| 17 Aug 20 | r05  | St.TruidenSt.Truiden | 1 - 1 | Lommel SKLommel SK |
| 17 Aug 20 | r05 | Mosta FCMosta FC | 2 - 1 | Gudja UnitedGudja United |
| 17 Aug 20 | r05 | FC EindhovenFC Eindhoven | 1 - 0 | Jong PSVJong PSV |
| 17 Aug 20 | r05 | BirkirkaraBirkirkara | - | Zejtun CorinthiansZejtun Corint |
| 18 Aug 20 | r05 | SC TelstarSC Telstar | 0 - 0 | SpartaSparta |
| 18 Aug 20 | r05 | BlackpoolBlackpool | 2 - 1 | BarrowBarrow |
| 18 Aug 20 | r05 | Fortuna DüsseldorfFortuna Düsse | - | Wehen WiesbadenWehen Wiesbad |
| 18 Aug 20 | r05 | AueAue | 4 - 0 | Pogon SzczecinPogon Szczeci |
| 18 Aug 20 | r05 | FC KolnFC Koln | 2 - 0 | BochumBochum |
| 18 Aug 20 | r05 | AjaxAjax | 2 - 0 | Wolfsberger ACWolfsberger A |
| 18 Aug 20 | r05 | Schalke 04Schalke 04 | 1 - 3 | KFC Uerdingen 05KFC Uerdingen |
| 18 Aug 20 | r05 | SC VerlSC Verl | 1 - 2 | BielefeldBielefeld |
| 18 Aug 20 | r05 | NEC NijmegenNEC Nijmegen | 4 - 0 | TOP OssTOP Oss |
| 18 Aug 20 | r05 | RKC WaalwijkRKC Waalwijk | 0 - 2 | NAC BredaNAC Breda |
| 18 Aug 20 | r05 | CurzonCurzon | 2 - 3 | OldhamOldham |
| 18 Aug 20 | r05 | Gateshead FCGateshead FC | 1 - 1 | CarlisleCarlisle |
| 18 Aug 20 | r05 | Lija AthleticLija Athletic | 0 - 1 | Senglea AthleticSenglea Athle |
| 18 Aug 20 | r05 | Enfield TownEnfield Town | 3 - 1 | ChelmsfordChelmsford |
| 18 Aug 20 | r05 | Cray Valley PMCray Valley P | 1 - 1 | Welling UnitedWelling Unite |
| 19 Aug 20 | r05 | Zaglebie SosnowiecZaglebie Sosn | 2 - 0 | Odra OpoleOdra Opole |
| 19 Aug 20 | r05 | Randers FCRanders FC | 5 - 1 | ViborgViborg |
| 19 Aug 20 | r05 | UnterhachingUnterhaching | 2 - 2 | KarlsruheKarlsruhe |
| 19 Aug 20 | r05 | Mainz IIMainz II | 0 - 4 | FC SchweinfurtFC Schweinfur |
| 19 Aug 20 | r05 | FC EmmenFC Emmen | 0 - 2 | SC Heracles AlmeloSC Heracles A |
| 19 Aug 20 | r05 | Vejle BoldklubVejle Boldklu | 0 - 1 | HOBROHOBRO |
| 19 Aug 20 | r05 | MainzMainz | - | StuttgartStuttgart |
| 19 Aug 20 | r05 | Rapid ViennaRapid Vienna | 0 - 7 | Lask Juniors LinzLask Juniors |
| 19 Aug 20 | r05 | RizesporRizespor | 0 - 3 | AlanyasporAlanyaspor |
| 19 Aug 20 | r05 | YpsonasYpsonas | 2 - 3 | AEZAEZ |
| 19 Aug 20 | r05 | Austria KlagenfurtAustria Klage | 1 - 1 | PaderbornPaderborn |
| 19 Aug 20 | r05 | LamiaLamia | 1 - 1 | PanetolikosPanetolikos |
| 19 Aug 20 | r05 | LASKLASK | 1 - 4 | Werder BremenWerder Bremen |
| 19 Aug 20 | r05 | EsbjergEsbjerg | 2 - 1 | AaBAaB |
| 19 Aug 20 | r05 | Lüneburger SK HansaLüneburger SK | 2 - 0 | Wolfsburg IIWolfsburg II |
| 19 Aug 20 | r05 | Skive IKSkive IK | 1 - 0 | ThistedThisted |
| 19 Aug 20 | r05 | FC HelsingoerFC Helsingoer | 1 - 0 | Næstved BKNæstved BK |
| 19 Aug 20 | r05 | ExcelsiorExcelsior | 2 - 1 | Helmond SportHelmond Sport |
| 19 Aug 20 | r05 | TSV HartbergTSV Hartberg | - | SV LafnitzSV Lafnitz |
| 19 Aug 20 | r05 | OldenburgOldenburg | 0 - 7 | RödinghausenRödinghausen |
| 19 Aug 20 | r05 | Atherton CollieriesAtherton Coll | 1 - 4 | RochdaleRochdale |
| 20 Aug 20 | r05 | FredericiaFredericia | 3 - 2 | SønderjyskeSønderjyske |
| 20 Aug 20 | r05 | Türkgücü MünchenTürkgücü Münc | 1 - 4 | AugsburgAugsburg |
| 20 Aug 20 | r05 | AZ AlkmaarAZ Alkmaar | - | Fortuna SittardFortuna Sitta |
| 20 Aug 20 | r05 | HamburgHamburg | 0 - 2 | FC MidtjyllandFC Midtjyllan |
| 20 Aug 20 | r05 | SV HornSV Horn | 2 - 2 | Wuerzburger KickersWuerzburger K |
| 20 Aug 20 | r05 | AtromitosAtromitos | 3 - 0 | GianninaGiannina |
| 20 Aug 20 | r05 | Almere City FCAlmere City F | 1 - 0 | FC Den BoschFC Den Bosch |
| 20 Aug 20 | r05 | IngolstadtIngolstadt | 1 - 2 | EichstättEichstätt |
| 20 Aug 20 | r05 | Gudja UnitedGudja United | - | Zejtun CorinthiansZejtun Corint |
| 20 Aug 20 | r05 | FC UtrechtFC Utrecht | 4 - 1 | SC HeerenveenSC Heerenveen |
| 21 Aug 20 | r05 | Bristol CityBristol City | 4 - 0 | CheltenhamCheltenham |
| 21 Aug 20 | r05 | HannoverHannover | 4 - 3 | KFC Uerdingen 05KFC Uerdingen |
| 21 Aug 20 | r05 | St PauliSt Pauli | 0 - 0 | AGF AarhusAGF Aarhus |
| 21 Aug 20 | r05 | Jong PSVJong PSV | - | VVV-VenloVVV-Venlo |
| 21 Aug 20 | r05 | TOP OssTOP Oss | - | MVV MaastrichtMVV Maastrich |
| 21 Aug 20 | r05 | SV HornSV Horn | 1 - 2 | Wolfsberger ACWolfsberger A |
| 21 Aug 20 | r05 | VaduzVaduz | 3 - 1 | FC WilFC Wil |
| 21 Aug 20 | r05 | Dynamo DresdenDynamo Dresde | 0 - 1 | BraunschweigBraunschweig |
| 21 Aug 20 | r05 | NorwichNorwich | 6 - 0 | Milton Keynes DonsMilton Keynes |
| 21 Aug 20 | r05 | WSG Swarovski TirolWSG Swarovski | 3 - 0 | Union BerlinUnion Berlin |
| 21 Aug 20 | r05 | Mgladbach IIMgladbach II | 1 - 3 | Rot-Weiß OberhausenRot-Weiß Ober |
| 21 Aug 20 | r05 | FC VolendamFC Volendam | 0 - 2 | FC GroningenFC Groningen |
| 21 Aug 20 | r05 | St. GallenSt. Gallen | 5 - 0 | Austria LustenauAustria Luste |
| 21 Aug 20 | r05 | VallettaValletta | - | Lija AthleticLija Athletic |
| 21 Aug 20 | r05 | Evian Thonon GaillardEvian Thonon | 0 - 8 | ServetteServette |
| 21 Aug 20 | r05 | Willem IIWillem II | 1 - 1 | PSV EindhovenPSV Eindhoven |
| 21 Aug 20 | r05 | ExeterExeter | 1 - 1 | Taunton TownTaunton Town |
| 21 Aug 20 | r05 | KaiserslauternKaiserslauter | - | Bayern AlzenauBayern Alzena |
| 21 Aug 20 | r05 | Mosta FCMosta FC | 0 - 1 | Senglea AthleticSenglea Athle |
| 22 Aug 20 | r05 | FC Politehnica TimisoaraFC Politehnic | 2 - 2 | Ripensia TimisoaraRipensia Timi |
| 22 Aug 20 | r05 | SV KapfenbergSV Kapfenberg | 1 - 0 | FC BW LinzFC BW Linz |
| 22 Aug 20 | r05 | Tychy 71Tychy 71 | 1 - 3 | Widzew LodzWidzew Lodz |
| 22 Aug 20 | r05 | ZurichZurich | 2 - 5 | SchaffhausenSchaffhausen |
| 22 Aug 20 | r05 | Rio AveRio Ave | - | PenafielPenafiel |
| 22 Aug 20 | r05 | AaBAaB | 1 - 2 | Silkeborg IFSilkeborg IF |
| 22 Aug 20 | r05 | Gornik LecznaGornik Leczna | 0 - 1 | Znicz PruszkówZnicz Pruszkó |
| 22 Aug 20 | r05 | BirminghamBirmingham | 1 - 1 | CharltonCharlton |
| 22 Aug 20 | r05 | Bonner SCBonner SC | 1 - 6 | Viktoria KölnViktoria Köln |
| 22 Aug 20 | r05 | BrøndbyBrøndby | 3 - 1 | Næstved BKNæstved BK |
| 22 Aug 20 | r05 | ChainatChainat | 5 - 1 | Samut Sakhon FCSamut Sakhon |
| 22 Aug 20 | r05 | SV HeimstettenSV Heimstette | 2 - 7 | Bayern Munich IIBayern Munich |
| 22 Aug 20 | r05 | HoffenheimHoffenheim | 2 - 5 | SPVGG Greuther FürthSPVGG Greuthe |
| 22 Aug 20 | r05 | LyngbyLyngby | 3 - 0 | Hvidovre IFHvidovre IF |
| 22 Aug 20 | r05 | SpartaSparta | 1 - 1 | NAC BredaNAC Breda |
| 22 Aug 20 | r05 | Vejle BoldklubVejle Boldklu | 3 - 4 | ViborgViborg |
| 22 Aug 20 | r05 | QPRQPR | 3 - 0 | AFC WimbledonAFC Wimbledon |
| 22 Aug 20 | r05 | AalenAalen | 6 - 0 | FC MemmingenFC Memmingen |
| 22 Aug 20 | r05 | Almere City FCAlmere City F | 1 - 1 | FC GroningenFC Groningen |
| 22 Aug 20 | r05 | Bayern AlzenauBayern Alzena | 2 - 2 | SpVgg Greuther Fürth IISpVgg Greuthe |
| 22 Aug 20 | r05 | Fleetwood TownFleetwood Tow | 1 - 4 | BlackburnBlackburn |
| 22 Aug 20 | r05 | Hallescher FCHallescher FC | 2 - 1 | Hannover IIHannover II |
| 22 Aug 20 | r05 | MainzMainz | 0 - 1 | SandhausenSandhausen |
| 22 Aug 20 | r05 | Mainz IIMainz II | 4 - 3 | Fortuna Düsseldorf IIFortuna Düsse |
| 22 Aug 20 | r05 | MansfieldMansfield | 0 - 3 | RotherhamRotherham |
| 22 Aug 20 | r05 | NEC NijmegenNEC Nijmegen | 2 - 1 | RKC WaalwijkRKC Waalwijk |
| 22 Aug 20 | r05 | NorthamptonNorthampton | 1 - 0 | Leyton OrientLeyton Orient |
| 22 Aug 20 | r05 | Zaglebie SosnowiecZaglebie Sosn | 0 - 2 | Resovia RzeszówResovia Rzesz |
| 22 Aug 20 | r05 | SC CambuurSC Cambuur | 4 - 2 | FC DordrechtFC Dordrecht |
| 22 Aug 20 | r05 | DornbirnDornbirn | 1 - 8 | FreiburgFreiburg |
| 22 Aug 20 | r05 | De GraafschapDe Graafschap | 1 - 0 | SC Heracles AlmeloSC Heracles A |
| 22 Aug 20 | r05 | ReadingReading | 2 - 1 | GillinghamGillingham |
| 22 Aug 20 | r05 | Roda JCRoda JC | 2 - 1 | Jong UtrechtJong Utrecht |
| 22 Aug 20 | r05 | Fortuna DüsseldorfFortuna Düsse | 1 - 0 | BochumBochum |
| 22 Aug 20 | r05 | Fremad AmagerFremad Amager | 2 - 1 | KøgeKøge |
| 22 Aug 20 | r05 | Sportfreunde LotteSportfreunde | 2 - 3 | Werder Bremen IIWerder Bremen |
| 22 Aug 20 | r05 | Munich 1860Munich 1860 | 4 - 1 | Jahn RegensburgJahn Regensbu |
| 22 Aug 20 | r05 | Preußen MünsterPreußen Münst | 2 - 0 | SSV JeddelohSSV Jeddeloh |
| 22 Aug 20 | r05 | Wehen WiesbadenWehen Wiesbad | 2 - 1 | DarmstadtDarmstadt |
| 22 Aug 20 | r05 | DuisburgDuisburg | 1 - 5 | DortmundDortmund |
| 22 Aug 20 | r05 | WolfsburgWolfsburg | 2 - 0 | Holstein KielHolstein Kiel |
| 22 Aug 20 | r05 | FC United of ManchesterFC United of | 2 - 2 | BarrowBarrow |
| 22 Aug 20 | r05 | ArdsArds | 0 - 1 | Crusaders Crusaders |
| 22 Aug 20 | r05 | BlackpoolBlackpool | 3 - 3 | EvertonEverton |
| 22 Aug 20 | r05 | FenerbahceFenerbahce | 2 - 2 | KaragumrukKaragumruk |
| 22 Aug 20 | r05 | Gateshead FCGateshead FC | 1 - 3 | SunderlandSunderland |
| 22 Aug 20 | r05 | HamburgHamburg | 1 - 2 | Randers FCRanders FC |
| 22 Aug 20 | r05 | TSV HartbergTSV Hartberg | 1 - 3 | Austria KlagenfurtAustria Klage |
| 22 Aug 20 | r05 | Heybridge SwiftsHeybridge Swi | 3 - 2 | Braintree TownBraintree Tow |
| 22 Aug 20 | r05 | Salford CitySalford City | 1 - 3 | PrestonPreston |
| 22 Aug 20 | r05 | SV SalzburgSV Salzburg | 1 - 4 | AjaxAjax |
| 22 Aug 20 | r05 | SouthportSouthport | - | Huddersfield TownHuddersfield |
| 22 Aug 20 | r05 | StokeStoke | 0 - 1 | BurtonBurton |
| 22 Aug 20 | r05 | TottenhamTottenham | 3 - 0 | IpswichIpswich |
| 22 Aug 20 | r05 | PAEEKPAEEK | 0 - 0 | Alki OrokliniAlki Oroklini |
| 22 Aug 20 | r05 | FC Trenkwalder AdmiraFC Trenkwalde | 2 - 1 | SKU AmstettenSKU Amstetten |
| 22 Aug 20 | r05 | Augsburg IIAugsburg II | 0 - 3 | Nurnberg IINurnberg II |
| 22 Aug 20 | r05 | Austria ViennaAustria Vienn | 6 - 0 | Lask Juniors LinzLask Juniors |
| 22 Aug 20 | r05 | FC HeidenheimFC Heidenheim | 0 - 2 | SC Rheindorf AltachSC Rheindorf |
| 22 Aug 20 | r05 | LASKLASK | 0 - 2 | KarlsruheKarlsruhe |
| 22 Aug 20 | r05 | MetzMetz | 1 - 1 | MontpellierMontpellier |
| 22 Aug 20 | r05 | PaderbornPaderborn | 0 - 2 | MönchengladbachMönchengladba |
| 22 Aug 20 | r05 | SV Josko RiedSV Josko Ried | 2 - 2 | ZwickauZwickau |
| 22 Aug 20 | r05 | Ripensia TimisoaraRipensia Timi | - | PanduriiPandurii |
| 22 Aug 20 | r05 | SKN St. PoltenSKN St. Polte | - | Floridsdorfer ACFloridsdorfer |
| 22 Aug 20 | r05 | Sturm GrazSturm Graz | 2 - 1 | SV LafnitzSV Lafnitz |
| 22 Aug 20 | r05 | Wacker InnsbruckWacker Innsbr | 0 - 3 | UnterhachingUnterhaching |
| 22 Aug 20 | r05 | Union BerlinUnion Berlin | 1 - 2 | FC KolnFC Koln |
| 22 Aug 20 | r05 | Neuchâtel XamaxNeuchâtel Xam | 1 - 2 | ServetteServette |
| 22 Aug 20 | r05 | PSV EindhovenPSV Eindhoven | 1 - 2 | Ein FrankfurtEin Frankfurt |
| 22 Aug 20 | r05 | FC TwenteFC Twente | 2 - 0 | Go Ahead EaglesGo Ahead Eagl |
| 22 Aug 20 | r05 | Viktoria KölnViktoria Köln | 1 - 1 | FC Koln IIFC Koln II |
| 22 Aug 20 | r05 | ValenciaValencia | 1 - 0 | CastellónCastellón |
| 22 Aug 20 | r05 | BetisBetis | 1 - 0 | CadizCadiz |
| 22 Aug 20 | r05 | EspanolEspanol | 1 - 1 | HuescaHuesca |
| 22 Aug 20 | r05 | ADO Den HaagADO Den Haag | 2 - 2 | VitesseVitesse |
| 23 Aug 20 | r05 | AC HorsensAC Horsens | 2 - 0 | HOBROHOBRO |
| 23 Aug 20 | r05 | FC HelsingoerFC Helsingoer | 4 - 0 | NykøbingNykøbing |
| 23 Aug 20 | r05 | B.93B.93 | 2 - 0 | RoskildeRoskilde |
| 23 Aug 20 | r05 | AEKAEK | 1 - 2 | AtromitosAtromitos |
| 23 Aug 20 | r05 | MalagaMalaga | 1 - 0 | ValladolidValladolid |
| 23 Aug 20 | r05 | VillarrealVillarreal | 3 - 1 | Cartagena FCCartagena FC |
| 24 Aug 20 | r05 | GalatasarayGalatasaray | - | EyüpsporEyüpspor |
| 24 Aug 20 | r05 | Austria LustenauAustria Luste | 2 - 4 | Werder BremenWerder Bremen |
| 24 Aug 20 | r05 | Gaziantep FKGaziantep FK | 5 - 0 | EskisehirsporEskisehirspor |
| 24 Aug 20 | r05 | FC Den BoschFC Den Bosch | 2 - 2 | Jong AZJong AZ |
| 24 Aug 20 | r05 | SC VerlSC Verl | 0 - 3 | NorwichNorwich |
| 24 Aug 20 | r05 | Schalke 04Schalke 04 | - | Wuerzburger KickersWuerzburger K |
| 24 Aug 20 | r05 | FC EmmenFC Emmen | 0 - 1 | PEC ZwollePEC Zwolle |
| 24 Aug 20 | r05 | BirkirkaraBirkirkara | P - P | Gudja UnitedGudja United |
| 25 Aug 20 | r05 | KocaelisporKocaelispor | 1 - 0 | Etimesgut BelediyesporEtimesgut Bel |
| 25 Aug 20 | r05 | SønderjyskeSønderjyske | 3 - 2 | Vendsyssel FFVendsyssel FF |
| 25 Aug 20 | r05 | PlymouthPlymouth | 0 - 1 | MiddlesbroughMiddlesbrough |
| 25 Aug 20 | r05 | CreweCrewe | 0 - 3 | NewcastleNewcastle |
| 25 Aug 20 | r05 | FC SchweinfurtFC Schweinfur | 2 - 0 | Hoffenheim IIHoffenheim II |
| 25 Aug 20 | r05 | Dundee UnitedDundee United | 0 - 1 | Sheffield UnitedSheffield Uni |
| 25 Aug 20 | r05 | StockportStockport | 1 - 0 | Salford CitySalford City |
| 25 Aug 20 | r05 | GoztepeGoztepe | 1 - 2 | AnkaragucuAnkaragucu |
| 25 Aug 20 | r05 | Sheffield UnitedSheffield Uni | - | FC Lausanne-SportFC Lausanne-S |
| 25 Aug 20 | r05 | Türkgücü MünchenTürkgücü Münc | 1 - 0 | GrasshoppersGrasshoppers |
| 25 Aug 20 | r05 | LincolnLincoln | 4 - 0 | ScunthorpeScunthorpe |
| 25 Aug 20 | r05 | Senglea AthleticSenglea Athle | 1 - 2 | Zejtun CorinthiansZejtun Corint |
| 25 Aug 20 | r05 | AveleyAveley | 2 - 1 | Welling UnitedWelling Unite |
| 25 Aug 20 | r05 | Faversham TownFaversham Tow | 1 - 1 | Canterbury UnitedCanterbury Un |
| 26 Aug 20 | r05 | Cartagena FCCartagena FC | 0 - 1 | LeganesLeganes |
| 26 Aug 20 | r05 | LugoLugo | 1 - 2 | PonferradinaPonferradina |
| 26 Aug 20 | r05 | BrentfordBrentford | 3 - 0 | DerbyDerby |
| 26 Aug 20 | r05 | BirminghamBirmingham | 0 - 2 | LeicesterLeicester |
| 26 Aug 20 | r05 | Dynamo DresdenDynamo Dresde | 0 - 2 | NorwichNorwich |
| 26 Aug 20 | r05 | TSV Steinbach HaigerTSV Steinbach | 1 - 1 | Fortuna Düsseldorf IIFortuna Düsse |
| 26 Aug 20 | r05 | Huddersfield TownHuddersfield | - | Fleetwood TownFleetwood Tow |
| 26 Aug 20 | r05 | TrikalaTrikala | 0 - 1 | AE LarissaAE Larissa |
| 26 Aug 20 | r05 | TSV HartbergTSV Hartberg | 2 - 1 | HannoverHannover |
| 26 Aug 20 | r05 | LamiaLamia | 2 - 0 | NFC VolosNFC Volos |
| 26 Aug 20 | r05 | OldenburgOldenburg | 2 - 1 | Wuppertaler SVWuppertaler S |
| 26 Aug 20 | r05 | TuS HalternTuS Haltern | 1 - 5 | Schalke 04 IISchalke 04 II |
| 26 Aug 20 | r05 | ElversbergElversberg | 5 - 1 | FK PirmasensFK Pirmasens |
| 26 Aug 20 | r05 | AlavesAlaves | 1 - 2 | HuescaHuesca |
| 26 Aug 20 | r05 | MalagaMalaga | 1 - 2 | CadizCadiz |
| 26 Aug 20 | r05 | MirandesMirandes | 0 - 2 | OsasunaOsasuna |
| 26 Aug 20 | r05 | PanathinaikosPanathinaikos | 1 - 0 | OFIOFI |
| 26 Aug 20 | r05 | MatlockMatlock | 5 - 1 | Maine RoadMaine Road |
| 27 Aug 20 | r05 | Odense BKOdense BK | 1 - 2 | AC HorsensAC Horsens |
| 27 Aug 20 | r05 | BrøndbyBrøndby | 2 - 1 | FC HelsingoerFC Helsingoer |
| 27 Aug 20 | r05 | HOBROHOBRO | 4 - 1 | Skive IKSkive IK |
| 27 Aug 20 | r05 | MönchengladbachMönchengladba | 0 - 2 | SPVGG Greuther FürthSPVGG Greuthe |
| 27 Aug 20 | r05 | HerthaHertha | P - P | PSV EindhovenPSV Eindhoven |
| 27 Aug 20 | r05 | AltayAltay | 1 - 0 | BandırmasporBandırmaspor |
| 27 Aug 20 | r05 | TuS DassendorfTuS Dassendor | 2 - 3 | Holstein Kiel IIHolstein Kiel |
| 27 Aug 20 | r05 | RKC WaalwijkRKC Waalwijk | 1 - 1 | SpartaSparta |
| 27 Aug 20 | r05 | Gudja UnitedGudja United | 4 - 0 | Lija AthleticLija Athletic |
| 27 Aug 20 | r05 | LevanteLevante | 2 - 1 | MallorcaMallorca |
| 28 Aug 20 | r05 | FC NordsjællandFC Nordsjælla | 5 - 4 | KøgeKøge |
| 28 Aug 20 | r05 | Rio AveRio Ave | - | SociedadSociedad |
| 28 Aug 20 | r05 | FredericiaFredericia | P - P | FC MidtjyllandFC Midtjyllan |
| 28 Aug 20 | r05 | ArisAris | 0 - 1 | Schalke 04Schalke 04 |
| 28 Aug 20 | r05 | ZurichZurich | 1 - 0 | FC WilFC Wil |
| 28 Aug 20 | r05 | SV MeppenSV Meppen | 0 - 0 | SønderjyskeSønderjyske |
| 28 Aug 20 | r05 | KaiserslauternKaiserslauter | 1 - 1 | FC HomburgFC Homburg |
| 28 Aug 20 | r05 | DortmundDortmund | 1 - 1 | PaderbornPaderborn |
| 28 Aug 20 | r05 | FenerbahceFenerbahce | 1 - 1 | AlanyasporAlanyaspor |
| 28 Aug 20 | r05 | FeyenoordFeyenoord | 0 - 1 | HamburgHamburg |
| 28 Aug 20 | r05 | GalatasarayGalatasaray | 1 - 0 | IstanbulsporIstanbulspor |
| 28 Aug 20 | r05 | NewcastleNewcastle | - | FreiburgFreiburg |
| 28 Aug 20 | r05  | TottenhamTottenham | 4 - 1 | ReadingReading |
| 28 Aug 20 | r05 | VitesseVitesse | 2 - 2 | Fortuna DüsseldorfFortuna Düsse |
| 28 Aug 20 | r05 | BirkirkaraBirkirkara | - | Senglea AthleticSenglea Athle |
| 28 Aug 20 | r05 | GranadaGranada | 0 - 3 | ValladolidValladolid |
| 28 Aug 20 | r05 | ValenciaValencia | 2 - 1 | VillarrealVillarreal |
| 28 Aug 20 | r05 | Mosta FCMosta FC | 2 - 2 | Zejtun CorinthiansZejtun Corint |
| 28 Aug 20 | r05 | Warrington TownWarrington To | 3 - 2 | City of LiverpoolCity of Liver |
| 29 Aug 20 | r05 | LuganoLugano | 5 - 1 | ChiassoChiasso |
| 29 Aug 20 | r05 | OsasunaOsasuna | 2 - 1 | AlavesAlaves |
| 29 Aug 20 | r05 | SisaketSisaket | 2 - 2 | Nakhon Ratchasima FCNakhon Ratcha |
| 29 Aug 20 | r05 | Rio AveRio Ave | - | BoavistaBoavista |
| 29 Aug 20 | r05 | LeicesterLeicester | 0 - 0 | Sheffield WedsSheffield Wed |
| 29 Aug 20 | r05 | AaBAaB | 4 - 3 | Randers FCRanders FC |
| 29 Aug 20 | r05 | LyngbyLyngby | 5 - 1 | Fremad AmagerFremad Amager |
| 29 Aug 20 | r05 | Sportfreunde LotteSportfreunde | - | TSV HavelseTSV Havelse |
| 29 Aug 20 | r05 | MagdeburgMagdeburg | 1 - 1 | RödinghausenRödinghausen |
| 29 Aug 20 | r05 | PlymouthPlymouth | 2 - 1 | Forest Green RoversForest Green |
| 29 Aug 20 | r05 | BarnsleyBarnsley | 1 - 2 | NewcastleNewcastle |
| 29 Aug 20 | r05 | Viktoria KölnViktoria Köln | 0 - 0 | Dortmund IIDortmund II |
| 29 Aug 20 | r05 | EichstättEichstätt | 0 - 4 | AalenAalen |
| 29 Aug 20 | r05 | NorthamptonNorthampton | 0 - 3 | LutonLuton |
| 29 Aug 20 | r05 | FreiburgFreiburg | 3 - 1 | St. GallenSt. Gallen |
| 29 Aug 20 | r05 | StuttgartStuttgart | 2 - 0 | BielefeldBielefeld |
| 29 Aug 20 | r05 | Werder BremenWerder Bremen | 4 - 0 | FC GroningenFC Groningen |
| 29 Aug 20 | r05 | Oxford UtdOxford Utd | 1 - 0 | QPRQPR |
| 29 Aug 20 | r05 | Rot-Weiß OberhausenRot-Weiß Ober | - | Fortuna KölnFortuna Köln |
| 29 Aug 20 | r05 | Crystal PalaceCrystal Palac | 3 - 0 | CharltonCharlton |
| 29 Aug 20 | r05 | HoffenheimHoffenheim | 2 - 1 | MainzMainz |
| 29 Aug 20 | r05 | SouthportSouthport | 0 - 2 | BarrowBarrow |
| 29 Aug 20 | r05 | TottenhamTottenham | 1 - 0 | BirminghamBirmingham |
| 29 Aug 20 | r05 | WalsallWalsall | 1 - 1 | BurtonBurton |
| 29 Aug 20 | r05 | VVV-VenloVVV-Venlo | 0 - 1 | StraelenStraelen |
| 29 Aug 20 | r05 | Swindon SupermarineSwindon Super | 1 - 2 | Chippenham Town FCChippenham To |
| 29 Aug 20 | r05 | WealdstoneWealdstone | 1 - 2 | ColchesterColchester |
| 29 Aug 20 | r05 | OldhamOldham | - | BlackpoolBlackpool |
| 29 Aug 20 | r05 | LazioLazio | 2 - 2 | TriestinaTriestina |
| 29 Aug 20 | r05 | NurnbergNurnberg | 2 - 1 | Türkgücü MünchenTürkgücü Münc |
| 29 Aug 20 | r05 | ClitheroeClitheroe | 0 - 3 | FC United of ManchesterFC United of |
| 29 Aug 20 | r05 | CoventryCoventry | 3 - 2 | PeterboroPeterboro |
| 29 Aug 20 | r05 | ASILASIL | 2 - 3 | Alki OrokliniAlki Oroklini |
| 29 Aug 20 | r05 | ADO Den HaagADO Den Haag | 1 - 0 | AZ AlkmaarAZ Alkmaar |
| 29 Aug 20 | r05 | SamsunsporSamsunspor | 2 - 1 | TrabzonsporTrabzonspor |
| 29 Aug 20 | r05 | HerthaHertha | 0 - 4 | PSV EindhovenPSV Eindhoven |
| 29 Aug 20 | r05 | FC AarauFC Aarau | 5 - 1 | SC KriensSC Kriens |
| 29 Aug 20 | r05 | Real OviedoReal Oviedo | 0 - 0 | MirandesMirandes |
| 29 Aug 20 | r05 | SC Heracles AlmeloSC Heracles A | 1 - 1 | DuisburgDuisburg |
| 29 Aug 20 | r05 | SociedadSociedad | 2 - 2 | HuescaHuesca |
| 29 Aug 20 | r05 | TorinoTorino | 4 - 1 | NovaraNovara |
| 29 Aug 20 | r05 | GrasshoppersGrasshoppers | 1 - 1 | Lucerne Lucerne |
| 29 Aug 20 | r05 | Sheffield UnitedSheffield Uni | - | FC SionFC Sion |
| 29 Aug 20 | r05 | FC SionFC Sion | 3 - 1 | ThunThun |
| 29 Aug 20 | r05 | AjaxAjax | 2 - 1 | Ein FrankfurtEin Frankfurt |
| 29 Aug 20 | r05 | LevanteLevante | 0 - 0 | ValenciaValencia |
| 29 Aug 20 | r05 | MallorcaMallorca | 2 - 0 | TenerifeTenerife |
| 30 Aug 20 | r05 | AC HorsensAC Horsens | 3 - 3 | Kolding IFKolding IF |
| 30 Aug 20 | r05 | AjaxAjax | 2 - 2 | Union BerlinUnion Berlin |
| 30 Aug 20 | r05 | FC CopenhagenFC Copenhagen | 1 - 3 | Silkeborg IFSilkeborg IF |
| 30 Aug 20 | r05 | SC VerlSC Verl | 2 - 2 | FC Koln IIFC Koln II |
| 30 Aug 20 | r05 | Munich 1860Munich 1860 | 1 - 1 | Lask Juniors LinzLask Juniors |
| 30 Aug 20 | r05 | SabadellSabadell | P - P | HuescaHuesca |
| 30 Aug 20 | r05 | MalagaMalaga | 0 - 0 | GranadaGranada |
| 30 Aug 20 | r05 | Cartagena FCCartagena FC | 0 - 2 | TenerifeTenerife |
| 31 Aug 20 | r05 | GalatasarayGalatasaray | 2 - 0 | ÜmraniyesporÜmraniyespor |
| 31 Aug 20 | r05 | BlanskoBlansko | - | Zbrojovka BrnoZbrojovka Brn |
| 31 Aug 20 | r05 | FenerbahceFenerbahce | 4 - 0 | AntalyasporAntalyaspor |
| 01 Sep 20 | r05 | MiddlesbroughMiddlesbrough | 5 - 1 | NewcastleNewcastle |
| 01 Sep 20 | r05 | Wehen WiesbadenWehen Wiesbad | 1 - 0 | KaiserslauternKaiserslauter |
| 01 Sep 20 | r05 | MillwallMillwall | 0 - 1 | Crystal PalaceCrystal Palac |
| 01 Sep 20 | r05 | BirminghamBirmingham | 3 - 0 | WalsallWalsall |
| 01 Sep 20 | r05 | DerbyDerby | 0 - 2 | Sheffield UnitedSheffield Uni |
| 01 Sep 20 | r05 | EvertonEverton | - | BlackburnBlackburn |
| 01 Sep 20 | r05 | RotherhamRotherham | - | BurtonBurton |
| 01 Sep 20 | r05 | St Ives TownSt Ives Town | 2 - 6 | Soham Town RangersSoham Town Ra |
| 02 Sep 20 | r05 | F.C. Paços de FerreiraF.C. Paços de | 1 - 2 | Rio AveRio Ave |
| 02 Sep 20 | r05 | Schalke 04Schalke 04 | - | Viktoria KölnViktoria Köln |
| 02 Sep 20 | r05 | Makedonija GjPMakedonija Gj | 0 - 0 | RabotnichkiRabotnichki |
| 02 Sep 20 | r05  | BetisBetis | P - P | LASKLASK |
| 02 Sep 20 | r05 | CadizCadiz | - | AlcorconAlcorcon |
| 02 Sep 20 | r05 | VillarrealVillarreal | 2 - 0 | SociedadSociedad |
| 02 Sep 20 | r05 | MalagaMalaga | P - P | EspanolEspanol |
| 03 Sep 20 | r05 | GalatasarayGalatasaray | - | Gaziantep FKGaziantep FK |
| 04 Sep 20 | r05 | FC GroningenFC Groningen | 3 - 3 | NEC NijmegenNEC Nijmegen |
| 04 Sep 20 | r05 | CadizCadiz | - | GranadaGranada |
| 04 Sep 20 | r05 | Taunton TownTaunton Town | 3 - 1 | Chippenham Town FCChippenham To |
| 04 Sep 20 | r05 | Mosta FCMosta FC | - | BirkirkaraBirkirkara |
| 05 Sep 20 | r05 | AlmeriaAlmeria | 0 - 4 | EspanolEspanol |
| 05 Sep 20 | r05 | ViborgViborg | 0 - 2 | Skive IKSkive IK |
| 05 Sep 20 | r05 | AshtonAshton | - | Farsley CelticFarsley Celti |
| 05 Sep 20 | r05 | Gosport BoroughGosport Borou | - | Hungerford TownHungerford To |
| 05 Sep 20 | r05 | FC United of ManchesterFC United of | 1 - 1 | City of LiverpoolCity of Liver |
| 05 Sep 20 | r05 | MarineMarine | 0 - 4 | Chester CityChester City |
| 05 Sep 20 | r05 | PanathinaikosPanathinaikos | 0 - 1 | PAOKPAOK |
| 06 Sep 20 | r05 | Fremad AmagerFremad Amager | P - P | Hvidovre IFHvidovre IF |
| 07 Sep 20 | r05 | FredericiaFredericia | 1 - 3 | AC HorsensAC Horsens |
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