| 12 Oct 18 | r00  | LeinsterLeinster | 52 - 3 | WaspsWasps |
| 13 Oct 18 | r00 | Bath RugbyBath Rugby | 20 - 22 | Stade ToulousainStade Toulous |
| 13 Oct 18 | r00 | Exeter ChiefsExeter Chiefs | 10 - 10 | MunsterMunster |
| 13 Oct 18 | r00 | Montpellier Hérault RugbyMontpellier H | 21 - 15 | EdinburghEdinburgh |
| 13 Oct 18 | r00 | ScarletsScarlets | 13 - 14 | Racing Métro 92Racing Métro |
| 13 Oct 18 | r00 | UlsterUlster | 24 - 10 | Leicester TigersLeicester Tig |
| 14 Oct 18 | r00 | GloucesterGloucester | 19 - 14 | Castres OlympiqueCastres Olymp |
| 14 Oct 18 | r00 | Lyon OULyon OU | 21 - 30 | Cardiff BluesCardiff Blues |
| 14 Oct 18 | r00 | GlasgowGlasgow | 3 - 13 | SaracensSaracens |
| 14 Oct 18 | r00 | RC ToulonnaisRC Toulonnais | 25 - 26 | Newcastle FalconsNewcastle Fal |
| 19 Oct 18 | r00 | Leicester TigersLeicester Tig | 45 - 27 | ScarletsScarlets |
| 20 Oct 18 | r00 | Castres OlympiqueCastres Olymp | 29 - 25 | Exeter ChiefsExeter Chiefs |
| 20 Oct 18 | r00 | MunsterMunster | 36 - 22 | GloucesterGloucester |
| 20 Oct 18 | r00 | EdinburghEdinburgh | 40 - 14 | RC ToulonnaisRC Toulonnais |
| 20 Oct 18 | r00 | WaspsWasps | 35 - 35 | Bath RugbyBath Rugby |
| 20 Oct 18 | r00 | Racing Métro 92Racing Métro | 44 - 12 | UlsterUlster |
| 20 Oct 18 | r00 | SaracensSaracens | 29 - 10 | Lyon OULyon OU |
| 21 Oct 18 | r00 | Newcastle FalconsNewcastle Fal | 23 - 20 | Montpellier Hérault RugbyMontpellier H |
| 21 Oct 18 | r00 | Cardiff BluesCardiff Blues | 12 - 29 | GlasgowGlasgow |
| 21 Oct 18 | r00 | Stade ToulousainStade Toulous | 28 - 27 | LeinsterLeinster |
| 07 Dec 18 | r00 | EdinburghEdinburgh | 31 - 13 | Newcastle FalconsNewcastle Fal |
| 07 Dec 18 | r00 | ScarletsScarlets | 24 - 25 | UlsterUlster |
| 08 Dec 18 | r00 | Exeter ChiefsExeter Chiefs | 19 - 27 | GloucesterGloucester |
| 08 Dec 18 | r00 | Lyon OULyon OU | 22 - 42 | GlasgowGlasgow |
| 08 Dec 18 | r00 | Bath RugbyBath Rugby | 10 - 17 | LeinsterLeinster |
| 08 Dec 18 | r00 | RC ToulonnaisRC Toulonnais | 38 - 28 | Montpellier Hérault RugbyMontpellier H |
| 08 Dec 18 | r00 | WaspsWasps | 16 - 24 | Stade ToulousainStade Toulous |
| 09 Dec 18 | r00 | MunsterMunster | 30 - 5 | Castres OlympiqueCastres Olymp |
| 09 Dec 18 | r00 | SaracensSaracens | 51 - 25 | Cardiff BluesCardiff Blues |
| 09 Dec 18 | r00 | Racing Métro 92Racing Métro | 36 - 26 | Leicester TigersLeicester Tig |
| 14 Dec 18 | r00 | GloucesterGloucester | 17 - 29 | Exeter ChiefsExeter Chiefs |
| 14 Dec 18 | r00 | UlsterUlster | 30 - 15 | ScarletsScarlets |
| 15 Dec 18 | r00 | Cardiff BluesCardiff Blues | 14 - 26 | SaracensSaracens |
| 15 Dec 18 | r00 | GlasgowGlasgow | 21 - 10 | Lyon OULyon OU |
| 15 Dec 18 | r00 | Stade ToulousainStade Toulous | 42 - 27 | WaspsWasps |
| 15 Dec 18 | r00 | Castres OlympiqueCastres Olymp | 13 - 12 | MunsterMunster |
| 15 Dec 18 | r00 | LeinsterLeinster | 42 - 15 | Bath RugbyBath Rugby |
| 16 Dec 18 | r00 | Leicester TigersLeicester Tig | 11 - 34 | Racing Métro 92Racing Métro |
| 16 Dec 18 | r00 | Montpellier Hérault RugbyMontpellier H | 34 - 13 | RC ToulonnaisRC Toulonnais |
| 16 Dec 18 | r00 | Newcastle FalconsNewcastle Fal | 8 - 21 | EdinburghEdinburgh |
| 11 Jan 19 | r00 | GloucesterGloucester | 15 - 41 | MunsterMunster |
| 12 Jan 19 | r00  | LeinsterLeinster | 29 - 13 | Stade ToulousainStade Toulous |
| 12 Jan 19 | r00 | Montpellier Hérault RugbyMontpellier H | 45 - 8 | Newcastle FalconsNewcastle Fal |
| 12 Jan 19 | r00 | Bath RugbyBath Rugby | 18 - 16 | WaspsWasps |
| 12 Jan 19 | r00 | UlsterUlster | 26 - 22 | Racing Métro 92Racing Métro |
| 12 Jan 19 | r00 | RC ToulonnaisRC Toulonnais | 17 - 28 | EdinburghEdinburgh |
| 12 Jan 19 | r00 | ScarletsScarlets | 33 - 10 | Leicester TigersLeicester Tig |
| 13 Jan 19 | r00 | Exeter ChiefsExeter Chiefs | 34 - 12 | Castres OlympiqueCastres Olymp |
| 13 Jan 19 | r00 | GlasgowGlasgow | 33 - 24 | Cardiff BluesCardiff Blues |
| 13 Jan 19 | r00 | Lyon OULyon OU | 10 - 28 | SaracensSaracens |
| 18 Jan 19 | r00 | EdinburghEdinburgh | 19 - 10 | Montpellier Hérault RugbyMontpellier H |
| 18 Jan 19 | r00 | Newcastle FalconsNewcastle Fal | 24 - 27 | RC ToulonnaisRC Toulonnais |
| 19 Jan 19 | r00 | Cardiff BluesCardiff Blues | 33 - 14 | Lyon OULyon OU |
| 19 Jan 19 | r00 | SaracensSaracens | 38 - 19 | GlasgowGlasgow |
| 19 Jan 19 | r00 | Leicester TigersLeicester Tig | 13 - 14 | UlsterUlster |
| 19 Jan 19 | r00 | Racing Métro 92Racing Métro | 46 - 33 | ScarletsScarlets |
| 19 Jan 19 | r00 | Castres OlympiqueCastres Olymp | 24 - 22 | GloucesterGloucester |
| 19 Jan 19 | r00 | MunsterMunster | 9 - 7 | Exeter ChiefsExeter Chiefs |
| 20 Jan 19 | r00 | Stade ToulousainStade Toulous | 20 - 17 | Bath RugbyBath Rugby |
| 20 Jan 19 | r00 | WaspsWasps | 19 - 37 | LeinsterLeinster |
| 30 Mar 19 | r00 | EdinburghEdinburgh | 13 - 17 | MunsterMunster |
| 30 Mar 19 | r00 | SaracensSaracens | 56 - 27 | GlasgowGlasgow |
| 30 Mar 19 | r00 | LeinsterLeinster | 21 - 18 | UlsterUlster |
| 31 Mar 19 | r00 | Racing Métro 92Racing Métro | 21 - 22 | Stade ToulousainStade Toulous |
| 20 Apr 19 | r00 | SaracensSaracens | 32 - 16 | MunsterMunster |
| 21 Apr 19 | r00 | LeinsterLeinster | 30 - 12 | Stade ToulousainStade Toulous |
| 11 May 19 | r00 | LeinsterLeinster | 10 - 20 | SaracensSaracens |
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