuS Dassendor | 2 - 6 | Holstein Kiel IIHolstein Kiel |
| 04 Jul 21 | r03 | ClitheroeClitheroe | 0 - 3 | AccringtonAccrington |
| 04 Jul 21 | r03 | Werder BremenWerder Bremen | 1 - 0 | CSKA SofiaCSKA Sofia |
| 04 Jul 21 | r03 | SlobodaSloboda | 1 - 1 | Novi PazarNovi Pazar |
| 04 Jul 21 | r03 | Rakow CzestochowaRakow Czestoc | 2 - 1 | Shakhtar DonetskShakhtar Done |
| 04 Jul 21 | r03 | Austria ViennaAustria Vienn | - | FC AshdodFC Ashdod |
| 04 Jul 21 | r03 | Olimpija LjubljanaOlimpija Ljub | 1 - 2 | CukarickiCukaricki |
| 04 Jul 21 | r03 | BastiaBastia | 1 - 0 | FC Bastia-BorgoFC Bastia-Bor |
| 04 Jul 21 | r03 | TSC Bačka TopolaTSC Bačka Top | 2 - 4 | Tuzla CityTuzla City |
| 05 Jul 21 | r03 | Patriotas BoyacáPatriotas Boy | 1 - 3 | Once CaldasOnce Caldas |
| 05 Jul 21 | r03 | Rio Grande ValleyRio Grande Va | 1 - 5 | MonterreyMonterrey |
| 05 Jul 21 | r03 | FC LvivFC Lviv | 1 - 2 | PrykarpattiaPrykarpattia |
| 05 Jul 21 | r03 | EsbjergEsbjerg | 5 - 2 | HOBROHOBRO |
| 05 Jul 21 | r03 | FC Yenisey KrasnoyarskFC Yenisey Kr | 2 - 2 | FC TverFC Tver |
| 05 Jul 21 | r03 | FC UfaFC Ufa | 1 - 3 | Sepsi OSK Sfântu GheorgheSepsi OSK Sfâ |
| 05 Jul 21 | r03 | Cracovia KrakowCracovia Krak | 2 - 2 | Lok. MoscowLok. Moscow |
| 05 Jul 21 | r03 | AEL LimassolAEL Limassol | 0 - 0 | FC VoluntariFC Voluntari |
| 05 Jul 21 | r03 | PartickPartick | 0 - 1 | RangersRangers |
| 05 Jul 21 | r03 | HelsingborgHelsingborg | 2 - 1 | FC HelsingoerFC Helsingoer |
| 05 Jul 21 | r03 | Triglav KranjTriglav Kranj | 2 - 3 | FC AshdodFC Ashdod |
| 05 Jul 21 | r03 | LivingstonLivingston | 4 - 0 | ArbroathArbroath |
| 05 Jul 21 | r03 | SantosSantos | 0 - 1 | CF AmericaCF America |
| 05 Jul 21 | r03 | Spartak MoscowSpartak Mosco | 4 - 2 | ŠibenikŠibenik |
| 05 Jul 21 | r03 | FK Rubin KazanFK Rubin Kaza | - | Ural S.RUral S.R |
| 05 Jul 21 | r03 | Türkgücü MünchenTürkgücü Münc | 1 - 2 | Shakhtar DonetskShakhtar Done |
| 05 Jul 21 | r03 | Crvena ZvezdaCrvena Zvezda | 3 - 0 | Arges PitestiArges Pitesti |
| 05 Jul 21 | r03 | CSKA MoscowCSKA Moscow | 0 - 1 | FC CopenhagenFC Copenhagen |
| 06 Jul 21 | r03 | BeroeBeroe | - | Hebar PazardzhikHebar Pazardz |
| 06 Jul 21 | r03 | Radnik SurdulicaRadnik Surdul | - | SlobodaSloboda |
| 06 Jul 21 | r03 | Santa ClaraSanta Clara | 0 - 0 | FeirenseFeirense |
| 06 Jul 21 | r03 | VorsklaVorskla | 4 - 0 | KarpatyKarpaty |
| 06 Jul 21 | r03 | PardubicePardubice | 3 - 1 | Viktoria ŽižkovViktoria Žižk |
| 06 Jul 21 | r03 | KortrijkKortrijk | 0 - 1 | ValenciennesValenciennes |
| 06 Jul 21 | r03 | AccringtonAccrington | 1 - 0 | HibernianHibernian |
| 06 Jul 21 | r03 | St. GilloiseSt. Gilloise | 6 - 2 | KMSK DeinzeKMSK Deinze |
| 06 Jul 21 | r03 | WolfsburgWolfsburg | 2 - 1 | AueAue |
| 06 Jul 21 | r03 | MontanaMontana | 2 - 1 | Academica ClinceniAcademica Cli |
| 06 Jul 21 | r03 | Lechia GdańskLechia Gdańsk | 2 - 0 | Stomil OlsztynStomil Olszty |
| 06 Jul 21 | r03 | Apollon LimassolApollon Limas | - | FC HeidenheimFC Heidenheim |
| 06 Jul 21 | r03 | Botev VratsaBotev Vratsa | 0 - 2 | BeroeBeroe |
| 06 Jul 21 | r03 | CSKA 1948CSKA 1948 | 1 - 1 | InhuletsInhulets |
| 06 Jul 21 | r03 | FC HeidenheimFC Heidenheim | 4 - 2 | SV Josko RiedSV Josko Ried |
| 06 Jul 21 | r03 | NK BravoNK Bravo | 1 - 1 | MTK HungariaMTK Hungaria |
| 06 Jul 21 | r03 | VizelaVizela | 3 - 4 | BragaBraga |
| 06 Jul 21 | r03 | SandhausenSandhausen | 1 - 0 | FC BotoșaniFC Botoșani |
| 06 Jul 21 | r03 | DijonDijon | 1 - 1 | GrenobleGrenoble |
| 06 Jul 21 | r03 | SC FarenseSC Farense | 0 - 1 | VarzimVarzim |
| 06 Jul 21 | r03 | OpatijaOpatija | 0 - 0 | NK Istra 1961NK Istra 1961 |
| 06 Jul 21 | r03 | AFC FyldeAFC Fylde | - | BarnsleyBarnsley |
| 06 Jul 21 | r03 | Cumbernauld ColtsCumbernauld C | 0 - 2 | MortonMorton |
| 06 Jul 21 | r03 | CS MioveniCS Mioveni | 3 - 2 | SlatinaSlatina |
| 06 Jul 21 | r03 | Jagiellonia BialystokJagiellonia B | 1 - 4 | Radomiak RadomRadomiak Rado |
| 06 Jul 21 | r03 | Arsenal TulaArsenal Tula | 1 - 4 | Sparta PragueSparta Prague |
| 06 Jul 21 | r03 | Austria KlagenfurtAustria Klage | 1 - 2 | Munich 1860Munich 1860 |
| 06 Jul 21 | r03 | FC BaselFC Basel | 1 - 0 | GrasshoppersGrasshoppers |
| 06 Jul 21 | r03 | JablonecJablonec | - | PardubicePardubice |
| 06 Jul 21 | r03 | Gornik ZabrzeGornik Zabrze | 3 - 4 | Omonia NicosiaOmonia Nicosi |
| 06 Jul 21 | r03 | Dundee FCDundee FC | 3 - 0 | Leyton OrientLeyton Orient |
| 06 Jul 21 | r03 | Young BoysYoung Boys | 0 - 1 | SC Rheindorf AltachSC Rheindorf |
| 06 Jul 21 | r03 | HSC 21HSC 21 | 0 - 2 | FC TwenteFC Twente |
| 06 Jul 21 | r03 | SV VenraySV Venray | 0 - 4 | VVV-VenloVVV-Venlo |
| 06 Jul 21 | r03 | LuckenwaldeLuckenwalde | 0 - 1 | Hertha ZehlendorfHertha Zehlen |
| 06 Jul 21 | r03 | AylesburyAylesbury | - | AFC FyldeAFC Fylde |
| 06 Jul 21 | r03 | Walton CasualsWalton Casual | 0 - 3 | CrawleyCrawley |
| 07 Jul 21 | r03 | GenkGenk | 2 - 0 | EupenEupen |
| 07 Jul 21 | r03 | Banik OstravaBanik Ostrava | - | SFC OpavaSFC Opava |
| 07 Jul 21 | r03 | FC Lausanne-SportFC Lausanne-S | - | ValenciennesValenciennes |
| 07 Jul 21 | r03 | MornarMornar | 0 - 0 | Mladost LučaniMladost Lučan |
| 07 Jul 21 | r03 | Universitatea CraiovaUniversitatea | - | Zalaegerszegi TEZalaegerszegi |
| 07 Jul 21 | r03 | Envigado F.C.Envigado F.C. | 0 - 2 | Atlético NacionalAtlético Naci |
| 07 Jul 21 | r03 | Gil VicenteGil Vicente | 1 - 1 | LeixoesLeixoes |
| 07 Jul 21 | r03 | Independiente Santa FeIndependiente | 3 - 1 | Once CaldasOnce Caldas |
| 07 Jul 21 | r03 | BenficaBenfica | 2 - 0 | CovilhaCovilha |
| 07 Jul 21 | r03 | San AntonioSan Antonio | 2 - 4 | Queretaro FCQueretaro FC |
| 07 Jul 21 | r03 | Pirin BlagoevgradPirin Blagoev | 1 - 0 | Spartak VarnaSpartak Varna |
| 07 Jul 21 | r03 | GyirmótGyirmót | 1 - 0 | Szombathelyi HaladásSzombathelyi |
| 07 Jul 21 | r03 | JablonecJablonec | 1 - 1 | Sparta Prague BSparta Prague |
| 07 Jul 21 | r03 | Gornik ZabrzeGornik Zabrze | 0 - 3 | Hapoel Beer ShevaHapoel Beer S |
| 07 Jul 21 | r03 | QPRQPR | 2 - 1 | PortsmouthPortsmouth |
| 07 Jul 21 | r03 | Wehen WiesbadenWehen Wiesbad | 1 - 0 | FC SchweinfurtFC Schweinfur |
| 07 Jul 21 | r03 | Kispest HonvedKispest Honve | 1 - 1 | ŠKF SereďŠKF Sereď |
| 07 Jul 21 | r03 | Lucerne Lucerne | 3 - 3 | Dynamo KievDynamo Kiev |
| 07 Jul 21 | r03 | FC Kolos KovalivkaFC Kolos Kova | 2 - 0 | FC OlexandriaFC Olexandria |
| 07 Jul 21 | r03 | Hansa RostockHansa Rostock | 4 - 3 | Viktoria BerlinViktoria Berl |
| 07 Jul 21 | r03 | Steaua BucurestiSteaua Bucure | 1 - 0 | CS MioveniCS Mioveni |
| 07 Jul 21 | r03 | Chindia TârgovișteChindia Târgo | 0 - 0 | CsikszeredaCsikszereda |
| 07 Jul 21 | r03 | Levski Sofia Levski Sofia | 4 - 0 | Lokomotiv SofiaLokomotiv Sof |
| 07 Jul 21 | r03 | Veres RivneVeres Rivne | 0 - 1 | AhrobiznesAhrobiznes |
| 07 Jul 21 | r03 | TolucaToluca | 0 - 1 | FC JuarezFC Juarez |
| 07 Jul 21 | r03 | Rapid ViennaRapid Vienna | 2 - 2 | SKN St. PoltenSKN St. Polte |
| 07 Jul 21 | r03 | LensLens | 1 - 1 | StandardStandard |
| 07 Jul 21 | r03 | LíšeňLíšeň | 2 - 1 | FK Senica FK Senica |
| 07 Jul 21 | r03 | Hapoel Beer ShevaHapoel Beer S | - | Omonia NicosiaOmonia Nicosi |
| 07 Jul 21 | r03 | Club BruggeClub Brugge | 2 - 1 | WaregemWaregem |
| 07 Jul 21 | r03 | Uta AradUta Arad | - | Zalaegerszegi TEZalaegerszegi |
| 07 Jul 21 | r03 | Beerschot VABeerschot VA | 2 - 0 | Waasland-BeverenWaasland-Beve |
| 07 Jul 21 | r03 | Austria ViennaAustria Vienn | 2 - 1 | Tuzla CityTuzla City |
| 07 Jul 21 | r03 | CSKA SofiaCSKA Sofia | 0 - 1 | Qarabag FKQarabag FK |
| 07 Jul 21 | r03 | Tabor SežanaTabor Sežana | 4 - 1 | Zalaegerszegi TEZalaegerszegi |
| 07 Jul 21 | r03 | AuxerreAuxerre | 3 - 1 | CreteilCreteil |
| 07 Jul 21 | r03 | CaenCaen | 1 - 1 | GuingampGuingamp |
| 07 Jul 21 | r03 | AZ AlkmaarAZ Alkmaar | 3 - 0 | TOP OssTOP Oss |
| 07 Jul 21 | r03 | HNK GoricaHNK Gorica | 1 - 3 | NK LokomotivaNK Lokomotiva |
| 07 Jul 21 | r03 | ArisAris | 2 - 1 | Lok. MoscowLok. Moscow |
| 07 Jul 21 | r03 | CeljeCelje | 3 - 0 | Hajduk SplitHajduk Split |
| 07 Jul 21 | r03 | GuimaraesGuimaraes | 2 - 1 | Sporting BSporting B |
| 07 Jul 21 | r03 | JastrzębieJastrzębie | 1 - 1 | Ruch ChorzowRuch Chorzow |
| 07 Jul 21 | r03 | Zaglebie LubinZaglebie Lubi | 1 - 1 | Miedz LegnicaMiedz Legnica |
| 07 Jul 21 | r03 | VlašimVlašim | 3 - 2 | TepliceTeplice |
| 07 Jul 21 | r03 | Zaglebie SosnowiecZaglebie Sosn | 1 - 3 | KarvinaKarvina |
| 07 Jul 21 | r03 | MornarMornar | 4 - 1 | Novi PazarNovi Pazar |
| 07 Jul 21 | r03 | Wisla PlockWisla Plock | 0 - 2 | Widzew LodzWidzew Lodz |
| 07 Jul 21 | r03 | Odense BKOdense BK | 1 - 1 | BrøndbyBrøndby |
| 07 Jul 21 | r03 | AugsburgAugsburg | 2 - 2 | HamburgHamburg |
| 07 Jul 21 | r03 | Sigma OlomoucSigma Olomouc | 2 - 0 | Tatran Liptovský MikulášTatran Liptov |
| 07 Jul 21 | r03 | Puszcza NiepołomicePuszcza Niepo | 2 - 3 | Wisla KrakowWisla Krakow |
| 07 Jul 21 | r03 | Lech PoznanLech Poznan | 3 - 2 | FC MidtjyllandFC Midtjyllan |
| 07 Jul 21 | r03 | WSG Swarovski TirolWSG Swarovski | 3 - 3 | Rakow CzestochowaRakow Czestoc |
| 07 Jul 21 | r03 | Paksi FCPaksi FC | 5 - 0 | BudaörsBudaörs |
| 07 Jul 21 | r03 | Tsarsko SeloTsarsko Selo | 4 - 0 | Litex LovechLitex Lovech |
| 07 Jul 21 | r03 | Mlada BoleslavMlada Bolesla | 5 - 0 | TrencinTrencin |
| 07 Jul 21 | r03 | Yverdon SportYverdon Sport | 1 - 0 | ServetteServette |
| 07 Jul 21 | r03 | Arda KardzhaliArda Kardzhal | 1 - 0 | CSKA 1948CSKA 1948 |
| 07 Jul 21 | r03 | FC SionFC Sion | 1 - 3 | FC Lausanne-SportFC Lausanne-S |
| 07 Jul 21 | r03 | CharleroiCharleroi | 3 - 3 | AmiensAmiens |
| 07 Jul 21 | r03 | QuevillyQuevilly | 0 - 1 | Le HavreLe Havre |
| 07 Jul 21 | r03 | St.TruidenSt.Truiden | 1 - 0 | MolenbeekMolenbeek |
| 07 Jul 21 | r03 | Union FürstenwaldeUnion Fürsten | 0 - 1 | Tennis Borussia BerlinTennis Boruss |
| 07 Jul 21 | r03 | TSV HartbergTSV Hartberg | - | SV KapfenbergSV Kapfenberg |
| 07 Jul 21 | r03 | Berliner FC DynamoBerliner FC D | 3 - 1 | Lichtenberg 47Lichtenberg 4 |
| 07 Jul 21 | r03 | Wacker InnsbruckWacker Innsbr | - | KarlsruheKarlsruhe |
| 07 Jul 21 | r03 | Werder BremenWerder Bremen | 2 - 2 | Zenit St PetersburgZenit St Pete |
| 07 Jul 21 | r03 | LavalLaval | 1 - 2 | AjaccioAjaccio |
| 07 Jul 21 | r03 | CukarickiCukaricki | 1 - 1 | FC AshdodFC Ashdod |
| 08 Jul 21 | r03 | TigresTigres | 0 - 0 | CD GuadalajaraCD Guadalajar |
| 08 Jul 21 | r03 | SlovackoSlovacko | - | Arges PitestiArges Pitesti |
| 08 Jul 21 | r03 | Santa ClaraSanta Clara | - | FamalicaoFamalicao |
| 08 Jul 21 | r03 | PachucaPachuca | 1 - 2 | Cruz AzulCruz Azul |
| 08 Jul 21 | r03 | CF AmericaCF America | 1 - 0 | AtlasAtlas |
| 08 Jul 21 | r03 | Uta AradUta Arad | 0 - 1 | Hajduk SplitHajduk Split |
| 08 Jul 21 | r03 | AberdeenAberdeen | 1 - 1 | Inverness CInverness C |
| 08 Jul 21 | r03 | MagdeburgMagdeburg | 1 - 1 | VSG AltglienickeVSG Altglieni |
| 08 Jul 21 | r03 | Kisvárda FCKisvárda FC | 2 - 2 | Arges PitestiArges Pitesti |
| 08 Jul 21 | r03 | ZwickauZwickau | 2 - 1 | Carl Zeiss JenaCarl Zeiss Je |
| 08 Jul 21 | r03 | InhuletsInhulets | 1 - 0 | Academica ClinceniAcademica Cli |
| 08 Jul 21 | r03 | ZoryaZorya | 2 - 1 | Proleter Novi SadProleter Novi |
| 08 Jul 21 | r03 | Viktoria PlzenViktoria Plze | 1 - 1 | Sepsi OSK Sfântu GheorgheSepsi OSK Sfâ |
| 08 Jul 21 | r03 | Sturm GrazSturm Graz | 0 - 1 | Cracovia KrakowCracovia Krak |
| 08 Jul 21 | r03 | CsikszeredaCsikszereda | 2 - 3 | Gaz Metan MediașGaz Metan Med |
| 08 Jul 21 | r03 | Anorthosis FamagustaAnorthosis Fa | - | Doxa KatokopiasDoxa Katokopi |
| 08 Jul 21 | r03 | Universitatea CraiovaUniversitatea | 0 - 0 | Radnički NišRadnički Niš |
| 08 Jul 21 | r03 | MoreliaMorelia | 2 - 3 | Tepatitlán FCTepatitlán FC |
| 08 Jul 21 | r03 | Fortuna DüsseldorfFortuna Düsse | 2 - 2 | AEL LimassolAEL Limassol |
| 08 Jul 21 | r03 | Partizan BelgradePartizan Belg | 1 - 0 | FK RostovFK Rostov |
| 08 Jul 21 | r03 | Casa PiaCasa Pia | 2 - 0 | SønderjyskeSønderjyske |
| 08 Jul 21 | r03 | Mlada BoleslavMlada Bolesla | 4 - 0 | Ústí nad LabemÚstí nad Labe |
| 08 Jul 21 | r03 | PEC ZwollePEC Zwolle | 0 - 2 | FC VolendamFC Volendam |
| 08 Jul 21 | r03 | Sturm GrazSturm Graz | - | FK RostovFK Rostov |
| 08 Jul 21 | r03 | LuganoLugano | 0 - 0 | FC WinterthurFC Winterthur |
| 08 Jul 21 | r03 | Triglav KranjTriglav Kranj | 1 - 3 | RijekaRijeka |
| 08 Jul 21 | r03 | AnnecyAnnecy | 2 - 3 | BastiaBastia |
| 08 Jul 21 | r03 | Sturm GrazSturm Graz | 1 - 1 | Crvena ZvezdaCrvena Zvezda |
| 09 Jul 21 | r03 | Korona KielceKorona Kielce | - | NiecieczaNieciecza |
| 09 Jul 21 | r03 | La EquidadLa Equidad | 0 - 1 | Once CaldasOnce Caldas |
| 09 Jul 21 | r03 | Queretaro FCQueretaro FC | 1 - 2 | Real EspañaReal España |
| 09 Jul 21 | r03 | PetrolulPetrolul | 0 - 0 | Chindia TârgovișteChindia Târgo |
| 09 Jul 21 | r03 | SKU AmstettenSKU Amstetten | 5 - 2 | AEL LimassolAEL Limassol |
| 09 Jul 21 | r03 | GyirmótGyirmót | 0 - 0 | SzolnokSzolnok |
| 09 Jul 21 | r03 | Lechia GdańskLechia Gdańsk | 0 - 2 | Radomiak RadomRadomiak Rado |
| 09 Jul 21 | r03 | StokeStoke | 1 - 1 | HibernianHibernian |
| 09 Jul 21 | r03 | FC UtrechtFC Utrecht | 3 - 0 | GentGent |
| 09 Jul 21 | r03 | LandskronaLandskrona | 1 - 1 | B.93B.93 |
| 09 Jul 21 | r03 | LensLens | 0 - 1 | St. GilloiseSt. Gilloise |
| 09 Jul 21 | r03 | Jong UtrechtJong Utrecht | 3 - 0 | Almere City FCAlmere City F |
| 09 Jul 21 | r03 | MainzMainz | 2 - 1 | Wuerzburger KickersWuerzburger K |
| 09 Jul 21 | r03 | SPVGG Greuther FürthSPVGG Greuthe | 0 - 1 | Bayern Munich IIBayern Munich |
| 09 Jul 21 | r03 | UniversitarioUniversitario | 0 - 0 | Universidad de San MartínUniversidad d |
| 09 Jul 21 | r03 | Cracovia KrakowCracovia Krak | 0 - 1 | SlovackoSlovacko |
| 09 Jul 21 | r03 | LorientLorient | 0 - 0 | ConcarneauConcarneau |
| 09 Jul 21 | r03 | VizelaVizela | 1 - 2 | F.C. Paços de FerreiraF.C. Paços de |
| 09 Jul 21 | r03 | Fortuna KölnFortuna Köln | 0 - 4 | FC KolnFC Koln |
| 09 Jul 21 | r03 | Vejle BoldklubVejle Boldklu | 5 - 1 | EsbjergEsbjerg |
| 09 Jul 21 | r03 | FC UfaFC Ufa | 2 - 1 | FC BotoșaniFC Botoșani |
| 09 Jul 21 | r03 | VarzimVarzim | 0 - 1 | Estrela AmadoraEstrela Amado |
| 09 Jul 21 | r03 | Waasland-BeverenWaasland-Beve | 0 - 2 | LilleLille |
| 09 Jul 21 | r03 | SCM Gloria BuzăuSCM Gloria Bu | 1 - 5 | Steaua BucurestiSteaua Bucure |
| 09 Jul 21 | r03 | DijonDijon | 1 - 2 | NancyNancy |
| 09 Jul 21 | r03 | Stafford RangersStafford Rang | 2 - 0 | Port ValePort Vale |
| 09 Jul 21 | r03 | SønderjyskeSønderjyske | - | BragaBraga |
| 09 Jul 21 | r03 | CSKA 1948CSKA 1948 | 2 - 1 | Lokomotiv Plovdiv Lokomotiv Plo |
| 09 Jul 21 | r03 | Mladost LučaniMladost Lučan | 0 - 3 | Radnik SurdulicaRadnik Surdul |
| 09 Jul 21 | r03 | Jagiellonia BialystokJagiellonia B | 1 - 1 | Wigry SuwałkiWigry Suwałki |
| 09 Jul 21 | r03 | MechelenMechelen | 2 - 2 | Roda JCRoda JC |
| 09 Jul 21 | r03 | AaBAaB | 1 - 0 | AGF AarhusAGF Aarhus |
| 09 Jul 21 | r03 | Dundee FCDundee FC | 2 - 2 | West HamWest Ham |
| 09 Jul 21 | r03 | Osters IFOsters IF | 2 - 2 | GaisGais |
| 09 Jul 21 | r03 | Lech PoznanLech Poznan | 0 - 2 | Arka GdyniaArka Gdynia |
| 09 Jul 21 | r03 | RijekaRijeka | 4 - 3 | MTK HungariaMTK Hungaria |
| 09 Jul 21 | r03 | FC BW LinzFC BW Linz | 1 - 1 | LiberecLiberec |
| 09 Jul 21 | r03 | Wolfsberger ACWolfsberger A | 3 - 2 | Sparta PragueSparta Prague |
| 09 Jul 21 | r03 | FC Trenkwalder AdmiraFC Trenkwalde | 0 - 1 | CSKA MoscowCSKA Moscow |
| 09 Jul 21 | r03 | DAC 1904 Dunajská StredaDAC 1904 Duna | 2 - 1 | VasasVasas |
| 09 Jul 21 | r03 | Club BruggeClub Brugge | 2 - 1 | AEKAEK |
| 09 Jul 21 | r03 | Austria KlagenfurtAustria Klage | 2 - 2 | SV LafnitzSV Lafnitz |
| 09 Jul 21 | r03 | SV Josko RiedSV Josko Ried | 0 - 2 | Jahn RegensburgJahn Regensbu |
| 09 Jul 21 | r03 | TSV HartbergTSV Hartberg | 0 - 1 | Lok. MoscowLok. Moscow |
| 09 Jul 21 | r03 | SV HornSV Horn | - | FC CopenhagenFC Copenhagen |
| 09 Jul 21 | r03 | Shakhtar DonetskShakhtar Done | 0 - 0 | Schalke 04Schalke 04 |
| 09 Jul 21 | r03 | SC Rheindorf AltachSC Rheindorf | 4 - 1 | DornbirnDornbirn |
| 09 Jul 21 | r03 | Schwarz-Weiß RehdenSchwarz-Weiß | 1 - 3 | RödinghausenRödinghausen |
| 09 Jul 21 | r03 | StrasbourgStrasbourg | 0 - 1 | FC BaselFC Basel |
| 09 Jul 21 | r03 | PAOKPAOK | 3 - 1 | NFC VolosNFC Volos |
| 09 Jul 21 | r03 | FC GroningenFC Groningen | - | FC EmmenFC Emmen |
| 09 Jul 21 | r03 | VVV-VenloVVV-Venlo | 2 - 0 | VV UNAVV UNA |
| 09 Jul 21 | r03 | Chesham UnitedChesham Unite | - | WycombeWycombe |
| 09 Jul 21 | r03 | Tiverton TownTiverton Town | 0 - 1 | ExeterExeter |
| 09 Jul 21 | r03 | Squires GateSquires Gate | 0 - 7 | BlackpoolBlackpool |
| 10 Jul 21 | r03 | Ein FrankfurtEin Frankfurt | 1 - 3 | Wehen WiesbadenWehen Wiesbad |
| 10 Jul 21 | r03 | Wisla PlockWisla Plock | - | Radomiak RadomRadomiak Rado |
| 10 Jul 21 | r03 | ValenciennesValenciennes | - | BastiaBastia |
| 10 Jul 21 | r03 | SC TelstarSC Telstar | - | Jong AjaxJong Ajax |
| 10 Jul 21 | r03 | SC CambuurSC Cambuur | - | FC TwenteFC Twente |
| 10 Jul 21 | r03 | CS MioveniCS Mioveni | - | PetrolulPetrolul |
| 10 Jul 21 | r03 | Atlético NacionalAtlético Naci | - | ValleduparValledupar |
| 10 Jul 21 | r03 | Cusco FCCusco FC | - | Academia Deportiva CantolAcademia Depo |
| 10 Jul 21 | r03 | Alianza UniversidadAlianza Unive | - | FBC MelgarFBC Melgar |
| 10 Jul 21 | r03 | CiencianoCienciano | - | CC Deportivo MunicipalCC Deportivo |
| 10 Jul 21 | r03 | San AntonioSan Antonio | 2 - 4 | PumasPumas |
| 10 Jul 21 | r03 | Arda KardzhaliArda Kardzhal | 0 - 1 | Slavia SofiaSlavia Sofia |
| 10 Jul 21 | r03 | MonacoMonaco | 3 - 1 | Cercle BruggeCercle Brugge |
| 10 Jul 21 | r03 | Levski Sofia Levski Sofia | - | Pirin BlagoevgradPirin Blagoev |
| 10 Jul 21 | r03 | MoreirenseMoreirense | 0 - 4 | BragaBraga |
| 10 Jul 21 | r03 | Banik OstravaBanik Ostrava | 2 - 0 | LíšeňLíšeň |
| 10 Jul 21 | r03 | Levski Sofia Levski Sofia | 1 - 1 | Levski LomLevski Lom |
| 10 Jul 21 | r03 | CS MioveniCS Mioveni | 2 - 1 | Astra Astra |
| 10 Jul 21 | r03 | FC Kolos KovalivkaFC Kolos Kova | 1 - 0 | AvanhardAvanhard |
| 10 Jul 21 | r03 | ZlínZlín | 2 - 2 | ProstějovProstějov |
| 10 Jul 21 | r03 | TepliceTeplice | 2 - 2 | TáborskoTáborsko |
| 10 Jul 21 | r03 | Stade Lausanne OuchyStade Lausann | 0 - 3 | Yverdon SportYverdon Sport |
| 10 Jul 21 | r03 | Silkeborg IFSilkeborg IF | 5 - 1 | Hvidovre IFHvidovre IF |
| 10 Jul 21 | r03 | SiófokSiófok | - | Zalaegerszegi TEZalaegerszegi |
| 10 Jul 21 | r03 | FC LieferingFC Liefering | 4 - 0 | GrödigGrödig |
| 10 Jul 21 | r03 | VlašimVlašim | 1 - 3 | Dynamo České BudějoviceDynamo České |
| 10 Jul 21 | r03 | Odra OpoleOdra Opole | 0 - 0 | Ruch ChorzowRuch Chorzow |
| 10 Jul 21 | r03 | Wisla PlockWisla Plock | 3 - 0 | Skra CzęstochowaSkra Częstoch |
| 10 Jul 21 | r03 | KøgeKøge | 3 - 0 | NykøbingNykøbing |
| 10 Jul 21 | r03 | GuimaraesGuimaraes | 2 - 1 | MafraMafra |
| 10 Jul 21 | r03 | GKS KatowiceGKS Katowice | 1 - 0 | Sandecja Nowy SaczSandecja Nowy |
| 10 Jul 21 | r03 | MVV MaastrichtMVV Maastrich | - | Fortuna SittardFortuna Sitta |
| 10 Jul 21 | r03 | Korona KielceKorona Kielce | 2 - 0 | Widzew LodzWidzew Lodz |
| 10 Jul 21 | r03 | Górnik PolkowiceGórnik Polkow | 0 - 0 | Slask WroclawSlask Wroclaw |
| 10 Jul 21 | r03 | Gil VicenteGil Vicente | 2 - 1 | Santa ClaraSanta Clara |
| 10 Jul 21 | r03 | TondelaTondela | - | AroucaArouca |
| 10 Jul 21 | r03 | HOBROHOBRO | 2 - 0 | Aarhus FremadAarhus Fremad |
| 10 Jul 21 | r03 | ZwickauZwickau | 2 - 0 | ZFC MeuselwitzZFC Meuselwit |
| 10 Jul 21 | r03 | Holstein KielHolstein Kiel | 1 - 1 | BrøndbyBrøndby |
| 10 Jul 21 | r03 | Fremad AmagerFremad Amager | 3 - 2 | Hellerup IKHellerup IK |
| 10 Jul 21 | r03 | LyngbyLyngby | 4 - 4 | FC HelsingoerFC Helsingoer |
| 10 Jul 21 | r03 | TranmereTranmere | 1 - 0 | RangersRangers |
| 10 Jul 21 | r03 | TSV HavelseTSV Havelse | 3 - 2 | Rot Weiss AhlenRot Weiss Ahl |
| 10 Jul 21 | r03 | Chojniczanka ChojniceChojniczanka | 3 - 1 | Stomil OlsztynStomil Olszty |
| 10 Jul 21 | r03 | VSG AltglienickeVSG Altglieni | - | Viktoria BerlinViktoria Berl |
| 10 Jul 21 | r03 | MotherwellMotherwell | 0 - 2 | MillwallMillwall |
| 10 Jul 21 | r03 | Phönix LübeckPhönix Lübeck | 1 - 0 | Tennis Borussia BerlinTennis Boruss |
| 10 Jul 21 | r03 | ReadingReading | 1 - 0 | LincolnLincoln |
| 10 Jul 21 | r03 | SpartaSparta | 3 - 3 | GentGent |
| 10 Jul 21 | r03 | Germania HalberstadtGermania Halb | - | HannoverHannover |
| 10 Jul 21 | r03 | Hannoverscher SCHannoverscher | 2 - 1 | Germania HalberstadtGermania Halb |
| 10 Jul 21 | r03 | Berliner AK 07Berliner AK 0 | 0 - 2 | Hallescher FCHallescher FC |
| 10 Jul 21 | r03 | TSV AubstadtTSV Aubstadt | 2 - 1 | FC EilenburgFC Eilenburg |
| 10 Jul 21 | r03 | Jong PSVJong PSV | 0 - 1 | FC EindhovenFC Eindhoven |
| 10 Jul 21 | r03 | Bognor Regis TownBognor Regis | 0 - 3 | BurtonBurton |
| 10 Jul 21 | r03 | LeixoesLeixoes | 3 - 1 | TrofenseTrofense |
| 10 Jul 21 | r03 | NurnbergNurnberg | 0 - 0 | FC KrasnodarFC Krasnodar |
| 10 Jul 21 | r03 | Waldhof MannheimWaldhof Mannh | - | FolaFola |
| 10 Jul 21 | r03 | TSV Steinbach HaigerTSV Steinbach | 5 - 1 | Bergisch Gladbach 09Bergisch Glad |
| 10 Jul 21 | r03 | GenkGenk | 1 - 1 | FC GroningenFC Groningen |
| 10 Jul 21 | r03 | Amsterdamsche FCAmsterdamsche | 2 - 1 | NEC NijmegenNEC Nijmegen |
| 10 Jul 21 | r03 | SC HeerenveenSC Heerenveen | 2 - 2 | KortrijkKortrijk |
| 10 Jul 21 | r03 | IJsselmeervogelsIJsselmeervog | 1 - 3 | De GraafschapDe Graafschap |
| 10 Jul 21 | r03 | WSG Swarovski TirolWSG Swarovski | 3 - 1 | SandhausenSandhausen |
| 10 Jul 21 | r03 | Oud-Heverlee LeuvenOud-Heverlee | 1 - 0 | ValenciennesValenciennes |
| 10 Jul 21 | r03 | Union BerlinUnion Berlin | - | Dukla PrahaDukla Praha |
| 10 Jul 21 | r03 | NAC BredaNAC Breda | 1 - 0 | Maccabi Tel AvivMaccabi Tel A |
| 10 Jul 21 | r03 | WSG Swarovski TirolWSG Swarovski | - | Nottingham F.Nottingham F. |
| 10 Jul 21 | r03 | WolfsburgWolfsburg | 0 - 3 | Hansa RostockHansa Rostock |
| 10 Jul 21 | r03 | ExcelsiorExcelsior | - | ExcelsiorExcelsior |
| 10 Jul 21 | r03 | FK Rubin KazanFK Rubin Kaza | 1 - 0 | Khimki FKKhimki FK |
| 10 Jul 21 | r03 | GuingampGuingamp | 2 - 2 | BrestBrest |
| 10 Jul 21 | r03 | Chester CityChester City | 0 - 2 | Sheffield WedsSheffield Wed |
| 10 Jul 21 | r03 | VfR GarchingVfR Garching | - | Wacker InnsbruckWacker Innsbr |
| 10 Jul 21 | r03 | NecaxaNecaxa | 0 - 0 | CS HeredianoCS Herediano |
| 10 Jul 21 | r03 | LeonLeon | 2 - 0 | Atletico de San LuisAtletico de S |
| 10 Jul 21 | r03 | Resovia RzeszówResovia Rzesz | 3 - 1 | KosiceKosice |
| 10 Jul 21 | r03 | StandardStandard | 2 - 2 | MechelenMechelen |
| 10 Jul 21 | r03 | DuisburgDuisburg | 1 - 1 | FC KolnFC Koln |
| 10 Jul 21 | r03 | Septemvri SofiaSeptemvri Sof | 0 - 2 | BeroeBeroe |
| 10 Jul 21 | r03 | SC Dnipro-1SC Dnipro-1 | 1 - 1 | FC Kolos KovalivkaFC Kolos Kova |
| 10 Jul 21 | r03 | Beerschot VABeerschot VA | 2 - 1 | Lommel SKLommel SK |
| 10 Jul 21 | r03 | SKN St. PoltenSKN St. Polte | 1 - 0 | Bohemians 1905Bohemians 190 |
| 10 Jul 21 | r03 | Stade de ReimsStade de Reim | 4 - 1 | AuxerreAuxerre |
| 10 Jul 21 | r03 | Radnički 1923Radnički 1923 | 0 - 3 | Metalac GMMetalac GM |
| 10 Jul 21 | r03 | Farul ConstantaFarul Constan | 1 - 1 | Cherno MoreCherno More |
| 10 Jul 21 | r03 | BenficaBenfica | 3 - 2 | SC FarenseSC Farense |
| 10 Jul 21 | r03 | Tabor SežanaTabor Sežana | 2 - 0 | GoricaGorica |
| 10 Jul 21 | r03 | Novi PazarNovi Pazar | 1 - 0 | Rudar PljevljaRudar Pljevlj |
| 10 Jul 21 | r03 | PortimonensePortimonense | 0 - 1 | CovilhaCovilha |
| 10 Jul 21 | r03 | Europa PointEuropa Point | 0 - 3 | Sheffield UnitedSheffield Uni |
| 10 Jul 21 | r03 | SC CambuurSC Cambuur | 6 - 0 | SC TelstarSC Telstar |
| 10 Jul 21 | r03 | MontpellierMontpellier | 2 - 4 | Sète 34Sète 34 |
| 10 Jul 21 | r03 | VojvodinaVojvodina | 0 - 0 | Maccabi Netanya Maccabi Netan |
| 10 Jul 21 | r03 | TigresTigres | 0 - 1 | CF AmericaCF America |
| 10 Jul 21 | r03 | LyonLyon | 5 - 1 | Bourg-PeronnasBourg-Peronna |
| 10 Jul 21 | r03 | CS MioveniCS Mioveni | 3 - 2 | SlatinaSlatina |
| 10 Jul 21 | r03 | Bergerac PérigordBergerac Péri | 0 - 1 | BordeauxBordeaux |
| 10 Jul 21 | r03 | Banik OstravaBanik Ostrava | - | FK Senica FK Senica |
| 10 Jul 21 | r03 | Dukla PrahaDukla Praha | 4 - 2 | VarnsdorfVarnsdorf |
| 10 Jul 21 | r03 | NiceNice | 0 - 3 | FC Lausanne-SportFC Lausanne-S |
| 10 Jul 21 | r03 | Vysočina JihlavaVysočina Jihl | 1 - 2 | Zbrojovka BrnoZbrojovka Brn |
| 10 Jul 21 | r03 | Dynamo České BudějoviceDynamo České | - | TepliceTeplice |
| 10 Jul 21 | r03 | SFC OpavaSFC Opava | 2 - 1 | Tatran Liptovský MikulášTatran Liptov |
| 10 Jul 21 | r03 | Hradec KrálovéHradec Králov | 1 - 0 | PribramPribram |
| 10 Jul 21 | r03 | FC SionFC Sion | 3 - 1 | SochauxSochaux |
| 10 Jul 21 | r03 | Tychy 71Tychy 71 | 3 - 3 | KarvinaKarvina |
| 10 Jul 21 | r03 | Warta PoznańWarta Poznań | 1 - 2 | Gornik ZabrzeGornik Zabrze |
| 10 Jul 21 | r03 | VlašimVlašim | - | TáborskoTáborsko |
| 10 Jul 21 | r03 | ChrudimChrudim | - | Mlada BoleslavMlada Bolesla |
| 10 Jul 21 | r03 | Zaglebie SosnowiecZaglebie Sosn | 1 - 2 | Podbeskidzie Bielsko-BialPodbeskidzie |
| 10 Jul 21 | r03 | AC HorsensAC Horsens | 2 - 0 | Kolding IFKolding IF |
| 10 Jul 21 | r03 | ViborgViborg | - | Randers FCRanders FC |
| 10 Jul 21 | r03 | SC Heracles AlmeloSC Heracles A | - | Go Ahead EaglesGo Ahead Eagl |
| 10 Jul 21 | r03 | BochumBochum | - | SC VerlSC Verl |
| 10 Jul 21 | r03 | IFK VarnamoIFK Varnamo | 0 - 1 | Falkenbergs FFFalkenbergs F |
| 10 Jul 21 | r03 | Huddersfield TownHuddersfield | 1 - 0 | Harrogate Town FCHarrogate Tow |
| 10 Jul 21 | r03 | GrasshoppersGrasshoppers | 0 - 2 | Lucerne Lucerne |
| 10 Jul 21 | r03 | St Pauli IISt Pauli II | 4 - 1 | TuS DassendorfTuS Dassendor |
| 10 Jul 21 | r03 | AC HorsensAC Horsens | - | Aarhus FremadAarhus Fremad |
| 10 Jul 21 | r03 | DartfordDartford | 0 - 1 | IpswichIpswich |
| 10 Jul 21 | r03 | Welling UnitedWelling Unite | 3 - 3 | GillinghamGillingham |
| 10 Jul 21 | r03 | LutonLuton | 4 - 0 | RochdaleRochdale |
| 10 Jul 21 | r03 | LeamingtonLeamington | - | CoventryCoventry |
| 10 Jul 21 | r03 | AueAue | 1 - 2 | MagdeburgMagdeburg |
| 10 Jul 21 | r03 | Chemie LeipzigChemie Leipzi | 2 - 0 | SpVgg Greuther Fürth IISpVgg Greuthe |
| 10 Jul 21 | r03 | Eintracht Norderstedt 03Eintracht Nor | - | Bremer SVBremer SV |
| 10 Jul 21 | r03 | StuttgartStuttgart | 3 - 0 | St. GallenSt. Gallen |
| 10 Jul 21 | r03 | SV SalzburgSV Salzburg | - | Rakow CzestochowaRakow Czestoc |
| 10 Jul 21 | r03 | AmiensAmiens | 2 - 1 | KV OostendeKV Oostende |
| 10 Jul 21 | r03 | Willem IIWillem II | 5 - 2 | Quick BoysQuick Boys |
| 10 Jul 21 | r03 | BielefeldBielefeld | 1 - 0 | HannoverHannover |
| 10 Jul 21 | r03 | FreiburgFreiburg | 2 - 1 | FC SaarbrückenFC Saarbrücke |
| 10 Jul 21 | r03 | VV UNAVV UNA | - | FC EindhovenFC Eindhoven |
| 10 Jul 21 | r03 | WaregemWaregem | 3 - 2 | CharleroiCharleroi |
| 10 Jul 21 | r03 | SchaffhausenSchaffhausen | 1 - 1 | Freiburg IIFreiburg II |
| 10 Jul 21 | r03 | MönchengladbachMönchengladba | 2 - 2 | Viktoria KölnViktoria Köln |
| 10 Jul 21 | r03 | JastrzębieJastrzębie | 0 - 2 | Piast GliwicePiast Gliwice |
| 10 Jul 21 | r03 | Bamber BridgeBamber Bridge | 3 - 8 | PrestonPreston |
| 10 Jul 21 | r03 | AFC FyldeAFC Fylde | 0 - 1 | BlackburnBlackburn |
| 10 Jul 21 | r03 | CaenCaen | 0 - 0 | AjaccioAjaccio |
| 10 Jul 21 | r03 | PardubicePardubice | 2 - 1 | TrencinTrencin |
| 10 Jul 21 | r03 | Atherton CollieriesAtherton Coll | 0 - 3 | Salford CitySalford City |
| 10 Jul 21 | r03 | Hitchin TownHitchin Town | 0 - 1 | StevenageStevenage |
| 10 Jul 21 | r03 | ThunThun | 0 - 1 | Neuchâtel XamaxNeuchâtel Xam |
| 10 Jul 21 | r03 | VaduzVaduz | 0 - 0 | ZurichZurich |
| 10 Jul 21 | r03 | RadcliffeRadcliffe | 0 - 2 | Fleetwood TownFleetwood Tow |
| 10 Jul 21 | r03 | Havant & WaterloovilleHavant & Wate | 2 - 5 | PortsmouthPortsmouth |
| 10 Jul 21 | r03 | St.TruidenSt.Truiden | 2 - 1 | WesterloWesterlo |
| 10 Jul 21 | r03 | Bath CityBath City | 0 - 5 | CardiffCardiff |
| 10 Jul 21 | r03 | AshtonAshton | 1 - 2 | OldhamOldham |
| 10 Jul 21 | r03 | Jahn RegensburgJahn Regensbu | 2 - 2 | Wacker InnsbruckWacker Innsbr |
| 10 Jul 21 | r03 | EupenEupen | 1 - 0 | MolenbeekMolenbeek |
| 10 Jul 21 | r03 | SouthportSouthport | 0 - 2 | BlackpoolBlackpool |
| 10 Jul 21 | r03 | AtlasAtlas | 3 - 0 | DoradosDorados |
| 10 Jul 21 | r03 | MFK RužomberokMFK Ružombero | 2 - 1 | FK PohronieFK Pohronie |
| 10 Jul 21 | r03 | Tsarsko SeloTsarsko Selo | 3 - 2 | Botev PlovdivBotev Plovdiv |
| 10 Jul 21 | r03 | Sigma OlomoucSigma Olomouc | 1 - 2 | FC MidtjyllandFC Midtjyllan |
| 10 Jul 21 | r03 | LASKLASK | 1 - 0 | FC HeidenheimFC Heidenheim |
| 10 Jul 21 | r03 | TroyesTroyes | 2 - 2 | NimesNimes |
| 10 Jul 21 | r03 | RennesRennes | 2 - 2 | Le HavreLe Havre |
| 10 Jul 21 | r03 | Újpest FCÚjpest FC | 1 - 1 | DiosgyorDiosgyor |
| 10 Jul 21 | r03 | Clermont FootClermont Foot | 2 - 2 | Rodez AFRodez AF |
| 10 Jul 21 | r03 | OsijekOsijek | 3 - 0 | TSC Bačka TopolaTSC Bačka Top |
| 10 Jul 21 | r03 | Slaven Belupo KoprivnicaSlaven Belupo | 3 - 1 | NK AluminijNK Aluminij |
| 10 Jul 21 | r03 | Olimpija LjubljanaOlimpija Ljub | 2 - 0 | FC AshdodFC Ashdod |
| 10 Jul 21 | r03 | Rapid ViennaRapid Vienna | 1 - 0 | FC CopenhagenFC Copenhagen |
| 10 Jul 21 | r03 | St EtienneSt Etienne | 2 - 2 | Le Puy Foot 43Le Puy Foot 4 |
| 10 Jul 21 | r03 | FC BaselFC Basel | 3 - 3 | FC AarauFC Aarau |
| 10 Jul 21 | r03 | HNK GoricaHNK Gorica | 0 - 2 | NK BravoNK Bravo |
| 10 Jul 21 | r03 | ServetteServette | 1 - 1 | Dynamo KievDynamo Kiev |
| 11 Jul 21 | r03 | Estrela AmadoraEstrela Amado | 1 - 1 | Benfica BBenfica B |
| 11 Jul 21 | r03 | San Diego LoyalSan Diego Loy | 0 - 1 | TijuanaTijuana |
| 11 Jul 21 | r03 | SantosSantos | 4 - 4 | Tampico MaderoTampico Mader |
| 11 Jul 21 | r03 | Skive IKSkive IK | 1 - 4 | JammerbugtJammerbugt |
| 11 Jul 21 | r03 | Lichtenberg 47Lichtenberg 4 | 1 - 3 | CottbusCottbus |
| 11 Jul 21 | r03 | Munich 1860Munich 1860 | 4 - 2 | Wacker BurghausenWacker Burgha |
| 11 Jul 21 | r03 | Vejle BoldklubVejle Boldklu | 1 - 0 | LübeckLübeck |
| 11 Jul 21 | r03 | Spartak MoscowSpartak Mosco | 4 - 0 | PFC SochiPFC Sochi |
| 11 Jul 21 | r03 | Lok. MoscowLok. Moscow | 1 - 0 | CeljeCelje |
| 11 Jul 21 | r03 | FC U Craiova 1948FC U Craiova | 7 - 0 | PanduriiPandurii |
| 11 Jul 21 | r03 | Paksi FCPaksi FC | 1 - 1 | FC HermannstadtFC Hermannsta |
| 11 Jul 21 | r03 | MarseilleMarseille | 2 - 1 | Sète 34Sète 34 |
| 11 Jul 21 | r03 | NK Istra 1961NK Istra 1961 | 1 - 1 | KoperKoper |
| 11 Jul 21 | r03 | MonterreyMonterrey | 1 - 0 | CD GuadalajaraCD Guadalajar |
| 11 Jul 21 | r03 | VfL OldenburgVfL Oldenburg | 1 - 6 | OberneulandOberneuland |
| 11 Jul 21 | r03 | Ural S.RUral S.R | - | Krylya Sovetov SamaraKrylya Soveto |
| 11 Jul 21 | r03 | Nantwich TownNantwich Town | 1 - 4 | CreweCrewe |
| 11 Jul 21 | r03 | Türkgücü MünchenTürkgücü Münc | 0 - 0 | KarlsruheKarlsruhe |
| 11 Jul 21 | r03 | FC LvivFC Lviv | 1 - 0 | Podillya KhmelnytskyiPodillya Khme |
| 11 Jul 21 | r03 | Chemie LeipzigChemie Leipzi | 0 - 1 | VfV HildesheimVfV Hildeshei |
| 11 Jul 21 | r03 | KarlsruheKarlsruhe | 1 - 3 | Zenit St PetersburgZenit St Pete |
| 11 Jul 21 | r03 | Sigma OlomoucSigma Olomouc | 1 - 1 | Zaglebie LubinZaglebie Lubi |
| 11 Jul 21 | r03 | AngersAngers | 2 - 2 | NiortNiort |
| 11 Jul 21 | r03 | Arsenal TulaArsenal Tula | 1 - 0 | Qarabag FKQarabag FK |
| 12 Jul 21 | r03 | Terek GroznyTerek Grozny | 1 - 3 | Bohemians 1905Bohemians 190 |
| 12 Jul 21 | r03 | Hajduk SplitHajduk Split | 1 - 3 | ZrinjskiZrinjski |
| 12 Jul 21 | r03 | Santa ClaraSanta Clara | 0 - 0 | VarzimVarzim |
| 12 Jul 21 | r03 | Austin BoldAustin Bold | 0 - 1 | Cruz AzulCruz Azul |
| 12 Jul 21 | r03 | FK RostovFK Rostov | 1 - 2 | Lok. MoscowLok. Moscow |
| 12 Jul 21 | r03 | HamburgHamburg | 1 - 0 | Silkeborg IFSilkeborg IF |
| 12 Jul 21 | r03 | Sparta PragueSparta Prague | 2 - 2 | Dinamo MoscowDinamo Moscow |
| 12 Jul 21 | r03 | Terek GroznyTerek Grozny | 1 - 2 | LiberecLiberec |
| 12 Jul 21 | r03 | Apollon LimassolApollon Limas | - | Bohemians 1905Bohemians 190 |
| 12 Jul 21 | r03 | Viktoria PlzenViktoria Plze | 2 - 0 | FC UfaFC Ufa |
| 12 Jul 21 | r03 | GianninaGiannina | - | Gornik LecznaGornik Leczna |
| 12 Jul 21 | r03 | FC Metalist KharkivFC Metalist K | 3 - 1 | Kryvbas Kryvyi RihKryvbas Kryvy |
| 12 Jul 21 | r03 | NyíregyházaNyíregyháza | 0 - 1 | SlovackoSlovacko |
| 12 Jul 21 | r03 | Kisvárda FCKisvárda FC | 2 - 1 | FK RostovFK Rostov |
| 13 Jul 21 | r03 | Austin FCAustin FC | 1 - 3 | TigresTigres |
| 13 Jul 21 | r03 | SC CambuurSC Cambuur | - | FC DordrechtFC Dordrecht |
| 13 Jul 21 | r03 | Metalac GMMetalac GM | - | Pyunik YerevanPyunik Yereva |
| 13 Jul 21 | r03 | Estrela AmadoraEstrela Amado | 0 - 0 | BragaBraga |
| 13 Jul 21 | r03 | BenficaBenfica | 0 - 0 | BelenensesBelenenses |
| 13 Jul 21 | r03 | LilleLille | - | ValenciennesValenciennes |
| 13 Jul 21 | r03 | OberneulandOberneuland | 0 - 12 | Werder BremenWerder Bremen |
| 13 Jul 21 | r03 | Lancaster CityLancaster Cit | - | BarrowBarrow |
| 13 Jul 21 | r03 | Heybridge SwiftsHeybridge Swi | - | AldershotAldershot |
| 13 Jul 21 | r03 | Academico ViseuAcademico Vis | 1 - 1 | AnadiaAnadia |
| 13 Jul 21 | r03 | PumasPumas | 2 - 2 | Queretaro FCQueretaro FC |
| 13 Jul 21 | r03 | Casa PiaCasa Pia | - | VilafranquenseVilafranquens |
| 13 Jul 21 | r03 | Arka GdyniaArka Gdynia | 2 - 1 | Gornik ZabrzeGornik Zabrze |
| 13 Jul 21 | r03 | Yverdon SportYverdon Sport | - | Young BoysYoung Boys |
| 13 Jul 21 | r03 | Fleetwood TownFleetwood Tow | 1 - 0 | Port ValePort Vale |
| 13 Jul 21 | r03 | SC TelstarSC Telstar | 0 - 0 | SpartaSparta |
| 13 Jul 21 | r03 | Joenkoeping S.Joenkoeping S | 5 - 3 | IFK GothenburgIFK Gothenbur |
| 13 Jul 21 | r03 | DuisburgDuisburg | 2 - 3 | Preußen MünsterPreußen Münst |
| 13 Jul 21 | r03 | VorsklaVorskla | 0 - 0 | MynaiMynai |
| 13 Jul 21 | r03 | PardubicePardubice | 0 - 2 | Vysočina JihlavaVysočina Jihl |
| 13 Jul 21 | r03 | MetzMetz | 3 - 2 | NancyNancy |
| 13 Jul 21 | r03 | Lechia GdańskLechia Gdańsk | 0 - 0 | Chojniczanka ChojniceChojniczanka |
| 13 Jul 21 | r03 | Club BruggeClub Brugge | 2 - 4 | FC UtrechtFC Utrecht |
| 13 Jul 21 | r03 | Szombathelyi HaladásSzombathelyi | 4 - 1 | Rapid Wien IIRapid Wien II |
| 13 Jul 21 | r03 | CSKA MoscowCSKA Moscow | 2 - 0 | ViOn Zlaté MoravceViOn Zlaté Mo |
| 13 Jul 21 | r03 | VitesseVitesse | 2 - 1 | OFIOFI |
| 13 Jul 21 | r03 | FredericiaFredericia | 4 - 1 | MiddelfartMiddelfart |
| 13 Jul 21 | r03 | SC HeerenveenSC Heerenveen | 0 - 2 | Maccabi Tel AvivMaccabi Tel A |
| 13 Jul 21 | r03 | Young BoysYoung Boys | 2 - 2 | StrasbourgStrasbourg |
| 13 Jul 21 | r03 | CovilhaCovilha | 2 - 1 | TrofenseTrofense |
| 13 Jul 21 | r03 | VV GemertVV Gemert | 2 - 2 | Helmond SportHelmond Sport |
| 13 Jul 21 | r03 | FC EindhovenFC Eindhoven | 4 - 1 | VV UNAVV UNA |
| 13 Jul 21 | r03 | St JohnstoneSt Johnstone | 1 - 1 | PrestonPreston |
| 13 Jul 21 | r03 | Leyton OrientLeyton Orient | 0 - 0 | West HamWest Ham |
| 13 Jul 21 | r03 | NorthamptonNorthampton | 1 - 2 | West HamWest Ham |
| 13 Jul 21 | r03 | DartfordDartford | - | GillinghamGillingham |
| 13 Jul 21 | r03 | StalybridgeStalybridge | 0 - 2 | OldhamOldham |
| 13 Jul 21 | r03 | Spennymoor Town FCSpennymoor To | - | DoncasterDoncaster |
| 13 Jul 21 | r03 | Stamford AFCStamford AFC | 0 - 4 | PeterboroPeterboro |
| 13 Jul 21 | r03 | LeamingtonLeamington | 3 - 1 | WalsallWalsall |
| 13 Jul 21 | r03 | Taunton TownTaunton Town | 0 - 5 | ExeterExeter |
| 13 Jul 21 | r03 | Atherton CollieriesAtherton Coll | 0 - 4 | BoltonBolton |
| 13 Jul 21 | r03 | Hungerford TownHungerford To | 3 - 2 | SwindonSwindon |
| 13 Jul 21 | r03 | Bradford Park AvenueBradford Park | 0 - 5 | BradfordBradford |
| 13 Jul 21 | r03 | Welling UnitedWelling Unite | 0 - 3 | CharltonCharlton |
| 13 Jul 21 | r03 | Brighouse TownBrighouse Tow | 0 - 1 | Harrogate Town FCHarrogate Tow |
| 13 Jul 21 | r03 | Alfreton TownAlfreton Town | 0 - 1 | Sheffield WedsSheffield Wed |
| 14 Jul 21 | r03 | GuimaraesGuimaraes | - | BoavistaBoavista |
| 14 Jul 21 | r03 | TOP OssTOP Oss | - | NEC NijmegenNEC Nijmegen |
| 14 Jul 21 | r03 | AroucaArouca | - | F.C. Paços de FerreiraF.C. Paços de |
| 14 Jul 21 | r03 | Santa ClaraSanta Clara | 3 - 0 | MoreirenseMoreirense |
| 14 Jul 21 | r03 | Gil VicenteGil Vicente | - | ChavesChaves |
| 14 Jul 21 | r03 | GentGent | - | Sporting CPSporting CP |
| 14 Jul 21 | r03 | União de LeiriaUnião de Leir | 1 - 3 | Benfica BBenfica B |
| 14 Jul 21 | r03 | Oud-Heverlee LeuvenOud-Heverlee | - | Fortuna SittardFortuna Sitta |
| 14 Jul 21 | r03 | KøgeKøge | - | Hellerup IKHellerup IK |
| 14 Jul 21 | r03 | EsbjergEsbjerg | - | Weiche Flensburg 08Weiche Flensb |
| 14 Jul 21 | r03 | LeixoesLeixoes | 2 - 1 | TorreenseTorreense |
| 14 Jul 21 | r03 | Casa PiaCasa Pia | 2 - 1 | TorreenseTorreense |
| 14 Jul 21 | r03 | Inter BratislavaInter Bratisl | 0 - 5 | GyirmótGyirmót |
| 14 Jul 21 | r03 | Mlada BoleslavMlada Bolesla | 6 - 1 | VarnsdorfVarnsdorf |
| 14 Jul 21 | r03 | Resovia RzeszówResovia Rzesz | 2 - 1 | Wisla KrakowWisla Krakow |
| 14 Jul 21 | r03 | Jagiellonia BialystokJagiellonia B | 1 - 1 | Aris LimassolAris Limassol |
| 14 Jul 21 | r03 | VizelaVizela | - | BoavistaBoavista |
| 14 Jul 21 | r03 | Korona KielceKorona Kielce | 1 - 0 | Ruch ChorzowRuch Chorzow |
| 14 Jul 21 | r03 | GenkGenk | 1 - 1 | AZ AlkmaarAZ Alkmaar |
| 14 Jul 21 | r03 | RochdaleRochdale | 1 - 2 | BarnsleyBarnsley |
| 14 Jul 21 | r03 | StuttgartStuttgart | 1 - 1 | DarmstadtDarmstadt |
| 14 Jul 21 | r03 | Cherno MoreCherno More | 1 - 0 | SozopolSozopol |
| 14 Jul 21 | r03 | BochumBochum | 6 - 0 | Bonner SCBonner SC |
| 14 Jul 21 | r03 | Almere City FCAlmere City F | 3 - 0 | MVV MaastrichtMVV Maastrich |
| 14 Jul 21 | r03 | CharleroiCharleroi | 2 - 2 | MolenbeekMolenbeek |
| 14 Jul 21 | r03 | InhuletsInhulets | 1 - 1 | Makedonija GjPMakedonija Gj |
| 14 Jul 21 | r03 | CaenCaen | 3 - 1 | OrleansOrleans |
| 14 Jul 21 | r03 | Lokomotiv SofiaLokomotiv Sof | 0 - 1 | Botev VratsaBotev Vratsa |
| 14 Jul 21 | r03 | HerthaHertha | 4 - 4 | HannoverHannover |
| 14 Jul 21 | r03 | Wuerzburger KickersWuerzburger K | 1 - 0 | SPVGG Greuther FürthSPVGG Greuthe |
| 14 Jul 21 | r03 | FC KrasnodarFC Krasnodar | 2 - 2 | Dynamo České BudějoviceDynamo České |
| 14 Jul 21 | r03 | ZeljeznicarZeljeznicar | 2 - 2 | Paksi FCPaksi FC |
| 14 Jul 21 | r03 | Khimki FKKhimki FK | 2 - 3 | PFC SochiPFC Sochi |
| 14 Jul 21 | r03 | Levski Sofia Levski Sofia | - | Septemvri SofiaSeptemvri Sof |
| 14 Jul 21 | r03 | NantesNantes | 1 - 0 | GuingampGuingamp |
| 14 Jul 21 | r03 | Stade de ReimsStade de Reim | 1 - 0 | Paris FCParis FC |
| 14 Jul 21 | r03 | Cherno MoreCherno More | 3 - 0 | DobrudzhaDobrudzha |
| 14 Jul 21 | r03 | Viktoria BerlinViktoria Berl | 2 - 5 | Union BerlinUnion Berlin |
| 14 Jul 21 | r03 | St. GilloiseSt. Gilloise | 1 - 1 | ValenciennesValenciennes |
| 14 Jul 21 | r03 | AngersAngers | - | US AvranchesUS Avranches |
| 14 Jul 21 | r03 | Clermont FootClermont Foot | 0 - 0 | GrenobleGrenoble |
| 14 Jul 21 | r03 | LeverkusenLeverkusen | - | Wehen WiesbadenWehen Wiesbad |
| 14 Jul 21 | r03 | Beerschot VABeerschot VA | 1 - 2 | FC UtrechtFC Utrecht |
| 14 Jul 21 | r03 | GKS KatowiceGKS Katowice | 2 - 1 | BełchatówBełchatów |
| 14 Jul 21 | r03 | MontpellierMontpellier | 1 - 0 | Rodez AFRodez AF |
| 14 Jul 21 | r03 | Kispest HonvedKispest Honve | 3 - 5 | PribramPribram |
| 14 Jul 21 | r03 | SD AmorebietaSD Amorebieta | 1 - 1 | BurgosBurgos |
| 14 Jul 21 | r03 | Skive IKSkive IK | 1 - 0 | HolstebroHolstebro |
| 14 Jul 21 | r03 | FC SionFC Sion | - | Dynamo KievDynamo Kiev |
| 14 Jul 21 | r03 | AjaccioAjaccio | - | GFCO AjaccioGFCO Ajaccio |
| 14 Jul 21 | r03 | KMSK DeinzeKMSK Deinze | 1 - 3 | WaregemWaregem |
| 14 Jul 21 | r03 | AlavesAlaves | 1 - 3 | SD LogroñésSD Logroñés |
| 14 Jul 21 | r03 | Atletico de San LuisAtletico de S | 1 - 0 | Correcaminos UATCorrecaminos |
| 14 Jul 21 | r03 | ThistedThisted | - | JammerbugtJammerbugt |
| 14 Jul 21 | r03 | Blauw Geel 38Blauw Geel 38 | 1 - 1 | FC Den BoschFC Den Bosch |
| 14 Jul 21 | r03 | FK Rubin KazanFK Rubin Kaza | 0 - 4 | Spartak MoscowSpartak Mosco |
| 14 Jul 21 | r03 | St Albans CitySt Albans Cit | 0 - 1 | StevenageStevenage |
| 14 Jul 21 | r03 | Bristol CityBristol City | 0 - 0 | CelticCeltic |
| 14 Jul 21 | r03 | WittonWitton | 0 - 6 | CreweCrewe |
| 14 Jul 21 | r03 | AshtonAshton | 1 - 5 | CreweCrewe |
| 14 Jul 21 | r03 | MoreliaMorelia | 3 - 0 | CS HeredianoCS Herediano |
| 15 Jul 21 | r03 | AtlasAtlas | 1 - 0 | Tampico MaderoTampico Mader |
| 15 Jul 21 | r03 | FC LvivFC Lviv | 1 - 2 | FC Kolos KovalivkaFC Kolos Kova |
| 15 Jul 21 | r03 | F.C. Paços de FerreiraF.C. Paços de | - | Santa ClaraSanta Clara |
| 15 Jul 21 | r03 | TijuanaTijuana | 0 - 0 | MazatlánMazatlán |
| 15 Jul 21 | r03 | Lask Juniors LinzLask Juniors | - | Slavia PragueSlavia Prague |
| 15 Jul 21 | r03 | MaritimoMaritimo | 4 - 0 | VarzimVarzim |
| 15 Jul 21 | r03 | Dinamo MoscowDinamo Moscow | 0 - 2 | JablonecJablonec |
| 15 Jul 21 | r03 | CovilhaCovilha | 1 - 0 | Academico ViseuAcademico Vis |
| 15 Jul 21 | r03 | SC Heracles AlmeloSC Heracles A | 2 - 1 | RödinghausenRödinghausen |
| 15 Jul 21 | r03 | Viktoria PlzenViktoria Plze | 1 - 0 | Arsenal TulaArsenal Tula |
| 15 Jul 21 | r03 | Warta PoznańWarta Poznań | 1 - 0 | Zaglebie LubinZaglebie Lubi |
| 15 Jul 21 | r03 | AEL LimassolAEL Limassol | 2 - 2 | Olympiakos NicosiaOlympiakos Ni |
| 15 Jul 21 | r03 | DAC 1904 Dunajská StredaDAC 1904 Duna | 2 - 1 | Újpest FCÚjpest FC |
| 15 Jul 21 | r03 | SlovackoSlovacko | 2 - 1 | Paksi FCPaksi FC |
| 15 Jul 21 | r03 | Apoel NicosiaApoel Nicosia | 1 - 0 | PAEEKPAEEK |
| 15 Jul 21 | r03 | Dinamo MoscowDinamo Moscow | 0 - 2 | MTK HungariaMTK Hungaria |
| 15 Jul 21 | r03 | AEK LarnacaAEK Larnaca | 1 - 0 | Doxa KatokopiasDoxa Katokopi |
| 15 Jul 21 | r03 | Kisvárda FCKisvárda FC | 3 - 2 | Maccabi Petach TikvaMaccabi Petac |
| 15 Jul 21 | r03 | Qarabag FKQarabag FK | 2 - 2 | AugsburgAugsburg |
| 15 Jul 21 | r03 | BeroeBeroe | 0 - 2 | Arda KardzhaliArda Kardzhal |
| 15 Jul 21 | r03 | StraelenStraelen | 2 - 2 | VVV-VenloVVV-Venlo |
| 15 Jul 21 | r03 | AEKAEK | 3 - 0 | Apollon LimassolApollon Limas |
| 16 Jul 21 | r03 | BenficaBenfica | - | GentGent |
| 16 Jul 21 | r03 | FreiburgFreiburg | - | VaduzVaduz |
| 16 Jul 21 | r03 | FK RostovFK Rostov | - | BurnleyBurnley |
| 16 Jul 21 | r03 | BournemouthBournemouth | 4 - 2 | LinenseLinense |
| 16 Jul 21 | r03 | Armagh CityArmagh City | 1 - 6 | ColeraineColeraine |
| 16 Jul 21 | r03 | PachucaPachuca | 1 - 3 | CD GuadalajaraCD Guadalajar |
| 16 Jul 21 | r03 | GetafeGetafe | 1 - 0 | UD IbizaUD Ibiza |
| 16 Jul 21 | r03 | NiecieczaNieciecza | 4 - 0 | Cracovia KrakowCracovia Krak |
| 16 Jul 21 | r03 | FC Lausanne-SportFC Lausanne-S | 4 - 0 | Stade Lausanne OuchyStade Lausann |
| 16 Jul 21 | r03 | Gil VicenteGil Vicente | - | FamalicaoFamalicao |
| 16 Jul 21 | r03 | AnderlechtAnderlecht | 1 - 1 | OFIOFI |
| 16 Jul 21 | r03 | KøgeKøge | 2 - 2 | FC HelsingoerFC Helsingoer |
| 16 Jul 21 | r03 | Jahn RegensburgJahn Regensbu | 1 - 0 | LiberecLiberec |
| 16 Jul 21 | r03 | Sigma OlomoucSigma Olomouc | 1 - 1 | Arka GdyniaArka Gdynia |
| 16 Jul 21 | r03 | Bohemians 1905Bohemians 190 | 5 - 0 | FK Senica FK Senica |
| 16 Jul 21 | r03 | TepliceTeplice | 1 - 2 | Dukla PrahaDukla Praha |
| 16 Jul 21 | r03 | AberdeenAberdeen | - | ReadingReading |
| 16 Jul 21 | r03 | Pafos FCPafos FC | 1 - 0 | Dynamo České BudějoviceDynamo České |
| 16 Jul 21 | r03 | Slavia PragueSlavia Prague | 1 - 1 | Piast GliwicePiast Gliwice |
| 16 Jul 21 | r03 | Dynamo České BudějoviceDynamo České | 0 - 1 | Pafos FCPafos FC |
| 16 Jul 21 | r03 | AugsburgAugsburg | - | IngolstadtIngolstadt |
| 16 Jul 21 | r03 | Triglav KranjTriglav Kranj | 1 - 1 | MTK HungariaMTK Hungaria |
| 16 Jul 21 | r03 | FK RostovFK Rostov | 1 - 0 | Beitar JerusalemBeitar Jerusa |
| 16 Jul 21 | r03 | Cherno MoreCherno More | 3 - 0 | Neftochimic BurgasNeftochimic B |
| 16 Jul 21 | r03 | Lokomotiv Plovdiv Lokomotiv Plo | 1 - 0 | Hebar PazardzhikHebar Pazardz |
| 16 Jul 21 | r03 | Yverdon SportYverdon Sport | 1 - 3 | SochauxSochaux |
| 16 Jul 21 | r03 | SC VerlSC Verl | 3 - 2 | FC GroningenFC Groningen |
| 16 Jul 21 | r03 | Germania HalberstadtGermania Halb | 3 - 1 | Rot-Weiß ErfurtRot-Weiß Erfu |
| 16 Jul 21 | r03 | St EtienneSt Etienne | 1 - 1 | Bourg-PeronnasBourg-Peronna |
| 16 Jul 21 | r03 | BeroeBeroe | 6 - 0 | SozopolSozopol |
| 16 Jul 21 | r03 | BastiaBastia | 1 - 0 | NiceNice |
| 16 Jul 21 | r03 | MVV MaastrichtMVV Maastrich | - | Helmond SportHelmond Sport |
| 16 Jul 21 | r03 | Helmond SportHelmond Sport | - | FC DordrechtFC Dordrecht |
| 16 Jul 21 | r03 | BordeauxBordeaux | 1 - 1 | NiortNiort |
| 16 Jul 21 | r03 | Lokomotive LeipzigLokomotive Le | 2 - 0 | VfV HildesheimVfV Hildeshei |
| 16 Jul 21 | r03 | AberdeenAberdeen | 0 - 0 | St JohnstoneSt Johnstone |
| 16 Jul 21 | r03 | Drochtersen-AsselDrochtersen-A | 0 - 1 | OberneulandOberneuland |
| 16 Jul 21 | r03 | SV TECSV TEC | 3 - 0 | Jong UtrechtJong Utrecht |
| 16 Jul 21 | r03 | GillinghamGillingham | - | QPRQPR |
| 16 Jul 21 | r03 | Kings Lynn TownKings Lynn To | 1 - 3 | NorwichNorwich |
| 16 Jul 21 | r03 | Oxford CityOxford City | 2 - 3 | Oxford UtdOxford Utd |
| 16 Jul 21 | r03 | Raith RvsRaith Rvs | 1 - 3 | HibernianHibernian |
| 16 Jul 21 | r03 | SC FarenseSC Farense | 0 - 0 | BragaBraga |
| 16 Jul 21 | r03 | MatlockMatlock | 1 - 0 | MansfieldMansfield |
| 16 Jul 21 | r03 | WokingWoking | 0 - 1 | West BromWest Brom |
| 17 Jul 21 | r03 | Wisla PlockWisla Plock | - | Lechia GdańskLechia Gdańsk |
| 17 Jul 21 | r03 | Amsterdamsche FCAmsterdamsche | - | SC TelstarSC Telstar |
| 17 Jul 21 | r03 | Apollon LimassolApollon Limas | - | Doxa KatokopiasDoxa Katokopi |
| 17 Jul 21 | r03 | VolynVolyn | - | FC LvivFC Lviv |
| 17 Jul 21 | r03 | CD TeruelCD Teruel | - | ZaragozaZaragoza |
| 17 Jul 21 | r03 | GuimaraesGuimaraes | - | Gil VicenteGil Vicente |
| 17 Jul 21 | r03 | AroucaArouca | - | ChavesChaves |
| 17 Jul 21 | r03 | Casa PiaCasa Pia | - | Benfica BBenfica B |
| 17 Jul 21 | r03 | TolucaToluca | - | AtlanteAtlante |
| 17 Jul 21 | r03 | NurnbergNurnberg | - | Beerschot VABeerschot VA |
| 17 Jul 21 | r03 | FC PortoFC Porto | 3 - 2 | Academico ViseuAcademico Vis |
| 17 Jul 21 | r03 | Slaven Belupo KoprivnicaSlaven Belupo | 2 - 2 | SesveteSesvete |
| 17 Jul 21 | r03 | TepliceTeplice | - | Dukla PrahaDukla Praha |
| 17 Jul 21 | r03 | FremFrem | - | AB GladsaxeAB Gladsaxe |
| 17 Jul 21 | r03 | De GraafschapDe Graafschap | 4 - 0 | FC DordrechtFC Dordrecht |
| 17 Jul 21 | r03 | LinfieldLinfield | 0 - 6 | StokeStoke |
| 17 Jul 21 | r03 | BlackpoolBlackpool | 1 - 3 | AccringtonAccrington |
| 17 Jul 21 | r03 | HeartsHearts | 0 - 2 | SunderlandSunderland |
| 17 Jul 21 | r03 | FC LvivFC Lviv | 1 - 0 | Nyva TernopilNyva Ternopil |
| 17 Jul 21 | r03 | Lokomotiv SofiaLokomotiv Sof | 3 - 1 | Levski LomLevski Lom |
| 17 Jul 21 | r03 | SSV UlmSSV Ulm | 2 - 1 | Stuttgarter KickersStuttgarter K |
| 17 Jul 21 | r03 | StrasbourgStrasbourg | 0 - 1 | FC SionFC Sion |
| 17 Jul 21 | r03 | Excelsior MaassluisExcelsior Maa | 2 - 1 | SC TelstarSC Telstar |
| 17 Jul 21 | r03 | Tsarsko SeloTsarsko Selo | 0 - 0 | Pirin BlagoevgradPirin Blagoev |
| 17 Jul 21 | r03 | ViOn Zlaté MoravceViOn Zlaté Mo | 2 - 1 | ŠKF SereďŠKF Sereď |
| 17 Jul 21 | r03 | Zaglebie SosnowiecZaglebie Sosn | 2 - 2 | GKS KatowiceGKS Katowice |
| 17 Jul 21 | r03 | FuenlabradaFuenlabrada | 2 - 1 | AlcorconAlcorcon |
| 17 Jul 21 | r03 | Sepsi OSK Sfântu GheorgheSepsi OSK Sfâ | 2 - 0 | Politehnica IașiPolitehnica I |
| 17 Jul 21 | r03 | PortimonensePortimonense | 1 - 1 | BragaBraga |
| 17 Jul 21 | r03 | JastrzębieJastrzębie | 2 - 0 | Odra OpoleOdra Opole |
| 17 Jul 21 | r03 | TáborskoTáborsko | - | Viktoria PlzenViktoria Plze |
| 17 Jul 21 | r03 | LíšeňLíšeň | - | Banik OstravaBanik Ostrava |
| 17 Jul 21 | r03 | Tychy 71Tychy 71 | 1 - 1 | SFC OpavaSFC Opava |
| 17 Jul 21 | r03 | Puszcza NiepołomicePuszcza Niepo | 2 - 4 | Sandecja Nowy SaczSandecja Nowy |
| 17 Jul 21 | r03 | GyirmótGyirmót | 2 - 1 | AjkaAjka |
| 17 Jul 21 | r03 | FK RostovFK Rostov | 0 - 1 | Kispest HonvedKispest Honve |
| 17 Jul 21 | r03 | Kolding IFKolding IF | 4 - 1 | VSK ÅrhusVSK Århus |
| 17 Jul 21 | r03 | LeixoesLeixoes | 4 - 1 | CaldasCaldas |
| 17 Jul 21 | r03 | VizelaVizela | 0 - 0 | Estoril-PraiaEstoril-Praia |
| 17 Jul 21 | r03 | FredericiaFredericia | 0 - 2 | AC HorsensAC Horsens |
| 17 Jul 21 | r03 | Chojniczanka ChojniceChojniczanka | 3 - 1 | Chrobry GłogówChrobry Głogó |
| 17 Jul 21 | r03 | EsbjergEsbjerg | 1 - 2 | Aarhus FremadAarhus Fremad |
| 17 Jul 21 | r03 | Jagiellonia BialystokJagiellonia B | 4 - 0 | Gornik LecznaGornik Leczna |
| 17 Jul 21 | r03 | WatfordWatford | 2 - 1 | ColchesterColchester |
| 17 Jul 21 | r03 | NurnbergNurnberg | 3 - 2 | Munich 1860Munich 1860 |
| 17 Jul 21 | r03 | HOBROHOBRO | 3 - 0 | JammerbugtJammerbugt |
| 17 Jul 21 | r03 | LyngbyLyngby | 2 - 0 | Fremad AmagerFremad Amager |
| 17 Jul 21 | r03 | Stamford AFCStamford AFC | 2 - 1 | NorthamptonNorthampton |
| 17 Jul 21 | r03 | BarnsleyBarnsley | 2 - 0 | Sheffield WedsSheffield Wed |
| 17 Jul 21 | r03 | MolenbeekMolenbeek | 0 - 1 | SC CambuurSC Cambuur |
| 17 Jul 21 | r03 | WycombeWycombe | 1 - 0 | StevenageStevenage |
| 17 Jul 21 | r03 | BlackpoolBlackpool | 1 - 3 | NewportNewport |
| 17 Jul 21 | r03 | FC HeidenheimFC Heidenheim | 1 - 0 | HoffenheimHoffenheim |
| 17 Jul 21 | r03 | VSG AltglienickeVSG Altglieni | 3 - 3 | Hertha IIHertha II |
| 17 Jul 21 | r03 | SC HeerenveenSC Heerenveen | 3 - 2 | TOP OssTOP Oss |
| 17 Jul 21 | r03 | TSV HavelseTSV Havelse | 1 - 1 | CottbusCottbus |
| 17 Jul 21 | r03 | WaregemWaregem | 0 - 0 | FC UtrechtFC Utrecht |
| 17 Jul 21 | r03 | Lech PoznanLech Poznan | - | Miedz LegnicaMiedz Legnica |
| 17 Jul 21 | r03 | Lucerne Lucerne | 2 - 0 | FC WilFC Wil |
| 17 Jul 21 | r03 | CardiffCardiff | - | Cambridge UnitedCambridge Uni |
| 17 Jul 21 | r03 | Optik RathenowOptik Ratheno | 2 - 2 | Greifswalder FCGreifswalder |
| 17 Jul 21 | r03 | Chemnitzer FCChemnitzer FC | 1 - 1 | Viktoria BerlinViktoria Berl |
| 17 Jul 21 | r03 | FC EmmenFC Emmen | - | Jong UtrechtJong Utrecht |
| 17 Jul 21 | r03 | Yate TownYate Town | 0 - 2 | Forest Green RoversForest Green |
| 17 Jul 21 | r03 | KarlsruheKarlsruhe | 1 - 0 | FC SaarbrückenFC Saarbrücke |
| 17 Jul 21 | r03 | Wehen WiesbadenWehen Wiesbad | 1 - 2 | ElversbergElversberg |
| 17 Jul 21 | r03 | Hallescher FCHallescher FC | 2 - 2 | Holstein KielHolstein Kiel |
| 17 Jul 21 | r03 | De GraafschapDe Graafschap | - | FC EindhovenFC Eindhoven |
| 17 Jul 21 | r03 | WalsallWalsall | 0 - 1 | Crystal PalaceCrystal Palac |
| 17 Jul 21 | r03 | Hannover IIHannover II | 0 - 3 | Fortuna Düsseldorf IIFortuna Düsse |
| 17 Jul 21 | r03 | Spennymoor Town FCSpennymoor To | - | BarrowBarrow |
| 17 Jul 21 | r03 | FC EilenburgFC Eilenburg | 3 - 0 | Bischofswerdaer FVBischofswerda |
| 17 Jul 21 | r03 | Wuerzburger KickersWuerzburger K | 1 - 2 | Carl Zeiss JenaCarl Zeiss Je |
| 17 Jul 21 | r03 | ZwickauZwickau | 1 - 1 | Ústí nad LabemÚstí nad Labe |
| 17 Jul 21 | r03 | FC DordrechtFC Dordrecht | - | ExcelsiorExcelsior |
| 17 Jul 21 | r03 | Quick BoysQuick Boys | 2 - 0 | Jong PSVJong PSV |
| 17 Jul 21 | r03 | Bristol RoversBristol Rover | 1 - 1 | PlymouthPlymouth |
| 17 Jul 21 | r03 | Jong AjaxJong Ajax | 1 - 4 | FC EmmenFC Emmen |
| 17 Jul 21 | r03 | KaiserslauternKaiserslauter | 2 - 0 | Stuttgart IIStuttgart II |
| 17 Jul 21 | r03 | Waldhof MannheimWaldhof Mannh | 5 - 3 | FC GießenFC Gießen |
| 17 Jul 21 | r03 | Hansa RostockHansa Rostock | 1 - 2 | BraunschweigBraunschweig |
| 17 Jul 21 | r03 | Skive IKSkive IK | 2 - 0 | MiddelfartMiddelfart |
| 17 Jul 21 | r03 | Willem IIWillem II | 2 - 0 | ExcelsiorExcelsior |
| 17 Jul 21 | r03 | NAC BredaNAC Breda | 2 - 1 | FC Den BoschFC Den Bosch |
| 17 Jul 21 | r03 | MechelenMechelen | 2 - 1 | NFC VolosNFC Volos |
| 17 Jul 21 | r03 | HannoverHannover | 2 - 4 | MagdeburgMagdeburg |
| 17 Jul 21 | r03 | GrasshoppersGrasshoppers | 2 - 3 | ThunThun |
| 17 Jul 21 | r03 | OsnabrueckOsnabrueck | 0 - 1 | FC GroningenFC Groningen |
| 17 Jul 21 | r03 | PaderbornPaderborn | 3 - 1 | MönchengladbachMönchengladba |
| 17 Jul 21 | r03 | FC OlexandriaFC Olexandria | 2 - 2 | Kryvbas Kryvyi RihKryvbas Kryvy |
| 17 Jul 21 | r03 | FK Rubin KazanFK Rubin Kaza | 1 - 3 | PFC SochiPFC Sochi |
| 17 Jul 21 | r03 | ZurichZurich | 6 - 1 | SC KriensSC Kriens |
| 17 Jul 21 | r03 | St.TruidenSt.Truiden | 1 - 1 | EupenEupen |
| 17 Jul 21 | r03 | CaenCaen | 1 - 0 | NantesNantes |
| 17 Jul 21 | r03 | Ein FrankfurtEin Frankfurt | 1 - 0 | SandhausenSandhausen |
| 17 Jul 21 | r03 | Jahn RegensburgJahn Regensbu | 1 - 0 | Türkgücü MünchenTürkgücü Münc |
| 17 Jul 21 | r03 | Fortuna DüsseldorfFortuna Düsse | 3 - 0 | Oud-Heverlee LeuvenOud-Heverlee |
| 17 Jul 21 | r03 | LensLens | 2 - 2 | Le HavreLe Havre |
| 17 Jul 21 | r03 | TijuanaTijuana | 3 - 0 | CS HeredianoCS Herediano |
| 17 Jul 21 | r03 | SouthportSouthport | 0 - 2 | Huddersfield TownHuddersfield |
| 17 Jul 21 | r03 | CheltenhamCheltenham | 0 - 3 | BirminghamBirmingham |
| 17 Jul 21 | r03 | RasenBallsport LeipzigRasenBallspor | 1 - 0 | AZ AlkmaarAZ Alkmaar |
| 17 Jul 21 | r03 | DartfordDartford | 1 - 2 | CharltonCharlton |
| 17 Jul 21 | r03 | FC United of ManchesterFC United of | 1 - 1 | BoltonBolton |
| 17 Jul 21 | r03 | MaidstoneMaidstone | - | Sutton UnitedSutton United |
| 17 Jul 21 | r03 | Boreham WoodBoreham Wood | 1 - 3 | LutonLuton |
| 17 Jul 21 | r03 | Alfreton TownAlfreton Town | 3 - 2 | ChesterfieldChesterfield |
| 17 Jul 21 | r03 | SwindonSwindon | - | SwanseaSwansea |
| 17 Jul 21 | r03 | OldhamOldham | 1 - 2 | WiganWigan |
| 17 Jul 21 | r03 | Farsley CelticFarsley Celti | - | ScunthorpeScunthorpe |
| 17 Jul 21 | r03 | RochdaleRochdale | 3 - 3 | Fleetwood TownFleetwood Tow |
| 17 Jul 21 | r03 | Mlada BoleslavMlada Bolesla | 4 - 1 | Viktoria ŽižkovViktoria Žižk |
| 17 Jul 21 | r03 | Lommel SKLommel SK | 1 - 1 | Roda JCRoda JC |
| 17 Jul 21 | r03 | BradfordBradford | 2 - 0 | DoncasterDoncaster |
| 17 Jul 21 | r03 | ChorleyChorley | 1 - 0 | MorecambeMorecambe |
| 17 Jul 21 | r03 | Elgin CityElgin City | 3 - 0 | Nairn CountyNairn County |
| 17 Jul 21 | r03 | Boston United FCBoston United | 5 - 0 | LincolnLincoln |
| 17 Jul 21 | r03 | HorshamHorsham | 0 - 5 | CrawleyCrawley |
| 17 Jul 21 | r03 | TamworthTamworth | - | ShrewsburyShrewsbury |
| 17 Jul 21 | r03 | St. GallenSt. Gallen | 2 - 1 | Ath BilbaoAth Bilbao |
| 17 Jul 21 | r03 | FarnboroughFarnborough | 5 - 7 | AldershotAldershot |
| 17 Jul 21 | r03 | SC Dnipro-1SC Dnipro-1 | 2 - 0 | Alians Lypova DolynaAlians Lypova |
| 17 Jul 21 | r03 | Fortuna SittardFortuna Sitta | 1 - 1 | Beerschot VABeerschot VA |
| 17 Jul 21 | r03 | Port ValePort Vale | 0 - 2 | Nottingham F.Nottingham F. |
| 17 Jul 21 | r03 | AFC WimbledonAFC Wimbledon | 0 - 1 | BrentfordBrentford |
| 17 Jul 21 | r03 | Almere City FCAlmere City F | 3 - 3 | SV MeppenSV Meppen |
| 17 Jul 21 | r03 | Braintree TownBraintree Tow | 3 - 4 | Dagenham & Red.Dagenham & Re |
| 17 Jul 21 | r03 | AmiensAmiens | 3 - 4 | St. GilloiseSt. Gilloise |
| 17 Jul 21 | r03 | AtlasAtlas | 1 - 1 | Atletico de San LuisAtletico de S |
| 17 Jul 21 | r03 | Casa PiaCasa Pia | 1 - 0 | MafraMafra |
| 17 Jul 21 | r03 | CreweCrewe | 1 - 0 | WolvesWolves |
| 17 Jul 21 | r03 | Gornik ZabrzeGornik Zabrze | 1 - 3 | Banik OstravaBanik Ostrava |
| 17 Jul 21 | r03 | MFK RužomberokMFK Ružombero | 2 - 1 | KarvinaKarvina |
| 17 Jul 21 | r03 | ZlínZlín | 1 - 1 | Zbrojovka BrnoZbrojovka Brn |
| 17 Jul 21 | r03 | PardubicePardubice | 2 - 0 | VlašimVlašim |
| 17 Jul 21 | r03 | Hradec KrálovéHradec Králov | 2 - 0 | ChrudimChrudim |
| 17 Jul 21 | r03 | NEC NijmegenNEC Nijmegen | 3 - 0 | RKC WaalwijkRKC Waalwijk |
| 17 Jul 21 | r03 | DijonDijon | 1 - 2 | TroyesTroyes |
| 17 Jul 21 | r03 | ZurichZurich | 1 - 4 | Neuchâtel XamaxNeuchâtel Xam |
| 17 Jul 21 | r03 | Botev VratsaBotev Vratsa | 1 - 1 | Apollon SmirnisApollon Smirn |
| 17 Jul 21 | r03 | Aris LimassolAris Limassol | 0 - 1 | Wisla PlockWisla Plock |
| 17 Jul 21 | r03 | MetzMetz | 1 - 1 | RFC SeraingRFC Seraing |
| 17 Jul 21 | r03 | LorientLorient | 3 - 2 | BrestBrest |
| 17 Jul 21 | r03 | StandardStandard | 3 - 3 | RennesRennes |
| 17 Jul 21 | r03 | KortrijkKortrijk | 1 - 1 | LilleLille |
| 17 Jul 21 | r03 | AntwerpAntwerp | 0 - 0 | MonacoMonaco |
| 17 Jul 21 | r03 | Dinamo MoscowDinamo Moscow | 3 - 0 | Budafoki MTEBudafoki MTE |
| 17 Jul 21 | r03 | AuxerreAuxerre | 1 - 3 | OrleansOrleans |
| 17 Jul 21 | r03 | ChateaurouxChateauroux | 0 - 3 | AngersAngers |
| 17 Jul 21 | r03 | NimesNimes | 1 - 0 | AjaccioAjaccio |
| 17 Jul 21 | r03 | LKS LodzLKS Lodz | - | Korona KielceKorona Kielce |
| 17 Jul 21 | r03 | Levski Sofia Levski Sofia | 2 - 0 | Etar Veliko TarnovoEtar Veliko T |
| 17 Jul 21 | r03 | ToulouseToulouse | 2 - 0 | Rodez AFRodez AF |
| 17 Jul 21 | r03 | ValenciennesValenciennes | 0 - 1 | Stade de ReimsStade de Reim |
| 17 Jul 21 | r03 | Clermont FootClermont Foot | 3 - 2 | MontpellierMontpellier |
| 17 Jul 21 | r03 | AlavesAlaves | 5 - 2 | SD AmorebietaSD Amorebieta |
| 17 Jul 21 | r03 | StrasbourgStrasbourg | - | Cercle BruggeCercle Brugge |
| 17 Jul 21 | r03 | Kispest HonvedKispest Honve | - | Al-EttifaqAl-Ettifaq |
| 17 Jul 21 | r03 | Slavia SofiaSlavia Sofia | 4 - 0 | MontanaMontana |
| 17 Jul 21 | r03 | St EtienneSt Etienne | 2 - 1 | GrenobleGrenoble |
| 17 Jul 21 | r03 | LyonLyon | 2 - 0 | FC VillefrancheFC Villefranc |
| 17 Jul 21 | r03 | Ethnikos AchnaEthnikos Achn | 0 - 2 | Anorthosis FamagustaAnorthosis Fa |
| 17 Jul 21 | r03 | Wisla KrakowWisla Krakow | 1 - 1 | Podbeskidzie Bielsko-BialPodbeskidzie |
| 17 Jul 21 | r03 | NiceNice | 2 - 1 | Dynamo KievDynamo Kiev |
| 17 Jul 21 | r03 | Cristo AtléticoCristo Atléti | - | ValladolidValladolid |
| 17 Jul 21 | r03 | Atlético SanluqueñoAtlético Sanl | 1 - 0 | CadizCadiz |
| 17 Jul 21 | r03 | NecaxaNecaxa | 2 - 0 | Queretaro FCQueretaro FC |
| 18 Jul 21 | r03 | BenficaBenfica | - | BoavistaBoavista |
| 18 Jul 21 | r03 | SantosSantos | - | Tepatitlán FCTepatitlán FC |
| 18 Jul 21 | r03 | MoreirenseMoreirense | - | Academico ViseuAcademico Vis |
| 18 Jul 21 | r03 | LeverkusenLeverkusen | - | Dinamo MoscowDinamo Moscow |
| 18 Jul 21 | r03 | NantesNantes | 0 - 1 | NiortNiort |
| 18 Jul 21 | r03 | Dortmund IIDortmund II | 1 - 2 | Preußen MünsterPreußen Münst |
| 18 Jul 21 | r03 | ChievoChievo | 1 - 1 | Virtus VeronaVirtus Verona |
| 18 Jul 21 | r03 | SalernitanaSalernitana | 6 - 0 | A.S.D. Città di Foligno 1A.S.D. Città |
| 18 Jul 21 | r03 | ElcheElche | 6 - 1 | AtromitosAtromitos |
| 18 Jul 21 | r03 | WesterloWesterlo | 1 - 3 | MechelenMechelen |
| 18 Jul 21 | r03 | CovilhaCovilha | 1 - 1 | PortimonensePortimonense |
| 18 Jul 21 | r03 | YorkYork | 1 - 0 | NewcastleNewcastle |
| 18 Jul 21 | r03 | Krylya Sovetov SamaraKrylya Soveto | 0 - 1 | Ural S.RUral S.R |
| 18 Jul 21 | r03 | Harrogate Town FCHarrogate Tow | - | NewcastleNewcastle |
| 18 Jul 21 | r03 | Club BruggeClub Brugge | 3 - 0 | Lierse KempenzonenLierse Kempen |
| 18 Jul 21 | r03 | FC KrasnodarFC Krasnodar | - | BielefeldBielefeld |
| 18 Jul 21 | r03 | Freiburg IIFreiburg II | 1 - 0 | MulhouseMulhouse |
| 18 Jul 21 | r03 | FC KolnFC Koln | 2 - 0 | SchaffhausenSchaffhausen |
| 18 Jul 21 | r03 | Lüneburger SK HansaLüneburger SK | 0 - 2 | LübeckLübeck |
| 18 Jul 21 | r03 | SC Dnipro-1SC Dnipro-1 | 0 - 1 | ZoryaZorya |
| 18 Jul 21 | r03 | VizelaVizela | 0 - 1 | MaritimoMaritimo |
| 18 Jul 21 | r03 | Khimki FKKhimki FK | 1 - 5 | Spartak MoscowSpartak Mosco |
| 18 Jul 21 | r03 | Spartak MoscowSpartak Mosco | 5 - 1 | Khimki FKKhimki FK |
| 19 Jul 21 | r03 | GranadaGranada | 2 - 1 | BournemouthBournemouth |
| 19 Jul 21 | r03 | GenkGenk | 5 - 2 | MVV MaastrichtMVV Maastrich |
| 19 Jul 21 | r03 | Bishops StortfordBishops Stort | - | Kings Lynn TownKings Lynn To |
| 20 Jul 21 | r03 | GillinghamGillingham | - | PeterboroPeterboro |
| 20 Jul 21 | r03 | Apoel NicosiaApoel Nicosia | 0 - 0 | Apollon SmirnisApollon Smirn |
| 20 Jul 21 | r03 | TOP OssTOP Oss | 2 - 2 | SV OSS 20SV OSS 20 |
| 20 Jul 21 | r03 | Benfica BBenfica B | 3 - 2 | MafraMafra |
| 20 Jul 21 | r03 | BurnleyBurnley | 2 - 1 | MorecambeMorecambe |
| 20 Jul 21 | r03 | BurnleyBurnley | 4 - 0 | Salford CitySalford City |
| 20 Jul 21 | r03 | Newry City AFCNewry City AF | 1 - 0 | Warrenpoint TownWarrenpoint T |
| 20 Jul 21 | r03 | FC PortoFC Porto | - | AnadiaAnadia |
| 20 Jul 21 | r03 | MaritimoMaritimo | 1 - 2 | F.C. Paços de FerreiraF.C. Paços de |
| 20 Jul 21 | r03 | VV NoordwijkVV Noordwijk | - | Jong PSVJong PSV |
| 20 Jul 21 | r03 | StevenageStevenage | - | IpswichIpswich |
| 20 Jul 21 | r03 | BirminghamBirmingham | 1 - 1 | BarrowBarrow |
| 20 Jul 21 | r03 | PEC ZwollePEC Zwolle | 3 - 0 | Helmond SportHelmond Sport |
| 20 Jul 21 | r03 | Bristol CityBristol City | 3 - 3 | PortsmouthPortsmouth |
| 20 Jul 21 | r03 | Ath BilbaoAth Bilbao | 1 - 0 | Dynamo KievDynamo Kiev |
| 20 Jul 21 | r03 | Sheffield WedsSheffield Wed | 0 - 2 | West BromWest Brom |
| 20 Jul 21 | r03 | SC TelstarSC Telstar | - | SC Heracles AlmeloSC Heracles A |
| 20 Jul 21 | r03 | NFC VolosNFC Volos | 0 - 1 | KMSK DeinzeKMSK Deinze |
| 20 Jul 21 | r03 | NorwichNorwich | 1 - 0 | LincolnLincoln |
| 20 Jul 21 | r03 | MansfieldMansfield | 0 - 1 | GrimsbyGrimsby |
| 20 Jul 21 | r03 | Rot-Weiss EssenRot-Weiss Ess | 0 - 3 | FC EmmenFC Emmen |
| 20 Jul 21 | r03 | LazioLazio | - | A.C. Belluno 1905A.C. Belluno |
| 20 Jul 21 | r03 | Real Sociedad BReal Sociedad | 3 - 1 | Osasuna BOsasuna B |
| 20 Jul 21 | r03 | VV ASWHVV ASWH | 0 - 1 | FC DordrechtFC Dordrecht |
| 20 Jul 21 | r03 | Forest Green RoversForest Green | 1 - 2 | CardiffCardiff |
| 20 Jul 21 | r03 | BoltonBolton | 1 - 0 | PrestonPreston |
| 20 Jul 21 | r03 | CreweCrewe | 2 - 3 | StokeStoke |
| 20 Jul 21 | r03 | PlymouthPlymouth | 1 - 2 | SwanseaSwansea |
| 20 Jul 21 | r03 | RochdaleRochdale | 2 - 2 | RotherhamRotherham |
| 20 Jul 21 | r03 | Kidderminster HarriersKidderminster | 1 - 2 | CheltenhamCheltenham |
| 20 Jul 21 | r03 | Sporting CPSporting CP | 2 - 0 | AngersAngers |
| 20 Jul 21 | r03 | StalybridgeStalybridge | 1 - 3 | TranmereTranmere |
| 20 Jul 21 | r03 | WeymouthWeymouth | 2 - 3 | ExeterExeter |
| 20 Jul 21 | r03 | Boreham WoodBoreham Wood | 0 - 2 | BrentfordBrentford |
| 20 Jul 21 | r03 | ScunthorpeScunthorpe | 2 - 1 | BurtonBurton |
| 20 Jul 21 | r03 | ChorleyChorley | 0 - 2 | CarlisleCarlisle |
| 20 Jul 21 | r03 | Swindon SupermarineSwindon Super | 2 - 3 | SwindonSwindon |
| 20 Jul 21 | r03 | GuiseleyGuiseley | 1 - 2 | BradfordBradford |
| 20 Jul 21 | r03 | AFC FyldeAFC Fylde | 0 - 1 | WiganWigan |
| 20 Jul 21 | r03 | KingstonianKingstonian | 2 - 0 | AFC WimbledonAFC Wimbledon |
| 20 Jul 21 | r03 | Metropolitan Police FCMetropolitan | 0 - 1 | AFC WimbledonAFC Wimbledon |
| 20 Jul 21 | r03 | St Albans CitySt Albans Cit | 1 - 1 | WealdstoneWealdstone |
| 20 Jul 21 | r03 | HerefordHereford | 1 - 2 | ShrewsburyShrewsbury |
| 20 Jul 21 | r03 | NorthamptonNorthampton | 0 - 2 | Nottingham F.Nottingham F. |
| 21 Jul 21 | r03 | Hartford AthleticHartford Athl | - | Western Mass PioneersWestern Mass |
| 21 Jul 21 | r03 | Wacker InnsbruckWacker Innsbr | - | GenoaGenoa |
| 21 Jul 21 | r03 | Anorthosis FamagustaAnorthosis Fa | - | Hapoel HaifaHapoel Haifa |
| 21 Jul 21 | r03 | Real OviedoReal Oviedo | 2 - 0 | Rayo MajadahondaRayo Majadaho |
| 21 Jul 21 | r03 | EspanolEspanol | 0 - 1 | Las PalmasLas Palmas |
| 21 Jul 21 | r03 | SC Heracles AlmeloSC Heracles A | 1 - 2 | PAOKPAOK |
| 21 Jul 21 | r03 | Podbeskidzie Bielsko-BialPodbeskidzie | 0 - 2 | Chrobry GłogówChrobry Głogó |
| 21 Jul 21 | r03 | Stade de ReimsStade de Reim | 0 - 2 | FC ChamblyFC Chambly |
| 21 Jul 21 | r03 | Parma Calcio 1913Parma Calcio | 0 - 1 | BochumBochum |
| 21 Jul 21 | r03 | Fortuna SittardFortuna Sitta | 1 - 1 | OFIOFI |
| 21 Jul 21 | r03 | St EtienneSt Etienne | - | NiceNice |
| 21 Jul 21 | r03 | Preußen MünsterPreußen Münst | 1 - 0 | Werder Bremen IIWerder Bremen |
| 21 Jul 21 | r03  | ValenciaValencia | 3 - 0 | AtromitosAtromitos |
| 21 Jul 21 | r03 | GetafeGetafe | 2 - 1 | RennesRennes |
| 21 Jul 21 | r03 | LinenseLinense | 0 - 2 | CadizCadiz |
| 21 Jul 21 | r03 | BrestBrest | 1 - 2 | Stade BriochinStade Briochi |
| 21 Jul 21 | r03 | YorkYork | 1 - 1 | SunderlandSunderland |
| 21 Jul 21 | r03 | VV UNAVV UNA | 2 - 0 | FC Den BoschFC Den Bosch |
| 21 Jul 21 | r03 | ReadingReading | 0 - 3 | West HamWest Ham |
| 21 Jul 21 | r03 | AshtonAshton | 0 - 2 | StockportStockport |
| 21 Jul 21 | r03 | BlackpoolBlackpool | - | RangersRangers |
| 21 Jul 21 | r03 | VélezVélez | 0 - 2 | MalagaMalaga |
| 21 Jul 21 | r03 | MatlockMatlock | 1 - 3 | ChesterfieldChesterfield |
| 21 Jul 21 | r03 | Harrogate Town FCHarrogate Tow | 1 - 3 | RotherhamRotherham |
| 21 Jul 21 | r03 | Brighouse TownBrighouse Tow | 1 - 3 | BradfordBradford |
| 21 Jul 21 | r03 | WalsallWalsall | 0 - 4 | Aston VillaAston Villa |
| 21 Jul 21 | r03 | ArbroathArbroath | 1 - 4 | St JohnstoneSt Johnstone |
| 21 Jul 21 | r03 | BragaBraga | 1 - 1 | MarseilleMarseille |
| 22 Jul 21 | r03 | KolubaraKolubara | 1 - 1 | Hapoel Hadera EranHapoel Hadera |
| 22 Jul 21 | r03 | Hapoel Kiryat ShmonaHapoel Kiryat | - | Al SharjahAl Sharjah |
| 22 Jul 21 | r03 | LyonLyon | 2 - 2 | VillarrealVillarreal |
| 22 Jul 21 | r03 | Olympiakos NicosiaOlympiakos Ni | 2 - 1 | Doxa KatokopiasDoxa Katokopi |
| 22 Jul 21 | r03 | BenficaBenfica | 1 - 0 | LilleLille |
| 23 Jul 21 | r03 | MorecambeMorecambe | 0 - 0 | BarnsleyBarnsley |
| 23 Jul 21 | r03 | Hapoel Tel-AvivHapoel Tel-Av | 1 - 3 | Arka GdyniaArka Gdynia |
| 23 Jul 21 | r03 | Górnik PolkowiceGórnik Polkow | 1 - 1 | Odra OpoleOdra Opole |
| 23 Jul 21 | r03 | Korona KielceKorona Kielce | 2 - 1 | Sandecja Nowy SaczSandecja Nowy |
| 23 Jul 21 | r03 | FC GroningenFC Groningen | - | FC VolendamFC Volendam |
| 23 Jul 21 | r03 | NorwichNorwich | 2 - 0 | Huddersfield TownHuddersfield |
| 23 Jul 21 | r03 | FC GroningenFC Groningen | - | SC HeerenveenSC Heerenveen |
| 23 Jul 21 | r03 | Roda JCRoda JC | 2 - 4 | RKC WaalwijkRKC Waalwijk |
| 23 Jul 21 | r03 | Apoel NicosiaApoel Nicosia | 0 - 1 | Bnei SakhninBnei Sakhnin |
| 23 Jul 21 | r03 | Zaglebie SosnowiecZaglebie Sosn | 4 - 0 | Puszcza NiepołomicePuszcza Niepo |
| 23 Jul 21 | r03 | LKS LodzLKS Lodz | 3 - 0 | Znicz PruszkówZnicz Pruszkó |
| 23 Jul 21 | r03 | RasenBallsport LeipzigRasenBallspor | 1 - 2 | MontpellierMontpellier |
| 23 Jul 21 | r03 | SpartaSparta | 1 - 2 | NAC BredaNAC Breda |
| 23 Jul 21 | r03 | FC DordrechtFC Dordrecht | 2 - 3 | Almere City FCAlmere City F |
| 23 Jul 21 | r03 | BresciaBrescia | - | Real CalepinaReal Calepina |
| 23 Jul 21 | r03 | SSV JeddelohSSV Jeddeloh | 0 - 1 | RödinghausenRödinghausen |
| 23 Jul 21 | r03  | LazioLazio | 5 - 2 | TriestinaTriestina |
| 23 Jul 21 | r03 | Atlas DelmenhorstAtlas Delmenh | 2 - 2 | VfL OldenburgVfL Oldenburg |
| 23 Jul 21 | r03 | FC EindhovenFC Eindhoven | - | Lommel SKLommel SK |
| 23 Jul 21 | r03 | Go Ahead EaglesGo Ahead Eagl | 1 - 1 | VitesseVitesse |
| 23 Jul 21 | r03 | VVV-VenloVVV-Venlo | 1 - 4 | Helmond SportHelmond Sport |
| 23 Jul 21 | r03 | Unionistas de SalamancaUnionistas de | - | ValladolidValladolid |
| 23 Jul 21 | r03 | DoncasterDoncaster | 2 - 3 | NewcastleNewcastle |
| 23 Jul 21 | r03 | PlymouthPlymouth | 1 - 2 | MiddlesbroughMiddlesbrough |
| 23 Jul 21 | r03 | WycombeWycombe | 3 - 1 | AylesburyAylesbury |
| 23 Jul 21 | r03 | AylesburyAylesbury | 1 - 3 | WycombeWycombe |
| 23 Jul 21 | r03 | Hampton & RichmondHampton & Ric | 1 - 1 | AFC WimbledonAFC Wimbledon |
| 24 Jul 21 | r03 | Jong AZJong AZ | - | FC VolendamFC Volendam |
| 24 Jul 21 | r03 | DebrecenDebrecen | - | DiosgyorDiosgyor |
| 24 Jul 21 | r03 | LeganesLeganes | - | TalaveraTalavera |
| 24 Jul 21 | r03 | Kolding IFKolding IF | - | Silkeborg IFSilkeborg IF |
| 24 Jul 21 | r03 | Skive IKSkive IK | 0 - 2 | Aarhus FremadAarhus Fremad |
| 24 Jul 21 | r03 | WatfordWatford | 1 - 3 | BrentfordBrentford |
| 24 Jul 21 | r03 | CliftonvilleCliftonville | 2 - 0 | Newry City AFCNewry City AF |
| 24 Jul 21 | r03 | ColeraineColeraine | 0 - 2 | Annagh UnitedAnnagh United |
| 24 Jul 21 | r03 | LecceLecce | 0 - 0 | Legnago SalusLegnago Salus |
| 24 Jul 21 | r03 | TrentoTrento | 2 - 4 | Parma Calcio 1913Parma Calcio |
| 24 Jul 21 | r03 | Real AvilésReal Avilés | 0 - 1 | Real OviedoReal Oviedo |
| 24 Jul 21 | r03 | JastrzębieJastrzębie | 2 - 5 | Tychy 71Tychy 71 |
| 24 Jul 21 | r03 | GetafeGetafe | 3 - 0 | AtromitosAtromitos |
| 24 Jul 21 | r03 | Tychy 71Tychy 71 | - | JastrzębieJastrzębie |
| 24 Jul 21 | r03 | Real Sociedad BReal Sociedad | 1 - 2 | EibarEibar |
| 24 Jul 21 | r03 | NantesNantes | 3 - 1 | BrestBrest |
| 24 Jul 21 | r03 | Paksi FCPaksi FC | 2 - 0 | Budafoki MTEBudafoki MTE |
| 24 Jul 21 | r03 | Ath BilbaoAth Bilbao | 0 - 1 | MirandesMirandes |
| 24 Jul 21 | r03 | FC Den BoschFC Den Bosch | 1 - 2 | MVV MaastrichtMVV Maastrich |
| 24 Jul 21 | r03 | De GraafschapDe Graafschap | 2 - 1 | SC TelstarSC Telstar |
| 24 Jul 21 | r03 | SC Heracles AlmeloSC Heracles A | 0 - 1 | NEC NijmegenNEC Nijmegen |
| 24 Jul 21 | r03 | Willem IIWillem II | 4 - 1 | Lierse KempenzonenLierse Kempen |
| 24 Jul 21 | r03 | HullHull | 1 - 2 | MansfieldMansfield |
| 24 Jul 21 | r03 | BromleyBromley | 4 - 0 | Ebbsfleet UnitedEbbsfleet Uni |
| 24 Jul 21 | r03 | PEC ZwollePEC Zwolle | 2 - 1 | SC CambuurSC Cambuur |
| 24 Jul 21 | r03 | Jong PSVJong PSV | 1 - 4 | Schalke 04 IISchalke 04 II |
| 24 Jul 21 | r03 | Eintracht Norderstedt 03Eintracht Nor | 3 - 0 | Greifswalder FCGreifswalder |
| 24 Jul 21 | r03 | LeamingtonLeamington | 0 - 0 | Forest Green RoversForest Green |
| 24 Jul 21 | r03 | Jong UtrechtJong Utrecht | - | Go Ahead EaglesGo Ahead Eagl |
| 24 Jul 21 | r03 | St JohnstoneSt Johnstone | 0 - 0 | Fleetwood TownFleetwood Tow |
| 24 Jul 21 | r03 | GrimsbyGrimsby | 0 - 1 | RotherhamRotherham |
| 24 Jul 21 | r03 | OldhamOldham | 0 - 2 | BurnleyBurnley |
| 24 Jul 21 | r03 | Sheffield WedsSheffield Wed | - | WrexhamWrexham |
| 24 Jul 21 | r03 | CardiffCardiff | 2 - 2 | ExeterExeter |
| 24 Jul 21 | r03 | HoffenheimHoffenheim | - | SPVGG Greuther FürthSPVGG Greuthe |
| 24 Jul 21 | r03 | Bristol CityBristol City | 3 - 1 | Milton Keynes DonsMilton Keynes |
| 24 Jul 21 | r03 | Stade de ReimsStade de Reim | 1 - 2 | LensLens |
| 24 Jul 21 | r03 | ReadingReading | 1 - 1 | CharltonCharlton |
| 24 Jul 21 | r03 | Schwarz-Weiß RehdenSchwarz-Weiß | 0 - 2 | Preußen MünsterPreußen Münst |
| 24 Jul 21 | r03 | Salford CitySalford City | 2 - 1 | DerbyDerby |
| 24 Jul 21 | r03 | MönchengladbachMönchengladba | 1 - 0 | MetzMetz |
| 24 Jul 21 | r03 | WolfsburgWolfsburg | 1 - 2 | MonacoMonaco |
| 24 Jul 21 | r03 | NorthamptonNorthampton | 3 - 2 | BirminghamBirmingham |
| 24 Jul 21 | r03 | WatfordWatford | 0 - 0 | West BromWest Brom |
| 24 Jul 21 | r03 | CelticCeltic | 2 - 6 | West HamWest Ham |
| 24 Jul 21 | r03 | DartfordDartford | 1 - 0 | AFC WimbledonAFC Wimbledon |
| 24 Jul 21 | r03 | BarrowBarrow | 0 - 1 | BoltonBolton |
| 24 Jul 21 | r03 | BurtonBurton | 0 - 0 | LeicesterLeicester |
| 24 Jul 21 | r03 | AshtonAshton | 0 - 2 | AltrinchamAltrincham |
| 24 Jul 21 | r03 | BanburyBanbury | 1 - 1 | Solihull MoorsSolihull Moor |
| 24 Jul 21 | r03 | MaidstoneMaidstone | - | SouthendSouthend |
| 24 Jul 21 | r03 | LutonLuton | 1 - 1 | PortsmouthPortsmouth |
| 24 Jul 21 | r03 | CheltenhamCheltenham | 2 - 0 | CoventryCoventry |
| 24 Jul 21 | r03 | DoverDover | 2 - 1 | Folkestone InvictaFolkestone In |
| 24 Jul 21 | r03 | Metropolitan Police FCMetropolitan | - | EastleighEastleigh |
| 24 Jul 21 | r03 | WeymouthWeymouth | 1 - 0 | SwindonSwindon |
| 24 Jul 21 | r03 | BradfordBradford | 2 - 0 | BlackburnBlackburn |
| 24 Jul 21 | r03 | DerbyDerby | 2 - 1 | Salford CitySalford City |
| 24 Jul 21 | r03 | Maidenhead UnitedMaidenhead Un | 1 - 2 | Leyton OrientLeyton Orient |
| 24 Jul 21 | r03 | IpswichIpswich | 0 - 1 | Crystal PalaceCrystal Palac |
| 24 Jul 21 | r03 | CarlisleCarlisle | 0 - 1 | BlackpoolBlackpool |
| 24 Jul 21 | r03 | Harrogate Town FCHarrogate Tow | 0 - 4 | SunderlandSunderland |
| 24 Jul 21 | r03 | ScunthorpeScunthorpe | 0 - 1 | HullHull |
| 24 Jul 21 | r03 | CreweCrewe | 2 - 2 | Nottingham F.Nottingham F. |
| 24 Jul 21 | r03 | Bristol RoversBristol Rover | - | SwanseaSwansea |
| 24 Jul 21 | r03 | BirminghamBirmingham | - | Oxford UtdOxford Utd |
| 24 Jul 21 | r03 | NiceNice | 0 - 2 | Union BerlinUnion Berlin |
| 24 Jul 21 | r03 | Warrington TownWarrington To | 0 - 1 | TranmereTranmere |
| 24 Jul 21 | r03 | AFC FyldeAFC Fylde | 0 - 1 | RochdaleRochdale |
| 24 Jul 21 | r03 | StokeStoke | 2 - 0 | Aston VillaAston Villa |
| 24 Jul 21 | r03 | HornchurchHornchurch | 0 - 3 | Dagenham & Red.Dagenham & Re |
| 24 Jul 21 | r03 | Poole Town F.CPoole Town F. | 0 - 2 | TorquayTorquay |
| 24 Jul 21 | r03 | L.R. Vicenza VirtusL.R. Vicenza | 0 - 3 | CagliariCagliari |
| 24 Jul 21 | r03 | Ein FrankfurtEin Frankfurt | 2 - 3 | StrasbourgStrasbourg |
| 24 Jul 21 | r03 | Stratford TownStratford Tow | 0 - 1 | YeovilYeovil |
| 24 Jul 21 | r03 | BolognaBologna | 1 - 0 | FeralpisalòFeralpisalò |
| 24 Jul 21 | r03 | AngersAngers | 3 - 0 | TroyesTroyes |
| 24 Jul 21 | r03 | BochumBochum | - | TorinoTorino |
| 24 Jul 21 | r03 | GyorGyor | 1 - 1 | Kisvárda FCKisvárda FC |
| 24 Jul 21 | r03 | WesterloWesterlo | 1 - 0 | OFIOFI |
| 24 Jul 21 | r03 | FC KolnFC Koln | 2 - 1 | ElversbergElversberg |
| 24 Jul 21 | r03 | Chrobry GłogówChrobry Głogó | - | Miedz LegnicaMiedz Legnica |
| 24 Jul 21 | r03 | VeronaVerona | 0 - 0 | Virtus VeronaVirtus Verona |
| 24 Jul 21 | r03 | BordeauxBordeaux | 1 - 1 | LorientLorient |
| 24 Jul 21 | r03 | Miedz LegnicaMiedz Legnica | 2 - 0 | Chrobry GłogówChrobry Głogó |
| 24 Jul 21 | r03 | SassuoloSassuolo | 0 - 0 | SudtirolSudtirol |
| 24 Jul 21 | r03 | LevanteLevante | 3 - 1 | RennesRennes |
| 24 Jul 21 | r03 | Sutton UnitedSutton United | 1 - 2 | AldershotAldershot |
| 24 Jul 21 | r03 | St EtienneSt Etienne | 2 - 3 | Clermont FootClermont Foot |
| 24 Jul 21 | r03 | FC UtrechtFC Utrecht | 6 - 2 | NFC VolosNFC Volos |
| 24 Jul 21 | r03 | RennesRennes | 1 - 3 | LevanteLevante |
| 24 Jul 21 | r03 | RangersRangers | 0 - 0 | BrightonBrighton |
| 24 Jul 21 | r03 | UD IbizaUD Ibiza | 1 - 2 | MallorcaMallorca |
| 24 Jul 21 | r03 | SociedadSociedad | 3 - 1 | AlavesAlaves |
| 24 Jul 21 | r03 | ValenciaValencia | 3 - 2 | Cartagena FCCartagena FC |
| 24 Jul 21 | r03 | MalagaMalaga | 2 - 0 | Sevilla AtleticoSevilla Atlet |
| 24 Jul 21 | r03 | BetisBetis | 0 - 1 | WolvesWolves |
| 24 Jul 21 | r03 | Kispest HonvedKispest Honve | - | VillarrealVillarreal |
| 24 Jul 21 | r03 | PonferradinaPonferradina | - | ValladolidValladolid |
| 24 Jul 21 | r03 | Algeciras CFAlgeciras CF | 0 - 4 | CadizCadiz |
| 24 Jul 21 | r03 | F.C. Paços de FerreiraF.C. Paços de | 2 - 1 | BragaBraga |
| 24 Jul 21 | r03 | ElcheElche | - | ZaragozaZaragoza |
| 25 Jul 21 | r03 | AZ AlkmaarAZ Alkmaar | - | PanetolikosPanetolikos |
| 25 Jul 21 | r03 | Pordenone CalcioPordenone Cal | 2 - 1 | GoricaGorica |
| 25 Jul 21 | r03 | Anorthosis FamagustaAnorthosis Fa | 2 - 0 | Doxa KatokopiasDoxa Katokopi |
| 25 Jul 21 | r03 | ÁguilasÁguilas | 0 - 1 | AlmeriaAlmeria |
| 25 Jul 21 | r03 | Hannover IIHannover II | 2 - 0 | Teutonia OttensenTeutonia Otte |
| 25 Jul 21 | r03 | FC EmmenFC Emmen | 4 - 1 | SC Heracles AlmeloSC Heracles A |
| 25 Jul 21 | r03 | III Kerületi TVEIII Kerületi | 1 - 2 | Újpest FCÚjpest FC |
| 25 Jul 21 | r03 | FC PortoFC Porto | 2 - 0 | LilleLille |
| 25 Jul 21 | r03 | Sporting CPSporting CP | 3 - 2 | LyonLyon |
| 25 Jul 21 | r03 | BenficaBenfica | 1 - 1 | MarseilleMarseille |
| 26 Jul 21 | r03 | ChelmsfordChelmsford | 1 - 1 | Kings Lynn TownKings Lynn To |
| 27 Jul 21 | r03 | Apoel NicosiaApoel Nicosia | - | CSKA SofiaCSKA Sofia |
| 27 Jul 21 | r03 | FC AndorraFC Andorra | 0 - 1 | UD IbizaUD Ibiza |
| 27 Jul 21 | r03 | Pirin BlagoevgradPirin Blagoev | 0 - 4 | Apoel NicosiaApoel Nicosia |
| 27 Jul 21 | r03 | Al NasrAl Nasr | 1 - 1 | Cartagena FCCartagena FC |
| 27 Jul 21 | r03 | ExeterExeter | 0 - 4 | Bristol CityBristol City |
| 27 Jul 21 | r03 | GenkGenk | 1 - 3 | MolenbeekMolenbeek |
| 27 Jul 21 | r03 | TorinoTorino | 0 - 0 | Al Fateh FCAl Fateh FC |
| 27 Jul 21 | r03 | LazioLazio | 1 - 1 | Calcio PadovaCalcio Padova |
| 27 Jul 21 | r03 | Rijnsburgse BoysRijnsburgse B | 1 - 2 | SC TelstarSC Telstar |
| 27 Jul 21 | r03 | LevanteLevante | 2 - 1 | AtromitosAtromitos |
| 27 Jul 21 | r03 | NAC BredaNAC Breda | 1 - 2 | Almere City FCAlmere City F |
| 27 Jul 21 | r03 | PlymouthPlymouth | 0 - 1 | Bristol CityBristol City |
| 27 Jul 21 | r03 | Crystal PalaceCrystal Palac | 2 - 2 | CharltonCharlton |
| 27 Jul 21 | r03 | De TreffersDe Treffers | 0 - 0 | De GraafschapDe Graafschap |
| 27 Jul 21 | r03 | Havant & WaterloovilleHavant & Wate | - | Bristol RoversBristol Rover |
| 27 Jul 21 | r03 | GillinghamGillingham | 1 - 1 | MillwallMillwall |
| 27 Jul 21 | r03 | MansfieldMansfield | 1 - 0 | CoventryCoventry |
| 27 Jul 21 | r03 | Cambridge UnitedCambridge Uni | 1 - 2 | QPRQPR |
| 27 Jul 21 | r03 | OldhamOldham | 2 - 1 | CreweCrewe |
| 27 Jul 21 | r03 | RotherhamRotherham | 1 - 1 | NewcastleNewcastle |
| 27 Jul 21 | r03 | Fleetwood TownFleetwood Tow | 2 - 1 | Huddersfield TownHuddersfield |
| 27 Jul 21 | r03 | TranmereTranmere | 0 - 0 | SunderlandSunderland |
| 27 Jul 21 | r03 | Brackley TownBrackley Town | - | NorthamptonNorthampton |
| 27 Jul 21 | r03 | CardiffCardiff | 0 - 4 | SouthamptonSouthampton |
| 27 Jul 21 | r03 | Bristol RoversBristol Rover | 0 - 0 | Havant & WaterloovilleHavant & Wate |
| 27 Jul 21 | r03 | Darlington F.C.Darlington F. | 1 - 5 | Harrogate Town FCHarrogate Tow |
| 27 Jul 21 | r03 | DartfordDartford | 3 - 1 | Sutton UnitedSutton United |
| 27 Jul 21 | r03 | WokingWoking | 1 - 0 | AFC WimbledonAFC Wimbledon |
| 27 Jul 21 | r03 | Wimborne TownWimborne Town | 1 - 1 | EastleighEastleigh |
| 27 Jul 21 | r03 | ChesterfieldChesterfield | 2 - 1 | BradfordBradford |
| 27 Jul 21 | r03 | GuiseleyGuiseley | 2 - 3 | LeedsLeeds |
| 27 Jul 21 | r03 | ScunthorpeScunthorpe | 0 - 2 | LincolnLincoln |
| 27 Jul 21 | r03 | BarnetBarnet | - | SwindonSwindon |
| 27 Jul 21 | r03 | WiganWigan | 2 - 1 | StokeStoke |
| 27 Jul 21 | r03 | WalsallWalsall | - | West BromWest Brom |
| 27 Jul 21 | r03 | Port ValePort Vale | 1 - 2 | Sheffield WedsSheffield Wed |
| 27 Jul 21 | r03 | Hungerford TownHungerford To | - | CheltenhamCheltenham |
| 27 Jul 21 | r03 | Warrington TownWarrington To | 0 - 2 | AccringtonAccrington |
| 27 Jul 21 | r03 | Chesham UnitedChesham Unite | 1 - 4 | WealdstoneWealdstone |
| 27 Jul 21 | r03 | ColchesterColchester | 3 - 3 | IpswichIpswich |
| 27 Jul 21 | r03 | Enfield TownEnfield Town | 1 - 4 | Boreham WoodBoreham Wood |
| 27 Jul 21 | r03 | StevenageStevenage | 1 - 1 | WatfordWatford |
| 27 Jul 21 | r03 | Farsley CelticFarsley Celti | 0 - 0 | HalifaxHalifax |
| 27 Jul 21 | r03 | Nantwich TownNantwich Town | 0 - 3 | AltrinchamAltrincham |
| 27 Jul 21 | r03 | CurzonCurzon | 0 - 1 | Salford CitySalford City |
| 27 Jul 21 | r03 | Alfreton TownAlfreton Town | 2 - 1 | BurtonBurton |
| 27 Jul 21 | r03 | Boston United FCBoston United | 1 - 3 | Notts CountyNotts County |
| 27 Jul 21 | r03 | HerefordHereford | 1 - 8 | CheltenhamCheltenham |
| 27 Jul 21 | r03 | Haringey BoroughHaringey Boro | 0 - 0 | AldershotAldershot |
| 27 Jul 21 | r03 | BlackpoolBlackpool | 0 - 1 | BurnleyBurnley |
| 27 Jul 21 | r03 | TorquayTorquay | 3 - 0 | Truro CityTruro City |
| 28 Jul 21 | r03 | OnisilosOnisilos | 1 - 6 | Olympiakos NicosiaOlympiakos Ni |
| 28 Jul 21 | r03 | AEK LarnacaAEK Larnaca | 0 - 0 | DhamkDhamk |
| 28 Jul 21 | r03 | SD AmorebietaSD Amorebieta | 0 - 1 | OsasunaOsasuna |
| 28 Jul 21 | r03 | LeonesaLeonesa | 2 - 1 | Real OviedoReal Oviedo |
| 28 Jul 21 | r03 | AlcorconAlcorcon | - | CrotoneCrotone |
| 28 Jul 21 | r03 | Pafos FCPafos FC | 2 - 0 | CoruxoCoruxo |
| 28 Jul 21 | r03 | Casa PiaCasa Pia | 0 - 0 | União de SantarémUnião de Sant |
| 28 Jul 21 | r03 | Omonia NicosiaOmonia Nicosi | 5 - 1 | Olympiada LympionOlympiada Lym |
| 28 Jul 21 | r03 | Oxford UtdOxford Utd | 2 - 2 | PeterboroPeterboro |
| 28 Jul 21 | r03 | Aston VillaAston Villa | - | Nottingham F.Nottingham F. |
| 28 Jul 21 | r03 | AZ AlkmaarAZ Alkmaar | 2 - 0 | OFIOFI |
| 28 Jul 21 | r03 | LeverkusenLeverkusen | 1 - 5 | FC UtrechtFC Utrecht |
| 28 Jul 21 | r03 | NantesNantes | 0 - 1 | LorientLorient |
| 28 Jul 21 | r03 | Doxa KatokopiasDoxa Katokopi | 2 - 0 | KarmiotissaKarmiotissa |
| 28 Jul 21 | r03 | TroyesTroyes | 1 - 2 | MetzMetz |
| 28 Jul 21 | r03 | SociedadSociedad | 2 - 1 | MonacoMonaco |
| 28 Jul 21 | r03 | ValenciaValencia | 0 - 2 | ZaragozaZaragoza |
| 28 Jul 21 | r03 | LeganesLeganes | 2 - 1 | Rayo MajadahondaRayo Majadaho |
| 28 Jul 21 | r03 | Stade PlabennécoisStade Plabenn | 2 - 4 | BrestBrest |
| 28 Jul 21 | r03 | ElcheElche | 2 - 2 | TenerifeTenerife |
| 28 Jul 21 | r03 | Forest Green RoversForest Green | 1 - 2 | SwanseaSwansea |
| 28 Jul 21 | r03 | DerbyDerby | 1 - 0 | BetisBetis |
| 28 Jul 21 | r03 | DoncasterDoncaster | 0 - 4 | Sheffield UnitedSheffield Uni |
| 28 Jul 21 | r03 | Basford Utd.Basford Utd. | 0 - 3 | MansfieldMansfield |
| 28 Jul 21 | r03 | WycombeWycombe | 1 - 0 | LeicesterLeicester |
| 28 Jul 21 | r03 | BlackburnBlackburn | 1 - 1 | LeedsLeeds |
| 28 Jul 21 | r03 | Lancaster CityLancaster Cit | - | CarlisleCarlisle |
| 28 Jul 21 | r03 | St EtienneSt Etienne | 1 - 2 | MarseilleMarseille |
| 29 Jul 21 | r03 | Apoel NicosiaApoel Nicosia | 0 - 0 | Al Nassr FCAl Nassr FC |
| 29 Jul 21 | r03 | WiedenbrückWiedenbrück | 1 - 1 | Schwarz-Weiß RehdenSchwarz-Weiß |
| 29 Jul 21 | r03 | RödinghausenRödinghausen | - | Jong UtrechtJong Utrecht |
| 29 Jul 21 | r03 | Jong UtrechtJong Utrecht | 1 - 3 | TOP OssTOP Oss |
| 29 Jul 21 | r03 | BochumBochum | 1 - 2 | VitesseVitesse |
| 29 Jul 21 | r03 | Apoel NicosiaApoel Nicosia | - | Al NasrAl Nasr |
| 29 Jul 21 | r03 | FiorentinaFiorentina | 9 - 0 | US Levico TermeUS Levico Ter |
| 30 Jul 21 | r03 | Jong AZJong AZ | - | StandardStandard |
| 30 Jul 21 | r03 | Parma Calcio 1913Parma Calcio | - | Giana ErminioGiana Erminio |
| 30 Jul 21 | r03 | FC Den BoschFC Den Bosch | 0 - 1 | SV TECSV TEC |
| 30 Jul 21 | r03 | Las PalmasLas Palmas | 5 - 0 | UD San FernandoUD San Fernan |
| 30 Jul 21 | r03 | StraelenStraelen | 3 - 4 | Fortuna SittardFortuna Sitta |
| 30 Jul 21 | r03 | FC DordrechtFC Dordrecht | 0 - 0 | Fortuna SittardFortuna Sitta |
| 30 Jul 21 | r03 | FiorentinaFiorentina | 4 - 0 | Virtus VeronaVirtus Verona |
| 30 Jul 21 | r03 | SC Heracles AlmeloSC Heracles A | 4 - 1 | RKC WaalwijkRKC Waalwijk |
| 30 Jul 21 | r03 | NEC NijmegenNEC Nijmegen | 2 - 0 | OFIOFI |
| 30 Jul 21 | r03 | ZaragozaZaragoza | 1 - 1 | AtromitosAtromitos |
| 30 Jul 21 | r03 | FC Den BoschFC Den Bosch | - | Helmond SportHelmond Sport |
| 30 Jul 21 | r03 | FC EindhovenFC Eindhoven | 0 - 2 | Lierse KempenzonenLierse Kempen |
| 30 Jul 21 | r03 | SSV JeddelohSSV Jeddeloh | 0 - 3 | Atlas DelmenhorstAtlas Delmenh |
| 30 Jul 21 | r03 | ValladolidValladolid | - | OsasunaOsasuna |
| 30 Jul 21 | r03 | LevanteLevante | 1 - 0 | ValenciaValencia |
| 30 Jul 21 | r03 | SC CambuurSC Cambuur | - | FC EmmenFC Emmen |
| 30 Jul 21 | r03 | NAC BredaNAC Breda | 1 - 0 | Lommel SKLommel SK |
| 30 Jul 21 | r03 | FuenlabradaFuenlabrada | 0 - 1 | GetafeGetafe |
| 30 Jul 21 | r03 | Fleetwood TownFleetwood Tow | 2 - 1 | LeedsLeeds |
| 30 Jul 21 | r03 | CarlisleCarlisle | 3 - 0 | HalifaxHalifax |
| 30 Jul 21 | r03 | RotherhamRotherham | 0 - 1 | MiddlesbroughMiddlesbrough |
| 30 Jul 21 | r03 | HullHull | 2 - 1 | SunderlandSunderland |
| 30 Jul 21 | r03 | WiganWigan | 3 - 2 | PrestonPreston |
| 30 Jul 21 | r03 | Bamber BridgeBamber Bridge | - | BlackpoolBlackpool |
| 30 Jul 21 | r03 | KnockbredaKnockbreda | 2 - 2 | PortadownPortadown |
| 30 Jul 21 | r03 | BurtonBurton | 0 - 2 | NewcastleNewcastle |
| 30 Jul 21 | r03 | AveleyAveley | 0 - 5 | Dagenham & Red.Dagenham & Re |
| 31 Jul 21 | r03 | EmpoliEmpoli | - | Montevarchi Calcio AquilaMontevarchi C |
| 31 Jul 21 | r03 | TroyesTroyes | - | StrasbourgStrasbourg |
| 31 Jul 21 | r03 | Jong AZJong AZ | - | St. GilloiseSt. Gilloise |
| 31 Jul 21 | r03 | LeganesLeganes | 0 - 1 | Real Madrid BReal Madrid B |
| 31 Jul 21 | r03 | Doxa KatokopiasDoxa Katokopi | - | Aris LimassolAris Limassol |
| 31 Jul 21 | r03 | Sutton UnitedSutton United | 2 - 1 | BarnetBarnet |
| 31 Jul 21 | r03 | TranmereTranmere | 1 - 2 | BurnleyBurnley |
| 31 Jul 21 | r03 | LeverkusenLeverkusen | 3 - 1 | Rot-Weiß OberhausenRot-Weiß Ober |
| 31 Jul 21 | r03 | Dungannon SwiftsDungannon Swi | 4 - 1 | H and W WeldersH and W Welde |
| 31 Jul 21 | r03 | VVV-VenloVVV-Venlo | 2 - 2 | PanathinaikosPanathinaikos |
| 31 Jul 21 | r03 | TamworthTamworth | 0 - 5 | WrexhamWrexham |
| 31 Jul 21 | r03 | SwindonSwindon | 0 - 1 | PeterboroPeterboro |
| 31 Jul 21 | r03 | CrusadersCrusaders | 3 - 1 | LoughgallLoughgall |
| 31 Jul 21 | r03 | Pro PatriaPro Patria | 0 - 1 | AlessandriaAlessandria |
| 31 Jul 21 | r03 | StrasbourgStrasbourg | 2 - 1 | FreiburgFreiburg |
| 31 Jul 21 | r03 | MalagaMalaga | 1 - 1 | AlmeriaAlmeria |
| 31 Jul 21 | r03 | Go Ahead EaglesGo Ahead Eagl | 1 - 2 | FC EmmenFC Emmen |
| 31 Jul 21 | r03 | TroyesTroyes | 1 - 1 | BordeauxBordeaux |
| 31 Jul 21 | r03 | Sparta NijkerkSparta Nijker | - | Go Ahead EaglesGo Ahead Eagl |
| 31 Jul 21 | r03 | Almere City FCAlmere City F | 0 - 1 | FC GroningenFC Groningen |
| 31 Jul 21 | r03 | DoverDover | 0 - 2 | StevenageStevenage |
| 31 Jul 21 | r03 | Staines TownStaines Town | - | Maidenhead UnitedMaidenhead Un |
| 31 Jul 21 | r03 | SC Heracles AlmeloSC Heracles A | 2 - 2 | De GraafschapDe Graafschap |
| 31 Jul 21 | r03 | Sutton UnitedSutton United | - | SwindonSwindon |
| 31 Jul 21 | r03 | Bristol CityBristol City | 0 - 3 | Aston VillaAston Villa |
| 31 Jul 21 | r03 | Huddersfield TownHuddersfield | - | CreweCrewe |
| 31 Jul 21 | r03 | WesterloWesterlo | - | PanathinaikosPanathinaikos |
| 31 Jul 21 | r03 | Ballymena UnitedBallymena Uni | 0 - 2 | InstituteInstitute |
| 31 Jul 21 | r03 | RödinghausenRödinghausen | - | OldenburgOldenburg |
| 31 Jul 21 | r03 | Schalke 04 IISchalke 04 II | 0 - 2 | Hannover IIHannover II |
| 31 Jul 21 | r03 | CardiffCardiff | 2 - 0 | NewportNewport |
| 31 Jul 21 | r03 | Bristol RoversBristol Rover | 3 - 2 | Oxford UtdOxford Utd |
| 31 Jul 21 | r03 | StokeStoke | 1 - 1 | WolvesWolves |
| 31 Jul 21 | r03 | BielefeldBielefeld | 1 - 1 | FC TwenteFC Twente |
| 31 Jul 21 | r03 | ExcelsiorExcelsior | 0 - 3 | SpartaSparta |
| 31 Jul 21 | r03 | MönchengladbachMönchengladba | 2 - 1 | FC GroningenFC Groningen |
| 31 Jul 21 | r03 | Leyton OrientLeyton Orient | 2 - 0 | GillinghamGillingham |
| 31 Jul 21 | r03 | Brightlingsea RegentBrightlingsea | 0 - 5 | AltrinchamAltrincham |
| 31 Jul 21 | r03 | FC VolendamFC Volendam | 4 - 2 | Jong AjaxJong Ajax |
| 31 Jul 21 | r03 | QPRQPR | 3 - 3 | LeicesterLeicester |
| 31 Jul 21 | r03 | AccringtonAccrington | 0 - 2 | BradfordBradford |
| 31 Jul 21 | r03 | AngersAngers | 1 - 0 | LorientLorient |
| 31 Jul 21 | r03 | Union BerlinUnion Berlin | 2 - 1 | Ath BilbaoAth Bilbao |
| 31 Jul 21 | r03 | AugsburgAugsburg | 3 - 1 | CagliariCagliari |
| 31 Jul 21 | r03 | HoffenheimHoffenheim | 3 - 1 | Stade de ReimsStade de Reim |
| 31 Jul 21 | r03 | AFC WimbledonAFC Wimbledon | 1 - 2 | ScunthorpeScunthorpe |
| 31 Jul 21 | r03 | BoltonBolton | 2 - 2 | BlackburnBlackburn |
| 31 Jul 21 | r03 | CheltenhamCheltenham | 2 - 0 | WalsallWalsall |
| 31 Jul 21 | r03 | IpswichIpswich | 0 - 3 | MillwallMillwall |
| 31 Jul 21 | r03 | Chester CityChester City | 3 - 0 | Fleetwood TownFleetwood Tow |
| 31 Jul 21 | r03 | PortsmouthPortsmouth | 2 - 0 | PeterboroPeterboro |
| 31 Jul 21 | r03 | YeovilYeovil | 0 - 1 | Forest Green RoversForest Green |
| 31 Jul 21 | r03 | WealdstoneWealdstone | 1 - 1 | ColchesterColchester |
| 31 Jul 21 | r03 | DartfordDartford | 2 - 2 | SouthendSouthend |
| 31 Jul 21 | r03 | Cambridge UnitedCambridge Uni | 0 - 0 | NorthamptonNorthampton |
| 31 Jul 21 | r03 | Alfreton TownAlfreton Town | 1 - 2 | Solihull MoorsSolihull Moor |
| 31 Jul 21 | r03 | MorecambeMorecambe | 1 - 1 | BlackpoolBlackpool |
| 31 Jul 21 | r03 | SouthportSouthport | 2 - 1 | BarrowBarrow |
| 31 Jul 21 | r03 | Salford CitySalford City | 0 - 2 | LincolnLincoln |
| 31 Jul 21 | r03 | Dorchester TownDorchester To | 2 - 5 | WeymouthWeymouth |
| 31 Jul 21 | r03 | CurzonCurzon | 0 - 4 | StockportStockport |
| 31 Jul 21 | r03 | BirminghamBirmingham | 0 - 4 | West BromWest Brom |
| 31 Jul 21 | r03 | Nottingham F.Nottingham F. | - | BurnleyBurnley |
| 31 Jul 21 | r03 | SwanseaSwansea | 1 - 3 | SouthamptonSouthampton |
| 31 Jul 21 | r03 | Sheffield UnitedSheffield Uni | - | NorwichNorwich |
| 31 Jul 21 | r03 | TorquayTorquay | 0 - 3 | PlymouthPlymouth |
| 31 Jul 21 | r03 | Banbridge TownBanbridge Tow | 0 - 5 | Carrick RangersCarrick Range |
| 31 Jul 21 | r03 | Hemel Hempstead Town FCHemel Hempste | 0 - 3 | Dagenham & Red.Dagenham & Re |
| 31 Jul 21 | r03 | Kings LangleyKings Langley | 0 - 5 | Boreham WoodBoreham Wood |
| 31 Jul 21 | r03 | Stratford TownStratford Tow | 0 - 2 | Kings Lynn TownKings Lynn To |
| 31 Jul 21 | r03 | FarnboroughFarnborough | 1 - 1 | Maidenhead UnitedMaidenhead Un |
| 31 Jul 21 | r03 | AZ AlkmaarAZ Alkmaar | 1 - 0 | SociedadSociedad |
| 31 Jul 21 | r03 | WatfordWatford | - | BarnsleyBarnsley |
| 31 Jul 21 | r03 | FulhamFulham | 1 - 0 | CharltonCharlton |
| 31 Jul 21 | r03 | Huddersfield TownHuddersfield | - | OldhamOldham |
| 31 Jul 21 | r03 | SPVGG Greuther FürthSPVGG Greuthe | - | EibarEibar |
| 31 Jul 21 | r03 | MainzMainz | 3 - 2 | GenoaGenoa |
| 31 Jul 21 | r03 | PEC ZwollePEC Zwolle | 0 - 2 | SC HeerenveenSC Heerenveen |
| 31 Jul 21 | r03 | MVV MaastrichtMVV Maastrich | - | Lommel SKLommel SK |
| 31 Jul 21 | r03 | MetzMetz | 1 - 0 | MontpellierMontpellier |
| 31 Jul 21 | r03 | RennesRennes | 1 - 0 | TorinoTorino |
| 31 Jul 21 | r03 | Lommel SKLommel SK | 1 - 2 | MVV MaastrichtMVV Maastrich |
| 31 Jul 21 | r03 | TenerifeTenerife | 0 - 0 | Cartagena FCCartagena FC |
| 31 Jul 21 | r03 | AlavesAlaves | 0 - 1 | ElcheElche |
| 31 Jul 21 | r03 | Real Sociedad BReal Sociedad | 0 - 0 | BurgosBurgos |
| 31 Jul 21 | r03 | Go Ahead EaglesGo Ahead Eagl | - | Willem IIWillem II |
| 31 Jul 21 | r03 | MarseilleMarseille | 2 - 1 | VillarrealVillarreal |
| 01 Aug 21 | r03 | Almere City FCAlmere City F | 1 - 1 | WesterloWesterlo |
| 01 Aug 21 | r03 | CrotoneCrotone | 1 - 0 | Giana ErminioGiana Erminio |
| 01 Aug 21 | r03 | SSD PalermoSSD Palermo | 1 - 2 | SalernitanaSalernitana |
| 01 Aug 21 | r03 | RKVV DEMRKVV DEM | 1 - 1 | SC TelstarSC Telstar |
| 01 Aug 21 | r03 | DerbyDerby | 0 - 2 | Notts CountyNotts County |
| 01 Aug 21 | r03 | CoventryCoventry | 1 - 2 | WolvesWolves |
| 01 Aug 21 | r03 | SC TelstarSC Telstar | 1 - 1 | RKVV DEMRKVV DEM |
| 01 Aug 21 | r03 | FeyenoordFeyenoord | 1 - 1 | ADO Den HaagADO Den Haag |
| 01 Aug 21 | r03 | Lüneburger SK HansaLüneburger SK | - | Holstein Kiel IIHolstein Kiel |
| 01 Aug 21 | r03 | BrestBrest | 1 - 2 | MallorcaMallorca |
| 02 Aug 21 | r03 | GranadaGranada | 3 - 0 | LinenseLinense |
| 02 Aug 21 | r03 | StandardStandard | - | MolenbeekMolenbeek |
| 03 Aug 21 | r03 | SpeziaSpezia | - | TrentoTrento |
| 03 Aug 21 | r03 | Armagh CityArmagh City | 0 - 4 | Dungannon SwiftsDungannon Swi |
| 03 Aug 21 | r03 | Peña DeportivaPeña Deportiv | 2 - 0 | UD IbizaUD Ibiza |
| 03 Aug 21 | r03 | ElcheElche | 1 - 1 | Cartagena FCCartagena FC |
| 03 Aug 21 | r03 | Truro CityTruro City | 1 - 0 | ExeterExeter |
| 03 Aug 21 | r03 | Kings Lynn TownKings Lynn To | 1 - 0 | PeterboroPeterboro |
| 03 Aug 21 | r03 | Chippenham Town FCChippenham To | 2 - 2 | EastleighEastleigh |
| 03 Aug 21 | r03 | Queens UniversityQueens Univer | - | Carrick RangersCarrick Range |
| 03 Aug 21 | r03 | Taunton TownTaunton Town | 0 - 1 | YeovilYeovil |
| 03 Aug 21 | r03 | GuiseleyGuiseley | 1 - 2 | HalifaxHalifax |
| 03 Aug 21 | r03 | Alfreton TownAlfreton Town | 0 - 1 | GrimsbyGrimsby |
| 03 Aug 21 | r03 | Bradford Park AvenueBradford Park | 1 - 2 | AltrinchamAltrincham |
| 03 Aug 21 | r03 | FarnboroughFarnborough | 2 - 1 | WokingWoking |
| 03 Aug 21 | r03 | Tiverton TownTiverton Town | 1 - 3 | TorquayTorquay |
| 03 Aug 21 | r03 | NorwichNorwich | 5 - 0 | GillinghamGillingham |
| 04 Aug 21 | r03 | EmpoliEmpoli | - | CarrareseCarrarese |
| 04 Aug 21 | r03 | Pro PatriaPro Patria | 1 - 1 | MonzaMonza |
| 04 Aug 21 | r03 | FrosinoneFrosinone | - | AvellinoAvellino |
| 04 Aug 21 | r03 | LazioLazio | 1 - 1 | SV MeppenSV Meppen |
| 04 Aug 21 | r03 | Mouscron-PeruwelzMouscron-Peru | 1 - 0 | GentGent |
| 04 Aug 21 | r03 | AlmeriaAlmeria | 2 - 1 | BetisBetis |
| 04 Aug 21 | r03 | ZamoraZamora | 0 - 3 | PonferradinaPonferradina |
| 04 Aug 21 | r03 | Doxa KatokopiasDoxa Katokopi | 1 - 0 | PAEEKPAEEK |
| 04 Aug 21 | r03 | OlbiaOlbia | 0 - 3 | CagliariCagliari |
| 04 Aug 21 | r03 | SD AmorebietaSD Amorebieta | 2 - 1 | EibarEibar |
| 04 Aug 21 | r03 | LeganesLeganes | 0 - 2 | FuenlabradaFuenlabrada |
| 04 Aug 21 | r03 | SC Heracles AlmeloSC Heracles A | 7 - 0 | HSC 21HSC 21 |
| 05 Aug 21 | r03 | Las PalmasLas Palmas | 1 - 0 | Panadería PulidoPanadería Pul |
| 06 Aug 21 | r03 | AlavesAlaves | 4 - 3 | Al NasrAl Nasr |
| 06 Aug 21 | r03 | SPAL 2013SPAL 2013 | 1 - 2 | CremoneseCremonese |
| 06 Aug 21 | r03 | SociedadSociedad | 1 - 3 | OsasunaOsasuna |
| 06 Aug 21 | r03 | UdineseUdinese | 4 - 0 | A.S.D. Cjarlins MuzaneA.S.D. Cjarli |
| 06 Aug 21 | r03 | Mancha RealMancha Real | 2 - 2 | VélezVélez |
| 06 Aug 21 | r03 | AlcorconAlcorcon | 2 - 1 | UD IbizaUD Ibiza |
| 07 Aug 21 | r03 | LeedsLeeds | 2 - 2 | VillarrealVillarreal |
| 07 Aug 21 | r03 | WiedenbrückWiedenbrück | 0 - 0 | Hessen KasselHessen Kassel |
| 07 Aug 21 | r03 | ChesterfieldChesterfield | 3 - 1 | TamworthTamworth |
| 07 Aug 21 | r03 | GlenavonGlenavon | 2 - 0 | PortstewartPortstewart |
| 07 Aug 21 | r03 | CrusadersCrusaders | 4 - 0 | BangorBangor |
| 07 Aug 21 | r03 | GranadaGranada | - | CrotoneCrotone |
| 07 Aug 21 | r03 | PisaPisa | - | U.S. Fiorenzuola 1922 S.SU.S. Fiorenzu |
| 07 Aug 21 | r03 | FiorentinaFiorentina | 0 - 0 | EspanolEspanol |
| 07 Aug 21 | r03 | PonferradinaPonferradina | 1 - 0 | Real OviedoReal Oviedo |
| 07 Aug 21 | r03 | LeganesLeganes | 1 - 1 | VallecanoVallecano |
| 07 Aug 21 | r03 | GimnasticGimnastic | 2 - 1 | GironaGirona |
| 07 Aug 21 | r03 | LeganesLeganes | 2 - 0 | AlcorconAlcorcon |
| 07 Aug 21 | r03 | WolvesWolves | 0 - 1 | Celta VigoCelta Vigo |
| 07 Aug 21 | r03 | Willem IIWillem II | - | SpartaSparta |
| 07 Aug 21 | r03 | WiedenbrückWiedenbrück | 2 - 0 | Hannover IIHannover II |
| 07 Aug 21 | r03 | Club BruggeClub Brugge | 2 - 1 | WesterloWesterlo |
| 07 Aug 21 | r03 | Schwarz-Weiß RehdenSchwarz-Weiß | - | Teutonia OttensenTeutonia Otte |
| 07 Aug 21 | r03 | OldenburgOldenburg | 3 - 4 | VfB HombergVfB Homberg |
| 07 Aug 21 | r03 | NewcastleNewcastle | 3 - 0 | NorwichNorwich |
| 07 Aug 21 | r03 | Alfreton TownAlfreton Town | 4 - 1 | Kings Lynn TownKings Lynn To |
| 07 Aug 21 | r03 | Weston-super-Mare FCWeston-super- | 1 - 1 | YeovilYeovil |
| 07 Aug 21 | r03 | CurzonCurzon | 1 - 1 | AltrinchamAltrincham |
| 07 Aug 21 | r03 | AFC FyldeAFC Fylde | - | HalifaxHalifax |
| 07 Aug 21 | r03 | Ebbsfleet UnitedEbbsfleet Uni | 1 - 1 | SouthendSouthend |
| 07 Aug 21 | r03 | Dorking WanderersDorking Wande | 1 - 2 | WealdstoneWealdstone |
| 07 Aug 21 | r03 | Hemel Hempstead Town FCHemel Hempste | - | Boreham WoodBoreham Wood |
| 07 Aug 21 | r03 | Boston United FCBoston United | 0 - 1 | GrimsbyGrimsby |
| 07 Aug 21 | r03 | Tonbridge AngelsTonbridge Ang | 0 - 4 | DoverDover |
| 07 Aug 21 | r03 | SalisburySalisbury | 1 - 2 | EastleighEastleigh |
| 07 Aug 21 | r03 | LeamingtonLeamington | 0 - 2 | Solihull MoorsSolihull Moor |
| 07 Aug 21 | r03 | Notts CountyNotts County | 2 - 3 | YorkYork |
| 07 Aug 21 | r03 | SC Heracles AlmeloSC Heracles A | 3 - 1 | PEC ZwollePEC Zwolle |
| 07 Aug 21 | r03 | Wimborne TownWimborne Town | 0 - 2 | WeymouthWeymouth |
| 07 Aug 21 | r03 | DollingstownDollingstown | 0 - 2 | PortadownPortadown |
| 07 Aug 21 | r03 | Slough TownSlough Town | 1 - 2 | AldershotAldershot |
| 07 Aug 21 | r03 | GuiseleyGuiseley | 0 - 5 | StockportStockport |
| 07 Aug 21 | r03 | Hampton & RichmondHampton & Ric | 1 - 1 | WokingWoking |
| 07 Aug 21 | r03 | BillericayBillericay | 3 - 2 | Dagenham & Red.Dagenham & Re |
| 07 Aug 21 | r03 | Crystal PalaceCrystal Palac | 3 - 1 | WatfordWatford |
| 07 Aug 21 | r03 | TorquayTorquay | 3 - 0 | Chippenham Town FCChippenham To |
| 07 Aug 21 | r03 | Aston VillaAston Villa | - | SevillaSevilla |
| 07 Aug 21 | r03 | Apoel NicosiaApoel Nicosia | 1 - 1 | AEK LarnacaAEK Larnaca |
| 07 Aug 21 | r03 | Lierse KempenzonenLierse Kempen | 1 - 0 | DenderDender |
| 07 Aug 21 | r03 | Real Sociedad BReal Sociedad | 1 - 1 | MirandesMirandes |
| 07 Aug 21 | r03 | Go Ahead EaglesGo Ahead Eagl | - | RödinghausenRödinghausen |
| 07 Aug 21 | r03 | Real Madrid BReal Madrid B | 0 - 1 | FuenlabradaFuenlabrada |
| 07 Aug 21 | r03 | MallorcaMallorca | 1 - 0 | CagliariCagliari |
| 08 Aug 21 | r03 | AlmeriaAlmeria | 1 - 0 | Betis DeportivoBetis Deporti |
| 08 Aug 21 | r03 | Aston VillaAston Villa | 3 - 1 | SalernitanaSalernitana |
| 08 Aug 21 | r03 | MonzaMonza | 3 - 0 | Giana ErminioGiana Erminio |
| 08 Aug 21 | r03 | NapoliNapoli | 2 - 1 | AscoliAscoli |
| 08 Aug 21 | r03 | Ethnikos AchnaEthnikos Achn | 0 - 0 | AEK LarnacaAEK Larnaca |
| 08 Aug 21 | r03 | La CorunaLa Coruna | 1 - 2 | PonferradinaPonferradina |
| 09 Aug 21 | r03 | CliftonvilleCliftonville | 1 - 2 | Derry CityDerry City |
| 09 Aug 21 | r03 | UCDUCD | 4 - 1 | Warrenpoint TownWarrenpoint T |
| 10 Aug 21 | r03 | Apollon LimassolApollon Limas | 1 - 2 | Aris LimassolAris Limassol |
| 10 Aug 21 | r03 | SPAL 2013SPAL 2013 | 5 - 0 | U.S. AdrieseU.S. Adriese |
| 10 Aug 21 | r03 | ArisAris | 0 - 0 | AE LarissaAE Larissa |
| 10 Aug 21 | r03 | Willem IIWillem II | 2 - 1 | VirtonVirton |
| 10 Aug 21 | r03 | DollingstownDollingstown | 0 - 6 | GlenavonGlenavon |
| 10 Aug 21 | r03 | PanathinaikosPanathinaikos | 1 - 1 | Apoel NicosiaApoel Nicosia |
| 10 Aug 21 | r03 | Harrow BoroughHarrow Boroug | 0 - 4 | BarnetBarnet |
| 10 Aug 21 | r03 | East Thurrock UnitedEast Thurrock | - | Dagenham & Red.Dagenham & Re |
| 10 Aug 21 | r03 | Carrick RangersCarrick Range | 3 - 0 | Lisburn DistilleryLisburn Disti |
| 10 Aug 21 | r03 | Cartagena FCCartagena FC | 2 - 0 | MurciaMurcia |
| 11 Aug 21 | r03 | Apoel NicosiaApoel Nicosia | - | Olympiakos NicosiaOlympiakos Ni |
| 11 Aug 21 | r03 | Doxa KatokopiasDoxa Katokopi | 1 - 3 | Alki OrokliniAlki Oroklini |
| 11 Aug 21 | r03 | AtalantaAtalanta | 7 - 1 | AlessandriaAlessandria |
| 11 Aug 21 | r03 | Pafos FCPafos FC | 2 - 0 | Akritas ChlorakasAkritas Chlor |
| 11 Aug 21 | r03 | ViboneseVibonese | 0 - 2 | RegginaReggina |
| 11 Aug 21 | r03 | FC Trenkwalder AdmiraFC Trenkwalde | 1 - 5 | Al-Duhail SCAl-Duhail SC |
| 11 Aug 21 | r03 | Hitchin TownHitchin Town | 2 - 1 | Boreham WoodBoreham Wood |
| 13 Aug 21 | r03 | LamiaLamia | - | NFC VolosNFC Volos |
| 13 Aug 21 | r03 | Juventus U23Juventus U23 | 1 - 1 | ComoComo |
| 13 Aug 21 | r03 | PAEEKPAEEK | - | KarmiotissaKarmiotissa |
| 13 Aug 21 | r03 | AEK LarnacaAEK Larnaca | 3 - 3 | Olympiakos NicosiaOlympiakos Ni |
| 14 Aug 21 | r03 | NapoliNapoli | 4 - 0 | PescaraPescara |
| 14 Aug 21 | r03 | Moyola ParkMoyola Park | 0 - 1 | Ballymena UnitedBallymena Uni |
| 14 Aug 21 | r03 | Galway UnitedGalway United | 1 - 3 | Warrenpoint TownWarrenpoint T |
| 14 Aug 21 | r03 | ChesterfieldChesterfield | 2 - 1 | GrimsbyGrimsby |
| 14 Aug 21 | r03 | GlentoranGlentoran | 0 - 1 | ColeraineColeraine |
| 14 Aug 21 | r03 | Solihull MoorsSolihull Moor | 2 - 2 | Notts CountyNotts County |
| 14 Aug 21 | r03 | Carrick RangersCarrick Range | 4 - 1 | Crusaders Crusaders |
| 14 Aug 21 | r03 | WealdstoneWealdstone | 3 - 1 | Hungerford TownHungerford To |
| 14 Aug 21 | r03 | Ethnikos AchnaEthnikos Achn | 5 - 2 | Doxa KatokopiasDoxa Katokopi |
| 14 Aug 21 | r03 | Doxa KatokopiasDoxa Katokopi | 5 - 2 | Ethnikos AchnaEthnikos Achn |
| 14 Aug 21 | r03 | Apoel NicosiaApoel Nicosia | - | Pafos FCPafos FC |
| 14 Aug 21 | r03 | Apoel NicosiaApoel Nicosia | 2 - 0 | Apollon LimassolApollon Limas |
| 14 Aug 21 | r03 | Asteras TripolisAsteras Tripo | 1 - 0 | GianninaGiannina |
| 14 Aug 21 | r03 | IonikosIonikos | 1 - 1 | AtromitosAtromitos |
| 14 Aug 21 | r03 | ArisAris | 4 - 3 | NFC VolosNFC Volos |
| 14 Aug 21 | r03 | LazioLazio | 1 - 1 | SassuoloSassuolo |
| 14 Aug 21 | r03 | Pafos FCPafos FC | 1 - 1 | Aris LimassolAris Limassol |
| 14 Aug 21 | r03 | AEKAEK | 1 - 0 | LamiaLamia |
| 16 Aug 21 | r03 | Club BruggeClub Brugge | 7 - 2 | KMSK DeinzeKMSK Deinze |
| 17 Aug 21 | r03 | ColeraineColeraine | 0 - 1 | PortadownPortadown |
| 17 Aug 21 | r03 | CliftonvilleCliftonville | 1 - 0 | Dungannon SwiftsDungannon Swi |
| 17 Aug 21 | r03 | Carrick RangersCarrick Range | 3 - 0 | Ballyclare ComradesBallyclare Co |
| 17 Aug 21 | r03 | GlentoranGlentoran | 4 - 0 | Warrenpoint TownWarrenpoint T |
| 20 Aug 21 | r03 | CliftonvilleCliftonville | 3 - 0 | PortadownPortadown |
| 21 Aug 21 | r03 | ArisAris | 4 - 1 | GianninaGiannina |
| 21 Aug 21 | r03 | DollingstownDollingstown | - | ColeraineColeraine |
| 21 Aug 21 | r03 | GlentoranGlentoran | 3 - 1 | CrusadersCrusaders |
| 27 Aug 21 | r03 | AEL LimassolAEL Limassol | - | AEZAEZ |
| 27 Aug 21 | r03 | Olympiada LympionOlympiada Lym | 0 - 1 | Doxa KatokopiasDoxa Katokopi |
| 28 Aug 21 | r03 | AEL LimassolAEL Limassol | - | Achyronas LiopetriouAchyronas Lio |
| 28 Aug 21 | r03 | PanioniosPanionios | 1 - 1 | IonikosIonikos |
| 28 Aug 21 | r03 | ArisAris | 1 - 1 | LamiaLamia |
| 28 Aug 21 | r03 | PanathinaikosPanathinaikos | 1 - 1 | Asteras TripolisAsteras Tripo |
| 29 Aug 21 | r03 | NFC VolosNFC Volos | 4 - 3 | AEKAEK |
| 29 Aug 21 | r03 | Apoel NicosiaApoel Nicosia | 1 - 2 | XylotymbouXylotymbou |
| 31 Aug 21 | r03 | NumanciaNumancia | 1 - 1 | OsasunaOsasuna |
| 01 Sep 21 | r03 | WolfsburgWolfsburg | 3 - 3 | HannoverHannover |
| 01 Sep 21 | r03 | Dunav RuseDunav Ruse | 0 - 0 | Cherno MoreCherno More |
| 01 Sep 21 | r03 | Lichtenberg 47Lichtenberg 4 | 0 - 2 | Union BerlinUnion Berlin |
| 01 Sep 21 | r03 | Shooting StarsShooting Star | 4 - 0 | Tabor SežanaTabor Sežana |
| 02 Sep 21 | r03 | Lask Juniors LinzLask Juniors | 3 - 7 | LASKLASK |
| 02 Sep 21 | r03 | MainzMainz | 0 - 0 | KarlsruheKarlsruhe |
| 02 Sep 21 | r03 | Fortuna DüsseldorfFortuna Düsse | 1 - 0 | St.TruidenSt.Truiden |
| 02 Sep 21 | r03 | FC UtrechtFC Utrecht | 3 - 1 | Cercle BruggeCercle Brugge |
| 02 Sep 21 | r03 | StuttgartStuttgart | 3 - 0 | NurnbergNurnberg |
| 02 Sep 21 | r03 | NK Istra 1961NK Istra 1961 | 0 - 1 | OpatijaOpatija |
| 02 Sep 21 | r03 | ŠKF SereďŠKF Sereď | 2 - 0 | Floridsdorfer ACFloridsdorfer |
| 02 Sep 21 | r03 | Austria LustenauAustria Luste | 0 - 4 | St. GallenSt. Gallen |
| 02 Sep 21 | r03 | SK Vorwarts SteyrSK Vorwarts S | 0 - 3 | SKU AmstettenSKU Amstetten |
| 03 Sep 21 | r03 | Kisvárda FCKisvárda FC | 2 - 1 | Veres RivneVeres Rivne |
| 03 Sep 21 | r03 | BragaBraga | 3 - 2 | VillarrealVillarreal |
| 03 Sep 21 | r03 | PardubicePardubice | 2 - 1 | VlašimVlašim |
| 03 Sep 21 | r03 | Górnik PolkowiceGórnik Polkow | 2 - 0 | Chrobry GłogówChrobry Głogó |
| 03 Sep 21 | r03 | Stal MielecStal Mielec | 1 - 0 | NiecieczaNieciecza |
| 03 Sep 21 | r03 | ToulouseToulouse | 3 - 2 | Pau FCPau FC |
| 03 Sep 21 | r03 | Kispest HonvedKispest Honve | 0 - 1 | Budafoki MTEBudafoki MTE |
| 03 Sep 21 | r03 | Slask WroclawSlask Wroclaw | 2 - 3 | Tychy 71Tychy 71 |
| 03 Sep 21 | r03 | Dynamo DresdenDynamo Dresde | 4 - 0 | Ústí nad LabemÚstí nad Labe |
| 03 Sep 21 | r03 | SC Rheindorf AltachSC Rheindorf | 1 - 3 | VaduzVaduz |
| 03 Sep 21 | r03 | BrestBrest | 2 - 4 | GuingampGuingamp |
| 03 Sep 21 | r03 | TSC Bačka TopolaTSC Bačka Top | 2 - 1 | FerencvarosFerencvaros |
| 03 Sep 21 | r03 | Sturm GrazSturm Graz | 1 - 1 | NK BravoNK Bravo |
| 03 Sep 21 | r03 | GrasshoppersGrasshoppers | 5 - 2 | DornbirnDornbirn |
| 03 Sep 21 | r03 | Slavia SofiaSlavia Sofia | 0 - 1 | Botev PlovdivBotev Plovdiv |
| 03 Sep 21 | r03 | MetzMetz | 0 - 3 | AuxerreAuxerre |
| 03 Sep 21 | r03 | Doxa KatokopiasDoxa Katokopi | 2 - 2 | Omonia 29is MaiouOmonia 29is M |
| 03 Sep 21 | r03 | Szombathelyi HaladásSzombathelyi | 0 - 1 | SKN St. PoltenSKN St. Polte |
| 03 Sep 21 | r03 | Levski SofiaLevski Sofia | 2 - 1 | Sportist SvogeSportist Svog |
| 03 Sep 21 | r03 | ASILASIL | 10 - 0 | Ethnikos AchnaEthnikos Achn |
| 03 Sep 21 | r03 | VasasVasas | 0 - 1 | MynaiMynai |
| 03 Sep 21 | r03 | Lokomotiv PlovdivLokomotiv Plo | 1 - 0 | CSKA 1948 IICSKA 1948 II |
| 03 Sep 21 | r03 | LecceLecce | 3 - 2 | U.S.D. Città di FasanoU.S.D. Città |
| 03 Sep 21 | r03 | AEK LarnacaAEK Larnaca | 3 - 0 | Enosis Neon ParalimniEnosis Neon P |
| 03 Sep 21 | r03 | Anorthosis FamagustaAnorthosis Fa | 5 - 1 | KarmiotissaKarmiotissa |
| 03 Sep 21 | r03 | Nea Salamis FamagustaNea Salamis F | 2 - 1 | PAEEKPAEEK |
| 03 Sep 21 | r03 | ArisAris | 1 - 1 | OlympiakosOlympiakos |
| 03 Sep 21 | r03 | Aris LimassolAris Limassol | 0 - 0 | AEL LimassolAEL Limassol |
| 03 Sep 21 | r03 | Rakow CzestochowaRakow Czestoc | 5 - 2 | Videoton FC FehervarVideoton FC F |
| 03 Sep 21 | r03 | OFIOFI | 1 - 0 | ErgotelisErgotelis |
| 03 Sep 21 | r03 | Achyronas LiopetriouAchyronas Lio | 0 - 8 | Olympiakos NicosiaOlympiakos Ni |
| 03 Sep 21 | r03 | Olympiakos NicosiaOlympiakos Ni | 0 - 8 | Achyronas LiopetriouAchyronas Lio |
| 04 Sep 21 | r03 | Lokomotiv SofiaLokomotiv Sof | 0 - 1 | CSKA 1948CSKA 1948 |
| 04 Sep 21 | r03 | CSA Steaua BucureştiCSA Steaua Bu | 1 - 2 | FC VoluntariFC Voluntari |
| 04 Sep 21 | r03 | BeroeBeroe | 1 - 3 | Arda KardzhaliArda Kardzhal |
| 04 Sep 21 | r03 | Arges PitestiArges Pitesti | 2 - 2 | Rapid BucurestiRapid Bucures |
| 04 Sep 21 | r03 | NK AluminijNK Aluminij | 2 - 0 | DomzaleDomzale |
| 04 Sep 21 | r03 | FC MinskFC Minsk | 1 - 5 | BATE BorisovBATE Borisov |
| 04 Sep 21 | r03 | SampdoriaSampdoria | 3 - 1 | TernanaTernana |
| 04 Sep 21 | r03 | Wisla PlockWisla Plock | 0 - 1 | Stomil OlsztynStomil Olszty |
| 04 Sep 21 | r03 | Korona KielceKorona Kielce | 1 - 1 | Radomiak RadomRadomiak Rado |
| 04 Sep 21 | r03 | Napredak KruševacNapredak Kruš | 0 - 2 | Mladost LučaniMladost Lučan |
| 04 Sep 21 | r03 | Zaglebie LubinZaglebie Lubi | 1 - 2 | Lech PoznanLech Poznan |
| 04 Sep 21 | r03 | Slaven Belupo KoprivnicaSlaven Belupo | 4 - 1 | CibaliaCibalia |
| 04 Sep 21 | r03 | VorsklaVorskla | 1 - 2 | FC Metalist KharkivFC Metalist K |
| 04 Sep 21 | r03 | AueAue | 6 - 0 | Hallescher FCHallescher FC |
| 04 Sep 21 | r03 | AlessandriaAlessandria | 3 - 2 | GenoaGenoa |
| 04 Sep 21 | r03 | Academica ClinceniAcademica Cli | 1 - 1 | FC U Craiova 1948FC U Craiova |
| 04 Sep 21 | r03 | ZoryaZorya | 3 - 1 | InhuletsInhulets |
| 04 Sep 21 | r03 | ArzignanoChiampoArzignanoChia | 1 - 1 | L.R. Vicenza VirtusL.R. Vicenza |
| 04 Sep 21 | r03 | U.S.D. Real Forte dei MarU.S.D. Real F | 2 - 8 | EmpoliEmpoli |
| 04 Sep 21 | r03 | NK LokomotivaNK Lokomotiva | 3 - 0 | NK MariborNK Maribor |
| 04 Sep 21 | r03 | UdineseUdinese | 4 - 1 | Dolomiti BellunesiDolomiti Bell |
| 04 Sep 21 | r03 | SC Dnipro-1SC Dnipro-1 | 1 - 1 | FC OlexandriaFC Olexandria |
| 04 Sep 21 | r03 | NFC VolosNFC Volos | 2 - 0 | Niki VolouNiki Volou |
| 04 Sep 21 | r03 | SassuoloSassuolo | 0 - 2 | CremoneseCremonese |
| 04 Sep 21 | r03 | BresciaBrescia | 4 - 0 | VeneziaVenezia |
| 04 Sep 21 | r03 | PanduriiPandurii | - | FC U Craiova 1948FC U Craiova |
| 04 Sep 21 | r03 | GKS KatowiceGKS Katowice | 0 - 2 | Banik OstravaBanik Ostrava |
| 04 Sep 21 | r03 | Uta AradUta Arad | 0 - 0 | KolubaraKolubara |
| 04 Sep 21 | r03 | PanetolikosPanetolikos | 3 - 1 | Panathinaikos IIPanathinaikos |
| 04 Sep 21 | r03 | Lamezia TermeLamezia Terme | 0 - 2 | RegginaReggina |
| 05 Sep 21 | r03 | FC Kolos KovalivkaFC Kolos Kova | 2 - 1 | DesnaDesna |
| 05 Sep 21 | r03 | Isloch Minsk RaionIsloch Minsk | 2 - 1 | FC SmorgonFC Smorgon |
| 05 Sep 21 | r03 | SPAL 2013SPAL 2013 | 6 - 2 | RiminiRimini |
| 05 Sep 21 | r03 | CSKA MoscowCSKA Moscow | 1 - 2 | Lok. MoscowLok. Moscow |
| 05 Sep 21 | r03 | CFR Cluj-NapocaCFR Cluj-Napo | 6 - 0 | Gaz Metan MediașGaz Metan Med |
| 05 Sep 21 | r03 | Ethnikos AchnaEthnikos Achn | 0 - 1 | Omonia NicosiaOmonia Nicosi |
| 05 Sep 21 | r03 | Apollon LimassolApollon Limas | 2 - 1 | OnisilosOnisilos |
| 06 Sep 21 | r03 | NapoliNapoli | 1 - 5 | BeneventoBenevento |
| 06 Sep 21 | r03 | Universitatea CraiovaUniversitatea | 2 - 0 | MetaloglobusMetaloglobus |
| 06 Sep 21 | r03 | FK Rubin KazanFK Rubin Kaza | 1 - 3 | FC KrasnodarFC Krasnodar |
| 06 Oct 21 | r03 | VirtonVirton | 4 - 2 | UT PétangeUT Pétange |
| 07 Oct 21 | r03 | LeonLeon | 1 - 0 | MazatlánMazatlán |
| 07 Oct 21 | r03 | KV OostendeKV Oostende | 5 - 2 | WaregemWaregem |
| 07 Oct 21 | r03 | AnderlechtAnderlecht | 4 - 1 | WesterloWesterlo |
| 07 Oct 21 | r03 | AIKAIK | 1 - 3 | Joenkoeping S.Joenkoeping S |
| 07 Oct 21 | r03 | Wuerzburger KickersWuerzburger K | 3 - 1 | Sonnenhof GroßaspachSonnenhof Gro |
| 07 Oct 21 | r03 | OnisilosOnisilos | 1 - 7 | Olympiakos NicosiaOlympiakos Ni |
| 07 Oct 21 | r03 | Rapid ViennaRapid Vienna | - | FC BW LinzFC BW Linz |
| 07 Oct 21 | r03 | Rapid Wien IIRapid Wien II | 3 - 2 | FC BW LinzFC BW Linz |
| 07 Oct 21 | r03 | LübeckLübeck | 0 - 2 | Schalke 04Schalke 04 |
| 08 Oct 21 | r03 | San Jose EarthquakesSan Jose Eart | 2 - 0 | Cruz AzulCruz Azul |
| 08 Oct 21 | r03 | Arda KardzhaliArda Kardzhal | 3 - 0 | Maritsa PlovdivMaritsa Plovd |
| 08 Oct 21 | r03 | RFC SeraingRFC Seraing | - | Mouscron-PeruwelzMouscron-Peru |
| 08 Oct 21 | r03 | LiberecLiberec | 0 - 0 | ChrudimChrudim |
| 08 Oct 21 | r03 | Kispest HonvedKispest Honve | 3 - 0 | SiófokSiófok |
| 08 Oct 21 | r03 | Budafoki MTEBudafoki MTE | 0 - 2 | Paksi FCPaksi FC |
| 08 Oct 21 | r03 | NurnbergNurnberg | 0 - 7 | IngolstadtIngolstadt |
| 08 Oct 21 | r03 | KMSK DeinzeKMSK Deinze | - | MechelenMechelen |
| 08 Oct 21 | r03 | Lechia GdańskLechia Gdańsk | 5 - 0 | Stomil OlsztynStomil Olszty |
| 08 Oct 21 | r03 | Tsarsko SeloTsarsko Selo | 0 - 2 | Lokomotiv PlovdivLokomotiv Plo |
| 08 Oct 21 | r03 | Dukla PrahaDukla Praha | 4 - 3 | Bohemians 1905Bohemians 190 |
| 08 Oct 21 | r03 | DomzaleDomzale | 1 - 2 | SesveteSesvete |
| 08 Oct 21 | r03 | Kisvárda FCKisvárda FC | 4 - 1 | MynaiMynai |
| 08 Oct 21 | r03 | VasasVasas | 2 - 1 | Újpest FCÚjpest FC |
| 08 Oct 21 | r03 | PAEEKPAEEK | 2 - 3 | Olympiakos NicosiaOlympiakos Ni |
| 08 Oct 21 | r03 | RijekaRijeka | 6 - 1 | Olimpija LjubljanaOlimpija Ljub |
| 09 Oct 21 | r03 | CF AmericaCF America | 0 - 1 | PumasPumas |
| 09 Oct 21 | r03 | Steaua BucurestiSteaua Bucure | - | FC VoluntariFC Voluntari |
| 09 Oct 21 | r03 | CSA Steaua BucureştiCSA Steaua Bu | 2 - 1 | FC VoluntariFC Voluntari |
| 09 Oct 21 | r03 | CSKA 1948CSKA 1948 | 2 - 0 | Marek DupnitsaMarek Dupnits |
| 09 Oct 21 | r03 | Gaz Metan MediașGaz Metan Med | 2 - 0 | SCM Gloria BuzăuSCM Gloria Bu |
| 09 Oct 21 | r03 | Dinamo BucurestiDinamo Bucure | 3 - 2 | PetrolulPetrolul |
| 09 Oct 21 | r03 | BATE BorisovBATE Borisov | 2 - 1 | Isloch Minsk RaionIsloch Minsk |
| 09 Oct 21 | r03 | Zaglebie LubinZaglebie Lubi | 1 - 1 | Chrobry GłogówChrobry Głogó |
| 09 Oct 21 | r03 | CS MioveniCS Mioveni | 1 - 0 | Rapid BucurestiRapid Bucures |
| 09 Oct 21 | r03 | DiosgyorDiosgyor | 1 - 4 | Mezőkövesdi SEMezőkövesdi S |
| 09 Oct 21 | r03 | Rakow CzestochowaRakow Czestoc | 1 - 0 | Podbeskidzie Bielsko-BialPodbeskidzie |
| 09 Oct 21 | r03 | HNK GoricaHNK Gorica | - | Slaven Belupo KoprivnicaSlaven Belupo |
| 09 Oct 21 | r03 | SC Dnipro-1SC Dnipro-1 | 2 - 2 | FC Metalist KharkivFC Metalist K |
| 09 Oct 21 | r03 | Lech PoznanLech Poznan | 5 - 1 | LKS LodzLKS Lodz |
| 09 Oct 21 | r03 | Dynamo BrestDynamo Brest | 3 - 2 | Neman GrodnoNeman Grodno |
| 09 Oct 21 | r03 | FC KrasnodarFC Krasnodar | 2 - 1 | FK Rubin KazanFK Rubin Kaza |
| 09 Oct 21 | r03 | UdineseUdinese | 2 - 1 | Tabor SežanaTabor Sežana |
| 09 Oct 21 | r03 | EmpoliEmpoli | 2 - 1 | TernanaTernana |
| 09 Oct 21 | r03 | Ludogorets RazgradLudogorets Ra | 2 - 2 | Yantra GabrovoYantra Gabrov |
| 10 Oct 21 | r03 | TolucaToluca | 0 - 2 | TigresTigres |
| 10 Oct 21 | r03 | CD GuadalajaraCD Guadalajar | - | LeonLeon |
| 10 Oct 21 | r03 | CSKA MoscowCSKA Moscow | 1 - 1 | Nizhny NovgorodNizhny Novgor |
| 10 Oct 21 | r03 | Khimki FKKhimki FK | 2 - 2 | FK Arsenal DzerzhinskFK Arsenal Dz |
| 10 Oct 21 | r03 | FC LvivFC Lviv | 2 - 0 | Veres RivneVeres Rivne |
| 11 Oct 21 | r03 | CFR Cluj-NapocaCFR Cluj-Napo | 4 - 0 | Unirea DejUnirea Dej |
| 11 Oct 21 | r03 | Ural S.RUral S.R | 1 - 1 | Krylya Sovetov SamaraKrylya Soveto |
| 12 Oct 21 | r03 | Levski SofiaLevski Sofia | 4 - 0 | Strumska SlavaStrumska Slav |
| 30 Oct 21 | r03 | Dinamo MinskDinamo Minsk | 2 - 2 | Isloch Minsk RaionIsloch Minsk |
| 10 Nov 21 | r03 | Achyronas LiopetriouAchyronas Lio | 1 - 3 | Olympiakos NicosiaOlympiakos Ni |
| 10 Nov 21 | r03 | WolfsburgWolfsburg | 1 - 3 | Hansa RostockHansa Rostock |
| 10 Nov 21 | r03 | FC KolnFC Koln | 4 - 0 | PaderbornPaderborn |
| 10 Nov 21 | r03 | StuttgartStuttgart | 1 - 0 | ZurichZurich |
| 10 Nov 21 | r03 | EsbjergEsbjerg | 2 - 1 | AGF AarhusAGF Aarhus |
| 11 Nov 21 | r03 | GentGent | 1 - 3 | KortrijkKortrijk |
| 11 Nov 21 | r03 | Oud-Heverlee LeuvenOud-Heverlee | 0 - 2 | GenkGenk |
| 11 Nov 21 | r03 | KV OostendeKV Oostende | 4 - 4 | KMSK DeinzeKMSK Deinze |
| 11 Nov 21 | r03 | KarlsruheKarlsruhe | 1 - 2 | FreiburgFreiburg |
| 11 Nov 21 | r03 | Cherno MoreCherno More | 3 - 1 | DobrudzhaDobrudzha |
| 11 Nov 21 | r03 | NurnbergNurnberg | 2 - 0 | SC Rheindorf AltachSC Rheindorf |
| 11 Nov 21 | r03 | Fortuna DüsseldorfFortuna Düsse | 2 - 1 | SC Heracles AlmeloSC Heracles A |
| 11 Nov 21 | r03 | OsnabrueckOsnabrueck | 2 - 1 | SC HeerenveenSC Heerenveen |
| 11 Nov 21 | r03 | St PauliSt Pauli | 2 - 2 | ViborgViborg |
| 11 Nov 21 | r03 | GrasshoppersGrasshoppers | 3 - 1 | VaduzVaduz |
| 11 Nov 21 | r03 | HamburgHamburg | 7 - 4 | FC NordsjællandFC Nordsjælla |
| 11 Nov 21 | r03 | SV MeppenSV Meppen | 0 - 3 | Go Ahead EaglesGo Ahead Eagl |
| 11 Nov 21 | r03 | TSV HartbergTSV Hartberg | 1 - 1 | NK BravoNK Bravo |
| 11 Nov 21 | r03 | Lask Juniors LinzLask Juniors | - | TSV HartbergTSV Hartberg |
| 11 Nov 21 | r03 | Lask Juniors LinzLask Juniors | 0 - 2 | FC BW LinzFC BW Linz |
| 11 Nov 21 | r03 | Jahn RegensburgJahn Regensbu | 3 - 1 | AueAue |
| 11 Nov 21 | r03 | Apollon LimassolApollon Limas | 4 - 1 | Omonia AradippouOmonia Aradip |
| 11 Nov 21 | r03 | SV HornSV Horn | 1 - 1 | Rapid Wien IIRapid Wien II |
| 11 Nov 21 | r03 | RasenBallsport LeipzigRasenBallspor | 2 - 1 | FC EilenburgFC Eilenburg |
| 12 Nov 21 | r03 | AalesundAalesund | - | MoldeMolde |
| 12 Nov 21 | r03 | Gornik ZabrzeGornik Zabrze | 0 - 1 | SFC OpavaSFC Opava |
| 12 Nov 21 | r03 | Videoton FC FehervarVideoton FC F | 2 - 0 | Budafoki MTEBudafoki MTE |
| 12 Nov 21 | r03 | TSC Bačka TopolaTSC Bačka Top | 0 - 0 | Szeged-CsanádSzeged-Csanád |
| 12 Nov 21 | r03 | Kispest HonvedKispest Honve | 1 - 0 | BudaörsBudaörs |
| 12 Nov 21 | r03 | PetrolulPetrolul | 1 - 4 | Chindia TârgovișteChindia Târgo |
| 12 Nov 21 | r03 | Cercle BruggeCercle Brugge | 5 - 1 | Mouscron-PeruwelzMouscron-Peru |
| 12 Nov 21 | r03 | ChrudimChrudim | 0 - 3 | Bohemians 1905Bohemians 190 |
| 12 Nov 21 | r03 | Stal MielecStal Mielec | 1 - 1 | Wisla KrakowWisla Krakow |
| 12 Nov 21 | r03 | NK LokomotivaNK Lokomotiva | 3 - 2 | DubravaDubrava |
| 12 Nov 21 | r03 | WesterloWesterlo | 4 - 0 | Beerschot VABeerschot VA |
| 12 Nov 21 | r03 | Tsarsko SeloTsarsko Selo | 2 - 2 | Sportist SvogeSportist Svog |
| 12 Nov 21 | r03 | OsijekOsijek | 2 - 0 | Szentlőrinc SESzentlőrinc S |
| 12 Nov 21 | r03 | Slaven Belupo KoprivnicaSlaven Belupo | 2 - 1 | RudešRudeš |
| 12 Nov 21 | r03 | DomzaleDomzale | 2 - 3 | OpatijaOpatija |
| 12 Nov 21 | r03 | MetzMetz | 2 - 1 | KaiserslauternKaiserslauter |
| 12 Nov 21 | r03 | St. GallenSt. Gallen | 3 - 4 | Wacker InnsbruckWacker Innsbr |
| 12 Nov 21 | r03 | OFIOFI | 0 - 2 | Olympiakos NicosiaOlympiakos Ni |
| 13 Nov 21 | r03 | FC SmorgonFC Smorgon | 2 - 0 | Isloch Minsk RaionIsloch Minsk |
| 13 Nov 21 | r03 | FC VoluntariFC Voluntari | 6 - 0 | MetaloglobusMetaloglobus |
| 13 Nov 21 | r03 | Gaz Metan MediașGaz Metan Med | 2 - 2 | FC HermannstadtFC Hermannsta |
| 13 Nov 21 | r03 | Zaglebie SosnowiecZaglebie Sosn | 1 - 1 | Tychy 71Tychy 71 |
| 13 Nov 21 | r03 | SCM Gloria BuzăuSCM Gloria Bu | 2 - 3 | Dinamo BucurestiDinamo Bucure |
| 13 Nov 21 | r03 | Rakow CzestochowaRakow Czestoc | 0 - 1 | Wisla PlockWisla Plock |
| 13 Nov 21 | r03 | Levski SofiaLevski Sofia | 0 - 1 | Pirin BlagoevgradPirin Blagoev |
| 13 Nov 21 | r03 | Tabor SežanaTabor Sežana | 2 - 1 | VeneziaVenezia |
| 13 Nov 21 | r03 | Dinamo MinskDinamo Minsk | 0 - 1 | FC SlutskFC Slutsk |
| 13 Nov 21 | r03 | BeroeBeroe | 1 - 2 | Arda KardzhaliArda Kardzhal |
| 13 Nov 21 | r03 | MynaiMynai | 2 - 2 | FC LvivFC Lviv |
| 13 Nov 21 | r03 | FC U Craiova 1948FC U Craiova | 4 - 1 | CSA Steaua BucureştiCSA Steaua Bu |
| 13 Nov 21 | r03 | HNK GoricaHNK Gorica | 3 - 3 | CeljeCelje |
| 13 Nov 21 | r03 | EmpoliEmpoli | 1 - 1 | PerugiaPerugia |
| 13 Nov 21 | r03 | UdineseUdinese | 2 - 2 | KoperKoper |
| 14 Nov 21 | r03 | Universitatea CraiovaUniversitatea | 2 - 1 | ACS SirineasaACS Sirineasa |
| 14 Nov 21 | r03 | CSKA MoscowCSKA Moscow | 3 - 1 | FC UfaFC Ufa |
| 14 Nov 21 | r03 | Khimki FKKhimki FK | 0 - 4 | Krylya Sovetov SamaraKrylya Soveto |
| 14 Nov 21 | r03 | FC YessentukiFC Yessentuki | 1 - 7 | Ural S.RUral S.R |
| 14 Nov 21 | r03 | FC OlexandriaFC Olexandria | 3 - 1 | InhuletsInhulets |
| 14 Nov 21 | r03 | CFR Cluj-NapocaCFR Cluj-Napo | 1 - 0 | Unirea DejUnirea Dej |
| 15 Nov 21 | r03 | DesnaDesna | 1 - 0 | Olimpik DonetskOlimpik Donet |
| 17 Nov 21 | r03 | Dinamo BucurestiDinamo Bucure | 2 - 1 | AstraAstra |
| 03 Dec 21 | r03 | FC CopenhagenFC Copenhagen | - | Silkeborg IFSilkeborg IF |
| 03 Dec 21 | r03 | First ViennaFirst Vienna | - | SKN St. PoltenSKN St. Polte |
| 09 Dec 21 | r03 | Austria Vienna (Am)Austria Vienn | - | SKN St. PoltenSKN St. Polte |
| 18 Dec 21 | r03 | FC HakaFC Haka | 0 - 3 | IlvesIlves |
| 18 Dec 21 | r03 | KuPS KuopioKuPS Kuopio | 3 - 0 | MPMP |
| 25 Dec 21 | r03 | Energetik-BGU MinskEnergetik-BGU | 3 - 3 | Isloch Minsk RaionIsloch Minsk |
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